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activation mediated microrna

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https://www.readbyqxmd.com/read/29467762/inositol-requiring-enzyme-1-mediated-downregulation-of-microrna-mir-146a-and-mir-155-in-primary-dermal-fibroblasts-across-three-tnfrsf1a-mutations-results-in-hyperresponsiveness-to-lipopolysaccharide
#1
Stephanie R Harrison, Thomas Scambler, Lylia Oubussad, Chi Wong, Miriam Wittmann, Michael F McDermott, Sinisa Savic
Tumor necrosis factor (TNF)-receptor-associated periodic fever syndrome (TRAPS) is a rare monogenic autoinflammatory disorder characterized by mutations in the TNFRSF1A gene, causing TNF-receptor 1 (TNFR1) misfolding, increased cellular stress, activation of the unfolded protein response (UPR), and hyperresponsiveness to lipopolysaccharide (LPS). Both microRNA (miR)-146a and miR-155 provide negative feedback for LPS-toll-like receptor 2/4 signaling and cytokine production, through regulation of nuclear factor kappa B (NF-κB)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29467760/microrna-regulation-of-host-immune-responses-following-fungal-exposure
#2
REVIEW
Tara L Croston, Angela R Lemons, Donald H Beezhold, Brett J Green
Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miRNAs) following fungal exposure and is overlooked, yet important, group of regulators capable of influencing fungal immune responses through a variety of cellular mechanisms. These small non-coding ribose nucleic acids function to regulate gene expression at the post-transcriptional level and have been shown to participate in multiple disease pathways including cancer, heart disease, apoptosis, as well as immune responses to microbial hazards and occupational allergens...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29467540/identification-of-a-novel-microrna-mrna-regulatory-biomodule-in-human-prostate-cancer
#3
Yanqiong Zhang, Funeng Jiang, Huichan He, Jianheng Ye, Xia Mao, Qiuyan Guo, Shu-Lin Wu, Weide Zhong, Chin-Lee Wu, Na Lin
Our recent study identified a list of differentially expressed microRNAs (miRNAs) in human prostate cancer (PCa) tissues compared to adjacent benign prostate tissues. In the current study, to identify the crucial miRNA-mRNA regulatory biomodule involved into prostate carcinogenesis based on the previous miRNA expression profile in PCa, we proposed an integrated systematic approach which combined miRNA-mediated gene expression regulatory network analysis, experimental validations in vitro and in vivo, as well as clinical significance evaluation...
February 21, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29464864/inferences-of-individual-drug-responses-across-diverse-cancer-types-using-a-novel-competing-endogenous-rna-network
#4
Yan Zhang, Xin Li, Dianshuang Zhou, Hui Zhi, Peng Wang, Yue Gao, Maoni Guo, Ming Yue, Yanxia Wang, Weitao Shen, Shangwei Ning, Yixue Li, Xia Li
Differences in individual drug responses is an obstacle to progression in cancer treatment, and predicting responses would help to plan treatment. The accumulation of cancer molecular profiling and drug response data provides opportunities and challenges to identify novel molecular signatures and mechanisms of tumor responsiveness to drugs. This study evaluated drug responses with a competing endogenous RNA (ceRNA) system that depended on competition between diverse RNA species. We identified drug response-related ceRNAs (DRCEs) by combining the sequence and expression data of long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and messenger RNAs (mRNAs) and the survival data of cancer patients treated with drugs...
February 21, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29462611/mir-29-family-members-interact-with-sparc-to-regulate-glucose-metabolism
#5
Haiyan Song, Lei Ding, Shuang Zhang, Wei Wang
MicroRNA (miR)-29 family members have been reported to play important regulatory roles in metabolic disease. We used TargetScan to show that "secreted protein acidic rich in cysteine" (SPARC) is a target of the miR-29s. SPARC is a multifunctional secretory protein involved in a variety of biological activities, and SPARC dysregulation is associated with a wide range of obesity-related disorders, including type 2 diabetes mellitus (T2DM). We explored whether miR-29s played roles in glucose metabolism and whether miR-29s directly targeted SPARC...
February 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29461595/mir-1271-negatively-regulates-akt-mtor-signaling-and-promotes-apoptosis-via-targeting-pdk1-in-pancreatic-cancer
#6
F Xie, Q Huang, C-H Liu, X-S Lin, Z Liu, L-L Liu, D-W Huang, H-C Zhou
OBJECTIVE: Pancreatic cancer (PC) possesses a very poor prognosis, and its pathogenesis is not fully understood. Evidence has suggested that microRNAs play important roles in cancer development and progression, the present study was designed to study the function of miR-1271 in PC. PATIENTS AND METHODS: PC tissues and adjacent normal tissues were collected from 17 patients. MiR-1271 and PDK1 expression were quantified by quantitative reverse-transcriptional polymerase chain reaction (RT-PCR)...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29457293/ginsenoside-rh2-inhibits-prostate-cancer-cell-growth-through-suppression-of-microrna-4295-that-activates-cdkn1a
#7
Qiruo Gao, Junhua Zheng
OBJECTIVES: Ginsenoside Rh2 (GRh2) has demonstrative therapeutic effects on a variety of diseases, including some tumours. However, the effects of GRh2 on prostate cancer (PC) cell growth remain unknown, and were, thus, addressed in the present study. MATERIALS AND METHODS: PC3 and DU145 PC cell lines were exposed to GRh2. Cell proliferation was assessed in an MTT assay and by BrdU incorporation. Apoptosis of the cells were assessed by TUNEL staining. Total RNA was assessed by RT-qPCR...
February 19, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/29456679/mir-98-inhibits-cell-proliferation-and-induces-cell-apoptosis-by-targeting-mapk6-in-huvecs
#8
Chuanxian Hu, Su Huang, Fafu Wu, Hui Ding
The aim of current study was to explore the role of microRNA (miR)-98 in atherosclerosis. Human vascular endothelial cells (HVECs) were isolated from the peripheral blood of healthy volunteers and patients with atherosclerosis. Compared with endothelial cells from the healthy control group, the expression level of mitogen activated protein kinase (MAPK)6 was significantly upregulated and miR-98 was downregulated in the endothelial cells of patients with atherosclerosis. The human umbilical vein endothelial cell line (HUVEC) was adopted to perform in vitro studies...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455573/a-creb-mediated-increase-in-mirna-let-7f-during-prolonged-%C3%AE-agonist-exposure-a-novel-mechanism-of-%C3%AE-2-adrenergic-receptor-down-regulation-in-airway-smooth-muscle
#9
Donghwa Kim, Soomin Cho, Jung A Woo, Stephen B Liggett
β2 -Adrenergic receptors (β2 ARs) desensitize during continuous agonist activation, which manifests clinically as tachyphylaxis. β-Agonist desensitization of β2 ARs in human airway smooth muscle (HASM) cells is recognized in the treatment of asthma and may be related to poor outcomes. Rapid events in desensitization include receptor phosphorylation and internalization, but mechanisms responsible for the decrease in receptor protein after prolonged agonist exposure (down-regulation) are ill defined. The microRNA (miRNA) let-7f regulates β2 AR expression by translational repression...
February 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29455449/role-of-exosomes-derived-from-mir-133b-modified-mscs-in-an-experimental-rat-model-of-intracerebral-hemorrhage
#10
Haitao Shen, Xiyang Yao, Haiying Li, Xiang Li, Tiejun Zhang, Qing Sun, Chengyuan Ji, Gang Chen
Intracerebral hemorrhage (ICH) has poor outcomes due to high mortality and morbidity, but until now, the effective treatments remain limited. MicroRNAs (miRNAs) are vital regulators of gene expression and demonstrated to be linked to the pathogenesis of various central nervous system (CNS) diseases. Exosomes are considered as cell-to-cell communication vectors and secreted largely by mesenchymal stromal cells (MSCs). The present study investigated the role of miR-133b delivered by exosomes secreted from MSCs to brain tissues in rats after ICH...
February 17, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29454608/mirna-185-serves-as-a-prognostic-factor-and-suppresses-migration-and-invasion-through-wnt1-in-colon-cancer
#11
Wenjun Zhang, Zheng Sun, Liang Su, Feng Wang, Yiming Jiang, Dengfeng Yu, Fujie Zhang, Zhe Sun, Wenbo Liang
Colon cancer is one of the deadliest cancers worldwide; abnormal microRNA expression is common during colon cancer development. The aim of the present study was to elucidate the role played by miR-185 in this context. We used quantitative real-time PCR (qRT-PCR) to measure miR-185 expression levels in colon cancer cell lines. The effects of miR-185 on colon cancer cell proliferation and invasion were assessed using the MTT, colony-forming, wound-healing, and transwell assays. A luciferase activity assay was used to confirm the target of miR-185...
February 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29453987/the-role-of-foxq1-in-proliferation-of-human-dental-pulp-stem-cell
#12
Shaoqin Tu, Junming Zheng, Xin Gao, Chenyu Guan, Bin Cai, Lusai Xiang
This study aimed to investigate the role for Foxq1 in proliferation activity regulation of dental pulp stem cells (DPSCs). Proliferation of DPSC was induced by calcium hydroxide, then expression alteration of Foxq1 was evaluated. Lentivirus was employed to manipulate Foxq1 level in DPSC, and proliferation activities were evaluated. To look into mechanism regulating Foxq1 level after calcium hydroxide stimulation, expressions of various microRNAs were evaluated, then bioinformatics study and dual-luciferase study were carried out to confirm targeting relationship between microRNA and Foxq1...
February 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29452903/extracellular-vesicles-as-key-mediators-of-plant-microbe-interactions
#13
REVIEW
Brian D Rutter, Roger W Innes
Extracellular vesicles (EVs) are lipid compartments capable of trafficking proteins, lipids, RNA and metabolites between cells. Plant cells have been shown to secrete EVs during immune responses, but virtually nothing is known about their formation, contents or ultimate function. Recently developed methods for isolating plant EVs have revealed that these EVs are enriched in stress response proteins and signaling lipids, and appear to display antifungal activity. Comparison to work on animal EVs, and the observation that host-derived small interfering RNAs and microRNAs can silence fungal genes, suggests that plant EVs may also mediate trans-kingdom RNA interference...
February 13, 2018: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29451908/cas9-mediated-excision-of-proximal-dnasei-h3k4me3-signatures-confers-robust-silencing-of-microrna-and-long-non-coding-rna-genes
#14
Harshavardhan Janga, Marina Aznaourova, Fabian Boldt, Katrin Damm, Arnold Grünweller, Leon N Schulte
CRISPR/Cas9-based approaches have greatly facilitated targeted genomic deletions. Contrary to coding genes however, which can be functionally knocked out by frame-shift mutagenesis, non-coding RNA (ncRNA) gene knockouts have remained challenging. Here we present a universal ncRNA knockout approach guided by epigenetic hallmarks, which enables robust gene silencing even in provisionally annotated gene loci. We build on previous work reporting the presence of overlapping histone H3 lysine 4 tri-methylation (H3K4me3) and DNaseI hypersensitivity sites around the transcriptional start sites of most genes...
2018: PloS One
https://www.readbyqxmd.com/read/29449535/norisoboldine-a-natural-ahr-agonist-promotes-treg-differentiation-and-attenuates-colitis-via-targeting-glycolysis-and-subsequent-nad-sirt1-suv39h1-h3k9me3-signaling-pathway
#15
Qi Lv, Kai Wang, Simiao Qiao, Ling Yang, Yirong Xin, Yue Dai, Zhifeng Wei
Norisoboldine (NOR), a natural aryl hydrocarbon receptor (AhR) agonist, has been demonstrated to attenuate ulcerative colitis (UC) and induce the generation of Treg cells. Under UC condition, hypoxia widely exists in colonic mucosa, and secondary changes of microRNAs (miRs) expressions and glycolysis contribute to Treg differentiation. At present, we worked for exploring the deep mechanisms for NOR-promoted Treg differentiation in hypoxia and its subsequent anti-UC action from the angle of AhR/miR or AhR/glycolysis axis...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29444745/microrna-598-inhibits-cell-proliferation-and-invasion-of-glioblastoma-by-directly-targeting-metastasis-associated-in-colon-cancer-1
#16
Ning Wang, Yang Zhang, Huaxin Liang
The dysregulation of microRNAs (miRNAs) expression is closely related with tumorigenesis and tumour development in glioblastoma (GBM). In this study, we found that miRNA-598 (miR-598) expression was significantly downregulated in GBM tissues and cell lines. Restoring miR-598 expression inhibited cell proliferation and invasion in GBM. Moreover, we validated that metastasis associated in colon cancer-1 (MACC1) is a novel target of miR-598 in GBM. Recovered MACC1 expression reversed the inhibitory effects of miR-598 overexpression on GBM cells...
February 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29444515/comprehensive-mirna-analysis-of-human-umbilical-cord-derived-mesenchymal-stromal-cells-and-extracellular-vesicles
#17
Xiang-Yu Zou, Yongjiang Yu, Sihao Lin, Liang Zhong, Jie Sun, Guangyuan Zhang, Yingjian Zhu
BACKGROUND/AIMS: Mesenchymal stromal cells (MSCs) participate in the tissue-specific repair of many different organs, especially the kidney. Their effects are primarily mediated by the paracrine release of factors including extracellular vesicles (EVs), which are composed of micro-vesicles and exosomes. The corresponding microRNAs (miRNAs) of EVs are considered important for their biological functions. METHODS: MSCs were cultured from the human umbilical cord, and EVs were isolated from the medium...
February 8, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29444433/microrna-223-suppresses-the-canonical-nf-%C3%AE%C2%BAb-pathway-in-basal-keratinocytes-to-dampen-neutrophilic-inflammation
#18
Wenqing Zhou, Arpita S Pal, Alan Yi-Hui Hsu, Theodore Gurol, Xiaoguang Zhu, Sara E Wirbisky-Hershberger, Jennifer L Freeman, Andrea L Kasinski, Qing Deng
MicroRNA-223 is known as a myeloid-enriched anti-inflammatory microRNA that is dysregulated in numerous inflammatory conditions. Here, we report that neutrophilic inflammation (wound response) is augmented in miR-223-deficient zebrafish, due primarily to elevated activation of the canonical nuclear factor κB (NF-κB) pathway. NF-κB over-activation is restricted to the basal layer of the surface epithelium, although miR-223 is detected throughout the epithelium and in phagocytes. Not only phagocytes but also epithelial cells are involved in miR-223-mediated regulation of neutrophils' wound response and NF-κB activation...
February 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29442990/alteration-of-microrna-expression-profiles-by-surface-modified-gold-nanoparticles-in-human-lung-adenocarcinoma-cells
#19
Seon Young Choi, Pan Dong Ryu, Sang-Woo Joo, So Yeong Lee
MicroRNAs that bind to mRNA are important post-transcriptional regulators that control gene expression by degradation or suppressing translation of target mRNAs. Several studies indicate that nanoparticles (NPs) induce alterations in microRNA expression relating to cell processes including cell development and progressive diseases. However, the alteration of microRNA expression by surface-modified gold nanoparticles (AuNPs) in A549 cells has not been reported. In order to investigate the patterns of microRNA expression, we analyzed data from microRNA arrays using cells treated with citrate- or chitosan-AuNPs...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29441983/microrna-137-promotes-hepatitis-b-virus-gene-expression-and-replication-via-targeting-the-protein-inhibitor-of-activated-stat-2
#20
Yongjie Pan, Jinhua Dai, Yufeng Liao, Qiuyun Yu
Hepatitis B virus (HBV) infection is one of the most important infectious diseases in China. In this study, we investigated the functional role of miR-137 in HBV infection to further elucidate the mechanism underlying the associated pathology. Viral replication was determined after transfection of HEK293 cells with the replication-competent vector pHBV1.3 and miR137 mimics or inhibitors. Expression of HBV genes was determined by quantitative real-time PCR (qRT-PCR). Expression of miR-137 and protein inhibitor of activated STAT 2 (PIAS2) was determined by qRT-PCR and Western blotting...
September 1, 2017: Die Pharmazie
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