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activation mediated microrna

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https://www.readbyqxmd.com/read/29663360/microrna-30d-preserves-pancreatic-islet-%C3%AE-cell-function-through-negative-regulation-of-the-jnk-signaling-pathway-via-socs3-in-mice-with-streptozotocin-induced-diabetes-mellitus
#1
Shan Wang, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Min Shen, Shao-Hua Fan, Juan Zhuang, Wei Xu, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
The loss of pancreatic islet β-cell function represents the classical feature in the pathogenesis of type 2 diabetes mellitus (T2DM). Previous evidence has highlighted the involvement of the activated JNK pathway in relation to islet β-cell apoptosis. Hence, during the present study a streptozotocin-induced DM mice model was established in a bid to ascertain as to whether microRNA-30d (miR-30d) plays a regulatory role in the JNK pathway in relation to islet β-cell dysfunction. The collection and identification of the islet β cells from streptozotocin-induced mice was performed...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29662176/cancer-cell-secreted-exosomal-mir-105-promotes-tumour-growth-through-the-myc-dependent-metabolic-reprogramming-of-stromal-cells
#2
Wei Yan, Xiwei Wu, Weiying Zhou, Miranda Y Fong, Minghui Cao, Juan Liu, Xiaojing Liu, Chih-Hong Chen, Oluwole Fadare, Donald P Pizzo, Jiawen Wu, Liang Liu, Xuxiang Liu, Andrew R Chin, Xiubao Ren, Yuan Chen, Jason W Locasale, Shizhen Emily Wang
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and buffer the negative effects of environmental changes. Extracellular microRNAs (miRNAs) have recently been implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-cancer-secreted, extracellular-vesicle-encapsulated miR-105, which is induced by the oncoprotein MYC in cancer cells and, in turn, activates MYC signalling in cancer-associated fibroblasts (CAFs) to induce a metabolic program...
April 16, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29662165/deconvolution-of-seed-and-rna-binding-protein-crosstalk-in-rnai-based-functional-genomics
#3
Hiroshi I Suzuki, Ryan M Spengler, Giedre Grigelioniene, Tatsuya Kobayashi, Phillip A Sharp
RNA interference (RNAi) is a major, powerful platform for gene perturbations, but is restricted by off-target mechanisms. Communication between RNAs, small RNAs, and RNA-binding proteins (RBPs) is a pervasive feature of cellular RNA networks. We present a crosstalk scenario, designated as crosstalk with endogenous RBPs' (ceRBP), in which small interfering RNAs or microRNAs with seed sequences that overlap RBP motifs have extended biological effects by perturbing endogenous RBP activity. Systematic analysis of small interfering RNA (siRNA) off-target data and genome-wide RNAi cancer lethality screens using 501 human cancer cell lines, a cancer dependency map, identified that seed-to-RBP crosstalk is widespread, contributes to off-target activity, and affects RNAi performance...
April 16, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29661829/microrna-27b-modulates-inflammatory-response-and-apoptosis-during-mycobacterium-tuberculosis-infection
#4
Shuxin Liang, Zhigang Song, Yongyan Wu, Yuanpeng Gao, Mingqing Gao, Fayang Liu, Fengyu Wang, Yong Zhang
Mycobacterium tuberculosis poses a significant global health threat. MicroRNAs play an important role in regulating host anti-mycobacterial defense; however, their role in apoptosis-mediated mycobacterial elimination and inflammatory response remains unclear. In this study, we explored the role of microRNA-27b (miR-27b) in murine macrophage responses to M. tuberculosis infection. We uncovered that the TLR-2/MyD88/NF-κB signaling pathway induced the expression of miR-27b and miR-27b suppressed the production of proinflammatory factors and the activity of NF-κB, thereby avoiding an excessive inflammation during M...
April 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29661250/isocitrate-dehydrogenase-1-snail-axis-dysfunction-significantly-correlates-with-breast-cancer-prognosis-and-regulates-cell-invasion-ability
#5
Wen-Shan Liu, Shih-Hsuan Chan, Hong-Tai Chang, Guan-Cheng Li, Ya-Ting Tu, Hui-Hwa Tseng, Ting-Ying Fu, Hui-Yu Chang, Huei-Han Liou, Luo-Ping Ger, Kuo-Wang Tsai
BACKGROUND: The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which serves as an important biomarker of breast cancer. However, the expression levels of the IDH protein and their biological function in human breast cancer remain largely unknown. METHODS: In this study, the clinical impact of IDH1 expression on the progression and prognosis of breast cancer was evaluated using immunohistochemistry assay (IHC) of the corresponding tumor-adjacent normal, ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC) tissues from 309 patients with breast ductal carcinoma...
April 16, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29656550/mir-181c-brk1-axis-plays-a-key-role-in-actin-cytoskeleton-dependent-t-cell-function
#6
Shok Ping Lim, Nikolaos Ioannou, Alan G Ramsay, David Darling, Joop Gäken, Ghulam J Mufti
MicroRNAs are short endogenous noncoding RNAs that play pivotal roles in a diverse range of cellular processes. The miR-181 family is important in T cell development, proliferation, and activation. In this study, we have identified BRK1 as a potential target of miR-181c using a dual selection functional assay and have showed that miR-181c regulates BRK1 by translational inhibition. Given the importance of miR-181 in T cell function and the potential role of BRK1 in the involvement of WAVE2 complex and actin polymerization in T cells, we therefore investigated the influence of miR-181c-BRK1 axis in T cell function...
April 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29655703/the-effects-of-wild-bitter-gourd-fruit-extracts-on-icam-1-expression-in-pulmonary-epithelial-cells-of-c57bl-6j-mice-and-microrna-221-222-knockout-mice-involvement-of-the-mir-221-222-pi3k-akt-nf-%C3%AE%C2%BAb-pathway
#7
Hsin-Ching Sung, Chen-Wei Liu, Chien-Yu Hsiao, Shu-Rung Lin, I-Shing Yu, Shu-Wha Lin, Ming-Hsien Chiang, Chan-Jung Liang, Chi-Ming Pu, Yu-Chen Chen, Ming-Shian Lin, Yuh-Lien Chen
BACKGROUND: The extracts from wild bitter gourd fruit (WBGE) were reported to possess numerous pharmacological activities. However, the anti-inflammatory effects of WBGE on human lung epithelial cells and the underlying mechanisms have not been determined. PURPOSE: To evaluate the molecular basis of the effects of WBGE on intercellular adhesion molecule-1 (ICAM-1) expression in alveolar epithelial (A549) cells, C57BL/6 wild-type (WT) mice and microRNA (miR)-221/-222 knockout (KO) mice with or without tumor necrosis factor (TNF-α; 3 ng/ml) treatment...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29653464/microrna-130b-targets-pten-to-induce-resistance-to-cisplatin-in-lung-cancer-cells-by-activating-wnt-%C3%AE-catenin-pathway
#8
Qiang Zhang, Bin Zhang, Leina Sun, Qingna Yan, Yu Zhang, Zhenfa Zhang, Yanjun Su, Changli Wang
More and more studies indicate the relevance of miRNAs in inducing certain drug resistance. Our study aimed to investigate whether microRNA-130b-3p (miR-130b) mediates the chemoresistance as well as proliferation of lung cancer (LC) cells. MTS assay and apoptosis analysis were conducted to determine cell proliferation and apoptosis, respectively. Binding sites were identified using a luciferase reporter system, whereas mRNA and protein expression of target genes was determined by RT-PCR and immunoblot, respectively...
April 13, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29653269/microrna-26a-is-a-key-regulon-that-inhibits-progression-and-metastasis-of-c-myc-ezh2-double-high-advanced-hepatocellular-carcinoma
#9
Xiang Zhang, Xiao Zhang, Ting Wang, Lei Wang, Zhijun Tan, Wei Wei, Bo Yan, Jing Zhao, Kaichun Wu, Angang Yang, Rui Zhang, Lintao Jia
Overexpressed c-Myc and EZH2 usually mean high malignancy in cancers. Most of mortality from cancer is attributable to metastasis. MicroRNAs(miRNAs), like transcription factors, can regulate hundreds of genes. Here, we identify microRNA-26a (miR-26a) suppresses EZH2 and c-Myc by targeting EZH2 and CDK8 in Wnt pathway. MiR-26a is a well-known tumor-suppressive miRNA in multiple cancers, but how it is downregulated in hepatocellular carcinoma (HCC) is still unclear. Here, we disclose miR-26a is epigenetic silenced by a c-Myc-mediated PRC2-depandent way in HCC...
April 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29651283/mirnas-in-tuberculosis-new-avenues-for-diagnosis-and-host-directed-therapy
#10
REVIEW
Naveed Sabir, Tariq Hussain, Syed Zahid Ali Shah, Antonio Peramo, Deming Zhao, Xiangmei Zhou
Tuberculosis (TB) is one of the most fatal infectious diseases and a leading cause of mortality, with 95% of these deaths occurring in developing countries. The causative agent, Mycobacterium tuberculosis ( Mtb ), has a well-established ability to circumvent the host's immune system for its intracellular survival. microRNAs (miRNAs) are small, non-coding RNAs having an important function at the post-transcriptional level and are involved in shaping immunity by regulating the repertoire of genes expressed in immune cells...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29650590/coordination-of-meristem-and-boundary-functions-by-transcription-factors-in-the-shoot-meristemless-regulatory-network
#11
S Scofield, A Murison, A Jones, J Fozard, M Aida, L R Band, M Bennett, J A H Murray
The Arabidopsis homeodomain transcription factor SHOOT MERISTEMLESS (STM) is critical for shoot apical meristem (SAM) function, yet the components and structure of the STM gene regulatory network (GRN) are largely unknown. Here we show that transcriptional regulators are overrepresented amongst STM-regulated genes, and using these as GRN components in Bayesian network analysis we infer STM GRN associations and reveal regulatory relationships between STM and factors involved in multiple aspects of SAM function, including hormone regulation, TCP-mediated control of cell differentiation, AIL/PLT-mediated regulation of pluripotency and phyllotaxis, and specification of meristem-organ boundary zones via CUC1...
April 12, 2018: Development
https://www.readbyqxmd.com/read/29629073/construction-of-an-autonomously-concatenated-hybridization-chain-reaction-for-signal-amplification-and-intracellular-imaging
#12
Jie Wei, Xue Gong, Qing Wang, Min Pan, Xiaoqing Liu, Jing Liu, Fan Xia, Fuan Wang
Biomolecular self-assembly has spurred substantial research efforts for the development of low-cost point-of-care diagnostics. Herein, we introduce an isothermal enzyme-free concatenated hybridization chain reaction (C-HCR), in which the output of the upstream hybridization chain reaction (HCR-1) layer acts as an intermediate input to activate the downstream hybridization chain reaction (HCR-2) layer. The initiator motivates HCR-1 through the autonomous cross-opening of two functional DNA hairpins, yielding polymeric dsDNA nanowires composed of numerous tandem triggers T as output of the primary sensing event...
January 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29627294/%C3%AE-arrestin-biased-agonism-of-%C3%AE-adrenergic-receptor-regulates-dicer-mediated-microrna-maturation-to-promote-cardioprotective-signaling
#13
Jian-Peng Teoh, Ahmed S Bayoumi, Tatsuya Aonuma, Yanyan Xu, John A Johnson, Huabo Su, Neal L Weintraub, Yaoliang Tang, Il-Man Kim
RATIONALE: MicroRNAs (miRs) are small, non-coding RNAs that function to post-transcriptionally regulate target genes. First transcribed as primary miR transcripts (pri-miRs), they are enzymatically processed by Drosha into premature miRs (pre-miRs) and further cleaved by Dicer into mature miRs. Initially discovered to desensitize β-adrenergic receptor (βAR) signaling, β-arrestins are now well-appreciated to modulate multiple pathways independent of G protein signaling, a concept known as biased signaling...
April 6, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29626383/micrornp-mediated-translational-activation-of-nonadenylated-mrnas-in-a-mammalian-cell-free-system
#14
Motoaki Wakiyama, Koichi Ogami, Ryo Iwaoka, Kazuma Aoki, Shin-Ichi Hoshino
MicroRNAs are small noncoding RNAs that regulate translation and mRNA stability by binding target mRNAs in complex with Argonaute (AGO) proteins. AGO interacts with a member of the TNRC6 family proteins to form a microRNP complex, which recruits the CCR4-NOT complex to accelerate deadenylation and inhibits translation. MicroRNAs primarily repress translation of target mRNAs but have been shown to enhance translation of a specific type of target reporter mRNAs in various experimental systems: G0 quiescent mammalian cells, Xenopus laevis oocytes, Drosophila embryo extracts, and HeLa cells...
April 6, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29621782/enhanced-pro-inflammatory-response-of-macrophages-to-interleukin-33-in-an-allergic-environment
#15
Noel Chia, Rakesh K Kumar, Paul S Foster, Cristan Herbert
BACKGROUND: Allergic asthma is common in childhood and is associated with a T-helper type 2 (Th2)-biased immunological response. Exacerbations of asthma are characterised by increased inflammation of the airways, which appears to be driven by interleukin (IL)-33 that can activate pulmonary macrophages. The Th2 cytokine environment of allergic asthma may contribute to exaggerated airway inflammation. OBJECTIVES: To test this, we assessed whether production of pro-inflammatory cytokines by IL-33-stimulated macrophages was enhanced in cells pre-treated with the key Th2 cytokines IL-4 and IL-13...
April 5, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29620442/mir-21-stat3-signal-is-involved-in-odontoblast-differentiation-of-human-dental-pulp-stem-cells-mediated-by-tnf-%C3%AE
#16
Ke Xu, Jingwen Xiao, Ke Zheng, Xingmei Feng, Jinlong Zhang, Donghui Song, Chenfei Wang, Xiang Shen, Xin Zhao, Changbo Wei, Dan Huang, Guijuan Feng
Dental pulp stem cells (DPSCs), as one type of mesenchymal stem cells (MSCs), have the capability of self-renewal and multipotency to differentiate into several cell lineages, including osteogenesis, odontoblasts, chondrogenesis, neurogenesis, and adipogenesis. It has found that tumor necrosis factor-α (TNF-α) can promote osteogenic differentiation of human DPSCs in our previous studies. Other experimentation revealed that signal transducer and activator of transcription 3 (STAT3) underwent a rapid activation both in osteogenesis and inflammation microenvironment of MSCs in vitro...
April 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29620271/mir%C3%A2-152-regulates-tgf%C3%A2-%C3%AE-1%C3%A2-induced-epithelial%C3%A2-mesenchymal-transition-by-targeting-hpip-in-tubular-epithelial-cells
#17
Ya-Xian Ning, Xiao-Yuan Wang, Jian-Qin Wang, Rong Zeng, Gou-Qin Wang
Renal fibrosis is a common pathological feature of chronic kidney diseases, and their development and progression are influenced by epigenetic modifications including aberrant microRNA (miRNA or miR) expression. miRNAs have been demonstrated to modulate the aggressiveness of various cancers and have emerged as possible therapeutic agents for the management of renal fibrosis. Transforming growth factor β1 (TGF‑β1)‑induced epithelial‑mesenchymal transition (EMT) of tubular epithelial cells serves a role in the initiation and progression of renal fibrosis...
April 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29620230/formononetin-inhibits-colon-carcinoma-cell-growth-and-invasion-by-microrna%C3%A2-149%C3%A2-mediated-ephb3-downregulation-and-inhibition-of-pi3k-akt-and-stat3-signaling-pathways
#18
Ai-Lei Wang, Yong Li, Qun Zhao, Li-Qiao Fan
Formononetin (Form), a phytoestrogen extracted from the roots of Astragalus membranaceus, is one of the fundamental herbs used in traditional Chinese medicine because of its protective effects against certain malignant tumors. However, its role in colon carcinoma cells and the underlying molecular mechanisms have not been completely elucidated. The present study aimed to demonstrate that Form significantly inhibited the proliferation and invasion of the colon carcinoma cell lines SW1116 and HCT116. Mechanistic studies have suggested that Form suppresses colon carcinoma cell growth by downregulating cell cycle‑associated protein (cyclin D1) expression and arresting the cell cycle at the G0‑G1 checkpoint...
April 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29620201/microrna%C3%A2-92a-overexpression-promotes-the-osteogenic-differentiation-of-bone-mesenchymal-stem-cells-by-impeding-smad6%C3%A2-mediated-runt%C3%A2-related-transcription-factor-2-degradation
#19
Xu Yan, Hao Wang, Yufei Li, Yuxin Jiang, Qingdong Shao, Weidong Xu
Bone mesenchymal stem cells (BMSCs) are an important source of stem cells for tissue repair and regeneration; therefore, understanding the mechanisms that regulate stem cell differentiation in a specific lineage is critical. Runt‑related transcription factor 2 (Runx2) is a bone‑specific transcription factor that serves an important role in promoting osteogenic differentiation. However, Runx2 protein levels are regulated by the ubiquitin‑proteasome pathway. Previous research has identified that Smad6 can interact with Runx2 and enhance Smurf1‑induced Runx2 degradation in a ubiquitin‑proteasome‑dependent manner...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29618288/upregulation-of-mir-212-inhibits-migration-and-tumorigenicity-and-inactivates-wnt-%C3%AE-catenin-signaling-in-human-hepatocellular-carcinoma
#20
Pengbo Jia, Guangbing Wei, Cancan Zhou, Qi Gao, Yunhua Wu, Xuejun Sun, Xuqi Li
BACKGROUND: MicroRNAs are involved in hepatocellular carcinoma metastasis, a principal cause of hepatocellular carcinoma-related death in patients worldwide. MiR-212 is a microRNA that has been identified in several types of cancers and is postulated to influence cell signaling and subsequent malignant pathogenesis. Despite emerging reports suggesting that miR-212 plays a significant role in the onset, progression, and migration of these types of malignant tumors, its involvement in the development of hepatocellular carcinoma has not been fully elucidated...
January 1, 2018: Technology in Cancer Research & Treatment
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