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https://www.readbyqxmd.com/read/29042411/a-horizontally-transferred-autonomous-helitron-became-a-full-polydnavirus-segment-in-cotesia-vestalis
#1
Pedro Heringer, Guilherme B Dias, Gustavo C S Kuhn
Bracoviruses associate symbiotically with thousands of parasitoid wasp species in the family Braconidae, working as virulence gene vectors, and allowing the development of wasp larvae within hosts. These viruses are composed by multiple DNA circles that are packaged into infective particles and injected together with wasp's eggs during parasitization. One of the viral segments of Cotesia vestalis bracovirus contains a gene that has been previously described as a helicase of unknown origin. Here we demonstrate that this gene is a Rep/Helicase from an intact Helitron transposable element that covers the viral segment almost entirely...
October 17, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29038015/why-is-there-no-impact-of-the-host-species-on-the-cold-tolerance-of-a-generalist-parasitoid
#2
Lucy Alford, Hossein Kishani Farahani, Jean-Sébastien Pierre, Françoise Burel, Joan van Baaren
For generalist parasitoids such as those belonging to the Genus Aphidius, the choice of host species can have profound implications for the emerging parasitoid. Host species is known to affect a variety of life history traits. However, the impact of the host on thermal tolerance has never been studied. Physiological thermal tolerance, enabling survival at unfavourable temperatures, is not a fixed trait and may be influenced by a number of external factors including characteristics of the stress, of the individual exposed to the stress, and of the biological and physical environment...
October 13, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29030993/maternal-provision-of-non-sex-specific-transformer-messenger-rna-in-sex-determination-of-the-wasp-asobara-tabida
#3
E Geuverink, E C Verhulst, M van Leussen, L van de Zande, L W Beukeboom
In many insect species maternal provision of sex-specifically spliced messenger RNA (mRNA) of sex determination genes is an essential component of the sex determination mechanism. In haplodiploid Hymenoptera, maternal provision in combination with genomic imprinting has been shown for the parasitoid Nasonia vitripennis, known as maternal effect genomic imprinting sex determination (MEGISD). Here, we characterize the sex determination cascade of Asobara tabida, another hymenopteran parasitoid. We show the presence of the conserved sex determination genes doublesex (dsx), transformer (tra) and transformer-2 (tra2) orthologues in As...
October 14, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/29029091/cockroach-oothecal-parasitoid-evania-appendigaster-hymenoptera-evaniidae-exhibits-oviposition-preference-towards-oothecal-age-most-vulnerable-to-host-cannibalism
#4
Hui-Siang Tee, Chow-Yang Lee
Many female parasitoid wasps optimize host selection to balance the benefits of high-quality hosts and the costs of predator- or hyperparasitoid-induced mortality risks to maximize their fitness. Cannibalism exists in many insect species and affects survival of parasitoid larvae developing in or on parasitized hosts. However, little is known about how parasitoid wasps resolve the fitness consequence of host cannibalism-induced mortality risk during host selection. We examined the effect of oothecal age on cannibalism in the American cockroach Periplaneta americana (L...
September 27, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29028594/observation-of-intra-and-interspecific-differences-in-the-nest-chemical-profiles-of-social-wasps-hymenoptera-polistinae-using-infrared-photoacoustic-spectroscopy
#5
Denise Sguarizi-Antonio, Viviana O Torres, Ellen L B Firmino, Sandro M Lima, Luis H C Andrade, William F Antonialli-Junior
The aim of this study was to explore whether the nest chemical profile (NCP) can be used to determine intra- and interspecific differences in social wasps of the subfamily Polistinae. For this purpose, Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS) was used to directly analyze small pieces of nest as well as the gasters of females. An advantage of the methodology was that no sample preparation was required. FTIR-PAS combined with multivariate discriminant analyzes was used, to the best of our knowledge for the first time, to evaluate the NCPs of six species of polistine wasps, observing the influence of the nesting environment and investigating the relationships among the nest and female cuticular chemical profiles...
October 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29027924/anti-salmonella-activity-modulation-of-mastoparan-v1-a-wasp-venom-toxin-using-protease-inhibitors-and-its-efficient-production-via-an-escherichia-coli-secretion-system
#6
Yeon Jo Ha, Sam Woong Kim, Chae Won Lee, Chang-Hwan Bae, Joo-Hong Yeo, Il-Suk Kim, Sang Wan Gal, Jin Hur, Ho-Kyoung Jung, Min-Ju Kim, Woo Young Bang
A previous study highlighted that mastoparan V1 (MP-V1), a mastoparan from the venom of the social wasp Vespula vulgaris, is a potent antimicrobial peptide against Salmonella infection, which causes enteric diseases. However, there exist some limits for its practical application due to the loss of its activity in an increased bacterial density and the difficulty of its efficient production. In this study, we first modulated successfully the antimicrobial activity of synthetic MP-V1 against an increased Salmonella population using protease inhibitors, and developed an Escherichia coli secretion system efficiently producing active MP-V1...
October 13, 2017: Toxins
https://www.readbyqxmd.com/read/29022901/bcr-abl1-induced-downregulation-of-wasp-in-chronic-myeloid-leukemia-involves-epigenetic-modification-and-contributes-to-malignancy
#7
Welbert O Pereira, Daniel D De Carvalho, Maria Emilia Zenteno, Beatriz F Ribeiro, Jacqueline F Jacysyn, Luiz R Sardinha, Maria A Zanichelli, Nelson Hamerschlak, Gareth E Jones, Katia B Pagnano, Fabiola A Castro, Yolanda Calle, Gustavo P Amarante-Mendes
Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by the BCR-ABL1 tyrosine kinase (TK). The development of TK inhibitors (TKIs) revolutionized the treatment of CML patients. However, TKIs are not effective to those at advanced phases when amplified BCR-ABL1 levels and increased genomic instability lead to secondary oncogenic modifications. Wiskott-Aldrich syndrome protein (WASP) is an important regulator of signaling transduction in hematopoietic cells and was shown to be an endogenous inhibitor of the c-ABL TK...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29020022/the-geological-record-and-phylogeny-of-spider-wasps-hymenoptera-pompilidae-a-revision-of-fossil-species-and-their-phylogenetic-placement
#8
Juanita Rodriguez, Cecilia Waichert, Carol D von Dohlen, James P Pitts
Accurate fossil identification has become increasingly relevant with the widespread use of phylogenetic divergence time estimation methods, which rely on fossil data to determine clade hard-minimum ages. Here we revise, diagnose and illustrate known spider wasp (Hymenoptera: Pompilidae) fossil species and place them within the latest Pompilidae phylogenetic hypothesis. Ceropalites infelix Cockerell, from the Florissant Fossil Beds (Priabonian), is no longer recognized as Pompilidae, but as Aulacidae. Agenioideus saxigenus (Cockerell) comb...
2017: PloS One
https://www.readbyqxmd.com/read/29019464/ovipositor-inspired-steerable-needle-design-and-preliminary-experimental-evaluation
#9
Marta Scali, Tim Philipp Pusch, Paul Breedveld, D Dodou
Flexible steerable needles have the potential to allow surgeons to reach deep targets inside the human body with higher accuracy than rigid needles do. Furthermore, by maneuvering around critical anatomical structures, steerable needles could limit the risk of tissue damage. However, the design of a thin needle (e.g., diameter under 2 mm) with a multi-direction steering mechanism is challenging. The goal of this paper is to outline the design and experimental evaluation of a biologically inspired needle with a diameter under 2 mm that advances through straight and curved trajectories in a soft substrate without being pushed, without buckling, and without the need of axial rotation...
October 11, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28994726/trap-nesting-wasps-and-bees-in-agriculture-a-comparison-of-sown-wildflower-and-fallow-plots-in-florida
#10
Joshua W Campbell, Cherice Smithers, Allyn Irvin, Chase B Kimmel, Cory Stanley-Stahr, Jaret C Daniels, James D Ellis
Wildflower strip plantings in intensive agricultural systems have become a widespread tool for promoting pollination services and biological conservation because of their use by wasps and bees. Many of the trap-nesting wasps are important predators of common crop pests, and cavity-nesting bees that utilize trap-nests are important pollinators for native plants and many crops. The impact of wildflower strips on the nesting frequency of trap-nesting wasps or bees within localized areas has not been thoroughly investigated...
October 10, 2017: Insects
https://www.readbyqxmd.com/read/28972183/the-actin-related-p41arc-subunit-contributes-to-p21-activated-kinase-1-pak1-mediated-glucose-uptake-into-skeletal-muscle-cells
#11
Ragadeepthi Tunduguru, Jing Zhang, Arianne Aslamy, Vishal A Salunkhe, Joseph T Brozinick, Jeffrey S Elmendorf, Debbie C Thurmond
Defects in translocation of the glucose transporter GLUT4 are associated with peripheral insulin resistance, pre-clinical diabetes, and progression to type 2 diabetes. GLUT4 recruitment to the plasma membrane of skeletal muscle cells requires filamentous (F)-actin remodeling. Insulin signaling in muscle requires p21-activated kinase-1 (PAK1), whose downstream signaling triggers actin remodeling that promotes GLUT4 vesicle translocation and glucose uptake into skeletal muscle cells. Actin remodeling is a cyclic process, and while PAK1 is known to initiate changes to the cortical actin-binding protein cofilin to stimulate the depolymerizing arm of the cycle, how PAK1 might trigger the polymerizing arm of the cycle remains unresolved...
September 25, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28968508/functional-genomics-in-the-wild-a-case-study-with-paper-wasps-shows-challenges-and-prospects-for-rna-interference-in-ecological-systems
#12
Susan Weiner, Amy Geffre, Amy Lynn Toth
RNA-interference (RNAi) is a useful tool to assess gene function by knocking down expression of a target gene, and has been used successfully in domestic and laboratory organisms. However, RNAi for functional genomics has not fully extended into ecological model organisms in natural environments. Assessment of gene function in the wild is important, because gene function can be environmentally and context-dependent. Here, we present a case study using RNAi to assess gene function in wild paper wasps Polistes metricus, to test roles for two candidate genes (NADH dehydrogenase and Retinoid and fatty acid binding protein) in the development of reproductive castes...
October 2, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28966433/an-integrated-ecological-modeling-system-for-assessing-impacts-of-multiple-stressors-on-stream-and-riverine-ecosystem-services-within-river-basins
#13
John M Johnston, M Craig Barber, Kurt Wolfe, Mike Galvin, Mike Cyterski, Rajbir Parmar
We demonstrate a novel, spatially explicit assessment of the current condition of aquatic ecosystem services, with limited sensitivity analysis for the atmospheric contaminant mercury. The Integrated Ecological Modeling System (IEMS) forecasts water quality and quantity, habitat suitability for aquatic biota, fish biomasses, population densities, productivities, and contamination by methylmercury across headwater watersheds. We applied this IEMS to the Coal River Basin (CRB), West Virginia (USA), an 8-digit hydrologic unit watershed, by simulating a network of 97 stream segments using the SWAT watershed model, a watershed mercury loading model, the WASP water quality model, the PiSCES fish community estimation model, a fish habitat suitability model, the BASS fish community and bioaccumulation model, and an ecoservices post-processer...
June 24, 2017: Ecological Modelling
https://www.readbyqxmd.com/read/28965764/-methylthio-phenol-semiochemicals-are-exploited-by-deceptive-orchids-as-sexual-attractants-for-campylothynnus-thynnine-wasps
#14
Björn Bohman, Ryan D Phillips, Gavin R Flematti, Rod Peakall
Until recently, (methylthio)phenols as natural products had only been reported from bacteria. Now, four representatives of this class of sulfurous aromatic compounds have been discovered as semiochemicals in the orchid Caladenia crebra, which secures pollination by sexual deception. In this case, field bioassays confirmed that a 10:1 blend of 2-(methylthio)benzene-1,4-diol (1) and 4-hydroxy-3-(methylthio)benzaldehyde (2) sexually attracts the male thynnine wasp Campylothynnus flavopictus (Tiphiidae:Thynnineae), the exclusive pollinator of C...
September 28, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28965321/pro-necrotic-activity-of-cationic-mastoparan-peptides-in-human-glioblastoma-multiforme-cells-via-membranolytic-action
#15
Annielle Mendes Brito da Silva, Laíz Costa Silva-Gonçalves, Fernando Augusto Oliveira, Manoel Arcisio-Miranda
Glioblastoma multiforme is the most common and lethal malignant brain tumor. Because of its complexity and heterogeneity, this tumor has become resistant to conventional therapies and the available treatment produces multiple side effects. Here, using multiple experimental approaches, we demonstrate that three mastoparan peptides-Polybia-MP1, Mastoparan X, and HR1-from solitary wasp venom exhibit potent anticancer activity toward human glioblastoma multiforme cells. Importantly, the antiglioblastoma action of mastoparan peptides occurs by membranolytic activity, leading to necrosis...
September 30, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28961272/sorbin-and-sh3-domain-containing-protein-2-sorbs2-is-a-component-of-the-acto-myosin-ring-at-the-apical-junctional-complex-in-epithelial-cells
#16
Karin Fredriksson-Lidman, Christina M Van Itallie, Amber J Tietgens, James M Anderson
SORBS2 is a scaffolding protein associated with Abl/Arg non-receptor tyrosine kinase pathways and is known to interact with actin and several other cytoskeletal proteins in various cell types. Previous BioID proximity labeling of tight and adherens junction proteins suggested that SORBS2 is a component of the apical junction complex of epithelial cells. We asked whether SORBS2 plays a previously unappreciated role in controlling perijunctional actin and tight junction barrier function. Using super resolution imaging we confirmed that SORBS2 is localized at the apical junction complex but farther from the membrane than ZO-1 and located partially overlapping both the tight- and adherens junctions with a periodic concentration that alternates with myosin IIB in polarized epithelial cells...
2017: PloS One
https://www.readbyqxmd.com/read/28956077/are-the-ttagg-and-ttaggg-telomeric-repeats-phylogenetically-conserved-in-aculeate-hymenoptera
#17
Rodolpho S T Menezes, Vanessa B Bardella, Diogo C Cabral-de-Mello, Daercio A A Lucena, Eduardo A B Almeida
Despite the (TTAGG)n telomeric repeat supposed being the ancestral DNA motif of telomeres in insects, it was repeatedly lost within some insect orders. Notably, parasitoid hymenopterans and the social wasp Metapolybia decorata (Gribodo) lack the (TTAGG)n sequence, but in other representatives of Hymenoptera, this motif was noticed, such as different ant species and the honeybee. These findings raise the question of whether the insect telomeric repeat is or not phylogenetically predominant in Hymenoptera. Thus, we evaluated the occurrence of both the (TTAGG)n sequence and the vertebrate telomere sequence (TTAGGG)n using dot-blotting hybridization in 25 aculeate species of Hymenoptera...
September 27, 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/28955984/expression-of-n-wasp-is-regulated-by-hif1%C3%AE-through-the-hypoxia-response-element-in-the-n-wasp-promoter
#18
Amrita Salvi, Thirumaran Thanabalu
Cancer cell migration and invasion involves temporal and spatial regulation of actin cytoskeleton reorganization, which is regulated by the WASP family of proteins such as N-WASP (Neural- Wiskott Aldrich Syndrome Protein). We have previously shown that expression of N-WASP was increased under hypoxic conditions. In order to characterize the regulation of N-WASP expression, we constructed an N-WASP promoter driven GFP reporter construct, N-WASP(pro)-GFP. Transfection of N-WASP(pro)-GFP construct and plasmid expressing HiF1α (Hypoxia Inducible factor 1α) enhanced the expression of GFP suggesting that increased expression of N-WASP under hypoxic conditions is mediated by HiF1α...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28947957/cooperative-but-distinct-early-co-signaling-events-originate-from-erbb2-and-erbb1-receptors-upon-trastuzumab-treatment-in-breast-cancer-cells
#19
Paola Bagnato, Alessia Castagnino, Katia Cortese, Maria Bono, Silvia Grasso, Grazia Bellese, Tiziana Daniele, Richard Lundmark, Paola Defilippi, Patrizio Castagnola, Carlo Tacchetti
ERBB2 receptor belongs to the ERBB tyrosine kinase receptor family. At variance to the other family members, ERBB2 is a constitutively active orphan receptor. Upon ligand binding and activation, ERBB receptors form homo- or hetero-dimers with the other family members, including ERBB2, promoting an intracellular signaling cascade. ERBB2 is the preferred dimerization partner and ERBB2 heterodimers signaling is stronger and longer acting compared to heterodimers between other ERBB members. The specific contribution of ERBB2 in heterodimer signaling is still undefined...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938568/senp3-grants-tight-junction-integrity-and-cytoskeleton-architecture-in-mouse-sertoli-cells
#20
Di Wu, Chun-Jie Huang, Faheem Ahmed Khan, Xiao-Fei Jiao, Xiao-Ming Liu, Nuruliarizki Shinta Pandupuspitasari, Rahim Dad Brohi, Li-Jun Huo
Germ cells develop in a sophisticated immune privileged microenvironment provided by specialized junctions contiguous the basement membrane of the adjacent Sertoli cells that constituted the blood-testis barrier (BTB) in seminiferous epithelium of testis in mammals. Deciphering the molecular regulatory machinery of BTB activity is central to improve male fertility and the role of post-translational modification including SUMOylation pathway is one of the key factors. Herein, we unveiled the mystery of the SUMO-2/3 specific protease SENP3 (Sentrin-specific protease 3) in BTB dynamics regulation...
August 29, 2017: Oncotarget
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