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https://www.readbyqxmd.com/read/28917022/epidemiology-pathogenesis-and-management-of-takotsubo-syndrome
#1
REVIEW
Shams Y-Hassan, Per Tornvall
Takotsubo syndrome is a recently recognized acute cardiac disease entity with a clinical presentation resembling that of an acute coronary syndrome. The typical takotsubo syndrome patient has a unique circumferential left (bi-) ventricular contraction abnormality profile that extends beyond a coronary artery supply territory and appears to follow the anatomical cardiac sympathetic innervation. The syndrome predominantly affects postmenopausal women and is often preceded by emotional or physical stress. Patients with predisposing factors such as malignancy and other chronic comorbidities are more prone to suffer from takotsubo syndrome...
September 15, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28915333/air-pollution-and-other-environmental-modulators-of-cardiac-function
#2
Matthew W Gorr, Michael J Falvo, Loren E Wold
Cardiovascular disease (CVD) is the leading cause of death in developed regions and a worldwide health concern. Multiple external causes of CVD are well known, including obesity, diabetes, hyperlipidemia, age, and sedentary behavior. Air pollution has been linked with the development of CVD for decades, though the mechanistic characterization remains unknown. In this comprehensive review, we detail the background and epidemiology of the effects of air pollution and other environmental modulators on the heart, including both short- and long-term consequences...
September 12, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28912179/classification-epidemiology-and-global-burden-of-cardiomyopathies
#3
REVIEW
William J McKenna, Barry J Maron, Gaetano Thiene
In the past 25 years, major advances were achieved in the nosography of cardiomyopathies, influencing the definition and taxonomy of this important chapter of cardiovascular disease. Nearly, 50% of patients dying suddenly in childhood or adolescence or undergoing cardiac transplantation are affected by cardiomyopathies. Novel cardiomyopathies have been discovered (arrhythmogenic, restrictive, and noncompacted) and added to update the World Health Organization classification. Myocarditis has also been named inflammatory cardiomyopathy...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28904174/in-hospital-outcomes-of-tumor-lysis-syndrome-a-population-based-study-using-the-national-inpatient-sample
#4
Urshila Durani, Nilay D Shah, Ronald S Go
The epidemiology and outcomes of tumor lysis syndrome (TLS) are understudied. We used the National Inpatient Sample (NIS), a nationally representative weighted sample of all U.S. hospital discharges, to study outcomes and predictors of mortality in hospitalized patients with TLS. The NIS was queried for patients with a discharge diagnosis of TLS (ICD-9 code 277.88) from 2010-2013. Baseline characteristics and outcomes were analyzed. A multivariable logistic regression analysis was performed to identify predictors of mortality...
September 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28881261/cardiorenal-syndrome-in-sepsis-a-narrative-review
#5
REVIEW
Aditya Kotecha, Saraschandra Vallabhajosyula, Hongchuan H Coville, Kianoush Kashani
Multi-organ dysfunction is seen in nearly 40-60% of all patients presenting with sepsis, including renal and cardiac dysfunction. Cardiorenal syndrome type-5 reflects concomitant cardiac and renal dysfunction secondary to a systemic condition that primarily affects both organs, such as sepsis. There are limited data on the etiology, pathogenesis and clinical implications of cardiorenal syndrome in sepsis. Cardiac dysfunction and injury can be measured with cardiac biomarkers, echocardiographic dysfunction, and hemodynamic parameters...
September 1, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28869251/cardiac-surgery-associated-acute-kidney-injury-risk-factors-pathophysiology-and-treatment
#6
REVIEW
Ying Wang, Rinaldo Bellomo
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the most common clinically important complication in adult patients undergoing open heart surgery, and is associated with increased mortality and morbidity. In patients in intensive care units, CSA-AKI is the second most common type of AKI after septic AKI. In this Review, we explore the definition of CSA-AKI, discuss its epidemiology and identify its risk factors. We discuss current theories of the pathophysiology of CSA-AKI and describe its clinical course...
September 4, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28865333/assessing-mood-symptoms-through-heartbeat-dynamics-an-hrv-study-on-cardiosurgical-patients
#7
Claudio Gentili, Simone Messerotti Benvenuti, Daniela Palomba, Alberto Greco, Enzo Pasquale Scilingo, Gaetano Valenza
BACKGROUND: Heart Rate Variability (HRV) is reduced both in depression and in coronary heart disease (CHD) suggesting common pathophysiological mechanisms for the two disorders. Within CHD, cardiac surgery patients (CSP) with postoperative depression are at greater risk of adverse cardiac events. Therefore, CSP would especially benefit from depression early diagnosis. Here we tested whether HRV-multi-feature analysis discriminates CSP with or without depression and provides an effective estimation of symptoms severity...
August 26, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28863043/pediatric-tandem-therapeutic-apheresis-a-multidisciplinary-approach
#8
Rachel M Sirignano, Erin K Meyer, Ross Fasano, Matthew L Paden
The epidemiology, safety, and efficacy of pediatric multiple tandem extracorporeal therapies are not well understood. We conducted a retrospective chart review of therapeutic apheresis (TA) from January 1, 2012 to October 31, 2015. We collected procedural/clinical demographics, American Society for Apheresis (ASFA) indication, complications, and mortality. One hundred eighty tandem TA procedures were performed in 53 patients. Median age was 9 years (range: 2 months to 21 years) with a median weight of 28 kg (range: 6-170...
August 31, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28860318/reducing-the-global-burden-of-cardiovascular-disease-part-1-the-epidemiology-and-risk-factors
#9
REVIEW
Philip Joseph, Darryl Leong, Martin McKee, Sonia S Anand, Jon-David Schwalm, Koon Teo, Andrew Mente, Salim Yusuf
Current global health policy goals include a 25% reduction in premature mortality from noncommunicable diseases by 2025. In this 2-part review, we provide an overview of the current epidemiological data on cardiovascular diseases (CVD), its risk factors, and describe strategies aimed at reducing its burden. In part 1, we examine the global epidemiology of cardiac conditions that have the greatest impact on CVD mortality; the predominant risk factors; and the impact of upstream, societal health determinants (eg, environmental factors, health policy, and health systems) on CVD...
September 1, 2017: Circulation Research
https://www.readbyqxmd.com/read/28859338/human-brain-abnormalities-associated-with-prenatal-alcohol-exposure-and-fetal-alcohol-spectrum-disorder
#10
Jessica S Jarmasz, Duaa A Basalah, Albert E Chudley, Marc R Del Bigio
Fetal alcohol spectrum disorder (FASD) is a common neurodevelopmental problem, but neuropathologic descriptions are rare and focused on the extreme abnormalities. We conducted a retrospective survey (1980-2016) of autopsies on 174 individuals with prenatal alcohol exposure or an FASD diagnosis. Epidemiologic details and neuropathologic findings were categorized into 5 age groups. Alcohol exposure was difficult to quantify. When documented, almost all mothers smoked tobacco, many abused other substances, and prenatal care was poor or nonexistent...
September 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28859022/embolic-stroke-of-undetermined-source-in-latin-america-a-review
#11
Carlos Cantú-Brito, Gisele Sampaio Silva, Sebastián F Ameriso
BACKGROUND: Stroke is a major health concern throughout Latin America. As elsewhere, no precise cause can be determined for a substantial portion of strokes. In 6 studies since 2010 in the region, 16% to 43% of ischemic strokes were identified as cryptogenic. The term embolic stroke of undetermined source (ESUS) has been proposed as more clinically useful and positively defined than the vague term cryptogenic. The epidemiology of ESUS in Latin America is largely unknown. REVIEW SUMMARY: This article aims to provide a description of the epidemiology of ESUS in Latin America and practical information regarding available diagnostic procedures and current guidelines...
September 2017: Neurologist
https://www.readbyqxmd.com/read/28856940/effects-of-human-recombinant-growth-hormone-on-exercise-capacity-cardiac-structure-and-cardiac-function-in-patients-with-adult-onset-growth-hormone-deficiency
#12
S Gonzalez, J D Windram, T Sathyapalan, Z Javed, A L Clark, S L Atkin
Objective Epidemiological studies suggest that adult-onset growth hormone deficiency (AGHD) might increase the risk of death from cardiovascular causes. Methods This was a 6-month double-blind, placebo-controlled, randomised, cross-over trial followed by a 6-month open-label phase. Seventeen patients with AGHD received either recombinant human growth hormone (rGH) (0.4 mg injection daily) or placebo for 12 weeks, underwent washout for 2 weeks, and were then crossed over to the alternative treatment for a further 12 weeks...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28855435/nationwide-survey-of-patients-with-giant-coronary-aneurysm-secondary-to-kawasaki-disease-1999-2010-in-japan
#13
Ryuji Fukazawa, Tohru Kobayashi, Masashi Mikami, Tsutomu Saji, Kenji Hamaoka, Hitoshi Kato, Hiroyuki Suzuki, Etsuko Tsuda, Mamoru Ayusawa, Masaru Miura, Ryota Ebata, Tomio Kobayashi, Mayumi Yashiro, Shunichi Ogawa
BACKGROUND: Giant coronary aneurysm is the most severe sequela in Kawasaki disease, occurring in approximately 0.2% of patients in Japan. Regression is rare, while myocardial infarction (MI) and sudden death are relatively common. Herein, we reviewed patients with giant coronary aneurysm in a 10-year period.Methods and Results:A nationwide questionnaire survey was conducted based on a national epidemiological database from 1999 to 2010. We identified 355 giant coronary aneurysm patients, of whom 209 were analyzed...
August 30, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28844482/impact-of-selective-serotonin-reuptake-inhibitors-on-neural-crest-stem-cell-formation
#14
Cecilia Vichier-Guerre, Margaret Parker, Yael Pomerantz, Richard H Finnell, Robert M Cabrera
The use of antidepressants in pregnant women is rising, with rates up to 7.5% in the United States. Selective serotonin reuptake inhibitors (SSRIs) are currently the most common antidepressant prescribed to pregnant women. The teratogenic effects of SSRI exposure are debated because of discrepancies in epidemiological studies. As an alternative to epidemiological and animal studies, human embryonic stem cell research (hESC) provides a human-based experimental model to examine the risks of prenatal SSRI exposure...
August 24, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28842438/plastics-and-cardiovascular-health-phthalates-may-disrupt-heart-rate-variability-and-cardiovascular-reactivity
#15
Rafael Jaimes, Adam Swiercz, Meredith Sherman, Narine Muselimyan, Paul Marvar, Nikki Gillum Posnack
BACKGROUND: Plastics have revolutionized medical device technology, transformed hematological care, and facilitated modern cardiology procedures. Despite these advances, studies have shown that phthalate chemicals migrate out of plastic products, and that these chemicals are bioactive. Recent epidemiological and research studies suggest that phthalate exposure adversely affects cardiovascular function. OBJECTIVE: To assess the safety and biocompatibility of phthalate chemicals, and resolve the impact on cardiovascular and autonomic physiology...
August 25, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28841590/cardiovascular-involvement-in-myositis
#16
Louise P Diederichsen
PURPOSE OF REVIEW: The purpose of this review is to provide an update on cardiovascular involvement in idiopathic inflammatory myopathy (IIM). Studies from the past 18 months are identified and reviewed. Finally, the clinical impact of these findings is discussed. RECENT FINDINGS: Epidemiological studies have revealed an increased risk of myocardial infraction and venous thromboembolism (VTE) - including deep venous thrombosis and pulmonary embolism - in adults with polymyositis or dermatomyositis compared to the general population, even after adjustment for potential confounders...
August 24, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28836039/fully-automated-left-ventricular-mass-and-volume-mri-analysis-in-the-uk-biobank-population-cohort-evaluation-of-initial-results
#17
Avan Suinesiaputra, Mihir M Sanghvi, Nay Aung, Jose Miguel Paiva, Filip Zemrak, Kenneth Fung, Elena Lukaschuk, Aaron M Lee, Valentina Carapella, Young Jin Kim, Jane Francis, Stefan K Piechnik, Stefan Neubauer, Andreas Greiser, Marie-Pierre Jolly, Carmel Hayes, Alistair A Young, Steffen E Petersen
UK Biobank, a large cohort study, plans to acquire 100,000 cardiac MRI studies by 2020. Although fully-automated left ventricular (LV) analysis was performed in the original acquisition, this was not designed for unsupervised incorporation into epidemiological studies. We sought to evaluate automated LV mass and volume (Siemens syngo InlineVF versions D13A and E11C), against manual analysis in a substantial sub-cohort of UK Biobank participants. Eight readers from two centers, trained to give consistent results, manually analyzed 4874 UK Biobank cases for LV end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF) and LV mass (LVM)...
August 23, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28835837/atrial-fibrillation-and-anticoagulation-in-hypertrophic-cardiomyopathy
#18
C Fielder Camm, A John Camm
Hypertrophic cardiomyopathy (HCM) represents a common inherited cardiac disorder with well-known complications Including stroke and sudden cardiac death. There is a recognised association between HCM and the development of AF. This review describes the epidemiology of AF within the HCM population and analyses the risk factors for the development of AF. It further discusses the outcomes associated with AF in this population, including the evidence in support of higher stroke risk in patients with HCM with AF compared with the general AF population...
June 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/28833665/predictors-of-smoking-relapse-after-percutaneous-coronary-intervention-in-chinese-patients
#19
Tingyu Zhang, Lizi Wang, Zhenzhen Xu, Qiongxiao Zhang, Yawen Ye
AIMS AND OBJECTIVES: The aim of this study was to evaluate the prevalence and predictors of smoking relapse after percutaneous coronary intervention (PCI) in Chinese patients. BACKGROUND: Smoking is considered a vital risk factor for coronary heart disease. Although smoking cessation could decrease the risks of adverse cardiac outcomes, many patients resume smoking following a short period of abstinence. However, little is known about smoking resumption in patients who have undergone PCI...
August 22, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28832795/cardiopulmonary-resuscitation-in-an-average-brazilian-intensive-care-unit-should-we-perform-less-or-better
#20
Leonardo Augusto Miana, Marcella Mendes Moraes, Bernardo Mendes Moraes, Pedro Guilherme Ponte, Eduardo Venturelli, Rodrigo Urbano Mallosto, Alexander Moreira-Almeida
Introduction: Few data can be found about cardiac arrest in the intensive care unit outside reference centers in third world countries. Objective: To study epidemiology and prognostic factors associated with cardiac arrest in the intensive care unit (ICU) in an average Brazilian center. Methods: Between June 2011 and July 2014, 302 cases of cardiac arrest in the intensive care unit were prospectively evaluated in 273 patients (age: 68.9 ± 15 years) admitted in three mixed units...
May 2017: Brazilian Journal of Cardiovascular Surgery
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