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Sex Steroids and depression

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https://www.readbyqxmd.com/read/27912889/hormone-replacement-therapy-in-young-women-with-primary-ovarian-insufficiency-and-early-menopause
#1
REVIEW
Shannon D Sullivan, Philip M Sarrel, Lawrence M Nelson
Primary ovarian insufficiency (POI) is a rare but important cause of ovarian hormone deficiency and infertility in women. In addition to causing infertility, POI is associated with multiple health risks, including bothersome menopausal symptoms, decreased bone density and increased risk of fractures, early progression of cardiovascular disease, psychologic impact that may include depression, anxiety, and decreased perceived psychosocial support, potential early decline in cognition, and dry eye syndrome. Appropriate hormone replacement therapy (HRT) to replace premenopausal levels of ovarian sex steroids is paramount to increasing quality of life for women with POI and ameliorating associated health risks...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27870443/sex-differences-in-depression-during-pregnancy-and-the-postpartum-period
#2
REVIEW
Inger Sundström Poromaa, Erika Comasco, Marios K Georgakis, Alkistis Skalkidou
Women have a lifetime risk of major depression double that of men but only during their reproductive years. This sex difference has been attributed partially to activational effects of female sex steroids and also to the burdens of pregnancy, childbirth, and parenting. Men, in contrast, have a reproductive period difficult to delineate, and research on the mental health of men has rarely considered the effects of fatherhood. However, the couple goes through a number of potentially stressing events during the reproductive period, and both mothers and fathers are at risk of developing peripartum depression...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27870419/sex-differences-in-brain-derived-neurotrophic-factor-signaling-and-functions
#3
REVIEW
Chi Bun Chan, Keqiang Ye
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family that plays a critical role in numerous neuronal activities. Recent studies have indicated that some functions or action mechanisms of BDNF vary in a sex-dependent manner. In particular, BDNF content in some brain parts and the tendency to develop BDNF deficiency-related diseases such as depression are greater in female animals. With the support of relevant studies, it has been suggested that sex hormones or steroids can modulate the activities of BDNF, which may account for its functional discrepancy in different sexes...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27858911/increased-risk-of-depression-in-patients-with-acquired-sensory-hearing-loss-a-12-year-follow-up-study
#4
Wei-Ting Hsu, Chih-Chao Hsu, Ming-Hsun Wen, Hong-Ching Lin, Hsun-Tien Tsai, Peijen Su, Chi-Te Sun, Cheng-Li Lin, Chung-Yi Hsu, Kuang-Hsi Chang, Yi-Chao Hsu
Acquired sensory hearing loss (SHL) is suggested to be associated with depression. However, some studies have reported conflicting results. Our study investigated the relationship between the prevalence of SHL and the incidence of depression over 12 years of follow-up by using data from the Taiwan National Health Insurance Research Database (NHIRD). We sought to determine the association between SHL and subsequent development of depression and discuss the pathophysiological mechanism underlying the association...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27817838/noncontraceptive-use-of-oral-combined-hormonal-contraceptives-in-polycystic-ovary-syndrome-risks-versus-benefits
#5
REVIEW
Anuja Dokras
The use of steroid sex hormones for noncontraceptive benefits has been endorsed by several medical societies. In women with polycystic ovary syndrome (PCOS), hormonal contraceptives are first-line therapy for concurrent treatment of menstrual irregularity, acne, and hirsutism. The association of PCOS with obesity, diabetes, and dyslipidemia frequently brings up the debate regarding risks versus benefits of hormonal contraceptives in this population. In women with PCOS, the lack of large-scale studies evaluating the risks with varying doses of ethinyl estradiol, types of progestins, and presence of confounding factors such as obesity, smoking, and other cardiometabolic comorbidities is a significant limitation in these deliberations...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27798296/thyroid-hormone-modulates-offspring-sex-ratio-in-a-turtle-with-temperature-dependent-sex-determination
#6
Bao-Jun Sun, Teng Li, Yi Mu, Jessica K McGlashan, Arthur Georges, Richard Shine, Wei-Guo Du
The adaptive significance of temperature-dependent sex determination (TSD) has attracted a great deal of research, but the underlying mechanisms by which temperature determines the sex of a developing embryo remain poorly understood. Here, we manipulated the level of a thyroid hormone (TH), triiodothyronine (T3), during embryonic development (by adding excess T3 to the eggs of the red-eared slider turtle Trachemys scripta, a reptile with TSD), to test two competing hypotheses on the proximate basis for TSD: the developmental rate hypothesis versus the hormone hypothesis Exogenous TH accelerated embryonic heart rate (and hence metabolic rate), developmental rate, and rates of early post-hatching growth...
October 26, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27589836/the-rate-of-change-in-declining-steroid-hormones-a-new-parameter-of-healthy-aging-in-men
#7
Andreas Walther, Michel Philipp, Niclà Lozza, Ulrike Ehlert
Research on healthy aging in men has increasingly focused on age-related hormonal changes. Testosterone (T) decline is primarily investigated, while age-related changes in other sex steroids (dehydroepiandrosterone [DHEA], estradiol [E2], progesterone [P]) are mostly neglected. An integrated hormone parameter reflecting aging processes in men has yet to be identified. 271 self-reporting healthy men between 40 and 75 provided both psychometric data and saliva samples for hormone analysis. Correlation analysis between age and sex steroids revealed negative associations for the four sex steroids (T, DHEA, E2, and P)...
August 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27513369/alteration-of-sex-hormone-levels-and-steroidogenic-pathway-by-several-low-molecular-weight-phthalates-and-their-metabolites-in-male-zebrafish-danio-rerio-and-or-human-adrenal-cell-h295r-line
#8
Juhae Sohn, Sujin Kim, Jan Koschorreck, Younglim Kho, Kyungho Choi
Low molecular weight phthalates, such as diethyl phthalate (DEP), benzyl butyl phthalate (BBzP), or diisobutyl phthalate (DiBP), are suspected to disrupt endocrine system. However, their adverse effects on sex steroid hormones and underlying mechanisms are not well-documented. The aim of this study is to investigate the effects of major low molecular weight phthalates (LMWPs), i.e., DEP, BBzP, and DiBP, and their hydrolytic metabolites, on sex steroid hormone system, employing male zebrafish and/or a human adrenocortical carcinoma (H295R) cell...
December 15, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27375045/sex-differences-in-the-effects-of-social-defeat-on-brain-and-behavior-in-the-california-mouse-insights-from-a-monogamous-rodent
#9
Michael Q Steinman, Brian C Trainor
Women are nearly twice as likely as men to be diagnosed with major depressive disorder, yet the use of female animal models in studying the biological basis of depression lags behind that of males. The social defeat model uses social stress to generate depression-like symptoms in order to study the neurobiological mechanisms. In general, social defeat is difficult to apply in female rodents. However, male and female California mice (Peromyscus californicus) are territorial. This allows defeat to be studied in both sexes...
June 30, 2016: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/27330158/most-patients-who-reach-disease-remission-following-anti-tnf-therapy-continue-to-report-fatigue-results-from-the-british-society-for-rheumatology-biologics-register-for-rheumatoid-arthritis
#10
Katie L Druce, Yagnaseni Bhattacharya, Gareth T Jones, Gary J Macfarlane, Neil Basu
OBJECTIVES: RA-related fatigue is common and debilitating, but does not always respond to immunotherapy. In the context of anti-TNF therapy, we aimed to examine whether patients achieving disease remission experienced remission of fatigue. METHODS: Data from the British Society for Rheumatology Biologics Register for RA were used. In participants with severe baseline fatigue [36-item Short Form Health Survey (SF-36) vitality score ⩽12.5], we identified those in disease remission [28-joint DAS (DAS28) <2...
October 2016: Rheumatology
https://www.readbyqxmd.com/read/27165125/sex-differences-in-the-serum-level-of-endogenous-ligands-for-estrogen-receptor-%C3%AE-in-the-elderly-population
#11
Miyuki Kobayashi, Nobuhiro Sugiyama, Daimei Sasayama, Hidehiko Sasamoto, Yoshimichi Miyashiro, Kunimasa Arima, Shinsuke Washizuka
Animal studies suggest that estrogen receptor β (ERβ)-agonists, but not ERα-agonists, are antidepressants. Several endogenous ligands for ERβ have been proposed, including 5α-androstane-3β, 17β-diol (3βAdiol), Androstenediol (Δ5-diol), and 7α-hydroxydehydroepiandrosterone (7α-OH-DHEA). The aim of this study was to determine the serum and salivary levels of natural ERβ ligands in men and women with and without past depressive episodes in the elderly population. DHEA (a precursor of 3βAdiol, Δ5-diol, and 7α-OH-DHEA), 17β-estradiol (E2), and cortisol (F) were also measured...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27100685/sex-steroids-and-major-psychoses-which-role-for-dhea-s-and-progesterone
#12
Massimiliano Buoli, Alice Caldiroli, Marta Serati, Silvia Grassi, A Carlo Altamura
OBJECTIVE: Endocrine pathways seem to play a role in the etiology of major psychoses. The identification of biomarkers associated with psychotic symptoms in schizophrenia (SKZ) and mood disorders would allow the identification of high-risk subjects for delusions and hallucinations. The aim of this study was to evaluate dehydroepiandrosterone sulfate (DHEA-S) and progesterone plasma levels in drug-free patients with major psychoses and their relation with the diagnosis and history of psychotic symptoms...
2016: Neuropsychobiology
https://www.readbyqxmd.com/read/26943343/sex-hormone-manipulation-slows-reaction-time-and-increases-labile-mood-in-healthy-women
#13
D S Stenbæk, P M Fisher, E Budtz-Jørgensen, A Pinborg, L V Hjordt, P S Jensen, G M Knudsen, V G Frokjaer
BACKGROUND: Women show increased risk of depressive symptoms in life phases where ovarian steroid hormone levels fluctuate or decline rapidly. The risk mechanisms may include changes in mental state and affective cognition possibly mediated by serotonergic neurotransmission. METHODS: In a randomized controlled double-blinded trial, 61 healthy women (mean age 24.3±4.9 years) were tested with measures of affective verbal memory, reaction time, mental distress, and serotonin transporter binding at baseline and at follow-up after receiving gonadotropin-releasing hormone agonist (GnRHa) or placebo intervention...
June 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/26912936/psychological-social-and-spiritual-effects-of-contraceptive-steroid-hormones
#14
Hanna Klaus, Manuel E Cortés
Governments and society have accepted and enthusiastically promoted contraception, especially contraceptive steroid hormones, as the means of assuring optimal timing and number of births, an undoubted health benefit, but they seldom advert to their limitations and side effects. This article reviews the literature on the psychological, social, and spiritual impact of contraceptive steroid use. While the widespread use of contraceptive steroid hormones has expanded life style and career choices for many women, their impact on the women's well-being, emotions, social relationships, and spirituality is seldom mentioned by advocates, and negative effects are often downplayed...
August 2015: Linacre Quarterly
https://www.readbyqxmd.com/read/26868968/sex-differences-in-the-outcome-of-juvenile-social-isolation-on-hpa-axis-function-in-rats
#15
M G Pisu, A Garau, G Boero, F Biggio, V Pibiri, R Dore, V Locci, E Paci, P Porcu, M Serra
Women are more likely than men to suffer from anxiety disorders and major depression. These disorders share hyperresponsiveness to stress as an etiological factor. Thus, sex differences in brain arousal systems and their regulation by chronic stress may account for the increased vulnerability to these disorders in women. Social isolation is a model of early life stress that results in neurobiological alterations leading to increased anxiety-like and depressive-like behaviors. Here we investigated the sex difference in the effects of post-weaning social isolation on acute stress sensitivity and behavior in rats...
April 21, 2016: Neuroscience
https://www.readbyqxmd.com/read/26652904/differential-effects-of-hormone-therapy-on-serotonin-vascular-function-and-mood-in-the-keeps
#16
RANDOMIZED CONTROLLED TRIAL
L Raz, L V Hunter, N M Dowling, W Wharton, C E Gleason, M Jayachandran, L Anderson, S Asthana, V M Miller
BACKGROUND: Serotonin (5-hydroxytryptamine, 5-HT) is modulated by sex steroid hormones and affects vascular function and mood. In the Kronos Early Estrogen Prevention Cognitive and Affective Ancillary Study (KEEPS-Cog), women randomized to oral conjugated equine estrogens (oCEE) showed greater benefit on affective mood states than women randomized to transdermal 17β-estradiol (tE2) or placebo (PL). This study examined the effect of these treatments on the platelet content of 5-HT as a surrogate measure of 5-HT synthesis and uptake in the brain...
2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/26624927/role-of-emotional-processing-in-depressive-responses-to-sex-hormone-manipulation-a-pharmacological-fmri-study
#17
RANDOMIZED CONTROLLED TRIAL
S Henningsson, K H Madsen, A Pinborg, M Heede, G M Knudsen, H R Siebner, V G Frokjaer
Sex-hormone fluctuations may increase risk for developing depressive symptoms and alter emotional processing as supported by observations in menopausal and pre- to postpartum transition. In this double-blinded, placebo-controlled study, we used blood-oxygen level dependent functional magnetic resonance imaging (fMRI) to investigate if sex-steroid hormone manipulation with a gonadotropin-releasing hormone agonist (GnRHa) influences emotional processing. Fifty-six healthy women were investigated twice: at baseline (follicular phase of menstrual cycle) and 16 ± 3 days post intervention...
2015: Translational Psychiatry
https://www.readbyqxmd.com/read/26483631/neo-synthesis-of-estrogenic-or-androgenic-neurosteroids-determine-whether-long-term-potentiation-or-depression-is-induced-in-hippocampus-of-male-rat
#18
Michela Di Mauro, Alessandro Tozzi, Paolo Calabresi, Vito Enrico Pettorossi, Silvarosa Grassi
Estrogenic and androgenic steroids synthesized in the brain may rapidly modulate synaptic plasticity interacting with specific membrane receptors. We explored by electrophysiological recordings in hippocampal slices of male rat the influence of 17β-estradiol (E2) and 5α-dihydrotestosterone (DHT) neo-synthesis on the synaptic changes induced in the CA1 region. Induction of long-term depression (LTD) and depotentiation (DP) by low frequency stimulation (LFS, 15 min-1 Hz) and of long-term potentiation (LTP) by high frequency stimulation (HFS, 1 s-100 Hz), medium (MFS, 1 s-50 Hz), or weak (WFS, 1 s-25 Hz) frequency stimulation was assayed under inhibitors of enzymes converting testosterone (T) into DHT (5α-reductase) and T into E2 (P450-aromatase)...
2015: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/26376217/sex-differences-in-cell-genesis-hippocampal-volume-and-behavioral-outcomes-in-a-rat-model-of-neonatal-hi
#19
Jaylyn Waddell, Marie Hanscom, N Shalon Edwards, Mary C McKenna, Margaret M McCarthy
Hypoxia-ischemia (HI) of the brain in near-term and term infants is a leading cause of infant mortality and lifelong disability but current therapeutic approaches remain limited. Males consistently display greater vulnerability to the deleterious consequences of HI in both humans and animal models. Neurogenesis increases after neonatal HI and offers a potential therapeutic target for recovery. The steroid hormone estradiol has been extensively explored as a neuroprotectant in adult models of stroke but with mixed results...
January 2016: Experimental Neurology
https://www.readbyqxmd.com/read/26372084/high-serum-testosterone-levels-during-postpartum-period-are-associated-with-postpartum-depression
#20
A Aswathi, Soundravally Rajendiren, Archana Nimesh, R Ravi Philip, Shivanand Kattimani, D Jayalakshmi, P H Ananthanarayanan, Pooja Dhiman
In view of the reported cases of mood disorders that occur in mothers following childbirth and believing that sex steroid hormones contribute to mood and behavioral changes, this study has been aimed to explore the role of sex steroid hormones as an etiological factor for postpartum depression (PPD). This study was conducted at JIPMER, Puducherry, India between January 2010 and 2011. 103 women were recruited in the study after childbirth, out of which 62 women who were believed to be suffering from PPD were categorized as cases and the remaining 41 with no mood changes as controls, using Edinburgh Postpartum Depression Scale (EPDS) (cases had EPDS score ≥10 at 24-28h, controls had score <10 at 24-48h postpartum)...
October 2015: Asian Journal of Psychiatry
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