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Sex Steroids and depression

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https://www.readbyqxmd.com/read/28609392/the-role-of-hormone-therapy-in-the-management-of-severe-postpartum-depression-in-patients-with-turner-syndrome
#1
Alison K Shea, Wendy Wolfman
OBJECTIVE: Premature ovarian failure associated with Turner syndrome presents clinicians with a vast range of health concerns, including infertility, cardiovascular disease, and decreased bone mineral density, in addition to psychological sequelae. Hormone therapy is paramount in managing these complications, but the additional needs in the postpartum period for those who are able to carry out a successful pregnancy have not been described. METHODS: We present a case of severe postpartum depression (PPD) with psychotic features in a patient with Turner syndrome, which presented at 4 weeks after the birth of her first child via egg donation RESULTS:: We describe the case of a previously well 32-year-old patient with an 46 X, i(Xq) karyotype, who went through a 4-week intensive inpatient treatment course for PPD, requiring electroconvulsant therapy for persistent infanticidal and suicidal ideation...
June 12, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28539995/the-effect-of-luteinizing-hormone-reducing-agent-on-anxiety-and-novel-object-recognition-memory-in-gonadectomized-rats
#2
Paria Arfa-Fatollahkhani, Arezo Nahavandi, Hossein Abtahi, Shabnam Anjidani, Sahar Borhani, Seyed Behnam Jameie, Mohammad Shabani, Saeed Mehrzadi, Ali Shahbazi
INTRODUCTION: Mood disorders such as anxiety and depression are common following menopause and andropause. Lack of sex steroid hormones is suggested as the primary cause of these disturbances. The level of luteinizing hormone (LH) would also rise 3-4 times than normal in these people. The potential effects of LH on mood and cognitive symptoms following menopause and andropause are still unknown. This study aimed to investigate the effect of increased LH on novel object discrimination (NOD) memory and anxiety like behavior in gonadectomized rats...
March 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28477436/brain-inflammasomes-in-stroke-and-depressive-disorders-regulation-by-estrogen
#3
REVIEW
Alexander Slowik, Leoni Lammerding, Stefanie Hoffmann, Cordian Beyer
Neuroinflammation is a devastating pathophysiological process which ends up in brain damage and neuronal death. Pathogens, cell fragments and cellular dysfunction trigger inflammatory responses. Irrespective of the cause, inflammasomes are key intracellular multiprotein signaling platforms which sense neuropathological conditions. The activation of inflammasomes leads to the auto-proteolytic cleavage of caspase-1, resulting in the proteolysis of the pro-inflammatory cytokines interleukin (IL)1beta and IL18 into their bioactive forms...
May 6, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28426945/testosterone-levels-in-healthy-men-correlate-negatively-with-serotonin-4-receptor-binding
#4
Erik Perfalk, Sofi da Cunha-Bang, Klaus K Holst, Sune Keller, Claus Svarer, Gitte M Knudsen, Vibe G Frokjaer
The serotonergic system integrates sex steroid information and plays a central role in mood and stress regulation, cognition, appetite and sleep. This interplay may be critical for likelihood of developing depressive episodes, at least in a subgroup of sensitive individuals. The serotonin 4 receptor (5-HT4R) indexes central serotonergic tonus, which may be related to endogenous sex-steroid levels in the mentally healthy state even though this remains elusive. Here we evaluate if peripheral levels of estradiol and testosterone are associated with 5-HT4R binding as imaged by [(11)C]SB207145 positron emission tomography in a group of 41 healthy men...
March 22, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28358594/psychiatric-symptoms-in-survivors-of-acute-respiratory-distress-syndrome-effects-of-age-sex-and-immune-modulation
#5
Joanna L Spencer-Segal, Robert C Hyzy, Theodore J Iwashyna, Theodore J Standiford
RATIONALE: Psychiatric morbidity after acute respiratory distress syndrome (ARDS) is common, and our current ability to predict psychiatric symptoms based on patient- and illness-specific factors is limited. OBJECTIVES: We assessed symptoms of anxiety, depression, and posttraumatic stress disorder (PTSD) in long-term survivors of ARDS, as well as the associated changes in cortisol levels. METHODS: The participants were enrolled in a randomized, double-blind, placebo-controlled trial of granulocyte macrophage-colony stimulating factor (GM-CSF) or placebo conducted at three academic medical centers...
June 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28215878/neuroactive-steroids-and-ptsd-treatment
#6
REVIEW
Ann M Rasmusson, Christine E Marx, Suzanne L Pineles, Andrea Locci, Erica R Scioli-Salter, Yael I Nillni, Jennifer J Liang, Graziano Pinna
This review highlights early efforts to translate pre-clinical and clinical findings regarding the role of neuroactive steroids in stress adaptation and PTSD into new therapeutics for PTSD. Numerous studies have demonstrated PTSD-related alterations in resting levels or the reactivity of neuroactive steroids and their targets. These studies also have demonstrated substantial variability in the dysfunction of specific neuroactive steroid systems among PTSD subpopulations. These variabilities have been related to the developmental timing of trauma, severity and type of trauma, genetic background, sex, reproductive state, lifestyle influences such as substance use and exercise, and the presence of comorbid conditions such as depression and chronic pain...
February 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28185934/corticosteroids-deeply-depress-the-in-vitro-steroidogenic-capacity-of-eurasian-perch-ovary-at-the-end-of-the-reproductive-cycle
#7
S N M Mandiki, S Milla, S Nkogo Robles, P Kestemont
Corticosteroids play positive or negative role in the reproductive mechanisms of many fish species but the physiological contexts relating to such biphasic actions are not well defined. In the present study we investigated to what extent corticosteroids (cortisol-Co, 11-deoxycorticosterone-DOC) hormones may interfere with the steroidogenic capacity of Eurasian perch ovarian tissues, and we tested whether the negative effects of corticosteroids may be mitigated by potential stimulating endocrine factors, namely insulin-like growth factor-1 (IGF), human chorionic gonadotropin (HCG) or thyroid hormones (Triidothyronine-T3, thyroxine-T4)...
February 7, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28132777/reduced-muscle-mass-in-middle-aged-depressed-patients-is-associated-with-male-gender-and-chronicity
#8
Kai G Kahl, Ferdi Utanir, Ulrich Schweiger, Tillmann H Krüger, Helge Frieling, Stefan Bleich, Marcel Gutberlet, Dagmar Hartung
OBJECTIVE: Reduced muscle mass is a characteristic finding in sarcopenia, the central element of physical frailty syndrome, and a major cause of physical function decay, morbidity and mortality in the elderly. Studies so far demonstrated reduced muscle mass in depressed patients with an average age over 60years. An open question is whether muscle mass reduction is already observed earlier. Therefore, muscle mass was assessed in middle-aged male and female depressive patients, and the findings were related to indicators of hypothalamus-pituitary adrenal axis activation, lifestyle factors, endocrine and immune measures...
January 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28038403/higher-serum-dhea-concentrations-before-and-after-ssri-treatment-are-associated-with-remission-of-major-depression
#9
Christina M Hough, Daniel Lindqvist, Elissa S Epel, Molly St Denis, Victor I Reus, F Saverio Bersani, Rebecca Rosser, Laura Mahan, Heather M Burke, Owen M Wolkowitz, Synthia H Mellon
BACKGROUND: Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-S), (together DHEA[S]), are the most abundant adrenal steroids in humans and are found in blood and the brain, where they function as neurosteroids with direct receptor affinities. Preclinical studies suggest that DHEA(S) has antidepressant/neuroprotective properties, and exogenously administered DHEA has shown antidepressant efficacy in humans. Nonetheless, the role of endogenous DHEA(S) levels in major depressive disorder (MDD) and antidepressant outcomes remains unclear...
March 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28030789/the-ssri-fluoxetine-exhibits-mild-effects-on-the-reproductive-axis-in-the-cichlid-fish-cichlasoma-dimerus-teleostei-cichliformes
#10
Luciana S Dorelle, Rodrigo H Da Cuña, Graciela Rey Vázquez, Christian Höcht, Akio Shimizu, Griselda Genovese, Fabiana L Lo Nostro
Among the wide variety of pharmaceuticals released into the environment, Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is one of the most prescribed for the treatment of major depression. It inhibits serotonin (5-HT) reuptake at the presinaptic membrane, increasing serotonergic activity. In vertebrates, including fish, the serotonergic system is closely related to the Hypothalamic Pituitary Gonadal (HPG) axis which regulates reproduction. As FLX can act as an endocrine disrupting compound (EDC) by affecting several reproductive parameters in fish, the aim of this study was to provide an integral assessment of the potential effect of FLX on the reproductive axis of the Neotropical freshwater fish Cichlasoma dimerus...
March 2017: Chemosphere
https://www.readbyqxmd.com/read/27912889/hormone-replacement-therapy-in-young-women-with-primary-ovarian-insufficiency-and-early-menopause
#11
REVIEW
Shannon D Sullivan, Philip M Sarrel, Lawrence M Nelson
Primary ovarian insufficiency (POI) is a rare but important cause of ovarian hormone deficiency and infertility in women. In addition to causing infertility, POI is associated with multiple health risks, including bothersome menopausal symptoms, decreased bone density and increased risk of fractures, early progression of cardiovascular disease, psychologic impact that may include depression, anxiety, and decreased perceived psychosocial support, potential early decline in cognition, and dry eye syndrome. Appropriate hormone replacement therapy (HRT) to replace premenopausal levels of ovarian sex steroids is paramount to increasing quality of life for women with POI and ameliorating associated health risks...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27870443/sex-differences-in-depression-during-pregnancy-and-the-postpartum-period
#12
REVIEW
Inger Sundström Poromaa, Erika Comasco, Marios K Georgakis, Alkistis Skalkidou
Women have a lifetime risk of major depression double that of men but only during their reproductive years. This sex difference has been attributed partially to activational effects of female sex steroids and also to the burdens of pregnancy, childbirth, and parenting. Men, in contrast, have a reproductive period difficult to delineate, and research on the mental health of men has rarely considered the effects of fatherhood. However, the couple goes through a number of potentially stressing events during the reproductive period, and both mothers and fathers are at risk of developing peripartum depression...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27870419/sex-differences-in-brain-derived-neurotrophic-factor-signaling-and-functions
#13
REVIEW
Chi Bun Chan, Keqiang Ye
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family that plays a critical role in numerous neuronal activities. Recent studies have indicated that some functions or action mechanisms of BDNF vary in a sex-dependent manner. In particular, BDNF content in some brain parts and the tendency to develop BDNF deficiency-related diseases such as depression are greater in female animals. With the support of relevant studies, it has been suggested that sex hormones or steroids can modulate the activities of BDNF, which may account for its functional discrepancy in different sexes...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27858911/increased-risk-of-depression-in-patients-with-acquired-sensory-hearing-loss-a-12-year-follow-up-study
#14
Wei-Ting Hsu, Chih-Chao Hsu, Ming-Hsun Wen, Hong-Ching Lin, Hsun-Tien Tsai, Peijen Su, Chi-Te Sun, Cheng-Li Lin, Chung-Yi Hsu, Kuang-Hsi Chang, Yi-Chao Hsu
Acquired sensory hearing loss (SHL) is suggested to be associated with depression. However, some studies have reported conflicting results. Our study investigated the relationship between the prevalence of SHL and the incidence of depression over 12 years of follow-up by using data from the Taiwan National Health Insurance Research Database (NHIRD). We sought to determine the association between SHL and subsequent development of depression and discuss the pathophysiological mechanism underlying the association...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27817838/noncontraceptive-use-of-oral-combined-hormonal-contraceptives-in-polycystic-ovary-syndrome-risks-versus-benefits
#15
REVIEW
Anuja Dokras
The use of steroid sex hormones for noncontraceptive benefits has been endorsed by several medical societies. In women with polycystic ovary syndrome (PCOS), hormonal contraceptives are first-line therapy for concurrent treatment of menstrual irregularity, acne, and hirsutism. The association of PCOS with obesity, diabetes, and dyslipidemia frequently brings up the debate regarding risks versus benefits of hormonal contraceptives in this population. In women with PCOS, the lack of large-scale studies evaluating the risks with varying doses of ethinyl estradiol, types of progestins, and presence of confounding factors such as obesity, smoking, and other cardiometabolic comorbidities is a significant limitation in these deliberations...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27798296/thyroid-hormone-modulates-offspring-sex-ratio-in-a-turtle-with-temperature-dependent-sex-determination
#16
Bao-Jun Sun, Teng Li, Yi Mu, Jessica K McGlashan, Arthur Georges, Richard Shine, Wei-Guo Du
The adaptive significance of temperature-dependent sex determination (TSD) has attracted a great deal of research, but the underlying mechanisms by which temperature determines the sex of a developing embryo remain poorly understood. Here, we manipulated the level of a thyroid hormone (TH), triiodothyronine (T3), during embryonic development (by adding excess T3 to the eggs of the red-eared slider turtle Trachemys scripta, a reptile with TSD), to test two competing hypotheses on the proximate basis for TSD: the developmental rate hypothesis versus the hormone hypothesis Exogenous TH accelerated embryonic heart rate (and hence metabolic rate), developmental rate, and rates of early post-hatching growth...
October 26, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27589836/the-rate-of-change-in-declining-steroid-hormones-a-new-parameter-of-healthy-aging-in-men
#17
Andreas Walther, Michel Philipp, Niclà Lozza, Ulrike Ehlert
Research on healthy aging in men has increasingly focused on age-related hormonal changes. Testosterone (T) decline is primarily investigated, while age-related changes in other sex steroids (dehydroepiandrosterone [DHEA], estradiol [E2], progesterone [P]) are mostly neglected. An integrated hormone parameter reflecting aging processes in men has yet to be identified. 271 self-reporting healthy men between 40 and 75 provided both psychometric data and saliva samples for hormone analysis. Correlation analysis between age and sex steroids revealed negative associations for the four sex steroids (T, DHEA, E2, and P)...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27513369/alteration-of-sex-hormone-levels-and-steroidogenic-pathway-by-several-low-molecular-weight-phthalates-and-their-metabolites-in-male-zebrafish-danio-rerio-and-or-human-adrenal-cell-h295r-line
#18
Juhae Sohn, Sujin Kim, Jan Koschorreck, Younglim Kho, Kyungho Choi
Low molecular weight phthalates, such as diethyl phthalate (DEP), benzyl butyl phthalate (BBzP), or diisobutyl phthalate (DiBP), are suspected to disrupt endocrine system. However, their adverse effects on sex steroid hormones and underlying mechanisms are not well-documented. The aim of this study is to investigate the effects of major low molecular weight phthalates (LMWPs), i.e., DEP, BBzP, and DiBP, and their hydrolytic metabolites, on sex steroid hormone system, employing male zebrafish and/or a human adrenocortical carcinoma (H295R) cell...
December 15, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27375045/sex-differences-in-the-effects-of-social-defeat-on-brain-and-behavior-in-the-california-mouse-insights-from-a-monogamous-rodent
#19
REVIEW
Michael Q Steinman, Brian C Trainor
Women are nearly twice as likely as men to be diagnosed with major depressive disorder, yet the use of female animal models in studying the biological basis of depression lags behind that of males. The social defeat model uses social stress to generate depression-like symptoms in order to study the neurobiological mechanisms. In general, social defeat is difficult to apply in female rodents. However, male and female California mice (Peromyscus californicus) are territorial. This allows defeat to be studied in both sexes...
January 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/27330158/most-patients-who-reach-disease-remission-following-anti-tnf-therapy-continue-to-report-fatigue-results-from-the-british-society-for-rheumatology-biologics-register-for-rheumatoid-arthritis
#20
Katie L Druce, Yagnaseni Bhattacharya, Gareth T Jones, Gary J Macfarlane, Neil Basu
OBJECTIVES: RA-related fatigue is common and debilitating, but does not always respond to immunotherapy. In the context of anti-TNF therapy, we aimed to examine whether patients achieving disease remission experienced remission of fatigue. METHODS: Data from the British Society for Rheumatology Biologics Register for RA were used. In participants with severe baseline fatigue [36-item Short Form Health Survey (SF-36) vitality score ⩽12.5], we identified those in disease remission [28-joint DAS (DAS28) <2...
October 2016: Rheumatology
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