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Sex differences and proteomics

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https://www.readbyqxmd.com/read/29288091/the-importance-of-accounting-for-sex-in-the-search-of-proteomic-signatures-of-mycotoxin-exposure
#1
L Soler, I P Oswald
Mycotoxins are natural food and feed contaminants that are toxic to human and animals. Proteomics is an adequate toolbox to investigate the mode of action and the effects of mycotoxins, as these toxicants often alter protein synthesis and degradation, as well as induce changes of important post-translational modifications. For instance, the contaminant deoxynivalenol induces a severe ribosomal stress that affects protein production, whereas the toxin Fumonisin B1 can alter the phosphorylation of a large number of proteins, and patulin is a potent proteotoxic molecule...
December 26, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29284736/carotid-atheroma-from-men-has-significantly-higher-levels-of-inflammation-and-iron-metabolism-enabled-by-macrophages
#2
Xi-Ming Yuan, Liam J Ward, Claes Forssell, Nabeel Siraj, Wei Li
BACKGROUND AND PURPOSE: Men differ from women in the manifestation of atherosclerosis and iron metabolism. Intraplaque hemorrhage and hemoglobin (Hb) catabolism by macrophages are associated with atherosclerotic lesion instability. The study aims were to investigate sex differences in (1) lesion severity in relation to blood Hb, (2) iron homeostasis in human carotid plaques, and (3) macrophage polarization within atheroma. METHODS: The carotid artery samples from 39 men and 23 women were immunostained with cell markers for macrophages, smooth muscle cells, ferritin, and TfR1 (transferrin receptor 1), which were further analyzed according to sex in relation to iron, Hb, and lipids in circulation...
December 28, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29277644/sex-differences-in-murine-myocardium-are-not-exclusively-regulated-by-gonadal-hormones
#3
Franz Theuring, Boris Neumann, Christian Scheler, Peter R Jungblut, Karima Schwab
We investigated sex differences in cardiac protein patterns of intact and castrated mice using proteomics and 1D and 2D immunoblotting. To exclude differences concerning developmental aspects gonadectomy was conducted in mature mice at the age of three months. The main sex-related regulation in the protein pattern of the myocardium occurred for proteins involved in metabolic processes whereas only few proteins involved in other pathways underwent a regulation. Many regulated proteins (2/3) displayed a characteristic V form, which means that these proteins are up- or down-regulated in sexually mature compared to young mice and are back-regulated after castration, emphasizing a direct regulation by gonadal hormones...
December 19, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29211968/men-and-women-differ-in-the-biochemical-composition-of-platelet-rich-plasma
#4
Grace Xiong, Nithya Lingampalli, Jayme C B Koltsov, Lawrence L Leung, Nidhi Bhutani, William H Robinson, Constance R Chu
BACKGROUND: Autologous platelet-rich plasma (PRP) is widely used for a variety of clinical applications. However, clinical outcome studies have not consistently shown positive effects. The composition of PRP differs based on many factors. An improved understanding of factors influencing the composition of PRP is important for the optimization of PRP use. HYPOTHESIS: Age and sex influence the PRP composition in healthy patients. STUDY DESIGN: Controlled laboratory study...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29202868/sp-a2-contributes-to-mirna-mediated-sex-differences-in-response-to-oxidative-stress-pro-inflammatory-anti-apoptotic-and-anti-oxidant-pathways-are-involved
#5
George T Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S Phelps, Todd M Umstead, Faryal Durrani, Joanna Floros
BACKGROUND: Human innate host defense molecules, surfactant protein A1 (SP-A1), and SP-A2 differentially affect the function and proteome of the alveolar macrophage (AM). We hypothesized that SP-A genes differentially regulate the AM miRNome. METHODS: Humanized transgenic mice expressing SP-A1 and SP-A2 were subjected to O3-induced oxidative stress (OxS) or filtered air (FA), AMs were isolated, and miRNA levels were measured. RESULTS: In SP-A2 males, we found significant changes in miRNome in terms of sex and sex-OxS effects, with 11 miRNAs differentially expressed under OxS...
December 4, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/29180046/proteomics-in-cardiovascular-diseases-unveiling-sex-and-gender-differences-in-the-era-of-precision-medicine
#6
Roberta Baetta, Marta Pontremoli, Alma Martinez Fernandez, Corinne M Spickett, Cristina Banfi
Cardiovascular diseases (CVDs) represent the most important cause of mortality in women and in men. Contrary to the long-standing notion that the effects of the major risk factors on CVD outcomes are the same in both sexes, recent evidence recognizes new, potentially independent, sex/gender-related risk factors for CVDs, and sex/gender-differences in the clinical presentation of CVDs have been demonstrated. Furthermore, some therapeutic options may not be equally effective and safe in men and women. In this context, proteomics offers an extremely useful and versatile analytical platform for biomedical researches that expand from the screening of early diagnostic and prognostic biomarkers to the investigation of the molecular mechanisms underlying CDVs...
November 24, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29175653/igm-antibodies-against-phosphorylcholine-promote-polarization-of-t-regulatory-cells-from-patients-with-atherosclerotic-plaques-systemic-lupus-erythematosus-and-healthy-donors
#7
Jitong Sun, Susanna L Lundström, Bo Zhang, Roman A Zubarev, Johnny Steuer, Peter Gillgren, Mizanur Rahman, Sofia Ajeganova, Anquan Liu, Johan Frostegård
BACKGROUND AND AIMS: IgM antibodies against phosphorylcholine (anti-PC) are negatively associated with atherosclerosis, cardiovascular disease (CVD) and systemic lupus erythematosus (SLE), where the risk of CVD and atherosclerosis is high. We here study the effects of IgM anti-PC immune regulation. METHODS: Mononuclear leukocytes were isolated from peripheral blood (PBMC) obtained from healthy blood donors, six SLE patients with age- and sex-matched controls, and symptom-giving human atherosclerotic plaques...
November 16, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29175092/differences-in-resistance-to-nitrogen-and-phosphorus-deficiencies-explain-male-biased-populations-of-poplar-in-nutrient-deficient-habitats
#8
Haifeng Song, Yanbao Lei, Sheng Zhang
In most forest soils, the availability of nitrogen (N) and phosphorus (P) nutrients is low and unable to meet the requirement of tree growth. In the past decades, sex-based differences in poplar have been investigated in morphology and physiology. Proteomic techniques provide new insights into sex-specific differences at the molecular level. This review gives a comparative overview of the effects of N and P deficiencies on poplar physiological and proteomic characteristics. Male poplars are more efficient at photosynthesis and nutrient usage than females...
November 21, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29148792/proteomic-markers-of-the-functional-sperm-population-in-bovines-1-comparison-of-low-and-high-density-spermatozoa-following-cryopreservation
#9
Olivier D'Amours, Gilles Frenette, Sylvie Bourassa, Ezequiel Calvo, Patrick Blondin, Robert Sullivan
Mammalian semen contains a heterogeneous population of sperm cells. This heterogeneity results from variability in the complex processes of cell differentiation in the testis, biochemical modifications undergone by spermatozoa during transit along the male reproductive tract, interactions with secretions from accessory sex glands at ejaculation, and, in the context of reproductive technologies, in the ability of ejaculated spermatozoa to resist damage associated with freeze-thaw procedures. When submitted to density gradient centrifugation, ejaculated spermatozoa distribute themselves into two distinct populations: a low-density population characterized by low motility parameters, and a high-density population with high motility characteristics...
November 17, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29130072/prediction-of-chronic-kidney-disease-stage-3-by-ckd273-a-urinary-proteomic-biomarker
#10
Claudia Pontillo, Zhen-Yu Zhang, Joost P Schanstra, Lotte Jacobs, Petra Zürbig, Lutgarde Thijs, Adela Ramírez-Torres, Hiddo J L Heerspink, Morten Lindhardt, Ronald Klein, Trevor Orchard, Massimo Porta, Rudolf W Bilous, Nishi Charturvedi, Peter Rossing, Antonia Vlahou, Eva Schepers, Griet Glorieux, William Mullen, Christian Delles, Peter Verhamme, Raymond Vanholder, Jan A Staessen, Harald Mischak, Joachim Jankowski
Introduction: CKD273 is a urinary biomarker, which in advanced chronic kidney disease predicts further deterioration. We investigated whether CKD273 can also predict a decline of estimated glomerular filtration rate (eGFR) to <60 ml/min per 1.73 m2. Methods: In analyses of 2087 individuals from 6 cohorts (46.4% women; 73.5% with diabetes; mean age, 46.1 years; eGFR ≥ 60 ml/min per 1.73 m2, 100%; urinary albumin excretion rate [UAE] ≥20 μg/min, 6.2%), we accounted for cohort, sex, age, mean arterial pressure, diabetes, and eGFR at baseline and expressed associations per 1-SD increment in urinary biomarkers...
November 2017: KI Reports
https://www.readbyqxmd.com/read/29123538/sex-specific-response-to-stress-in-populus
#11
REVIEW
Nataliya V Melnikova, Elena V Borkhert, Anastasiya V Snezhkina, Anna V Kudryavtseva, Alexey A Dmitriev
Populus is an effective model for genetic studies in trees. The genus Populus includes dioecious species, and the differences exhibited in males and females have been intensively studied. This review focused on the distinctions between male and female poplar and aspen plants under stress conditions, such as drought, salinity, heavy metals, and nutrient deficiency on morphological, physiological, proteome, and gene expression levels. In most studies, males of Populus species were more adaptive to the majority of the stress conditions and showed less damage, better growth, and higher photosynthetic capacity and antioxidant activity than that of the females...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29055862/juvenile-exposure-to-bisphenol-a-promotes-ovarian-differentiation-but-suppresses-its-growth-potential-involvement-of-pituitary-follicle-stimulating-hormone
#12
Weiting Chen, Shuk-Wa Lau, Yuqin Fan, Rudolf S S Wu, Wei Ge
Bisphenol A (BPA), a plastic monomer and plasticizer, is commonly used in plastics industry, and it has been well documented to be an estrogenic endocrine disrupter. In the present study, we investigated the effect of early (juvenile) exposure to BPA on the hypothalamic-pituitary-gonad (HPG) axis in the zebrafish. Estradiol (E2) and testosterone (T) were also included as positive and negative controls respectively. Juvenile zebrafish were exposed to BPA (1 and 10μM), E2 (10nM) and T (10nM) from 20 to 40 dpf (days post-fertilization), the period of sex/gonadal differentiation, followed by histological and expression analyses at 40 dpf...
December 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29037750/environmental-toxicology-and-omics-a-question-of-sex
#13
Xuefang Liang, April Feswick, Denina Simmons, Christopher J Martyniuk
Molecular initiating events and downstream transcriptional/proteomic responses provide valuable information for adverse outcome pathways, which can be used predict the effects of chemicals on physiological systems. There has been a paucity of research that addresses sex-specific expression profiling in toxicology and due to cost, time, and logistical considerations, sex as a variable has not been widely considered. In response to this deficiency, federal agencies in the United States, Canada, and Europe have highlighted the importance of including sex as a variable in scientific investigations...
October 13, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28993202/temporal-expression-profiling-of-plasma-proteins-reveals-oxidative-stress-in-early-stages-of-type-1-diabetes-progression
#14
Chih-Wei Liu, Lisa Bramer, Bobbie-Jo Webb-Robertson, Kathleen Waugh, Marian J Rewers, Qibin Zhang
Blood markers other than islet autoantibodies are greatly needed to indicate the pancreatic beta cell destruction process as early as possible, and more accurately reflect the progression of Type 1 Diabetes Mellitus (T1D). To this end, a longitudinal proteomic profiling of human plasma using TMT-10plex-based LC-MS/MS analysis was performed to track temporal proteomic changes of T1D patients (n=11) across 9 serial time points, spanning the period of T1D natural progression, in comparison with those of the matching healthy controls (n=10)...
October 7, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28988882/gender-proteomics-i-which-proteins-in-non-sexual-organs
#15
Elisabetta Gianazza, Ingrid Miller, Uliano Guerrini, Luca Palazzolo, Chiara Parravicini, Ivano Eberini
Differences related to gender have long been neglected but recent investigations show that they are widespread and may be recognized with all types of omics approaches, both in tissues and in biological fluids. Our review compiles evidence collected with proteomics techniques in our species, mainly focusing on baseline parameters in non-sexual organs in healthy men and women. Data from human specimens had to be replaced with information from other mammals every time invasive procedures of sample procurement were involved...
October 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28988880/gender-proteomics-ii-which-proteins-in-sexual-organs
#16
Elisabetta Gianazza, Ingrid Miller, Uliano Guerrini, Luca Palazzolo, Chiara Parravicini, Ivano Eberini
In continuity with the review dealing with differences by gender in non-sexual organs [1], this review collects data on the proteomes of the sexual organs as involved in human reproduction, under both physiological and pathological conditions. It also collects data on the tissue structures and biological fluids typical of pregnancy, such as placenta and amniotic fluid, as well as what may be tested on preimplantation embryos during medically assisted reproduction. The review includes as well mention to all fluids and secretions connected with sex organs and/or reproduction, including sperm and milk, to exemplify two distinctive items in male and female physiology...
October 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28974783/environmental-perturbation-of-the-circadian-clock-during-pregnancy-leads-to-transgenerational-mood-disorder-like-behaviors-in-mice
#17
Peng Zhang, Guang Li, Hui Li, XiaoQiu Tan, Hai-Ying Mary Cheng
It remains unknown whether chronic circadian disturbance (CCD) during pregnancy can lead to mood disorders in the offspring. Here we show that pregnant mice in the F0 generation that were exposed to CCD stress displayed depression-like behaviors, and produced offspring in the F1 and F2 generations that also exhibited mood-associated behavioral phenotypes despite the lack of direct stressful experiences during their postnatal or adult period. Prenatal CCD stress was correlated with the elevation of plasma corticosterone levels in F1 mice...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28961403/the-z-chromosome-is-enriched-for-sperm-proteins-in-two-divergent-species-of-lepidoptera
#18
Andrew J Mongue, James Walters
Genes that promote sexual conflict, such as those with a sex-limited fitness benefit, are expected to accumulate differentially on sex chromosomes relative to autosomes. Few tests of this hypothesis exist for male homogametic (ZZ) taxa, however, and most use RNA expression data to identify such genes. Here, we employ a different identification method by using proteomic analysis of sperm cells to identify genes with a sex-limited benefit. We tested for a bias in genomic location of sperm protein genes in two species of Lepidoptera...
September 29, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28950061/sexual-dimorphism-age-and-fat-mass-are-key-phenotypic-drivers-of-proteomic-signatures
#19
Aoife M Curran, Colleen Fogarty Draper, Marie-Pier Scott-Boyer, Armand Valsesia, Helen M Roche, Miriam F Ryan, Michael J Gibney, Martina Kutmon, Chris T Evelo, Susan L Coort, Arne Astrup, Wim H Saris, Lorraine Brennan, Jim Kaput
Validated protein biomarkers are needed for assessing health trajectories, predicting and subclassifying disease, and optimizing diagnostic and therapeutic clinical decision-making. The sensitivity, specificity, accuracy, and precision of single or combinations of protein biomarkers may be altered by differences in physiological states limiting the ability to translate research results to clinically useful diagnostic tests. Aptamer based affinity assays were used to test whether low abundant serum proteins differed based on age, sex, and fat mass in a healthy population of 94 males and 102 females from the MECHE cohort...
October 4, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28935211/sustained-molecular-pathology-across-episodes-and-remission-in-major-depressive-disorder
#20
Enzo Scifo, Mohan Pabba, Fenika Kapadia, Tianzhou Ma, David A Lewis, George C Tseng, Etienne Sibille
BACKGROUND: Major depressive disorder (MDD) is a debilitating mental illness and a major cause of lost productivity worldwide. MDD patients often suffer from life-long recurring episodes of increasing severity, reduced therapeutic response, and shorter remission periods, suggesting the presence of a persistent and potentially progressive pathology. METHODS: Subgenual anterior cingulate cortex postmortem samples from four MDD cohorts (single episode, n = 20; single episode in remission, n = 15; recurrent episode, n = 20; and recurrent episode in remission, n = 15), and one control cohort (n = 20) were analyzed by mass spectrometry-based proteomics (n = 3630 proteins) combined with statistical analyses...
August 18, 2017: Biological Psychiatry
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