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https://www.readbyqxmd.com/read/29143139/effect-of-protein-adsorption-layers-and-solution-treatments-on-hydroxyapatite-deposition-on-polystyrene-plate-surfaces-in-simulated-body-fluids
#1
Kazutoshi Iijima, Ayako Iizuka, Ryo Suzuki, Hitomi Ueno-Yokohata, Nobutaka Kiyokawa, Mineo Hashizume
We have developed a method to functionalize polystyrene (PS) cell culture plates with hydroxyapatite (HAp) via protein adsorption layers such as human serum albumin (HSA) in simulated body fluids (SBFs). In order to investigate the versatility the method, in this study the effect of protein adsorption layers on HAp deposition on PS plate surfaces in SBF was evaluated. Pretreatments with alternate soaking process (ASP) using solutions containing calcium ions and phosphate ions followed by incubation with SBF for 24 h resulted in HAp deposition on PS plates with adsorption layers of HSA, type I collagen, hen egg white lysozyme, and poly L-glutamic acid, an acidic protein analogue: the deposition behaviors were correlated with adsorption ability and charge state of proteins...
November 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29142988/proximal-tubular-expression-patterns-of-megalin-and-cubilin-in-proteinuric-nephropathies
#2
Jia Sun, Kjell Hultenby, Jonas Axelsson, Johan Nordström, Bing He, Annika Wernerson, Karin Lindström
Introduction: Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal tubules. For albumin this process involves at least 2 interacting receptors, megalin and cubilin. Albumin is not usually present in the urine, indicating a highly efficient tubular reuptake under physiological conditions. However, early appearance of albuminuria may mean that the tubular system is overwhelmed by large quantities of albumin or that the function is impaired. Methods: To better understand the physiological role of megalin and cubilin in human renal disease, renal biopsies from 15 patients with a range of albuminuria and 3 healthy living donors were analyzed for proximal tubular expression of megalin and cubilin using immunohistochemistry (IHC) and semiquantitative immune-electron microscopy...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29142170/characterization-of-a-rat-model-of-moderate-liver-dysfunction-based-on-alpha-naphthylisothiocyanate-induced-cholestasis
#3
Melanie K Bothe, Christoph Meyer, Udo Mueller, Jean-Christophe Queudot, Virginie Roger, Johannes Harleman, Martin Westphal
Plasma amino acid level changes occur in mild, moderate and severe stages of liver injury in human patients. In animal models, however, data are mainly restricted to severe liver injury models in rats. Here we present the characterization of a rat model of moderate liver dysfunction secondary to alpha-napthylisothiocyanate (ANIT)-induced cholestasis. Rats treated with 30 mg/kg/day ANIT for 3 weeks exhibited a time-dependent increase in plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and bilirubin levels and a decrease in albumin concentration...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29141752/differences-in-nutritional-and-health-status-in-school-children-from-the-highlands-and-lowlands-of-bolivia
#4
Graciela Terán, Washington Cuna, Froilán Brañez, Kristina E M Persson, Martín E Rottenberg, Susanne Nylén, Celeste Rodriguez
Children in the Bolivian Andes are exposed to endemic infections and meager nourishment, and live under poor hygienic conditions. The prevention of children malnutrition is a priority in many countries including Bolivia. In this study, the health status of schoolchildren in Taraco, a Puna district, at 4,000 meters above sea level (masl) and in Caranavi, at 650 masl in the wealthier subtropical valleys, was compared. The weight, height, and hematological and biochemical parameters in blood, parasites in stool, and clinical information in 120 children from rural Taraco and in 96 from semi-urban Caranavi, both predominantly of Aymara ethnicity, were registered...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140985/notch-signaling-and-progenitor-ductular-reaction-in-steatohepatitis
#5
Carola M Morell, Romina Fiorotto, Marica Meroni, Aileen Raizner, Barbara Torsello, Massimiliano Cadamuro, Gaia Spagnuolo, Eleanna Kaffe, Salvatore Sutti, Emanuele Albano, Mario Strazzabosco
BACKGROUND AND OBJECTIVE: Persistent hepatic progenitor cells (HPC) activation resulting in ductular reaction (DR) is responsible for pathologic liver repair in cholangiopathies. Also, HPC/DR expansion correlates with fibrosis in several chronic liver diseases, including steatohepatitis. Increasing evidence indicates Notch signaling as a key regulator of HPC/DR response in biliary and more in general liver injuries. Therefore, we aimed to investigate the role of Notch during HPC/DR activation in a mouse model of steatohepatitis...
2017: PloS One
https://www.readbyqxmd.com/read/29139376/the-longitudinal-effects-of-peritonitis-on-peritoneal-membrane-function%C3%A2
#6
Christopher S B Sia, Eldho Paul, Peter Tregaskis, Rowan G Walker, Scott G Wilson
BACKGROUND: The longitudinal effects of peritoneal dialysis (PD) peritonitis on small solute clearance and ultrafiltration are controversial. MATERIALS AND METHODS: We identified 27 patients with PD peritonitis over a 4-year period at a tertiary hospital. Adequacy tests at an "early" (1 - 3 months), "intermediate" (6 ± 2 months), and a "late" (12 ± 2 months) time period after the episode were compared with a pre-peritonitis baseline. The effect of time on serum albumin, weekly creatinine clearance, Kt/V, and net fluid volume removal was assessed...
December 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29138578/prognostic-value-of-the-c-reactive-protein-to-albumin-ratio-a-novel-inflammation-based-prognostic-indicator-in-osteosarcoma
#7
Yong-Jiang Li, Kai Yao, Min-Xun Lu, Wen-Biao Zhang, Cong Xiao, Chong-Qi Tu
The prognostic role of the C-reactive protein to albumin ratio (CRP/Alb ratio) in patients with osteosarcoma has not been investigated. A total of 216 osteosarcoma patients were enrolled in the study. Univariate and multivariate survival analyses between the groups were performed and Kaplan-Meier analysis was conducted to plot the survival curves. Receiver operating characteristic curves were generated and areas under the curve (AUCs) were compared to assess the discriminatory ability of the inflammation-based indicators, including CRP/Alb ratio, Glasgow prognostic score (GPS), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29137984/recombinant-human-glp-1-rhglp-1-alleviating-renal-tubulointestitial-injury-in-diabetic-stz-induced-rats
#8
Weiqin Yin, Shiqing Xu, Zai Wang, Honglin Liu, Liang Peng, Qing Fang, Tingting Deng, Wenjian Zhang, Jinning Lou
GLP-1-based treatment improves glycemia through stimulation of insulin secretion and inhibition of glucagon secretion. Recently, more and more findings showed that GLP-1 could also protect kidney from diabetic nephropathy. Most of these studies focused on glomeruli, but the effect of GLP-1 on tubulointerstitial and tubule is not clear yet. In this study, we examined the renoprotective effect of recombinant human GLP-1 (rhGLP-1), and investigated the influence of GLP-1 on inflammation and tubulointerstitial injury using diabetic nephropathy rats model of STZ-induced...
November 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29137802/nanocomposite-materials-based-on-poly-vinyl-chloride-and-bovine-serum-albumin-modified-zno-through-ultrasonic-irradiation-as-a-green-technique-optical-thermal-mechanical-and-morphological-properties
#9
Shadpour Mallakpour, Marzieh Darvishzadeh
In this project, physicochemical properties of poly(vinyl chloride) (PVC) reinforced by ZnO nanoparticles (NPs) were studied. Firstly, ZnO NPs were modified with bovine serum albumin (BSA) as an organo-modifier and biocompatible substance through ultrasound irradiation as environmental friendly, low cost and rapid means. Nanocomposite (NC) films were prepared by loadings of various ratios of ZnO/BSA NPs (3, 6 and 9wt%) inside the PVC. Structural morphology and physical properties of the ZnO-BSA NPs and NC films were investigated via Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis (TGA), transmission electron microscopy and field emission scanning electron microscopy...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137761/ultrasound-assisted-surface-treatment-of-zro2-with-bsa-and-incorporating-in-pvc-to-improve-the-properties-of-the-obtained-nanocomposites-fabrication-and-characterization
#10
Shadpour Mallakpour, Zahra Hajjari
This paper describes the preparation of poly(vinyl chloride) (PVC) nanocomposites (NCs) reinforced with modified zirconia (ZrO2) nanoparticles (NPs). The ZrO2 NPs were defined as efficient filler for PVC NCs. For achieving the best dispersion and improvement of properties, the surface of ZrO2 NPs was modified by Bovine Serum Albumin (BSA). Carboxylic acids and amines are important functional groups of BSA which handle the grafting BSA on the surface of ZrO2 NPs. The PVC/ZrO2-BSA NCs were fabricated by incorporation of various amounts of the ZrO2-BSA NPs (3, 6 and 9wt%) into PVC matrix...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137730/the-influence-of-bovine-serum-albumin-modified-silica-on-the-physicochemical-properties-of-poly-vinyl-alcohol-nanocomposites-synthesized-by-ultrasonication-technique
#11
Shadpour Mallakpour, Hossein Yazdan Nazari
In this study, for the first time polymeric nanocomposite (NC) films of poly(vinyl alcohol)/SiO2@bovine serum albumin (PVA/SiO2@BSA) were synthesized by solution casting method under facile and fast method of sonication. In this regard, SiO2 nanoparticles (NPs) were modified by BSA, at room temperature by using phosphate buffer and ultrasonic-assisted method. Then, PVA/SiO2@BSA NCs were prepared by insertion of variant amount (3, 6 and 9wt%) of SiO2@BSA into the PVA matrix, under ultrasonic irradiation. The morphological traits of the NCs were surveyed by Fourier transform infrared spectroscopy, transmission electron microscopy, X-ray diffraction and field emission scanning electron microscopy...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137377/an-evaluation-of-nutrition-intervention-during-radiation-therapy-in-patients-with-locoregionally-advanced-nasopharyngeal-carcinoma
#12
Ting Jin, Kai-Xin Li, Pei-Jing Li, Shuang Huang, Xiao-Zhong Chen, Ming Chen, Qiao-Ying Hu, Lei Shi, Yuan-Yuan Chen
Purpose: To evaluate the effectiveness of nutrition intervention during radiation for patients with locoregionally advanced (III-IVa) nasopharyngeal carcinoma (NPC). Materials and Methods: We retrospectively reviewed 117 patients with locoregionally advanced (III-IVa) NPC treated between December 2015 and March 2016 in Zhejiang Cancer Hospital. All the patients underwent radical chemo-radiotherapy. First, all the patients were divided into the nutrition intervention group and the control group, depending on whether they accepted nutrition intervention...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136892/green-synthesis-of-monolithic-column-incorporated-with-graphene-oxide-using-room-temperature-ionic-liquid-and-eutectic-solvents-for-capillary-electrochromatography
#13
Xin-Xin Li, Li-Shun Zhang, Chao Wang, Yan-Ping Huang, Zhao-Sheng Liu
In this work, a hybrid monolith incorporated with graphene oxide (GO) was prepared in the first time with binary green porogens of deep eutectic solvents (DESs) and room temperature ionic liquids (RTILs). GO was modified with 3-(trimethoxysilyl) propylmethacrylate (γ-MPS), and the resultant GO-MPS can be incorporated into poly (methacrylic acid-co-butylmethacrylate-co-ethylene glycol dimethacrylate) monoliths covalently. A hybrid monolithic column with high permeability and homogeneity can be achieved due to good dispersion of GO-MPS in the green solvents...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136782/effect-of-human-umbilical-cord-blood-derived-mononuclear-cells-on-diabetic-nephropathy-in-rats
#14
Nahla E El-Ashmawy, Eman G Khedr, Hoda A El-Bahrawy, Shimaa A El-Berashy
Diabetic nephropathy (DN) is damage to the kidney which can lead to chronic renal failure, eventually requiring dialysis. Diabetes mellitus is the most common cause of adult kidney failure worldwide in the developed world. The current work was designed to elucidate the effect of mononuclear cells (MNCs) injection on reverse DN in rats exposed to streptozotocin (STZ) injection compared to metformin as a known hypoglycemic drug, 40 Male rats were divided equally into 4 groups; normal control group, diabetic control group, MNCs group were diabetic rats treated with MNCs (30×10(6) MNCs/rat once iv dose) in the tail vein of the rat, and metformin group were diabetic rats treated with metformin (100mg/kg orally daily dose) for four weeks...
November 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29134253/the-role-of-the-neutrophil-lymphocyte-ratio-nlr-and-the-crp-albumin-ratio-car-in-predicting-mortality-following-emergency-laparotomy-in-the-over-80-age-group
#15
G Simpson, R Saunders, J Wilson, C Magee
INTRODUCTION: Emergency laparotomy in the elderly is an increasingly common procedure which carries high morbidity and mortality. Risk prediction tools, although imperfect, can help guide management decisions. Novel markers of surgical outcomes may contribute to these scoring systems. The neutrophil:lymphocyte ratio (NLR) and CRP:albumin ratio (CAR) have been associated with outcomes in malignancy and sepsis. We assessed the use of ratio NLR and CAR as prognostic indicators in patients over the age of 80 undergoing emergency laparotomy...
November 13, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29133078/enteric-delivery-of-regenerating-family-member-3-alpha-alters-the-intestinal-microbiota-and-controls-inflammation-in-mice-with-colitis
#16
Marion Darnaud, Alexandre Dos Santos, Patrick Gonzalez, Sandrine Augui, Claire Lacoste, Christophe Desterke, Gert De Hertogh, Emma Valentino, Emilie Braun, Jinzi Zheng, Raphael Boisgard, Christel Neut, Laurent Dubuquoy, Franck Chiappini, Didier Samuel, Patricia Lepage, Francesca Guerrieri, Joel Doré, Christian Bréchot, Nicolas Moniaux, Jamila Faivre
BACKGROUND & AIMS: Paneth cell dysfunction causes deficiencies in intestinal C-type lectins and antimicrobial peptides, which leads to dysbiosis of the intestinal microbiota, alters the mucosal barrier, and promotes development of inflammatory bowel diseases. We investigated whether transgenic expression of the human regenerating family member 3 alpha gene (REG3A) alters the fecal microbiota and affects development of colitis in mice. METHODS: We performed studies with C57BL/6 mice that express human regenerating family member 3 alpha (hREG3A) in hepatocytes, via the albumin gene promoter...
November 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29132905/purification-and-biochemical-characterization-of-a-22-kda-stable-cysteine-like-protease-from-the-excretory-secretory-product-of-the-liver-fluke-fasciola-hepatica-by-using-conventional-techniques
#17
Ahmed Hemici, Roumaila Sabrina Benerbaiha, Dalila Bendjeddou
This study describes the purification and characterization of a stable protease activity isolated from Fasciola hepatica adult worms maintained in vitro by employing acetone precipitation (40-60%) followed by a gel filtration through Sephadex G-100 and DEAE- cellulose ion exchange column. Through this three-step purification, the enzyme was purified 11-fold with a specific activity of 1893.9U/mg and 31.5% recovery. After the final ultrafiltration step, the purification fold was increased up to 13.1 and the overall activity yield reached a rate of 18...
October 28, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29132543/intravenous-administration-of-functionalized-magnetic-iron-oxide-nanoparticles-does-not-induce-cns-injury-in-the-rat-influence-of-spinal-cord-trauma-and-cerebrolysin-treatment
#18
Preeti K Menon, Aruna Sharma, José V Lafuente, Dafin F Muresanu, Zoraida P Aguilar, Y Anderw Wang, Ranjana Patnaik, Herbert Mössler, Hari S Sharma
Influence of iron oxide magnetic nanoparticles (IOMNPs, 10nm in diameter, 0.25 or 0.50mg/mL in 100μL, i.v.) on the blood-brain barrier (BBB) permeability, edema formation, and neuronal or glial changes within 4-24h after administration was examined in normal rats and after a focal spinal cord injury (SCI). Furthermore, effect of cerebrolysin, a balanced composition of several neurotrophic factors, and active peptide fragments was also evaluated on IOMNP-induced changes in central nervous system (CNS) pathology...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29131287/the-relationship-between-ischemia-modified-albumin-and-good-coronary-collateral-circulation
#19
Murat Gök, Harun Kundi, Emrullah Kızıltunç, Canan Topcuoglu, Ender Örnek
BACKGROUND: It is important to determine the grade of the coronary collateral circulation (CCC) in patients with stable coronary artery disease (CAD). AIM: In this study, we aimed to investigate the relationship between the ischemia modified albumin (IMA) level and good CCC. METHODS: A total of 95 patients with coronary angiography and at least one epicardial coronary artery obstruction were included in the study. The Rentrop classification was used with CCC grading, where 0 and 1 were defined as poor collateral, and 2 and 3 were defined as good collateral...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29130148/interaction-of-zearalenone-with-bovine-serum-albumin-as-determined-by-fluorescence-quenching
#20
Liang Ma, Chris M Maragos, Yuhao Zhang
The major aim of this study was to examine the binding of zearalenone (ZEN) to bovine serum albumin (BSA) by measuring the quenching of the intrinsic fluorescence of the protein under aqueous conditions. The results suggest that ZEN has a strong ability to quench the intrinsic fluorescence of BSA through a static mechanism. The hydrophobicity of the microenvironment around the tyrosine (Tyr) residues in BSA was increased in the presence of ZEN. The quenching constants, ratio of protein with ZEN, and thermodynamic parameters were determined...
November 13, 2017: Mycotoxin Research
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