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https://www.readbyqxmd.com/read/28820982/direct-analysis-no-sample-preparation-of-bioavailable-cortisol-in-human-plasma-by-weak-affinity-chromatography-wac
#1
Sten Ohlson, Jagjit Kaur, Manfred Raida, Ulf Niss, Tim Bengala, Chester Lee Drum, Bernhard Boehm, Anthony R Torres
Pre-analytical treatment of blood plasma is a time consuming and often rate limiting step in the workflow of LC/MS analysis. We present in this pilot study a new approach for quantitative LC/MS based on weak affinity chromatography (WAC) of crude plasma. The steroid hormone cortisol was selected as a clinically relevant biomarker, as it currently requires extensive pre-analytical preparation. A WAC unit with saturating, immobilized albumin as a prototypic weak binder was used in combination with an ion-funnel MS/MS detector to perform zonal affinity chromatography of cortisol directly from a plasma sample, followed by quantitative multiple reaction monitoring (MRM)...
July 21, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28820885/diagnostic-efficacy-of-noninvasive-liver-fibrosis-indexes-in-predicting-portal-hypertension-in-patients-with-cirrhosis
#2
Le Wang, Yuemin Feng, Xiaowen Ma, Guangchuan Wang, Hao Wu, Xiaoyu Xie, Chunqing Zhang, Qiang Zhu
BACKGROUND: Recent data suggest that noninvasive liver fibrosis indexes could be useful for predicting esophageal varices (EV) in cirrhotic patients. However, thus far, the diagnostic efficacy of these indexes in predicting portal hypertension (PH) in cirrhotic patients has been poorly evaluated. AIMS: To evaluate the diagnostic efficacy of noninvasive liver fibrosis indexes in the diagnosis of PH. METHODS: A total of 238 cirrhotic patients underwent hepatic venous pressure gradient (HVPG) evaluation and relevant serum tests to analyze the variables associated with PH grade...
2017: PloS One
https://www.readbyqxmd.com/read/28819987/maximum-home-blood-pressure-is-a-useful-indicator-of-diabetic-nephropathy-in-patients-with-type-2-diabetes-mellitus-kamogawa-hbp-study
#3
Chikako Oyabu, Emi Ushigome, Shinobu Matsumoto, Toru Tanaka, Goji Hasegawa, Naoto Nakamura, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Isao Yokota, Muhei Tanaka, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
OBJECTIVE: Maximum home systolic blood pressure has been shown to predict target organ damage. We aimed to clarify the association between maximum home systolic blood pressure and urine albumin to creatinine ratio, an indicator of early-phase diabetic nephropathy in patients with type 2 diabetes. METHODS: In 1040 patients, we assessed the relationship of mean or maximum home systolic blood pressure and urine albumin to creatinine ratio, and compared the area under the receiver operating characteristic curve of mean or maximum home systolic blood pressure for diabetic nephropathy (urine albumin to creatinine ratio ⩾30 mg/g Cr)...
August 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28819780/preliminary-research-on-syndrome-types-of-chinese-medicine-in-children-with-primary-nephrotic-syndrome
#4
Wen Sun, Jian Yu, Gu-Lan Zeng, Bing-Feng Zhang
OBJECTIVE: To provide an objective reference for the syndrome types of Chinese medicine (CM) associated with pediatric primary nephrotic syndrome (PNS). METHODS: A cross-sectional study was performed. Data on clinical symptoms, CM syndrome types, biochemical indices, and medications used were collected from 98 children with PNS. Then, the correlation between CM syndromes and biochemical indices, as well as medications used, was analyzed. RESULTS: The four most common symptoms in children with PNS were brown urine, red tongue, excessive sweating, and swelling of the face and limbs...
August 17, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28818597/is-there-a-j-shaped-relationship-between-the-fatty-liver-index-and-risk-of-microalbuminuria-in-the-general-population
#5
Jong Wook Choi, Il Hwan Oh, Chang Hwa Lee, Joon-Sung Park
BACKGROUND: We investigated whether the fatty liver index (FLI), as a clinical indicator of hepatic fat accumulation based on body mass index, gamma-glutamyl-transferase, triglycerides, and waist circumference, has an association with microalbuminuria. METHODS: We analyzed anthropometric and biochemical data from a nation-wide, population-based, cross-sectional study. A total of 1605 participants included were healthy native Korean 40years or older and divided into quintiles according to their log-FLI and sex...
August 14, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28817994/maternal-serum-and-fetal-cord-blood-ischemia-modified-albumin-concentrations-in-normal-pregnancy-and-preeclampsia-a-systematic-review-and-meta-analysis
#6
Varikasuvu Seshadri Reddy, Pragathi Duggina, Mrudula Vedhantam, Munikumar Manne, Neelakant Varma, Nagaram Srinivas
BACKGROUND/AIMS: A meta-analysis of maternal serum ischemia-modified albumin (IMA) and fetal cord blood IMA concentrations in normal pregnancy (NP) compared to nonpregnant healthy controls (HC) and in preeclampsia (PE) compared to normal pregnant controls were studied. METHODS: All major databases were searched for eligible studies. We included 8 studies comparing serum IMA between NP and HC, 14 studies comparing serum IMA between PE and NP and 5 studies comparing cord-blood IMA between PE and NP groups...
August 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28817685/clinical-implications-of-carcinoembryonic-antigen-distribution-in-serum-exosomal-fraction-measurement-by-elisa
#7
Shozo Yokoyama, Akihiro Takeuchi, Shunsuke Yamaguchi, Yasuyuki Mitani, Takashi Watanabe, Kenji Matsuda, Tsukasa Hotta, John E Shively, Hiroki Yamaue
BACKGROUND: Serum exosomal proteins have great potential as indicators of disease status in cancer, inflammatory or metabolic diseases. The association of a fraction of various serum proteins such as carcinoembryonic antigen (CEA) with circulating exosomes has been debated. The establishment of a method to measure the exosomal fraction of such proteins might help resolve this controversy. The use of enzyme-linked immunosorbent assays (ELISAs) to measure serum exosomal molecules, for example CEA, is rare in research laboratories and totally absent in clinical biology...
2017: PloS One
https://www.readbyqxmd.com/read/28816920/similar-metabolic-innate-immunity-and-adipokine-profiles-in-adult-and-pediatric-sepsis-versus-systemic-inflammatory-response-syndrome-a-pilot-study
#8
Theonymfi Tavladaki, Anna Maria Spanaki, Helen Dimitriou, Efmorfia Kondili, Christianna Choulaki, Dimitris Georgopoulos, George Briassoulis
OBJECTIVES: To examine whether the septic profiles of heat shock protein 72, heat shock protein 90α, resistin, adiponectin, oxygen consumption, CO2 production, energy expenditure, and metabolic pattern, along with illness severity, nutritional, and inflammatory indices, differ between adult and pediatric patients compared with systemic inflammatory response syndrome and healthy controls. To evaluate whether these biomolecules may discriminate sepsis from systemic inflammatory response syndrome in adult and pediatric patients...
August 12, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28816534/seven-familial-dysalbuminemic-hyperthyroxinemia-cases-in-three-unrelated-japanese-families-and-high-performance-liquid-chromatography-analysis-of-the-thyroxine-binding-profile
#9
Hidekazu Nagano, Yoshinori Nakagawa, Naofumi Ishikawa, Yuya Watanabe, Yui Miyabayashi, Akitoshi Nakayama, Masanori Fujimoto, Eri Komai, Akina Shiga, Ai Tamura, Takashi Kono, Tomoko Takiguchi, Seiichiro Higuchi, Ikki Sakuma, Naoko Hashimoto, Sawako Suzuki, Hisashi Koide, Kotaro Yokote, Tomoaki Tanaka
OBJECTIVE: Familial dysalbuminemic hyperthyroxinemia (FDH) is caused by abnormal human serum albumin (HSA) with an increased thyroxine (T4) affinity leading to euthyroid hyperthyroxinemia. One- and two-step immunoassay of serum samples from FDH patients (e.g., Japanese patients) with the HSA R218P mutation can yield false-positive free thyroxine (FT4) results. Therefore, it is difficult to distinguish FDH from syndrome of inappropriate secretion of thyroid-stimulating hormone (e.g., syndrome of resistance to thyroid hormone, thyroid-stimulating hormone [TSH]-producing pituitary adenoma), even when multiple assays are used...
August 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28815281/quantitative-characterization-of-colloidal-assembly-of-graphene-oxide-silver-nanoparticle-hybrids-using-aerosol-differential-mobility-coupled-mass-analyses
#10
Thai Phuong Nguyen, Wei-Chang Chang, Yen-Chih Lai, Ta-Chih Hsiao, De-Hao Tsai
In this work, we develop an aerosol-based, time-resolved ion mobility-coupled mass characterization method to investigate colloidal assembly of graphene oxide (GO)-silver nanoparticle (AgNP) hybrid nanostructure on a quantitative basis. Transmission electron microscopy (TEM) and zeta potential (ZP) analysis were used to provide visual information and elemental-based particle size distributions, respectively. Results clearly show a successful controlled assembly of GO-AgNP by electrostatic-directed heterogeneous aggregation between GO and bovine serum albumin (BSA)-functionalized AgNP under an acidic environment...
August 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28812944/binding-forces-between-a-novel-schiff-base-palladium-ii-complex-and-two-carrier-proteins-human-serum-albumi-and%C3%AE-lactoglobulin
#11
Somaye Shahraki, Ali Heydari
Ligand binding studies on carrier proteins are crucial in determining the pharmacological properties of drug candidates. Here, a new palladium(II) complex was synthesized and characterized. The in vitro binding studies of this complexwith two carrier proteins, human serum albumin (HSA) and β-lactoglobulin (βLG) was investigated by employing biophysical techniques as well as computational modeling. The experimental results showed thatthe Pd(II) complex interacted with two carrier proteins with moderate binding affinity (Kb ~̴ 0...
August 16, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28811717/modified-b-ultrasound-method-for-measurement-of-antral-section-only-to-assess-gastric-function-and-guide-enteral-nutrition-in-critically-ill-patients
#12
Ying Liu, Ya-Kun Gao, Lei Yao, Li Li
AIM: To establish a modified B-ultrasound method of measuring the antral section only to assess gastric motility in healthy people, and evaluate its application in guiding enteral nutrition (EN) in critically ill patients. METHODS: First, 30 healthy volunteers were selected. The modified B-ultrasound method and the traditional B-ultrasound method were applied to assess gastric function. The correlation of indices of gastric function between the two groups was analyzed statistically...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28809488/text-displaying-colorimetric-paper-based-analytical-device
#13
Kentaro Yamada, Koji Suzuki, Daniel Citterio
This paper describes a paper-based analytical device allowing the direct semiquantitative interpretation of the result of a chemical assay in the form of "text". The combined use of a classical colorimetric indicator system and an additional inert colorant enables a versatile text-displaying detection mechanism on a paper device. For proof-of-concept, urinary protein has been selected as a model analytical target. The whole text-displaying paper device has been developed based on printing techniques including wax printing, inkjet printing, and 3D printing...
August 15, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28808694/human-serum-albumin-and-oxidative-stress-in-preeclamptic-women-and-the-mechanism-of-albumin-for-stress-reduction
#14
Hiroyuki Kinoshita, Kazushi Watanabe, Toshiharu Azma, Guo-Gang Feng, Takahiko Akahori, Hisaki Hayashi, Motohiko Sato, Yoshihiro Fujiwara, Akihiko Wakatsuki
AIMS: The present study to address one of the mechanisms in preeclampsia, examined whether levels of oxidative stress, human serum albumin, and endothelial function correlate in pregnant women and whether human serum albumin reduces levels of superoxide produced by NADPH oxidase activation in the human vascular smooth muscle cells. MATERIALS AND METHODS: Pregnant women with (Preeclampsia group, n = 33) and without preeclampsia (Normal group, n = 37) were recruited to determine levels of reactive oxygen species (serum diacron-reactive oxygen metabolite [d-ROM]), and the flow-mediated dilation (FMD)...
August 2017: Heliyon
https://www.readbyqxmd.com/read/28808402/role-of-adiantum-philippense-l-on-glucose-uptake-in-isolated-pancreatic-cells-and-inhibition-of-adipocyte-differentiation-in-3t3-l1-cell-line
#15
Tania Paul, Kishori G Apte, Pradeep B Parab, Biswadeep Das
BACKGROUND: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in vivo diabetic model, but the mechanism of action is unknown. OBJECTIVE: AP was found to play a pivotal role in minimizing the high blood glucose in alloxan-induced diabetic rats. Simultaneously, it was observed that it could maintain the normal lipid profile even in diabetic condition. To investigate its insulin-like activity along with its inhibitory role on adipocyte differentiation became the objective of our present study...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28808078/relationship-of-kidney-injury-biomarkers-with-long-term-cardiovascular-outcomes-after-cardiac-surgery
#16
Chirag R Parikh, Jeremy Puthumana, Michael G Shlipak, Jay L Koyner, Heather Thiessen-Philbrook, Eric McArthur, Kathleen Kerr, Peter Kavsak, Richard P Whitlock, Amit X Garg, Steven G Coca
Clinical AKI, measured by serum creatinine elevation, is associated with long-term risks of adverse cardiovascular (CV) events and mortality in patients after cardiac surgery. To evaluate the relative contributions of urine kidney injury biomarkers and plasma cardiac injury biomarkers in adverse events, we conducted a multicenter prospective cohort study of 968 adults undergoing cardiac surgery. On postoperative days 1-3, we measured five urine biomarkers of kidney injury (IL-18, NGAL, KIM-1, L-FABP, and albumin) and five plasma biomarkers of cardiac injury (NT-proBNP, H-FABP, hs-cTnT, cTnI, and CK-MB)...
August 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28806682/photolytic-insertion-of-albumin-on-activated-carbon-modified-with-ozone
#17
Regina de Fátima Peralta Muniz Moreira, Eduardo Humeres, Carolina Berger, M Isabel Fernández, J A Santaballa, Moisés Canle
254nm photolyses of bovine serum albumin [BSA] in aqueous solutions, were carried out in the presence of activated carbons modified by reaction with ozone. The photolyses were monitored by fluorescence spectroscopy and UV spectrophotometry, and the products were characterized by elemental analysis, FTIR, TGA, total organic carbon analyses [TOC], and XPS. The ozonation reaction was carried out at room temperature with O3 under dry and wet conditions. The carbon characterization showed that the reaction increased the amount of epoxide and carbonyl groups on the carbon matrix...
August 2, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28806667/hydrophobic-boron-compound-loaded-poly-l-lactide-co-glycolide-nanoparticles-for-boron-neutron-capture-therapy
#18
Issei Takeuchi, Kensuke Nomura, Kimiko Makino
Poly(DL-lactide-co-glycolide) (PLGA) has been widely used and studied because of its biocompatibility and biodegradability. Recently, the usefulness of nanoparticles using poly(L-lactide-co-glycolide) (PLLGA) having a higher glass transition temperature than PLGA was suggested. In this study, we investigated the availability of boron compound-loaded PLGA and PLLGA nanoparticles for boron neutron capture therapy (BNCT) by conducting biodistribution study using tumor-bearing mice. o-Carborane, a hydrophobic boron compound, was used as a boron carrier, and o-carborane-albumin conjugate was used as a control...
August 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28806645/evaluation-of-the-binding-of-four-anti-tumor-casiope%C3%A3-nas%C3%A2-to-human-serum-albumin
#19
Isabel Correia, Sladjana Borovic, Isabel Cavaco, Cristina P Matos, Somnath Roy, Hugo M Santos, Luz Fernandes, José L Capelo, Lena Ruiz-Azuara, João Costa Pessoa
The metal complexes designated by Casiopeínas® are mixed-ligand Cu(II)-compounds some of them having promising antineoplastic properties. We report studies of binding of Cu(glycinato)(4,7-dimethyl-1,10-phenanthroline) (Cas-II-Gly (1)), Cu(acetylacetonato)(4,7-dimethyl-1,10-phenanthroline) (Cas-III-Ea (2)), Cu(glycinato)(4,4'-dimethyl-2,2'-bipyridine) (Cas-IV-Gly (3)) and Cu(acetylacetonato)(4,4'-dimethyl-2,2'-bipyridine) (Cas-III-ia (4)) to human serum albumin (HSA) by circular dichroism (CD), Electron paramagnetic resonance (EPR) and fluorescence spectroscopy...
July 29, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28804948/nelumbo-nucifera-leaf-extract-treatment-attenuated-preneoplastic-lesions-and-oxidative-stress-in-the-livers-of-diethylnitrosamine-treated-rats
#20
Chi-Ting Horng, Chien-Wei Huang, Mon-Yuan Yang, Tzu-Hsin Chen, Yun-Ching Chang, Chau-Jong Wang
Lotus (Nelumbo nucifera Gaertn) possesses antioxidant, hepatoprotective, and anticancer potential. This study determined the protective role of aqueous extract from Nelumbo nucifera leaves (NLE) against N-diethylnitrosamine (DEN)-induced oxidative stress and hepatocellular carcinogenesis in a sample of Sprague-Dawley rats. NLE was fed orally to rats in which hepatic carcinoma was induced with DEN for 12 weeks. Five groups of 12 rats each were used for the study: Group I (control group) rats received distilled water; Group II rats were induced with DEN; Group III rats were induced with DEN and cotreated with 0...
August 14, 2017: Environmental Toxicology
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