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https://www.readbyqxmd.com/read/29345310/a-potential-role-of-knockout-serum-replacement-as-a-porcine-follicular-fluid-substitute-for-in-vitro-maturation-lipid-metabolism-approach
#1
Jun-Xue Jin, Sanghoon Lee, Erif Maha Nugraha Setyawan, Anukul Taweechaipaisankul, Geon A Kim, Ho Jae Han, Curie Ahn, Byeong Chun Lee
The use of supplements, such as porcine follicular fluid (pFF), fetal bovine serum and human serum albumin are widely used during in vitro maturation (IVM) in different species but these supplements contain undefined components that cause technical difficulties in standardization and influence the efficiency of IVM. Knockout serum replacement (KSR) is a synthetic protein source, without any undefined growth factors or differentiation-promoting factors. Therefore, it is feasible to use KSR as a defined component for avoiding effects of unknown molecules in an IVM system...
January 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29345202/qualitative-and-semiquantitative-analysis-of-the-protein-coronas-associated-to-different-functionalized-nanoparticles
#2
Francesca Pederzoli, Giovanni Tosi, Filippo Genovese, Daniela Belletti, Maria Angela Vandelli, Antonio Ballestrazzi, Flavio Forni, Barbara Ruozi
AIM: The investigation on protein coronas (PCs) adsorbed onto nanoparticle (NP) surface is representing an open issue due to difficulties in detection and clear isolation of the adsorbed proteins. In this study, we investigated protocols able to isolate the compositions of PCs of three polymeric NPs. MATERIALS & METHODS: Unfunctionalized NPs and two functionalized NPs were considered as proof-of-concept for the qualitative and semiquantitative analysis of both the corona levels (stably or weakly adsorbed coronas [SC/WC]) of these different nanocarriers...
January 18, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29344688/inflammation-based-prognostic-score-predicts-postoperative-survival-of-patients-with-interstitial-pneumonia-after-undergoing-lung-cancer-resection
#3
Satoru Kobayashi, Yuji Matsumura, Yoko Karube, Morimichi Nishihira, Takashi Inoue, Osamu Araki, Sumiko Maeda, Masayuki Chida
OBJECTIVES: Idiopathic interstitial pneumonias (IIPs) are associated with an increased risk of lung cancer. Glasgow prognostic score (GPS), which uses serum C-reactive protein (CRP) and albumin levels to indicate systemic inflammatory response and nutrition level, has been reported to be a predictor of overall survival in patients with various types of cancer. We evaluated the usefulness of GPS for prediction of survival of patients with both lung cancer and IIPs following a lung resection procedure...
January 17, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29344514/portal-vein-embolization-history-and-current-indications
#4
REVIEW
Hiroji Shinkawa, Shigekazu Takemura, Shogo Tanaka, Shoji Kubo
Portal vein embolization (PVE) was first adapted for patients undergoing major hepatectomy for hepatocellular carcinoma (HCC). In these patients, PVE caused hypertrophy of the unaffected liver and increased the volumetric ratio of future liver remnant (FLR) to total liver volume. 99mTechnetium-galactosyl human serum albumin (99mTc-GSA) scintigraphy revealed that PVE also induced a shift in hepatic function from the embolized part to the nonembolized part of the liver. Various hepatobiliary malignancies can be treated using PVE, and PVE is increasingly being used to expand the indication for major hepatectomy in patients with initially insufficient FLR volume or function...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29343812/high-albumin-level-is-a-predictor-of-favorable-response-to-immunotherapy-in-autoimmune-encephalitis
#5
Yoonhyuk Jang, Soon-Tae Lee, Tae-Joon Kim, Jin-Sun Jun, Jangsup Moon, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Sang Kun Lee
There is no known biomarker that predicts the response to immune therapy in autoimmune synaptic encephalitis. Thus, we investigated serum albumin as a prognostic biomarker of early immune therapies in patients with autoimmune encephalitis. We enrolled patients who were diagnosed with definite autoimmune encephalitis and underwent IVIg treatment at Seoul National University Hospital from 2012 to 2017. Patients were dichotomized according to serum albumin prior to IVIg administration with a cut-off level of 4...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342320/association-of-pre-esrd-serum-calcium-with-post-esrd-mortality-among-incident-esrd-patients-a-cohort-study
#6
Yoshitsugu Obi, Christina Park, Melissa Soohoo, Keiichi Sumida, Takayuki Hamano, Connie M Rhee, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Elani Streja
Albumin-corrected serum calcium (cSCa) decline at late stages of chronic kidney disease and rise after dialysis initiation. While hypercalcemia is associated with higher mortality in end-stage renal disease (ESRD), there are scarce data on the impact of pre-ESRD cSCa on post-ESRD mortality. Therefore, we used a large national cohort of 21,826 US veterans with incident ESRD who transitioned to dialysis in all US Department of Veterans Affairs healthcare facilities over 2009-2014 to examine the associations with all-cause and cause-specific post-ESRD mortality of (1) cSCa concentrations averaged over the last six months and (2) its rate of decline during the last 12 months before dialysis initiation...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29340964/geriatric-nutritional-risk-index-as-a-simple-tool-for-assessment-of-malnutrition-among-geriatrics-in-northwest-of-iran-comparison-with-mini-nutritional-assessment
#7
Maryam Saghafi-Asl, Elnaz Vaghef-Mehrabany, Nahid Karamzad, Lida Daeiefarshbaf, Parinaz Kalejahi, Mohammad Asghari-Jafarabadi
BACKGROUND: Older people are more likely to develop nutritional problems and timely diagnosis of malnutrition is crucial to prevent hazardous consequences following poor nutrition. AIMS: To evaluate the efficacy of Geriatric Nutritional Risk Index (GNRI) to assess nutritional status among non-hospitalized elderly, compared to mini nutritional assessment (MNA) among Iranian seniors. METHODS: One hundred and sixty-four subjects, aged ≥ 65 years old were recruited to our cross-sectional study from various districts of Tabriz (Tabriz, Iran)...
January 16, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29340818/changes-in-plasma-albumin-levels-in-early-detection-of-infectious-complications-after-laparoscopic-colorectal-cancer-surgery-with-eras-protocol
#8
Mateusz Wierdak, Magdalena Pisarska, Beata Kuśnierz-Cabala, Jan Witowski, Jadwiga Dworak, Piotr Major, Piotr Małczak, Piotr Ceranowicz, Andrzej Budzyński, Michał Pędziwiatr
BACKGROUND: Combination of laparoscopic approach with ERAS protocol in colorectal surgery allows for an early discharge. However there is a risk that some of the discharged patients are developing, asymptomatic at the time, infectious complications. This may lead to a delay in diagnostics and proper treatment introduction. We aimed to assess the usefulness of preoperative plasma albumin concentration and their changes as indicators of infectious complications in patients undergoing colorectal cancer surgery...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29340242/a-diagnostic-model-for-minimal-change-disease-based-on-biological-parameters
#9
Hanyu Zhu, Qiuxia Han, Dong Zhang, Yong Wang, Jing Gao, Wenjia Geng, Xiaoli Yang, Xiangmei Chen
Background: Minimal change disease (MCD) is a kind of nephrotic syndrome (NS). In this study, we aimed to establish a mathematical diagnostic model based on biological parameters to classify MCD. Methods: A total of 798 NS patients were divided into MCD group and control group. The comparison of biological indicators between two groups were performed with t-tests. Logistic regression was used to establish the diagnostic model, and the diagnostic value of the model was estimated using receiver operating characteristic (ROC) analysis...
2018: PeerJ
https://www.readbyqxmd.com/read/29338573/triphenylphosphine-docetaxel-conjugate-incorporated-albumin-nanoparticles-for-cancer-treatment
#10
Gantumur Battogtokh, Oyuntuya Gotov, Jee He Kang, Jinsung Cho, Tae Ho Jeong, Ganzorig Chimed, Young Tag Ko
AIM: The objective of this study was to develop a mitochondria-targeted anticancer drug, docetaxel (DTX), for chemotherapy. MATERIALS & METHODS: The DTX was conjugated to 4-carboxybutyl triphenylphosphonium (TPP) to enhance mitochondrial targeting, and the TPP-DTX conjugate was further loaded into folate-cholesteryl albumin (FA-chol-BSA) nanoparticles (NPs) to improve its biocompatibility. RESULTS & CONCLUSION: In vitro studies showed that TPP-DTX and its NP primarily accumulated in the mitochondria; generated high reactive oxygen species, leading to mitochondrial disruption and cell apoptosis; and had a higher cytotoxicity against cancer cells...
January 17, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29338066/endoscopic-scoring-indices-for-evaluation-of-disease-activity-in-ulcerative-colitis
#11
REVIEW
Nadia Mohammed Vashist, Mark Samaan, Mahmoud H Mosli, Claire E Parker, John K MacDonald, Sigrid A Nelson, G Y Zou, Brian G Feagan, Reena Khanna, Vipul Jairath
BACKGROUND: Endoscopic assessment of mucosal disease activity is routinely used to determine eligibility and response to therapy in clinical trials of ulcerative colitis. The operating properties of the existing endoscopic scoring indices are unclear. OBJECTIVES: A systematic review was undertaken to evaluate the development and operating characteristics of endoscopic scoring indices for the evaluation of ulcerative colitis. SEARCH METHODS: We searched MEDLINE, Embase and CENTRAL from inception to 5 July 2016...
January 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29336752/external-validation-of-velazquez-gomez-severity-score-index-and-atlas-scores-and-the-identification-of-risk-factors-associated-with-mortality-in-clostridium-difficile-infections
#12
Matthew L Figh, Evon S L Zoog, Richard A Moore, Benjamin W Dart, Gregory Heath, Reed M Butler, Cuilan Gao, Joseph C Kong, J Daniel Stanley
Treatment guidelines for Clostridium difficile infection (CDI) are limited by a lack of widely accepted clinical prediction tools (CPTs). Two published CPTs, the Velazquez-Gomez Severity Score Index (VGSSI) and ATLAS scores, were evaluated, and variables showing the greatest correlation with mortality in patients with CDI were identified to further develop an objective, mortality-based CPT. A retrospective review of the charts of 271 hospitalized patients with CDI was performed. VGSSI and ATLAS scores were assigned...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29336202/the-prediction-value-of-the-systemic-inflammation-score-for-oral-cavity-squamous-cell-carcinoma
#13
Yousif I Eltohami, Huang-Kai Kao, William Wei-Kai Lao, Yenlin Huang, Mohamed Abdelrahman, Chun-Ta Liao, Tzu-Chen Yen, Kai-Ping Chang
Objectives This study aimed to investigate the potential prognostic role of the oral cancer systemic inflammation score (SIS) based on serum albumin levels and the lymphocyte-to-monocyte ratio in patients with oral squamous cell carcinoma (OSCC) after treatment. Study Design A retrospective cohort study. Setting Tertiary care center. Subjects and Methods The study involved 613 patients who were treated for OSCC between September 2005 and December 2014. The association of the oral cancer SIS with various clinicopathological features was investigated...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29334554/the-systemic-immune-inflammation-index-independently-predicts-survival-and-recurrence-in-resectable-pancreatic-cancer-and-its-prognostic-value-depends-on-bilirubin-levels-a-retrospective-multicenter-cohort-study
#14
Mohammad Hosein Aziz, Kostandinos Sideras, Nasir Ahmad Aziz, Katya Mauff, Roel Haen, Daphne Roos, Lawlaw Saida, Mustafa Suker, Erwin van der Harst, Jan Sven Mieog, Bert A Bonsing, Yarne Klaver, Bas Groot Koerkamp, Casper H van Eijck
OBJECTIVE: Our aim was to determine the prognostic significance of the systemic-immune-inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific survival as the primary outcome. BACKGROUND: Pancreatic cancer is associated with a dysfunctional immune system and poor prognosis. We examined the prognostic significance of the SIII in patients with resectable pancreatic ductal adenocarcinoma (PDAC) and the effects of bilirubin on this index...
January 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29333945/remarkable-response-with-pembrolizumab-plus-albumin-bound-paclitaxel-in-2-cases-of-her2-positive-metastatic-breast-cancer-who-have-failed-to-multi-anti-her2-targeted-therapy
#15
Bian Li, Wang Tao, Zhang Shao-Hua, Q U Ze-Rui, Jin Fu-Quan, L I Fan, Jiang Ze-Fei
In clinical practice, one subgroup patients of breast cancer might have developed resistance to multi-anti-HER2 targeted drugs(trastuzumab,lapatinib and/or T-DM1) and can not benefit from the anti-HER2 targeted therapy continuously. We attempt to change the next therapic way for these patients.Two patients with metastatic breast cancer who have failed to multi-anti-HER2 targeted therapy were treated with pembrolizumab(2mg/Kg, day1) plus albumin-bound paclitaxel(125mg/m2, day1,8) every 3 weeks.CT evaluation and HER2 ECD test were performed every 2 cycles...
January 15, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29333051/therapeutic-significance-of-loligo-vulgaris-lamarck-1798-ink-extract-a-biomedical-approach
#16
Sri Kumaran Nadarajah, Radha Vijayaraj, Jayaprakashvel Mani
Background: The squid ink extract is well known for its biomedical properties. Objective: In this study, squid Loligo vulgaris was collected from Tuticorin costal water, Bay of Bengal, India. Materials and Methods: Proximate composition of the crude squid ink was studied and found to have protein as the major component over lipid and carbohydrates. Further, bioactive fractions of squid ink were extracted with ethanol, and therapeutic applications such as hemolytic, antioxidant, antimicrobial, and in vitro anti-inflammatory properties were analyzed using standard methods...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29328653/extending-half-life-of-h-ferritin-nanoparticle-by-fusing-albumin-binding-domain-for-doxorubicin-encapsulation
#17
Chunyue Wang, Chun Zhang, Zenglan Li, Shuang Yin, Qi Wang, Fangxia Guo, Yao Zhang, Rong Yu, Yongdong Liu, Zhiguo Su
Nanoparticles based on the heavy chain of the human ferritin (HFn) are arousing growing interest in the field of drug-delivery due to their exceptional characteristics. However, the unsatisfied plasma half-life of HFn substantially limits its application as a delivery platform for anti-tumor agents. Herein, we fused an albumin binding domain (ABD) variant which basically derives from the streptococcal protein G and possesses a long-acting characteristic in serum albumin to the N-terminus of the HFn for the aim of half-life extension...
January 12, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29328489/antibody-nanoparticle-conjugate-constructed-with-trastuzumab-and-nanoparticle-albumin-bound-paclitaxel-for-targeted-therapy-of-human-epidermal-growth-factor-receptor%C3%A2-2-positive-gastric-cancer
#18
Jian Xiong, Shuhua Han, Shuang Ding, Jingchao He, Haijun Zhang
Gastric cancer (GC) is the most lethal malignancy in the digestive system. This study investigated an antibody-nanoparticle conjugate (ANC) constructed with trastuzumab (Herceptin®) and nanoparticle albumin-bound paclitaxel (nab-paclitaxel, Abraxane®) (trastuzumab/nab‑paclitaxel) as a novel strategy of targeted therapy for human epidermal growth factor receptor 2 (HER2) positive GC. The ANC was fabricated with trastuzumab and nab‑paclitaxel by a 'one-step' synthesis using EDC/NHS. In vitro antitumor efficacy was evaluated by cell viability, apoptosis rate and cell cycle of HER2-positive GC NCI‑N87 cells and compared with paclitaxel (Taxol®), nab‑paclitaxel and trastuzumab/nab‑paclitaxel...
January 9, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29327005/vivo-complexes-with-antibacterial-quinolone-ligands-and-their-interaction-with-serum-proteins
#19
Daniele Sanna, Valeria Ugone, Giuseppe Sciortino, Péter Buglyó, Zsolt Bihari, Péter László Parajdi-Losonczi, Eugenio Garribba
Quinolone derivatives are among the most commonly prescribed antibacterials in the world and could also attract interest as organic ligands in the design of metal complexes with potential pharmacological activity. In this study, five compounds, belonging to the first (nalidixic acid or Hnal), second (ciprofloxacin or Hcip, and norfloxacin or Hnor) and third generation (levofloxacin or Hlev, and sparfloxacin or Hspar) of quinolones, were used as ligands to bind the VIVO2+ ion. In aqueous solution, mono- and bis-chelated species were formed as a function of pH, with cis-[VOHxL2(H2O)]x+ and [VOHxL2]x+, x = 0-2, being the major complexes at pH 7...
January 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29326881/interaction-of-anthraquinones-of-cassia-occidentalis-seeds-with-dna-and-glutathione
#20
Gati Krushna Panigrahi, Neeraj Verma, Nivedita Singh, Somya Asthana, Shailendra K Gupta, Anurag Tripathi, Mukul Das
Consumption of Cassia occidentalis (CO) seeds has been associated with the hepatomyoencephalopathy (HME) in children. Recently, we have characterized the toxic anthraquinones (AQs) such as Emodin, Rhein, Aloe-emodin, Chrysophanol and Physcion in CO seeds and detected these moieties in the bio fluids of CO poisoning cases. As AQs were detected in the serum of HME patients, their interaction with key biomolecules including protein, DNA and glutathione (GSH) is imperative. In this regard, we have previously reported the interaction of these AQs with serum albumin protein and their subsequent biological effects...
2018: Toxicology Reports
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