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https://www.readbyqxmd.com/read/28334528/why-prodrugs-and-propesticides-succeed
#1
John E Casida
What are the advantages of bioactivation in optimizing drugs and pesticides? Why are there so many prodrugs and propesticides? These questions are examined here by considering compounds selected on the basis of economic value or market success. The 100 major drugs and 90 major pesticides are divided into ones acting directly and those definitely or possibly requiring bioactivation. Established or candidate prodrugs accounted for 19% of the total drug sales with corresponding values of 20, 37 and 17% for proinsecticides, proherbicides and profungicides...
March 23, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28333214/-forever-young-%C3%A2-testosterone-replacement-therapy-a-blockbuster-drug-despite-flabby-evidence-and-broken-promises
#2
Andrea Busnelli, Edgardo Somigliana, Paolo Vercellini
In the last decade, testosterone replacement therapy (TRT) has been increasingly prescribed to treat a controversial condition known as 'late-onset hypogonadism (LOH)'. This syndrome is diagnosed in men who, for no discernible reason other than older age, obesity or ill health have serum testosterone concentrations below the normal range for healthy young men and report one or more of the following symptoms: muscle weakness or wasting, mood, behaviour and cognition-related symptoms and sexual function or libido impairment...
February 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28317512/alcohol-industry-sponsorship-of-university-student-sports-clubs-in-brazil
#3
Ilana Pinsky, Ana Regina Noto, Maria Carolina Botéquio de Moraes, Elaine Lucas Dos Santos, Robert Sparks, Kerry O'Brien
OBJECTIVE: The university sport environment represents an important target for alcohol industry marketing. This study investigated the nature of relationships between the alcohol industry and university student sports clubs (USSCs). METHOD: Semi-structured interviews were conducted with board members from 60 active USSCs in the city of São Paulo, Brazil. Interviews were transcribed and subjected to content analysis using NVivo10. RESULTS: All invited USSCs participated in the study...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28317004/changes-in-the-mass-merchandise-cigar-market-since-the-tobacco-control-act
#4
Cristine D Delnevo, Daniel P Giovenco, Erin J Miller Lo
OBJECTIVES: This study identifies the specific product characteristics driving mass-merchandise cigar sales in the context of the changing regulatory environment. METHODS: Cigar sales data in US convenience stores during 2008-2015 were purchased from Nielsen's Convenience Track system. Descriptive statistics highlight changes in the cigar market over time. RESULTS: Sales of flavored cigars increased by nearly 50% since 2008 and now make up over half of the cigar market...
April 2017: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28316037/early-impacts-of-a-healthy-food-distribution-program-on-the-availability-and-price-of-fresh-fruits-and-vegetables-in-small-retail-venues-in-los-angeles
#5
Amelia R DeFosset, Lauren N Gase, Eliza Webber, Tony Kuo
Healthy food distribution programs that allow small retailers to purchase fresh fruits and vegetables at wholesale prices may increase the profitability of selling produce. While promising, little is known about how these programs affect the availability of fresh fruits and vegetables in underserved communities. This study examined the impacts of a healthy food distribution program in Los Angeles County over its first year of operation (August 2015-2016). Assessment methods included: (1) a brief survey examining the characteristics, purchasing habits, and attitudes of stores entering the program; (2) longitudinal tracking of sales data examining changes in the volume and variety of fruits and vegetables distributed through the program; and (3) the collection of comparison price data from wholesale market databases and local grocery stores...
March 18, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28315761/a-growing-geographic-disparity-rural-and-urban-cigarette-smoking-trends-in-the-united-states
#6
N J Doogan, M E Roberts, M E Wewers, C A Stanton, D R Keith, D E Gaalema, A N Kurti, R Redner, A Cepeda-Benito, J Y Bunn, A A Lopez, S T Higgins
Rural areas of the United States have a higher smoking prevalence than urban areas. However, no recent studies have rigorously examined potential changes in this disparity over time or whether the disparity can be explained by demographic or psychosocial characteristics associated with smoking. The present study used yearly cross sectional data from the National Survey on Drug Use and Health from 2007 through 2014 to examine cigarette smoking trends in rural versus urban areas of the United States. The analytic sample included 303,311 respondents...
March 15, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28306750/optimal-pricing-and-marketing-planning-for-deteriorating-items
#7
Seyed Reza Moosavi Tabatabaei, Seyed Jafar Sadjadi, Ahmad Makui
Optimal pricing and marketing planning plays an essential role in production decisions on deteriorating items. This paper presents a mathematical model for a three-level supply chain, which includes one producer, one distributor and one retailer. The proposed study considers the production of a deteriorating item where demand is influenced by price, marketing expenditure, quality of product and after-sales service expenditures. The proposed model is formulated as a geometric programming with 5 degrees of difficulty and the problem is solved using the recent advances in optimization techniques...
2017: PloS One
https://www.readbyqxmd.com/read/28271984/need-for-desire-drugs-debated
#8
Jan Greene
Some see a big market for medications for low libido in women. But sales of Addyi have been slow. Has a normal experience been unnecessarily medicalized? One of many factors in the debate is whether women#x02019;s sexual response tends to be more spontaneous or responsive.
February 2017: Managed Care
https://www.readbyqxmd.com/read/28264485/effect%C3%A2-of%C3%A2-25-%C3%A2-sodium%C3%A2-reduction%C3%A2-on%C3%A2-sales%C3%A2-of%C3%A2-%C3%A2-a%C3%A2-top-selling%C3%A2-bread%C3%A2-in%C3%A2-remote%C3%A2-indigenous%C3%A2-australian%C3%A2-community%C3%A2-stores-%C3%A2-a%C3%A2-controlled%C3%A2-intervention%C3%A2-trial
#9
Emma McMahon, Jacqui Webster, Julie Brimblecombe
Reducing sodium in the food supply is key to achieving population salt targets, but maintaining sales is important to ensuring commercial viability and maximising clinical impact. We investigated whether 25% sodium reduction in a top-selling bread affected sales in 26 remote Indigenous community stores. After a 23-week baseline period, 11 control stores received the regular-salt bread (400 mg Na/100 g) and 15 intervention stores received the reduced-salt version (300 mg Na/100 g) for 12-weeks. Sales data were collected to examine difference between groups in change from baseline to follow-up (effect size) in sales (primary outcome) or sodium density, analysed using a mixed model...
February 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28264077/association-of-a-community-campaign-for-better-beverage-choices-with-beverage-purchases-from-supermarkets
#10
Marlene B Schwartz, Glenn E Schneider, Yoon-Young Choi, Xun Li, Jennifer Harris, Tatiana Andreyeva, Maia Hyary, Nicolette Highsmith Vernick, Lawrence J Appel
Importance: Data are needed to evaluate community interventions to reduce consumption of sugary drinks. Supermarket sales data can be used for this purpose. Objective: To compare beverage sales in Howard County, Maryland (HC), with sales in comparison stores in a contiguous state before and during a 3-year campaign to reduce consumption of sugary beverages. Design, Setting, and Partipicants: This observational experiment with a control group included 15 HC supermarkets and 17 comparison supermarkets...
March 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28257998/the-battle-of-nano-paclitaxel
#11
REVIEW
Alexandros Marios Sofias, Michael Dunne, Gert Storm, Christine Allen
Paclitaxel (PTX) is one of the three most widely used chemotherapeutic agents, together with doxorubicin and cisplatin, and is first or second line treatment for several types of cancers. In 2000, Taxol, the conventional formulation of PTX, became the best selling cancer drug of all time with annual sales of 1.6 billion. In 2005, the introduction of the albumin-based formulation of PTX, known as Abraxane, ended Taxol's monopoly of the PTX market. Abraxane's ability to push the Taxol innovator and generic formulations aside attracted fierce competition amongst competitors worldwide to develop their own unique, new and improved formulation of PTX...
February 28, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28256584/risk-factors-for-avian-influenza-virus-contamination-of-live-poultry-markets-in-zhejiang-china-during-the-2015-2016-human-influenza-season
#12
Xiaoxiao Wang, Qimei Wang, Wei Cheng, Zhao Yu, Feng Ling, Haiyan Mao, Enfu Chen
Live bird markets (LBMs), being a potential source of avian influenza virus, require effective environmental surveillance management. In our study, a total of 2865 environmental samples were collected from 292 LBMs during the 2015-2016 human influenza season from 10 cities in Zhejiang province, China. The samples were tested by real-time quantitative polymerase chain reaction (RT-PCR). Field investigations were carried out to investigate probable risk factors. Of the environmental samples, 1519 (53.0%) were contaminated by A subtype...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28252603/-modeling-of-an-influence-of-indicators-of-social-stress-on-demographic-processes-in-regions-of-the-russian-federation
#13
M M Burkin, E V Molchanova
AIM: To assess an impact of indicators of social stress on demographic processes in regions of the Russian Federation using statistical methods. MATERIAL AND METHODS: The data of Rosstat «Regions of Russia» and «Health care in Russia» were used as information base. Indicators of about 80 subjects of the Russian Federation (without autonomous areas) for the ten-year period (2005-2014) have been created in the form of the database consisting of the following blocks: medico-demographic situation, level of economic development of the territory and wellbeing of the population, development of social infrastructure, ecological and climatic conditions, scientific researches and innovations...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28249822/ethnobotanical-survey-of-herbal-tea-plants-from-the-traditional-markets-in-chaoshan-china
#14
Dong-Lin Li, Xi-Long Zheng, Lei Duan, Shuang-Wen Deng, Wen Ye, Ai-Hua Wang, Fu-Wu Xing
ETHNOPHARMACOLOGICAL RELEVANCE: Herbal tea, which refers to "cooling tea", "cool beverage", or "liáng chá" in China, includes a range of drinks with heat-clearing and detoxification qualities. Herbal tea plants are great contributive to the health and prosperity of Chaoshan people. The aim of the study was to document herbal tea plant species used and commercialized as "liáng chá" in Chaoshan area, to facilitate the use and development of herbal tea enterprises, and to promote the further development of national herbal tea...
February 26, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28246502/marketing-research-on-the-angiotensin-converting-enzyme-inhibitors-antihypertensive-medicines
#15
Anamaria Boboia, Marius Rareş Grigorescu, Adina Turcu-Ştiolică
BACKGROUND AND AIMS: The research aimed at investigating sales trends of angiotensin-converting enzyme inhibitors antihypertensive medicines, both in terms of quantity and value, in ten community pharmacies, for a period of three years. The research on the antihypertensive medicines consumption is important for highlighting the ever increasing impact of hypertension among the population. METHODS: The methods used in this research were the following: marketing research, method of sampling, descriptive methods, retrospective analysis, method of comparison...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28221976/listeria-monocytogenes-in-smoked-salmon-and-other-smoked-fish-at-retail-in-italy-frequency-of-contamination-and-strain-characterization-in-products-from-different-manufacturers
#16
Vicdalia Aniela Acciari, Marina Torresi, Luigi Iannetti, Silvia Scattolini, Francesco Pomilio, Lucia Decastelli, Silvia Colmegna, Riccardo Muliari, Teresa Bossù, Yolande Proroga, Cosimo Montagna, Cinzia Cardamone, Paola Cogoni, Vincenza Annunziata Prencipe, Giacomo Migliorati
Seven hundred seventy-eight samples of packaged smoked fish (774 smoked salmon and 4 smoked swordfish) on sale in Italy, from 50 different manufacturers located in 12 European Union countries, were purchased from the Italian market between May and December 2011. The surface temperatures of the samples on sale ranged from 0 to 13°C (3.4 ± 1.5°C, mean ± SD). Six hundred eighty (87.4%) of 778 samples were stored at ≤4°C. One hundred fifty-seven samples (20.2%, 95% confidence interval 17.5 to 23.1%) were contaminated by Listeria monocytogenes , with 26 samples (3...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28216007/microbiological-quality-of-pastrami-and-associated-surfaces-at-the-point-of-sale-in-kayseri-turkey
#17
Y Yildirim, N Ertas Onmaz, Z Gonulalan, S Al, A Yildirim, F Karadal, H Hizlisoy, Ş Pamuk
OBJECTIVE: The aim of this study is to trace the possible relations between the hygienic status of slicing utensils and the microbiological quality of pastrami. STUDY DESIGN: A total of 75 pastrami retail markets were visited in Kayseri, Turkey, where the pastrami (a ready-to-eat meat product) is commonly produced and consumed. Sliced pastrami, the cutting board and knife surface swabs were collected from each pastrami retail point to trace possible sources of contamination...
February 16, 2017: Public Health
https://www.readbyqxmd.com/read/28215387/dissemination-of-technology-to-evaluate-healthy-food-incentive-programs
#18
Darcy A Freedman, Alan R Hunt, Katie Merritt, En-Jung Shon, Stephanie N Pike
INTRODUCTION: Federal policy supports increased implementation of monetary incentive interventions for chronic disease prevention among low-income populations. This study describes how a Prevention Research Center, working with a dissemination partner, developed and distributed technology to support nationwide implementation and evaluation of healthy food incentive programming focused on Supplemental Nutrition Assistance Program recipients. METHODS: FM Tracks, an iOS-based application and website, was developed to standardize evaluation methods for healthy food incentive program implementation at direct-to-consumer markets...
March 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28212972/variation-in-health-technology-assessment-and-reimbursement-processes-in-europe
#19
Ronald L Akehurst, Eric Abadie, Noël Renaudin, François Sarkozy
BACKGROUND: It has been suggested that differences in health technology assessment (HTA) processes among countries, particularly within Europe, have led to inequity in patient access to new medicines. OBJECTIVES: To provide an up-to-date snapshot analysis of the present status of HTA and reimbursement systems in select European countries, and to investigate the implications of these processes, especially with regard to delays in market and patient access. METHODS: HTA and reimbursement processes were assessed through a review of published and gray literature, and through a series of interviews with HTA experts...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28211112/impact-of-a-targeted-direct-marketing-price-promotion-intervention-buywell-on-food-purchasing-behaviour-by-low-income-consumers-a-randomised-controlled-trial
#20
M Stead, A M MacKintosh, A Findlay, L Sparks, A S Anderson, K Barton, D Eadie
BACKGROUND: Price promotions are a promising intervention for encouraging healthier food purchasing. We aimed to assess the impact of a targeted direct marketing price promotion combined with healthy eating advice and recipe suggestions on the purchase of selected healthier foods by low income consumers. METHODS: We conducted a randomised controlled trial (n = 53 367) of a direct marketing price promotion (Buywell) combined with healthy eating advice and recipe suggestions for low income consumers identified as 'less healthy' shoppers...
February 17, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
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