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https://www.readbyqxmd.com/read/28642701/the-market-of-biopharmaceutical-medicines-a-snapshot-of-a-diverse-industrial-landscape
#1
Evelien Moorkens, Nicolas Meuwissen, Isabelle Huys, Paul Declerck, Arnold G Vulto, Steven Simoens
Background: Biopharmaceutical medicines represent a growing share of the global pharmaceutical market, and with many of these biopharmaceutical products facing loss of exclusivity rights, also biosimilars may now enter the biopharmaceutical market. Objectives: This study aims to identify and document which investment and development strategies are adopted by industrial players in the global biopharmaceutical market. Methods: A descriptive analysis was undertaken of the investment and development strategies of the top 25 pharmaceutical companies according to 2015 worldwide prescription drug sales...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28641892/fighting-fake-medicines-first-quality-evaluation-of-cardiac-drugs-in-africa
#2
Marie Antignac, Bara Ibrahima Diop, Diane Macquart de Terline, Melisande Bernard, Bernard Do, Stéphane Méo Ikama, Roland N'Guetta, Dadhi M Balde, Yessoufou Tchabi, Abdallahi Sidi Aly, Ibrahim Ali Toure, Patrick Zabsonre, Jean Marie F Damorou, Jean Laurent Takombe, Christine Fernandez, Muriel Tafflet, Jean Philippe Empana, Pierre François Plouin, Kumar Narayanan, Eloi Marijon, Xavier Jouven
BACKGROUND: The growing menace of poor quality and falsified drugs constitutes a major hazard, compromising healthcare and patient outcomes. Efforts to assess drug standards worldwide have almost exclusively focused on anti-microbial drugs; with no study to date on cardiovascular drugs. Our study aims to assess quality of seven routinely used cardiovascular medications (anticoagulants, antihypertensives and statins) in ten Sub-Saharan African countries. METHODS: Drugs were prospectively collected using standardized methods between 2012 and 2014 from licensed (random pharmacies) and unlicensed (street-markets) places of sale in Africa...
June 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28638314/in-person-retail-marketing-claims-in-tobacco-and-e-cigarette-shops-in-southern-california
#3
Joshua S Yang, Michele M Wood, Katelynn Peirce
BACKGROUND: E-cigarette use has been increasing in the United States, though knowledge of potential risks and harms associated with e-cigarette use is low. Marketing of e-cigarettes may serve as a source of information to shape beliefs and attitudes toward e-cigarettes. The purpose of this study was to identify the most common marketing claims made within "vape" and tobacco shops in sales interactions with customers in demographically diverse cities. METHODS: Vape and tobacco shops from three diverse cities in Southern California were selected for inclusion in the study...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28631504/remote-ischemic-conditioning-the-commercial-market-lifecuff-perspective
#4
Kirk N Garratt, Boris Leschinsky
Although remote ischemic conditioning promises significant benefit to patients with a variety of acute and chronic illnesses, development of automated, clinically applicable devices has been slow. At least 3 small companies have launched efforts to develop useful tools intended for sale in European and North American markets. The market challenges and opportunities linked to the development of a cost-effective, reliable, and clinically effective device for the application of remote ischemic conditioning are presented in this article...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28630559/drug-policy-and-indigenous-peoples
#5
Julian Burger, Mary Kapron
This paper identifies the principal concerns of indigenous peoples with regard to current international treaties on certain psychoactive substances and policies to control and eradicate their production, trafficking, and sale. Indigenous peoples have a specific interest in the issue since their traditional lands have become integrated over time into the large-scale production of coca, opium poppy, and cannabis crops, in response to high demand from the American and European markets, among others. As a consequence, indigenous peoples are persecuted because of their traditional use of these and other plant-based narcotics and hallucinogens...
June 2017: Health and Human Rights
https://www.readbyqxmd.com/read/28620465/nanoparticle-based-drug-delivery-systems-what-can-they-really-do-in-vivo
#6
REVIEW
Yi-Feng Wang, Lu Liu, Xue Xue, Xing-Jie Liang
In the past few decades, there has been explosive growth in the construction of nanoparticle-based drug delivery systems (NDDSs), namely nanomedicines, owing to their unique properties compared with traditional drug formulations. However, because of a variety of challenges, few nanomedicines are on sale in the market or undergoing clinical trial at present. Thus, it is essential to look back and re-evaluate what these NDDSs can really do in vivo, why nanomedicines are regarded as potential candidates for next-generation drugs, and what the future of nanomedicine is...
2017: F1000Research
https://www.readbyqxmd.com/read/28617997/a-market-on-both-sides-of-the-law-the-use-of-the-hidden-web-for-the-sale-of-new-psychoactive-substances
#7
Elle Wadsworth, Colin Drummond, Andreas Kimergård, Paolo Deluca
OBJECTIVE: The hidden Web is used for the anonymous sale of drugs, and with the UK Psychoactive Substances Act, 2016, implemented on May 26th 2016; it could increase as a platform for obtaining new psychoactive substances (NPS). This study aims to describe the NPS market on the visible and hidden Web preban, and assess whether the hidden Web is a likely place for the sale of NPS postban. METHODS: Data collection of 113 online shops took place in October 2015. Data collection of 22 cryptomarkets took place every 2 months from October 2015 to 2016 as part of the CASSANDRA project...
June 15, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28605866/effect-of-temporary-open-air-markets-on-the-sound-environment-and-acoustic-perception-based-on-the-crowd-density-characteristics
#8
Qi Meng, Yang Sun, Jian Kang
The sound environment and acoustic perception of open-air markets, which are very common in high-density urban open spaces, play important roles in terms of the urban soundscape. Based on objective and subjective measurements of a typical temporary open-air market in Harbin city, China, the effects of the temporary open-air market on the sound environment and acoustic perception were studied, considering different crowd densities. It was observed that a temporary open-air market without zoning increases the sound pressure level and subjective loudness by 2...
June 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28605615/cancer-drugs-an-international-comparison-of-postlicensing-price-inflation
#9
Philip Savage, Sarah Mahmoud, Yogin Patel, Hagop Kantarjian
PURPOSE: The cost of cancer drugs forms a rising proportion of health care budgets worldwide. A number of studies have examined international comparisons of initial cost, but there is little work on postlicensing price increases. To examine this, we compared cancer drug prices at initial sale and subsequent price inflation in the United States and United Kingdom and also reviewed relevant price control mechanisms. METHODS: The 10 top-selling cancer drugs were selected, and their prices at initial launch and in 2015 were compared...
June 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28598891/effect-of-direct-to-consumer-advertising-dtca-on-statin-use-in-the-united-states
#10
Hsien-Yen Chang, Irene Murimi, Matthew Daubresse, Dima M Qato, Sherry L Emery, G Caleb Alexander
IMPORTANCE: The value of direct-to-consumer advertising (DTCA) of prescription drugs is widely debated, as is the effect of DTCA on prescription sales and health care utilization. OBJECTIVE: We examined the association between DTCA intensity for statin medications and prescription sales and cholesterol-related health care utilization. DESIGN, SETTING, AND PARTICIPANTS: We conducted an ecological study for 75 designated market areas from 2005 to 2009 in the United States using linked data regarding televised DTCA volume, non-DTCA marketing and promotion, retail, mail order and long-term care prescription drug sales, prescription drug and ambulatory care health care utilization, and contextual factors such as health care density and socioeconomic status...
June 8, 2017: Medical Care
https://www.readbyqxmd.com/read/28589268/e-cigarette-users-attitudes-on-the-banning-of-sales-of-nicotine-e-liquid-its-implication-on-e-cigarette-use-behaviours-and-alternative-sources-of-nicotine-e-liquid
#11
Li Ping Wong, Haridah Alias, Nasrin Agha Mohammadi, Azadeh Ghadimi, Victor Chee Wai Hoe
The banning of sales of nicotine e-liquid in e-cigarette shops has been implemented in several states in Malaysia. The distribution of nicotine e-liquid can only be allowed by licensed pharmacies or registered medical practitioners. This study aimed to evaluate e-cigarette users' responses to the control policy in a cross-sectional survey of 851 e-cigarette users by utilizing a self-report questionnaire that assessed (1) attitudes on regulation policy of e-cigarette banning; (2) e-cigarette use behaviors; and (3) sources of e-liquid after the regulation policy has been implemented...
June 6, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28588992/introducing-rapid-tests-for-malaria-into-the-retail-sector-what-are-the-unintended-consequences
#12
Eleanor Hutchinson, Coll Hutchison, Sham Lal, Kristian Hansen, Miriam Kayendeke, Christine Nabirye, Pascal Magnussen, Siân E Clarke, Anthony Mbonye, Clare I R Chandler
The observation that many people in Africa seek care for febrile illness in the retail sector has led to a number of public health initiatives to try to improve the quality of care provided in these settings. The potential to support the introduction of rapid diagnostic tests for malaria (mRDTs) into drug shops is coming under increased scrutiny. Those in favour argue that it enables the harmonisation of policy around testing and treatment for malaria and maintains a focus on market-based solutions to healthcare...
January 2017: BMJ Global Health
https://www.readbyqxmd.com/read/28574129/smoking-in-italy-in-2015-2016-prevalence-trends-roll-your-own-cigarettes-and-attitudes-towards-incoming-regulations
#13
Alessandra Lugo, Piergiorgio Zuccaro, Roberta Pacifici, Giuseppe Gorini, Paolo Colombo, Carlo La Vecchia, Silvano Gallus
PURPOSE: In 2016, a series of selective tobacco regulations, which did not affect tobacco price, came into force in Italy. To understand how Italians accepted the new norms, we analyzed data from our 2 most recent surveys among those we annually conduct on tobacco. METHODS: In 2015 and 2016, we conducted 2 representative cross-sectional studies focused on the new forthcoming tobacco legislation on a total sample of 6,046 Italians aged ≥15 years. RESULTS: Overall, 21...
May 26, 2017: Tumori
https://www.readbyqxmd.com/read/28568705/hair-analysis-for-the-detection-of-drug-use-is-there-potential-for-evasion
#14
Shanna Marrinan, Andres Roman-Urrestarazu, Declan Naughton, Emerlinda Levari, John Collins, Robert Chilcott, Giuseppe Bersani, Ornella Corazza
BACKGROUND: Hair analysis for illicit substances is widely used to detect chronic drug consumption or abstention from drugs. Testees are increasingly seeking ways to avoid detection by using a variety of untested adulterant products (e.g., shampoos, cleansers) widely sold online. This study aims to investigate adulteration of hair samples and to assess effectiveness of such methods. METHODS: The literature on hair test evasion was searched for on PubMed or MEDLINE, Psycinfo, and Google Scholar...
May 31, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28556310/variation-in-cannabis-potency-and-prices-in-a-newly-legal-market-evidence-from-30-million-cannabis-sales-in-washington-state
#15
Rosanna Smart, Jonathan P Caulkins, Beau Kilmer, Steven Davenport, Greg Midgette
AIMS: To (1) assess trends and variation in the market share of product types and potency sold in a legal cannabis retail market, and (2) estimate how potency and purchase quantity influence price variation for cannabis flower. DESIGN: Secondary analysis of publicly available data from Washington State's cannabis straceability system spanning July 7, 2014 to September 30, 2016. Descriptive statistics and linear regressions assessed variation and trends in cannabis product variety and potency...
May 27, 2017: Addiction
https://www.readbyqxmd.com/read/28551560/ornamental-plants-on-sale-to-the-public-are-a-significant-source-of-pesticide-residues-with-implications-for-the-health-of-pollinating-insects
#16
A Lentola, A David, A Abdul-Sada, A Tapparo, D Goulson, E M Hill
Garden centres frequently market nectar- and pollen-rich ornamental plants as "pollinator-friendly", however these plants are often treated with pesticides during their production. There is little information on the nature of pesticide residues present at the point of purchase and whether these plants may actually pose a threat to, rather than benefit, the health of pollinating insects. Using mass spectrometry analyses, this study screened leaves from 29 different 'bee-friendly' plants for 8 insecticides and 16 fungicides commonly used in ornamental production...
May 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28544367/the-diverging-trajectories-of-cannabis-and-tobacco-policies-in-the-united-states-reasons-and-possible-implications
#17
Wayne Hall, Lynn T Kozlowski
AIM: To examine briefly the (i) rationales for two policy proposals in the United States to make it mandatory for cigarettes to contain very low levels of nicotine and to legalize cannabis for recreational use by adults; and (ii) possible lessons that participants in each policy debate may learn from each other. METHOD: We briefly describe the diverging policies towards cannabis and tobacco in the United States, explain and critically analyse their rationales and discuss possible policy lessons...
May 22, 2017: Addiction
https://www.readbyqxmd.com/read/28542296/traders-guns-and-money-the-effects-of-mass-shootings-on-stock-prices-of-firearm-manufacturers-in-the-u-s
#18
Anandasivam Gopal, Brad N Greenwood
We investigate how mass shootings influence the stock price of firearms manufacturers. While it is well known that mass shootings lead to increased firearms sales, the response from financial markets is unclear. On one hand, given the observed short-term increase in demand, firearm stock prices may rise due to the unexpected financial windfall for the firm. On the other, mass shootings may result in calls for regulation of the industry, leading to divestment of firearms stocks in spite of short-term demand...
2017: PloS One
https://www.readbyqxmd.com/read/28527520/recent-advances-in-smart-biotechnology-hydrogels-and-nanocarriers-for-tailored-bioactive-molecules-depot
#19
REVIEW
Gesmi Milcovich, Stefania Lettieri, Filipe E Antunes, Bruno Medronho, Ana C Fonseca, Jorge F J Coelho, Paolo Marizza, Francesca Perrone, Rossella Farra, Barbara Dapas, Gabriele Grassi, Mario Grassi, Silvia Giordani
Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs...
May 9, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28522642/influence-of-drug-class-and-healthcare-setting-on-systemic-antifungal-expenditures-in-the-united-states-2005-15
#20
Margaret A Fitzpatrick, Katie J Suda, Charlesnika T Evans, Robert J Hunkler, Frances Weaver, Glen T Schumock
PURPOSE: Overall and specific class trends in systemic antifungal expenditures in various U.S. healthcare settings from 2005 through 2015 were evaluated. METHODS: Systemic antifungal expenditures from January 1, 2005, through December 31, 2015, were obtained from the QuintilesIMS National Sales Perspective database, which provides a statistically valid projection of medication purchases from multiple markets throughout the United States. Summary data for total antifungal expenditures over the entire period are reported, as are growth and the percentage change in expenditures from one year to the next...
May 18, 2017: American Journal of Health-system Pharmacy: AJHP
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