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https://www.readbyqxmd.com/read/27909733/nitrogen-gas-plasma-treatment-of-bacterial-spores-induces-oxidative-stress-that-damages-the-genomic-dna
#1
Akikazu Sakudo, Yoichi Toyokawa, Tetsuji Nakamura, Yoshihito Yagyu, Yuichiro Imanishi
Gas plasma, produced by a short high‑voltage pulse generated from a static induction thyristor power supply [1.5 kilo pulse/sec (kpps)], was demonstrated to inactivate Geobacillus stearothermophilus spores (decimal reduction time at 15 min, 2.48 min). Quantitative polymerase chain reaction and enzyme‑linked immunosorbent assays further indicated that nitrogen gas plasma treatment for 15 min decreased the level of intact genomic DNA and increased the level of 8-hydroxy-2'-deoxyguanosine, a major product of DNA oxidation...
November 29, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27903410/long-chain-n-3-pufa-supplied-by-the-usual-diet-decrease-plasma-stearoyl-coa-desaturase-index-in-non-hypertriglyceridemic-older-adults-at-high-vascular-risk
#2
Ana M Pérez-Heras, Jordi Mayneris-Perxachs, Montserrat Cofán, Mercè Serra-Mir, Ana I Castellote, Carmen López-Sabater, Montserrat Fitó, Jordi Salas-Salvadó, Miguel-Ángel Martínez-González, Dolores Corella, Ramon Estruch, Emilio Ros, Aleix Sala-Vila
BACKGROUND & AIMS: The activity of stearoyl-CoA desaturase-1 (SCD1), the central enzyme in the synthesis of monounsaturated fatty acids (MUFA), has been associated with de novo lipogenesis. In experimental models SCD1 is down-regulated by polyunsaturated fatty acids (PUFA), but clinical studies are scarce. The effect of long-chain n-3 PUFA (LCn-3PUFA) supplied by the regular diet, in the absence of fatty fish or fish oil supplementation, remains to be explored. METHODS: We related 1-y changes in plasma SCD1 index, as assessed by the C16:1n-7/C16:0 ratio, to both adiposity traits and nutrient intake changes in a sub-cohort (n = 243) of non-hypertriglyceridemic subjects of the PREDIMED (PREvención con DIeta MEDiterranea) trial...
November 19, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27901131/porous-silicon-based-biosensors-towards-real-time-optical-detection-of-target-bacteria-in-the-food-industry
#3
Naama Massad-Ivanir, Giorgi Shtenberg, Nitzan Raz, Christel Gazenbeek, Dries Budding, Martine P Bos, Ester Segal
Rapid detection of target bacteria is crucial to provide a safe food supply and to prevent foodborne diseases. Herein, we present an optical biosensor for identification and quantification of Escherichia coli (E. coli, used as a model indicator bacteria species) in complex food industry process water. The biosensor is based on a nanostructured, oxidized porous silicon (PSi) thin film which is functionalized with specific antibodies against E. coli. The biosensors were exposed to water samples collected directly from process lines of fresh-cut produce and their reflectivity spectra were collected in real time...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27901036/the-effects-of-policy-actions-to-improve-population-dietary-patterns-and-prevent-diet-related-non-communicable-diseases-scoping-review
#4
REVIEW
L Hyseni, M Atkinson, H Bromley, L Orton, F Lloyd-Williams, R McGill, S Capewell
Poor diet generates a bigger non-communicable disease (NCD) burden than tobacco, alcohol and physical inactivity combined. We reviewed the potential effectiveness of policy actions to improve healthy food consumption and thus prevent NCDs. This scoping review focused on systematic and non-systematic reviews and categorised data using a seven-part framework: price, promotion, provision, composition, labelling, supply chain, trade/investment and multi-component interventions. We screened 1805 candidate publications and included 58 systematic and non-systematic reviews...
November 30, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27895203/a-palmitic-acid-elongase-affects-eicosapentaenoic-acid-and-plastidal-monogalactosyldiacylglcerol-levels-in-nannochloropsis
#5
Lina Juana Dolch, Camille Rak, Giorgio Perin, Guillaume Tourcier, Richard Broughton, Marina Leterrier, Tomas Morosinotto, Frédérique Tellier, Jean-Denis Faure, Denis Falconet, Juliette Jouhet, Olga Sayanova, Frederic Beaudoin, Eric Marechal
Nannochloropsis species are oleaginous eukaryotes containing a plastid limited by four membranes, deriving from a secondary endosymbiosis. In Nannochloropsis, thylakoid lipids including monogalactosyldiacylglycerol (MGDG) are enriched in eicosapentaenoic acid (EPA). The need for EPA in MGDG is not understood. Fatty acids are de novo synthesized in the stroma, then converted into very-long-chain polyunsaturated fatty acids at the ER. The production of MGDG relies therefore on an EPA supply from the ER to the plastid, following an unknown process...
November 28, 2016: Plant Physiology
https://www.readbyqxmd.com/read/27887832/perfluoroalkyl-acids-pfaas-in-the-pra-and-kakum-river-basins-and-associated-tap-water-in-ghana
#6
David K Essumang, Albert Eshun, Jonathan N Hogarh, John K Bentum, Joseph K Adjei, Junya Negishi, Shihori Nakamichi, Md Habibullah-Al-Mamun, Shigeki Masunaga
Perfluoroalkyl acids (PFAAs) are persistent environmental pollutants that have been detected in various media including human serum. Due to concerns regarding their bioaccumulation and possible negative health effects, an understanding of routes of human exposure is necessary. PFAAs are recalcitrant in many water treatment processes, making drinking water a potential source of human exposure. This study presents the first report on contamination from PFAAs in river and drinking water in Ghana. The targeted PFAAs were perfluoroalkyl carboxylic acids (PFCAs) with C4-14 carbon chain and perfluoroalkane sulphonic acids (PFSAs) with C6, 8, 10...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27886782/ensuring-patient-centered-access-to-cardiovascular-disease-medicines-in-low-income-and-middle-income-countries-through-health-system-strengthening
#7
REVIEW
Dan N Tran, Benson Njuguna, Timothy Mercer, Imran Manji, Lydia Fischer, Marya Lieberman, Sonak D Pastakia
Cardiovascular disease (CVD) is the leading cause of global mortality and is expected to reach 23 million deaths by 2030. Eighty percent of CVD deaths occur in low-income and middle-income countries (LMICs). Although CVD prevention and treatment guidelines are available, translating these into practice is hampered in LMICs by inadequate health care systems that limit access to lifesaving medications. In this review article, we describe the deficiencies in the current LMIC supply chains that limit access to effective CVD medicines, and discuss existing solutions that are translatable to similar settings so as to address these deficiencies...
February 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/27884478/vaccine-provision-delivering-sustained-widespread-use
#8
Scott Preiss, Nathalie Garçon, Anthony L Cunningham, Richard Strugnell, Leonard R Friedland
The administration of a vaccine to a recipient is the final step in a development and production process that may have begun several decades earlier. Here we describe the scale and complexity of the processes that brings a candidate vaccine through clinical development to the recipient. These challenges include ensuring vaccine quality (between 100 and 500 different Quality Control tests are performed during production to continually assess safety, potency and purity); making decisions about optimal vaccine presentation (pre-filled syringes versus multi-dose vials) that affect capacity and supply; and the importance of maintaining the vaccine cold chain (most vaccines have stringent storage temperature requirements necessary to maintain activity and potency)...
November 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27884477/map-of-different-vaccine-supply-chain-efficiency-measures
#9
Leila A Haidari, Shawn T Brown, Patrick Wedlock, Bruce Y Lee
No abstract text is available yet for this article.
November 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27880749/early-diagnosis-of-hiv-infection-in-infants-one-caribbean-and-six-sub-saharan-african-countries-2011-2015
#10
Karidia Diallo, Andrea A Kim, Shirley Lecher, Dennis Ellenberger, R Suzanne Beard, Helen Dale, Mackenzie Hurlston, Molly Rivadeneira, Peter N Fonjungo, Laura N Broyles, Guoqing Zhang, Katrina Sleeman, Shon Nguyen, Steve Jadczak, Nadine Abiola, Raimi Ewetola, Jérémie Muwonga, Franck Fwamba, Christina Mwangi, Mary Naluguza, Charles Kiyaga, Isaac Ssewanyana, Deyde Varough, Domercant Wysler, David Lowrance, Frantz Jean Louis, Olbeg Desinor, Josiane Buteau, Francois Kesner, Vanessa Rouzier, Nat Segaren, Tessa Lewis, Abdoulaye Sarr, Geoffrey Chipungu, Sundeep Gupta, Daniel Singer, Reuben Mwenda, Hilary Kapoteza, Zawadi Chipeta, Nancy Knight, Sergio Carmona, William MacLeod, Gayle Sherman, Yogan Pillay, Clement B Ndongmo, Bridget Mugisa, Annie Mwila, James McAuley, Peter J Chipimo, Wezi Kaonga, Dailess Nsofwa, Davy Nsama, Fales Zulu Mwamba, Crispin Moyo, Clement Phiri, Marie-Yolande Borget, Leonard Ya-Kouadio, Abo Kouame, Christiane A Adje-Toure, John Nkengasong
Pediatric human immunodeficiency virus (HIV) infection remains an important public health issue in resource-limited settings. In 2015, 1.4 million children aged <15 years were estimated to be living with HIV (including 170,000 infants born in 2015), with the vast majority living in sub-Saharan Africa (1). In 2014, 150,000 children died from HIV-related causes worldwide (2). Access to timely HIV diagnosis and treatment for HIV-infected infants reduces HIV-associated mortality, which is approximately 50% by age 2 years without treatment (3)...
November 25, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27876164/measuring-the-environmental-sustainability-performance-of-global-supply-chains-a-multi-regional-input-output-analysis-for-carbon-sulphur-oxide-and-water-footprints
#11
Adolf Acquaye, Kuishuang Feng, Eunice Oppon, Said Salhi, Taofeeq Ibn-Mohammed, Andrea Genovese, Klaus Hubacek
Measuring the performance of environmentally sustainable supply chains instead of chain constitute has become a challenge despite the convergence of the underlining principles of sustainable supply chain management. This challenge is exacerbated by the fact that supply chains are inherently dynamic and complex and also because multiple measures can be used to characterize performances. By identifying some of the critical issues in the literature regarding performance measurements, this paper contributes to the existing body of literature by adopting an environmental performance measurement approach for economic sectors...
November 18, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27873475/2-7-octanedione-and-2-5-dimethyladipic-acid-from-the-electrochemical-coupling-of-biomass-derived-carboxylic-acids-c8-platforms-for-renewable-polymers-and-fuels
#12
Linglin Wu, Mark Mascal, Thomas Farmer, Sacha Pérocheau Arnaud, Maria Angelica Wong Chang
Electrolysis of biomass-derived carbonyl compounds is an alternative to condensation chemistry for supplying products with chain length >C6 for biofuel and renewable material production. Kolbe coupling of biomass-derived levulinic acid gives 2,7-octanedione, a new platform molecule only two low process-intensity steps removed from raw biomass. Hydrogenation to 2,7-octanediol provides a chiral secondary diol largely unknown to polymer chemistry, while intramolecular aldol condensation followed by hydrogenation yields branched cycloalkanes suitable for use as high-octane, cellulosic gasoline...
November 21, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27873132/mechanisms-of-excessive-extracellular-glutamate-accumulation-in-temporal-lobe-epilepsy
#13
Jan Albrecht, Magdalena Zielińska
There is compelling evidence that initiation and maintenance of epileptic seizures in temporal lobe epilepsy (TLE) is facilitated by excessive accumulation in the extracellular (perisynaptic) space of the excitatory neurotransmitter glutamate (Glu). This review discusses the mechanisms underlying this phenomenon. Glu released from neurons is taken up by astrocytes and activated there by glutamine synthetase (GS) to form glutamine (Gln) which upon entry to neurons is degraded back to Glu by phosphate-activated glutaminase (PAG): this chain of reactions has been defined as the glutamine/glutamate/cycle (GGC)...
November 21, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27871132/aspergillus-penicillioides-differentiation-and-cell-division-at-0-585-water-activity
#14
Andrew Stevenson, Philip G Hamill, Callum J O'Kane, Gerhard Kminek, John D Rummel, Mary A Voytek, Jan Dijksterhuis, John E Hallsworth
Water availability acts as the most-stringent constraint for life on Earth. Thus, understanding the water relations of microbial extremophiles is imperative to our ability to increase agricultural productivity (e.g., by enhancing the processing and turnover of dead organic matter in soils of arid regions); reduce human exposure to mycotoxins in buildings and our food-supply chain; prevent the spoilage of foods/animal feeds, books, museum specimens and artworks; and better control microbiology of industrial fermentations...
November 21, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27867504/short-rotation-plantations-policy-history-in-europe-lessons-from-the-past-and-recommendations-for-the-future
#15
REVIEW
Kevin N Lindegaard, Paul W R Adams, Martin Holley, Annette Lamley, Annika Henriksson, Stig Larsson, Hans-Georg von Engelbrechten, Gonzalo Esteban Lopez, Marcin Pisarek
Short rotation plantations (SRPs) are fast-growing trees (such as willow (Salix spp.), poplar (Populus spp.) and Eucalyptus) grown closely together and harvested in periods of 2-20 years. There are around 50,000 hectares of SRPs in Europe, a relatively small area considering that there have been supportive policy measures in many countries for 30 years. This paper looks at the effect that the policy measures used in different EU countries have had, and how other external factors have impacted on the development of the industry...
August 2016: Food and energy security
https://www.readbyqxmd.com/read/27864726/hand-assisted-laparoscopic-right-hemicolectomy-with-complete-mesocolic-excision-and-central-vascular-ligation-a-novel-technique-for-right-colon-cancer
#16
Qing-Bin Wu, Xiang-Bing Deng, Xu-Yang Yang, Bing-Chen Chen, Wan-Bin He, Tao Hu, Ming-Tian Wei, Zi-Qiang Wang
BACKGROUND: It can be difficult to locate the superior mesenteric vein and dissect around middle colic vessels during laparoscopic right hemicolectomy with complete mesocolon excision due to a high rate of vascular variations in the superior mesenteric vessels. Therefore, we report a modified technique for hand-assisted laparoscopic right hemicolectomy with complete mesocolic excision and central vascular ligation, which addresses these two problems. METHODS: Thirty-one consecutive patients with right colon cancer underwent this procedure from March 2014 to August 2015...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27863004/local-versus-offshore-production-of-ready-to-use-therapeutic-foods-and-small-quantity-lipid-based-nutrient-supplements
#17
Joel Segrè, Grace Liu, Jan Komrska
Manufacturers on four continents currently produce ready-to-use therapeutic foods (RUTF). Some produce locally, near their intended users, while others produce offshore and ship their product long distances. Small quantity lipid-based nutrient supplements (SQ-LNS) such as Nutriset's Enov'Nutributter are not yet in widespread production. There has been speculation whether RUTF and SQ-LNS should be produced primarily offshore, locally, or both. We analyzed The United Nations Children's Fund (UNICEF) Supply Division data, reviewed published literature, and interviewed local manufacturers to identify key benefits and challenges to local versus offshore manufacture of RUTF...
November 8, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27853671/heparanase-inhibitors-facilitate-the-assembly-of-the-basement-membrane-in-artificial-skin
#18
Makoto Tsunenaga
Recent research suggests that the basement membrane at the dermal-epidermal junction of the skin plays an important role in maintaining a healthy epidermis and dermis, and repeated damage to the skin can destabilize the skin and accelerate the aging process. Skin-equivalent models are suitable for studying the reconstruction of the basement membrane and its contribution to epidermal homeostasis because they lack the basement membrane and show abnormal expression of epidermal differentiation markers. By using these models, it has been shown that reconstruction of the basement membrane is enhanced not only by supplying basement membrane components, but also by inhibiting proteinases such as urokinase and matrix metalloproteinase...
August 2016: Current Tissue Engineering
https://www.readbyqxmd.com/read/27853605/closing-oil-palm-yield-gaps-among-indonesian-smallholders-through-industry-schemes-pruning-weeding-and-improved-seeds
#19
T Soliman, F K S Lim, J S H Lee, L R Carrasco
Oil palm production has led to large losses of valuable habitats for tropical biodiversity. Sparing of land for nature could in theory be attained if oil palm yields increased. The efficiency of oil palm smallholders is below its potential capacity, but the factors determining efficiency are poorly understood. We employed a two-stage data envelopment analysis approach to assess the influence of agronomic, supply chain and management factors on oil palm production efficiency in 190 smallholders in six villages in Indonesia...
August 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27849573/life-cycle-greenhouse-gas-emissions-and-freshwater-consumption-associated-with-bakken-tight-oil
#20
Ian J Laurenzi, Joule A Bergerson, Kavan Motazedi
In recent years, hydraulic fracturing and horizontal drilling have been applied to extract crude oil from tight reservoirs, including the Bakken formation. There is growing interest in understanding the greenhouse gas (GHG) emissions associated with the development of tight oil. We conducted a life cycle assessment of Bakken crude using data from operations throughout the supply chain, including drilling and completion, refining, and use of refined products. If associated gas is gathered throughout the Bakken well life cycle, then the well to wheel GHG emissions are estimated to be 89 g CO2eq/MJ (80% CI, 87-94) of Bakken-derived gasoline and 90 g CO2eq/MJ (80% CI, 88-94) of diesel...
November 14, 2016: Proceedings of the National Academy of Sciences of the United States of America
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