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https://www.readbyqxmd.com/read/28227582/reconfigurable-analog-classifier-for-knee-joint-rehabilitation
#1
Sahil Shah, Hakan Toreyin, Omer T Inan, Jennifer Hasler, Sahil Shah, Hakan Toreyin, Omer T Inan, Jennifer Hasler, Sahil Shah, Jennifer Hasler, Omer T Inan, Hakan Toreyin
We present a System-On-Chip Field Programmable Analog Array (FPAA) for analyzing and processing the signals off an accelerometer for a wearable joint health assessment device. FPAAs have been shown to compute with an efficiency of 1000 times, as well as area efficiencies of 100 times, more than digital solutions. This work presents a low power signal processing system which allows us to extract features from the output of the accelerometer. These features are used by the classifier, implemented using a vector matrix multiplication and a two output 1-winner-take-all, to detect flexion and extension cycles in the subject...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221979/influence-of-transportation-conditions-and-postharvest-disinfection-treatments-on-microbiological-quality-of-fresh-market-tomatoes-cv-nemo-netta-in-a-south-african-supply-chain
#2
M S Sibomana, L W Ziena, S Schmidt, T S Workneh
Postharvest microbial spoilage due to suboptimal transportation and packaging conditions is a key concern for the South African tomato industry. This study investigated the influence of washing with tap water or aqueous disinfectant solutions (chlorinated and anolyte water) on the microbiological quality of tomatoes during storage after transportation in nonrefrigerated trucks along two supply routes when packaged in crates and boxes. Route 1 was 1,093 km from field to storage site, while route 2 was 1,057 km...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221978/quantitative-microbial-risk-assessment-for-escherichia-coli-o157-h7-in-fresh-cut-lettuce
#3
Hao Pang, Elisabetta Lambertini, Robert L Buchanan, Donald W Schaffner, Abani K Pradhan
Leafy green vegetables, including lettuce, are recognized as potential vehicles for foodborne pathogens such as Escherichia coli O157:H7. Fresh-cut lettuce is potentially at high risk of causing foodborne illnesses, as it is generally consumed without cooking. Quantitative microbial risk assessments (QMRAs) are gaining more attention as an effective tool to assess and control potential risks associated with foodborne pathogens. This study developed a QMRA model for E. coli O157:H7 in fresh-cut lettuce and evaluated the effects of different potential intervention strategies on the reduction of public health risks...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28218221/gene-expressions-underlying-mishandled-calcium-clearance-and-elevated-generation-of-reactive-oxygen-species-in-the-coronary-artery-smooth-muscle-cells-of-chronic-heart-failure-rats
#4
Liang Ding, Xian-Xiu Su, Wen-Hui Zhang, Yu-Xiang Xu, Xue-Feng Pan
BACKGROUND: The calcium clearance and reactive oxygen species (ROS) generations in the coronary artery smooth muscle cells in chronic heart failure (HF) have not been fully investigated. Therefore, we attempted to understand the gene expressions underlying the mishandling of calcium clearance and the accumulations of ROS. METHODS: We initially established an animal model of chronic HF by making the left anterior descending coronary artery ligation (CAL) in rats, and then isolated the coronary artery vascular smooth muscle cells from the ischemic and the nonischemic parts of the coronary artery vessels in 12 weeks after CAL operation...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28215168/contributions-of-the-interaction-between-dietary-protein-and-gut-microbiota-to-intestinal-health
#5
Ning Ma, Yanan Tian, Yi Wu, Xi Ma
There is growing recognition that composition and metabolic activity of the gut microbiota can be modulated by the dietary proteins which in turn impact health. The amino acid composition and digestibility of proteins, which are influenced by its source and amount of intake, play a pivotal role in determining the microbiota. Reciprocally, it appears that the gut microbiota is also able to affect protein metabolism which give rise to the view that function between the microbiota and protein can proceed in both directions...
February 16, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28208132/an-outbreak-of-acute-hepatitis-caused-by-genotype-ib-hepatitis-a-viruses-contaminating-the-water-supply-in-thailand
#6
Kriangsak Ruchusatsawat, Jongkonnee Wongpiyabovorn, Chonthicha Kawidam, Laddawan Thiemsing, Somchai Sangkitporn, Sayaka Yoshizaki, Masashi Tatsumi, Naokazu Takeda, Koji Ishii
BACKGROUND: In 2000, an outbreak of acute hepatitis A was reported in a province adjacent to Bangkok, Thailand. AIMS: To investigate the cause of the 2000 hepatitis A outbreaks in Thailand using molecular epidemiological analysis. METHODS: Serum and stool specimens were collected from patients who were clinically diagnosed with acute viral hepatitis. Water samples from drinking water and deep-drilled wells were also collected. These specimens were subjected to polymerase chain reaction (PCR) amplification and sequencing of the VP1/2A region of the hepatitis A virus (HAV) genome...
February 17, 2017: Intervirology
https://www.readbyqxmd.com/read/28205599/network-growth-models-a-behavioural-basis-for-attachment-proportional-to-fitness
#7
Michael Bell, Supun Perera, Mahendrarajah Piraveenan, Michiel Bliemer, Tanya Latty, Chris Reid
Several growth models have been proposed in the literature for scale-free complex networks, with a range of fitness-based attachment models gaining prominence recently. However, the processes by which such fitness-based attachment behaviour can arise are less well understood, making it difficult to compare the relative merits of such models. This paper analyses an evolutionary mechanism that would give rise to a fitness-based attachment process. In particular, it is proven by analytical and numerical methods that in homogeneous networks, the minimisation of maximum exposure to node unfitness leads to attachment probabilities that are proportional to node fitness...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197190/electroacupuncture-induces-acute-changes-in-cerebral-cortical-mirna-profile-improves-cerebral-blood-flow-and-alleviates-neurological-deficits-in-a-rat-model-of-stroke
#8
Hai-Zhen Zheng, Wei Jiang, Xiao-Feng Zhao, Jing Du, Pan-Gong Liu, Li-Dan Chang, Wen-Bo Li, Han-Tong Hu, Xue-Min Shi
Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters miRNA expression in the cortex. In this study, we examined changes in the cerebral cortical miRNA profile, cerebral blood flow and neurological function induced by electroacupuncture in a rat model of stroke. Electroacupuncture was performed at Renzhong (GV26) and Neiguan (PC6), with a frequency of 2 Hz, continuous wave, current intensity of 3.0 mA, and stimulation time of 1 minute...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28195008/packaging-waste-prevention-in-the-distribution-of-fruit-and-vegetables-an-assessment-based-on-the-life-cycle-perspective
#9
Camilla Tua, Simone Nessi, Lucia Rigamonti, Giovanni Dolci, Mario Grosso
In recent years, alternative food supply chains based on short distance production and delivery have been promoted as being more environmentally friendly than those applied by the traditional retailing system. An example is the supply of seasonal and possibly locally grown fruit and vegetables directly to customers inside a returnable crate (the so-called 'box scheme'). In addition to other claimed environmental and economic advantages, the box scheme is often listed among the packaging waste prevention measures...
February 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28193863/modular-electron-transport-chains-from-eukaryotic-organelles-function-to-support-nitrogenase-activity
#10
Jianguo Yang, Xiaqing Xie, Mingxuan Yang, Ray Dixon, Yi-Ping Wang
A large number of genes are necessary for the biosynthesis and activity of the enzyme nitrogenase to carry out the process of biological nitrogen fixation (BNF), which requires large amounts of ATP and reducing power. The multiplicity of the genes involved, the oxygen sensitivity of nitrogenase, plus the demand for energy and reducing power, are thought to be major obstacles to engineering BNF into cereal crops. Genes required for nitrogen fixation can be considered as three functional modules encoding electron-transport components (ETCs), proteins required for metal cluster biosynthesis, and the "core" nitrogenase apoenzyme, respectively...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28193721/women-s-limited-choice-and-availability-of-modern-contraception-at-retail-outlets-and-public-sector-facilities-in-luanda-angola-2012-2015
#11
Benjamin Nieto-Andrade, Eva Fidel, Rebecca Simmons, Dana Sievers, Anya Fedorova, Suzanne Bell, Karen Weidert, Ndola Prata
In Angola, many women want to use family planning but lack access to affordable and preferred methods. This article assesses the link between women's choice and availability of contraceptive methods in Luanda, Angola, drawing on data from 3 surveys: a 2012 survey among women ages 15-49 and 2 retail surveys conducted in 2014 and 2015 among outlets and facilities offering contraceptive methods. Descriptive statistics for women's contraceptive knowledge, use, and preferred methods were stratified by age group...
February 13, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28179229/exogenous-amino-acids-suppress-glucose-oxidation-and-potentiate-hepatic-glucose-production-in-late-gestation-fetal-sheep
#12
Laura D Brown, Jaden R Kohn, Paul J Rozance, William W Hay, Stephanie R Wesolowski
Acute amino acid (AA) infusion increases AA oxidation rates in normal late gestation fetal sheep. Because fetal oxygen consumption rate does not change with increased AA oxidation, we hypothesized that AA infusion would suppress glucose oxidation pathways and that the additional carbon supply from AA would activate hepatic glucose production. To test this, late gestation fetal sheep were infused intravenously for 3h with saline or exogenous AA (AA). Glucose tracer metabolic studies were performed and skeletal muscle and liver tissues samples were collected...
February 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28178891/up-regulation-of-cerebral-cytochrome-c-oxidase-and-hemodynamics-by-transcranial-infrared-laser-stimulation-a-broadband-near-infrared-spectroscopy-study
#13
Xinlong Wang, Fenghua Tian, Divya D Reddy, Sahil S Nalawade, Douglas W Barrett, Francisco Gonzalez-Lima, Hanli Liu
Transcranial infrared laser stimulation (TILS) is a noninvasive form of brain photobiomulation. Cytochrome-c-oxidase (CCO), the terminal enzyme in the mitochondrial electron transport chain, is hypothesized to be the primary intracellular photoacceptor. We hypothesized that TILS up-regulates cerebral CCO and causes hemodynamic changes. We delivered 1064-nm laser stimulation to the forehead of healthy participants ( n = 11), while broadband near-infrared spectroscopy was utilized to acquire light reflectance from the TILS-treated cortical region before, during, and after TILS...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28178186/exogenous-pthrp-repairs-the-damaged-fracture-healing-of-pthrp-mice-and-accelerates-fracture-healing-of-wild-mice
#14
Yinhe Wang, Xin Fang, Chun Wang, Congzhu Ding, Hua Lin, Anlong Liu, Lei Wang, Yang Cao
Bone fracture healing is a complicated physiological regenerative process initiated in response to injury and is similar to bone development. To demonstrate whether an exogenous supply of parathyroid hormone-related protein (PTHrP) helps in bone fracture healing, closed mid-diaphyseal femur fractures were created and stabilized with intramedullary pins in eight-week-old wild-type (WT) PTHrP+/+ and PTHrP+/- mice. After administering PTHrP for two weeks, callus tissue properties were analyzed at one, two, and four weeks post-fracture (PF) by various methods...
February 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28177707/dietary-fish-oil-delays-hypoxic-skeletal-muscle-fatigue-and-enhances-caffeine-stimulated-contractile-recovery-in-the-rat-in-vivo-hindlimb
#15
Gregory E Peoples, Peter L McLennan
Oxygen efficiency influences skeletal muscle contractile function during physiological hypoxia. Dietary fish oil, providing docosahexaenoic acid (DHA), reduces the oxygen cost of muscle contraction. This study used autologous perfused rat hindlimb model to examine the effects of a fish oil diet on skeletal muscle fatigue during an acute hypoxic challenge. Male Wistar rats were fed a diet rich in saturated fat (SF), long chain (LC) n-6 polyunsaturated fatty acids (n-6 PUFA), or LC n-3 PUFA DHA from fish oil (FO) (8weeks)...
January 26, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28174083/medium-chain-length-polyhydroxyalkanoates-biosynthesis-in-pseudomonas-putida-mt-2-is-enhanced-by-co-metabolism-of-glycerol-octanoate-or-fatty-acids-mixtures
#16
Paul Fontaine, Ridha Mosrati, David Corroler
The synthesis of medium chain length polyhydroxyalkanoates (mcl-PHAs) by Pseudomonas putida mt-2 was investigated under nitrogen-rich then deficient conditions with glycerol/octanoate or long-chain fatty acids (LCFAs) as carbon sources. When mixed, glycerol and octanoate were co-assimilated regardless of nitrogen availability but provided that glycerol uptake has been already triggered under non-limiting nutrient conditions. This concomitant consumption allowed to enhance mcl-PHAs accumulation (up to 57% of cell dry weight (CDW)) under both non-limiting and nitrogen deficient conditions...
February 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28170255/dissolution-and-metastable-solution-of-cellulose-in-naoh-thiourea-at-8-%C3%A2-c-for-construction-of-nanofibers
#17
Zhiwei Jiang, Yan Fang, Yan-Ping Ma, Maili Liu, Ruigang Liu, Hongxia Guo, Ang Lu, Lina Zhang
To develop the facile approach for the cellulose dissolution, a novel solvent (9.3 wt% NaOH/7.4 wt% thiourea aqueous solution) was used, for the first time, to dissolve cellulose within 5 min at 8 °C. The results of nuclear magnetic resonance (NMR) and Raman spectra demonstrated that stable thiourea···OH(-) complexes formed through strong hydrogen bonds in NaOH/thiourea at room temperature. Moreover, the strength of the hydrogen bonds of thioureaOH complexes was much stronger than that of urea···OH(-) complexes, and the number of thiourea···OH(-) complexes increased significantly in 9...
February 7, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28168597/the-role-of-nutritional-supplements-in-the-treatment-of-adhd-what-the-evidence-says
#18
REVIEW
Klaus W Lange, Joachim Hauser, Katharina M Lange, Ewelina Makulska-Gertruda, Yukiko Nakamura, Andreas Reissmann, Yuko Sakaue, Tomoyuki Takano, Yoshihiro Takeuchi
Attention-deficit hyperactivity disorder (ADHD) is a common behavioral disorder in children and adolescents and may persist into adulthood. Insufficient nutritional supply of long-chain polyunsaturated fatty acids (LC-PUFAs) and other components including various minerals has been suggested to play a role in the development of ADHD symptoms. This review presents the evidence regarding the role of nutritional PUFA, zinc, iron, and magnesium supplements in the treatment of ADHD with a focus on the critical evaluation of the relevant literature published from 2014 to April 2016...
February 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28167241/the-effect-of-sunitinib-treatment-in-human-melanoma-xenografts-associations-with-angiogenic-profiles
#19
Jon-Vidar Gaustad, Trude G Simonsen, Lise Mari K Andersen, Einar K Rofstad
The effect of antiangiogenic agents targeting the vascular endothelial growth factor A (VEGF-A) pathway has been reported to vary substantially in preclinical studies. The purpose of this study was to investigate the effect of sunitinib treatment on tumor vasculature and oxygenation in melanoma xenografts with different angiogenic profiles. A-07, U-25, D-12, or R-18 melanoma xenografts were grown in dorsal window chambers and given daily treatments of sunitinib (40 mg/kg) or vehicle. Morphologic parameters of tumor vascular networks were assessed from high-resolution transillumination images, and tumor blood supply times (BSTs) were assessed from first-pass imaging movies...
February 2, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28164303/process-mining-is-an-underutilized-clinical-research-tool-in-transfusion-medicine
#20
Jason G Quinn, David M Conrad, Calvino K Cheng
BACKGROUND: To understand inventory performance, transfusion services commonly use key performance indicators (KPIs) as summary descriptors of inventory efficiency that are graphed, trended, and used to benchmark institutions. STUDY DESIGN AND METHODS: Here, we summarize current limitations in KPI-based evaluation of blood bank inventory efficiency and propose process mining as an ideal methodology for application to inventory management research to improve inventory flows and performance...
February 5, 2017: Transfusion
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