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https://www.readbyqxmd.com/read/29677636/aunp-rf-sensor-an-innovative-application-of-rf-technology-for-sensing-pathogens-electrically-in-liquids-spel-within-the-food-supply-chain
#1
Leann Lerie Matta, Saranraj Karuppuswami, Premjeet Chahal, Evangelyn C Alocilja
Rapid detection techniques of pathogenic bacteria in the liquid food supply chain are of significant research interest due to their pivotal role in preventing foodborne outbreaks, and in maintaining high standards of public health and safety. Milk and dairy products are of particular interest due to their widespread consumption across the globe. In this paper, a biosensor for detecting pathogenic bacteria in milk using dextrin-capped gold nanoparticles (d-AuNP) as labels decoded at microwave frequencies is presented...
April 11, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29677551/growth-detection-and-virulence-of-listeria-monocytogenes-in-the-presence-of-other-microorganisms-microbial-interactions-from-species-to-strain-level
#2
REVIEW
Evangelia A Zilelidou, Panagiotis N Skandamis
Like with all food microorganisms, many basic aspects of L. monocytogenes life are likely to be influenced by its interactions with bacteria living in close proximity. This pathogenic bacterium is a major concern both for the food industry and health organizations since it is ubiquitous and able to withstand harsh environmental conditions. Due to the ubiquity of Listeria monocytogenes, various strains may contaminate foods at different stages of the supply chain. Consequently, simultaneous exposure of consumers to multiple strains is also possible...
April 12, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29673223/patchoulol-production-with-metabolically-engineered-corynebacterium-glutamicum
#3
Nadja A Henke, Julian Wichmann, Thomas Baier, Jonas Frohwitter, Kyle J Lauersen, Joe M Risse, Petra Peters-Wendisch, Olaf Kruse, Volker F Wendisch
Patchoulol is a sesquiterpene alcohol and an important natural product for the perfume industry. Corynebacterium glutamicum is the prominent host for the fermentative production of amino acids with an average annual production volume of ~6 million tons. Due to its robustness and well established large-scale fermentation, C. glutamicum has been engineered for the production of a number of value-added compounds including terpenoids. Both C40 and C50 carotenoids, including the industrially relevant astaxanthin, and short-chain terpenes such as the sesquiterpene valencene can be produced with this organism...
April 17, 2018: Genes
https://www.readbyqxmd.com/read/29670594/cellular-and-molecular-responses-of-dunaliella-tertiolecta-by-expression-of-a-plant-medium-chain-length-fatty-acid-specific-acyl-acp-thioesterase
#4
Huixin Lin, Hui Shen, Yuan K Lee
Metabolic engineering of microalgae to accumulate high levels of medium chain length fatty acids (MCFAs) has met with limited success. Traditional approaches employ single introduction of MCFA specific acyl-ACP thioesterases (TEs), but our current research in transgenic Dunaliella tertiolecta line has highlighted that, there is no single rate-limiting approach that can effectively increase MCFA levels. Here, we explore the accumulation of MCFAs in D. tertiolecta after transgenic expression of myristic acid biased TE (C14TE)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29670262/integrating-photonics-with-silicon-nanoelectronics-for-the-next-generation-of-systems-on-a-chip
#5
Amir H Atabaki, Sajjad Moazeni, Fabio Pavanello, Hayk Gevorgyan, Jelena Notaros, Luca Alloatti, Mark T Wade, Chen Sun, Seth A Kruger, Huaiyu Meng, Kenaish Al Qubaisi, Imbert Wang, Bohan Zhang, Anatol Khilo, Christopher V Baiocco, Miloš A Popović, Vladimir M Stojanović, Rajeev J Ram
Electronic and photonic technologies have transformed our lives-from computing and mobile devices, to information technology and the internet. Our future demands in these fields require innovation in each technology separately, but also depend on our ability to harness their complementary physics through integrated solutions1,2 . This goal is hindered by the fact that most silicon nanotechnologies-which enable our processors, computer memory, communications chips and image sensors-rely on bulk silicon substrates, a cost-effective solution with an abundant supply chain, but with substantial limitations for the integration of photonic functions...
April 2018: Nature
https://www.readbyqxmd.com/read/29664956/you-pray-to-your-god-a-qualitative-analysis-of-challenges-in-the-provision-of-safe-timely-and-affordable-surgical-care-in-uganda
#6
Katherine Albutt, Rachel R Yorlets, Maria Punchak, Peter Kayima, Didacus B Namanya, Geoffrey A Anderson, Mark G Shrime
BACKGROUND: Five billion people lack access to safe, affordable, and timely surgical and anesthesia care. Significant challenges remain in the provision of surgical care in low-resource settings. Uganda is no exception. METHODS: From September to November 2016, we conducted a mixed-methods countrywide surgical capacity assessment at 17 randomly selected public hospitals in Uganda. Researchers conducted 35 semi-structured interviews with key stakeholders to understand factors related to the provision of surgical care...
2018: PloS One
https://www.readbyqxmd.com/read/29662247/the-nitrogen-balancing-act-tracking-the-environmental-performance-of-food-production
#7
Eileen L McLellan, Kenneth G Cassman, Alison J Eagle, Peter B Woodbury, Shai Sela, Christina Tonitto, Rebecca D Marjerison, Harold M van Es
Farmers, food supply-chain entities, and policymakers need a simple but robust indicator to demonstrate progress toward reducing nitrogen pollution associated with food production. We show that nitrogen balance-the difference between nitrogen inputs and nitrogen outputs in an agricultural production system-is a robust measure of nitrogen losses that is simple to calculate, easily understood, and based on readily available farm data. Nitrogen balance provides farmers with a means of demonstrating to an increasingly concerned public that they are succeeding in reducing nitrogen losses while also improving the overall sustainability of their farming operation...
March 1, 2018: Bioscience
https://www.readbyqxmd.com/read/29660280/comparison-of-linear-and-hyperbranched-polyether-lipids-for-liposome-shielding-by-18f-radiolabeling-and-positron-emission-tomography
#8
Karolin Wagener, Matthias Worm, Stefanie Pektor, Meike Schinnerer, Raphael Thiermann, Matthias Miederer, Holger Frey, Frank Rösch
Multifunctional and highly biocompatible polyether structures play a key role in shielding liposomes from degradation in the bloodstream, providing also multiple functional groups for further attachment of targeting moieties. In this work hyperbranched polyglycerol (hbPG) bearing lipids with long alkyl chain anchor are evaluated with respect to steric stabilization of liposomes. The branched polyether lipids possess a hydrophobic bis(hexadecyl)glycerol membrane anchor for the liposomal membrane. hbPG was chosen as a multifunctional alternative to PEG, enabling the eventual linkage of multiple targeting vectors...
April 16, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29659970/cholic-acid-supplementation-of-a-high-fat-obesogenic-diet-suppresses-hepatic-triacylglycerol-accumulation-in-mice-via-a-fibroblast-growth-factor-21-dependent-mechanism
#9
Siri M Ippagunta, Alexei Kharitonenkov, Andrew C Adams, F Bradley Hillgartner
Background: Supplementation of a high-fat obesogenic diet (HFD) with cholic acid (CA) suppresses the development of obesity, insulin resistance, and hepatic steatosis in mice. Objective: We investigated the role of fibroblast growth factor 21 (FGF21) in mediating the beneficial actions of CA on metabolic syndrome. Methods: Male 7-wk-old wild-type (WT) mice and FGF21 knockout (FGF21KO) mice were fed an HFD for 12 wk followed by a 4-wk period in which the mice were fed the HFD alone or supplemented with 0...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29652931/correction-network-evolution-model-for-supply-chain-with-manufactures-as-the-core
#10
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0191180.].
2018: PloS One
https://www.readbyqxmd.com/read/29651749/medium-chain-triglycerides-supplement-therapy-with-a-low-carbohydrate-formula-can-supply-energy-and-enhance-ammonia-detoxification-in-the-hepatocytes-of-patients-with-adult-onset-type-ii-citrullinemia
#11
Kiyoshi Hayasaka, Chikahiko Numakura, Mitsunori Yamakawa, Tetsuo Mitsui, Hisayoshi Watanabe, Hiroaki Haga, Masahide Yazaki, Hiromasa Ohira, Yasuo Ochiai, Toshiyuki Tahara, Tamio Nakahara, Noriyo Yamashiki, Takahiro Nakayama, Takashi Kon, Hiroshi Mitsubuchi, Hiroshi Yoshida
Citrin, encoded by SLC25A13, constitutes the malate-aspartate shuttle, the main NADH-shuttle in the liver. Citrin deficiency causes neonatal intrahepatic cholestasis (NICCD) and adult-onset type II citrullinemia (CTLN2). Citrin deficiency is predicted to impair hepatic glycolysis and de novo lipogenesis, resulting in hepatic energy deficit. Secondary decrease in hepatic argininosuccinate synthetase (ASS1) expression has been considered a cause of hyperammonemia in CTLN2. We previously reported that medium-chain triglyceride (MCT) supplement therapy with a low-carbohydrate formula was effective in CTLN2 to prevent a relapse of hyperammonemic encephalopathy...
April 12, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29650002/identifying-bottlenecks-in-the-iron-and-folic-acid-supply-chain-in-bihar-india-a-mixed-methods-study
#12
Amanda S Wendt, Rob Stephenson, Melissa F Young, Pankaj Verma, Sridhar Srikantiah, Amy Webb-Girard, Carol J Hogue, Usha Ramakrishnan, Reynaldo Martorell
BACKGROUND: Maternal anaemia prevalence in Bihar, India remains high despite government mandated iron supplementation targeting pregnant women. Inadequate supply has been identified as a potential barrier to iron and folic acid (IFA) receipt. Our study objective was to examine the government health system's IFA supply and distribution system and identify bottlenecks contributing to insufficient IFA supply. METHODS: Primary data collection was conducted in November 2011 and July 2012 across 8 districts in Bihar, India...
April 12, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29649315/retailer-stackelberg-game-in-a-supply-chain-with-pricing-and-service-decisions-and-simple-price-discount-contract
#13
Seyed Jafar Sadjadi, Hashem Asadi, Ramin Sadeghian, Hadi Sahebi
This paper studies the Retailer Stackelberg game in a supply chain consisting of two manufacturers and one retailer where they compete simultaneously under three factors including price, service and simple price discount contract. It is assumed that the second manufacturer provides service directly to his customers, and the retailer provides service for the first product's customers, while the retailer buys the first product under price discount from the first manufacturer. The analysis of the optimal equilibrium solutions and the results of the numerical examples show that if a manufacturer chooses the appropriate range of discount rate, he will gain more profit than when there is no discount given to the retailer...
2018: PloS One
https://www.readbyqxmd.com/read/29648523/feasibility-and-costs-of-a-targeted-cholera-vaccination-campaign-in-ethiopia
#14
Samuel Teshome, Sachin Desai, Jerome H Kim, Dires Belay, Vittal Mogasale
Shanchol™, a WHO-prequalified oral cholera vaccine (OCV), has been used to control endemic cholera in Asia, as well as in emergencies and outbreaks elsewhere. The vaccine has not been used by public health systems in cholera-endemic settings of Africa although several outbreak response campaigns have been conducted. Here we present experiences from a mass vaccination campaign in a cholera-endemic setting of Ethiopia in which Shanchol™ was introduced through the public health system. The vaccination site was selected based on cholera cases reported in previous years...
April 12, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29643356/disc1-regulates-lactate-metabolism-in-astrocytes-implications-for-psychiatric-disorders
#15
Yan Jouroukhin, Yusuke Kageyama, Varvara Misheneva, Alexey Shevelkin, Shaida Andrabi, Emese Prandovszky, Robert H Yolken, Valina L Dawson, Ted M Dawson, Susan Aja, Hiromi Sesaki, Mikhail V Pletnikov
Our knowledge of how genetic risk variants contribute to psychiatric disease is mainly limited to neurons. However, the mechanisms whereby the same genetic risk factors could affect the physiology of glial cells remain poorly understood. We studied the role of a psychiatric genetic risk factor, Disrupted-In-Schizophrenia-1 (DISC1), in metabolic functions of astrocytes. We evaluated the effects of knockdown of mouse endogenous DISC1 (DISC1-KD) and expression of a dominant-negative, C-terminus truncated human DISC1 (DN-DISC1) on the markers of energy metabolism, including glucose uptake and lactate production, in primary astrocytes and in mice with selective expression of DN-DISC1 in astrocytes...
April 12, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29642662/current-situation-and-future-prospects-for-the-australian-beef-industry
#16
Paul Leo Greenwood, Drewe M Ferguson
Beef production extends over almost half of Australia, with about 47,000 cattle producers that contribute about 20% ($A12.7 billion GVP) of the total value of farm production in Australia. Australia is one of the world's most efficient producers of cattle and was the world's third largest beef exporter in 2016. The Australian beef industry had 25 million head of cattle in 2016-17, with a national beef breeding herd of 11.5 million head. Australian beef production includes pasture based cow-calf systems, a backgrounding or grow-out period on pasture, and feedlot or pasture finishing...
April 12, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29621564/past-present-and-future-of-hepatitis-e-virus-infection-zoonotic-perspectives
#17
REVIEW
Shahid Faraz Syed, Qin Zhao, Muhammad Umar, Mahmoud Alagawany, Imtiaz Ahmed Ujjan, Feroza Soomro, Nasrullah Bangulzai, Abdul Hameed Baloch, Mohamed Abd El-Hack, En-Min Zhou, Muhammad Asif Arain
The origin of hepatitis E virus (HEV) is not fully understood, but it is considered an emerging zoonotic pathogen. To date, HEV has been isolated from many animal species. The family Hepeviridae consists of two genera. The genus Orthohepevirus includes four distinct species (A, B, C, and D), each with distinct genotypes. Within the Orthohepevirus A species, HEV-1 and HEV-2 host ranges are restricted to humans, whereas genotypes 3 and 4 primarily infect a wide range of diverse animal species, in addition to being zoonotic to humans...
April 2, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29620147/lncrna-pvt1-promotes-the-angiogenesis-of-vascular-endothelial-cell-by-targeting-mir%C3%A2-26b-to-activate-ctgf-angpt2
#18
Jifu Zheng, Lili Hu, Jing Cheng, Jing Xu, Zhiqiang Zhong, Yuan Yang, Zheng Yuan
Angiogenesis is essential for various biological processes, including tumor blood supply delivery, cancer cell growth, invasion and metastasis. Plasmacytoma variant translocation 1 (PVT1) long noncoding RNA (lncRNA) has been previously reported to affect angiogenesis of glioma microvascular endothelial cells by regulating microRNA (miR)‑186 expression level. However, the specific underlying molecular mechanism of PVT1 regulation of angiogenesis in vascular endothelial cells remains to be elucidated. The present study investigated the role of PVT1 in cell proliferation, migration and vascular tube formation of human umbilical vein endothelial cells (HUVECs) using MTT assay, Transwell migration assay and in vitro vascular tube formation assay, respectively...
March 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29617309/the-mycotox-charter-increasing-awareness-of-and-concerted-action-for-minimizing-mycotoxin-exposure-worldwide
#19
Antonio F Logrieco, J David Miller, Mari Eskola, Rudolf Krska, Amare Ayalew, Ranajit Bandyopadhyay, Paola Battilani, Deepak Bhatnagar, Sofia Chulze, Sarah De Saeger, Peiwu Li, Giancarlo Perrone, Amnart Poapolathep, Endang S Rahayu, Gordon S Shephard, François Stepman, Hao Zhang, John F Leslie
Mycotoxins are major food contaminants affecting global food security, especially in low and middle-income countries. The European Union (EU) funded project, MycoKey, focuses on “Integrated and innovative key actions for mycotoxin management in the food and feed chains” and the right to safe food through mycotoxin management strategies and regulation, which are fundamental to minimizing the unequal access to safe and sufficient food worldwide. As part of the MycoKey project, a Mycotoxin Charter (charter...
April 4, 2018: Toxins
https://www.readbyqxmd.com/read/29616479/the-role-of-the-water-footprint-in-the-context-of-green-marketing
#20
Stella Symeonidou, Dimitra Vagiona
The environmental degradation, because of various factors, such as climate change, human activities, increase of population globally, etc. have brought on pressures on the fresh water supplies that vary on time and space. Consequently, economic, environmental, and social tools have emerged known as footprints, in an effort to examine and measure the needs and consequences of humanity on the Earth's life support systems and take measures towards sustainable development. Furthermore, the constantly worsening environmental conditions have resulted in the cultivation of a green culture among society stakeholders that brought on terms such as green marketing and green products...
April 3, 2018: Environmental Science and Pollution Research International
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