Joseph W Song, Hanjun Ryu, Wubin Bai, Zhaoqian Xie, Abraham Vázquez-Guardado, Khizar Nandoliya, Raudel Avila, Geumbee Lee, Zhen Song, Jihye Kim, Min-Kyu Lee, Yugang Liu, Mirae Kim, Huifeng Wang, Yixin Wu, Hong-Joon Yoon, Sung Soo Kwak, Jaeho Shin, Kyeongha Kwon, Wei Lu, Xuexian Chen, Yonggang Huang, Guillermo A Ameer, John A Rogers
Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use...
February 22, 2023: Science Advances