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https://www.readbyqxmd.com/read/27913137/time-lapse-microscopy-patent-upheld-in-europe-response-to-pearce
#1
Sigrid Sterckx, Julian Cockbain, Guido Pennings
In this piece, we comment on the article by Pearce earlier in this journal. As Pearce correctly points out, what is fundamentally at issue in ESHRE et al's opposition to Stanford University's European patent on time-lapse microscopy is whether an exclusion from patentability, here of methods of medical diagnosis, should be interpreted narrowly or not. In the present case, the dominant piece of case law from the European Patent Office (EPO) gives a narrow interpretation of what a method of diagnosis must be in order not to be patentable...
November 16, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27909568/implementation-of-minimal-invasive-gynaecological-surgery-certification-will-challenge-gynaecologists-with-new-legal-and-ethical-issues
#2
V Tanos, R Socolov, P Demetriou, M Kyprianou, A Watrelot, Y Van Belle, R Campo
The introduction of a certification / diploma program in Minimal Invasive Surgery (MIS) is expected to improve surgical performance, patient's safety and outcome. The Gynaecological Endoscopic Surgical Education and Assessment programme (GESEA) and the ESHRE Certification for Reproductive Endoscopic Surgery (ECRES) provides a structured learning path, recognising different pillars of competence. In order to achieve a high level of competence a two steps validation is necessary: (a) the individual should be certified of having the appropriate theoretical knowledge and (b) the endoscopic psychomotor skills before entering in the diploma programme reflecting the surgical competence...
June 27, 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27908603/patenting-medical-diagnosis-methods-in-europe-stanford-university-and-time-lapse-microscopy
#3
Sigrid Sterckx, Julian Cockbain, Guido Pennings
In 2013, a European Patent for the technique of time-lapse microscopy was granted by the European Patent Office (EPO) to Stanford University and was subsequently opposed by Unisense FertiliTech A/S and by the European Society for Human Reproduction and Embryology (ESHRE), Sigrid Sterckx, Julian Cockbain and Guido Pennings. ESHRE et al.'s opposition was based on the argument that Stanford's patent was directed to a method of medical diagnosis, methods that are excluded from patentability by Article 53(c) of the European Patent Convention...
November 18, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27822350/surgical-excision-of-essure%C3%A2-devices-with-eshre-class-iib-uterine-malformation-sequential-hysteroscopic-laparoscopic-approach-to-the-septate-uterus
#4
E S Sills, G D Palermo
OBJECTIVE: While contraindications to Essure® placement have been provided by the manufacturer, there is no consensus on how best to remove these contraceptive devices. Here, we describe a non-hysterectomy removal of Essure® for a patient with a septate uterus (ESHRE Class IIb uterine malformation). CLINICAL CASE: A 35yr old G4 P2 presented for removal of Essure® implants after three years of gradually increasing pelvic pain, weight gain, headache, dizziness, lower extremity paresthesia, and fatigue which followed hysteroscopic sterilization (HS)...
March 28, 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27702705/robotic-assisted-reconstruction-of-cervix-and-vagina-by-sis-graft-and-fusion-of-hemi-uterus
#5
Ying Zhang, Yisong Chen, Keqin Hua
STUDY OBJECTIVE: To describe our technique of robotic assisted reconstruction of cervix and vagina by SIS (small intestinal sub-mucosa, SIS) graft and fusion of hemi-uterus. DESIGN: Step-by-step explanation of the procedure using video. SETTING: Congenital complete vaginal and cervical atresia is rare. Some patient has urinary system abnormality. No standardized surgical treatment guideline was available and the performance is varying for each patient...
October 1, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27693935/distribution-of-female-genital-tract-anomalies-in-two-classifications
#6
Pentti K Heinonen
OBJECTIVE: This study assessed the distribution of Müllerian duct anomalies in two verified classifications of female genital tract malformations, and the presence of associated renal defects. STUDY DESIGN: 621 women with confirmed female genital tract anomalies were retrospectively grouped under the European (ESHRE/ESGE) and the American (AFS) classification. The diagnosis of uterine malformation was based on findings in hysterosalpingography, two-dimensional ultrasonography, endoscopies, laparotomy, cesarean section and magnetic resonance imaging in 97...
September 20, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27664216/the-prevalence-and-phenotypic-features-of-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#7
Gurkan Bozdag, Sezcan Mumusoglu, Dila Zengin, Erdem Karabulut, Bulent Okan Yildiz
STUDY QUESTION: What is the reported overall prevalence of polycystic ovary syndrome (PCOS) according to the criteria of the National Institutes of Health (NIH), Rotterdam or the Androgen Excess and PCOS Society (AE-PCOS Society)? SUMMARY ANSWER: The reported overall prevalence of PCOS (95% CI) according to diagnostic criteria of the NIH, Rotterdam and the AE-PCOS Society is 6% (5-8%, n = 18 trials), 10% (8-13%, n = 15 trials) and 10% (7-13%, n = 10 trials), respectively...
September 22, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27642107/helicobacter-pylori-infection-and-polycystic-ovary-syndrome-in-adolescent-and-young-adult-patients
#8
Aytekin Tokmak, Zeynal Doğan, Esma Sarıkaya, Hakan Timur, Murat Kekilli
AIM: Polycystic ovary syndrome (PCOS) is the most common cause of infertility among women of reproductive age. Chronic systemic inflammation has been considered to play a role in the development of PCOS. Helicobacter pylori has been shown to lead to both local gastric and chronic systemic inflammation. In the light of this, the aim of the present study was to investigate a possible link between H. pylori and PCOS. METHODS: A total of 167 nullipar and single adolescent and young adults (AYA) were recruited for the study: 86 (51...
September 19, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27634940/lipid-accumulation-product-as-a-marker-of-cardiometabolic-susceptibility-in-women-with-different-phenotypes-of-polycystic-ovary-syndrome
#9
Ivana Božić-Antić, Dušan Ilić, Jelica Bjekić-Macut, Tamara Bogavac, Danijela Vojnović Milutinović, Biljana Kastratović-Kotlica, Nataša Milić, Olivera Stanojlović, Zoran Andrić, Djuro Macut
OBJECTIVE: There are limited data on cardiometabolic risk factors, and prevalence of metabolic syndrome (MetS) across the different PCOS phenotypes in Caucasian population. Lipid accumulation product (LAP) is a clinical surrogate marker that could be used for evaluation of MetS in clinical practice. The aim of the study was to analyze metabolic characteristics and ability of LAP to predict MetS in different PCOS phenotypes. DESIGN: Cross-sectional clinical study analyzing 365 women with PCOS divided into four phenotypes according to the ESHRE/ASRM criteria, and 125 healthy BMI-matched controls...
September 15, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27609983/use-of-donor-sperm-in-addition-to-oocyte-donation-after-repeated-implantation-failure-in-normozoospermic-patients-does-not-improve-live-birth-rates
#10
A Blázquez, D García, A Rodríguez, R Vassena, V Vernaeve
STUDY QUESTION: Does switching to donor semen after at least three failed oocyte donation (OD) cycles with the partner normozoospermic semen increase the live birth rate in a subsequent OD cycle? SUMMARY ANSWER: Switching to donor semen after at least three failed OD cycles with the partner normozoospermic semen does not increase the live birth rate. WHAT IS ALREADY KNOWN: In some patients, a viable pregnancy cannot be achieved after several OD cycles, despite normal diagnostic findings for the couple...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27609980/development-of-a-generally-applicable-morphokinetic-algorithm-capable-of-predicting-the-implantation-potential-of-embryos-transferred-on-day-3
#11
Bjørn Molt Petersen, Mikkel Boel, Markus Montag, David K Gardner
STUDY QUESTION: Can a generally applicable morphokinetic algorithm suitable for Day 3 transfers of time-lapse monitored embryos originating from different culture conditions and fertilization methods be developed for the purpose of supporting the embryologist's decision on which embryo to transfer back to the patient in assisted reproduction? SUMMARY ANSWER: The algorithm presented here can be used independently of culture conditions and fertilization method and provides predictive power not surpassed by other published algorithms for ranking embryos according to their blastocyst formation potential...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27560353/chromosomal-polymorphic-variants-increase-aneuploidies-in-male-gametes-and-embryos
#12
Ruth Morales, Belén Lledó, José A Ortiz, Jorge Ten, Joaquin Llácer, Rafael Bernabeu
UNLABELLED: Chromosomal polymorphisms involve heterochromatic regions and occur in the general population. However, previous studies have reported a higher incidence of these variants in infertile patients. The aim of this study was to examine the relationship between polymorphic variants and infertility and their association with aneuploidies in male gametes and embryos. We retrospectively considered 1,551 cytogenetic studies involving infertile patients (study group; n=866) and oocyte/sperm donors as the control group (n=685)...
October 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27554442/time-to-take-human-embryo-culture-seriously
#13
Arne Sunde, Daniel Brison, John Dumoulin, Joyce Harper, Kersti Lundin, M Cristina Magli, Etienne Van den Abbeel, Anna Veiga
STUDY QUESTION: Is it important that end-users know the composition of human embryo culture media? SUMMARY ANSWER: We argue that there is as strong case for full transparency concerning the composition of embryo culture media intended for human use. WHAT IS KNOWN ALREADY: Published data suggest that the composition of embryo culture media may influence the phenotype of the offspring. STUDY DESIGN, SIZE, DURATION: A review of the literature was carried out...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27502954/serum-macroelement-and-microelement-concentrations-in-patients-with-polycystic-ovary-syndrome-a-cross-sectional-study
#14
Muyan Li, Yuanyuan Tang, Chunlei Lin, Qiaoying Huang, Danqing Lei, Yanling Hu
Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases. However, its pathogenesis is unclear. We aim to explore the potential relationships between serum macroelements/microelements and PCOS. A total of 1137 women were involved in the current study. PCOS was defined according to ESHRE/ASRM, and complete blood samples were collected. Serum macroelements (calcium and magnesium) and microelements (copper, zinc, and iron) were assayed through atomic absorption spectrophotometry. PCOS patients had significantly higher copper concentrations than patients without PCOS (P < 0...
August 9, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27496943/assisted-reproductive-technology-in-europe-2012-results-generated-from-european-registers-by-eshre
#15
C Calhaz-Jorge, C de Geyter, M S Kupka, J de Mouzon, K Erb, E Mocanu, T Motrenko, G Scaravelli, C Wyns, V Goossens
STUDY QUESTION: The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years? SUMMARY ANSWER: Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before...
August 2016: Human Reproduction
https://www.readbyqxmd.com/read/27422679/-surgical-management-of-endometrioma-result-of-french-practice-survey
#16
L Delbos, G Legendre, M Rousseau, L Catala, C Lefebvre-Lacoeuille, P-E Bouet, P Descamps
OBJECTIVES: There are many national and international recommendations and guidelines for the management of patients with endometrioma. In this study, we aimed to evaluate the impact of these recommendations on the practice of French surgeons, and to assess their knowledge about the management of endometriomas. MATERIALS AND METHODS: A self-questionnaire has been sent to the French members of the Society of Gynecologic Surgery and Pelvic (SCGP) in May 2015. RESULTS: One hundred and forty-four members of the society (36 %) participated in the survey...
July 12, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27334335/the-influence-of-social-factors-on-gender-health
#17
REVIEW
(no author information available yet)
Male births exceed female births by 5-6% (for a sex ratio at birth of 1.05-1.06) while a women's life expectancy, on a global scale, is about 6 years longer. Thus within various age groups the male:female ratio changes over time. Until age 50 years men outnumber women; thereafter their numbers show a sharp decline. Consequently at age 80 years, there are many more women than men. An estimated 25% of this male excess mortality is due to biological causes, the rest being explained by behavioural, cultural and environmental factors...
August 2016: Human Reproduction
https://www.readbyqxmd.com/read/27173790/do-the-anti-m%C3%A3-llerian-hormone-levels-of-adolescents-with-polycystic-ovary-syndrome-those-who-are-at-risk-for-developing-polycystic-ovary-syndrome-and-those-who-exhibit-isolated-oligomenorrhea-differ-from-those-of-adolescents-with-normal-menstrual-cycles
#18
Senay Savas-Erdeve, Meliksah Keskin, Elif Sagsak, Funda Cenesiz, Semra Cetinkaya, Zehra Aycan
BACKGROUND/AIMS: We aimed to investigate whether the anti-Müllerian hormone (AMH) levels in adolescents with polycystic ovary syndrome (PCOS), PCOS risk, and isolated oligomenorrhea (OM) were different than in adolescents with a normal/regular menstrual cycle (NMC). METHODS: The diagnosis of PCOS was based on the 2012 Amsterdam [European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)] criteria. The PCOS group consisted of cases meeting 3 diagnostic criteria (n = 21), and the PCOS risk group was the 'at risk' group meeting 2 diagnostic criteria (n = 20)...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27126581/gonadotrophin-releasing-hormone-antagonists-for-assisted-reproductive-technology
#19
REVIEW
Hesham G Al-Inany, Mohamed A Youssef, Reuben Olugbenga Ayeleke, Julie Brown, Wai Sun Lam, Frank J Broekmans
BACKGROUND: Gonadotrophin-releasing hormone (GnRH) antagonists can be used to prevent a luteinizing hormone (LH) surge during controlled ovarian hyperstimulation (COH) without the hypo-oestrogenic side-effects, flare-up, or long down-regulation period associated with agonists. The antagonists directly and rapidly inhibit gonadotrophin release within several hours through competitive binding to pituitary GnRH receptors. This property allows their use at any time during the follicular phase...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27112700/selection-of-key-recommendations-for-the-management-of-women-with-endometriosis-by-an-international-panel-of-patients-and-professionals
#20
M J Schleedoorn, W L D M Nelen, G A J Dunselman, N Vermeulen
STUDY QUESTION: Can the differences in patients' and professionals' perspective regarding essential endometriosis care be accommodated in one set of key recommendations? SUMMARY ANSWER: Consensus between patients and professions on a key set of recommendations for essential endometriosis care was achieved. WHAT IS KNOWN ALREADY: Guideline development alone will not lead to healthcare improvement. Quality indicators are needed to monitor actual care and guideline adherence...
June 2016: Human Reproduction
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