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https://www.readbyqxmd.com/read/28178574/is-acne-a-sign-of-androgen-excess-disorder-or-not
#1
Gulsum Uysal, Yılmaz Sahin, Kursad Unluhizarci, Ayten Ferahbas, Semih Zeki Uludag, Ercan Aygen, Fahrettin Kelestimur
OBJECTIVE: Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Our aim was to investigate whether acne is a sign of androgen excess disorder or not. STUDY DESIGN: This is a cross sectional study that was performed in a university hospital involving 207 women, aged between 18 and 45 years, suffering mainly from acne...
January 23, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28173995/gnrh-antagonist-and-letrozole-co-treatment-in-diminished-ovarian-reserve-patients-a-proof-of-concept-study
#2
Safak Olgan, Peter Humaidan
The current study aimed to investigate the effects of luteal gonadotropin-releasing hormone (GnRH) antagonist pretreatment on the outcomes of diminished ovarian reserve (DOR) patients who were treated using a FSH/letrozole/GnRH antagonist (FLA) protocol. Thus, patients who had luteal GnRH antagonist pretreatment (AFLA) prior to stimulation were compared to patients who had the FLA protocol, only. An electronic database was used to identify patients and stimulation characteristics. Women who had a total antral follicle count (AFC) of <7 were included in the analysis...
February 4, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28137754/efficacy-and-safety-of-follitropin-alfa-lutropin-alfa-in-art-a-randomized-controlled-trial-in-poor-ovarian-responders
#3
P Humaidan, W Chin, D Rogoff, T D'Hooghe, S Longobardi, J Hubbard, J Schertz
STUDY QUESTION: How does the efficacy and safety of a fixed-ratio combination of recombinant human FSH plus recombinant human LH (follitropin alfa plus lutropin alfa; r-hFSH/r-hLH) compare with that of r-hFSH monotherapy for controlled ovarian stimulation (COS) in patients with poor ovarian response (POR)? SUMMARY ANSWER: The primary and secondary efficacy endpoints were comparable between treatment groups and the safety profile of both treatment regimens was favourable...
January 30, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28057875/perceived-challenges-of-working-in-a-fertility-clinic-a-qualitative-analysis-of-work-stressors-and-difficulties-working-with-patients
#4
Jacky Boivin, Laura Bunting, Emily Koert, Chin Ieng U, Christianne Verhaak
STUDY QUESTION: What are some of the challenges of working in a fertility clinic? SUMMARY ANSWER: The most frequently mentioned challenges were workload (e.g. high time pressure) and patient-related sources (e.g. unrealistic expectations). WHAT IS KNOWN ALREADY: One study showed a too high workload, worry about handling human material and low success rates were main stressors in fertility clinics. STUDY DESIGN, SIZE, DURATION: An online open-ended survey inviting participants to respond to seven questions was distributed to 5902 members of the European Society for Human Reproduction and Embryology (ESHRE, October 2010)...
January 5, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28019133/the-effects-of-il-1a-and-il-6-genes-polymorphisms-on-gene-expressions-hormonal-and-biochemical-parameters-in-polycystic-ovary-syndrome
#5
Betul Eser, Mine Islimye Taskin, Adnan Adil Hismiogullari, Hasan Aksit, Abdurrahman Said Bodur
Polycystic ovary syndrome (PCOS) is a multifactorial disease characterised by chronic inflammation. We aimed to investigate an association between IL-1A and IL-6 gene polymorphisms and both hormonal/biochemical parameters and levels of IL-1A and IL-6. A total of 103 women diagnosed with PCOS according to ESHRE/ASRM criteria were investigated. The patients were divided into two groups as obese and non-obese. IL-1A and IL-6 genes polymorphisms as well as hormonal/biochemical parameters and levels of IL-1A and IL-6 were analysed in the same groups...
December 26, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27913137/time-lapse-microscopy-patent-upheld-in-europe-response-to-pearce
#6
Sigrid Sterckx, Julian Cockbain, Guido Pennings
In this piece, we comment on the article by Pearce earlier in this journal. As Pearce correctly points out, what is fundamentally at issue in ESHRE et al's opposition to Stanford University's European patent on time-lapse microscopy is whether an exclusion from patentability, here of methods of medical diagnosis, should be interpreted narrowly or not. In the present case, the dominant piece of case law from the European Patent Office (EPO) gives a narrow interpretation of what a method of diagnosis must be in order not to be patentable...
February 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27909568/implementation-of-minimal-invasive-gynaecological-surgery-certification-will-challenge-gynaecologists-with-new-legal-and-ethical-issues
#7
V Tanos, R Socolov, P Demetriou, M Kyprianou, A Watrelot, Y Van Belle, R Campo
The introduction of a certification / diploma program in Minimal Invasive Surgery (MIS) is expected to improve surgical performance, patient's safety and outcome. The Gynaecological Endoscopic Surgical Education and Assessment programme (GESEA) and the ESHRE Certification for Reproductive Endoscopic Surgery (ECRES) provides a structured learning path, recognising different pillars of competence. In order to achieve a high level of competence a two steps validation is necessary: (a) the individual should be certified of having the appropriate theoretical knowledge and (b) the endoscopic psychomotor skills before entering in the diploma programme reflecting the surgical competence...
June 27, 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27908603/patenting-medical-diagnosis-methods-in-europe-stanford-university-and-time-lapse-microscopy
#8
Sigrid Sterckx, Julian Cockbain, Guido Pennings
In 2013, a European Patent for the technique of time-lapse microscopy was granted by the European Patent Office (EPO) to Stanford University and was subsequently opposed by Unisense FertiliTech A/S and by the European Society for Human Reproduction and Embryology (ESHRE), Sigrid Sterckx, Julian Cockbain and Guido Pennings. ESHRE et al.'s opposition was based on the argument that Stanford's patent was directed to a method of medical diagnosis, methods that are excluded from patentability by Article 53(c) of the European Patent Convention...
February 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27822350/surgical-excision-of-essure%C3%A2-devices-with-eshre-class-iib-uterine-malformation-sequential-hysteroscopic-laparoscopic-approach-to-the-septate-uterus
#9
E S Sills, G D Palermo
OBJECTIVE: While contraindications to Essure® placement have been provided by the manufacturer, there is no consensus on how best to remove these contraceptive devices. Here, we describe a non-hysterectomy removal of Essure® for a patient with a septate uterus (ESHRE Class IIb uterine malformation). CLINICAL CASE: A 35yr old G4 P2 presented for removal of Essure® implants after three years of gradually increasing pelvic pain, weight gain, headache, dizziness, lower extremity paresthesia, and fatigue which followed hysteroscopic sterilization (HS)...
March 28, 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27702705/robotic-assisted-reconstruction-of-the-cervix-and-vagina-by-small-intestinal-submucosa-graft-and-fusion-of-the-hemiuterus
#10
Ying Zhang, Yisong Chen, Keqin Hua
STUDY OBJECTIVE: To describe our technique of robotic-assisted reconstruction of the cervix and vagina using a small intestinal submucosa (SIS) graft and fusion of the hemiuterus. DESIGN: A step-by-step explanation of the procedure using video. SETTING: Congenital complete vaginal and cervical atresia is rare. Some patients have urinary system abnormality. No standardized surgical treatment guideline was available, and the performance varies for each patient...
October 1, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27693935/distribution-of-female-genital-tract-anomalies-in-two-classifications
#11
Pentti K Heinonen
OBJECTIVE: This study assessed the distribution of Müllerian duct anomalies in two verified classifications of female genital tract malformations, and the presence of associated renal defects. STUDY DESIGN: 621 women with confirmed female genital tract anomalies were retrospectively grouped under the European (ESHRE/ESGE) and the American (AFS) classification. The diagnosis of uterine malformation was based on findings in hysterosalpingography, two-dimensional ultrasonography, endoscopies, laparotomy, cesarean section and magnetic resonance imaging in 97...
November 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27664216/the-prevalence-and-phenotypic-features-of-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#12
Gurkan Bozdag, Sezcan Mumusoglu, Dila Zengin, Erdem Karabulut, Bulent Okan Yildiz
STUDY QUESTION: What is the reported overall prevalence of polycystic ovary syndrome (PCOS) according to the criteria of the National Institutes of Health (NIH), Rotterdam or the Androgen Excess and PCOS Society (AE-PCOS Society)? SUMMARY ANSWER: The reported overall prevalence of PCOS (95% CI) according to diagnostic criteria of the NIH, Rotterdam and the AE-PCOS Society is 6% (5-8%, n = 18 trials), 10% (8-13%, n = 15 trials) and 10% (7-13%, n = 10 trials), respectively...
September 22, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27642107/helicobacter-pylori-infection-and-polycystic-ovary-syndrome-in-adolescent-and-young-adult-patients
#13
Aytekin Tokmak, Zeynal Doğan, Esma Sarıkaya, Hakan Timur, Murat Kekilli
AIM: Polycystic ovary syndrome (PCOS) is the most common cause of infertility among women of reproductive age. Chronic systemic inflammation has been considered to play a role in the development of PCOS. Helicobacter pylori has been shown to lead to both local gastric and chronic systemic inflammation. In the light of this, the aim of the present study was to investigate a possible link between H. pylori and PCOS. METHODS: A total of 167 nullipar and single adolescent and young adults (AYA) were recruited for the study: 86 (51...
December 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27634940/lipid-accumulation-product-as-a-marker-of-cardiometabolic-susceptibility-in-women-with-different-phenotypes-of-polycystic-ovary-syndrome
#14
Ivana Božić-Antić, Dušan Ilić, Jelica Bjekić-Macut, Tamara Bogavac, Danijela Vojnović-Milutinović, Biljana Kastratovic-Kotlica, Nataša Milić, Olivera Stanojlović, Zoran Andrić, Djuro Macut
OBJECTIVE: There are limited data on cardiometabolic risk factors and the prevalence of metabolic syndrome (MetS) across the different PCOS phenotypes in Caucasian population. Lipid accumulation product (LAP) is a clinical surrogate marker that could be used for evaluation of MetS in clinical practice. The aim of the study was to analyze metabolic characteristics and the ability of LAP to predict MetS in different PCOS phenotypes. DESIGN: Cross-sectional clinical study analyzing 365 women with PCOS divided into four phenotypes according to the ESHRE/ASRM criteria, and 125 healthy BMI-matched controls...
December 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27609983/use-of-donor-sperm-in-addition-to-oocyte-donation-after-repeated-implantation-failure-in-normozoospermic-patients-does-not-improve-live-birth-rates
#15
A Blázquez, D García, A Rodríguez, R Vassena, V Vernaeve
STUDY QUESTION: Does switching to donor semen after at least three failed oocyte donation (OD) cycles with the partner normozoospermic semen increase the live birth rate in a subsequent OD cycle? SUMMARY ANSWER: Switching to donor semen after at least three failed OD cycles with the partner normozoospermic semen does not increase the live birth rate. WHAT IS ALREADY KNOWN: In some patients, a viable pregnancy cannot be achieved after several OD cycles, despite normal diagnostic findings for the couple...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27609980/development-of-a-generally-applicable-morphokinetic-algorithm-capable-of-predicting-the-implantation-potential-of-embryos-transferred-on-day-3
#16
Bjørn Molt Petersen, Mikkel Boel, Markus Montag, David K Gardner
STUDY QUESTION: Can a generally applicable morphokinetic algorithm suitable for Day 3 transfers of time-lapse monitored embryos originating from different culture conditions and fertilization methods be developed for the purpose of supporting the embryologist's decision on which embryo to transfer back to the patient in assisted reproduction? SUMMARY ANSWER: The algorithm presented here can be used independently of culture conditions and fertilization method and provides predictive power not surpassed by other published algorithms for ranking embryos according to their blastocyst formation potential...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27560353/chromosomal-polymorphic-variants-increase-aneuploidies-in-male-gametes-and-embryos
#17
Ruth Morales, Belén Lledó, José A Ortiz, Jorge Ten, Joaquin Llácer, Rafael Bernabeu
UNLABELLED: Chromosomal polymorphisms involve heterochromatic regions and occur in the general population. However, previous studies have reported a higher incidence of these variants in infertile patients. The aim of this study was to examine the relationship between polymorphic variants and infertility and their association with aneuploidies in male gametes and embryos. We retrospectively considered 1,551 cytogenetic studies involving infertile patients (study group; n=866) and oocyte/sperm donors as the control group (n=685)...
October 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27554442/time-to-take-human-embryo-culture-seriously
#18
Arne Sunde, Daniel Brison, John Dumoulin, Joyce Harper, Kersti Lundin, M Cristina Magli, Etienne Van den Abbeel, Anna Veiga
STUDY QUESTION: Is it important that end-users know the composition of human embryo culture media? SUMMARY ANSWER: We argue that there is as strong case for full transparency concerning the composition of embryo culture media intended for human use. WHAT IS KNOWN ALREADY: Published data suggest that the composition of embryo culture media may influence the phenotype of the offspring. STUDY DESIGN, SIZE, DURATION: A review of the literature was carried out...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27502954/serum-macroelement-and-microelement-concentrations-in-patients-with-polycystic-ovary-syndrome-a-cross-sectional-study
#19
Muyan Li, Yuanyuan Tang, Chunlei Lin, Qiaoying Huang, Danqing Lei, Yanling Hu
Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases. However, its pathogenesis is unclear. We aim to explore the potential relationships between serum macroelements/microelements and PCOS. A total of 1137 women were involved in the current study. PCOS was defined according to ESHRE/ASRM, and complete blood samples were collected. Serum macroelements (calcium and magnesium) and microelements (copper, zinc, and iron) were assayed through atomic absorption spectrophotometry. PCOS patients had significantly higher copper concentrations than patients without PCOS (P < 0...
August 9, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27496943/assisted-reproductive-technology-in-europe-2012-results-generated-from-european-registers-by-eshre
#20
C Calhaz-Jorge, C de Geyter, M S Kupka, J de Mouzon, K Erb, E Mocanu, T Motrenko, G Scaravelli, C Wyns, V Goossens
STUDY QUESTION: The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years? SUMMARY ANSWER: Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before...
August 2016: Human Reproduction
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