Kabir Ahluwalia, Zhaodong Du, Juan Carlos Martinez-Camarillo, Aditya Naik, Biju B Thomas, Dimitrios Pollalis, Sun Young Lee, Priyal Dave, Eugene Zhou, Zeyang Li, Catherine Chester, Mark S Humayun, Stan G Louie
Retinal degenerative diseases, including age-related macular degeneration and retinitis pigmentosa, significantly contribute to adult blindness. The Royal College of Surgeons (RCS) rat is a well-established disease model for studying these dystrophies; however, molecular investigations remain limited. We conducted a comprehensive analysis of retinal degeneration in RCS rats, including an immunodeficient RCS (iRCS) sub-strain, using ocular coherence tomography, electroretinography, histology, and molecular dissection using transcriptomics and immunofluorescence...
March 28, 2024: International Journal of Molecular Sciences