Bonaventure Ip, Sangqi Pan, Zhong Yuan, Trista Hung, Ho Ko, Xinyi Leng, Yuying Liu, Shuang Li, Sing Yau Lee, Cyrus Cheng, Howard Chan, Vincent Mok, Yannie Soo, Xiaoli Wu, Leong Ting Lui, Rosa Chan, Jill Abrigo, Qi Dou, David Seiffge, Thomas Leung
IMPORTANCE: Intracerebral hemorrhage (ICH) associated with direct oral anticoagulant (DOAC) use carries extremely high morbidity and mortality. The clinical effectiveness of hemostatic therapy is unclear. OBJECTIVE: To compare the clinical and radiological outcomes of DOAC-associated ICH treated with prothrombin complex concentrate (PCC) vs conservative management. DESIGN, SETTING, AND PARTICIPANTS: In this population-based, propensity score-weighted retrospective cohort study, patients who developed DOAC-associated ICH from January 1, 2016, to December 31, 2021, in Hong Kong were identified...
February 5, 2024: JAMA Network Open