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Neuropsychological symptoms of dementia

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https://www.readbyqxmd.com/read/28441649/home-based-physical-behavior-in-late-stage-parkinson-disease-dementia-differences-between-cognitive-subtypes
#1
Bernhard Cerff, Walter Maetzler, Patricia Sulzer, Malte Kampmeyer, Jos Prinzen, Markus A Hobert, Dominik Blum, Rob van Lummel, Silvia Del Din, Susanne Gräber, Daniela Berg, Inga Liepelt-Scarfone
BACKGROUND: For the early diagnosis of Parkinson disease dementia (PDD), objective home-based tools are needed to quantify even mild stages of dysfunction of the activities of daily living (ADL). OBJECTIVES: In this pilot study, home-based physical behavior was assessed to examine whether it is possible to distinguish mild cognitive impairment (PD-MCI) from PDD. METHODS: Fifty-five patients with mild to severe Parkinson disease (PD) participated in this cross-sectional study...
April 26, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/28428166/vascular-cognitive-impairment-in-a-memory-clinic-population-rationale-and-design-of-the-utrecht-amsterdam-clinical-features-and-prognosis-in-vascular-cognitive-impairment-trace-vci-study
#2
EDITORIAL
Jooske Marije Funke Boomsma, Lieza Geertje Exalto, Frederik Barkhof, Esther van den Berg, Jeroen de Bresser, Rutger Heinen, Huiberdina Lena Koek, Niels Daniël Prins, Philip Scheltens, Henry Chanoch Weinstein, Wiesje Maria van der Flier, Geert Jan Biessels
BACKGROUND: Vascular Cognitive Impairment (VCI) refers to cognitive dysfunction due to vascular brain injury, as a single cause or in combination with other, often neurodegenerative, etiologies. VCI is a broad construct that captures a heterogeneous patient population both in terms of cognitive and noncognitive symptoms and in terms of etiology and prognosis. This provides a challenge when applying this construct in clinical practice. OBJECTIVE: This paper presents the rationale and design of the TRACE-VCI study, which investigates the clinical features and prognosis of VCI in a memory clinic setting...
April 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28420323/study-protocol-insight-46-a-neuroscience-sub-study-of-the-mrc-national-survey-of-health-and-development
#3
Christopher A Lane, Thomas D Parker, Dave M Cash, Kirsty Macpherson, Elizabeth Donnachie, Heidi Murray-Smith, Anna Barnes, Suzie Barker, Daniel G Beasley, Jose Bras, David Brown, Ninon Burgos, Michelle Byford, M Jorge Cardoso, Ana Carvalho, Jessica Collins, Enrico De Vita, John C Dickson, Norah Epie, Miklos Espak, Susie M D Henley, Chandrashekar Hoskote, Michael Hutel, Jana Klimova, Ian B Malone, Pawel Markiewicz, Andrew Melbourne, Marc Modat, Anette Schrag, Sachit Shah, Nikhil Sharma, Carole H Sudre, David L Thomas, Andrew Wong, Hui Zhang, John Hardy, Henrik Zetterberg, Sebastien Ourselin, Sebastian J Crutch, Diana Kuh, Marcus Richards, Nick C Fox, Jonathan M Schott
BACKGROUND: Increasing age is the biggest risk factor for dementia, of which Alzheimer's disease is the commonest cause. The pathological changes underpinning Alzheimer's disease are thought to develop at least a decade prior to the onset of symptoms. Molecular positron emission tomography and multi-modal magnetic resonance imaging allow key pathological processes underpinning cognitive impairment - including β-amyloid depostion, vascular disease, network breakdown and atrophy - to be assessed repeatedly and non-invasively...
April 18, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28403621/examining-factors-affecting-caregiver-burden-a-comparison-of-frontotemporal-dementia-and-alzheimer-s-disease
#4
Özlem Küçükgüçlü, Burcu Akpınar Söylemez, Görsev Yener, Canan Demir Barutcu, Merve Aliye Akyol
This study was conducted to compare the caregiver burden with regard to Alzheimer's disease (AD) and frontotemporal dementia (FTD) and to determine the factors affecting the caregiver burden of patients with AD and FTD. A comparative descriptive study design was used. The sample consisted of 90 patients with AD and 44 patients with FTD and their caregivers. Sociodemographic questionnaire, Mini-Mental State Examination (MMSE), the Caregiver Burden Inventory (CBI), Neuropsychiatric Inventory (NPI), and Functional Activities Questionnaire (FAQ) were used...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28394770/the-biocard-index-a-summary-measure-to-predict-onset-of-mild-cognitive-impairment
#5
Ned Sacktor, Anja Soldan, Maura Grega, Leonie Farrington, Qing Cai, Mei-Cheng Wang, Rebecca F Gottesman, Raymond S Turner, Marilyn Albert
BACKGROUND: Changes in neuropsychological testing, neuroimaging, and cerebrospinal fluid may precede mild cognitive impairment (MCI). However, these markers are not routinely performed in outpatient clinical visits. OBJECTIVE: To evaluate whether a simple clinical index, consisting of questions given to patients and their informants, could predict the onset of symptoms of MCI among cognitively normal individuals. MATERIALS AND METHODS: Two hundred twenty-two participants in the BIOCARD study received a detailed history, physical examination, and neuropsychological testing annually...
April 7, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28387684/neuropsychological-subgroups-in-non-demented-parkinson-s-disease-a-latent-class-analysis
#6
Laura Brennan, Kathryn M Devlin, Sharon X Xie, Dawn Mechanic-Hamilton, Baochan Tran, Howard H Hurtig, Alice Chen-Plotkin, Lama M Chahine, James F Morley, John E Duda, David R Roalf, Nabila Dahodwala, Jacqueline Rick, John Q Trojanowski, Paul J Moberg, Daniel Weintraub
BACKGROUND: Methods to detect early cognitive decline and account for heterogeneity of deficits in Parkinson's disease (PD) are needed. Quantitative methods such as latent class analysis (LCA) offer an objective approach to delineate discrete phenotypes of impairment. OBJECTIVE: To identify discrete neurocognitive phenotypes in PD patients without dementia. METHODS: LCA was applied to a battery of 8 neuropsychological measures to identify cognitive subtypes in a cohort of 199 non-demented PD patients...
April 4, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28348918/correlation-of-visuospatial-ability-and-eeg-slowing-in-patients-with-parkinson-s-disease
#7
Dominique Eichelberger, Pasquale Calabrese, Antonia Meyer, Menorca Chaturvedi, Florian Hatz, Peter Fuhr, Ute Gschwandtner
Background. Visuospatial dysfunction is among the first cognitive symptoms in Parkinson's disease (PD) and is often predictive for PD-dementia. Furthermore, cognitive status in PD-patients correlates with quantitative EEG. This cross-sectional study aimed to investigate the correlation between EEG slowing and visuospatial ability in nondemented PD-patients. Methods. Fifty-seven nondemented PD-patients (17 females/40 males) were evaluated with a comprehensive neuropsychological test battery and a high-resolution 256-channel EEG was recorded...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28330539/-state-of-the-art-work-up-of-dementia-disorder
#8
Steen Gregers Hasselbalch
Early diagnosis of a dementia disorder is required for early support, treatment and information. A basic programme including history taking, somatic and neurological examination, blood screening and a structural scan will suffice in typical cases. For patients with uncertain or atypical symptoms or disease course, supplementary investigations are warranted, including biomarkers in cerebrospinal fluid, functional imaging and neuropsychological testing. Also, imaging of specific protein accumulations in Alzheimer's disease may serve to monitor disease progression and effects of interventions...
March 20, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28322777/preeclampsia-and-cognitive-impairment-later-in-life
#9
Julie A Fields, Vesna D Garovic, Michelle M Mielke, Kejal Kantarci, Muthuvel Jayachandran, Wendy M White, Alissa M Butts, Jonathan Graff-Radford, Brian D Lahr, Kent R Bailey, Virginia M Miller
BACKGROUND: Hypertension is a risk factor for cerebrovascular disease and cognitive impairment. Women with hypertensive episodes during pregnancy report variable neurocognitive changes within the first decade following the affected pregnancy. However, long-term follow-up of these women into their postmenopausal years has not been conducted. OBJECTIVE: The aim of this study was to examine whether women with a history of preeclampsia were at increased risk of cognitive decline 35-40 years after the affected pregnancy...
March 18, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28301848/predictors-of-reversion-from-mild-cognitive-impairment-to-normal-cognition
#10
Seema Y Pandya, Laura H Lacritz, Myron F Weiner, Martin Deschner, Fu L Woon
BACKGROUND/AIMS: Few studies have examined predictors of reversion from mild cognitive impairment (MCI) to normal cognition. We sought to identify baseline predictors of reversion, using the National Alzheimer's Coordinating Center Uniform Data Set, by comparing MCI individuals who reverted to normal cognition to those who progressed to dementia. METHODS: Participants (n = 1,208) meeting MCI criteria were evaluated at the baseline visit and 3 subsequent annual visits...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28260543/characteristics-and-health-conditions-of-a-group-of-nursing-home-patients-with-mental-physical-multimorbidity-the-mapping-study
#11
Anne M A van den Brink, Debby L Gerritsen, Miranda M H de Valk, Richard C Oude Voshaar, Raymond T C M Koopmans
BACKGROUND: Long-term care facilities have partly taken over the traditional asylum function of psychiatric hospitals and house an increasing group of patients with mental-physical multimorbidity (MPM). Little is known about the characteristics, behavior, and care dependency of these patients. This paper aims to describe these aspects. METHODS: Explorative, descriptive study among patients with MPM without dementia (n = 142), living in 17 geronto-psychiatric nursing home (NH) units across the Netherlands, stratified by those referred from mental healthcare services (MHS) and other healthcare services (OHS)...
March 6, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28235814/differentiating-cognitive-impairment-due-to-corticobasal-degeneration-and-alzheimer-disease
#12
Gregory S Day, Tae Sung Lim, Jason Hassenstab, Alison M Goate, Elizabeth A Grant, Catherine M Roe, Nigel J Cairns, John C Morris
OBJECTIVE: To identify clinical features that reliably differentiate individuals with cognitive impairment due to corticobasal degeneration (CBD) and Alzheimer disease (AD). METHODS: Clinical features were compared between individuals with autopsy-proven CBD (n = 17) and AD (n = 16). All individuals presented with prominent cognitive complaints and were evaluated annually with semistructured interviews, detailed neurologic examinations, and neuropsychological testing...
March 28, 2017: Neurology
https://www.readbyqxmd.com/read/28213293/relations-between-personality-changes-and-cerebrospinal-fluid-biomarkers-of-alzheimer-s-disease-pathology
#13
D Tautvydaitė, J P Antonietti, H Henry, A von Gunten, J Popp
Specific changes in personality profiles may represent early non-cognitive symptoms of Alzheimer's disease (AD). Evaluating the subject's personality changes may add significant clinical information, as well as help to better understand the interaction between personality change, cognitive decline, and cerebral pathology. With this study we aimed to describe the relationship between personality changes and cerebrospinal fluid (CSF) markers of AD pathology at early clinical stages of the disease. One hundred and ten subjects, of whom 66 cognitively impaired patients (57 with mild cognitive impairment (MCI), and 9 with mild dementia) and 44 healthy controls, had neuropsychological examination as well as lumbar puncture to determine concentrations of CSF biomarkers of AD pathology (amyloid beta1-42 (Aβ1-42), phosphorylated tau (ptau-181), and total-tau (tau))...
February 4, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28187125/aerobic-exercise-for-alzheimer-s-disease-a-randomized-controlled-pilot-trial
#14
Jill K Morris, Eric D Vidoni, David K Johnson, Angela Van Sciver, Jonathan D Mahnken, Robyn A Honea, Heather M Wilkins, William M Brooks, Sandra A Billinger, Russell H Swerdlow, Jeffrey M Burns
BACKGROUND: There is increasing interest in the role of physical exercise as a therapeutic strategy for individuals with Alzheimer's disease (AD). We assessed the effect of 26 weeks (6 months) of a supervised aerobic exercise program on memory, executive function, functional ability and depression in early AD. METHODS AND FINDINGS: This study was a 26-week randomized controlled trial comparing the effects of 150 minutes per week of aerobic exercise vs. non-aerobic stretching and toning control intervention in individuals with early AD...
2017: PloS One
https://www.readbyqxmd.com/read/28122474/screening-for-neurocognitive-impairment-in-hiv-positive-adults-aged-50-years-and-older-montreal-cognitive-assessment-relates-to-self-reported-and-clinician-rated-everyday-functioning
#15
P L Fazeli, K B Casaletto, E Paolillo, R C Moore, D J Moore, The Hnrp Group
As the HIV+ population ages, the risk for and need to screen for HIV-associated neurocognitive disorders (HAND) increases. The aim of this study is to determine the utility and ecological validity of the Montreal Cognitive Assessment (MoCA) among older HIV+ adults. A total of 100 HIV+ older adults aged 50 years or over completed a comprehensive neuromedical and neurocognitive battery, including the MoCA and several everyday functioning measures. The receiver operating characteristic curve indicates ≤26 as the optimal cut-off balancing sensitivity (84...
January 26, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28120733/prediction-of-post-stroke-dementia-using-ninds-csn-5-minute-neuropsychology-protocol-in-acute-stroke
#16
Jae-Sung Lim, Mi Sun Oh, Ju-Hun Lee, San Jung, Chulho Kim, Min Uk Jang, Sang-Hwa Lee, Yeo Jin Kim, Yerim Kim, Jaeseol Park, Yeonwook Kang, Kyung-Ho Yu, Byung-Chul Lee
BACKGROUND: The National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute neuropsychology protocol consists of only verbal tasks, and is proposed as a brief screening method for vascular cognitive impairment. We evaluated its feasibility within two weeks after stroke and ability to predict the development of post-stroke dementia (PSD) at 3 months after stroke. METHOD: We prospectively enrolled subjects with ischemic stroke within seven days of symptom onset who were consecutively admitted to 12 university hospitals...
January 25, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28116236/the-neural-correlates-and-clinical-characteristics-of-psychosis-in-the-frontotemporal-dementia-continuum-and-the-c9orf72-expansion
#17
Emma M Devenney, Ramon Landin-Romero, Muireann Irish, Michael Hornberger, Eneida Mioshi, Glenda M Halliday, Matthew C Kiernan, John R Hodges
OBJECTIVE: This present study aims to address the gap in the literature regarding the severity and underlying neural correlates of psychotic symptoms in frontotemporal dementia with and without the C9orf72 gene expansion. METHODS: Fifty-six patients with behavioural variant frontotemporal dementia (20 with concomitant amyotrophic lateral sclerosis) and 23 healthy controls underwent neuropsychological assessments, detailed clinical interview for assessment of psychosis symptoms, brain MRI and genetic testing...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28110464/alexithymia-in-people-with-subjective-cognitive-decline-mild-cognitive-impairment-and-mild-alzheimer-s-disease
#18
Mehmet Yuruyen, Fundan Engin Akcan, Gizem Cetiner Batun, Gozde Gultekin, Mesut Toprak, Hakan Yavuzer, Murat Emul
BACKGROUND: Behavioral and psychological symptoms are widely accepted as accelerator factors in progression to dementia. Although alexithymia is closely related to normal aging process and poor neurocognitive performance, alexithymia has not been included in these symptoms yet. AIMS: Here, we aimed to investigate alexithymia features in people with prominent clinical memory complaints. METHODS: The participants (n = 82) were classified into three groups as: subjective cognitive decline (n = 30), mild cognitive impairment (n = 27), and mild Alzheimer's disease (n = 25) after Mini-Mental State Examination, Clinical Dementia Rating Scale, neuropsychological test battery, Geriatric Depression Scale, and Hachinski Ischemic Scale...
January 21, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28106561/the-modified-frontal-behavioral-inventory-fbi-mod-for-patients-with-frontotemporal-lobar-degeneration-alzheimer-s-disease-and-mild-cognitive-impairment
#19
Noora-Maria Suhonen, Ilona Hallikainen, Tuomo Hänninen, Jari Jokelainen, Johanna Krüger, Anette Hall, Maria Pikkarainen, Hilkka Soininen, Anne M Remes
While behavioral symptoms are both early and prevalent features of behavioral variant frontotemporal dementia (bvFTD), they can be present in other types of dementia as well, including Alzheimer's disease (AD) and even mild cognitive impairment (MCI). The Frontal Behavioral Inventory (FBI) was specifically developed to capture the behavioral and personality changes in bvFTD; it has also been modified into a self-administered caregiver questionnaire (FBI-mod). We examined the utility of the FBI-mod in differentiating bvFTD (n = 26), primary progressive aphasia (PPA) (n = 7), AD (n = 53), and MCI (n = 50) patients, and investigated how the FBI-mod may be associated with neuropsychological measures...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28103593/executive-dysfunction-and-behavioral-symptoms-are-associated-with-deficits-in-instrumental-activities-of-daily-living-in-frontotemporal-dementia
#20
Negar Moheb, Mario F Mendez, Sarah A Kremen, Edmond Teng
BACKGROUND: Deficits in instrumental activities of daily living (ADLs) may be more prominent in behavioral variant frontotemporal dementia (bvFTD) than in nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) or semantic variant primary progressive aphasia (svPPA). It is uncertain whether frontotemporal dementia (FTD) subgroups exhibit different patterns and/or predictors of functional impairment. METHODS: We examined data from participants diagnosed with bvFTD (n = 607), svPPA (n = 132), and nfvPPA (n = 155) who were included in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) and assessed with the Functional Activities Questionnaire (FAQ)...
2017: Dementia and Geriatric Cognitive Disorders
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