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Neuropsychological symptoms of dementia

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https://www.readbyqxmd.com/read/29682229/cognitive-deficits-in-older-adults-with-mild-cognitive-impairment-in-a-two-year-follow-up-study
#1
Camila de Assis Faria, Heloisa Veiga Dias Alves, Eduarda Naidel Barboza E Barbosa, Helenice Charchat-Fichman
Characterizing cognitive decline in older adults with MCI over time is important to identify the cognitive profile of those who convert to dementia. Objective: This study examined the two-year cognitive trajectory of elderly adults diagnosed with MCI, from geriatrics and neurology outpatient clinics of a public hospital in Rio de Janeiro. Methods: 62 older adults with MCI were submitted to a neuropsychological battery and re-evaluated after two years. The Mann-Whitney U test was employed to assess differences between groups with respect to education, functioning, the Geriatric Depression Scale and diagnosis...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29662677/auto-antibodies-against-p-q-and-n-type-voltage-dependent-calcium-channels-mimicking-frontotemporal-dementia
#2
Kyan Younes, Lauren A Lepow, Cynthia Estrada, Paul E Schulz
The behavioral variant of frontotemporal dementia is usually a sporadic and progressive neurodegenerative disorder. Here, we report the subacute onset of a frontotemporal dementia phenotype with a treatable etiology. The patient has a history of rheumatoid arthritis, episcleritis, and thyroid eye disease on immunosuppressive therapy. He experienced a rapid personality change, including inappropriate behavior, which suggested frontotemporal dementia. Results of imaging and neuropsychological testing also suggested frontotemporal dementia...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29627938/longitudinal-cognitive-biomarkers-predicting-symptom-onset-in-presymptomatic-frontotemporal-dementia
#3
Lize C Jiskoot, Jessica L Panman, Lauren van Asseldonk, Sanne Franzen, Lieke H H Meeter, Laura Donker Kaat, Emma L van der Ende, Elise G P Dopper, Reinier Timman, Rick van Minkelen, John C van Swieten, Esther van den Berg, Janne M Papma
INTRODUCTION: We performed 4-year follow-up neuropsychological assessment to investigate cognitive decline and the prognostic abilities from presymptomatic to symptomatic familial frontotemporal dementia (FTD). METHODS: Presymptomatic MAPT (n = 15) and GRN mutation carriers (n = 31), and healthy controls (n = 39) underwent neuropsychological assessment every 2 years. Eight mutation carriers (5 MAPT, 3 GRN) became symptomatic. We investigated cognitive decline with multilevel regression modeling; the prognostic performance was assessed with ROC analyses and stepwise logistic regression...
April 7, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29614683/neuropsychological-predictors-of-long-term-10-years-mild-cognitive-impairment-stability
#4
Luísa Alves, Sandra Cardoso, João Maroco, Alexandre de Mendonça, Manuela Guerreiro, Dina Silva
BACKGROUND: Although the diagnosis of mild cognitive impairment (MCI) corresponds to a condition likely to progress to dementia, essentially Alzheimer's disease, longitudinal studies have shown that some patients may not convert to dementia and maintain the diagnosis of MCI even after many years. OBJECTIVES: To determine whether patients that maintain the diagnosis of MCI in the long term (10 years) are really stable or just declining slowly, and to identify clinical and neuropsychological characteristics associated with long-term stability...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29614643/caregiving-and-caregiver-burden-in-dementia-home-care-results-from-the-prospective-dementia-registry-prodem-of-the-austrian-alzheimer-society
#5
Gerhard Ransmayr, Philipp Hermann, Katharina Sallinger, Thomas Benke, Stephan Seiler, Peter Dal-Bianco, Josef Marksteiner, Michaela Defrancesco, Günter Sanin, Walter Struhal, Michael Guger, Milan Vosko, Karin Hagenauer, Riccarda Lehner, Andreas Futschik, Reinhold Schmidt
BACKGROUND: Comprehensive studies on caregiver burden (CB) of persons caring for dementia patients differ methodologically and show variable results. OBJECTIVE: Analysis of known and hypothesized factors of CB in home care of dementia patients. METHODS: Multicenter longitudinal study comprising 585 persons caring mostly for Alzheimer's disease patients (age median 77.25 years, Mini-Mental State Examination raw score median 23) using the Zarit Caregiver Burden interview (CBI)...
March 29, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29614640/diagnostic-value-of-diffusion-tensor-imaging-and-positron-emission-tomography-in-early-stages-of-frontotemporal-dementia
#6
Julia Krämer, Gero Lueg, Patrick Schiffler, Alexis Vrachimis, Matthias Weckesser, Christian Wenning, Matthias Pawlowski, Andreas Johnen, Anja Teuber, Heike Wersching, Sven G Meuth, Thomas Duning
BACKGROUND: Due to suboptimal sensitivity and specificity of structural and molecular neuroimaging tools, the diagnosis of behavioral variant frontotemporal dementia (bvFTD) remains challenging. OBJECTIVE: Investigation of the sensitivity of diffusion tensor imaging (DTI) and fluorodeoxyglucose positron emission tomography (FDG-PET) to detect cerebral alterations in early stages of bvFTD despite inconspicuous conventional MRI. METHODS: Thirty patients with early stages of bvFTD underwent a detailed neuropsychological examination, cerebral 3T MRI with DTI analysis, and FDG-PET...
March 28, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29606956/cognitive-blackouts-in-mild-cognitive-impairment-and-alzheimer-s-dementia
#7
Georg Adler, Agnies Marczak, Jana Binder
Background: Cognitive blackouts, e.g. moments of amnesia, disorientation, or perplexity may be an early sign of incipient Alzheimer's dementia (AD). A short questionnaire, the checklist for cognitive blackouts (CCB), was evaluated cross-sectionally in users of a memory clinic. Methods: The CCB was performed in 130 subjects, who further underwent a neuropsychological and clinical examination. Subjective memory impairment and depressive symptoms were assessed. Differences in the CCB score between diagnostic groups and relationships with cognitive performance, depression, and subjective memory impairment were analyzed...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29604978/neuropathogenesis-of-human-immunodeficiency-virus-infection
#8
Brady Sillman, Christopher Woldstad, Joellyn Mcmillan, Howard E Gendelman
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) remain a common end-organ manifestation of viral infection. Subclinical and mild symptoms lead to neurocognitive and behavioral abnormalities. These are associated, in part, with viral penetrance and persistence in the central nervous system. Infections of peripheral blood monocytes, macrophages, and microglia are the primary drivers of neuroinflammation and neuronal impairments. While current antiretroviral therapy (ART) has reduced the incidence of HIV-associated dementia, milder forms of HAND continue...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29593630/parkinson-s-disease-dementia-and-dementia-with-lewy-bodies-have-similar-neuropsychological-profiles
#9
Georgina M Aldridge, Allison Birnschein, Natalie L Denburg, Nandakumar S Narayanan
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are common causes of dementia worldwide. Although considered separate entities based on the relative temporal onset of motor symptoms vs. diagnosis of dementia, it is unknown if these diseases truly have distinct cognitive profiles. We hypothesized that patients divided into PDD and DLB categories strictly by temporal criteria would have different neuropsychological profiles. We investigated this question via neuropsychological testing of PDD and DLB patients at the University of Iowa...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29526855/potential-benefits-of-a-cognitive-training-program-in-mild-cognitive-impairment-mci
#10
Nuria Mendoza Laiz, Sagrario Del Valle Díaz, Natalia Rioja Collado, Javier Gomez-Pilar, Roberto Hornero
BACKGROUND: Dementia is a disease that is constantly evolving in older people. Its diverse symptoms appear with varying degrees of severity affecting the daily life of those who suffer from it. The rate in which dementia progresses depends on different aspects of the treatment, chosen to try to control and slow down the development of the illness. OBJECTIVE: The aim of this study is to assess the effectiveness of cognitive training through a Brain Computer Interface (BCI) and the NeuronUp platform in two age groups whose MMSE is between 18-23 MCI (mild dementia)...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29520325/olfactory-and-imaging-features-in-atypical-alzheimer-s-disease
#11
Zhang Huihong, Wang Pan, Zhang Chunfeng, Wang Yan, Zhang Hui, Cai Li, Zhou Yuying
Objectives: Cognition and speech disorders are the most common symptoms of dementia in neurodegenerative disease. Here, we present a detailed clinical evaluation of a case of logopenic variant of primary progressive aphasia (lv-PPA), an atypical form of Alzheimer disease (AD), including cognitive testing over time, brain imaging, electrophysiology, and tests of olfactory function. Case report: We present the case of a 58-year-old man suffering from progressive language difficulties who was finally diagnosed with lv-PPA...
2018: Translational Neuroscience
https://www.readbyqxmd.com/read/29509993/the-need-of-an-extensive-neuropsychological-assessment-for-a-reliable-diagnosis-of-mild-cognitive-impairment-in-patients-with-parkinson-s-disease
#12
Antonio Daniele, Giordano Lacidogna
Among non-motor symptoms of Parkinson's disease (PD), cognitive and behavioural symptoms may precede the appearance of motor symptoms and become increasingly severe over disease progression. In patients with PD, mild cognitive impairment (PD-MCI) refers to a condition characterized by variable degrees of cognitive dysfunction, which does not significantly interfere with independence in daily living activities. PD-MCI may occur in at least 9% of patients in early disease stages1 , is a risk factor for PD dementia (PDD), and may present with a variety of patterns of impairment across several cognitive domains (executive functions, attention/working memory, episodic memory, visuospatial skills, language)...
March 6, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29501411/social-cognition-differentiates-behavioral-variant-frontotemporal-dementia-from-other-neurodegenerative-diseases-and-psychiatric-disorders
#13
Flora Gossink, Sigfried Schouws, Welmoed Krudop, Philip Scheltens, Max Stek, Yolande Pijnenburg, Annemiek Dols
OBJECTIVE: Although deficits in social cognition are established as core features in behavioral variant frontotemporal dementia (bvFTD), it remains unresolved if impaired social cognition distinguishes bvFTD from the broad differential diagnoses in clinical practice. Our aim was to study whether social cognition discriminates bvFTD from other neurodegenerative diseases and psychiatric disorders in patients presenting with late-onset frontal symptoms. Next, we studied the association of social cognition with frontal symptoms and cognitive functioning...
February 1, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29488192/-apathy-depression-and-cognitive-functioning-in-patients-with-mci-and-dementia
#14
Robin Vloeberghs, Esther M Opmeer, Peter P De Deyn, Sebastiaan Engelborghs, Ellen E De Roeck
BACKGROUND: In dementia, apathy and depression are often seen as one disorder because of the many overlapping symptoms. However, for therapy a correct differentiation is essential. Moreover, apathy and depression are likely both associated with different cognitive deficits and progression of the disease. In this research we give an overview of cognitive domains associated with apathy and depression in MCI patients and report how often both disorders occur in a population sample. METHOD: We administered the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to 117 cognitively healthy controls (GC), 97 patients with mild cognitive impairment (MCI) and 50 patients with dementia (DEM)...
February 27, 2018: Tijdschrift Voor Gerontologie en Geriatrie
https://www.readbyqxmd.com/read/29439333/risk-of-conversion-to-dementia-in-a-mild-behavioral-impairment-group-compared-to-a-psychiatric-group-and-to-a-mild-cognitive-impairment-group
#15
Fernando E Taragano, Ricardo F Allegri, Silvina L Heisecke, María I Martelli, Mónica L Feldman, Viviana Sánchez, Virginia A García, Graciela Tufro, Diego M Castro, Patricio Perez Leguizamón, Verónica Guelar, Eva Ruotolo, Cecilia Zegarra, Carol Dillon
BACKGROUND: There is insufficient available information on behavioral changes in the absence of cognitive impairment as factors increasing the risk of conversion to dementia. OBJECTIVE: To observe and analyze patients with mild behavioral impairment (MBI), mild cognitive impairment (MCI), and a psychiatry group (PG) to compare the risk of progression to dementia. METHODS: From 677 initially assessed ≥60-year-old patients, a series of 348 patients was studied for a five-year period until censoring or conversion to dementia: 96 with MBI, 87 with MCI, and 165 with general psychiatry disorders, including 4 subgroups: Anxiety, Depression, Psychosis and Others...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29438037/tau-negative-amnestic-dementia-masquerading-as-alzheimer-disease-dementia
#16
Hugo Botha, William G Mantyh, Jonathan Graff-Radford, Mary M Machulda, Scott A Przybelski, Heather J Wiste, Matthew L Senjem, Joseph E Parisi, Ronald C Petersen, Melissa E Murray, Bradley F Boeve, Val J Lowe, David S Knopman, Clifford R Jack, David T Jones
OBJECTIVE: To describe the phenomenon of tau-negative amnestic dementia mimicking Alzheimer disease (AD) clinically and radiologically and to highlight the importance of biomarkers in AD research. METHODS: Eight participants with amnestic mild cognitive impairment or AD dementia were evaluated by a behavioral neurologist and had a standardized neuropsychological battery performed. All participants completed structural (MRI) and molecular (amyloid and tau PET) imaging...
March 13, 2018: Neurology
https://www.readbyqxmd.com/read/29381739/impaired-memory-is-more-closely-associated-with-brain-beta-amyloid-than-leukoaraiosis-in-hypertensive-patients-with-cognitive-symptoms
#17
Eric E Smith, Alona Muzikansky, Cheryl R McCreary, Saima Batool, Anand Viswanathan, Bradford C Dickerson, Keith Johnson, Steven M Greenberg, Deborah Blacker
BACKGROUND: Hypertension is the strongest modifiable risk factor for subcortical ischemic changes and is also a risk factor for Alzheimer's dementia. We used neuroimaging to investigate the pathological basis of early cognitive symptoms in patients with hypertension. METHODS: In this cross-sectional cohort study 67 patients age >60 years with hypertension and Clinical Dementia Rating scale score of 0.5 without dementia, and without history of symptomatic stroke, underwent MRI for measurement of subcortical vascular changes and positron emission tomography (PET) scan with Pittsburgh Compound B (PiB-PET) to detect beta-amyloid deposition...
2018: PloS One
https://www.readbyqxmd.com/read/29376872/characteristics-of-cognitively-normal-mexican-americans-with-cognitive-complaints
#18
James R Hall, April Wiechmann, Leigh A Johnson, Melissa Edwards, Sid E O'Bryant
BACKGROUND: Subjective cognitive complaints in cognitively normal adults have been linked to later cognitive decline and dementia. Research on the characteristics of this group has been conducted on a variety of clinical and community-based populations. The current study focuses on the rapidly expanding population of Mexican-American elders. OBJECTIVE: The objective of the study is the determination of characteristics of cognitively normal Mexican-Americans with cognitive complaints...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29362011/neuropsychiatric-symptoms-and-cognitive-profile-in-mild-cognitive-impairment-with-lewy-bodies
#19
Paul C Donaghy, John-Paul Taylor, John T O'Brien, Nicola Barnett, Kirsty Olsen, Sean J Colloby, Jim Lloyd, George Petrides, Ian G McKeith, Alan J Thomas
BACKGROUND: The accurate clinical characterisation of mild cognitive impairment (MCI) is becoming increasingly important. The aim of this study was to compare the neuropsychiatric symptoms and cognitive profile of MCI with Lewy bodies (MCI-LB) with Alzheimer's disease MCI (MCI-AD). METHODS: Participants were ⩾60 years old with MCI. Each had a thorough clinical and neuropsychological assessment and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computed tomography FP-CIT SPECT)...
January 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29328983/social-and-cognitive-control-skills-in-long-life-occupation-activities-modulate-the-brain-reserve-in-the-behavioural-variant-of-frontotemporal-dementia
#20
Alessandra Dodich, Giulia Carli, Chiara Cerami, Sandro Iannaccone, Giuseppe Magnani, Daniela Perani
BACKGROUND: Cognitive reserve may delay disease onset and mitigate symptoms presentation in neurodegenerative dementias. Although high occupation levels can be associated with higher cognitive reserve in the behavioural variant of frontotemporal dementia (bvFTD), it was never addressed how specific occupation profiles involving social interaction, executive and attention abilities can modulate neural reserve in bvFTD. MATERIALS AND METHODS: We retrospectively included thirty-seven bvFTD patients with clinical-neuropsychological and FDG-PET brain metabolic data...
February 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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