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Neuropsychological symptoms of dementia

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https://www.readbyqxmd.com/read/27869586/hyperfamiliarity-in-amnestic-and-vascular-mild-cognitive-impairment
#1
Pei Shi Chia, Shahul Hameed, Kok Pin Yong, Ling Ling Chan, Simon Kang Seng Ting
OBJECTIVE: Hyperfamiliarity is a phenomenon where new stimuli are perceived as familiar. Previous studies have demonstrated familiarity disorder in mild cognitive impairment (MCI), but mostly from the perspective of a neuropsychological approach, and the exact correlation of MCI aetiologies with the phenomenon remains uncertain. Based on current evidence suggesting a frontal-subcortical pathway contributing to familiarity processing, we hypothesize that individuals with a vascular aetiology of MCI will likely suffer more familiarity deficits...
November 21, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27843319/effects-of-multiple-training-modalities-in-patients-with-alzheimer-s-disease-a-pilot-study
#2
Shu-Yu Tai, Chia-Ling Hsu, Shu-Wan Huang, Tzu-Chiao Ma, Wen-Chien Hsieh, Yuan-Han Yang
OBJECTIVE: This pilot study investigated the effects of multiple training modalities on cognition, neuropsychiatric symptoms, caregivers' burden, and quality of life in patients with Alzheimer's disease (AD). PATIENTS AND METHODS: This intervention study was conducted in 24 patients with AD aged ≥65 years with a Clinical Dementia Rating (CDR) score of 0.5-1. The patients were assigned to receive multiple training modalities (1 hour for each training: Tai Chi, calligraphy, and drawing) over a 6-week period in either the experimental group (n=14) or the comparison group (n=10)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27831627/-pathological-gambling-and-epilepsy-in-patients-with-frontotemporal-dementia-two-case-reports
#3
Sheila Castro-Suarez, Peggy Martinez, María Meza
Frontotemporal dementia is a neurodegenerative disorder of which the behavioral variant is most common. This condition is currently considered the most common cause of dementia in people younger than 60 years. Here, we present two unrelated cases in which the typical symptoms were cognitive and behavioral progressive deterioration and psychiatric disorders such as disinhibition, impulsive acts, apathy, lack of empathy, stereotypies, and changes in eating habits. The first case exhibited pathological gambling as the initial symptom and resided in a psychiatric facility for a year...
July 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/27829318/cognitive-effects-of-rasagiline-in-mild-to-moderate-stage-parkinson-s-disease-without-dementia
#4
Laura L Frakey, Joseph H Friedman
The authors studied the effects of rasagiline on cognition in a sample of 50 nondemented patients with mild to moderate Parkinson's disease (PD) using a double-blind, placebo controlled design. Cognition and motor symptoms were assessed at baseline and after 6 months of receiving either rasagiline or placebo. Participants receiving rasagiline showed improvement in their motor symptoms of PD compared to participants receiving placebo. No significant changes in performance on neuropsychological measures of cognition were observed between the groups...
November 10, 2016: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27819401/-clinical-usefulness-and-psychometric-properties-of-the-cambridge-behavioural-inventory
#5
R Fernandez-Martinez, E Kokoulina, E Carballido-Araujo, I Garcia-Fuertes, O Gutierrez-Martinez, F Santiago-Lopez, P Vazquez-Batan
INTRODUCTION: An important area in neuropsychological assessment is that of psychological and behavioural symptoms. The Cambridge Behavioural Inventory (CBI) is a self-report measure aimed at relatives which takes account of a wide range of behavioural symptoms that may occur during the course of neurological diseases. The main objective of the study is to test the clinical usefulness of its Spanish adaptation. SUBJECTS AND METHODS: The CBI was completed by 215 members of kin of patients referred from neurology and psychiatry services...
November 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27809791/the-parkin-play-study-protocol-of-a-phase-ii-randomized-controlled-trial-to-assess-the-effects-of-a-health-game-on-cognition-in-parkinson-s-disease
#6
Sjors C F van de Weijer, Annelien A Duits, Bastiaan R Bloem, Roy P Kessels, Jacobus F A Jansen, Sebastian Köhler, Gerrit Tissingh, Mark L Kuijf
BACKGROUND: In Parkinson's disease (PD), cognitive impairment is an important non-motor symptom heralding the development of dementia. Effective treatments to slow down the rate of cognitive decline in PD patients with mild cognitive impairment are lacking. Here, we describe the design of the Parkin'Play study, which assesses the effects of a cognitive health game intervention on cognition in PD. METHODS/DESIGN: This study is a multicentre, phase-II, open-randomized clinical trial that aims to recruit 222 PD patients with mild cognitive impairment...
November 3, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27802001/correlation-between-overactive-bladder-symptom-score-and-neuropsychological-parameters-in-alzheimer-s-disease-patients-with-lower-urinary-tract-symptom
#7
Ha Bum Jung, Don Kyoung Choi, Seong Ho Lee, Sung Tae Cho, Hae Ri Na, Moon Ho Park
PURPOSE: To examine an association between the overactive bladder symptom score (OABSS) and neuropsychological parameters. Moreover, we investigate the factors that affect each item in the questionnaire. MATERIALS AND METHODS: A total of 376 patients (males: 184; females: 192) with probable Alzheimer's disease (AD) were recruited. Cognitive testing was conducted using the Mini Mental Status Examination (MMSE), Clinical Dementia Rating (CDR) scale, Global Deterioration Scale (GDS), and Barthel Activities of Daily Living (ADL)...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27761124/executive-cognitive-functioning-and-cardiovascular-autonomic-regulation-in-a-population-based-sample-of-working-adults
#8
Cecilia U D Stenfors, Linda M Hanson, Töres Theorell, Walter S Osika
Objective: Executive cognitive functioning is essential in private and working life and is sensitive to stress and aging. Cardiovascular (CV) health factors are related to cognitive decline and dementia, but there is relatively few studies of the role of CV autonomic regulation, a key component in stress responses and risk factor for cardiovascular disease (CVD), and executive processes. An emerging pattern of results from previous studies suggest that different executive processes may be differentially associated with CV autonomic regulation...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27723823/grey-and-white-matter-clinico-anatomical-correlates-of-disinhibition-in-neurodegenerative-disease
#9
Alexander Frizell Santillo, Karl Lundblad, Markus Nilsson, Maria Landqvist Waldö, Danielle van Westen, Jimmy Lätt, Erik Blennow Nordström, Susanna Vestberg, Olof Lindberg, Christer Nilsson
Disinhibition is an important symptom in neurodegenerative diseases. However, the clinico-anatomical underpinnings remain controversial. We explored the anatomical correlates of disinhibition in neurodegenerative disease using the perspective of grey and white matter imaging. Disinhibition was assessed with a neuropsychological test and a caregiver information-based clinical rating scale in 21 patients with prefrontal syndromes due to behavioural variant frontotemporal dementia (n = 12) or progressive supranuclear palsy (n = 9), and healthy controls (n = 25)...
2016: PloS One
https://www.readbyqxmd.com/read/27720663/performance-based-assessment-of-instrumental-activities-of-daily-living-validation-of-the-sydney-test-of-activities-of-daily-living-in-memory-disorders-stam
#10
Simone Reppermund, Rachael C Birch, John D Crawford, Jacqueline Wesson, Brian Draper, Nicole A Kochan, Julian N Trollor, Katharina Luttenberger, Henry Brodaty, Perminder S Sachdev
OBJECTIVES: The distinction between dementia and mild cognitive impairment (MCI) relies upon the evaluation of independence in instrumental activities of daily living (IADL). Self- and informant reports are prone to bias. Clinician-based performance tests are limited by long administration times, restricted access, or inadequate validation. To close this gap, we developed and validated a performance-based measure of IADL, the Sydney Test of Activities of Daily Living in Memory Disorders (STAM)...
October 6, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27717954/specific-features-of-executive-dysfunction-in-alzheimer-type-mild-dementia-based-on-computerized-cambridge-neuropsychological-test-automated-battery-cantab-test-results
#11
Jurgita Kuzmickienė, Gintaras Kaubrys
BACKGROUND The primary manifestation of Alzheimer's disease (AD) is decline in memory. Dysexecutive symptoms have tremendous impact on functional activities and quality of life. Data regarding frontal-executive dysfunction in mild AD are controversial. The aim of this study was to assess the presence and specific features of executive dysfunction in mild AD based on Cambridge Neuropsychological Test Automated Battery (CANTAB) results. MATERIAL AND METHODS Fifty newly diagnosed, treatment-naïve, mild, late-onset AD patients (MMSE ≥20, AD group) and 25 control subjects (CG group) were recruited in this prospective, cross-sectional study...
October 8, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27695413/adult-body-height-is-a-good-predictor-of-different-dimensions-of-cognitive-function-in-aged-individuals-a-cross-sectional-study
#12
Vitor H Pereira, Patrício S Costa, Nadine C Santos, Pedro G Cunha, Margarida Correia-Neves, Joana A Palha, Nuno Sousa
Background: Adult height, weight, and adiposity measures have been suggested by some studies to be predictors of depression, cognitive impairment, and dementia. However, the presence of confounding factors and the lack of a thorough neuropsychological evaluation in many of these studies have precluded a definitive conclusion about the influence of anthropometric measures in cognition and depression. In this study we aimed to assess the value of height, weight, and abdominal perimeter to predict cognitive impairment and depressive symptoms in aged individuals...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27693188/a-common-challenge-in-older-adults-classification-overlap-and-therapy-of-depression-and-dementia
#13
Thomas Leyhe, Charles F Reynolds, Tobias Melcher, Christoph Linnemann, Stefan Klöppel, Kaj Blennow, Henrik Zetterberg, Bruno Dubois, Simone Lista, Harald Hampel
Late-life depression is frequently associated with cognitive impairment. Depressive symptoms are often associated with or even precede a dementia syndrome. Moreover, depressive disorders increase the risk of persistence for mild cognitive impairment and dementia. Here, we present both the current state of evidence and future perspectives regarding the integration and value of clinical assessments, neuropsychological, neurochemical, and neuroimaging biomarkers for the etiological classification of the dementia versus the depression syndrome and for the prognosis of depression relating to dementia risk...
September 28, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/27688200/cognitive-and-psychiatric-outcome-3-years-after-globus-pallidus-pars-interna-or-subthalamic-nucleus-deep-brain-stimulation-for-parkinson-s-disease
#14
Judith A Boel, Vincent J J Odekerken, Ben A Schmand, Gert J Geurtsen, Danielle C Cath, Martijn Figee, Pepijn van den Munckhof, Rob J de Haan, P Richard Schuurman, Rob M A de Bie
BACKGROUND: Effects on non-motor symptoms, mainly cognitive and psychiatric side effects, could influence the decision for either globus pallidus pars interna (GPi) or subthalamic nucleus (STN) deep brain stimulation (DBS) for patients with Parkinson's disease (PD). OBJECTIVE: 1) To compare cognitive and psychiatric outcomes 3 years after GPi DBS versus STN DBS, and 2) to report on occurrence of suicidal ideation, psychiatric diagnoses, social functioning, and marital satisfaction 3 years after DBS...
September 19, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27639684/shared-neural-correlates-of-limb-apraxia-in-early-stages-of-alzheimer-s-dementia-and-behavioural-variant-frontotemporal-dementia
#15
Andreas Johnen, Lisa Brandstetter, Christian Kärgel, Heinz Wiendl, Hubertus Lohmann, Thomas Duning
Limb apraxia denotes a cognitive impairment of gesture production. Lesion studies in patients with stroke point towards distinct neural processing streams for limb imitation and object-pantomime within left parietal and temporal cortex, respectively. Despite its frequent occurrence as an early symptom in both, Alzheimer's dementia (AD) and behavioural variant frontotemporal dementia (bvFTD), neural correlates of limb apraxia within these patient groups remain unexplored. Using voxel-based morphometry and multiple regression models, associations between limb apraxia and gray matter (GM) volume were investigated in 36 dementia patients (18 AD, 18 bvFTD) in early disease stages...
August 26, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27576786/the-impact-of-depressive-symptoms-on-health-related-quality-of-life-in-patients-with-subjective-cognitive-decline-mild-cognitive-impairment-and-alzheimer-s-disease
#16
G Pusswald, D Moser, M Pflüger, A Gleiss, E Auff, E Stögmann, P Dal-Bianco, J Lehrner
BACKGROUND: Health-related quality of life (HRQOL) is an important issue in the context of dementia care. The purpose of this study was to investigate the association between HRQOL and depressive symptoms in patients with subjective cognitive decline (SCD) and subtypes of mild cognitive impairment (MCI) and Alzheimer´s disease (AD). METHODS: In this cross-sectional, observational study, a control group and four experimental groups (SCD, non-amnestic MCI, amnesticMCI, AD) were compared...
August 31, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27570344/neuropsychiatric-symptoms-in-a-cohort-of-patients-with-frontotemporal-dementia-our-experience
#17
Sadanandavalli Retnaswami Chandra, Thomas Gregor Issac, Suresh Kumar Korada, Karru Venkata Ravi Teja, Mariamma Philip
INTRODUCTION: About 20-50% of relatively young onset dementia belongs to frontotemporal type. Most of these patients are diagnosed as psychiatric illness as their memory and instrumental activities of daily living remain unaltered till late and most of these patients do not qualify for dementia by the Diagnostic and Statistical Manual of Mental Disorders-IV criteria. In this study, we analyzed the behavioral symptoms in our patients with radiologically and neuropsychologically proven as probable behavioral variant of frontotemporal dementia (FTD)...
July 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27567867/first-symptoms-and-neurocognitive-correlates-of-behavioral-variant-frontotemporal-dementia
#18
Hernando Santamaría-García, Pablo Reyes, Adolfo García, Sandra Baéz, Angela Martinez, José Manuel Santacruz, Andrea Slachevsky, Mariano Sigman, Diana Matallana, Agustín Ibañez
BACKGROUND: Previous works highlight the neurocognitive differences between apathetic and disinhibited clinical presentations of the behavioral variant frontotemporal dementia (bvFTD). However, little is known regarding how the early presentation (i.e., first symptom) is associated to the neurocognitive correlates of the disease's clinical presentation at future stages of disease. OBJECTIVES: We analyzed the neurocognitive correlates of patients with bvFTD who debuted with apathy or disinhibition as first symptom of disease...
October 4, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27531211/-late-onset-depression-pathophysiology-diagnostics-and-treatment
#19
S Notzon, J Alferink, V Arolt
Late-onset depression (LOD) is defined as depression manifesting for the first time in later life. Up to now, there has been no exact definition of the lower age limit for LOD. Psychopathological symptoms of LOD do not fundamentally differ from depression in other phases of life; however, cognitive deficits are typically more pronounced. The LOD is associated with an increased risk of developing dementia. Imaging studies show reduction in gray matter volume and white matter lesions caused by vascular diseases...
September 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27509183/older-rural-and-urban-dwelling-appalachian-adults-with-mild-cognitive-impairment
#20
Meghan K Mattos, Beth E Snitz, Jennifer H Lingler, Lora E Burke, Lorraine M Novosel, Susan M Sereika
PURPOSE: Mild cognitive impairment (MCI) is a well-recognized risk state for Alzheimer's disease and other dementias. MCI is rapidly increasing among older adults in general and has not yet been examined in older adults within the Appalachian region. Our objective was to compare MCI symptom severity among older rural and urban Appalachian adults with MCI at an initial neuropsychological testing visit. METHODS: A cross-sectional, descriptive study of older Appalachian adults with MCI was conducted using data from the National Alzheimer's Coordinating Center Uniform Data Set...
August 10, 2016: Journal of Rural Health
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