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Neuropsychological symptoms of dementia

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https://www.readbyqxmd.com/read/29439333/risk-of-conversion-to-dementia-in-a-mild-behavioral-impairment-group-compared-to-a-psychiatric-group-and-to-a-mild-cognitive-impairment-group
#1
Fernando E Taragano, Ricardo F Allegri, Silvina L Heisecke, María I Martelli, Mónica L Feldman, Viviana Sánchez, Virginia A García, Graciela Tufro, Diego M Castro, Patricio Perez Leguizamón, Verónica Guelar, Eva Ruotolo, Cecilia Zegarra, Carol Dillon
BACKGROUND: There is insufficient available information on behavioral changes in the absence of cognitive impairment as factors increasing the risk of conversion to dementia. OBJECTIVE: To observe and analyze patients with mild behavioral impairment (MBI), mild cognitive impairment (MCI), and a psychiatry group (PG) to compare the risk of progression to dementia. METHODS: From 677 initially assessed ≥60-year-old patients, a series of 348 patients was studied for a five-year period until censoring or conversion to dementia: 96 with MBI, 87 with MCI, and 165 with general psychiatry disorders, including 4 subgroups: Anxiety, Depression, Psychosis and Others...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29438037/tau-negative-amnestic-dementia-masquerading-as-alzheimer-disease-dementia
#2
Hugo Botha, William G Mantyh, Jonathan Graff-Radford, Mary M Machulda, Scott A Przybelski, Heather J Wiste, Matthew L Senjem, Joseph E Parisi, Ronald C Petersen, Melissa E Murray, Bradley F Boeve, Val J Lowe, David S Knopman, Clifford R Jack, David T Jones
OBJECTIVE: To describe the phenomenon of tau-negative amnestic dementia mimicking Alzheimer disease (AD) clinically and radiologically and to highlight the importance of biomarkers in AD research. METHODS: Eight participants with amnestic mild cognitive impairment or AD dementia were evaluated by a behavioral neurologist and had a standardized neuropsychological battery performed. All participants completed structural (MRI) and molecular (amyloid and tau PET) imaging...
February 7, 2018: Neurology
https://www.readbyqxmd.com/read/29381739/impaired-memory-is-more-closely-associated-with-brain-beta-amyloid-than-leukoaraiosis-in-hypertensive-patients-with-cognitive-symptoms
#3
Eric E Smith, Alona Muzikansky, Cheryl R McCreary, Saima Batool, Anand Viswanathan, Bradford C Dickerson, Keith Johnson, Steven M Greenberg, Deborah Blacker
BACKGROUND: Hypertension is the strongest modifiable risk factor for subcortical ischemic changes and is also a risk factor for Alzheimer's dementia. We used neuroimaging to investigate the pathological basis of early cognitive symptoms in patients with hypertension. METHODS: In this cross-sectional cohort study 67 patients age >60 years with hypertension and Clinical Dementia Rating scale score of 0.5 without dementia, and without history of symptomatic stroke, underwent MRI for measurement of subcortical vascular changes and positron emission tomography (PET) scan with Pittsburgh Compound B (PiB-PET) to detect beta-amyloid deposition...
2018: PloS One
https://www.readbyqxmd.com/read/29376872/characteristics-of-cognitively-normal-mexican-americans-with-cognitive-complaints
#4
James R Hall, April Wiechmann, Leigh A Johnson, Melissa Edwards, Sid E O'Bryant
BACKGROUND: Subjective cognitive complaints in cognitively normal adults have been linked to later cognitive decline and dementia. Research on the characteristics of this group has been conducted on a variety of clinical and community-based populations. The current study focuses on the rapidly expanding population of Mexican-American elders. OBJECTIVE: The objective of the study is the determination of characteristics of cognitively normal Mexican-Americans with cognitive complaints...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29362011/neuropsychiatric-symptoms-and-cognitive-profile-in-mild-cognitive-impairment-with-lewy-bodies
#5
Paul C Donaghy, John-Paul Taylor, John T O'Brien, Nicola Barnett, Kirsty Olsen, Sean J Colloby, Jim Lloyd, George Petrides, Ian G McKeith, Alan J Thomas
BACKGROUND: The accurate clinical characterisation of mild cognitive impairment (MCI) is becoming increasingly important. The aim of this study was to compare the neuropsychiatric symptoms and cognitive profile of MCI with Lewy bodies (MCI-LB) with Alzheimer's disease MCI (MCI-AD). METHODS: Participants were ⩾60 years old with MCI. Each had a thorough clinical and neuropsychological assessment and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computed tomography FP-CIT SPECT)...
January 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29328983/social-and-cognitive-control-skills-in-long-life-occupation-activities-modulate-the-brain-reserve-in-the-behavioural-variant-of-frontotemporal-dementia
#6
Alessandra Dodich, Giulia Carli, Chiara Cerami, Sandro Iannaccone, Giuseppe Magnani, Daniela Perani
BACKGROUND: Cognitive reserve may delay disease onset and mitigate symptoms presentation in neurodegenerative dementias. Although high occupation levels can be associated with higher cognitive reserve in the behavioural variant of frontotemporal dementia (bvFTD), it was never addressed how specific occupation profiles involving social interaction, executive and attention abilities can modulate neural reserve in bvFTD. MATERIALS AND METHODS: We retrospectively included thirty-seven bvFTD patients with clinical-neuropsychological and FDG-PET brain metabolic data...
December 19, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29307083/in-thai-nationals-the-apoe4-allele-affects-multiple-domains-of-neuropsychological-biobehavioral-and-social-functioning-thereby-contributing-to-alzheimer-s-disorder-while-the-apoe3-allele-protects-against-neuropsychiatric-symptoms-and-psychosocial-deficits
#7
Sookjaroen Tangwongchai, Thitiporn Supasitthumrong, Solaphat Hemrunroj, Chavit Tunvirachaisakul, Phenphichcha Chuchuen, Natnicha Houngngam, Thiti Snabboon, Ittipol Tawankanjanachot, Yuthachai Likitchareon, Kamman Phanthumchindad, Michael Maes
The apolipoprotein E epsilon 4 (ApoE4) allele is the strongest genetic risk factor for Alzheimer's disorder (AD) and is associated with semantic and episodic memory deficits. The aim of this study was to examine the associations between ApoE alleles (E2, E3, E4) and genotypes and neuropsychological tests, behavioral functions, and dementia symptoms as assessed using Consortium to Establish a Registry for Alzheimer's Disease (CERAD). This study included 60 patients with Alzheimer's disorder (AD), 60 with mild cognitive disorder (MCI), and 62 normal volunteers...
January 6, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29298174/reduced-walking-speed-in-subjective-and-mild-cognitive-impairment-a-cross-sectional-study
#8
Mari Kalland Knapstad, Ole Martin Steihaug, Mona Kristin Aaslund, Arne Nakling, Ingvill Fjell Naterstad, Tormod Fladby, Dag Aarsland, Lasse Melvaer Giil
BACKGROUND AND PURPOSE: Walking speed is reduced in people with dementia, but less is known about predementia conditions. We, therefore, studied the relationship between walking speed, cognition, and cerebrospinal fluid biomarkers in persons with subjective (SCI) and mild cognitive impairment (MCI). METHODS: We conducted a cross-sectional study of 22 healthy controls, 30 SCI and 17 MCI (N = 69). Walking speed was measured by a 10-m gait test at usual and fast pace...
January 2, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29289973/neurological-and-neuropsychological-complications-in-the-course-of-chronic-whipple-s-disease-case-report
#9
Izabela Dymon, Justyna Tabaka-Pradela, Katarzyna Anna Knast, Dominika Dudek, Monika Rudzińska
INTRODUCTION: Whipple's disease (WD) is a chronic, multisystemic infectious disease caused by Gram-positive bacillus Tropheryma whipplei (T.w.). Its common symptoms arise in the digestive system, however, during the infection the CNS (Central Nervous System) may also be affected. AIM: The aim of this work is to present a case report of a patient diagnosed with Whipple's disease with dominant neuropsychological and behavioural complications in the late phase. CONCLUSIONS: Whipple's disease is a rare disease with possible neurological and neuropsychiatric complications...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29235432/impact-of-informal-caregiving-on-cognitive-function-and-well-being-in-canada
#10
Sasha Mallya, Alexandra J Fiocco
BACKGROUND: With a rise in the aging population and a consequential rise in persons diagnosed with dementia comes an increase in the number of informal caregivers who are caring for a loved one. The objective of the proposed study was to assess the neurocognitive and psychological effects of caring for a person with dementia or a related neurodegenerative disease in a sample of Canadian informal caregivers. METHODS: Fifty-seven informal caregivers of a person with dementia or a related neurodegenerative disease (mean age = 66...
December 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223069/neuropsychological-and-clinical-heterogeneity-of-cognitive-impairment-in-patients-with-multiple-system-atrophy
#11
Lorena Broseghini Barcelos, Flávia Saad, Carla Giacominelli, Roberta Arb Saba, Patrícia Maria de Carvalho Aguiar, Sonia Maria Azevedo Silva, Vanderci Borges, Paulo Henrique Ferreira Bertolucci, Henrique Ballalai Ferraz
OBJECTIVE: We evaluated neuropsychological tests to compare cognitive impairment between two types of multiple system atrophy: predominant parkinsonism (MSA-P) and predominant cerebellar ataxia (MSA-C). PATIENTS AND METHODS: This cross-sectional study included 14 patients diagnosed with MSA: four with MSA-C and ten with MSA-P. Presence of motor symptoms was determined by using the Unified Rating MSA Scale (URMSAS). Non-motor symptoms were evaluated by the Short Form Health Survey (SF-36), Scales for Outcomes in Parkinson's disease Autonomic (SCOPA-AUT), Hospital Anxiety and Depression Scale (HADS), and Beck Depression Inventory (BDI)...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29202529/-characteristics-of-cognitive-function-behavioral-and-psychological-symptoms-in-patients-with-alzheimer-s-disease-versus-behavioral-variant-frontotemporal-dementia
#12
L L Zhang, Y Wang, Y Cheng, N Zhang
Objective: To compare the differences in cognitive function and behavioral and psychological symptoms between patients with Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD). Methods: Thirty-six AD patients and 20 bvFTD patients at mild-to-moderate stage, who were biomarker-confirmed by positron emission tomography (PET), were assessed with a neuropsychological battery and neuropsychiatry inventory (NPI). Cognitive domains, including memory, language, information processing speed and executive function, and behavioral and psychological symptoms were assessed and compared...
December 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29182360/relationship-between-smell-identification-testing-and-the-neuropsychological-assessment-of-dementia-in-community-dwelling-adults
#13
William Goette, Andrew Schmitt, Avery Clark
The objective of this research was to investigate the relationship of the University of Pennsylvania Smell Identification Test (UPSIT) with neuropsychological tests and identify the utility of the UPSIT in detecting cognitive impairment. This research was an archival study of neuropsychological test results obtained from 70 clients (30 male/40 female) of a community-based memory clinic. The sample had an average age of 69.7 (SD = 9.7) and education of 14.6 (SD = 2.8) years. Hypotheses were tested using correlations, receiver operating characteristic (ROC) curves, and logistic regression...
November 28, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29171995/high-caregiver-burden-in-young-onset-dementia-what-factors-need-attention
#14
Linda Lim, Angeline Zhang, Levinia Lim, Tanya-Marie Choong, Eveline Silva, Adeline Ng, Nagaendran Kandiah
BACKGROUND: There is an increase in prevalence of young onset dementia (YOD). The specific problems among YOD patients and levels of caregiver burden (CB) in this group warrants further evaluation. OBJECTIVE: To evaluate and compare level of CB in YOD and late onset dementia (LOD). Also, we sought to understand the specific factors, such as neuropsychiatric symptoms, that may affect the levels of caregiver burden in the YOD group. METHODS: Patient-caregiver dyads with YOD and LOD were recruited from a tertiary neurology center...
November 20, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29165083/subjective-spatial-navigation-complaints-a-frequent-symptom-reported-by-patients-with-subjective-cognitive-decline-mild-cognitive-impairment-and-alzheimer-s-disease
#15
Jiri Cerman, Ross Andel, Jan Laczo, Martin Vyhnalek, Zuzana Nedelska, Ivana Mokrisova, Katerina Sheardova, Jakub Hort
BACKGROUND: Great effort has been put into developing simple and feasible tools capable to detect Alzheimer's disease (AD) in its early clinical stage. Spatial navigation impairment occurs very early in AD and is detectable even in the stage of mild cognitive impairment (MCI). OBJECTIVE: The aim was to describe the frequency of self-reported spatial navigation complaints in patients with subjective cognitive decline (SCD), amnestic and non-amnestic MCI (aMCI, naMCI) and AD dementia and to assess whether a simple questionnaire based on these complaints may be used to detect early AD...
November 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29123489/plasmapheresis-responsive-rapid-onset-dementia-with-predominantly-frontal-dysfunction-in-the-context-of-hashimoto-s-encephalopathy
#16
Dominique Endres, Magnus S Vry, Petra Dykierek, Anne N Riering, Eva Lüngen, Oliver Stich, Rick Dersch, Nils Venhoff, Daniel Erny, Irina Mader, Philipp T Meyer, Ludger Tebartz van Elst
Background: Hashimoto's encephalopathy (HE) is a rare immunological neuropsychiatric disorder characterized by increased antithyroid antibodies and mixed neurological and psychiatric symptoms. HE has been previously discussed as a differential diagnosis for rapid progressive dementia. However, most of these patients suffered from additional neurological symptoms, like ataxia or seizures. Case presentation: Here, we present the case of a 59-year-old female patient suffering rapid onset dementia with salient frontal executive dysfunction...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29120563/diagnosing-and-managing-mild-cognitive-impairment
#17
Sophie Behrman, Vyara Valkanova, Charlotte L Allan
There has been a rapid rise in the number of people diagnosed with dementia in England from 232,000 in 2008 to 850,000 in 2014. Currently, it is estimated that the prevalence of mild cognitive impairment in adults aged 65 and over is 10-20%. It is likely that this figure will increase in line with trends in dementia diagnosis. In some cases, mild cognitive impairment may be a prodrome for dementia, and my be caused by any of the dementia pathology subtypes. The relationship between depression in the elderly and mild cognitive impairment is difficult to tease out as they are frequently comorbid conditions and both have been found to be independent risk factors for subsequent dementia: about 10% convert to dementia each year, compared with 1-2% of the general elderly population...
May 2017: Practitioner
https://www.readbyqxmd.com/read/29107184/anxiety-like-behavior-as-an-early-endophenotype-in-the-tgf344-ad-rat-model-of-alzheimer-s-disease
#18
Nathan S Pentkowski, Laura E Berkowitz, Shannon M Thompson, Emma N Drake, Carlos R Olguin, Benjamin J Clark
Alzheimer's disease (AD) is characterized by progressive cognitive decline and the presence of aggregates of amyloid beta (plaques) and hyperphosphorylated tau (tangles). Early diagnosis through neuropsychological testing is difficult due to comorbidity of symptoms between AD and other types of dementia. As a result, there is a need to identify the range of behavioral phenotypes expressed in AD. In the present study, we utilized a transgenic rat (TgF344-AD) model that bears the mutated amyloid precursor protein as well as presenilin-1 genes, resulting in progressive plaque and tangle pathogenesis throughout the cortex...
October 5, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29099546/the-diagnostic-challenge-of-the-late-onset-frontal-lobe-syndrome-clinical-predictors-for-primary-psychiatric-disorders-versus-behavioral-variant-frontotemporal-dementia
#19
Everard G B Vijverberg, Flora Gossink, Welmoed Krudop, Sietske Sikkes, Cora Kerssens, Niels Prins, Max Stek, Philip Scheltens, Yolande Pijnenburg, Annemiek Dols
OBJECTIVE: Primary psychiatric disorders (PsD) can present with symptomatology identical to that of behavioral variant frontotemporal dementia (bvFTD). To date, clinical guidelines do not provide a solution for this diagnostic challenge. The aim of our study was to prospectively determine which demographic, clinical, neuropsychological, neuroimaging, and cerebrospinal fluid biomarkers are important in distinguishing PsD from bvFTD. METHODS: Patients with late-onset behavioral disturbances (aged 45-75 years, 73% male) were included based on their scores on the Frontal Behavioral Inventory and the Stereotypy Rating Inventory and followed for 2 years from April 2011 to June 2015...
November 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29096387/clinical-and-neuropsychological-profile-of-persons-with-mild-cognitive-impairment-a-hospital-based-study-from-a-lower-and-middle-income-country
#20
Srikala Bharath, Shilpa Sadanand, Keshav J Kumar, Rakesh Balachandar, Himanshu Joshi, Mathew Varghese
Mild Cognitive impairment (MCI) is an important pre-dementia stage to be identified towards prevention. We screened a large number of older adults seeking help at hospital and community towards a diagnosis of MCI and this study describe their clinical and neuropsychological profile. Older adults aged 60 years & above seeking help at NIMHANS outpatient & community services were screened for early cognitive deficits. Persons were diagnosed to have MCI according to Petersen's criteria, after detailed clinical and neuropsychological assessments...
October 16, 2017: Asian Journal of Psychiatry
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