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https://www.readbyqxmd.com/read/29777172/contrasting-patterns-of-runx2-repeat-variations-are-associated-with-palate-shape-in-phyllostomid-bats-and-new-world-primates
#1
Tiago Ferraz, Daniela M Rossoni, Sérgio L Althoff, Alcides Pissinatti, Vanessa R Paixão-Cortês, Maria Cátira Bortolini, Rolando González-José, Gabriel Marroig, Francisco M Salzano, Gislene L Gonçalves, Tábita Hünemeier
Establishing the genetic basis that underlies craniofacial variability in natural populations is one of the main topics of evolutionary and developmental studies. One of the genes associated with mammal craniofacial variability is RUNX2, and in the present study we investigated the association between craniofacial length and width and RUNX2 across New World bats (Phyllostomidae) and primates (Catarrhini and Platyrrhini). Our results showed contrasting patterns of association between the glutamate/alanine ratios (Q/A ratio) and palate shape in these highly diverse groups...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29750100/orofacial-clinical-features-in-arnold-chiari-type-i-malformation-a-case-series
#2
José-Alcides de Arruda, Eugênia Figueiredo, João-Luiz Monteiro, Livia-Mirelle Barbosa, Cleomar Rodrigues, Belmiro Vasconcelos
Background: Arnold Chiari malformation (ACM) is characterized by an anatomical defect at the base of the skull where the cerebellum and the spinal cord herniate through the foramen magnum into the cervical spinal canal. Among the subtypes of the condition, ACM type I (ACM-I) is particularly outstanding because of the severity of symptoms. This study aimed to analyze the orofacial clinical manifestations of patients with ACM-I, and discuss their demographic distribution and clinical features in light of the literature...
April 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29750098/effect-of-surface-treatments-with-acid-solutions-on-the-surface-roughness-of-an-yttrium-tetragonal-zirconia-polycrystal
#3
Frederico Goyatá, Yvna Galvão, Thamyryz-Rafaela Simões, Luiz-Felipe Goyatá, José-Alcides Arruda, Amália Moreno
Background: The purpose of this in vitro study was to evaluate the effect of conventional surface treatment with acid solutions on the surface roughness of a zirconia-based ceramic. Material and Methods: Specimens of yttrium-tetragonal zirconia polycrystal (Y-TZP) -based ceramic were fabricated (5.0 x 5.0 x 2.0 mm, n=40). The specimens were submitted to the tested surface treatment method and divided into 4 groups (n=10): no treatment-control (GI), airborne 110 µm aluminum oxide particle abrasion for 1 minute-conventional method (GII); etching with 48% hydrofluoric acid for 2 minutes (GIII), and nitric acid/hydrofluoric acid etching for 2 minutes (GIV)...
April 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29747049/thromboembolic-findings-in-patients-with-heart-failure-at-autopsy
#4
Isabella Sales de Macedo, Layara Fernanda Lipari Dinardi, Thiago Vicente Pereira, Lyna Kyria Rodrigues de Almeida, Thaisa Silveira Barbosa, Luiz Alberto Benvenuti, Silvia Moreira Ayub-Ferreira, Edimar Alcides Bocchi, Victor Sarli Issa
BACKGROUND: The risk of thromboembolic events is increased in patients with heart failure (HF); however, few studies have reported thromboembolic findings in HF patients who have undergone autopsy. METHODS AND RESULTS: We reviewed 1457 autopsies (January 2000/July 2006) and selected 595 patients with HF. We studied the occurrence of thromboembolic events in patients' autopsy reports. Mean age was 61.8±15.9 years; 376 (63.2%) were men and 219 (36.8%) women; left ventricular ejection fraction was 42...
April 13, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29738629/calcifying-odontogenic-cyst-dentinogenic-ghost-cell-tumor-and-ghost-cell-odontogenic-carcinoma-a-systematic-review
#5
REVIEW
José Alcides Almeida de Arruda, João Luiz Gomes Carneiro Monteiro, Lucas Guimarães Abreu, Leni Verônica de Oliveira Silva, Lauren Frenzel Schuch, Mariana Saturnino de Noronha, Gerhilde Callou, Amália Moreno, Ricardo Alves Mesquita
BACKGROUND: The aim of this study was to integrate the available data published on calcifying odontogenic cyst (COC), dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinomas (GCOC) into a comprehensive analysis of their clinicoradiological features, treatment and recurrence. MATERIALS AND METHODS: An electronic search with no publication date restriction was undertaken in October 2017 in the following databases: PubMed, Medline Ovid, Web of Science and Scopus...
May 8, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29723595/cost-effectiveness-benefits-of-a-disease-management-program-the-remadhe-trial-results
#6
Edimar Alcides Bocchi, Fátima das Dores da Cruz, Sara MIchelly Brandão, Victor Issa, Silvia Moreira Ayub-Ferreira, Hans-Peter Brunner-La Rocca, Sandra Sanders-van Wijk
BACKGROUND: Published studies have generated mixed, controversial results regarding the cost-effectiveness of heart failure-disease management programs (HF-DMP). This study assessed the cost-effectiveness of an HF-DMP in ambulatory patients compared with usual care (UC). METHODS: In the prospective, randomized REMADHE trial, we evaluated incremental costs per quality-adjusted life-year (QALY) and life-year (LY) gained as effectiveness ratios (ICERs) over a study period of 2...
April 30, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29702041/influence-of-the-c677t-polymorphism-of-the-mthfr-gene-on-oxidative-stress-in-women-with-overweight-or-obesity-response-to-a-dietary-folate-intervention
#7
Marina Ramalho Ribeiro, Raquel Patrícia Ataíde Lima, Jéssica Vanessa de Carvalho Lisboa, Thamires Ribeiro Chaves, Rafaella Cristhine Pordeus Luna, Rayner Anderson Ferreira do Nascimento, Yohanna de Oliveira, Darlene Camati Persuhn, Alexandre Sérgio da Silva, Maria da Conceição Rodrigues Gonçalves, Flávia Emília Leite de Lima Ferreira, Roberto Teixeira Lima, Alcides da Silva Diniz, Alessio Tony Cavalcanti de Almeida, Ronei Marcos de Moraes, Eliseu Verly Junior, Maria José de Carvalho Costa
The C677T polymorphism of the methylenetetrahydrofolate reductase gene (MTHFR) is related to folate metabolism and can alter the levels of biochemical markers. OBJECTIVE: Investigate the influence of the MTHFR C677T polymorphism on the effects of a dietary folate intervention on oxidative stress in women with overweight or obesity. METHODS: Forty-eight adult women with overweight or obesity were subjected to a 24-hour dietary recall, anthropometric measurements, biochemical analysis, and genotyping of the MTHFR C677T polymorphism...
April 27, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29650540/next-generation-sequencing-of-the-complete-mitochondrial-genome-of-the-endangered-species-black-lion-tamarin-leontopithecus-chrysopygus-primates-and-mitogenomic-phylogeny-focusing-on-the-callitrichidae-family
#8
Patrícia Domingues de Freitas, Fernando Luis Mendez, Karla Chávez-Congrains, Pedro Manoel Galetti, Luiz Lehmann Coutinho, Alcides Pissinatti, Carlos Daniel Bustamante
We describe the complete mitochondrial genome sequence of the Black Lion Tamarin, an endangered primate species endemic to the Atlantic Rainforest of Brazil. We assembled the Leontopithecus chrysopygus mitogenome, through analysis of 523M base pairs (bp) of short reads produced by next-generation sequencing (NGS) on the Illumina Platform, and investigated the presence of nuclear mitochondrial pseudogenes and heteroplasmic sites. Additionally, we conducted phylogenetic analyses using all complete mitogenomes available for primates until June 2017...
April 12, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29561950/a-multicenter-study-of-biopsied-oral-and-maxillofacial-lesions-in-a-brazilian-pediatric-population
#9
Leni Verônica de Oliveira Silva, José Alcides Almeida Arruda, Stephanie Joana Martelli, Camila de Nazaré Alves de Oliveira Kato, Laiz Fernanda Mendes Nunes, Ana Carolina Uchoa Vasconcelos, Sandra Beatriz Chaves Tarquinio, Ana Paula Neutzling Gomes, Ricardo Santiago Gomez, Ricardo Alves Mesquita, Marcia Maria Fonseca da Silveira, Ana Paula Veras Sobral
The aim of this study was to investigate the prevalence of oral and maxillofacial lesions among children from representative regions of Brazil. A retrospective descriptive study was conducted. Biopsy records comprising the period from 2000 to 2015 were obtained from the archives of three Brazilian oral pathology referral centers. A total of 32,506 biopsy specimens were analyzed, and specimens from 1,706 children aged 0-12 years were selected. Gender, age, anatomical location and histopathological diagnosis were evaluated...
March 15, 2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/29551518/embolization-as-the-primary-treatment-for-mandibular-arteriovenous-malformations-an-analysis-of-50-literature-reports-and-of-an-illustrative-case
#10
REVIEW
João Luiz Gomes Carneiro Monteiro, José Alcides Almeida de Arruda, Jefferson Luiz Figueiredo Leal, Laécio Leitão Batista, Suzana Célia de Aguiar Soares Carneiro, Belmiro Cavalcante do Egito Vasconcelos
PURPOSE: The aim of the present report is to describe 50 cases in the literature of mandibular arteriovenous malformations (AVMs) in which embolization was the primary treatment and to discuss details such as age, gender, materials used, outcome of embolization, time of follow-up, and intra- or postprocedure complications. An illustrative case in which reossification was noticed after embolization also is presented. PATIENTS AND METHODS: The study was carried out in 2 steps...
February 22, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29540327/carvedilol-for-prevention-of-chemotherapy-related-cardiotoxicity
#11
Monica Samuel Avila, Silvia Moreira Ayub-Ferreira, Mauro Rogerio de Barros Wanderley Junior, Fatima das Dores Cruz, Sara Michelly Gonçalves Brandão, Vagner Oliveira Carvalho Rigaud, Marilia Higushi-Dos-Santos, Ludhmila Abrahão Hajjar, Roberto Kalil Filho, Paulo Marcelo Hoff, Marina Sahade, Marcela S M Ferrari, Romulo Leopoldo de Paula Costa, Max Senna Mano, Cecilia Beatriz Bittencourt Viana Cruz, Maria Cristina Abduch, Marco Stephan Lofrano Alves, Guilherme Veiga Guimaraes, Victor Sarli Issa, Marcio Sommer Bittencourt, Edimar Alcides Bocchi
BACKGROUND: Anthracycline (ANT) chemotherapy is associated with cardiotoxicity. Prevention with β-blockers remains controversial. OBJECTIVE: The aim of this prospective, randomized, double-blind, placebo-controlled study was to evaluate the role of carvedilol in preventing ANT cardiotoxicity. METHODS: We randomized 200 patients with HER2-negative breast cancer tumor status and normal left ventricular ejection fraction (LVEF) referred for ANT (240 mg/m2 ) to receive carvedilol or placebo until chemotherapy completion...
March 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29505826/phylogeny-molecular-dating-and-zoogeographic-history-of-the-titi-monkeys-callicebus-pitheciidae-of-eastern-brazil
#12
Jeferson Carneiro, Iracilda Sampaio, José de Sousa E Silva-Júnior, Izeni Farias, Tomas Hrbek, Alcides Pissinatti, Ronylson Silva, Antônio Martins-Junior, Jean Boubli, Stephen Francis Ferrari, Horacio Schneider
The titi monkeys belong to a genus of New World primates endemic to South America, which were recently reclassified in three genera (Cheracebus, Plecturocebus and Callicebus). The genus Callicebus, which currently includes five species, is endemic to eastern Brazil, occurring in the Caatinga, Savanna, and Atlantic Forest biomes. In the present study, we investigated the validity of these species and inferred their phylogenetic relationships, divergence times, and biogeographic patterns based on the molecular analysis of a concatenated sequence of 11 mitochondrial and nuclear DNA markers, derived from 13 specimens...
July 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29459798/-localization-and-size-of-colon-adenomas-as-factors-related-to-high-gradedysplasia
#13
Carlo Arévalo, Natalia Chunga, Steven Alarcón, Omar Rodríguez, Fernando Arévalo, Pedro Montes, Eduardo Monge
OBJECTIVE: To determine whether localization and size are related to the presence of high-grade dysplasia of colon adenomas in patients of a Peruvian hospital. MATERIALS AND METHODS: This is a descriptive transversal study. We checked colonoscopyreports of 2014-2015 years of Hospital Daniel Alcides Carrion, we included the polyps found in patients older than 18 years old, and excluded reports from patients with colorectal cancer, an antecedent of oncological surgery, inflammatory bowel disease and polyposis (6 or more)...
October 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29432453/clinical-findings-and-prognosis-of-patients-hospitalized-for-acute-decompensated-heart-failure-analysis-of-the-influence-of-chagas-etiology-and-ventricular-function
#14
Caíque Bueno Terhoch, Henry Fukuda Moreira, Silvia Moreira Ayub-Ferreira, Germano Emilio Conceição-Souza, Vera Maria Cury Salemi, Paulo Roberto Chizzola, Mucio Tavares Oliveira, Silvia Helena Gelas Lage, Edimar Alcides Bocchi, Victor Sarli Issa
AIMS: Explore the association between clinical findings and prognosis in patients with acute decompensated heart failure (ADHF) and analyze the influence of etiology on clinical presentation and prognosis. METHODS AND RESULTS: Prospective cohort of 500 patients admitted with ADHF from Aug/2013-Feb/2016; patients were predominantly male (61.8%), median age was 58 (IQ25-75% 47-66 years); etiology was dilated cardiomyopathy in 141 (28.2%), ischemic heart disease in 137 (27...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29391199/leishmanicidal-and-cytotoxic-activity-from-plants-used-in-tacana-traditional-medicine-bolivia
#15
Diandra Arévalo-Lopéz, Nélida Nina, Juan C Ticona, Ivan Limachi, Efrain Salamanca, Enrique Udaeta, Crispin Paredes, Boris Espinoza, Alcides Serato, David Garnica, Abigail Limachi, Dayana Coaquira, Sarah Salazar, Ninoska Flores, Olov Sterner, Alberto Giménez
ETNOPHARMACOLOGICAL RELEVANCE: Thirty-eight Tacana medicinal plant species used to treat skin problems, including leishmania ulcers, skin infections, inflammation and wound healing, were collected in the community of Buena Vista, Bolivia, with the Tacana people. Twenty two species are documented for the first time as medicinal plants for this ethnic group living in the northern area of the Department of La Paz. AIM OF THE STUDY: To evaluate the leishmanicidal effect (IC50 ) and cytotoxicity (LD50 ) of the selected plants...
April 24, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29390308/utility-and-quality-adjusted-life-years-in-coronary-artery-disease-five-year-follow-up-of-the-mass-ii-trial
#16
RANDOMIZED CONTROLLED TRIAL
Sara Michelly Gonçalves Brandão, Whady Hueb, Yang Ting Ju, Antonio Carlos Pedroso de Lima, Carisi Anne Polanczyk, Luciane Nascimento Cruz, Rosa Maria Rahmi Garcia, Myrthes Emy Takiuti, Edimar Alcides Bocchi
OBJECTIVES: This study evaluated the utility and quality-of-life year measurements for patients with coronary artery disease who underwent any of 3 therapeutic strategies with a 5-year follow-up. METHODS: Quality-of-life data were obtained from the Medicine, Angioplasty, or Surgery Study II trial. To obtain utilities, the 36-Item Short-Form questionnaire was converted to a 6-Dimensional Health State Classification System. RESULTS: Of the 611 initial patients, 579 completed the questionnaire...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29311638/an-assay-for-the-identification-of-plasmodium-simium-infection-for-diagnosis-of-zoonotic-malaria-in-the-brazilian-atlantic-forest
#17
Denise Anete Madureira de Alvarenga, Richard Culleton, Anielle de Pina-Costa, Danielle Fonseca Rodrigues, Cesare Bianco, Sidnei Silva, Ana Júlia Dutra Nunes, Julio César de Souza, Zelinda Maria Braga Hirano, Sílvia Bahadian Moreira, Alcides Pissinatti, Filipe Vieira Santos de Abreu, André Luiz Lisboa Areas, Ricardo Lourenço-de-Oliveira, Mariano Gustavo Zalis, Maria de Fátima Ferreira-da-Cruz, Patricia Brasil, Cláudio Tadeu Daniel-Ribeiro, Cristiana Ferreira Alves de Brito
Zoonotic malaria poses a unique problem for malaria control. Autochthonous cases of human malaria in the Atlantic Forest have recently been attributed to Plasmodium simium, a parasite that commonly infects non-human primates in this Brazilian biome. However, due to its close similarity at both the morphological and molecular level to Plasmodium vivax, the diagnosis of P. simium in this region remains problematic. Therefore, a diagnostic assay able to accurately identify P. simium is important for malaria surveillance...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29258776/waste-disposal-and-households-heterogeneity-identifying-factors-shaping-attitudes-towards-source-separated-recycling-in-bogot%C3%A3-colombia
#18
Alcides J Padilla, Juan C Trujillo
Solid waste management in many cities of developing countries is not environmentally sustainable. People traditionally dispose of their solid waste in unsuitable urban areas like sidewalks and satellite dumpsites. This situation nowadays has become a serious public health problem in big Latin American conurbations. Among these densely-populated urban spaces, the Colombia's capital and main city stands out as a special case. In this study, we aim to identify the factors that shape the attitudes towards source-separated recycling among households in Bogotá...
April 2018: Waste Management
https://www.readbyqxmd.com/read/29236726/demographic-monitoring-of-wild-muriqui-populations-criteria-for-defining-priority-areas-and-monitoring-intensity
#19
Karen B Strier, Carla B Possamai, Fernanda P Tabacow, Alcides Pissinatti, Andre M Lanna, Fabiano Rodrigues de Melo, Leandro Moreira, Maurício Talebi, Paula Breves, Sérgio L Mendes, Leandro Jerusalinsky
Demographic data are essential to assessments of the status of endangered species. However, establishing an integrated monitoring program to obtain useful data on contemporary and future population trends requires both the identification of priority areas and populations and realistic evaluations of the kinds of data that can be obtained under different monitoring regimes. We analyzed all known populations of a critically endangered primate, the muriqui (genus: Brachyteles) using population size, genetic uniqueness, geographic importance (including potential importance in corridor programs) and implementability scores to define monitoring priorities...
2017: PloS One
https://www.readbyqxmd.com/read/29224821/a-multicenter-study-of-malignant-oral-and-maxillofacial-lesions-in-children-and-adolescents
#20
José Alcides Almeida de Arruda, Leni Verônica de Oliveira Silva, Camila de Nazaré Alves de Oliveira Kato, Lauren Frenzel Schuch, Aline Carvalho Batista, Nádia Lago Costa, Sandra Beatriz Chaves Tarquinio, Elena Riet Correa Rivero, Vinícius Coelho Carrard, Manoela Domingues Martins, Ana Paula Veras Sobral, Ricardo Alves Mesquita
OBJECTIVES: To investigate the frequency of malignant oral and maxillofacial lesions among children and adolescents from representative geographic regions of Brazil. MATERIALS AND METHODS: A retrospective study was conducted on biopsies obtained from 1990 to 2016 at six Brazilian oral and maxillofacial pathology referral centers. A total of 85,105 biopsy specimens from children and adolescents were analyzed. Gender, age, anatomical location, symptomatology and histopathological diagnosis were evaluated...
December 2017: Oral Oncology
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