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https://www.readbyqxmd.com/read/28911515/chronic-chagas-heart-disease%C3%A2-management-from-etiology-to-cardiomyopathy-treatment
#1
REVIEW
Edimar Alcides Bocchi, Reinaldo Bulgarelli Bestetti, Mauricio Ibrahim Scanavacca, Edecio Cunha Neto, Victor Sarli Issa
Trypanosoma cruzi (T. cruzi) infection is endemic in Latin America and is becoming a worldwide health burden. It may lead to heterogeneous phenotypes. Early diagnosis of T. cruzi infection is crucial. Several biomarkers have been reported in Chagas heart disease (ChHD), but most are nonspecific for T. cruzi infection. Prognosis of ChHD patients is worse compared with other etiologies, with sudden cardiac death as an important mode of death. Most ChHD patients display diffuse myocarditis with fibrosis and hypertrophy...
September 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28902943/use-of-fibrinogen-and-thrombin-sponge-in-pediatric-split-liver-transplantation
#2
Fernando Pompeu Piza Vicentine, Adriano Miziara Gonzalez, Barbara Burza Beninni, Ramiro Anthero de Azevedo, Marcelo Moura Linhares, Alberto Goldenberg, Gaspar de Jesus Lopes, Jose Luiz Martins, Alcides Augusto Salzedas
Purpose: To analyze the use of this sponge in pediatric patients undergoing split-liver transplantation. Methods: Retrospective study, including 35 pediatric patients undergoing split-liver transplantation, divided into two groups according to the use of the sponge: 18 patients in Group A (no sponge) and 17 in Group B (with sponge). Results: The characteristics of recipients and donors were similar. We observed greater number of reoperation due to bleeding in the wound area in Group A (10 patients - 55...
August 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28890879/streptococcal-pharyngitis-in-children-with-painful-throat-missed-opportunities-for-rheumatic-heart-disease-prevention-in-endemic-area-of-africa
#3
EDITORIAL
Geoffrey Madeira, Daniel Chicavel, Alcides Munguambe, José Langa, Ana Mocumbi
No abstract text is available yet for this article.
August 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28876411/binge-drinking-and-illicit-drug-use-among-adolescent-students
#4
Jakelline Cipriano Dos Santos Raposo, Ana Carolina de Queiroz Costa, Paula Andréa de Melo Valença, Patrícia Maria Zarzar, Alcides da Silva Diniz, Viviane Colares, Carolina da Franca
OBJECTIVE: To estimate the prevalence of illicit drug use and its association with binge drinking and sociodemographic factors among adolescent students. METHODS: This is a cross-sectional study with probabilistic conglomerate sampling, involving 1,154 students, aged 13 to 19 years old, from the public school system, in the city of Olinda, State of Pernambuco, Brazil, carried out in 2014. We used the Youth Risk Behavior Survey questionnaire, validated for use with Brazilian adolescents...
September 4, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28867401/outbreak-of-human-malaria-caused-by-plasmodium-simium-in-the-atlantic-forest-in-rio-de-janeiro-a-molecular-epidemiological-investigation
#5
Patrícia Brasil, Mariano Gustavo Zalis, Anielle de Pina-Costa, Andre Machado Siqueira, Cesare Bianco Júnior, Sidnei Silva, André Luiz Lisboa Areas, Marcelo Pelajo-Machado, Denise Anete Madureira de Alvarenga, Ana Carolina Faria da Silva Santelli, Hermano Gomes Albuquerque, Pedro Cravo, Filipe Vieira Santos de Abreu, Cassio Leonel Peterka, Graziela Maria Zanini, Martha Cecilia Suárez Mutis, Alcides Pissinatti, Ricardo Lourenço-de-Oliveira, Cristiana Ferreira Alves de Brito, Maria de Fátima Ferreira-da-Cruz, Richard Culleton, Cláudio Tadeu Daniel-Ribeiro
BACKGROUND: Malaria was eliminated from southern and southeastern Brazil over 50 years ago. However, an increasing number of autochthonous episodes attributed to Plasmodium vivax have recently been reported from the Atlantic Forest region of Rio de Janeiro state. As the P vivax-like non-human primate malaria parasite species Plasmodium simium is locally enzootic, we performed a molecular epidemiological investigation to determine whether zoonotic malaria transmission is occurring. METHODS: We examined blood samples from patients presenting with signs or symptoms suggestive of malaria as well as from local howler monkeys by microscopy and PCR...
August 31, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28863180/a-non-invasive-specimen-collection-method-and-a-novel-simian-foamy-virus-sfv-dna-quantification-assay-in-new-world-primates-reveal-aspects-of-tissue-tropism-and-improved-sfv-detection
#6
Cláudia P Muniz, HaoQiang Zheng, Hongwei Jia, Liliane T F Cavalcante, Anderson M Augusto, Luiz P Fedullo, Alcides Pissinatti, Marcelo A Soares, William M Switzer, André F Santos
Simian foamy viruses (SFVs) co-evolved with a wide range of Old World and New World primates (OWPs and NWPs, respectively) and occasionally transmit to humans. Previous studies of OWPs showed that the predominant site of SFV replication is the oral mucosa. However, very little is known about SFV viral loads (VLs) in the oral mucosa or blood of NWPs. NWPs have smaller body sizes, limiting collection of sufficient whole blood volumes to molecularly detect and quantify SFV. Our study evaluated the use of noninvasively collected buccal swabs to detect NWP SFV compared with detection in blood using a new NWP SFV quantitative PCR (qPCR) assay...
2017: PloS One
https://www.readbyqxmd.com/read/28836008/alpha2-adrenoceptors-in-adrenomedullary-chromaffin-cells-functional-role-and-pathophysiological-implications
#7
REVIEW
Antonio R Artalejo, Luis Alcides Olivos-Oré
Chromaffin cells from the adrenal medulla participate in stress responses by releasing catecholamines into the bloodstream. Main control of adrenal catecholamine secretion is exerted both neurally (by the splanchnic nerve fibers) and humorally (by corticosteroids, circulating noradrenaline, etc.). It should be noted, however, that secretory products themselves (catecholamines, ATP, opioids, ascorbic acid, chromogranins) could also influence the secretory response in an autocrine/paracrine manner. This form of control is activity-dependent and can be either inhibitory or excitatory...
August 23, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28828163/erythema-multiforme-induced-by-alendronate-sodium-in-a-geriatric-patient-a-case-report-and-review-of-the-literature
#8
José-Alcides de Arruda, Pedro Silva, Márcio-Bruno Amaral, Fernanda Cotta, Renata Avendanho, Ricardo Mesquita
Erythema multiforme is an uncommon acute inflammatory disorder caused by exposure to microbes or drugs. Erythema multiforme minor typically affects only one mucosa and can be associated with symmetrical target skin lesions on the extremities. The disease usually occurs in patients in their 3rd and 4th decade of life, but can also affect children and adolescents. Alendronate sodium has been approved for the prevention and treatment of osteoporosis in postmenopausal women, but is associated with adverse events...
July 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28822697/head-and-neck-myiasis-a-case-series-and-review-of-the-literature
#9
José Alcides Almeida de Arruda, Leni Verônica de Oliveira Silva, Pedro Urquiza Jayme Silva, Eugênia Leal de Figueiredo, Gerhilde Callou, Ricardo Alves Mesquita, Belmiro Cavalcanti do Egito Vasconcelos
OBJECTIVE: This study describes 9 cases of myiasis affecting the head and neck region and discusses the demographic distribution, treatment, clinical characteristics, and sequelae of the disease in light of the literature. STUDY DESIGN: The study was performed in 2 steps. In the first part, 9 cases seen over a period of 10 years at the Emergency Department of Hospital da Restauração in Brazil were studied. In the second part, a literature search was performed in PubMed for articles on head and neck myiasis published from 1975 to March 2017...
July 5, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28792296/developmental-benefits-of-extracurricular-sports-participation-among-brazilian-youth
#10
Riller S Reverdito, Larissa R Galatti, Humberto M Carvalho, Alcides J Scaglia, Jean Côté, Carlos E Gonçalves, Roberto R Paes
Youth sporting activities have been explored as a way to impact positive personal transformation and development, glaringly demonstrated by world-wide investments in public policies, programs, and projects. We studied positive effects of participation in sports on the developmental assets of 614 adolescents (13.1 ± 1.7 years) actively engaged in extracurricular sport programs targeted at socially disadvantaged youths, from five municipalities across five states of the southern, south-eastern and north-eastern regions of Brazil...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28761256/root-canal-treatment-of-a-fused-mandibular-incisor-using-cone-beam-computed-tomography-as-a-diagnostic-aid
#11
Maura Cristiane Orçati Dorielo, Alcides Gonini-Junior, Durvalino de Oliveira, Renata Tarnoschi Bordignon, Alvaro Henrique Borges
Tooth fusion consists of the union of crowns by the enamel and/or dentin. We describe a case of a patient who presented with a fistula in the apical portion of teeth 32 and 33. Clinically, tooth 32 showed increased crown width in relation to other teeth in the same arch. Radiographic examination evidenced fusion of tooth 32 with a possible supernumerary tooth. Cone-beam computed tomography was used to confirm the radiographic findings and revealed incomplete apex formation of the supernumerary tooth. The fused tooth was subjected to root canal treatment...
January 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/28747635/aim1-is-an-actin-binding-protein-that-suppresses-cell-migration-and-micrometastatic-dissemination
#12
Michael C Haffner, David M Esopi, Alcides Chaux, Meltem Gürel, Susmita Ghosh, Ajay M Vaghasia, Harrison Tsai, Kunhwa Kim, Nicole Castagna, Hong Lam, Jessica Hicks, Nicolas Wyhs, Debika Biswal Shinohara, Paula J Hurley, Brian W Simons, Edward M Schaeffer, Tamara L Lotan, William B Isaacs, George J Netto, Angelo M De Marzo, William G Nelson, Steven S An, Srinivasan Yegnasubramanian
A defining hallmark of primary and metastatic cancers is the migration and invasion of malignant cells. These invasive properties involve altered dynamics of the cytoskeleton and one of its major structural components β-actin. Here we identify AIM1 (absent in melanoma 1) as an actin-binding protein that suppresses pro-invasive properties in benign prostate epithelium. Depletion of AIM1 in prostate epithelial cells increases cytoskeletal remodeling, intracellular traction forces, cell migration and invasion, and anchorage-independent growth...
July 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28742086/predictive-models-for-estimating-visceral-fat-the-contribution-from-anthropometric-parameters
#13
Claudia Porto Sabino Pinho, Alcides da Silva Diniz, Ilma Kruze Grande de Arruda, Ana Paula Dornelas Leão Leite, Marina de Moraes Vasconcelos Petribú, Isa Galvão Rodrigues
BACKGROUND: Excessive adipose visceral tissue (AVT) represents an independent risk factor for cardiometabolic alterations. The search continues for a highly valid marker for estimating visceral adiposity that is a simple and low cost tool able to screen individuals who are highly at risk of being viscerally obese. The aim of this study was to develop a predictive model for estimating AVT volume using anthropometric parameters. OBJECTIVE: Excessive adipose visceral tissue (AVT) represents an independent risk factor for cardiometabolic alterations...
2017: PloS One
https://www.readbyqxmd.com/read/28699972/long-term-results-of-a-cardiology-postgraduate-program
#14
Edimar Alcides Bocchi, Danielle Pazzotti Borges, Vagner Oliveira-Carvalho Rigaud
No abstract text is available yet for this article.
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28688181/surface-detail-reproduction-and-dimensional-accuracy-of-molds-influence-of-disinfectant-solutions-and-elastomeric-impression-materials
#15
Ricardo D Guiraldo, Sandrine B Berger, Ronaldo Mt Siqueira, Victor H Grandi, Murilo B Lopes, Alcides Gonini-Júnior, Rodrigo V Caixeta, Rodrigo V de Carvalho, Mário Ac Sinhoreti
This study compared the surface detail reproduction and dimensional accuracy of molds after disinfection using 2% sodium hypochlorite, 2% chlorhexidine digluconate or 0.2% peracetic acid to those of molds that were not disinfected, for four elastomeric impression materials: polysulfide (Light Bodied Permlastic), polyether (Impregum Soft), polydimethylsiloxane (Oranwash L) andpolyvinylsiloxane (Aquasil Ultra LV). The molds were prepared on a matrix by applying pressure, using a perforated metal tray. The molds were removed following polymerization and either disinfected (by soaking in one of the solutions for 15 minutes) or not disinfected...
April 2017: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/28678970/immunohistochemical-expression-of-tgf-%C3%AE-1-and-mmp-9-in-periapical-lesions
#16
Pâmella Recco Álvares, José Alcides Almeida de Arruda, Leorik Pereira da Silva, George João Ferreira do Nascimento, Maria Fonseca da Silveira, Ana Paula Veras Sobral
The objective of this study was to evaluate the expression of matrix metalloproteinase 9 (MMP-9) and transforming growth factor beta (TGF-β1) in periapical lesion samples correlated with the intensity of the inflammatory infiltrate and thickness of the epithelial lining. Forty-five cases of periapical lesions (23 periapical granulomas and 22 radicular cysts) were subjected to morphological and immunohistochemical analyses using anti-MMP-9 and anti-TGF-β1 antibodies. The data were analyzed using the following tests: non-parametric Mann-Whitney, chi-square, Fisher's exact test and Spearman's correlation test (P<0...
July 3, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28678935/indignation-and-hope
#17
EDITORIAL
Alcides Miranda, Cipriano Maia de Vasconcelos
No abstract text is available yet for this article.
July 3, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28665692/excess-ventilation-in-copd-heart-failure-overlap-implications-for-dyspnea-and-exercise-intolerance
#18
Alcides Rocha, Flavio F Arbex, Priscilla A Sperandio, Aline Souza, Ligia Biazzim, Frederico Mancuso, Danilo C Berton, Bruno Hochhegger, Maria Clara N Alencar, Luiz E Nery, Denis E O'Donnell, J Alberto Neder
BACKGROUND: An increased ventilatory response to exertional metabolic demand (high ventilation (⩒E)-carbon dioxide output (⩒CO2) relationship) is a common finding in patients with coexistent COPD-heart failure. We aimed to determine the mechanisms underlying high ⩒E-⩒CO2 and its impact on operating lung volumes, dyspnea and exercise tolerance in these patients. METHODS: Twenty-two ex-smokers with combined COPD and heart failure with reduced left ventricular ejection fraction (LVEF) undertook, after careful treatment optimization, a progressive cycle exercise test with capillary (c) blood gas collection...
June 30, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28664569/development-and-assessment-of-a-new-cage-like-particle-adjuvant
#19
Daiana Bertona, Nazarena Pujato, Iván Bontempi, Verónica Gonzalez, Gabriel Cabrera, Luis Gugliotta, Daniela Hozbor, Alcides Nicastro, Luis Calvinho, Iván Sergio Marcipar
OBJECTIVES: To obtain and assess stable cage-like particles with low surface charge density, which can be prepared using a standardized, economic and scalable method. METHODS: To form these nanoparticles, the lipid composition and proportion as well the method were modified in relation to cage-like particles previously described elsewhere. Bovine albumin was used to compare ISPA performance with that of other adjuvants in mice and to assess stability. Adjuvant efficacy was analysed using a mouse model of Trypanosoma cruzi infection, which shows protection against an intracellular infection that needs a strong cellular response...
June 30, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28662578/tuning-of-enthalpic-entropic-parameters-of-a-protein-redox-center-through-manipulation-of-the-electronic-partition-function
#20
Damian Alvarez-Paggi, Ulises A Zitare, Jonathan Szuster, Marcos N Morgada, Alcides J Leguto, Alejandro J Vila, Daniel H Murgida
Manipulation of the partition function (Q) of the redox center CuA from cytochrome c oxidase is attained by tuning the accessibility of a low lying alternative electronic ground state and by perturbation of the electrostatic potential through point mutations, loop engineering and pH variation. We report clear correlations of the entropic and enthalpic contributions to redox potentials with Q and with the identity and hydrophobicity of the weak axial ligand, respectively.
July 11, 2017: Journal of the American Chemical Society
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