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https://www.readbyqxmd.com/read/28211229/serum-micrornas-as-predictors-for-liver-fibrosis-staging-in-hepatitis-c-virus-associated-chronic-liver-disease-patients
#1
Olfat G Shaker, Mahmoud A Senousy
Accurate staging of liver fibrosis is important for clinical decision making and personalized management. Liver fibrosis is influenced by patients' genomics, including IFNL3 genotype and microRNA expression. However, incorporating microRNAs into fibrosis prediction algorithms has not been investigated. We examined the potential of 8 selected serum microRNAs; miR-122, miR-126, miR-129, miR-199a, miR-155, miR-203a, miR-221, and miR-223 as non-invasive biomarkers to stage liver fibrosis in HCV-associated chronic liver disease (HCV-CLD)...
February 17, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28209407/life-cycle-assessment-of-facile-microwave-assisted-zinc-oxide-zno-nanostructures
#2
D Papadaki, S Foteinis, G H Mhlongo, S S Nkosi, D E Motaung, S S Ray, T Tsoutsos, G Kiriakidis
The life cycle assessment of several zinc oxide (ZnO) nanostructures, fabricated by a facile microwave technique, is presented. Key synthesis parameters such as annealing temperature, varied from 90°C to 220°C, and microwave power, varied from 110W to 710W, are assessed. The effect of these parameters on both the structural characteristics and the environmental sustainability of the nanostructures is examined. The nanostructures were characterized by means of X-ray diffraction (XRD), focused ion beam scanning electron microscopy (FIB-SEM), ultraviolet-visible spectroscopy (UV-Vis), Photoluminescence (PL) and Brunauer-Emmett-Teller (BET) analysis...
February 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28195363/liver-fibrosis-scores-predict-liver-disease-mortality-in-the-united-states-population
#3
Aynur Unalp-Arida, Constance E Ruhl
BACKGROUND AND RATIONALE: Fatty liver disease is common in the United States and worldwide due to changing lifestyles and can progress to fibrosis and cirrhosis contributing to premature death. We examined whether liver fibrosis scores were associated with increased overall and disease-specific mortality in a U.S. population-based prospective survey with up to 23 years of linked-mortality data. METHODS: Data were analyzed from 14,841 viral hepatitis negative adult participants in the third National Health and Nutrition Examination Survey, 1988-1994...
February 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28195177/prevalence-of-nonalcoholic-steatohepatitis-associated-cirrhosis-in-the-united-states-an-analysis-of-national-health-and-nutrition-examination-survey-data
#4
Mohammad Nasser Kabbany, Praveen Kumar Conjeevaram Selvakumar, Kymberly Watt, Rocio Lopez, Zade Akras, Nizar Zein, William Carey, Naim Alkhouri
OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of manifestations ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), fibrosis and eventually cirrhosis. The prevalence of NAFLD has been shown to be increasing over time; however, the prevalence of NASH cirrhosis and advanced fibrosis over time has not been well studied. Estimate the changes in prevalence of NASH cirrhosis and NAFLD-associated advanced fibrosis among adults in the United States...
February 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28186740/effect-of-low-energy-waves-on-the-accumulation-and-transport-of-fecal-indicator-bacteria-in-sand-and-pore-water-at-freshwater-beaches
#5
Ming Zhi Wu, Denis Michael O'Carroll, Laura Jill Vogel, Clare E Robinson
Elevated fecal indicator bacteria (FIB) in beach sand and pore water represent an important non-point source of contamination to surface waters. This study examines the physical processes governing the accumulation and distribution of FIB in a beach aquifer. Field data indicate E. coli and enterococci can be transported 1 and 2 m, respectively, below the water table. Data were used to calibrate a numerical model whereby FIB are delivered to a beach aquifer by wave-induced infiltration across the beach face...
February 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28180191/doppler-ultrasonography-combined-with-transient-elastography-improves-the-non-invasive-assessment-of-fibrosis-in-patients-with-chronic-liver-diseases
#6
Tamara Alempijevic, Simon Zec, Vladimir Nikolic, Aleksandar Veljkovic, Zoran Stojanovic, Vera Matovic, Tomica Milosavljevic
AIMS: Accurate clinical assessment of liver fibrosis is essential and the aim of our study was to compare and combine hemodynamic Doppler ultrasonography, liver stiffness by transient elastography, and non-invasive serum biomarkers with the degree of fibrosis confirmed by liver biopsy, and thereby to determine the value of combining non-invasive method in the prediction significant liver fibrosis. MATERIAL AND METHODS: We included 102 patients with chronic liver disease of various etiology...
January 31, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28177915/fibrinogen-is-related-to-long-term-mortality-in-chinese-patients-with-acute-coronary-syndrome-but-failed-to-enhance-the-prognostic-value-of-the-grace-score
#7
Yong Peng, Tian-Li Xia, Yi-Ming Li, Fang-Yang Huang, Hua Chai, Peng-Ju Wang, Wei Liu, Chen Zhang, Xiao-Bo Pu, Shi-Jian Chen, Mao Chen, De-Jia Huang
Fibrinogen (Fib) is considered to be a potential risk factor for the prognosis of patients with acute coronary syndrome (ACS), but it is unclear whether Fib level have synergistic effects to enhance the prognostic value of the GRACE score in patients with ACS. A retrospective analysis was conducted from a single registered database. 2253 consecutive patients with ACS confirmed by coronary angiography were enrolled and were grouped into 3 categories by the tertiles of admission plasma Fib levels. The end points were all-cause mortality and cardiac mortality...
February 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28177543/changes-in-liver-stiffness-measurements-and-fibrosis-scores-following-sofosbuvir-based-treatment-regimens-without-interferon
#8
Aisha Elsharkawy, Shereen Abdel Alem, Rabab Fouad, Maissa El Raziky, Wafaa El Akel, Mahmoud Abdo, Omnia Tantawi, Mohamed AbdAllah, Marc Bourliere, Gamal Esmat
BACKGROUND AND AIM: Accurate evaluation of the degree of liver fibrosis in patients with chronic liver diseases is crucial, as liver fibrosis is important in order to make therapeutic decisions, determine prognosis of liver disease and to follow-up disease progression. Multiple non-invasive methods have been used successfully in the prediction of fibrosis however early changes in non-invasive biomarkers of hepatic fibrosis under effective antiviral therapy are widely unknown. AIM: To evaluate changes of Transient elastography values as well as FIB-4 and AST to platelet ratio index in patients (APRI) treated with sofosbuvir- based treatment regimen...
February 8, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28170351/observation-of-quantum-oscillations-in-fib-fabricated-nanowires-of-topological-insulator-bi2se3
#9
Biplab Bhattacharyya, Alka Sharma, V P S Awana, A K Srivastava, T D Senguttuvan, Sudhir Husale
In the last few years, research based on topological insulators (TIs) has been of great interest due to their intrinsic exotic fundamental properties and potential applications such as quantum computers or spintronics. The fabrication of TI nanodevices and the study of their transport properties has mostly focused on high quality crystalline nanowires or nanoribbons. Here, we report a robust approach to Bi2Se3 nanowire formation from deposited flakes using an ion beam milling method. Fabricated Bi2Se3 nanowire devices were employed to investigate the robustness of the topological surface state (TSS) to gallium ion doping and any deformation in the material due to the fabrication tools...
March 22, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28166786/chemical-constituents-and-coagulation-activity-of-agastache-rugosa
#10
Pengran Cao, Pingyao Xie, Xuebiao Wang, Jinmei Wang, Jinfeng Wei, Wen-Yi Kang
BACKGROUND: In the Chinese traditional medicine, plant of Agastache rugosa (Fisch. & C.A. Mey.) Kuntze (A. rugosa) has been used to treat nausea, vomiting and dispel damp. However, currently, few reports about the chemical constituents, especially the non-volatile components of A. rugosa are available. METHODS: Through separation with various column chromatographies to elucidate the chemical constituents of A. rugosa, the biological activities of the major constituents were investigated...
February 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28164635/microrna-122-as-a-novel-non-invasive-marker-of-liver-fibrosis-in-hepatitis-c-virus-patients
#11
Ahmed A S Omran, Khalid S Osman, Hanan M Kamel, Emad A Abdel-Naem, Dalia E El-Deen Hasan
BACKGROUND: Noninvasive evaluation of hepatic fibrosis is a growing scientific effort in medicine and is of particular interest as early diagnosis is important for the timely prevention and treatment of liver fibrosis and cirrhosis. Non-invasive markers of liver fibrosis have recently been developed as an alternative to liver biopsy. Aim of the work: The aim of this study was to assess the diagnostic value of serum microRNA 122 in Egyptian chronic hepatitis C virus infected patients. This may be a useful tool as a non invasive diagnostic test to detect early stages of fibrosis in comparison to 4 non invasive indexes (APRI, Forns, FIB-4, and FI) vs...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162119/modern-focused-ion-beam-based-site-specific-specimen-preparation-for-atom-probe-tomography
#12
Ty J Prosa, David J Larson
Approximately 30 years after the first use of focused ion beam (FIB) instruments to prepare atom probe tomography specimens, this technique has grown to be used by hundreds of researchers around the world. This past decade has seen tremendous advances in atom probe applications, enabled by the continued development of FIB-based specimen preparation methodologies. In this work, we provide a short review of the origin of the FIB method and the standard methods used today for lift-out and sharpening, using the annular milling method as applied to atom probe tomography specimens...
February 6, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28159789/cross-comparison-of-human-wastewater-associated-molecular-markers-in-relation-to-fecal-indicator-bacteria-and-enteric-viruses-in-recreational-beach-waters
#13
B Hughes, D Beale, P G Dennis, S Cook, W Ahmed
: Detecting human wastewater contamination in recreational waters is of critical importance to regulators due to the risks posed to public health. To identify such risks, human wastewater associated microbial source tracking (MST) markers have been developed. At present, however, greater understanding of the suitability of these markers for the detection of diluted human wastewater in environmental waters is necessary to predict risk. Here, we compared the process limit of detection (PLOD) and quantification (PLOQ) of six human wastewater associated MST markers [Bacteroides HF183 (HF183), E...
February 3, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28159767/ticagrelor-reversal-in-vitro-assessment-of-four-haemostatic-agents
#14
Leyla Calmette, Anne-Céline Martin, Bernard Le Bonniec, Diane Zlotnik, Isabelle Gouin-Thibault, Christilla Bachelot-Loza, Pascale Gaussem, Anne Godier
AIM: Management of ticagrelor-induced bleeding is challenging as platelet transfusion is ineffective. An effective strategy is needed. This study aimed to investigate in vitro the efficacy of four haemostatic drugs (HDs), namely recombinant activated factor VII (rFVIIa), fibrinogen concentrate (Fib), tranexamic acid (TXA) and factor XIII concentrate (FXIII) to improve the haemostatic capacity in the presence of ticagrelor. METHODS: Blood was spiked with ticagrelor then supplemented by either HD or control...
February 3, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28138862/the-promis-fatigue-item-bank-has-good-measurement-properties-in-patients-with-fibromyalgia-and-severe-fatigue
#15
Kathleen J Yost, Niels G Waller, Minji K Lee, Ann Vincent
PURPOSE: Efficient management of fibromyalgia (FM) requires precise measurement of FM-specific symptoms. Our objective was to assess the measurement properties of the Patient-Reported Outcome Measurement Information System (PROMIS) fatigue item bank (FIB) in people with FM. METHODS: We applied classical psychometric and item response theory methods to cross-sectional PROMIS-FIB data from two samples. Data on the clinical FM sample were obtained at a tertiary medical center...
January 30, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28130852/a-novel-noninvasive-algorithm-for-the-assessment-of-liver-fibrosis-in-patients-with-chronic-hepatitis-b-virus-infection
#16
Ming-Yu Zhu, Xia Zou, Qiang Li, De-Min Yu, Zhi-Tao Yang, Dao Huang, Jie Chen, Qi-Ming Gong, Dong-Hua Zhang, Yan Zhang, Liang Chen, Pei-Zhan Chen, Xin-Xin Zhang
Several noninvasive blood biomarkers have been established for the assessment of liver fibrosis in patients with chronic hepatitis B virus (HBV) infection, but their clinical performance remains inconclusive. Here, we compared the diagnostic performance of these biomarkers and developed a novel algorithm for assessing liver fibrosis. Six hundred and sixteen chronic HBV-infected and treatment-naïve patients who underwent liver biopsy were enrolled and randomly divided into training (N = 410) and internal validation cohorts (N = 206)...
January 27, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28127890/microrna-profile-analysis-in-the-liver-fibrotic-tissues-of-chronic-hepatitis-b-patients
#17
Rong Chen, Jun-Cheng Wu, Ting Liu, Ying Qu, Lun-Gen Lu, Ming-Yi Xu
OBJECTIVE: The miRNAs play an important role in the development of human fibrosis diseases. However, the mechanisms of miRNA related to liver fibrosis are not fully exploited. Our study aims to identify the miRNAs features during fibrotic stage S0 to S4,which would be associated with hepatitis B virus (HBV) related liver fibrosis. METHED: Liver tissues were collected from 40 chronic hepatitis B (CHB) patients with fibrotic from stage S0 to S4. Microarray of miRNA and genomic informatics analysis were performed...
January 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28124499/stem-and-hrtem-studies-of-accumulated-deposits-on-human-tooth-surface
#18
Masanobu Wakasa, Yoshiyuki Eshita, Kuniyuki Nakanishi, Tsutomu Isobe, Kenji Manago, Masayuki Okamoto, Toshiyuki Isshiki
The aim of this study was to clarify the fine structure of accumulated deposits on the surface of teeth that are considered to affect the gloss of teeth. The study was carried out using, as specimens, human incisor teeth having gloss, which were extracted from teenage donors and those incapable of showing gloss even by brushing which were extracted from donors in their 50s. Thin longitudinal sections of tooth enamel with accumulated deposits on the surface were prepared by focused ion beam (FIB) milling, and the fine structure was analyzed using a scanning transmission electron microscope (STEM) and a high resolution transmission electron microscope (HRTEM)...
January 25, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28120460/ultrastructure-of-ellipsoidal-magnetotactic-multicellular-prokaryotes-depicts-their-complex-assemblage-and-cellular-polarity-in-the-context-of-magnetotaxis
#19
Pedro Leão, Yi-Ran Chen, Fernanda Abreu, Mingling Wang, Wei-Jia Zhang, Ke Zhou, Tian Xiao, Long-Fei Wu, Ulysses Lins
Magnetotactic multicellular prokaryotes (MMPs) consist of unique microorganisms formed by genetically identical Gram-negative bacterial that live as a single individual capable of producing magnetic nano-particles called magnetosomes. Two distinct morphotypes of MMPs are known: spherical MMPs (sMMPs) and ellipsoidal MMPs (eMMPs). sMMPs have been extensively characterized, but less information exists for eMMPs. Here, we report the ultrastructure and organization as well as gene clusters responsible for magnetosome and flagella biosynthesis in the magnetite magnetosome producer eMMP Candidatus Magnetananas rongchenensis...
January 24, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28104518/evaluation-of-the-dry-and-wet-weather-recreational-health-risks-in-a-semi-enclosed-marine-embayment-in-southern-california
#20
Keah-Ying Lim, Stella Shao, Jian Peng, Stanley B Grant, Sunny C Jiang
For many coastal regions around the world, recreational beach water quality is assessed using fecal indicator bacteria (FIB). However, the utility of FIB as indicators of recreational water illness (RWI) risk has been questioned, particularly in coastal settings with no obvious sources of human sewage. In this study we employed a source-apportionment quantitative microbial risk assessment (SA-QMRA) to assess RWI risk at a popular semi-enclosed recreational beach in Southern California (Baby Beach, City of Dana Point) with no obvious point sources of human sewage...
January 4, 2017: Water Research
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