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Low levels monoclonal igm

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https://www.readbyqxmd.com/read/28768852/septic-episodes-in-a-premature-infant-after-in-utero-exposure-to-rituximab
#1
Susanne Hay, Sandra Burchett, Oreofe Odejide, Sule Cataltepe
Rituximab is an increasingly used immunotherapeutic agent for women of reproductive age for treatment of autoimmune diseases, leukemias, and lymphomas. Rituximab is a chimeric monoclonal antibody that targets B-cell surface antigen CD20 and can cross the placenta. Current evidence of the impact of this medication on the developing fetus is limited, but there is little to suggest that fetal exposure to this medication places an infant at increased risk of immunosuppression and subsequent infection. Here we report a case of in utero rituximab exposure that was associated with 2 severe septic episodes with Enterococcus faecalis, in a premature infant of 29 weeks' gestational age with a birth weight of 820 g...
August 2, 2017: Pediatrics
https://www.readbyqxmd.com/read/28602036/circulating-adiponectin-levels-differ-between-patients-with-multiple-myeloma-and-its-precursor-disease
#2
Jonathan N Hofmann, Sham Mailankody, Neha Korde, Ye Wang, Nishant Tageja, Rene Costello, Adriana Zingone, Malin Hultcrantz, Michael N Pollak, Mark P Purdue, Ola Landgren
OBJECTIVE: An increased risk of multiple myeloma (MM) has been observed among individuals with low prediagnostic circulating levels of adiponectin, a metabolic hormone that is typically underexpressed among those with overweight or obesity. To assess whether adiponectin may influence myeloma development or progression to frank MM, circulating adiponectin levels were compared across patients with different stages of MM and its precursor, monoclonal gammopathy of undetermined significance (MGUS)...
June 11, 2017: Obesity
https://www.readbyqxmd.com/read/28545410/combined-proximal-tubulopathy-crystal-storing-histiocytosis-and-cast-nephropathy-in-a-patient-with-light-chain-multiple-myeloma
#3
Chung-Kuan Wu, An-Hang Yang, Hung-Chih Lai, Bing-Shi Lin
BACKGROUND: The diagnosis of myeloma, a plasma dyscrasia, often results from the workup of unexplained renal disease. Persistent renal failure in myeloma is commonly caused by tubular nephropathy due to circulating immunoglobulins and free light chains. Myeloma cast nephropathy is characterized by crystalline precipitates of monoclonal light chains within distal tubules. Immunoglobulin crystallization rarely occurs intracellularly, within proximal tubular cells (light chain proximal tubulopathy) and interstitial histiocytes (crystal-storing histiocytosis)...
May 25, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28416698/selective-in-vivo-removal-of-pathogenic-anti-mag-autoantibodies-an-antigen-specific-treatment-option-for-anti-mag-neuropathy
#4
Ruben Herrendorff, Pascal Hänggi, Hélène Pfister, Fan Yang, Delphine Demeestere, Fabienne Hunziker, Samuel Frey, Nicole Schaeren-Wiemers, Andreas J Steck, Beat Ernst
Anti-MAG (myelin-associated glycoprotein) neuropathy is a disabling autoimmune peripheral neuropathy caused by monoclonal IgM autoantibodies that recognize the carbohydrate epitope HNK-1 (human natural killer-1). This glycoepitope is highly expressed on adhesion molecules, such as MAG, present in myelinated nerve fibers. Because the pathogenicity and demyelinating properties of anti-MAG autoantibodies are well established, current treatments are aimed at reducing autoantibody levels. However, current therapies are primarily immunosuppressive and lack selectivity and efficacy...
May 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28380667/antibodies-to-cyclic-citrullinated-peptides-in-patients-with-juvenile-idiopathic-arthritis-and-patients-with-rheumatoid-arthritis-shared-expression-of-the-inherently-autoreactive-9g4-idiotype
#5
Hannah Peckham, Geraldine Cambridge, Lauren Bourke, Debajit Sen, Anna Radziszewska, Maria Leandro, Yiannis Ioannou
OBJECTIVE: Antibodies to cyclic citrullinated peptides (anti-CCP) in rheumatoid arthritis (RA) can express the inherently autoreactive gene VH 4-34, detected using the rat monoclonal antibody 9G4. Patients with the polyarticular subtype of juvenile idiopathic arthritis (JIA) share some but not all of the features of adult patients with RA. This study was undertaken to compare serologic findings for rheumatoid factor (RF), anti-CCP, and 9G4-expressing anti-CCP in a large JIA cohort with a cohort of adult RA patients...
April 5, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27804292/analysis-of-pre-existing-igg-and-igm-antibodies-against-polyethylene-glycol-peg-in-the-general-population
#6
Qi Yang, Timothy M Jacobs, Justin D McCallen, Dominic T Moore, Justin T Huckaby, Jasmine N Edelstein, Samuel K Lai
Circulating antibodies (Ab) that specifically bind polyethylene glycol (PEG), a biocompatible polymer routinely used in protein and nanoparticle therapeutics, have been associated with reduced efficacy of and/or adverse reactions to therapeutics modified with or containing PEG. Unlike most antidrug antibodies that are induced following initial drug dosing, anti-PEG Ab can be found in treatment-naïve individuals (i.e., individuals who have never undergone treatment with PEGylated drugs but most likely have been exposed to PEG through other means)...
December 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27725289/virologic-clinical-and-immune-response-outcomes-of-patients-with-hepatitis-c-virus-associated-cryoglobulinemia-treated-with-direct-acting-antivirals
#7
Martín Bonacci, Sabela Lens, María-Carlota Londoño, Zoe Mariño, Maria C Cid, Manuel Ramos-Casals, Jose María Sánchez-Tapias, Xavier Forns, José Hernández-Rodríguez
BACKGROUND & AIMS: Cryoglobulins (circulating immune complexes of polyclonal IgG, monoclonal IgM, and rheumatoid factor) are detected in the circulation of 40% to 60% of patients with chronic hepatitis C virus infection, and cryoglobulinemic vasculitis (CV) is observed in approximately 10% of patients. We aimed to assess the clinical and immune effects of direct-acting antiviral treatment. METHODS: We performed a prospective study of 64 patients with HCV infection with circulating cryoglobulins receiving direct-acting antiviral therapy at a single center in Barcelona, Spain, from January 2014 through April 2016...
April 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27701752/immunotherapy-for-igm-anti-myelin-associated-glycoprotein-paraprotein-associated-peripheral-neuropathies
#8
REVIEW
Michael Pt Lunn, Eduardo Nobile-Orazio
BACKGROUND: Serum monoclonal anti-myelin-associated glycoprotein (anti-MAG) antibodies may be pathogenic in some people with immunoglobulin M (IgM) paraprotein and demyelinating neuropathy. Immunotherapies aimed at reducing the level of these antibodies might be expected to be beneficial. This is an update of a review first published in 2003 and previously updated in 2006 and 2012. OBJECTIVES: To assess the effects of immunotherapy for IgM anti-MAG paraprotein-associated demyelinating peripheral neuropathy...
October 4, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27627660/anti-human-platelet-antigen-1a-immunoglobulin-g-preparation-intended-to-prevent-fetal-and-neonatal-alloimmune-thrombocytopenia
#9
Ying-Jan Weng, Anne Husebekk, Björn Skogen, Mette Kjaer, Liang-Tzung Lin, Thierry Burnouf
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a severe disease that is caused by maternal alloantibodies generated during pregnancy or at delivery as a result of incompatibility between maternal and fetal human platelet antigens (HPAs) inherited from the father. Antibody-mediated immune suppression using anti-HPA-1a immunoglobulins is thought to be able to prevent FNAIT caused by HPA-1a. A fractionation process to prepare anti-HPA-1a immunoglobulin (Ig) G (IgG) from human plasma was therefore developed...
2016: PloS One
https://www.readbyqxmd.com/read/27319233/-treatment-with-rituximab-as-an-opportunity-for-the-prevention-of-infectious-complications
#10
Pavel Polák, Miroslav Penka, Petr Smejkal, Gabriela Chlupová
UNLABELLED: Rituximab, a monoclonal antibody against the surface antigen of B-lymphocytes CD20 is beeing used in the treatment of numerous hematological, hematooncological and autoimmune disorders. After administration of ritu-ximab, quick and almost complete depletion of B-lymphocytes with the exception of pre-B-lymphocytes and plasma cells occur. Neutropenia and low serum antibody levels in classes IgA, IgM and IgG may also develop. These changes usually persist for 6-12 months, rarely for several years...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/26951330/development-of-a-duplex-rapid-assay-for-immunoglobulins-m-and-g-to-evaluate-the-parvoviral-immune-status-of-clinically-healthy-dogs
#11
Marco Palma, Nuria de la Roja, Mercedes Montón, Patricia Sastre, Susana Ramírez, Belén Barreiro, Angel Venteo, Paloma Rueda
A duplex rapid assay for detection of serum antibodies to canine parvovirus (CPV) was developed. Canine immunoglobulin (Ig)M or IgG were captured in immunotubes with anti-canine IgM or IgG and detected with parvovirus VP2 recombinant protein followed by an anti-VP2 monoclonal antibody. The assay was tested using a collection of sera from dogs that were vaccinated against CPV on arrival at an animal shelter in Madrid, Spain. Results were compared with those of 2 commercial enzyme-linked immunosorbent assays (ELISAs) considered as reference techniques...
May 2016: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/26892336/simultaneous-occurrence-of-fibrillary-glomerulonephritis-and-renal-lesions-in-nonmalignant-monoclonal-igm-gammopathy
#12
Chung-Kuan Wu, Jyh-Gang Leu, An-Hang Yang, Der-Cherng Tarng, Hsiang-Yuen Tung, Shou-Shan Chiang
BACKGROUND: Fibrillary glomerulonephritis (FGN) is a rare primary glomerular disease that seldom coexists with other diseases. Membranoproliferative glomerulonephritis is a pathologic finding of renal lesions associated with IgM-secreting monoclonal proliferations. We present a case study of a patient with unusual simultaneous FGN and IgM-related renal disorder in nonmalignant monoclonal IgM gammopathy. CASE PRESENTATION: A 63-year-old male presented with nephrotic syndrome and elevated serum creatinine levels...
February 18, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/26686246/next-generation-igvh-sequencing-cll-like-monoclonal-b-cell-lymphocytosis-reveals-frequent-oligoclonality-and-ongoing-hypermutation
#13
M Klinger, J Zheng, K S J Elenitoba-Johnson, S L Perkins, M Faham, D W Bahler
Chronic lymphocytic leukemia (CLL) develops from CLL-like monoclonal B-cell lymphocytosis (MBL) which represents a low-level asymptomatic expansion of cells that phenotypically resemble CLL. Although antigen selection plays a key role during CLL development, it is not known whether this occurs in early MBL or only during progression to CLL. Recent studies suggested that MBL sometimes displays oligoclonality, but these used techniques with limited sensitivity and specificity and were not conclusive. In this study, we combine cell sorting and next-generation sequencing of rearranged immunoglobulin heavy chain variable (IgVH) genes to thoroughly assess the VH repertoire and oligoclonality of purified MBL cells...
May 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/26278155/immunoparesis-in-mgus-relationship-of-uninvolved-immunoglobulin-pair-suppression-and-polyclonal-immunoglobuline-levels-to-mgus-risk-categories
#14
T Pika, P Lochman, V Sandecka, V Maisnar, J Minarik, M Tichy, J Zapletalova, L Solcova, V Scudla, R Hajek
Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic, potentially malignant condition. It has been established that annually approximately 1-2% of MGUS cases transforms into one of the malignant forms of monoclonal gammopathies. Progression risk factors include the quantity and type of M-protein, and namely the ratio of free light immunoglobulin chains (FLC). These factors, enable purposeful stratification of MGUS individuals. Some authors consider suppression of polyclonal immunoglobulin levels to be another progression factor...
2015: Neoplasma
https://www.readbyqxmd.com/read/26064133/disseminated-gastric-malt-lymphoma-with-monoclonal-gammopathy-t-11-18-q21-q21-and-subsequent-development-of-t-large-granular-lymphocytic-leukemia-a-case-report-and-review-of-the-literature
#15
Riad Akoum, Wassim Serhal, Hussein Farhat
Background. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is a well-characterized entity that may share clinical and morphological findings with other low-grade non-Hodgkin's lymphomas. Dissemination of MALT-type lymphoma to bone marrow and peripheral blood simultaneously with the presence of T-large granular cell leukemia (T-LGL) has rarely been reported. Case Presentation. This is the case of a 42-year-old male who presented with a gastric MALT-type lymphoma, disseminated to the bone marrow and the peripheral blood with high serum IgM levels and t(11;18)(q21;q21)...
2015: Case Reports in Medicine
https://www.readbyqxmd.com/read/25359291/soluble-ox40l-is-associated-with-presence-of-autoantibodies-in-early-rheumatoid-arthritis
#16
Julie K Laustsen, Tue K Rasmussen, Kristian Stengaard-Pedersen, Kim Hørslev-Petersen, Merete L Hetland, Mikkel Østergaard, Peter Junker, Malene Hvid, Bent Deleuran
INTRODUCTION: OX40 and its ligand OX40L are key components in the generation of adaptive memory response and provide necessary co-stimulatory signals for activated effector T cells. Here we investigate the dual roles of the membrane and soluble (s) forms of OX40 and OX40L in plasma and synovial fluid and their association with autoantibodies and disease activity in rheumatoid arthritis (RA). METHODS: Soluble OX40 and sOX40L plasma levels were measured in treatment-naïve early RA patients (eRA) at baseline and after 3, 6, and 12 months of treatment with methotrexate and adalimumab (n = 39) and with methotrexate alone (n = 37)...
October 30, 2014: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25176210/-establishment-and-evaluation-of-enzyme-linked-immunosorbent-assay-for-measuring-human-igm-autoantibody-to-folate-receptor
#17
Na Yang, Lin-lin Wang, Yue Yuan, Rong-wei Ye, Ai-guo Ren
OBJECTIVE: To establish the method of enzyme-linked immunosorbent assay (ELISA) for measuring human IgM autoantibody to folate receptor. METHODS: Folate receptor was extracted and purified from the healthy woman placenta. The protein was coated on 96-well plates with a concentration of 5 ng/Μl. Goat monoclonal antibody was used for detecting antibody. Pooled plasma from healthy donors was used to plot the standard curve and the IgM concentration of pooled plasma was defined as 1...
August 2014: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/25167227/the-glycosphingolipid-p%C3%A2-is-an-ovarian-cancer-associated-carbohydrate-antigen-involved-in-migration
#18
F Jacob, M Anugraham, T Pochechueva, B W C Tse, S Alam, R Guertler, N V Bovin, A Fedier, N F Hacker, M E Huflejt, N Packer, V A Heinzelmann-Schwarz
BACKGROUND: The level of plasma-derived naturally circulating anti-glycan antibodies (AGA) to P1 trisaccharide has previously been shown to significantly discriminate between ovarian cancer patients and healthy women. Here we aim to identify the Ig class that causes this discrimination, to identify on cancer cells the corresponding P1 antigen recognised by circulating anti-P1 antibodies and to shed light into the possible function of this glycosphingolipid. METHODS: An independent Australian cohort was assessed for the presence of anti-P1 IgG and IgM class antibodies using suspension array...
October 14, 2014: British Journal of Cancer
https://www.readbyqxmd.com/read/25080789/-the-immunologic-predictors-of-effect-of-anti-b-cell-therapy-under-rheumatoid-arthritis
#19
A S Avdeeva, E N Aleksandrova, A A Novikov, M V Cherkasova, E L Nasonov
The article deals with results of study targeted to reveal laboratory biomarkers which can be useful in prognosis of effectiveness of rituximab therapy under rheumatoid arthritis. The sampling consisted of 34 patients with rheumatoid arthritis (31 women, average age 49 years, 42-64 years, mean duration of disease 66, 36-132 months). All patients were examined and received two infusions of rituximab intravenously with interval in 2 weeks against the background of standard therapy. The serum concentration of C-reactive protein, IgM rheumatoid factor IgG, IgM, IgA were measured using immune nephelometric method...
March 2014: Klinicheskaia Laboratornaia Diagnostika
https://www.readbyqxmd.com/read/24978830/requirement-of-b7-h1-in-mesenchymal-stem-cells-for-immune-tolerance-to-cardiac-allografts-in-combination-therapy-with-rapamycin
#20
Hao Wang, Feng Qi, Xiangchen Dai, Weijun Tian, Tong Liu, Hongqiu Han, Bai Zhang, Hongyue Li, Zhixiang Zhang, Caigan Du
BACKGROUND: The potential of mesenchymal stem cells (MSCs) for immunosuppression has been tested in transplantation, but its mechanisms are not fully understood. This study investigated the role of MSC-expressing B7-H1 in the induction of immune tolerance to cardiac allografts by the combination therapy of MSCs and rapamycin (RAPA). METHODS: The anti-alloimmunity of donor MSCs in the presence or absence of RAPA was examined in both mouse cardiac allograft model (C57BL/6 to BALB/c mice) and a variety of cultured immune cells...
August 2014: Transplant Immunology
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