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( weight change OR intentional weight change) AND ( coronary events OR death)

Joseph A Ladapo, Udo Hoffmann, Kerry L Lee, Adrian Coles, Megan Huang, Daniel B Mark, Rowena J Dolor, Robert A Pelberg, Matthew Budoff, Gardar Sigurdsson, Harry W Severance, Pamela S Douglas
BACKGROUND: Diagnostic testing in the care of patients newly presenting with symptoms suggestive of coronary artery disease may influence risk factor management, independent of test type or test results. However, little is known about changes in medications and lifestyle after anatomical or functional testing. METHODS AND RESULTS: We examined what factors influenced preventive medical therapy and lifestyle practices at 60 days among 10 003 symptomatic patients (53% women; mean age 61 years) randomly assigned to anatomical testing with coronary computed tomographic angiography or functional testing (NCT01174550)...
October 12, 2016: Journal of the American Heart Association
Rishi Puri, Stephen J Nicholls, Julie St John, E Murat Tuzcu, Samir R Kapadia, Kiyoko Uno, Yu Kataoka, Kathy Wolski, Steven E Nissen
We explored for geographic variations in coronary atheroma progression rates in the United States compared to other world regions (Canada, Latin America, Western Europe, and Central-Eastern Europe) and sought to ascertain if this associated with regional differences in major adverse cardiovascular events (MACE; cardiovascular death, nonfatal myocardial infarction, coronary revascularization). Across 7 randomized trials with a global recruitment pattern, 5,451 participants with angiographic coronary disease underwent serial coronary intravascular ultrasonography during 18 or 24 months, with adjudicated MACE...
August 31, 2016: American Journal of Cardiology
(no author information available yet)
BACKGROUND: Findings from the Look AHEAD trial showed no significant reductions in the primary outcome of cardiovascular disease incidence in adults with type 2 diabetes randomly assigned to an intensive lifestyle intervention for weight loss compared with those randomly assigned to diabetes support and education (control). We examined whether the incidence of cardiovascular disease in Look AHEAD varied by changes in weight or fitness. METHODS: Look AHEAD was a randomised clinical trial done at 16 clinical sites in the USA, recruiting patients from Aug 22, 2001, to April 30, 2004...
August 30, 2016: Lancet Diabetes & Endocrinology
Colin R Lenihan, Maria E Montez-Rath, Wolfgang C Winkelmayer, Tara I Chang
BACKGROUND: The comparative effectiveness of percutaneous coronary intervention (PCI) with drug eluting stents (DES) versus bare metal stents (BMS) has not been studied in the kidney transplant population. METHODS: Using the US Renal Data System, we identified 3245 kidney transplant patients who underwent PCI between April 2003 and December 2010; 2400 and 845 patients received DES and BMS, respectively. We used propensity score-matching and inverse probability of treatment weighting (IPTW) to create DES- and BMS-treated groups whose observed baseline characteristics were well-balanced...
August 11, 2016: Transplantation
Pamela S Douglas, Bernard De Bruyne, Gianluca Pontone, Manesh R Patel, Bjarne L Norgaard, Robert A Byrne, Nick Curzen, Ian Purcell, Matthias Gutberlet, Gilles Rioufol, Ulrich Hink, Herwig Walter Schuchlenz, Gudrun Feuchtner, Martine Gilard, Daniele Andreini, Jesper M Jensen, Martin Hadamitzky, Karen Chiswell, Derek Cyr, Alan Wilk, Furong Wang, Campbell Rogers, Mark A Hlatky
BACKGROUND: Coronary computed tomographic angiography (CTA) plus estimation of fractional flow reserve using CTA (FFRCT) safely and effectively guides initial care over 90 days in patients with stable chest pain. Longer-term outcomes are unknown. OBJECTIVES: The study sought to determine the 1-year clinical, economic, and quality-of-life (QOL) outcomes of using FFRCT instead of usual care. METHODS: Consecutive patients with stable, new onset chest pain were managed by either usual testing (n = 287) or CTA (n = 297) with selective FFRCT (submitted in 201, analyzed in 177); 581 of 584 (99...
August 2, 2016: Journal of the American College of Cardiology
Amirhossein Sahebkar, Renato Giua, Claudio Pedone, Kausik K Ray, Antonio J Vallejo-Vaz, Luisa Costanzo
Flow-mediated dilation (FMD) of the brachial artery reflects endothelium-dependent vasodilator function; since it correlates with coronary endothelial function, its reduction could predict cardiovascular events. Several studies have investigated the potential impact of fibrates therapy on endothelial function, but clinical findings have not been fully consistent. We aimed to conduct a meta-analysis of randomized placebo-controlled trials in order to clarify whether fibrate therapy could improve endothelial function...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
C Finelli, P Crispino, S Gioia, N La Sala, L D'amico, M La Grotta, O Miro, D Colarusso
Depressed levels of atheroprotective large HDL particles are common in obesity and cardiovascular disease (CVD). Increases in large HDL particles are favourably associated with reduced CVD event risk and coronary plaque burden. The objective of the study is to compare the effectiveness of low-carbohydrate diets and weight loss for increasing blood levels of large HDL particles at 1 year. This study was performed by screening for body mass index (BMI) and metabolic syndrome in 160 consecutive subjects referred to our out-patient Metabolic Unit in South Italy...
2016: EXCLI journal
Sung Min Ko, Chao Zhang, Zhengjia Chen, Luis D'Marco, Antonio Bellasi, Arthur E Stillman, Geoffrey Block, Paolo Raggi
BACKGROUND: In the general population and in hemodialysis patients epicardial adipose tissue (EAT) has been associated with increased mortality and cardiovascular events. Weight loss and lipid lowering therapies reduced EAT in the general population. It is unknown whether sevelamer, a phosphate (Pi) binder that lowers cholesterol and reduces inflammation in dialysis patients also affects EAT progression. METHODS: Post-hoc analysis of a randomized trial of sevelamer (SVL) versus calcium-based Pi binders (CPiB) in incident hemodialysis patients...
October 2016: Journal of Nephrology
Narendra Singh, Milan Gupta
Randomized clinical trials (RCTs) remain the foundation for assessing and introducing evidence-based therapies into cardiovascular (CV) medicine. In 2015, a number of RCTs were reported and published that have great potential to improve CV outcomes and thus to change clinical practice. We highlight the results and implications of major RCTs in the areas of acute coronary syndrome (ACS), interventional cardiology, atrial fibrillation, lipids, heart failure, diabetes, and hypertension. Among the trials we discuss, PEGASUS and DAPT provide guidance regarding the potential benefits and hazards of longer-term dual-antiplatelet therapy after percutaneous coronary intervention (PCI) or myocardial infarction (MI)...
August 2016: Canadian Journal of Cardiology
E Bonora, B Bryzinski, B Hirshberg, W Cook
BACKGROUND AND AIMS: To assess the efficacy and safety of saxagliptin 2.5 and 5 mg/d in patients with type 2 diabetes mellitus (T2DM) and high risk of coronary heart disease (CHD) or stroke as estimated by the United Kingdom Prospective Diabetes Study (UKPDS) risk engine. METHODS AND RESULTS: Post hoc analysis of data pooled from 5 previously reported phase 3, randomized, placebo-controlled, 24-week studies was conducted. Patients were stratified into subgroups by UKPDS 10-year CHD and/or stroke risk ≥20% and CHD and stroke risk <20%...
May 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Xin Zheng, Jeptha P Curtis, Shuang Hu, Yongfei Wang, Yuejin Yang, Frederick A Masoudi, John A Spertus, Xi Li, Jing Li, Kumar Dharmarajan, Nicholas S Downing, Harlan M Krumholz, Lixin Jiang
IMPORTANCE: The use of coronary catheterization and percutaneous coronary intervention (PCI) is increasing in China, but, to date, there are no nationally representative assessments of the quality of care and outcomes in patients undergoing these procedures. OBJECTIVE: To assess the quality of care and outcomes of patients undergoing coronary catheterization and PCI in China. DESIGN, SETTING, AND PARTICIPANTS: In a clinical observational study (China PEACE [Patient-Centered Evaluative Assessment of Cardiac Events]-Retrospective CathPCI Study), we used a 2-stage, random sampling strategy to create a nationally representative sample of 11 241 patients undergoing coronary catheterization and PCI at 55 urban Chinese hospitals in calendar years 2001, 2006, and 2011...
April 2016: JAMA Internal Medicine
Marco Springmann, Daniel Mason-D'Croz, Sherman Robinson, Tara Garnett, H Charles J Godfray, Douglas Gollin, Mike Rayner, Paola Ballon, Peter Scarborough
BACKGROUND: One of the most important consequences of climate change could be its effects on agriculture. Although much research has focused on questions of food security, less has been devoted to assessing the wider health impacts of future changes in agricultural production. In this modelling study, we estimate excess mortality attributable to agriculturally mediated changes in dietary and weight-related risk factors by cause of death for 155 world regions in the year 2050. METHODS: For this modelling study, we linked a detailed agricultural modelling framework, the International Model for Policy Analysis of Agricultural Commodities and Trade (IMPACT), to a comparative risk assessment of changes in fruit and vegetable consumption, red meat consumption, and bodyweight for deaths from coronary heart disease, stroke, cancer, and an aggregate of other causes...
May 7, 2016: Lancet
Man-shik Shim, Tae-Gook Jun, Ji-Hyuk Yang, Pyo Won Park, I Seok Kang, June Huh, Jin Young Song
BACKGROUND: We reviewed our 20-year experience with arterial switch operation (ASO) for transposition of the great arteries (TGA) or double outlet right ventricle with subpulmonary ventricular septal defect (Taussig-Bing anomaly) to assess the early and long-term outcomes. METHODS: Between January 1995 and December 2014, 139 consecutive patients who underwent ASO for TGA or Taussig-Bing anomaly were included in this retrospective study. The median age at the operation was 9 (0-485) days, and 97 patients (70 %) underwent ASO less than 2 weeks...
February 24, 2016: Journal of Cardiothoracic Surgery
Ann D Smith, Alexander T Hawkins, Maria J Schaumeier, Marit S de Vos, Michael S Conte, Louis L Nguyen
OBJECTIVE: Despite patent vein bypass grafts, some patients with critical limb ischemia (CLI) receive major amputations. We analyzed the predictive factors leading to major amputation in the presence of patent lower extremity bypass (LEB) grafts. METHODS: Data from the Project of Ex-Vivo vein graft Engineering via Transfection III (PREVENT III), a large prospective randomized trial of 1404 patients who underwent LEB with vein graft for CLI, were queried for outcomes...
May 2016: Journal of Vascular Surgery
Yoichiro Hirakawa, Tai-Hing Lam, Timothy Welborn, Hyeon Chang Kim, Suzanne Ho, Xianghua Fang, Hirotsugu Ueshima, Il Suh, Graham Giles, Mark Woodward
OBJECTIVE: To assess whether body mass index (BMI) modifies the associations of lipids with coronary heart disease (CHD). METHODS: In the Asia Pacific Cohort Studies Collaboration, total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and triglycerides (TG) were measured for 333,297, 71,777 and 84,015 participants, respectively. All participants had measured BMI, categorized into underweight, normal, high-normal, overweight and obese, using standard definitions...
June 2016: Preventive Medicine Reports
Yvonne L Eaglehouse, Evelyn O Talbott, Yuefang Chang, Lewis H Kuller
IMPORTANCE: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease with no known cause. Case studies primarily of athletes and several case-control studies have suggested that high levels of strenuous physical activity (PA) may increase the risk for ALS. This relationship has yet to be evaluated among women in population-based cohort studies. OBJECTIVE: To evaluate the relationship between PA and risk for ALS mortality in a large cohort of postmenopausal women...
March 2016: JAMA Neurology
Franziska Regenass-Lechner, Roland F Staack, Jean-Luc Mary, Wolfgang F Richter, Michael Winter, Gregor Jordan, Nicole Justies, Anja Langenkamp, Rosario Garrido, Mudher Albassam, Thomas Singer, Elke-Astrid Atzpodien
High density lipoprotein (HDL)-targeted therapies, which promote cholesterol efflux from cells, are currently in development for reducing cardiovascular events in acute coronary syndrome. Human apolipoprotein A-I (apoA-I), the major HDL protein, was fused to the trimerization domain of tetranectin (TN) and complexed with phospholipids to generate a HDL mimetic (lipidated TN-ApoA-I) with reduced renal clearance and enhanced efficacy. Cynomolgus monkeys received 24-h intravenous infusions of control, 100 mg/kg or 400 mg/kg lipidated TN-ApoA-I every 4 days for 3 weeks, followed by a 6-week recovery period...
April 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
Donghui Li, Yixiang Mao, Ping Chang, Chang Liu, Manal M Hassan, Saiching J Yeung, James L Abbruzzese
Patients with pancreatic cancer have a high frequency of concurrent diabetes. This study is aimed to demonstrate the impact of diabetes on clinical outcome of pancreatic cancer. Clinical and epidemiological information was collected from medical records or by personal interview in 1328 patients with pancreatic ductal adenocarcinoma. Diabetes was defined by a known medical history, or abnormal fasting blood glucose (FBG) and HbA1c levels within three months of the cancer diagnosis. Duration of ≤3 years was used as the cutoff to arbitrarily define the new-onset and long-term diabetes...
2015: American Journal of Cancer Research
Goodarz Danaei, James M Robins, Jessica G Young, Frank B Hu, JoAnn E Manson, Miguel A Hernán
BACKGROUND: Evidence for the effect of weight loss on coronary heart disease (CHD) or mortality has been mixed. The effect estimates can be confounded due to undiagnosed diseases that may affect weight loss. METHODS: We used data from the Nurses' Health Study to estimate the 26-year risk of CHD under several hypothetical weight loss strategies. We applied the parametric g-formula and implemented a novel sensitivity analysis for unmeasured confounding due to undiagnosed disease by imposing a lag time for the effect of weight loss on chronic disease...
March 2016: Epidemiology
Panagiotis Antiochos, Pedro Marques-Vidal, Aaron McDaid, Gerard Waeber, Peter Vollenweider
BACKGROUND AND AIMS: Parental history (PH) and genetic risk scores (GRSs) are separately associated with coronary heart disease (CHD), but evidence regarding their combined effects is lacking. We aimed to evaluate the joint associations and predictive ability of PH and GRSs for incident CHD. METHODS: Data for 4283 Caucasians were obtained from the population-based CoLaus Study, over median follow-up time of 5.6 years. CHD was defined as incident myocardial infarction, angina, percutaneous coronary revascularization or bypass grafting...
January 2016: Atherosclerosis
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