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https://www.readbyqxmd.com/read/28799231/efficacy-of-daratumumab-based-therapies-in-patients-with-relapsed-refractory-multiple-myeloma-treated-outside-of-clinical-trials
#1
Arjun Lakshman, Jithma P Abeykoon, Shaji K Kumar, S Vincent Rajkumar, David Dingli, Francis K Buadi, Wilson I Gonsalves, Nelson Leung, Angela Dispenzieri, Taxiarchis V Kourelis, Ronald S Go, Martha Q Lacy, Miriam A Hobbs, Yi Lin, Rahma Warsame, John Lust, Amie L Fonder, Yi L Hwa, Suzanne R Hayman, Stephen J Russell, Robert A Kyle, Morie A Gertz, Prashant Kapoor
Outside of clinical trials, experience with daratumumab-based combination therapies (DCTs) using bortezomib (V)/lenalidomide (R)/pomalidomide (P), and dexamethasone (d) in relapsed/refractory multiple myeloma (RRMM) is limited. We reviewed the outcomes of 126 patients who received ≥ 1 cycle of any DCT. Median age at DCT initiation was 67 (range, 43-93) years. High-risk cytogenetics was present in 33% patients. Median number of prior therapies was 4 (range, 1-14) and time to first DCT from diagnosis was 4...
August 11, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28798969/a-dissipative-particle-dynamics-simulation-study-on-phase-diagrams-for-the-self-assembly-of-amphiphilic-hyperbranched-multiarm-copolymers-in-various-solvents
#2
Haina Tan, Chunyang Yu, Zhongyuan Lu, Yongfeng Zhou, Deyue Yan
Self-assembly of amphiphilic hyperbranched multiarm copolymers (HMCs) has shown great potential for preparing all kinds of delicate supramolecular structures in all scales and dimensions in solution. However, theoretical studies on the influencing factors for the self-assembly of HMCs have been greatly lagging behind. The phase diagram of HMCs in selective solvents is very necessary but has not been disclosed up to now. Here, the self-assembly of HMCs with different hydrophilic fractions in various solvents was studied systematically by using dissipative particle dynamics (DPD) simulations...
August 11, 2017: Soft Matter
https://www.readbyqxmd.com/read/28782462/concentrations-of-ctx-i-ctx-ii-dpd-and-pyd-in-the-urine-as-a-biomarker-for-the-diagnosis-of-temporomandibular-joint-osteoarthritis-a-preliminary-study
#3
Soo-Min Ok, Seung-Min Lee, Hae Ryoun Park, Sung-Hee Jeong, Ching-Chang Ko, Yong-Il Kim
OBJECTIVES: The aim of this study was to identify a marker for temporomandibular joint (TMJ) osteoarthritis (OA) diagnosis by comparing the concentrations of urinary pyridinoline (PYD), deoxypyridinoline (DPD), and C-terminal telopeptides type I collagen (CTX-I), and CTX-II of TMJ OA patients with those of a non-symptomatic group. METHODS: PYD, DPD, CTX-I, and CTX-II concentrations in the urine of 36 non-symptomatic subjects and 31 TMJ OA subjects were analyzed...
August 7, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28756316/dissipative-particle-dynamics-simulations-reveal-the-ph-driven-micellar-transition-pathway-of-monorhamnolipids
#4
Jianchang Xu, ZhiKun Wang, Jianbang Gao, Chunling Li, Shuangqing Sun, Songqing Hu
Dissipative particle dynamics (DPD) simulation has been used to study the effect of pH on the morphology transition of micelles assembled by monorhamnolipids (monoRLs). Results show that micellar structures and transition modes with increasing mass concentrations are multiform due to the changeable hydrophilicity of pH-responsive beads at different pH levels. Various chaotic multilayer aggregations of monoRLs are observed at low pH (pH<4.0) whereas well-ordered single-layer structures are obtained at high pH (pH>7...
July 22, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28728692/magnetic-resonance-in-transthyretin%C3%A2-cardiac-amyloidosis
#5
Ana Martinez-Naharro, Thomas A Treibel, Amna Abdel-Gadir, Heerajnarain Bulluck, Giulia Zumbo, Daniel S Knight, Tushar Kotecha, Rohin Francis, David F Hutt, Tamer Rezk, Stefania Rosmini, Candida C Quarta, Carol J Whelan, Peter Kellman, Julian D Gillmore, James C Moon, Philip N Hawkins, Marianna Fontana
BACKGROUND: Cardiac transthyretin amyloidosis (ATTR) is an increasingly recognized cause of heart failure. Cardiac magnetic resonance (CMR), with late gadolinium enhancement (LGE) and T1 mapping, is emerging as a reference standard for diagnosis and characterization of cardiac amyloidosis. OBJECTIVES: The authors used CMR with extracellular volume fraction (ECV) measurement to characterize cardiac involvement in relation to outcome in ATTR. METHODS: Subjects comprised 263 patients with cardiac ATTR corroborated by grade 2 to 3 (99m)Tc-DPD ((99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) cardiac uptake, 17 with suspected cardiac ATTR (grade 1 (99m)Tc-DPD), and 12 asymptomatic individuals with amyloidogenic transthyretin (TTR) mutations...
July 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28709282/hybrid-smoothed-dissipative-particle-dynamics-and-immersed-boundary-method-for-simulation-of-red-blood-cells-in-flows
#6
Ting Ye, Nhan Phan-Thien, Chwee Teck Lim, Lina Peng, Huixin Shi
In biofluid flow systems, often the flow problems of fluids of complex structures, such as the flow of red blood cells (RBCs) through complex capillary vessels, need to be considered. The smoothed dissipative particle dynamics (SDPD), a particle-based method, is one of the easy and flexible methods to model such complex structure fluids. It couples the best features of the smoothed particle hydrodynamics (SPH) and dissipative particle dynamics (DPD), with parameters having specific physical meaning (coming from SPH discretization of the Navier-Stokes equations), combined with thermal fluctuations in a mesoscale simulation, in a similar manner to the DPD...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28689756/sensorimotor-gating-characteristics-of-violent-men-with-comorbid-psychosis-and-dissocial-personality-disorder-relationship-with-antisocial-traits-and-psychosocial-deprivation
#7
Ottilie Sedgwick, Susan Young, Ben Greer, Jack Arnold, Aisling Parsons, Ignazio Puzzo, Mariafatima Terracciano, Mrigendra Das, Veena Kumari
Evidence suggests violence amongst those with psychosis is not aetiologically homogeneous, and that a large proportion of those who engage in violent behaviour have a comorbid antisocial personality disorder. Initial investigations indicate that this subgroup has distinct historical and neuropsychological characteristics, which may indicate diverse treatment needs. This study investigated sensorimotor gating characteristics of violent men with diagnoses of both psychosis and dissocial personality disorder (DPD) (n=21) relative to violent men with psychosis alone (n=12), DPD alone (n=14) and healthy, non-violent male controls (n=27), using the prepulse inhibition (PPI) paradigm...
July 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28670884/low-incidence-of-the-dpd-ivs14-1g-a-polymorphism-in-jordanian-breast-and-colorectal-cancer-patients
#8
Mohammad Al-Khateeb, Abdalla Awidi, Kamal Al-Hadidi, Abdelkader Battah
Background: Dihydropyrimidine dehydrogenase (DPD) is a crucial enzyme in the catabolism of 5-fluorouracil (5-FU), a drug that is frequently used in cancer therapy. Patients with deficient DPD activity are at risk of developing severe 5-FU–associated toxicity. One possible cause of deficiency is genetic polymorphisms in the DPD gene, such as IVS14+1G>A. Aim: The present study was conducted to screen for the IVS14+1G>A polymorphism in cancer patients receiving 5-FU and a control group. Methods: A total of 40 cancer patients (30 colorectal cancer (CRC) and 10 breast cancer patients) were enrolled in this study...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28669715/lead-substances-selection-using-ghs-approach-for-the-classification-of-mixtures-case-study-of-painting-in-the-work-environment
#9
Kazuhiro Kaneko, Satoko Ishii, Sachio Hosohara, Tsuyoshi Hirata, Motoshi Masuda, Kaori Murasawa, Airi Yamada, Takaaki Tadokoro, Masahiko Hanzawa
We developed a lead substances selection approach based on the concept of mixture classification of UN GHS for the purpose of efficient risk assessment of mixtures consisting of multiple components. Lead substances selection methods are being actively developed in Europe, but these methods are predicated on the regulations and information sources available within Europe and are therefore not readily applicable to countries outside Europe. In this study, the features of the GHS-based approach and the risk assessment results for outdoor painting work as a specific utilization example of the GHS-based approach were described...
June 29, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28669020/expanding-the-digital-protologue-%C3%A2-database-dpd-to-current%C3%A2-microbiology-an-offer-to-scientists-and-science
#10
EDITORIAL
Erko Stackebrandt, David Smith
No abstract text is available yet for this article.
September 2017: Current Microbiology
https://www.readbyqxmd.com/read/28657632/interfacial-adsorption-of-ph-responsive-polymers-and-nanoparticles
#11
Shiyi Qin, Xin Yong
Using dissipative particle dynamics (DPD), we model the interfacial adsorption of pH-responsive polyelectrolytes and polyelectrolyte-grafted nanoparticles (PNPs) at a planar water-oil interface. The electrostatic interactions in the presence of the dielectric discontinuity across the interface are modeled by exploiting the Groot method, which uses an iterative method to solve the Poisson equation on a uniform grid with distributed charge. We reveal the effects of the pH and salinity of the aqueous solution and the length of the polyelectrolyte on the adsorption behavior of weak polyelectrolytes...
August 2, 2017: Soft Matter
https://www.readbyqxmd.com/read/28657106/aqueous-self-assembly-of-hydrophobic-macromolecules-with-adjustable-rigidity-of-the-backbone
#12
Zhou Guan, Dapeng Liu, Jiaping Lin, Xiaosong Wang
P(FpC3P) (Fp: CpFe(CO)2; C3P: propyl diphenyl phosphine) has a helical backbone, resulting from piano stool metal coordination geometry, which is rigid with intramolecular aromatic interaction of the phenyl groups. The macromolecule is hydrophobic, but the polarized CO groups can interact with water for aqueous self-assembly. The stiffness of P(FpC3P), which is adjustable by temperature, is an important factor influencing the morphologies of kinetically trapped assemblies. P(FpC3P)7 self-assembles in DMSO/water (10/90 by volume) into lamellae at 25 °C, vesicles at 40 °C and irregular aggregates at higher temperatures (60 and 70 °C)...
August 2, 2017: Soft Matter
https://www.readbyqxmd.com/read/28652707/development-of-new-promising-antimetabolite-dfp-11207-with-self-controlled-toxicity-in-rodents
#13
Masakazu Fukushima, Kenzo Iizuka, Cheng Jin, Chun Zhang, Mei Hong, Kiyoshi Eshima
To reduce 5-fluorouracil (5-FU)-induced serious toxicities without loss of antitumor activity, we have developed DFP-11207, a novel fluoropyrimidine, which consists of 1-ethoxymethyl-5-fluorouracil (EM-FU; a precursor form of 5-FU), 5-chloro-2,4-dihydroxypyridine (CDHP; an inhibitor of 5-FU degradation), and citrazinic acid (CTA; an inhibitor of 5-FU phosphorylation). In vitro studies of DFP-11207 indicated that it strongly inhibited the degradation of 5-FU by dihydropyrimidine dehydrogenase (DPD) in homogenates of the rat liver, and also inhibited the phosphorylation of 5-FU by orotate phosphoribosyltransferase (OPRT) in tumor tissues in a similar magnitude of potency by CDHP and CTA, respectively...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28638864/protective-effect-of-vanillic-acid-on-ovariectomy-induced-osteoporosis-in-rats
#14
Yong Gui Wang, Liang Bo Jiang, Bo Gou
BACKGROUND: The need for an anti-osteoporotic agent is in high demand since osteoporosis contributes to high rates of disability or impairment (high osteoporotic fracture), morbidity and mortality. Hence, the present study is designed to evaluate the protective effects of vanillic acid (VA) against bilateral ovariectomy-induced osteoporosis in female Sprague-Dawley (SD) rats. MATERIALS AND METHODS: Forty healthy female adult SD rats were separated in to four groups with sham-operated control with bilateral laprotomy (Sham; n = 10), bilateral overiectomy (OVX; n = 10) group, OVX rats were orallay administrated with 50 mg/kg b...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28628374/effects-of-a-multispecies-probiotic-supplement-on-bone-health-in-osteopenic-postmenopausal-women-a-randomized-double-blind-controlled-trial
#15
Sadegh Jafarnejad, Kurosh Djafarian, Mohammad Reza Fazeli, Mir Saeed Yekaninejad, Abdolrahman Rostamian, Seyed Ali Keshavarz
OBJECTIVE: The development of alternative approaches to prevent and/or treat osteoporosis, as a chronic progressive bone disease, is being considered currently. Among dietary supplements, probiotics may have favorable effects on bone metabolism. Therefore, the aim of this study was to evaluate the effects of a multispecies probiotic supplementation on bone biomarkers and bone density in osteopenic postmenopausal women. METHODS: This randomized double-blind placebo-controlled clinical trial was performed on 50 patients with osteopenia aged 50-72 years...
June 19, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28624935/eldecalcitol-an-active-vitamin-d3-derivative-prevents-trabecular-bone-loss-and-bone-fragility-in-type-i-diabetic-model-rats
#16
Satoshi Takeda, Mitsuru Saito, Sadaoki Sakai, Kenji Yogo, Keishi Marumo, Koichi Endo
Diabetes mellitus is known to adversely affect the bones and be associated with increased fracture risk. We examined whether eldecalcitol (ELD), an active vitamin D3 derivative, could inhibit the diabetic bone loss in streptozotocin-induced type I diabetic rats. ELD (10, 20, or 40 ng/kg), alfacalcidol (ALF; 25, 50, or 100 ng/kg), or vehicle was administered 5 times per week for 12 weeks from 1 week after diabetes induction. Normal control rats received the vehicle. Bone turnover markers, bone mineral density (BMD), and biomechanical strength of the lumbar spine and femur were measured, and bone histomorphometry was performed...
June 17, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28623409/evaluation-of-bone-viability-in-patients-after-girdlestone-arthroplasty-comparison-of-bone-spect-ct-and-mri
#17
G Diederichs, P Hoppe, F Collettini, G Wassilew, B Hamm, W Brenner, M R Makowski
PURPOSE: To test the diagnostic performance of bone SPECT/CT and MRI for the evaluation of bone viability in patients after girdlestone-arthroplasty with histopathology used as gold standard. MATERIALS AND METHODS: In this cross-sectional study, patients after girdlestone-arthroplasty were imaged with single-photon-emission-computed-tomography/computed-tomography (SPECT/CT) bone-scans using 99mTc-DPD. Additionally, 1.5 T MRI was performed with turbo-inversion-recovery-magnitude (TIRM), contrast-enhanced T1-fat sat (FS) and T1-mapping...
September 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28620710/investigation-of-some-disinfection-chemicals-and-water-quality-parameters-in-swimming-pools-in-the-city-center-and-districts-of-canakkale-turkey
#18
Tolga Uysal, Selehattin Yilmaz, Muhammet Turkoglu, Murat Sadikoglu
In this study, the variations in concentrations of some disinfection chemicals such as cyanuric acid (CyA), free chlorine (FC), and residual chlorine (RC), which affect human health, were investigated in the water of swimming pools. In addition, quality parameters such as temperature, pH, and total alkalinity (TA) in 44 swimming pools located in the city center and districts of Canakkale, Turkey, were examined in the summer period. While FC and RC amounts were analyzed using tablet tests with N-N-diethyl phenylenediamine (DPD 1) and potassium iodine (DPD 3) using the colorimetric method in the comparator, TA and CyA levels were measured with a photometric method...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28617491/deciphering-the-dynamics-of-star-molecules-in-shear-flow
#19
Jurij Sablić, Matej Praprotnik, Rafael Delgado-Buscalioni
This work analyses the rotation of star polymers under shear flow, in melts, and in good solvent dilute solution. The latter is modeled by single molecule Brownian hydrodynamics, while melts are modeled using non-equilibrium molecular dynamics in closed (periodic) boxes and in open boundaries. A Dissipative Particle Dynamics (DPD) thermostat introduces pairwise monomer friction in melts at will, in directions normal and tangent to the monomer-monomer vectors. Although tangential friction is seldom modeled, we show that it is essential to control hydrodynamic effects in melts...
July 26, 2017: Soft Matter
https://www.readbyqxmd.com/read/28603180/intratumor-dihydropyrimidine-dehydrogenase-mrna-expression-levels-are-decreased-in-extramammary-paget-s-disease
#20
Yuki Nakamura, Ikko Kajihara, Yamada-Kanazawa Saori, Maeda-Otsuka Saki, Takamitsu Johno, Jun Aoi, Toshikatsu Igata, Shinichi Masuguchi, Satoshi Fukushima, Masatoshi Jinnin, Hironobu Ihn
S-1, a 5-fluorouracil (5-FU)-based anti-cancer agent, is an important drug for treating metastatic extramammary Paget's disease (EMPD). Although intratumor expression levels of 5-FU metabolism enzymes have been studied widely in many solid tumors, no studies have examined on the expression levels of thymidylate synthase (TS), orotate phosphoribosyl-transferase (OPRT) or dihydropyrimidine dehydrogenase (DPD) in skin cancers. The aim of this study was to estimate the intratumoral mRNA expression levels of these genes in EMPD by real time PCR...
June 11, 2017: Drug Discoveries & Therapeutics
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