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https://www.readbyqxmd.com/read/27913881/phase-ii-trial-of-s-1-plus-leucovorin-in-patients-with-advanced-gastric-cancer-and-clinical-prediction-by-s-1-pharmacogenetic-pathway
#1
Ming-Ming He, Dong-Sheng Zhang, Feng Wang, Zi-Xian Wang, Shu-Qiang Yuan, Zhi-Qiang Wang, Hui-Yan Luo, Chao Ren, Miao-Zhen Qiu, Ying Jin, De-Shen Wang, Dong-Liang Chen, Zhao-Lei Zeng, Yu-Hong Li, Yang-Yang He, Yuan-Tao Hao, Pi Guo, Feng-Hua Wang, Yi-Xin Zeng, Rui-Hua Xu
BACKGROUND: The first one-arm phase II trial aimed to evaluate and predict efficacy and safety of S-1 plus oral leucovorin (S-1/LV) as first-line chemotherapy for patients with advanced gastric cancer (AGC), using S-1 pharmacogenetic pathway approach. PATIENTS AND METHODS: A total of 39 patients orally took S-1 at conventional dose and LV simultaneously at a dose of 25 mg twice daily for a week, within a 2-week cycle. The primary endpoint was overall response rate (ORR), while the secondary endpoints were progression-free survival (PFS), time to failure (TTF), overall survival (OS), disease control rate (DCR), and adverse events (AEs)...
December 2, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27910991/structural-fingerprints-of-yielding-mechanisms-in-attractive-colloidal-gels
#2
Arman Boromand, Safa Jamali, João M Maia
Core-Modified Dissipative Particle Dynamics (CM-DPD) with a modified depletion potential and full hydrodynamics description is used to study non-equilibrium properties of colloidal gels with short range attraction potentials at an intermediate volume fraction (ϕ = 0.2) under start-up shear deformation. Full structural and rheological analysis using the stress fabric tensor complemented by bond number and bond distribution evolution under flow reveals that similarly to dilute colloidal gels, flow-induced anisotropy and strain-induced stretching of bonds are present during the first yielding transition...
December 2, 2016: Soft Matter
https://www.readbyqxmd.com/read/27899985/possible-role-of-thymidine-phosphorylase-in-gynecological-tumors-as-an-individualized-treatment-strategy
#3
Masako Shida, Masanori Yasuda, Mariko Fujita, Masaki Miyazawa, Hiroshi Kajiwara, Takeshi Hirasawa, Masae Ikeda, Naruaki Matsui, Toshinari Muramatsu, Mikio Mikami
Thymidine phosphorylase (TP) is structurally similar to platelet-derived endothelial cell growth factor, and it activates 5-fluorouracil (5-FU) prodrugs and also promotes angiogenesis. In the present study, the possibility of using TP expression as a biomarker for 5-FU prodrugs, and the significance of TP as an angiogenic factor, were investigated in patients with gynecological tumors. The subjects enrolled in the study were 188 patients with gynecological tumors who provided informed consent and underwent tumor resection at the Department of Obstetrics and Gynecology of Tokai University Hospital between February 2002 and January 2010...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27894988/experimental-observations-and-dissipative-particle-dynamic-simulations-on-microstructures-of-ph-sensitive-polymer-containing-amorphous-solid-dispersions
#4
Mengchi Sun, Bingyu Li, Yanchun Li, Yangdan Liu, Qi Liu, Hailun Jiang, Zhonggui He, Yongshan Zhao, Jin Sun
Amorphous solid dispersion (ASD) technique is an effective strategy to increase the dissolution rate of poorly soluble drugs. However, it is inherently unstable, and the molecular basis for achieving kinetic stability is not well understood. In this study, lacidipine-Eudragit_E_100 solid dispersions with 20% drug loading were prepared using the solvent evaporation. Dissolution tested showed that ASD had a significantly high rate, which was dependent on the pH of the medium. Based on time-dependent measurement of supersaturation and particle size, inhibition of crystal growth by Eudragit_E_100 differed at pH 1...
November 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27894676/a-multiscale-biomechanical-model-of-platelets-correlating-with-in-vitro-results
#5
Peng Zhang, Li Zhang, Marvin J Slepian, Yuefan Deng, Danny Bluestein
Using dissipative particle dynamics (DPD) combined with coarse grained molecular dynamics (CGMD) approaches, we developed a multiscale deformable platelet model to accurately describe the molecular-scale intra-platelet constituents and biomechanical properties of platelets in blood flow. Our model includes the platelet bilayer membrane, cytoplasm and an elaborate elastic cytoskeleton. Correlating numerical simulations with published in-vitro experiments, we validated the biorheology of the cytoplasm, the elastic response of membrane to external stresses, and the stiffness of the cytoskeleton actin filaments, resulting in an accurate representation of the molecular-level biomechanical microstructures of platelets...
November 11, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27888515/conserving-the-linear-momentum-in-stochastic-dynamics-dissipative-particle-dynamics-as-a-general-strategy-to-achieve-local-thermostatization-in-molecular-dynamics-simulations
#6
Peter P Passler, Thomas S Hofer
Stochastic dynamics is a widely employed strategy to achieve local thermostatization in molecular dynamics simulation studies; however, it suffers from an inherent violation of momentum conservation. Although this short-coming has little impact on structural and short-time dynamic properties, it can be shown that dynamics in the long-time limit such as diffusion is strongly dependent on the respective thermostat setting. Application of the methodically similar dissipative particle dynamics (DPD) provides a simple, effective strategy to ensure the advantages of local, stochastic thermostatization while at the same time the linear momentum of the system remains conserved...
November 26, 2016: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/27883324/hormone-therapy-reduces-bone-resorption-but-not-bone-formation-in-postmenopausal-athletes
#7
Suzy Y Honisett, David Pagliaro, Kathy Tangalakis, Bronwyn Kingwell, Peter Ebeling, Robyn Craven, Juliana Antonopillai, Vasso Apostolopoulos, Lily Stojanovska
INTRODUCTION: Independently, hormone therapy and exercise have well-established protective effects on bone parameters. The combined effects of hormone therapy and exercise, however, are less clear. We, therefore, examined the effects of hormone therapy on bone turnover markers in postmenopausal women undergoing regular high intensity exercise. METHODS: In a randomised, double blind study, postmenopausal athletes competing at Masters level, received either hormone therapy (50 μg transdermal oestradiol, 5 mg MPA, n = 8) or placebo (n = 7) for 20 weeks...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27883319/the-effects-of-hormonal-therapy-and-exercise-on-bone-turnover-in-postmenopausal-women-a-randomised-double-blind-pilot-study
#8
Suzy Y Honisett, Kathy Tangalakis, John Wark, Vasso Apostolopoulos, Lily Stojanovska
INTRODUCTION: Hormone replacement therapy (HRT) and walking were investigated independently and in combination, to determine which treatment provided most effect on bone turnover in postmenopausal women. METHODS: Using a randomised double-blind pilot study, 10 subjects received HRT (transdermal estradiol, 50 μg/day and oral MPA 5 mg/day) and 12 received placebo for 20 weeks. Following a baseline period of treatment, both groups undertook a graduated walking regimen, which increased in intensity, duration and frequency parameters from weeks 8-20...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27875025/adherence-and-barriers-to-hyperinsufflation-in-children-with-congenital-muscular-dystrophy
#9
John E Pascoe, Hemant Sawnani, Oscar H Mayer, Keith McConnell, Joseph M McDonough, Cynthia White, Anne M Rutkowski, Raouf S Amin, Avani C Modi
BACKGROUND: Congenital muscular dystrophy (CMD) is a rare, inherited neuromuscular disease characterized by progressive muscle weakness, thoracic insufficiency, and ultimately respiratory failure. Adherence to respiratory therapies in children with neuromuscular disorders is unknown. This study examined the multimodal assessment of adherence and barriers to 15 min, twice daily hyperinsufflation in children with CMD. Adherence was hypothesized to be greater than 50% and discomfort, embarrassment, and difficulty finding time were hypothesized to be barriers...
November 22, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27873058/prediction-of-the-reverse-micellar-extraction-of-papain-using-dissipative-particle-dynamics-simulation
#10
Mingxiang Lin, Tingting Yu, Junfen Wan, Xuejun Cao
Reverse micellar extraction is a promising technology for large-scale protein purification, but its molecular interaction mechanisms have not been thoroughly characterized. In this study, a dissipative particle dynamics (DPD) molecular simulation method was employed to study the interactions among the surfactant, organic phase, water, and proteins on the mesoscopic scale. This study simulated the self-assembly process of the reverse micelle extraction of papain. The results showed that the papain could be extracted by a CTAB/isooctane/n-hexanol system, which was validated by extraction experiments...
November 21, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27869567/use-of-the-daily-phone-diary-to-study-religiosity-and-mood-convergent-validity
#11
Rhonda D Szczesniak, Yuanshu Zou, Sophia M Dimitriou, Alexandra L Quittner, Daniel H Grossoehme
Studies of religious/spiritual behavior frequently rely on self-reported questionnaire data, which is susceptible to bias. The Daily Phone Diary (DPD) was developed to minimize bias in reporting activities and behavior across a 24-hour period. A cross-sectional study of 126 parents of children with cystic fibrosis was used to establish the validity of the DPD to study religious/spiritual behaviors. Longitudinal models were used to determine the odds of improved mood during religious/spiritual activities. Convergent validity was found...
November 21, 2016: Journal of Health Care Chaplaincy
https://www.readbyqxmd.com/read/27852336/underlying-manifestations-of-developmental-phonological-disorders-in-french-speaking-pre-schoolers
#12
Françoise Brosseau-Lapré, Susan Rvachew
This study examined the psycholinguistic profiles of Quebec French-speaking children with developmental phonological disorders (DPD). The purpose was to determine whether the endophenotypes that have been identified in English-speaking children with DPD are similarly associated with speech impairment in French-speaking children. Seventy-two children with DPD and ten children with normally developing speech, aged four to six years, received a comprehensive assessment battery that included measures at the phenotype level (i...
November 17, 2016: Journal of Child Language
https://www.readbyqxmd.com/read/27845263/osteoclastogenic-capacity-of-peripheral-blood-mononuclear-cells-is-not-different-between-women-with-and-without-osteoporosis
#13
W N H Koek, B C J van der Eerden, R D A M Alves, M van Driel, M Schreuders-Koedam, M C Zillikens, J P T M van Leeuwen
INTRODUCTION: Peripheral Blood Mononuclear Cells (PBMCs) have been extensively used as a culture model to generate osteoclasts in vitro. The aim of this study was to assess the osteoclastogenic potential of PBMCs derived from post-menopausal women with longstanding osteoporosis and compare this with PBMCs from healthy controls. MATERIAL AND METHODS: We selected from the population-based Rotterdam Study 82 participants of which 43 were diagnosed with osteoporosis (T-score below -2...
November 12, 2016: Bone
https://www.readbyqxmd.com/read/27825212/dissipative-particle-dynamics-for-systems-with-high-density-of-charges-implementation-of-electrostatic-interactions
#14
A A Gavrilov, A V Chertovich, E Yu Kramarenko
In this work, we study the question of how to introduce electrostatic interactions in dissipative particle dynamics (DPD) method in order to correctly reproduce the properties of systems with high density of charges, including those with inhomogeneous charge distribution. To this end, we formulate general requirements for the electrostatic force in DPD and propose a new functional form of the force which suits better for satisfying these requirements than the previously used ones. In order to verify the proposed model, we study the problem of a single polyelectrolyte chain collapse and compare the results with molecular dynamics (MD) simulations in which the exact Coulomb force is used...
November 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27822111/danish-palliative-care-database
#15
REVIEW
Mogens Groenvold, Mathilde Adsersen, Maiken Bang Hansen
AIMS: The aim of the Danish Palliative Care Database (DPD) is to monitor, evaluate, and improve the clinical quality of specialized palliative care (SPC) (ie, the activity of hospital-based palliative care teams/departments and hospices) in Denmark. STUDY POPULATION: The study population is all patients in Denmark referred to and/or in contact with SPC after January 1, 2010. MAIN VARIABLES: The main variables in DPD are data about referral for patients admitted and not admitted to SPC, type of the first SPC contact, clinical and sociodemographic factors, multidisciplinary conference, and the patient-reported European Organisation for Research and Treatment of Cancer Quality of Life Questionaire-Core-15-Palliative Care questionnaire, assessing health-related quality of life...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27806564/coarse-grained-models-for-automated-fragmentation-and-parameterization-of-molecular-databases
#16
Johannes G E M Fraaije, Jan van Male, Paul Becherer, Rubèn Serral Gracià
We calibrate coarse-grained interaction potentials suitable for screening large datasets in top-down fashion. Three new algorithms are introduced: (i) automated decomposition of molecules into coarse-grained units (fragmentation), (ii) Coarse-Grained Hypernetted Chain - Reference Interaction Site Model (CG HNC-RISM) as an intermediate proxy for Dissipative Particle Dynamics (DPD), and (iii) an algorithm for calibrating DPD parameters using activity coefficient models. We find that fragment distribution follows Zipf and Heap scaling laws...
November 2, 2016: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/27804073/early-phase-myocardial-uptake-intensity-of-99m-tc-hmdp-vs-99m-tc-dpd-in-patients-with-hereditary-transthyretin-related-cardiac-amyloidosis
#17
Mukedaisi Abulizi, Anne-Ségolène Cottereau, Aziz Guellich, Stéphanie Vandeventer, Arnault Galat, Axel Van Der Gucht, Violaine Plante-Bordeneuve, Jean-Luc Dubois-Randé, Diane Bodez, Jean Rosso, Thibaud Damy, Emmanuel Itti
BACKGROUND: This study sought to compare the intensity of early-phase myocardial uptake of two phosphonate-based radiotracers, (99m)Tc-hydroxymethylene diphosphonate (HMDP) and (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD), in patients with hereditary transthyretin-related cardiac amyloidosis (TTR-CA). METHODS: Six patients with biopsy-proven diagnosis of TTR-CA and characteristic amyloid fibril composition underwent early-phase (99m)Tc-HMDP myocardial scintigraphy as part of their routine workup; they were later assessed by (99m)Tc-DPD scintigraphy after having signed informed written consent...
November 1, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27798895/tumor-5-fu-related-mrna-expression-and-efficacy-of-oral-fluoropyrimidines-in-adjuvant-chemotherapy-of-colorectal-cancer
#18
Keiji Koda, Hideaki Miyauchi, Chihiro Kosugi, Takashi Kaiho, Nobuhiro Takiguchi, Susumu Kobayashi, Takashi Maruyama, Hisahiro Matsubara
BACKGROUND: It has not been elucidated whether the clinical efficacy of oral fluoropyrimidines for adjuvant chemotherapy of colorectal cancer varies with tumor biological characteristics. PATIENTS AND METHODS: A multicenter randomized trial was performed comparing oral tegafur/gimeracil/oteracil (S-1) and uracil-tegafur/ leucovorin (UFT/LV) as adjuvant therapy for stage III colorectal cancer. Postoperative survival was compared based on the 5-FU-related mRNA levels in cancer tissues...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27792725/md-dpd-multiscale-framework-for-predicting-morphology-and-stresses-of-red-blood-cells-in-health-and-disease
#19
Hung-Yu Chang, Xuejin Li, He Li, George Em Karniadakis
Healthy red blood cells (RBCs) have remarkable deformability, squeezing through narrow capillaries as small as 3 microns in diameter without any damage. However, in many hematological disorders the spectrin network and lipid bilayer of diseased RBCs may be significantly altered, leading to impaired functionality including loss of deformability. We employ a two-component whole-cell multiscale model to quantify the biomechanical characteristics of the healthy and diseased RBCs, including Plasmodium falciparum-infected RBCs (Pf-RBCs) and defective RBCs in hereditary disorders, such as spherocytosis and elliptocytosis...
October 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27789270/topical-5-fluorouracil-is-a-novel-targeted-therapy-for-the-keratocystic-odontogenic-tumor
#20
Nicholas J Ledderhof, Marco F Caminiti, Grace Bradley, David K Lam
PURPOSE: The antimetabolite drug, 5-fluorouracil (5-FU), is used in the treatment of various cancers, including basal cell carcinomas (BCCs). The authors hypothesized that keratocystic odontogenic tumors (KOTs) would respond to 5-FU treatment because of their similarities to BCCs in molecular etiopathogenesis. MATERIALS AND METHODS: An ambispective cohort study of the treatment efficacy of topical 5-FU on KOTs was conducted. Independent variables included the topical application of 5% 5-FU or modified Carnoy solution (MC) after enucleation and peripheral ostectomy at the University of Toronto from 2006 through 2014...
September 30, 2016: Journal of Oral and Maxillofacial Surgery
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