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Luqing Wei, Xiao Hu, Yonggui Yuan, Weiguo Liu, Hong Chen
Neuropathology suggests that Parkinson's disease (PD) with depression may involve a progressive degeneration of the nigrostriatal and mesocorticolimbic dopaminergic systems. Previous positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies have shown that dopamine changes in individual brain regions constituting the nigrostriatal and mesocorticolimbic circuits are associated with depression in PD. However, few studies have been conducted on the circuit-level alterations in this disease...
March 9, 2018: Behavioural Brain Research
Hiroto Inoue, Yuto Sato, Shuuhei Shintani, Hiroki Tanabe, Hiromichi Bamba, Yasunobu Komai, Tomoaki Nakamura, Takayuki Imai, Akira Andou
We report the case of a 61-year-old man who experienced severe adverse effects of capecitabine because of dihydropyrimidine dehydrogenase (DPD) deficiency. In 2016, he visited our hospital for adenocarcinoma of the gastroesophageal junction and was prescribed neoadjuvant chemotherapy with capecitabine, cisplatin, and trastuzumab. On day 14 of chemotherapy, he developed severe diarrhea, canker sores, enterocolitis, febrile neutropenia, and thrombocytopenia. He was then urgently hospitalized, and anticancer treatment was stopped...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Wengen Chen, Van-Khue Ton, Vasken Dilsizian
PURPOSE OF REVIEW: The two most common types of cardiac amyloidosis are caused by fibril deposits of immunoglobulin light chains (AL) and transthyretin (TTR), each with distinct prognosis and clinical management. Cardiac amyloidosis is under-recognized among heart failure patients with preserved ejection fraction (HFpEF). Bone-seeking tracers like99m Tc-PYP and99m Tc-DPD have long been used to identify cardiac amyloidosis, and more recently, to differentiate TTR from AL cardiac amyloidosis in symptomatic patients...
March 8, 2018: Current Cardiology Reports
Chufen Yang, Zhaolin Xue, Yinglin Liu, Jiayu Xiao, Jingrui Chen, Lijuan Zhang, Jianwei Guo, Wenjing Lin
To improve the drug release rate in well-controlled manner, a new pH-sensitive triblock amphiphilic copolymer methyl poly(ethylene glycol) ether-b-poly(β-amino esters)-b-poly lactic acid (MPEG-b-PBAE-b-PLA) and its self-assembled micelles were developed for anticancer drug delivery. The average molecular weight and molecular structure of MPEG-b-PBAE-b-PLA were confirmed by gel permeation chromatography (GPC) and1 H NMR. The formation of self-assembled micelles, the microstructures at different pH values, and the distribution of doxorubicin (DOX) were investigated by dissipative particle dynamics (DPD) simulation combined with experimental techniques...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
N O Elander, K Aughton, P Ghaneh, J P Neoptolemos, D H Palmer, T F Cox, F Campbell, E Costello, C M Halloran, J R Mackey, A G Scarfe, J W Valle, A C McDonald, R Carter, N C Tebbutt, D Goldstein, J Shannon, C Dervenis, B Glimelius, M Deakin, R M Charnley, Alan Anthoney, M M Lerch, J Mayerle, A Oláh, M W Büchler, W Greenhalf
BACKGROUND: Dihydropyrimidine dehydrogenase (DPD) tumour expression may provide added value to human equilibrative nucleoside transporter-1 (hENT1) tumour expression in predicting survival following pyrimidine-based adjuvant chemotherapy. METHODS: DPD and hENT1 immunohistochemistry and scoring was completed on tumour cores from 238 patients with pancreatic cancer in the ESPAC-3(v2) trial, randomised to either postoperative gemcitabine or 5-fluorouracil/folinic acid (5FU/FA)...
March 8, 2018: British Journal of Cancer
Ryan L Marson, Yuanding Huang, Ming Huang, Taotao Fu, Ronald G Larson
We find using dissipative particle dynamics (DPD) simulations that a deformable droplet sheared in a narrow microchannel migrates to steady-state position that depends upon the dimensionless particle capillary number , which controls the droplet deformability (with Vmax the centerline velocity, μf the fluid viscosity, Γ the surface tension, R the droplet radius, and H the gap), the droplet (particle) Reynolds number , which controls inertia, where ρ is the fluid density, as well as on the viscosity ratio of the droplet to the suspending fluid κ = μd /μf ...
March 7, 2018: Soft Matter
Eve Piekarski, Renata Chequer, Vincent Algalarrondo, Ludivine Eliahou, Besma Mahida, Jonathan Vigne, David Adams, Michel S Slama, Dominique Le Guludec, Francois Rouzet
PURPOSE: Cardiac involvement in familial transthyretin (TTR) amyloidosis is of major prognostic value, and the development of early-diagnostic tools that could trigger the use of new disease-modifying treatments is crucial. The aim of our study was to compare the respective contributions of99m Tc-diphosphonate scintigraphy (DPD, detecting amyloid deposits) and123 I-MIBG (MIBG, assessing cardiac sympathetic denervation) in patients with genetically proven TTR mutation referred for the assessment of cardiac involvement...
March 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Marie-Anne Loriot, Joseph Ciccolini, Fabienne Thomas, Chantal Barin-Le-Guellec, Bernard Royer, Gérard Milano, Nicolas Picard, Laurent Becquemont, Céline Verstuyft, Céline Narjoz, Antonin Schmitt, Christine Bobin-Dubigeon, Alexandre Harle, Angelo Paci, Vianney Poinsignon, Sylvie Quaranta, Alexandre Evrard, Benjamin Hennart, Franck Broly, Xavier Fonrose, Claire Lafay-Chebassier, Anne-Sophie Wozny, Fadil Masskouri, Jean-Christophe Boyer, Marie-Christine Etienne-Grimaldi
Fluoropyrimidines (FU) are still the most prescribed anticancer drugs for the treatment of solid cancers. However, fluoropyrimidines cause severe toxicities in 10 to 40% of patients and toxic deaths in 0.2 to 0.8% of patients, resulting in a real public health problem. The main origin of FU-related toxicities is a deficiency of dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme of 5-FU catabolism. DPD deficiency may be identified through pharmacogenetics testing including phenotyping (direct or indirect measurement of enzyme activity) or genotyping (detection of inactivating polymorphisms on the DPYD gene)...
February 24, 2018: Bulletin du Cancer
Sachithra Amarin Hettiarachchi, Su-Jin Lee, Youngdeuk Lee, Young-Kyung Kwon, Kae Kyoung Kwon, Sung-Hyun Yang, Eunyoung Jo, Do-Hyung Kang, Chulhong Oh
A gram-negative, rod-shaped, motile, oxidase- and catalase-positive, non-pigmented marine bacterium, designated strain OS-11M-2T , was isolated from a coral sample collected from the Osakura coastal area in Micronesia. Phylogenetic analysis based on 16S ribosomal RNA (rRNA) gene sequences indicated that strain OS-11M-2T is a member of the family Vibrionaceae, its closest neighbors being Photobacterium damselae subsp. piscicida NCIMB 2058T (94.9%), Photobacterium damselae subsp. damselae CIP 102761T (94.75%), Grimontia marina IMCC5001T (94...
February 20, 2018: Current Microbiology
Md Amdadul Huq, Shahina Akter, Sun-Young Lee
A novel bacterial strain MAH-10T was isolated from soil sample of a Chinese cabbage garden, Republic of Korea and was characterized using a polyphasic approach. Cells were Gram-staining negative, rod-shaped, yellowish orange colored, and motile. The strain was aerobic, catalase and oxidase are positive, and optimum growth temperature and pH were 28 °C and 6.5, respectively. Flexirubin-type pigments were found to be present. On the basis of 16S rRNA gene sequence analysis, strain MAH-10T belongs to the genus Flavobacterium and is most closely related to Flavobacterium tyrosinilyticum KCTC 42726T (98...
February 20, 2018: Current Microbiology
Zhiqiang Shen, Huilin Ye, Martin Kröger, Ying Li
The PEGylated liposome, composed of an aqueous core and a fluid state lipid bilayer shell, is one of the few Food and Drug Administration (FDA) approved drug delivery platforms. To prevent the absorption of serum proteins, the surface of a liposome is decorated by hydrophilic and bio-compatible polyethylene glycol (PEG) polymers, which can significantly extend the blood circulation time of liposomes. In this work, with the help of dissipative particle dynamics (DPD) simulations, we explore how the tethered PEG polymers will affect the membrane wrapping process of PEGylated liposomes during endocytosis...
February 20, 2018: Nanoscale
Sophie Becker, Dr Volker Bickert, Kai Reimers, Dr Martin Becker
In order to further clarify if and how much Ozone is generated during HVLD and to identify measures to reduce the impact of Ozone generation on product quality a highly sensitive analytical system [4] was employed to investigate the generation of Ozone at different operational conditions of HVLD integrity testing. The analytical system is based on oxidation of Iodide ions in solution and identification of the Iodine formed by N, N-Diethyl-p-phenylendiamine (DPD) according to DIN 38403 [4].Sensitivity of the system was found suitable to detect Ozone levels as low as 0...
February 14, 2018: PDA Journal of Pharmaceutical Science and Technology
Bart A W Jacobs, Nikol Snoeren, Morsal Samim, Hilde Rosing, Niels de Vries, Maarten J Deenen, Jos H Beijnen, Jan H M Schellens, Miriam Koopman, Richard van Hillegersberg
PURPOSE: The dihydrouracil (DHU):uracil (U) plasma ratio is a promising marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient patients. The objective of this study was to determine the effect of liver resection on the DHU:U plasma ratio in patients with colorectal liver metastases (CRLM). METHODS: An observational study was performed in which DHU:U plasma ratios in patients with CRLM were analyzed prior to and 1 day after liver resection...
February 11, 2018: European Journal of Clinical Pharmacology
Yasuhisa Hasegawa, Mitsuo Goto, Nobuhiro Hanai, Taijiro Ozawa, Hitoshi Hirakawa
The present study aimed to identify significant correlations between gene expression and chemotherapy response to 5-fluorouracil (5-FU)/cisplatin in head and neck squamous cell carcinoma (HNSCC), and to identify patients who would benefit from induction chemotherapy for both organ preservation and survival. A total of 64 patients who underwent radical treatment for HNSCC were enrolled. All patients received induction chemotherapy with 5-FU/cisplatin and tumor responses were evaluated. Pretreatment biopsy specimens from all patients were assayed for mRNA expression of thymidylate synthase, dihydropyrimidine dehydrogenase (DPD), orotate phosphoribosyltransferase, tymidine phosphorylase, glutathione S-transferase-pi, p53, RB Transcriptional Corepressor 1, B-cell lymphoma 2 (Bcl-2), Bcl-xL, E2F Transcription Factor 1, epidermal growth factor receptor, human epidermal growth factor receptor 2, phosphoinositide 3-kinase, phosphatase and tensin homolog, vascular endothelial growth factor (VEGF), cyclooxygenase-2, XPA, DNA Damage Recognition And Repair Factor, excision repair cross-complementing 1 (ERCC1), multidrug resistance gene 1 (MDR1), multidrug resistance-associated protein 1, equilibrative nucleoside transporter 1 and β-tubulin by reverse transcription-quantitative polymerase chain reaction, and the association between the expression levels of these genes and patient response to chemotherapy was determined...
February 2018: Molecular and Clinical Oncology
Takahiro Akiyama, Jun Yasutomi, Kimihiko Kusashio, Masanari Matsumoto, Takeshi Suzuki, Ayako Iida, Namiko Imamura, Arihito Yoshizumi, Rina Harano, Ikuo Udagawa, Masayuki Ohtsuka
We report a case of a 79-year-old man who developed severe therapy-related pancytopenia from tegafur uracil(UFT)and Leucovorin(LV)as adjuvant chemotherapy for ascending colon cancer. Laparoscopic right hemicolectomy resection was performed for the ascending colon cancer. Pathohistological analysis revealed that the ascending colon tumor was moderately differentiated tubular adenocarcinoma(T3, N1, M0, and Stage III a). Postoperative adjuvant chemotherapy with UFT and LV was administered. After 2 courses of chemotherapies, severe thrombocytopenia(Grade 4)and neutropenia(Grade 4)were noted...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Hiroaki Nagano, Shuntaro Obi, Etsuro Hatano, Shuichi Kaneko, Fumihiko Kanai, Masao Omata, Akihito Tsuji, Toshiyuki Itamoto, Kazuhide Yamamoto, Masatoshi Tanaka, Shoji Kubo, Koichi Hirata, Hideji Nakamura, Yoshito Tomimaru, Takeharu Yamanaka, Shinsuke Kojima, Morito Monden
BACKGROUND: No effective therapies for extrahepatic metastases from hepatocellular carcinoma (HCC) have yet been identified. Previous studies suggested a potentially promising anti-tumor effect of combination therapy of S-1, a novel oral dihydropyrimidine dehydrogenase (DPD) inhibitor, and interferon (IFN)-α. The present study aimed to investigate the clinical efficacy of single agent S-1 and S-1/IFN-α for HCC patients with extrahepatic metastases in a randomized, open-label, multicenter trial...
January 27, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Tatiana Matáková, Erika Halašová, Henrieta Škovierová, Anton Dzian, Dušan Dobrota, Mária Škereňová
Dihydropyrimidine dehydrogenase (DPD) acts as the first-step enzyme catabolizing pyrimidines in vivo. DPYD gene mutations interfere with the breakdown of uracil and thymine. Genetic variations of DPYD can cause an enzyme deficiency state, which results in severe toxicity or other adverse side effects such as DNA damage or RNA damage caused by imbalance of the nucleotide pool. Our case-control study investigates the possible association between seven DPYD gene polymophisms (rs1801267, rs72547602, rs1801160, rs3918290, rs1801159, rs1801158, rs1801265) and risk of colorectal cancer (CRC)...
December 2017: General Physiology and Biophysics
Masanori Naito, Shinichiro Chino, Hideki Ushiku, Yatsushi Nishi, Yasushi Kondo, Hidefumi Kubo, Takeshi Kaida, Wataru Yamashita, Yoshihito Takahashi, Masahiko Watanabe
INTRODUCTION: Although chemotherapy is the main treatment for recurrent colorectal cancer, the utility of radiotherapy as a local treatment has been widely reported. We performed chemoradiotherapy with S-1 for cases with recurrence after surgery, and the outcomes are reported herein. MATERIALS AND METHODS: Chemoradiotherapy with S-1 was performed in 4 cases. S-1 was administered for 2 weeks during the irradiation period, and the off period provided was 1 week. RESULTS: X-ray irradiation was performed in 2 cases and proton beam irradiation in the other 2...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Jiexin Yin, Ding Wang, Ying Wu
This paper focuses on the localization methods for multiple sources received by widely separated arrays. The conventional two-step methods extract measurement parameters and then estimate the positions from them. In the contrast to the conventional two-step methods, direct position determination (DPD) localizes transmitters directly from original sensor outputs without estimating intermediate parameters, resulting in higher location accuracy and avoiding the data association. Existing subspace data fusion (SDF)-based DPD developed in the frequency domain is computationally attractive in the presence of multiple transmitters, whereas it does not use special properties of signals...
January 23, 2018: Sensors
Abheepsa Mishra, Kamesh Ayasolla, Vinod Kumar, Xiqian Lan, Himanshu Vashistha, Rukhsana Aslam, Ali Hussain, Sheetal Chowdhary, Shadafarin Marashi Shoshtari, Nitpriya Paliwal, Waldemar Popik, Moin A Saleem, Ashwani Malhotra, Leonard G Meggs, Karl Skorecki, Pravin C Singhal
The loss of podocyte (PD) molecular phenotype is an important feature of diabetic podocytopathy. We hypothesized that high glucose (HG) induces dedifferentiation in differentiated podocytes (DPD) through alterations in APOL1-microRNA (miR) 193a axis. HG-induced DPDs dedifferentiation manifested in the form of down regulation of WT1 and upregulation of PAX2 expression. WT1- silenced DPDs displayed enhanced expression of PAX2. Immunoprecipitation (IP) of DPD cellular lysates with anti-WT1 antibody revealed formation of WT1 repressor complexes containing Polycomb group proteins (PcG), EZH2, Menin, and DNA methyl transferase (DNMT1), whereas, silencing of either WT1 or DNMT1 disrupted this complex with enhanced expression of PAX2...
January 10, 2018: American Journal of Physiology. Renal Physiology
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