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https://www.readbyqxmd.com/read/27891686/implementation-of-a-real-time-reference-and-calibration-grid-platform-for-improved-screening-mapping-in-pap-test-slides
#1
Evangelos Tsiambas, Christos Riziotis
Cervical cancer screening based on the Papanicolaou (Pap) test is a widely applied but not always efficient practice for detecting Human Papillomavirus (HPV) mediated lesions, partially due to a non-systematic and inadequate screening process. Our aim was to introduce an inexpensive easy-to-use direct screening platform for improved detection of abnormal cells indicative of underlying cervical neoplasia as well as persisting HPV infection. By employing a novel, efficient technique of laser-based micromachining, we achieved the fabrication of spatial grids on commercially available coverslips allowing visual segmentation of the slide for efficient screening...
November 27, 2016: Pathology International
https://www.readbyqxmd.com/read/27891400/prevalence-of-human-papilloma-virus-infection-in-young-primiparous-women-during-postpartum-period-study-from-a-tertiary-care-center-in-northern-india
#2
Alpana Garg, Vanita Suri, Raje Nijhawan, Neelam Aggarwal, Ritu Aggarwal, Charu Guleria, Mili Thakur
INTRODUCTION: Assessment of high-risk Human Papilloma Virus (HPV) prevalence is important for monitoring long-term decrease in cervical cancer after implementation of the prophylactic HPV vaccination. AIM: To determine the prevalence of high-risk HPV infection and cytological abnormalities in young primiparous women in the age group of 16-26years. MATERIALS AND METHODS: In this cross-sectional study, 214 primiparous women aged 16-26years were recruited from a public tertiary health care center postpartum clinic between June 2013 and May 2014...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27863182/corpora-amylacea-and-molluscum-contagiosum-on-a-cervical-pap-smear
#3
Kaila Buckley, Zaibo Li
When evaluating a Papanicolaou (Pap) smear, the cytology of the squamous epithelial cells is of utmost importance. This is what cytopathologists use to render a diagnosis, ranging from normal to atypical squamous cells of undetermined significance (ASCUS) to high grade squamous intraepithelial lesions, or even squamous cell carcinoma. However, occasionally the pathologist will run into microscopic noncellular material as in our case, such as corpora amylacea on the slides, or even uncommon viral inclusions such as Molluscum contagiosum (MCV)...
November 8, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27830099/how-colposcopy-misses-invasive-cervical-cancer-a-case-report-from-the-improve-colpo-study
#4
Jeff Livingston, Emmanouil Papagiannakis
Colposcopy with biopsy is pivotal to cervical cancer prevention programs as it is called to identify the precancerous lesions on patients that screen positive. We present a cervical cancer case from IMPROVE-COLPO, a postmarketing, multicenter, two-arm observational study on US community colposcopy that collects outcomes with the adjunctive Dynamic Spectral Imaging (DSI) in its prospective arm. A 45-year-old woman was seen for suffering of heavy periods. She had cytology of Atypical Squamous Cells of Undetermined Significance (ASC-US) and was Human Papillomavirus (HPV) positive...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27826216/the-danish-quality-database-for-cervical-cancer-screening
#5
REVIEW
Carsten Rygaard
AIM OF DATABASE: To monitor and improve the quality of the Danish national cervical cancer screening program, an annual report is published, including nine quality indicators. STUDY POPULATION: The screening target group consisted of 1.5 million Danish women aged 23-64 years, but in the calculation of quality indicators, the dataset varies according to indicators being Danish women, cervical cancer cases, or cytology samples. MAIN VARIABLES: The variables include the number of cytology samples per pathology laboratory, participation rate, percentage of unsatisfactory samples, diagnostic sensitivity and specificity, percentage of samples answered within ≤10 days, percentage of atypical squamous cells of undetermined significance samples in women aged >30 years with human papillomavirus-triage, coverage, percentage of non-normal samples not followed up according to recommendations, number of incident cervical cancers, incidence of cervical cancer in the past 5 years, and upcoming percentage of incident cervical cancers undergoing audit...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27824767/similar-risk-patterns-after-cervical-screening-in-two-large-u-s-populations-implications-for-clinical-guidelines
#6
Julia C Gage, William C Hunt, Mark Schiffman, Hormuzd A Katki, Li A Cheung, Orrin Myers, Jack Cuzick, Nicolas Wentzensen, Walter Kinney, Philip E Castle, Cosette M Wheeler
OBJECTIVE: To compare the risks of histologic high-grade cervical intraepithelial neoplasia (CIN) or worse after different cervical cancer screening test results between two of the largest U.S. clinical practice research data sets. METHODS: The New Mexico Human Papillomavirus (HPV) Pap Registry is a statewide registry representing a diverse population experiencing varied clinical practice delivery. Kaiser Permanente Northern California is a large integrated health care delivery system practicing routine HPV cotesting since 2003...
December 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27821987/a-study-of-pap-smear-in-hiv-positive-females
#7
Apeksha Madan, Sunita Patil, Leena Nakate
BACKGROUND: HIV-positive females are more likely to have abnormal Pap smears than HIV-negative women. These abnormal Pap smears are usually associated with low CD4 cell counts and human papilloma virus infection. MATERIALS AND METHODS: This was a prospective hospital-based study from April 2013 till March 2014. A total of 250 (both symptomatic and asymptomatic) HIV-positive females were examined in Gynaecology OPD at R.C.S.M. G.M.C and C.P.R. Hospital, Kolhapur, and their cervical smears were taken...
December 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27816739/punch-biopsy-guided-by-both-colposcopy-and-hr-hpv-status-is-more-efficient-for-identification-of-immediate-high-grade-squamous-intraepithelial-lesion-or-worse-among-hpv-infected-women-with-atypical-squamous-cells-of-undetermined-significance
#8
Z Ding, Y Li, A Chen, M Song, Y Zhang
OBJECTIVES: To investigate the accuracy of colposcopy for diagnosing high-grade squamous intraepithelial lesion (HSIL) or worse (HSIL+) in human papillomavirus (HPV)-infected patients with atypical squamous cells of undetermined significance (ASCUS) cytology, and determine whether genotyping and viral load quantitation can be useful for detecting immediate HSIL+ risk in these patients. STUDY DESIGN: This study included 620 cases with ASCUS and positive for high-risk (HR)-HPV within 1 month before or after cervical cytology at Qilu Hospital between February 2013 and February 2014...
October 23, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27797253/experience-of-combined-liquid-based-cervical-cytology-and-high-risk-hpv-mrna-for-cervical-cancer-screening-in-thammasat-university-hospital
#9
Teerapat Muangto, Athita Chanthasenanont, Supapen Lertvutivivat, Tongta Nanthakomon, Densak Pongrojpaw, Kornkarn Bhamarapravatana, Komsun Suwannarurk
BACKGROUND: Cervical cancer is the second most common of malignancy found in Thai women. Human papillomavirus (HPV) infection is a major cause. The objective of the present study was to evaluate the prevalence of HPV infection and association with abnormal cervical cytology in Thai women. MATERIALS AND METHODS: This study was conducted at the Gynecologic Clinic, Thammasat University, Pathum Thani, Thailand. A total of 2,144 cases who underwent annual cervical cancer screening by co-testing (liquid based cytology and HPV testing, DNA versus mRNA) during the priod from July 2013 to June 2016 were recruited in this study...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27797243/silent-high-grade-cervical-intraepithelial-neoplasia-in-atypical-smears-from-liquid-based-cervical-cytology-three-years-experience-in-thammasat-university-hospital
#10
Supapen Lertvutivivat, Athita Chanthasenanont, Athita Chanthasenanont, Teerapat Muangto, Tongta Nanthakomon, Densak Pongrojpaw, Kornkarn Bhamarapravatana, Komsun Suwannarurk
PURPOSE: To study the prevalence of CIN2+ diagnosis in women with atypical Papaniculoau (Pap) smears to suggest appropriate management option for Thai health care. MATERIALS AND METHODS: Data from all patients with liquid based cytology with human papillomavirus (HPV) testing between May 2013 - May 2016 were collected from medical records. Women with atypical cervical Pap smears were recruited. Results for age, HPV testing, HPV 16, 18, 45 and other genotypes tested, colposcopic examination and histopathological assessment were all collected...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27788516/the-role-of-cytology-in-the-21st-century-the-integration-of-cells-and-molecules
#11
Christine Bergeron, Magnus von Knebel Doeberitz
OBJECTIVES: Cervical cancer screening test performance has been hampered by either a lack of sensitivity in Pap cytology or a lack of specificity of human papillomavirus (HPV) testing. This is disturbing for patients and a cause of high costs for health care providers. STUDY DESIGN: The identification of p16INK4a as a specific marker for the neoplastic transformation of cervical squamous epithelial cells by HPVs allows the identification of HPV-transformed cells in cytopathology specimens...
October 28, 2016: Acta Cytologica
https://www.readbyqxmd.com/read/27755998/impact-of-variations-in-triage-cytology-interpretation-on%C3%A2-human-papillomavirus-based-cervical-screening-and%C3%A2-implications-for-screening-algorithms
#12
Guglielmo Ronco, Marco Zappa, Silvia Franceschi, Sara Tunesi, Adele Caprioglio, Massimo Confortini, Annarosa Del Mistro, Francesca Carozzi, Nereo Segnan, Manuel Zorzi, Paolo Giorgi-Rossi
BACKGROUND: Women positive to human papillomavirus (HPV+) testing at cervical screening need triage, typically cytology and immediate colposcopy in case of atypical squamous cells of undetermined significance (ASCUS) or worse (ASCUS+) or, in cytology-normal HPV+ women, HPV test repeat after 1 year and colposcopy referral if still HPV+. Our hypothesis was that substantial variations in triage positivity and sensitivity may produce little variation in overall referral to colposcopy and on sensitivity of the entire screening process...
November 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27746423/beneficial-effects-of-human-papillomavirus-vaccine-for-prevention-of-cervical-abnormalities-in-miyagi-japan
#13
Nobuyoshi Ozawa, Kiyoshi Ito, Toru Tase, Hirohito Metoki, Nobuo Yaegashi
Prevention of cervical cancer has been unsuccessful in Japan because of low rates of cancer screening and vaccination. The Vaccine Adverse Review Committee of the Japanese Government investigated 2,475 adverse events and reported 617 (6.9/100,000) severe cases and 176 (2.0/100,000) cases with chronic pain. The proactive recommendation for human papillomavirus (HPV) vaccination has been suspended since June 2013. In this study, we examined vaccination rate and incidence of abnormal cervical cytology in women aged 20 to 24 years attending cancer screening in Miyagi...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27731938/knowledge-of-the-hpv-status-biases-cytotechnologists-interpretation-of-pap-tests-originally-diagnosed-as-negative-for-intraepithelial-lesion-or-malignancy
#14
Erika E Doxtader, Jennifer A Brainard, Dawn Underwood, Deborah J Chute
BACKGROUND: Because of cervical cancer screening recommendations and forthcoming first-line human papillomavirus (HPV) screening, many Papanicolaou (Pap) tests will be performed in patients with known concurrent HPV results. This study was designed to evaluate whether knowledge of the HPV status affects cytotechnologists' interpretation of Pap tests. METHODS: A retrospective search of cervical screening Pap tests with known concurrent HPV results provided 250 ThinPrep Pap tests, which were chosen to reflect an atypical rate similar to the rate of the Cleveland Clinic's normal practice...
October 12, 2016: Cancer
https://www.readbyqxmd.com/read/27714942/management-of-atypical-squamous-cells-of-undetermined-significance-or-low-grade-squamous-intraepithelial-lesions-of-the-uterine-cervix-with-human-papilloma-virus-infection-among-young-women-aged-less-than-25-years
#15
Ki-Jin Ryu, Sanghoon Lee, Kyung-Jin Min, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee
Current ASCCP guidelines recommend repeat cytology 12 months after HPV-positive results in women aged 21-24 years with either atypical squamous cells of undetermined significance (ASCUS) or a low-grade squamous intraepithelial lesion (LSIL). The purpose of this study was to validate an algorithm in such women with ASCUS or LSIL. A multicenter cross-sectional study was carried out at three academic hospitals involving 40,847 Korean women who underwent cervical cancer screening with cytology and HPV testing with or without subsequent colposcopic biopsies between January 2007 and December 2013...
December 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27703293/diagnostic-approach-to-patients-with-atypical-squamous-cells-of-undetermined-significance-cytologic-findings-on-cervix
#16
Mahira Jahic, Elmir Jahic
BACKGROUND: Atypical squamous cells of undetermined significance (ASCUS) is a term that refers to inflammatory, reactive and reparative processes which are atypical and of higher level and insufficient to be classified as cervical intraepithelial lesions (CIN). AIMS: Examine of frequency of HPV infection in ASCUS lesions and regression, stagnation and progression during six-month period. SUBJECTS AND METHODS: Prospective study was conducted over a period of 3 years...
July 27, 2016: Medical Archives
https://www.readbyqxmd.com/read/27685757/hpv-for-cervical-cancer-screening-hpv-focal-complete-round-1-results-of-a-randomized-trial-comparing-hpv-based-primary-screening-to-liquid-based-cytology-for-cervical-cancer
#17
Gina S Ogilvie, Mel Krajden, Dirk van Niekerk, Laurie W Smith, Darrel Cook, Kathy Ceballos, Marette Lee, Laura Gentile, Lovedeep Gondara, Ruth Elwood-Martin, Stuart Peacock, Gavin Stuart, Eduardo L Franco, Andrew J Coldman
: Complete Round 1 data (baseline and 12-month follow-up) for HPV FOCAL, a randomized trial establishing the efficacy of HPV DNA testing with cytology triage as a primary screen for cervical cancer are presented. Women were randomized to one of three arms: Control arm - Baseline liquid-based cytology (LBC) with ASCUS results triaged with HPV testing; Intervention and Safety arms - Baseline HPV with LBC triage for HPV positives. Results are presented for 15,744 women allocated to the HPV (intervention and safety combined) and 9,408 to the control arms...
January 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27673362/anal-squamous-intraepithelial-lesions-and-hpv-among-young-black-men-who-have-sex-with-men
#18
Kristin Keglovitz, Andrew D Richardson, Nicola Lancki, Tim Walsh, John A Schneider
PURPOSE: Limited data are available on anal squamous intraepithelial lesions (ASILs) and anal human papillomavirus (HPV) infection in young, black populations. The purpose of this study was to examine the prevalence of and relationships between ASILs and high-risk HPV infection in a young (<30 years of age), predominately black, men who have sex with men (MSM) population. METHODS: Results of anal cytology and HPV DNA were gathered for 83 individuals. RESULTS: Forty-two percent of individuals (35) had atypical squamous cells of undetermined significance and 33% (27) had low-grade intraepithelial lesion by cytology...
September 27, 2016: LGBT Health
https://www.readbyqxmd.com/read/27671050/-analysis-of-clinical-and-pathological-characteristics-of-high-risk-hpv-negative-carcinoma-of-the-uterine-cervix
#19
Z M Li, L Q Zeng, X H Peng, L Z Mao, X L Sun, Y H Li, X P Luo
Objective: To study the clinical and pathological characteristics of HPV-negative cervical cancer patients. Methods: Retrospective analysis of 785 cervical cancer patients in Guangdong Women and Children Hospital from Jan. 2005 to Oct. 2015. By detecting high- risk HPV infection by flow-through hybridization genechip technique. Results: (1)Among 785 cases of cervical cancer, 71 cases were negative for HPV infection tested by genechip technique, accounting for 9.0%(71/785), and the relative light units/cut off(RLU/CO)ratios of these 71 cases were less than 1 by hybird capture Ⅱ(HC-Ⅱ)methods...
September 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27651644/reproductive-tract-infections-and-premalignant-lesions-of-cervix-evidence-from-women-presenting-at-the-cancer-detection-centre-of-the-indian-cancer-society-delhi-2000-2012
#20
Subhojit Dey, Parika Pahwa, Arti Mishra, Jyotsna Govil, Preet K Dhillon
OBJECTIVES: Burden of cervical cancer (CC) is highest for women in low- and middle-income countries (LMICs). Human papillomavirus (HPV) is implicated as the necessary cause of CC although a number of other factors aid the long process of CC development. One among them is the presence of reproductive tract infections (RTIs). This study investigated the associations between RTIs and CC from India. METHODS: This study utilized secondary data from the Cancer Detection Centre of the ICS, Delhi...
October 2016: Journal of Obstetrics and Gynaecology of India
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