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https://www.readbyqxmd.com/read/29770625/risks-of-cervical-intraepithelial-neoplasia-grade-3-or-invasive-cancers-in-ascus-women-with-different-management-a-population-based-cohort-study
#1
Yi Jou Tai, Yun Yuan Chen, Huang Cheng Hsu, Chun Ju Chiang, San Lin You, Chi An Chen, Wen Fang Cheng
OBJECTIVE: To investigate the progression risk of atypical squamous cells of undetermined significance (ASCUS) with different clinical managements. METHODS: Women with their first diagnosis of ASCUS cytology were retrieved from the national cervical cancer screening database and linked to the national health insurance research database to identify the management of these women. The incidences of developing cervical intraepithelial neoplasia grade 3 and invasive cervical cancer (CIN3+) were calculated, and the hazard ratios (HRs) were estimated using a Cox proportional hazards model...
March 20, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29747341/-prevalence-of-high-risk-hpv-and-its-distribution-in-cervical-precancerous-lesions-among-35-64-years-old-women-who-received-cervical-cancer-screening-in-beijing
#2
J Shen, L L Gao, Y Zhang, L L Han, J D Wang
Objective: To study the prevalence of high-risk HPV (HR HPV) in women who accepted cervical cancer screening in Beijing and its distribution in cervical precancerous lesions. Methods: From January 2014 to March 2015, all women aged 35-64 years old and received free screening in institutions of cervical cancer in Beijing were recruited. Stratified cluster random sampling method was used in selecting 31 091 women for gynecological examination and genotyping of HR-HPV. Those positive for HR-HPV (except for HPV 16/18) were examined for cervical cell...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29747338/-role-of-hpv-viral-loads-in-random-biopsy-under-normal-colposcopy
#3
X Q Xu, L Zhang, S Y Hu, Remila Rezhake, X L Zhao, F Chen, X Zhang, Q J Pan, Y L Qiao, F H Zhao
Objective: To explore the role of HPV viral loads in random biopsy under normal colposcopy. Methods: 908 atypical squamous cells of undetermined significance (ASC-US) and HPV positive women, recruited in cluster sampling in 9 provinces including 5 urban areas and 9 rural areas in China from 1999 to 2008 and meeting the inclusion and exclusion criteria were included in this analysis. According to relative light units/cutoff (RLU/CO) value, subjects were stratified as low (286 cases), intermediate (311 cases) and high (311 cases) viral load groups...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29736316/hpv16-viral-load-and-physical-state-measurement-as-a-potential-immediate-triage-strategy-for-hr-hpv-infected-women-a-study-in-644-women-with-single-hpv16-infections
#4
Anna Manawapat-Klopfer, Lisa Wang, Juliane Haedicke-Jarboui, Frank Stubenrauch, Christian Munk, Louise T Thomsen, Peter Martus, Susanne K Kjaer, Thomas Iftner
High genome copy number (viral load) of human papillomavirus (HPV) is being discussed as a risk factor for high-grade cervical lesions. However, conflicting data about the integration status or viral load of the virus as risk factors for prevalent high-grade squamous intraepithelial lesions (HSIL) are found in the literature. To investigate whether viral load and/or integration status are indicative for prevalent ASCUS/LSIL or HSIL, we determined the HPV16 viral load and the physical state of the genome in 644 women with single HPV16 infections stratified by their cytology results from a large Danish population-based cohort consisting of 40,399 women...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29728850/liquid-based-cytology-do-ancillary-techniques-enhance-detection-of-epithelial-abnormalities
#5
Sridhar Mishra, Nuzhat Husain, Namrata P Awasthi, Yashodhara Pradeep, Roohi Roohi, Sarita Saxena
PURPOSE: Cervical cancer is the fourth most common cancer in women worldwide with very high incidence in India. Liquid-based cytology (LBC) provides the use of ancillary techniques in addition to a good morphology and detection of cytologic abnormalities. The current study was designed to assess the diagnostics of P16INK4a immunoexpression, p16 promoter hypermethylation, human papilloma virus (HPV), and DNA ploidy in LBC samples with cervical precancer and cancer. METHODS: A series of LBC samples categorised by Bethesda system including 22 atypical squamous cells of undetermined significance (ASC-US), 21 low-grade squamous intraepithelial lesion (LSIL), 41 high-grade squamous intraepithelial lesion (HSIL), 54 squamous cell carcinoma (SCC), and 26 controls with normal cytology were included...
May 4, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29722175/lack-of-transformation-zone-in-cervical-pap-tests-should-it-be-a-concern-a-quality-assurance-initiative
#6
Evelyn Carolina Polanco Jacome, Jennifer Maerki, Karen Chau, Meredith Akerman, Sujata Sajjan, Melissa Klein, Cecilia Gimenez, Alice Laser, Kasturi Das
BACKGROUND: Bethesda guidelines do not require presence of transformation zone (TZ) for a cervical Pap test to be deemed adequate. However, clinicians are concerned with specimens that are reported to lack TZ. METHODS: We analyzed 566 ThinPrep cases reported as negative for intraepithelial lesion or malignancy (NILM) with no cervical abnormality detected in previous 4 years (2007-2011). These cases were divided into two cohorts; those with TZ (ETZ) and those without TZ (NTZ)...
May 2, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29718393/risk-of-hpv-16-18-infections-and-associated-cervical-abnormalities-in-women-seropositive-for-naturally-acquired-antibodies-pooled-analysis-based-on-control-arms-of-two-large-clinical-trials
#7
Mahboobeh Safaeian, Xavier Castellsagué, Allan Hildesheim, Sholom Wacholder, Mark H Schiffman, Marie-Cécile Bozonnat, Laurence Baril, Dominique Rosillon
Background: Studies on the role of antibodies produced after infection with human papillomavirus 18 (HPV-18) and subsequent protection from HPV-18 infection have been conflicting, mainly due to inadequate sample size. Methods: We pooled data from the control arms of the Costa Rica Vaccine Trial and the PATRICIA trial. Using Poisson regression we compared the risk of newly detected 1-time HPV-18 infection, HPV-18 1-year persistent infection (12MPI), and HPV-18-associated atypical squamous cells of undetermined significance or greater (ASC-US+) lesions between HPV-18 seropositive and seronegative women...
April 30, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29716521/a-phylogenetic-analysis-of-the-primnoidae-anthozoa-octocorallia-calcaxonia-with-analyses-of-character-evolution-and-a-key-to-the-genera-and-subgenera
#8
Stephen D Cairns, Herman H Wirshing
BACKGROUND: Previous phylogenetic analyses of primnoid octocorals utilizing morphological or molecular data have each recovered evolutionary relationships among genera that are largely incongruent with each other, with some exceptions. In an effort to reconcile molecular-based phylogenies with morphological characters, phylogenetic reconstructions were performed with 33 of 43 primnoid genera using four loci (mtMutS, COI, 28S and 18S), and ancestral state reconstructions were performed using 9 taxonomically relevant characters...
May 2, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29707775/impact-of-hpv-vaccination-on-outcome-of-cervical-cytology-screening-in-denmark-a-register-based-cohort-study
#9
Lise Holst Thamsborg, George Napolitano, Lise Grupe Larsen, Elsebeth Lynge
4vHPV-vaccination has been tested in randomized controlled trials under almost ideal conditions, and studies of real-life use have compared outcome between vaccinated and unvaccinated women from the same birth cohort and mostly before screening age. Here we present the first - to our knowledge - evaluation of the impact of the 4vHPV-vaccination in real-life without selection bias in the reported data. The study has been carried out by comparing the results after first cervical screening between an HPV-vaccinated and an unvaccinated birth cohort, consisting of women born in Denmark in 1993 and 1983, respectively...
April 29, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29707656/cervical-human-papillomavirus-genotypes-in-hiv-infected-women-a-cross-sectional-analysis-of-the-valhidate-study
#10
G Orlando, S Bianchi, M M Fasolo, F Mazza, E R Frati, G Rizzardini, A Matteelli, N Zanchetta, A Amendola, E Tanzi
Introduction: Primary-prevention by prophylactic vaccination against HPV-related cancers and HPV-based screening programs are based on HPV-type distribution in immunocompetent individuals. HIV-infected women are at high risk of invasive HPV-disease sustained by a broader range of HPV-types and have higher multi-type infection rates than immunocompetent hosts. Methods: This is a cross-sectional analysis of High Risk HPV (HR HPV) type distribution in 805 HIV+ women (HIW) compared with a control group of 1402 immunocompetent HIV- women (SPW) enrolled in the VALHIDATE study in order to define HPV type-specific distribution according to cytology...
December 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/29694716/anal-cytological-lesions-and-hpv-infection-in-individuals-at-increased-risk-for-anal-cancer
#11
Maria Gabriella Donà, Maria Benevolo, Alessandra Latini, Francesca Rollo, Manuela Colafigli, Mirko Frasca, Mauro Zaccarelli, Amalia Giglio, Domenico Moretto, Edoardo Pescarmona, Antonio Cristaudo, Massimo Giuliani
BACKGROUND: Anal cytology may be useful for evaluating lesions associated with human papillomavirus (HPV) in individuals at increased risk for anal cancer. METHODS: Liquid-based cytology was used to assess anal cytological lesions among human immunodeficiency virus (HIV)-infected and HIV-uninfected men who have sex with men (MSM). The Linear Array HPV genotyping test was used for HPV detection. RESULTS: This cross-sectional study included 1021 MSM, of whom 388 were HIV-infected (38...
April 25, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29690666/-roles-of-hpv-detection-in-28-923-patients-with-atypical-squamous-cells-of-undetermined-significance-analysis-of-104-studies-from-china
#12
Z N Wu, Z Su, W Chen, Y L Qiao
Objective: To investigate the human papillomavirus (HPV) positive rate and its usefulness in predicting CIN2+ in women with atypical squamous cells of undetermined significance (ASC-US) cervical cytology. Methods: A pooled analysis was conducted using published data of hospital classification, HPV positive rate and histopathologic diagnosis in ASC-US population during 2005 to 2017 from 104 studies which enrolled 28 923 ASC-US samples. Results: The overall HPV positive rate was 52.09% (range from 12.06% to 88...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29664054/limited-role-of-promoter-methylation-of-mgmt-and-c13orf18-in-triage-of-low-grade-squamous-intraepithelial-lesion
#13
Lu-Lu Sun, Yuan Liu, Xiao Sun, Lei Pan, Dan Wu, Yu-Dong Wang
Background: Promoter methylation of MGMT and C13ORF18 has been confirmed as a potential biomarker for early diagnosis of cervical cancer. The aim of this study was to evaluate the performance of MGMT and C13ORF18 promoter methylation for triage of cytology screening samples and explore the potential mechanism. Methods: Methylation-sensitive high-resolution melting was used to detect promoter methylation of MGMT and C13ORF18 in 124 cervical samples. High-risk human papillomavirus (HR-HPV) was detected by the Digene Hybrid Capture 2® ...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29663363/cervical-cancer-risk-in-hpv-positive-women-after-a-negative-fam19a4-mir124-2-methylation-test-a-post-hoc-analysis-in-the-pobascam-trial-with-14-year-follow-up
#14
Lise M A De Strooper, Johannes Berkhof, Renske D M Steenbergen, Birgit I Lissenberg-Witte, Peter J F Snijders, Chris J L M Meijer, Daniëlle A M Heideman
DNA methylation analysis of cervical scrapes using FAM19A4 and mir124-2 genes has shown a good clinical performance in detecting cervical cancer and advanced CIN lesions in need of treatment in HPV-positive women. To date, longitudinal data on the cancer risk of methylation test-negative women are lacking. In this study, we assessed the longitudinal outcome of FAM19A4/mir124-2 methylation analysis in an HPV-positive screening cohort with 14 years of follow-up. Archived HPV-positive cervical scrapes of 1040 women (age 29-61 years), who were enrolled in the POBASCAM screening trial (ISRCTN20781131) were tested for FAM19A4/mir124-2 methylation...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29655523/the-clinical-value-of-hpv-e6-e7-and-stat3-mrna-detection-in-cervical-cancer-screening
#15
Yibing Fan, Zongji Shen
OBJECTIVE: To explore the value of human papillomavirus (HPV) E6/E7 and signal transducer and activator of transcription 3 (STAT3) mRNA detection in the screening of cervical lesions. METHODS: 192 patients with abnormal ThinPrep cytology test (TCT) results and/or high-risk HPV infection were screened to identify possible cervical lesions in cases. Diagnoses were confirmed by histopathology. Fluorescence in situ hybridization (FISH) was performed to detect and qualify the mRNAs of HPV E6/E7, STAT3, and Survivin in cervical exfoliated cells...
February 11, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29652190/anal-cytology-institutional-statistics-correlation-with-histology-and-development-of-multidisciplinary-screening-program-with-review-of-the-current-literature
#16
Elizabeth G Morency, Tracey Harbert, Nazneen Fatima, Julia Samolcyzk, Kruti P Maniar, Ritu Nayar
CONTEXT: - The incidence of anal cancer in the United States is on the rise in high-risk populations. The anal Papanicolaou test (APT) is advocated as a screening tool, in addition to digital rectal examination and high-resolution anoscopy. OBJECTIVE: - To review our experience and the current literature to create, in cooperation with clinicians, a standardized screening and treatment algorithm given our large volume of APTs. DATA SOURCES: - All APTs collected between January 2013 and June 2015 were reviewed and correlated with follow-up/concurrent biopsy diagnoses, and clinical and social history...
April 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29607650/factors-associated-with-high-grade-anal-intraepithelial-lesion-in-hiv-positive-men-in-a-southern-u-s-city
#17
Melanie Ann Frank, Cecile Lahiri, Minh Ly Nguyen, C Christina Mehta, Marina Mosunjac, Lisa Flowers
The incidence of anal cancer is increased in HIV-infected patients compared to the general population. Risk factors associated with the anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), have not been extensively studied in an urban black population with late stage HIV disease. We performed a retrospective chart review of HIV infected men at the Grady Ponce de Leon Center HIV Clinic in Atlanta, Georgia referred for high resolution anoscopy (HRA), a procedure where anal tissue is examined under magnification and abnormal areas are biopsied...
April 1, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29602377/-the-spanish-society-of-cytology-quality-control-program-of-gynecological-cytology
#18
Francesc Alameda, Sonsoles Aso, Inmaculada Catalina, M Dolores Comes, M Carmen Gomez Mateo, Rosario Granados, Belén Lloveras, Rosa Oncins, Marta Rezola Bajineta, Francesc Treserra
INTRODUCTION: In Spain, the guidelines for cervical cancer screening include a recommendation to enroll in external quality control programs. The Spanish Society of Cytology (SEC) has initiated its own quality control program of gynecological cytology (QCPGC). AIM: To describe and discuss the results of the second round of SEĆs QCPGC. MATERIAL AND METHOD: The cases are selected by a group of expert cytologists. The cases with an agreement of 75% of four cytopathologists were used...
April 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29597202/impact-of-implementing-100-rapid-review-as-a-quality-control-tool-in-cervical-cytology
#19
Juliana Cristina Magalhães, Cinara Zago Silveira Ázara, Sulene Brito do Nascimento Tavares, Edna Joana Claudio Manrique, Rita Goreti Amaral
OBJECTIVE: We aimed to evaluate the impact of implementing 100% rapid review (100% RR) as a quality control tool in cervical smear cytology. DESIGN: A cross-sectional study was conducted in which cytology findings, false-negative results, and quality indicators were evaluated. The variables were analyzed in 2004, the year in which 100% RR was implemented, and again in 2013, i.e., 10 years on. RESULTS: Detection of atypical squamous cells of undetermined significance (ASC-US) increased from 0...
2018: Acta Cytologica
https://www.readbyqxmd.com/read/29593938/oropharynx-hpv-status-and-its-relation-to-hiv-infection
#20
Leonora Maciel de Souza Vianna, Fabiana Pirani Carneiro, Rivadavio Amorim, Eliete Neves da Silva Guerra, Florêncio Figueiredo Cavalcanti Neto, Valdenize Tiziani, Andrea Barretto Motoyama, Anamélia Lorenzetti Bocca
Background: The number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx HPV infection in these patients is not clear. The aim of the present study was to detect HPV infection, and clinical and cytological changes in the oropharynx of HIV-positive patients. Methods: Samples collected from the oropharynx of 100 HIV-positive patients were subjected to hybrid capture (HC), conventional and liquid-based cytology...
2018: PeerJ
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