Jill K Jones, Hengshan Zhang, Anne-Marie Lyne, Florence M G Cavalli, Wafa E Hassen, Kevin Stevenson, Reb Kornahrens, Yuanfan Yang, Sean Li, Samuel Dell, Zachary J Reitman, James E Herndon, Jacob Hoj, Ann Marie Pendergast, Eric M Thompson
BACKGROUND: Medulloblastoma is the most common malignant pediatric brain tumor, and leptomeningeal dissemination (LMD) of medulloblastoma both portends a poorer prognosis at diagnosis and is incurable at recurrence. The biological mechanisms underlying LMD are unclear. The Abelson (ABL) tyrosine kinase family members, ABL1 and ABL2, have been implicated in cancer cell migration, invasion, adhesion, metastasis, and chemotherapy resistance, and are upstream mediators of the oncogene c-MYC in fibroblasts and lung cancer cells...
2023: Neuro-oncology advances