keyword
MENU ▼
Read by QxMD icon Read
search

Vitronectin

keyword
https://www.readbyqxmd.com/read/29222114/blood-vitronectin-is-a-major-activator-of-lif-and-il-6-in-the-brain-through-integrin-fak-and-upar-signaling
#1
M P Keasey, C Jia, L F Pimentel, R S Sante, C Lovins, T Hagg
We defined how blood-derived vitronectin (VTN) rapidly and potently activates leukemia inhibitory factor (LIF) and pro-inflammatory interleukin 6 (IL-6) in vitro and after vascular injury in the brain. VTN (not fibrinogen, fibronectin, laminin-111, collagen-I) robustly increased LIF and IL-6 within 4 hr in C6-astroglioma cells, while VTN-/- mouse plasma was less effective than wildtype. LIF and IL-6 were induced by intracerebral injection of rhVTN in mice, but less by intracerebral hemorrhage in VTN-/- than wildtype littermates...
December 8, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29215086/genetic-predisposition-to-infection-in-a-case-of-atypical-hemolytic-uremic-syndrome
#2
Lambertus van den Heuvel, Kristian Riesbeck, Omaima El Tahir, Valentina Gracchi, Mariann Kremlitzka, Servaas A Morré, A Marceline van Furth, Birendra Singh, Marcin Okrój, Nicole van de Kar, Anna M Blom, Elena Volokhina
Most cases of hemolytic uremic syndrome (HUS) are caused by infection with enterohemorrhagic Escherichia coli (EHEC). Genetic defects causing uncontrolled complement activation are associated with the more severe atypical HUS (aHUS). Non-EHEC infections can trigger the disease, however, complement defects predisposing to such infections have not yet been studied. We describe a 2-month-old patient infected with different Gram-negative bacterial species resulting in aHUS. Serum analysis revealed slow complement activation kinetics...
November 13, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29205553/vitronectin-vn-glycosylation-patterned-by-lectin-affinity-assays-a-potent-glycoproteomic-tool-to-discriminate-plasma-vn-from-cancer-ascites-vn
#3
H Benachour, J Leroy-Dudal, R Agniel, J Wilson, M Briand, F Carreiras, O Gallet
Changes in glycosylation have been associated with human cancer, but their complexity poses an analytical challenge. Ovarian cancer is a major cause of death in women because of an often late diagnosis. At least one-third of patients presents ascites fluid at diagnosis, and almost all have ascites at recurrence. Vitronectin (Vn) is a multifunctional glycoprotein that is suggested to be implicated in ovarian cancer metastasis and is found within ascites. The present study evaluated the potential of using lectin affinity for characterizing the glycosylation pattern of Vn...
December 4, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29180873/in-vitro-study-on-anti-cancer-properties-of-genistein-in-tongue-cancer
#4
Fatima Ardito, Mario R Pellegrino, Donatella Perrone, Giuseppe Troiano, Armando Cocco, Lorenzo Lo Muzio
Purpose: Tongue cancer is an extremely aggressive disease and is characterized by a poor prognosis. It is a complex disease to treat and current therapies have produced mediocre results with many side effects. Some facts suggest that natural essences can support traditional cancer therapy by carrying out a synergistic function with chemotherapy. Therefore, we evaluated the antitumor effects of genistein on tongue carcinoma cells. Methods: Genistein 20, 50 and 100 µM were used for 24, 48 and 72 hours on 3 tongue carcinoma cell lines...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29163796/plasminogen-activator-inhibitor-1-is-an-independent-prognostic-factor-of-ovarian-cancer-and-imd-4482-a-novel-plasminogen-activator-inhibitor-1-inhibitor-inhibits-ovarian-cancer-peritoneal-dissemination
#5
Erika Nakatsuka, Kenjiro Sawada, Koji Nakamura, Akihito Yoshimura, Yasuto Kinose, Michiko Kodama, Kae Hashimoto, Seiji Mabuchi, Hiroshi Makino, Eiichi Morii, Yoichi Yamaguchi, Takeshi Yanase, Akiko Itai, Ken-Ichirou Morishige, Tadashi Kimura
In the present study, the therapeutic potential of targeting plasminogen activator inhibitor-1 (PAI-1) in ovarian cancer was tested. Tissues samples from 154 cases of ovarian carcinoma were immunostained with anti-PAI-1 antibody, and the prognostic value was analyzed. Among the samples, 67% (104/154) showed strong PAI-1 expression; this was significantly associated with poor prognosis (progression-free survival: 20 vs. 31 months, P = 0.0033). In particular, among patients with stage II-IV serous adenocarcinoma, PAI-1 expression was an independent prognostic factor...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152665/effects-of-wd%C3%A2-3-on-tumor-growth-and-the-expression-of-integrin-%C3%AE-v%C3%AE-3-and-erk1-2-in-mice-bearing-human-gastric-cancer-using-the-18f%C3%A2-rgd-pet-ct-imaging-system
#6
Chunhui Jin, Bao-Nan Zhang, Zhipeng Wei, Bo Ma, Qi Pan, Pingping Hu
Activation of the vitronectin receptor αvβ3 and the phosphorylation of extracellular signal‑regulated kinase (ERK)1/2 are critical events during tumor development and progression. The aim of the present study was to investigate the effects of WD‑3, a formula used in traditional Chinese medicine, on integrin αvβ3 and ERK1/2 expression in vivo using a nude mouse‑human gastric cancer xenograft model combined with non‑invasive, real‑time 18F‑Arg‑Gly‑Asp (RGD) positron emission tomography (PET)/computerized tomography (CT) imaging methods...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29149422/interrelationships-among-hydrogen-permeation-physiochemical-properties-and-early-adsorption-abilities-of-titanium
#7
Fang Jia, Lei Zhou, Wangxi Wu
This study aimed to investigate if the titanium samples with low hydrogen permeation which treated with a novel etching combination: phosphoric acid and sodium fluoride could influence the surface physiochemical properties and early adsorption ability. Titanium samples were treated with three different concentrations of the new formula, as groups A, B and C, and treated with the traditional etching formula, as group T. Zeta potential, contact angle, X-ray photoelectron spectroscopy (XPS) and fibronectin (FN)/vitronectin (VN) adsorption of Sprague-Dawley (SD) rat tibial osteotomies in the initial 30min and MG-63 adsorption in the initial 24 h were detected...
November 17, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29142486/vitronectin-and-urokinase-type-plasminogen-activator-gene-expression-levels-are-increased-in-patients-with-coronary-artery-in-stent-restenosis
#8
S M Shafiee, F Noorabad-Ghahroodi, A Amirfarhangi, S R Hosseini-Fard, Z Sharifi, M Najafi
Neointimal hyperplasia is known as a main factor contributing to in-stent restenosis (ISR). Monocytes may play a central role in vessel restenosis process after stent implantation. The aim of this study was to investigate the relationships between the urokinase-type plasminogen activator (PLAU) and vitronectin (Vtn) gene expression levels in peripheral blood mononuclear cell samples isolated from whole blood of 66 patients undergoing coronary artery angiography (22 controls, stenosis < 0.05%; 22 with stent no-restenosis and stenosis < 70%; and 22 with ISR and stenosis > 70%)...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29123267/bpifb1-lplunc1-inhibits-migration-and-invasion-of-nasopharyngeal-carcinoma-by-interacting-with-vtn-and-vim
#9
Fang Wei, Yingfen Wu, Le Tang, Yi He, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Qianjin Liao, Wenling Zhang, Ming Zhou, Bo Xiang, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
BACKGROUND: Bactericidal/Permeability-increasing-fold-containing family B member 1 (BPIFB1, previously termed LPLUNC1) is highly expressed in the nasopharynx, significantly downregulated in nasopharyngeal carcinoma (NPC), and associated with prognosis in NPC patients. Because metastasis represents the primary cause of NPC-related death, we explored the role of BPIFB1 in NPC migration and invasion. METHODS: The role of BPIFB1 in NPC metastasis was investigated in vitro and in vivo...
November 9, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29107384/binding-of-human-complement-c1-sterase-inhibitor-to-leptospira-spp
#10
Leandro Carvalho Dantas Breda, Silvio Arruda Vasconcellos, Dewton de Moraes Vasconcelos, Lourdes Isaac
Leptospirosis is an important zoonosis of global importance caused by bacteria Leptospira spp. Pathogenic Leptospira is resistant to Complement System killing while non-pathogenic Leptospira is rapidly killed by exposure to normal human serum (NHS). Pathogenic Leptospira interact with Complement Regulators such as Factor H, C4b binding protein and Vitronectin avoiding Complement activation and killing by Alternative and Classical Pathways. One important regulator is C1-inhibitor (C1INH) that interacts with C1s or MASPs controlling the cleavage of C4 and C2 molecules, thereby inhibiting the activation of the Classical and Lectin Pathways...
October 13, 2017: Immunobiology
https://www.readbyqxmd.com/read/29097183/vangl2-interacts-with-integrin-%C3%AE-v-to-regulate-matrix-metalloproteinase-activity-and-cell-adhesion-to-the-extracellular-matrix
#11
Tammy N Jessen, Jason R Jessen
Planar cell polarity (PCP) proteins are implicated in a variety of morphogenetic processes including embryonic cell migration and potentially cancer progression. During zebrafish gastrulation, the transmembrane protein Vang-like 2 (VANGL2) is required for PCP and directed cell migration. These cell behaviors occur in the context of a fibrillar extracellular matrix (ECM). While it is thought that interactions with the ECM regulate cell migration, it is unclear how PCP proteins such as VANGL2 influence these events...
October 26, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29080870/-the-range-and-potential-contribution-of-irreversibly-adsorbed-proteins-on-the-surface-of-artificial-implants
#12
J V Ponomareva, L V Limareva, M N Milyakova
Protein adsorption is the first stage of the interaction between prosthetic materials with tissues of the body. They undergo conformational changes depending on the chemical composition and the nanotopography surface. Adsorbed proteins induce adhesion and alter the functional state of migrating cells. Plasma samples from patients were incubated with such matrices as titanium, polypropylene or polyester with fluoropolymer coating meshes. Bound peptides were analyzed by electrophoresis. Qualitative analysis of the peptides extracted from the gel was performed by chromatography-mass spectrometry...
October 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29044715/bayesian-genome-wide-association-analysis-for-body-weight-in-farmed-atlantic-salmon-salmo-salar-l
#13
G M Yoshida, J P Lhorente, R Carvalheiro, J M Yáñez
We performed a genome-wide association study to detect markers associated with growth traits in Atlantic salmon. The analyzed traits included body weight at tagging (BWT) and body weight at 25 months (BW25M). Genotypes of 4662 animals were imputed from the 50K SNP chip to the 200K SNP chip using fimpute software. The markers were simultaneously modeled using Bayes C to identify genomic regions associated with the traits. We identified windows explaining a maximum of 3.71% and 3.61% of the genetic variance for BWT and BW25M respectively...
October 17, 2017: Animal Genetics
https://www.readbyqxmd.com/read/29028290/plasminogen-activator-inhibitor-1-regulates-the-vascular-expression-of-vitronectin
#14
M Luo, Y Ji, Y Luo, R Li, W P Fay, J Wu
Essentials Vitronectin (VN) is produced by smooth muscle cells (SMCs) and promotes neointima formation. We studied the regulation of vascular VN expression by plasminogen activator inhibitor-1 (PAI-1). PAI-1 stimulates VN gene expression in SMCs by binding LDL receptor-related protein 1. Stimulation of VN gene expression may be a mechanism by which PAI-1 controls vascular remodeling. SUMMARY: Background Increased expression of vitronectin (VN) by smooth muscle cells (SMCs) promotes neointima formation after vascular injury, and may contribute to chronic vascular diseases, such as atherosclerosis...
October 13, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28956830/platelet-integrins-in-tumor-metastasis-do-they-represent-a-therapeutic-target
#15
REVIEW
Marion Lavergne, Emily Janus-Bell, Mathieu Schaff, Christian Gachet, Pierre H Mangin
Platelets are small anucleated cell fragments that ensure the arrest of bleeding after a vessel wall injury. They are also involved in non-hemostatic function such as development, immunity, inflammation, and in the hematogeneous phase of metastasis. While the role of platelets in tumor metastasis has been recognized for 60 years, the molecular mechanism underlying this process remains largely unclear. Platelets physically and functionally interact with various tumor cells through surface receptors including integrins...
September 28, 2017: Cancers
https://www.readbyqxmd.com/read/28955745/bioengineered-bruch-s-like-extracellular-matrix-promotes-retinal-pigment-epithelial-differentiation
#16
Samuel McLenachan, Erwei Hao, Dan Zhang, Ling Zhang, Michael Edel, Fred Chen
In the eye, the retinal pigment epithelium (RPE) adheres to a complex protein matrix known as Bruch's membrane (BrM). The aim of this study was to provide enriched conditions for RPE cell culture through the production of a BrM-like matrix. Our hypothesis was that a human RPE cell line would deposit an extracellular matrix (ECM) resembling BrM. The composition and structure of ECM deposited by ARPE19 cells (ARPE19-ECM) was characterized. To produce ARPE19-ECM, ARPE19 cells were cultured in the presence dextran sulphate...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28941021/immobilization-of-vitronectin-binding-heparan-sulfates-onto-surfaces-to-support-human-pluripotent-stem-cells
#17
Lynn Yap, Sadasivam Murali, Gajadhar Bhakta, Drew M Titmarsh, Allen Kuan-Liang Chen, Lyn Chiin Sim, Muriel Bardor, Yu Ming Lim, James C H Goh, Steve K W Oh, Andre B H Choo, Andre J van Wijnen, David E Robinson, Jason D Whittle, William R Birch, Robert D Short, Victor Nurcombe, Simon M Cool
Functionalizing medical devices with polypeptides to enhance their performance has become important for improved clinical success. The extracellular matrix (ECM) adhesion protein vitronectin (VN) is an effective coating, although the chemistry used to attach VN often reduces its bioactivity. In vivo, VN binds the ECM in a sequence-dependent manner with heparan sulfate (HS) glycosaminoglycans. We reasoned therefore that sequence-based affinity chromatography could be used to isolate a VN-binding HS fraction (HS9) for use as a coating material to capture VN onto implant surfaces...
September 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28941013/deoxycholic-acid-promotes-development-of-gastroesophageal-reflux-disease-and-barrett-s-oesophagus-by-modulating-integrin-%C3%AE-v-trafficking
#18
David O Prichard, Anne Marie Byrne, James O Murphy, John V Reynolds, Jacintha O'Sullivan, Ronan Feighery, Brendan Doyle, Osama Sharaf Eldin, Stephen P Finn, Aoife Maguire, Deirdre Duff, Dermot P Kelleher, Aideen Long
The fundamental mechanisms underlying erosive oesophagitis and subsequent development of Barrett's oesophagus (BO) are poorly understood. Here, we investigated the contribution of specific components of the gastric refluxate on adhesion molecules involved in epithelial barrier maintenance. Cell line models of squamous epithelium (HET-1A) and BO (QH) were used to examine the effects of bile acids on cell adhesion to extracellular matrix proteins (Collagen, laminin, vitronectin, fibronectin) and expression of integrin ligands (α3 , α4, α5 , α6 and αν )...
September 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28937683/a-vitronectin-derived-peptide-reverses-ovariectomy-induced-bone-loss-via-regulation-of-osteoblast-and-osteoclast-differentiation
#19
Seung-Ki Min, Hyun Ki Kang, Sung Youn Jung, Da Hyun Jang, Byung-Moo Min
Osteoporosis affects millions of people worldwide by promoting bone resorption and impairing bone formation. Bisphosphonates, commonly used agents to treat osteoporosis, cannot reverse the substantial bone loss that has already occurred by the time of diagnosis. Moreover, their undesirable side-effects, including osteonecrosis of the jaw, have been reported. Here, we demonstrated that a new bioactive core vitronectin-derived peptide (VnP-16) promoted bone formation by accelerating osteoblast differentiation and activity through direct interaction with β1 integrin followed by FAK activation...
September 22, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28916983/surface-changes-of-nanotopography-by-carbon-ion-implantation-to-enhance-the-biocompatibility-of-silicone-rubber-an-in-vitro-study-of-the-optimum-ion-fluence-and-adsorbed-protein
#20
Xianhui Li, Xin Zhou, Yao Chen, Shu Yu, Xin Chen, Xin Xia, Xiaohua Shi, Yiming Zhang, Dongli Fan
Lower cellular adhesion and dense fibrous capsule formation around silicone breast implants caused by lower biocompatibility is a serious clinical problem. Preliminary work has shown that ion implantation enhances cell adhesion. Whether the biocompatibility is further enhanced by higher doses of carbon ion implantation and the mechanism by which ion implantation enhances biocompatibility remain unclear. In this study, five doses of carbon ions, which gradually increase, were implanted on the surface of silicone rubber and then the surface characteristics were surveyed...
September 15, 2017: Journal of Materials Science. Materials in Medicine
keyword
keyword
7620
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"