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Tissue plasminogen activator

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https://www.readbyqxmd.com/read/29234445/bioactivity-guided-fractionation-of-the-traditional-chinese-medicine-resina-draconis-reveals-loureirin-b-as-a-pai-1-inhibitor
#1
Yu Jiang, Guangping Zhang, Dong Yan, Hong Yang, Zuguang Ye, Tonghui Ma
Thrombotic diseases have become a global burden due to morbidity, mortality, and disability. Traditional Chinese medicine has been proven effective in removing blood stasis and promoting blood circulation, but the exact mechanisms remain unclear. Plasminogen activator inhibitor-1 (PAI-1) is a natural inhibitor of tissue-type and urokinase-type plasminogen activators. In this study, we screened four fractions of Resina Draconis (a traditional Chinese medicine) extract for PAI-1 inhibitory activity. Bioactivity-guided purification and chromogenic substrate-based assay led to the identification of loureirin B as the major PAI-1 inhibitor, with an IC50 value of 26...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29232256/prognosis-comparisons-in-acute-ischemic-stroke-patients-with-thrombolysis-and-nonthrombolysis-therapy-a-retrospective-study-with-larger-sample-size
#2
Haojun Li, Yupeng Wu
: We compared the short-term, middle-term and long-term primary outcomes between thrombolysis and nonthrombolysis therapy in acute ischemic stroke (AIS) patients. Medical records were collected from patients suffered from AIS between 2010 and 2013 and allocated into either the intravenous recombinant tissue plasminogen activator (as rt-PA group) treatment, or non-rt-PA treatment group (as control group). The primary outcomes included a proportion of patients with favorable outcome [as defined with a modified Rankin Scale (mRS) of 0-1], functional independence (mRS of 0-2) or with bad outcome (mRS of 5-6) at 3, 6 and 12 months and the overall mortality...
December 11, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29224744/low-versus-standard-dose-intravenous-tissue-type-plasminogen-activator-for-acute-ischemic-stroke-an-updated-meta-analysis
#3
Huihui Liu, Huaguang Zheng, Yongjun Cao, Yuesong Pan, David Wang, Runhua Zhang, Shoujiang You, Xinmiao Zhang, Shuya Li, Xu Tong, Chun-Feng Liu, Yilong Wang
BACKGROUND: We performed a meta-analysis to compare the efficacy and safety between low- and standard-dose intravenous (IV) tissue-type plasminogen activator (tPA) for acute ischemic stroke (AIS) patients within 4.5 hours of symptom onset. METHODS: We searched PubMed and EMBASE for relevant studies from inception to June1, 2017. Cohort or randomized controlled studies for AIS within 4.5 hours of symptom onset with comparison between low-dose and standard-dose tPA were included...
December 7, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29222229/visual-aids-for-patient-family-and-physician-decision-making-about-endovascular-thrombectomy-for-acute-ischemic-stroke
#4
Ivie Tokunboh, Marta Vales Montero, Matheus Fellipe Zopelaro Almeida, Latisha Sharma, Sidney Starkman, Viktor Szeder, Reza Jahan, David Liebeskind, Nestor Gonzalez, Andrew Demchuk, Michael T Froehler, Mayank Goyal, Maarten G Lansberg, Helmi Lutsep, Lee Schwamm, Jeffrey L Saver
BACKGROUND AND PURPOSE: Rapid decision making optimizes outcomes from endovascular thrombectomy for acute cerebral ischemia. Visual displays facilitate swift review of potential outcomes and can accelerate decision processes. METHODS: From patient-level, pooled randomized trial data, 100 person-icon arrays (Kuiper-Marshall personographs) were generated showing beneficial and adverse effects of endovascular thrombectomy for patients with acute cerebral ischemia and large vessel occlusion using (1) automated (algorithmic) and (2) expert-guided joint outcome table specification...
December 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29221968/clinical-study-of-intravenous-low-dose-recombinant-tissue-plasminogen-activator-for-acute-cerebral-infarction-comparison-of-treatment-within-3%C3%A2-hours-versus-3-4-5%C3%A2-hours
#5
Ichiro Deguchi, Norio Tanahashi, Masaki Takao
BACKGROUND: An intravenous recombinant tissue plasminogen activator (rt-PA, alteplase .6 mg/kg) for acute cerebral infarction within 3 hours of onset was approved in Japan in 2005. The treatment window was subsequently extended to within 4.5 hours of onset. However, few Japanese studies have compared the efficacy and safety of rt-PA therapy between patients treated within 3 hours and patients treated within 3-4.5 hours. METHODS: This study included 323 patients who received rt-PA for acute cerebral infarction within 3 hours or 3-4...
December 5, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29221347/safe-administration-of-intrapleural-alteplase-during-pregnancy
#6
Heather Torbic, Hanine Inaty, Siva Raja, Humberto Choi
Instillation of intrapleural (IP) fibrinolytics has been used in patients with complicated parapneumonic pleural effusions to improve fluid drainage and decrease the need for surgical intervention. However, clinical trials have not included certain special populations such as pregnant females and there are currently no published case reports of this practice in this group. We describe the case of a 35-year-old female, G2P1 at 32 weeks of gestation, with a complicated pleural effusion due to influenza pneumonia with superimposed bacterial pneumonia...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29217666/epac1-regulates-endothelial-annexin-a2-cell-surface-translocation-and-plasminogen-activation
#7
Wenli Yang, Fang C Mei, Xiaodong Cheng
Annexins, a family of highly conserved calcium- and phospholipid-binding proteins, play important roles in a wide range of physiologic functions. Among the 12 known annexins in humans, annexin A2 (AnxA2) is one of the most extensively studied and has been implicated in various human diseases. AnxA2 can exist as a monomer or a heterotetrameric complex with S100A10 (P11) and plays a critical role in many cellular processes, including exocytosis, endocytosis, and membrane organization. At the endothelial cell surface, the (AnxA2·P11)2 tetramer-acting as a coreceptor for plasminogen and tissue plasminogen activator (tPA)-accelerates tPA-dependent activation of the fibrinolytic protease, plasmin, the enzyme that is responsible for thrombus dissolution and the degradation of fibrin...
December 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29217365/alberta-stroke-program-early-ct-score-time-score-predicts-outcome-after-endovascular-therapy-in-patients-with-acute-ischemic-stroke-a-retrospective-single-center-study
#8
Kenichi Todo, Nobuyuki Sakai, Tomoyuki Kono, Taku Hoshi, Hirotoshi Imamura, Hidemitsu Adachi, Hiroshi Yamagami, Nobuo Kohara
BACKGROUND: Clinical outcomes after successful endovascular therapy in patients with acute ischemic stroke are associated with several factors including onset-to-reperfusion time (ORT), the National Institute of Health Stroke Scale (NIHSS) score, and the Alberta Stroke Program Early CT Score (ASPECTS). The NIHSS-time score, calculated as follows: [NIHSS score] × [onset-to-treatment time (h)] or [NIHSS score] × [ORT (h)], has been reported to predict clinical outcomes after intravenous recombinant tissue plasminogen activator therapy and endovascular therapy for acute stroke...
December 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29216534/thrombolytic-therapy-based-on-fucoidan-functionalized-polymer-nanoparticles-targeting-p-selectin
#9
Maya Juenet, Rachida Aid-Launais, Bo Li, Alice Berger, Joël Aerts, Véronique Ollivier, Antonino Nicoletti, Didier Letourneur, Cédric Chauvierre
Injection of recombinant tissue plasminogen activator (rt-PA) is the standard drug treatment for thrombolysis. However, rt-PA shows risk of hemorrhages and limited efficiency even at high doses. Polysaccharide-poly(isobutylcyanoacrylate) nanoparticles functionalized with fucoidan and loaded with rt-PA were designed to accumulate on the thrombus. Fucoidan has a nanomolar affinity for the P-selectin expressed by activated platelets in the thrombus. Solid spherical fluorescent nanoparticles with a hydrodynamic diameter of 136 ± 4 nm were synthesized by redox radical emulsion polymerization...
November 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/29212747/primary-thrombectomy-in-tpa-tissue-type-plasminogen-activator-eligible-stroke-patients-with-proximal-intracranial-occlusions
#10
Urs Fischer, Johannes Kaesmacher, Carlos A Molina, Magdy H Selim, Andrei V Alexandrov, Georgios Tsivgoulis
No abstract text is available yet for this article.
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29212743/successful-reperfusion-with-intravenous-thrombolysis-preceding-mechanical-thrombectomy-in-large-vessel-occlusions
#11
Georgios Tsivgoulis, Aristeidis H Katsanos, Peter D Schellinger, Martin Köhrmann, Panayiotis Varelas, Georgios Magoufis, Maurizio Paciaroni, Valeria Caso, Anne W Alexandrov, Edip Gurol, Andrei V Alexandrov
BACKGROUND AND PURPOSE: Although current guidelines advocate pretreatment with intravenous thrombolysis (IVT) in all eligible patients with acute ischemic stroke with large-vessel occlusion before mechanical thrombectomy, there are observational data questioning the efficacy of this approach. One of the main arguments in favor of IVT pretreatment is the potential for tissue-type plasminogen activator-induced successful reperfusion (SR) before the onset of endovascular procedure. METHODS: We performed a systematic review and meta-analysis of randomized controlled clinical trials and observational cohorts providing rates of SR with IVT in patients with large-vessel occlusion before the initiation of mechanical thrombectomy...
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29212289/a-novel-thrombolytic-and-anticoagulant-serine-protease-from-polychaeta-diopatra-sugokai
#12
Hye Jin Kim, Kyou Hee Shim, Seung Ju Yeon, Hwa Sung Shin
Ischemic stroke can result from blockage of blood vessels, forming fibrin clots in the body and causing irreparable brain damage. Remedial thrombolytic agents or anticoagulants have been studied; however, because the FDA-approved tissue plasminogen activator (t-PA) has low efficacy and side effects, it is necessary to develop safer and more effective treatment candidates. This study was aimed at assessing the fibrinolytic and anticoagulation features of a novel serine protease extracted and purified from Diopatra sugokai, a polychaeta that inhabits tidal flats...
December 8, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29211671/pharmacomechanical-catheter-directed-thrombolysis-for-deep-vein-thrombosis
#13
Suresh Vedantham, Samuel Z Goldhaber, Jim A Julian, Susan R Kahn, Michael R Jaff, David J Cohen, Elizabeth Magnuson, Mahmood K Razavi, Anthony J Comerota, Heather L Gornik, Timothy P Murphy, Lawrence Lewis, James R Duncan, Patricia Nieters, Mary C Derfler, Marc Filion, Chu-Shu Gu, Stephen Kee, Joseph Schneider, Nael Saad, Morey Blinder, Stephan Moll, David Sacks, Judith Lin, John Rundback, Mark Garcia, Rahul Razdan, Eric VanderWoude, Vasco Marques, Clive Kearon
BACKGROUND: The post-thrombotic syndrome frequently develops in patients with proximal deep-vein thrombosis despite treatment with anticoagulant therapy. Pharmacomechanical catheter-directed thrombolysis (hereafter "pharmacomechanical thrombolysis") rapidly removes thrombus and is hypothesized to reduce the risk of the post-thrombotic syndrome. METHODS: We randomly assigned 692 patients with acute proximal deep-vein thrombosis to receive either anticoagulation alone (control group) or anticoagulation plus pharmacomechanical thrombolysis (catheter-mediated or device-mediated intrathrombus delivery of recombinant tissue plasminogen activator and thrombus aspiration or maceration, with or without stenting)...
December 7, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29210632/role-of-matrix-metalloproteinases-in-degenerative-kidney-disorders
#14
Shifa Narula, Chanderdeep Tandon, Simran Tandon
Matrix metalloproteinases (MMPs) are members of calcium dependent-zinc containing endopeptidases that play a pivotal role in extracellular matrix (ECM) remodeling. MMPs are also known to cleave non-matrix proteins, including cell surface receptors, TNF-α, angiotensin-II, growth factors, (especially transforming growth factor-β1, ΤGF-β1) plasminogen, endothelin and other bioactive molecules. The tissue inhibitors of metalloproteinases (TIMPs) inhibit the activity of MMPs and decrease ECM degradation. Various patho-physiological conditions have been linked with the imbalance of ECM synthesis and degradation...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29209450/zinc-chelation-promotes-streptokinase-induced-thrombolysis-in-vitro
#15
Zihui Wang, Xinge Yu, Yang V Li
Cardiovascular disorder occurs when a local blood clot obstructs an artery or a vein to its surround organs, causing related tissues to lose function and die. It is one of the leading causes of mortality and a major cause of disability. The effect of thrombolysis induced by injecting intravenous thrombolytic agents is critical for reducing tissue damages. Streptokinase (SK) is a widely used thrombolytic agent in the treatment of thromboembolism in the blood vessels. A high unit of streptokinase is used in thrombolytic therapies for thrombotic disorders and could improve tissue reperfusion...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29205017/drip-and-ship-stroke-thrombolysis-in-the-emergency-department-of-a-healthcare-center-a-possibility-for-those-fallen-ill-in-rural-settings
#16
Joonas H Kauppila, Lasse Raatiniemi, Juha-Matti Isokangas, Matti Martikainen, Katja Piironen
Thrombolysis with tissue plasminogen activator is the mainstay in the treatment of acute stroke. Reducing the delay of thrombolysis treatment improves patient prognosis and reduces the incidence of complications. Variable telestroke regimens have improved the availability of stroke thrombolysis, especially in rural settings, where neurologists are not readily available. In the drip-and-ship strategy, stroke thrombolysis is initiated in a peripheral hospital and the patient is then transferred to a tertiary care unit...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29203753/-definition-and-treatment-of-stroke-over-the-centuries
#17
Anna Starostka-Tatar, Beata Łabuz-Roszak, Michał Skrzypek, Mariusz Gąsior, Marek Gierlotka
Stroke was already diagnosed in the ancient times. For hundreds of years the treatment of this disease has changed radically. According to the current WHO definition, stroke is a clinical syndrome caused by focal or generalized brain injury that lasts more than 24 hours or leads to death and has no other cause than vascular. Stroke constitutes a big social and economic problem, as it can lead to death or disability. In the highly developed countries stroke is the third most common cause of adult deaths, the second leading cause of dementia, and the most common cause of disability...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29202210/differential-effects-on-haemostatic-markers-by-metformin-and-the-contraceptive-pill-a-randomized-comparative-trial-in-pcos
#18
Genia F Burchall, Terrence J Piva, Sanjeeva Ranasinha, Helena J Teede
Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objective To investigate and compare haemostatic impacts of common pharmacological treatments and explore relationships with hormonal and metabolic variables in PCOS. Patients/Methods This mechanistic sub-study using biobanked samples from a 6-month randomized comparative trial of pharmacological treatments assessed pro- and anti-thrombotic markers and overall haemostatic activity...
November 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29201189/mir-30c-may-serve-a-role-in-endometriosis-by-targeting-plasminogen-activator-inhibitor-1
#19
Xiaoli Chen, Yan Jiang, Dianling Pan
The present study aimed to investigate the role of miR-30c in endometriosis (EMs) and the underlying mechanism. The expression of miR-30c and plasminogen activator inhibitor type 1 (PAI-1) mRNA in EMs tissues was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and the expression of PAI-1 protein was detected by western blot analysis. The proliferation, migration, invasion and adhesion of endometrial stromal cells (ESCs) in different groups transfected with miR-30c mimic or inhibitor were compared...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29198901/does-the-primary-imaging-modality-computed-tomography-or-magnetic-resonance-imaging-influence-stroke-physicians-certainty-on-whether-or-not-to-give-thrombolysis-to-randomized-acute-stroke-patients
#20
Christine Krarup Hansen, Anders Christensen, Helen Rodgers, Inger Havsteen, Christina Kruuse, Hanne Christensen
BACKGROUND: Door-to-needle time of 20 minutes to stroke patients with intravenous tissue plasminogen activator (iv-tPA) is feasible when computed tomography (CT) is used as first-line of brain imaging. Magnetic resonance imaging (MRI)-based assessment is more time-consuming but superior in detecting acute ischemia. The certainty with which stroke physicians prescribe or refrain from giving iv-tPA treatment to CT- versus MRI-examined patients has not previously been studied. The aim of the present study was to determine the effect of a primary imaging strategy of CT or MRI on clinicians' certainty to prescribe or refrain from giving iv-tPA to patients with suspected acute stroke...
November 30, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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