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Antinuclear antibodies 1:80

Helen C S Meier, Dale P Sandler, Eleanor M Simonsick, Christine G Parks
BACKGROUND: Vitamin D deficiency is associated with cancer and autoimmune diseases, but little is known about the association between vitamin D and antinuclear antibodies (ANA), a biomarker of immune dysfunction in healthy populations. The objective of this study was to determine if vitamin D deficiency is associated with ANA in middle age and older U.S. adults. METHODS: A cross-sectional analysis using the National Health and Nutrition Examination Survey (NHANES) 2001-2004 was conducted...
August 19, 2016: Cancer Epidemiology, Biomarkers & Prevention
Irena Orságová, Luděk RoŽnovský, Lenka Petroušová, Michaela Konečná, Libuše Kabieszová, Jan Martinek, Alena Kloudová, Ladislav Pavliska
OBJECTIVE: To determine the prevalence of autoimmune parameters in patients with chronic hepatitis B and C (HBV, HCV) treated with conventional or pegylated interferon alpha (IFN) and monitor the development of autoimmune diseases in connection with this treatment. PATIENTS AND METHODS: In the years 1992-2014, autoimmune parameters were evaluated in 324 patients (271 with HCV, 53 with HBV) treated with IFN at the Department of Infectious Diseases in Ostrava. Prior to, during and after completion of IFN treatment, antinuclear antibodies (ANA), antimitochondrial antibodies (AMA), smooth muscle antibodies (SMA), anti-liver/kidney microsomal antibodies (anti-LKM-1), anti-double-stranded DNA antibodies (anti-ds-DNA), antibodies against granulocytes (ANCA), anti-deoxyribonucleoprotein antibodies (anti-DNP), anti-nucleosomes antibodies, rheumatoid factor (RF) and circulating immune complexes (CIC) were determined and clinical manifestations of autoimmune diseases were evaluated...
June 2016: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
Anne E Depincé-Berger, Amelie Moreau, Virginie Bossy, Christian Genin, Melanie Rinaudo, Stephane Paul
BACKGROUND: Indirect immunofluorescence plays a major role in the detection of antinuclear antibodies (ANAs) and follow-up of their titers in the context of connective tissue diseases. Given the numerous unfavorable features of the conventional manual reading of HEP2 slides (need of time and expert morphologists for the reading, lack of standardization, subjectivity of the interpretation), the biomedical industry has developed automated techniques of slide preparation and microscope reading...
September 2016: Journal of Clinical Laboratory Analysis
Hana Jedlickova, Veronika Durčanská, Vladimír Vašků
Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported. We describe 4 patients with paraneoplastic scleroderma who were treated at the I. Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014. The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland. In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy...
April 2016: Acta Dermatovenerologica Croatica: ADC
Aylin Demirezer Bolat, Fatma Ebru Akın, Mustafa Tahtacı, Öykü Tayfur Yürekli, Hüseyin Köseoğlu, Şükran Erten, Murat Başaran, Eyüp Selvi, Şemnur Büyükaşık, Osman Ersoy
AIM: To define the prevalence of polyautoimmunity (PAI) among celiac disease (CD) patients and to compare clinical and laboratory features of CD patients with or without PAI in order to determine the risk factors for PAI in CD. MATERIAL AND METHOD: Patients diagnosed with CD in our clinic between 2007 and 2014 with at least 1 year of follow-up were retrospectively evaluated. Totally 145 patients were included in the study. Information on patient demographics and laboratory data were obtained from patient records...
2015: Digestion
Rena Kaneko, Chitose Ohishi, Miniru Kim, Masaaki Shiina, Satoshi Kusayanagi, Masazumi Ogawa, Kazuo Munakata, Kyoichi Mizuno, Yuzuru Sato
Two cases of severe liver injury and positive result for antinuclear antibodies induced by food additives are reported. The first patient reported long-term intake of Mabo Ramen(®) noodle soup, nutritional supplements, and over-the-counter drugs. Total bilirubin, aspartate aminotransferase, and alanine aminotransferase were 9.6 mg/dL, 1,048, and 1,574 IU/L, respectively. Antinuclear antibody was 80×. The drug-induced lymphocyte stimulation test (DLST) was positive for Mabo Ramen(®) and its additives such as Xanthan gum, guar gum, and Doubanjiang...
August 2012: Clinical Journal of Gastroenterology
Sujan Ravi, Mohamed Shoreibah, Evan Raff, Joseph Bloomer, Donny Kakati, Khalid Rasheed, Ashwani K Singal
BACKGROUND AND AIM: Autoimmune (AI) markers are reported in patients with steatohepatitis-related liver disease. However, their clinical significance is unclear. METHODS: Charts of patients due to alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD) were stratified for antinuclear antigen (ANA > 1:80), antismooth muscle antibody (ASMA > 1:40), or antimitochondrial antibody (AMA > 1:20). Study outcomes were patient survival and complications of liver disease...
December 2015: Digestive Diseases and Sciences
Antonio Carroccio, Alberto D'Alcamo, Francesca Cavataio, Maurizio Soresi, Aurelio Seidita, Carmelo Sciumè, Girolamo Geraci, Giuseppe Iacono, Pasquale Mansueto
BACKGROUND & AIMS: There is much interest in wheat sensitivity among people without celiac disease (CD), but little is known about any risks associated with the condition. We evaluated the prevalence of autoimmune diseases (ADs) among patients with nonceliac wheat sensitivity (NCWS), and investigated whether they carry antinuclear antibodies (ANA). METHODS: We performed a retrospective study of 131 patients diagnosed with NCWS (121 female; mean age, 29.1 years) at 2 hospitals in Italy from January 2001 through June 2011...
September 2015: Gastroenterology
R Sakthiswary, S Rajalingam, M R Norazman, H Hussein
OBJECTIVE: The etiology of recurrent pregnancy loss (RPL) is unknown in a significant proportion of patients. Autoimmune processes have been implicated in the pathogenesis. The role of antinuclear antibody (ANA) in this context is largely undetermined. In an attempt to address the lack of evidence in this area, we explored the clinical significance of antinuclear antibody (ANA) in unexplained RPL. MATERIALS AND METHODS: We studied 68 patients with RPL and 60 healthy controls from September 2005 to May 2012...
2015: La Clinica Terapeutica
Jiaxin Zhou, Dong Xu, Yong Hou, Qian Wang, Mengtao Li, Xiaofeng Zeng
OBJECTIVE: To analyze the clinical features, laboratory tests, treatments and outcome of patients with scleroderma renal crisis (SRC). METHODS: We retrospectively reviewed the clinical and laboratory data of 16 patients with scleroderma renal crisis in Peking Union Medical College Hospital from May 2004 to May 2013. The treatment and outcome of SRC patients were also retrospectively analyzed. RESULTS: There were a total of 16 SRC patients including 5 male patients and 11 females...
February 2015: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Yun Zhao, Ya Li, Li Wang, Xiao-Feng Li, Ci-Bo Huang, Guo-Chun Wang, Xue-Wu Zhang, Zhuo-Li Zhang, Xiao Zhang, Wei-Guo Xiao, Lie Dai, Yong-Fu Wang, Shao-Xian Hu, Hong-Bin Li, Lu Gong, Bin Liu, Ling-Yun Sun, Miao-Jia Zhang, Xuan Zhang, Yong-Zhe Li, De-Shun Du, Shun-Hua Zhang, Yuan-Yuan Sun, Feng-Chun Zhang
The epidemiological characteristics of Sjögren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey the epidemiological characteristics of primary SS in China. We recruited 483 primary SS patients from 16 Chinese medical centers nationwide from January 2009 to November 2011 and assessed salivary and lacrimal gland dysfunction, organ involvement, and autoimmunity in these patients. The cohort included 456 women and 27 men (ratio, 17:1; mean age at onset, 42 ± 11 years; median age at diagnosis, 49 years; range, 41-56 years)...
April 2015: Medicine (Baltimore)
Sana En-Nasri, Zineb Fouad, Wafaa Fadili, Selma Hassani, Amal Said, Lamiaa Essaadouni, Inass Laouad
BACKGROUND: Lupus nephritis is a common and serious damage in systemic lupus erythematosus. The aim of our study is to define the frequency and to identify the predictors of lupus nephritis in patients with systemic lupus erythematosus. METHODS: multicenter retrospective study on all systemic lupus erythematosus patients followed between 2005 and 2012. We analyzed the epidemiological, clinical and biological presentation at admission and during follow-up. We have identified two groups of patients: group 1 involving systemic lupus erythematosus without renal disease, group 2 : patient with lupus nephritis...
October 2014: La Tunisie Médicale
Doaa Mohammed Youssef, Doaa Mostafa Tawfek, Abdelsalam Mohammed Mohammed, Rania Mohammed, Naglaa Ahmed Khalifa
Clinical manifestations of systemic lupus erythematosus (SLE) are widely variable, and its course is unpredictable. SLE that begins in childhood has been considered more severe than SLE with onset during adulthood. Our aim was to determine the presentation and the outcome of SLE of 26 children (20 females and 6 males, with a female to male ratio of 3.8:1) with SLE in our center, their ages ranging from 5 - 18 years and followed from 2005 till October 2011. They were diagnosed according to the American Rheumatism Association's revised criteria...
March 2015: Saudi Journal of Kidney Diseases and Transplantation
Emily C Somers, Martha A Ganser, Jeffrey S Warren, Niladri Basu, Lu Wang, Suzanna M Zick, Sung Kyun Park
BACKGROUND: Immune dysregulation associated with mercury has been suggested, although data in the general population are lacking. Chronic exposure to low levels of methylmercury (organic) and inorganic mercury is common, such as through fish consumption and dental amalgams. OBJECTIVE: We examined associations between mercury biomarkers and antinuclear antibody (ANA) positivity and titer strength. METHODS: Among females 16-49 years of age (n = 1,352) from the National Health and Nutrition Examination Survey (NHANES) 1999-2004, we examined cross-sectional associations between mercury and ANAs (indirect immunofluorescence; cutoff ≥ 1:80)...
August 2015: Environmental Health Perspectives
Upul G P Pathirana, Nirmali Gunawardena, Hiranya Abeysinghe, Hannah Charlotte Copley, M G Dhammika Somarathne
INTRODUCTION: Acquired haemophilia A is a rare life- and limb-threatening bleeding disorder if left untreated. Autoimmune thyroiditis is an autoimmune disorder that can be rarely associated with acquired haemophilia. Here we report a case of a 60-year-old woman presenting with cutaneous and muscle haematomas secondary to acquired haemophilia A in association with autoimmune thyroiditis, who was successfully treated with recombinant activated factor VII and immunosuppression. CASE PRESENTATION: A 60-year-old Sri Lankan woman with a background of longstanding hypothyroidism, diabetes mellitus, hypertension, hyperlipidaemia and bronchial asthma developed spontaneous cutaneous purpura and a limb-threatening intramuscular haematoma...
2014: Journal of Medical Case Reports
Yongkang Wu, Bei Cai, Weihua Feng, Bin Yang, Zhuochun Huang, Chuan Zuo, Lanlan Wang
BACKGROUND & OBJECTIVES: The presence of CD4+CD8+ (double positive) T cells (DPT) in the target organs of several autoimmune diseases has been reported. The aim of this study was to investigate the pathogenic role of DPT in systemic lupus erythematosus (SLE). METHODS: A total of 175 SLE cases and 125 matched healthy controls were investigated for CD3+, CD4+, CD8+ lymphocytes and DPT by flow cytometry. Serum samples from SLE patients and controls were tested for antinuclear antibody (ANA), anti-double strain deoxyribonucleic acid (anti-dsDNA), anti-U1 ribonucleoprotein (anti-U1 RNP), anti-sjogren syndrome A (anti-SSA), anti-ribosomal P protein (anti-rib-P), anti-Smith (anti-Sm), anti-Sjogren syndrome B (anti-SSB), complement 3 (C3) and complement 4 (C4)...
October 2014: Indian Journal of Medical Research
Ahmed Alansari, Luis Quiel, Noella Boma
A 77-year-old woman presented to the emergency department with a 2-day history of nausea and vomiting. Her medical history included diabetes mellitus, hypertension, atrial fibrillation, dilated cardiomyopathy, and coronary artery disease. Her home medications included aspirin, clopidogrel, warfarin, digoxin, metoprolol, losartan, simvastatin, isosorbide dinitrate, furosemide, and spironolactone. Initial physical examination showed blood pressure of 170/80 mm Hg with a heart rate of 69 beats per minute, otherwise unremarkable...
July 2016: American Journal of Therapeutics
Ricardo Serrano-Osuna, Rocío Milagro López-López, Olga Rosa Brito-Zurita, Enrique Sabag-Ruiz, Héctor Pérez-Fernández, José Manuel Ornelas-Aguirre
BACKGROUND: Antinuclear antibodies are immunoglobulins that recognize autologous nuclear and cytoplasmic cellular components. In healthy persons they are not associated with autoimmune disease. However, they may be related to an immune risk phenotype that has not been sufficiently studied. We undertook this study to examine the presence of antinuclear antibodies in serum from blood donors. METHODS: Cross-sectional study on 379 blood donors between 18 and 65 years old...
November 2014: Cirugia y Cirujanos
Mirko Scarsi, Antonella Radice, Francesca Pregnolato, Veronique Ramoni, Chiara Grava, Laura Bianchi, Maria Gerosa, Marta Mosca, Anna Ghirardello, Chiara Tani, Mario Motta, Marzia Quinzanini, Angela Tincani, Amelia Ruffatti, Paola Migliorini, Andrea Doria, Pier Luigi Meroni, Antonio Brucato
OBJECTIVES: To verify the association between the presence of specific anti-52 Ro/SSA-p200 antibodies and congenital heart block (CHB). METHODS: 207 pregnant Italian women carrying anti-Ro/SSA Ab were retrospectively evaluated. Anti-p200 Ab were investigated in the mothers' sera by ELISA (Euro-Diagnostica,Wieslab SS-A p200). RESULTS: CHB occurred in 42 children (34 complete CHB), whereas 165 were not affected. All CHB cases were previously identified with an ELISA screening for anti-Ro/SSA 60 kD Ab...
November 2014: Clinical and Experimental Rheumatology
G Mascioli, C Lombardi, F Franceschini, M Metra, E Lucca, F Michelotti, F Canevese, N Bakhtadze, C Belvito, E Sciatti, E Vizzardi, L Bontempi, A Curnis
AIM: Cardiac resynchronization therapy (CRT) is an effective therapy for patients with reduced systolic function and enlarged QRS. Recently, some Authors have demonstrated that the presence of positive antinuclear antibodies (ANAs) may play a role in the development of heart failure in a population of patients implanted with PM. METHODS: We investigated the effect of positive ANAs in 90 patients (mean age 71±8 years) implanted with a CRT device in our Centre between May 2010 and June 2013...
December 2015: Minerva Cardioangiologica
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