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JOURNAL ARTICLE
Tomoya Watanabe, Yasushi Ototake, Asami Akita, Mao Suzuki, Miwa Kanaoka, Jun Tamura, Yusuke Saigusa, Yukie Yamaguchi
BACKGROUND: Anti-SS-A/Ro antibody (anti-SSA), the diagnostic marker of Sjögren's syndrome (SS), is often detected in systemic sclerosis (SSc). Some patients are diagnosed with SSc/SS overlap syndromes, while there are anti-SSA-positive SSc cases without SS. In this study, we investigated the clinical characteristics of SSc with anti-SSA and clarified the clinical impact of this antibody in SSc. METHODS: A retrospective chart review was conducted of 156 patients with SSc at Yokohama City University Hospital from 2018 to 2021...
May 3, 2024: Arthritis Research & Therapy
#2
JOURNAL ARTICLE
M S Mohd Razi, Y Sugumaran, N A Mohd Haniz, K Khilmie, A H Osmera, E J Jauhary, A A Wahab
INTRODUCTION: Anti-nuclear antibody (ANA) testing is among the most common immunological test requested in the diagnostic immunology laboratory. The main purpose of this test is to screen for the underlying systemic autoimmune rheumatic diseases (SARDs). The gold standard laboratory method for ANA detection is by the indirect immunofluorescence (IIF) assay. In most laboratories, positive ANA-IIF is reported in terms of titration and pattern. OBJECTIVE: This study was conducted with the aim of determining the correlation between ANA-IIF titration and pattern for the diagnosis of SARDs...
April 2024: Malaysian Journal of Pathology
#3
JOURNAL ARTICLE
Mahadi B Alyami, Mohammed N Hakeem, Abdulaziz I Fadil, Bassim A Jee, Hamza M ElAbbasy, Ghada Ankawi
Objectives Antinuclear antibodies (ANA) are autoantibodies that are associated with and ordered to diagnose autoimmune connective tissue disease. ANA have high sensitivity (~98%) but low specificity (~75%), and because they can be found in healthy individuals and non-rheumatologic conditions leading to their elevation, ANA tests are often requested and interpreted inappropriately by clinicians. The aim of this study was to retrospectively assess how frequently ANA testing is repeated in the adult population of Saudi Arabia (SA) and which factors are associated with and lead to inappropriate testing...
January 2024: Curēus
#4
JOURNAL ARTICLE
Atsuto Mouri, Kyoichi Kaira, Ou Yamaguchi, Kosuke Hashimoto, Yu Miura, Ayako Shiono, Tomonori Kawasaki, Kunihiko Kobayashi, Hisao Imai, Hiroshi Kagamu
BACKGROUND: The relationship between antinuclear antibody (ANA) and the efficacy of programmed death-1 (PD-1) blockade remains controversial. Here, we investigated the prognostic significance of ANA titer in patients with non-small cell lung cancer (NSCLC) receiving pembrolizumab monotherapy as the first-line treatment, compared with that of platinum-based chemotherapy with PD-1 blockade. METHODS: Our clinical data based on the ANA titer (1:80) were retrospectively reviewed for patients with advanced NSCLC, who were treated with first-line pembrolizumab monotherapy and platinum-based chemotherapy with PD-1 blockade...
December 31, 2023: International Journal of Clinical Oncology
#5
JOURNAL ARTICLE
Gábor Nagy, Róza Földesi, István Csípő, Tünde Tarr, Gabriella Szűcs, Antónia Szántó, Tamás Bubán, Zoltán Szekanecz, Mária Papp, János Kappelmayer, Péter Antal-Szalmás
BACKGROUND: A major challenge of the HEp-2 cell-based indirect immunofluorescence (IIF) assays is the correct identification of the individual anti-nuclear antibodies (ANAs) if more than one is present in a sample. We created artificial mixes by pooling two different samples with a single autoantibody in different titers. Comparison of the expected and observed patterns and titers clarifies the interference between the two tested ANAs. METHODS: Serum samples with a single homogeneous or speckled ANA pattern were serially diluted and mixed in 16 combinations, providing end-point titers of 1:5,120 to 1:80 for both patterns...
December 26, 2023: Clinica Chimica Acta; International Journal of Clinical Chemistry
#6
JOURNAL ARTICLE
Agnieszka Winikajtis-Burzyńska, Marek Brzosko, Hanna Przepiera-Będzak
The aim of this study was to analyze the relationship between the serum levels of soluble transferrin receptor (sTfR) and interleukin 4 (IL-4), and the disease activity and organ manifestations in SLE patients. We studied 200 SLE patients and 50 controls. We analyzed disease activity, organ involvement, serum sTfR, IL-4 and interleukin-6 (IL-6) levels, and antinuclear and antiphospholipid antibody profiles. The median serum levels of sTfR ( p > 0.000001) and IL-4 ( p < 0.00001) were higher in the study group than in the controls...
December 11, 2023: International Journal of Molecular Sciences
#7
JOURNAL ARTICLE
Yu Fei Li, Ya Ni Yan, Jia Yang Jin, Chun Li, Qiu Yan Pei
OBJECTIVE: To investigate the clinical manifestations and laboratory indicators of anti-Sjögren's-syndrome-related antigen A (SSA) antibody associated fetal cardiac disease. METHODS: Pregnant women hospitalized at Peking University People's Hospital from January 2013 to July 2023 were included. Eleven patients with anti-SSA antibody positive were eventually diagnosed with fetal cardiac di-sease. And patients with anti-SSA antibody positive without fetal cardiac disease were selected as controls...
December 18, 2023: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
#8
Munawaroh Fitriah, Lita Diah Rahmawati, Indah Adhita Wulanda, Hani Susianti, Betty Agustina Tambunan
Neuropsychiatric systemic lupus erythematosus (NPSLE) exhibits neurological and psychiatric manifestations in systemic lupus erythematosus (SLE) patients, which NPSLE diagnosis can be challenging for rheumatologists. An Indonesian female, 44 years old, complained of two times seizures with 10-min duration, which during seizures were stiff, eyes rolled up, foaming at the mouth, wet the bed, and fainting afterward. The patient also has a history of SLE and received cyclophosphamide therapy 5 years ago. Her clinical condition showed facial and lingual palsy, with central type on the right...
2023: Case Reports in Psychiatry
#9
JOURNAL ARTICLE
Kavita Jain, Archana Rastogi, Sherin S Thomas, Chhagan Bihari
OBJECTIVES: Previous reports on association of autoantibodies with histological severity in nonalcoholic fatty liver disease (NAFLD) have revealed inconsistent results. Therefore, this study was undertaken to find the impact of autoantibodies on histological severity of NAFLD. METHODS: All cases with histological diagnosis of NAFLD during January 2016 to January 2021 were included in the study. Laboratory parameters were recorded, and histological assessment was done...
2023: Journal of Clinical and Experimental Hepatology
#10
JOURNAL ARTICLE
Claudia Canofari, Andrea Vendola, Annamaria Iuliano, Loreta Di Michele, Alfredo Sebastiani, Andreina Gubbiotti, Gian Domenico Sebastiani
INTRODUCTION: Interstitial lung diseases (ILDs) are diseases characterised by excessive deposition of collagen matrices in the pulmonary interstitium. Some of them are considered idiopathic (idiopathic pulmonary fibrosis - IPF), others are related to known pathologies such as connective tissue diseases (CTDs-ILD). Patient affected by ILD and features referable to CTD, not satisfying CTD criteria, are called Interstitial pneumonia with autoimmune features (IPAF) patients. OBJECTIVE: The aim of this report was to investigate clinical and serologic features of a monocentric cohort of patients with IPAF...
June 2023: Mediterranean journal of rheumatology
#11
JOURNAL ARTICLE
Zhenzhen Su, Li Wang, Xuedan Gao, Zhuochun Huang, Jing Hu, Bin Yang
CONTEXT.—: Antinuclear antibodies (ANAs) against certain antigens are useful for identifying autoimmune disorders. Although new solid phase-based immunoassays have been developed for evaluating ANAs, the conventional line immunoassay (LIA) is commonly used in clinical practice. OBJECTIVE.—: To compare the clinical performance of 2 newly developed methods for detecting specific ANAs with LIA. DESIGN.—: Six hundred ninety-six serum samples were collected from 559 patients with autoimmune disease (AID) and 137 controls...
August 18, 2023: Archives of Pathology & Laboratory Medicine
#12
JOURNAL ARTICLE
Jacy T Zanussi, Juan Zhao, Wei-Qi Wei, Gul Karakoc, Cecilia P Chung, QiPing Feng, Nancy J Olsen, C Michael Stein, Vivian K Kawai
BACKGROUND: Antinuclear antibodies (ANA) are antibodies present in several autoimmune disorders. However, a large proportion of the general population (20%) also have a positive test; very few of these individuals will develop an autoimmune disease, and the clinical impact of a positive ANA in them is not known. Thus, we test the hypothesis that ANA + test reflects a state of immune dysregulation that alters risk for some clinical disorders in individuals without an autoimmune disease...
August 7, 2023: BMC rheumatology
#13
JOURNAL ARTICLE
Şengül Beyaz, Serkan Belkaya, Nida Öztop
INTRODUCTION: Pentraxin-3 (PTX3) is a soluble long pentraxin molecule that regulates inflammatory responses. This study aimed to determine the plasma levels of plasma PTX-3 as an inflammation marker in chronic spontaneous urticaria (CSU) and whether the PTX3 levels correlate with disease activity and other clinical parameters, including acute phase reactants and biomarkers. METHODS: The study included 70 CSU patients and 30 healthy controls. Plasma PTX3 levels were measured by ELISA...
2023: Allergologia et Immunopathologia
#14
JOURNAL ARTICLE
M C Sacchi, C Pelazza, M Bertolotti, L Agatea, P De Gaspari, S Tamiazzo, D Ielo, P Stobbione, M Grappiolo, T Bolgeo, P Novel, M M Ciriello, A Maconi
Nowadays, data concerning the risk of autoimmune disease after SARS-CoV-2 (COVID-19) vaccination is controversial. The aim of this single centre prospective follow-up study was to evaluate whether healthcare workers (HCWs) vaccinated with BNT162b2 mRNA and mRNA-1273 will show a development and/or a persistence of autoantibodies, focussing on the detection of antibodies against nuclear antigens (antinuclear antibodies, ANA). We enrolled 155 HCWs, however only 108 of them received the third dose and were considered for further analysis...
December 2023: Autoimmunity
#15
JOURNAL ARTICLE
Minjie Zhang, Jianwei Yin, Xiaoyan Zhang
OBJECTIVES: Interstitial lung disease (ILD) is frequent in patients with rheumatoid arthritis (RA) and is a potentially life-threatening complication with significant morbidity and mortality. This meta-analysis aims to systematically determine the factors associated with the development of rheumatoid arthritis-related interstitial lung disease (RA-ILD). MATERIALS AND METHODS: All primary studies which reported the factors associated with of RA-ILD were eligible for the review except case reports...
2023: PloS One
#16
JOURNAL ARTICLE
Jungyoon Choi, Tae Won Lee, Eunjin Bae, Ha Nee Jang, Hyo Jung An, Se-Ho Chang, Dong Jun Park
RATIONALE: Only 1 case of IgA nephropathy (IgAN) with minimal change disease (MCD) associated with primary Sjögren's syndrome (SS) has been reported. We additionally describe IgAN with MCD associated with primary SS. PATIENT CONCERNS: A 80-year-old woman visited our hospital complaining of generalized edema that had started 4 weeks prior. She reported a sense of thirst and dry eye for the last 5 years. DIAGNOSES: Her initial laboratory findings were compatible with nephrotic syndrome; both the antinuclear antibody (1:80) and anti-SS-A (Ro) antibody (200 U/mL) tests were positive...
June 2, 2023: Medicine (Baltimore)
#17
JOURNAL ARTICLE
May Yee Choi, Irene Chen, Ann Elaine Clarke, Marvin J Fritzler, Katherine A Buhler, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J Wallace, David Alan Isenberg, Anisur Rahman, Joan T Merrill, Paul R Fortin, Dafna D Gladman, Ian N Bruce, Michelle Petri, Ellen M Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jönsen, Graciela S Alarcón, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth Kalunian, Søren Jacobsen, Christine Peschken, Diane L Kamen, Anca Askanase, Jill P Buyon, David Sontag, Karen H Costenbader
OBJECTIVES: A novel longitudinal clustering technique was applied to comprehensive autoantibody data from a large, well-characterised, multinational inception systemic lupus erythematosus (SLE) cohort to determine profiles predictive of clinical outcomes. METHODS: Demographic, clinical and serological data from 805 patients with SLE obtained within 15 months of diagnosis and at 3-year and 5-year follow-up were included. For each visit, sera were assessed for 29 antinuclear antibodies (ANA) immunofluorescence patterns and 20 autoantibodies...
July 2023: Annals of the Rheumatic Diseases
#18
JOURNAL ARTICLE
I Dewa Gde Dwi Sumajaya, I Putu Hendri Aryadi, I Made Eryana
BACKGROUND: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that has a great diversity of clinical presentations and occurs mostly in young women. However, late-onset SLE does exist and seldom presents with an atypical case, including pericardial effusion (PE). CASE PRESENTATION: A 64 years old Asian woman presented with weakness all over the body and slight breathlessness for the past 2 days before the hospital admission. Her initial vital signs are 80/50 mmHg for blood pressure and a respiration rate of 24 breaths/min...
April 20, 2023: Egyptian Heart Journal: EHJ
#19
Yongmei Sun, Xuan Kan, Rongxiu Zheng, Liping Hao, Zongtao Mao, Ying Jia
OBJECTIVE: This study aims to summarize the clinical characteristics of one teenager with autoimmune polyglandular syndrome (APS) type III C + D to improve the understanding of APS III C + D and its effect of thyroid function. METHODS: This article reported the clinical manifestations, laboratory examinations, treatment methods, and outcomes of an adolescent with anemia admitted to the Pediatrics Department of Tianjin Medical University General Hospital in July 2020 and reviewed the literature...
2023: Frontiers in Pediatrics
#20
JOURNAL ARTICLE
Lihua Zhang, Mengru Du, Yuanmao Tu, Dandan Liang, Xiaomei Wu, Honglang Xie
OBJECTIVE: The pathological types and long-term prognosis of glomerular diseases related to mercury exposure are unclear. This study retrospectively examined 41 cases of glomerulonephropathy caused by mercury-containing cosmetics. METHODOLOGY: Forty-one subjects with glomerular diseases presumably caused by mercury-containing cosmetics were selected. Clinical features, kidney biopsy, treatment, and follow-up data were collected. RESULTS: All patients were female with an average age of 39...
April 15, 2023: Journal of Nephrology
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