keyword
https://read.qxmd.com/read/38536963/affinity-tagged-smad1-and-smad5-mouse-lines-reveal-transcriptional-reprogramming-mechanisms-during-early-pregnancy
#1
JOURNAL ARTICLE
Zian Liao, Suni Tang, Kaori Nozawa, Keisuke Shimada, Masahito Ikawa, Diana Monsivais, Martin Matzuk
Endometrial decidualization, a prerequisite for successful pregnancies, relies on transcriptional reprogramming driven by progesterone receptor (PR) and bone morphogenetic protein (BMP)-SMAD1/SMAD5 signaling pathways. Despite their critical roles in early pregnancy, how these pathways intersect in reprogramming the endometrium into a receptive state remains unclear. To define how SMAD1 and/or SMAD5 integrate BMP signaling in the uterus during early pregnancy, we generated two novel transgenic mouse lines with affinity tags inserted into the endogenous SMAD1 and SMAD5 loci ( Smad1HA/HA and Smad5PA/PA )...
March 27, 2024: ELife
https://read.qxmd.com/read/38536596/pathologic-maternal-and-neonatal-outcomes-associated-with-programmed-embryo-transfer-potential-etiologies-and-strategies-for-prevention
#2
REVIEW
Kirk P Conrad, Frauke von Versen-Höynck, Valerie L Baker
PURPOSE: In the first of two companion papers, we comprehensively reviewed the recent evidence in the primary literature, which addressed the increased prevalence of hypertensive disorders of pregnancy, late-onset or term preeclampsia, fetal overgrowth, postterm birth, and placenta accreta in women conceiving by in vitro fertilization. The preponderance of evidence implicated frozen embryo transfer cycles and, specifically, those employing programmed endometrial preparations, in the higher risk for these adverse maternal and neonatal pregnancy outcomes...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38536594/pathologic-maternal-and-neonatal-outcomes-associated-with-programmed-embryo-transfer
#3
REVIEW
Kirk P Conrad, Frauke von Versen-Höynck, Valerie L Baker
PURPOSE: In this first of two companion papers, we critically review the evidence recently published in the primary literature, which addresses adverse maternal and neonatal pregnancy outcomes associated with programmed embryo transfer cycles. We next consider whether these pathological pregnancy outcomes might be attributable to traditional risk factors, unknown parental factors, embryo culture, culture duration, or cryopreservation. Finally, in the second companion article, we explore potential etiologies and suggest strategies for prevention...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38534737/inhibition-of-nkcc1-ameliorates-anxiety-and-autistic-behaviors-induced-by-maternal-immune-activation-in-mice
#4
JOURNAL ARTICLE
Hai-Long Zhang, Shufen Hu, Shu-Ting Qu, Meng-Dan Lv, Jun-Jun Wang, Xin-Ting Liu, Jia-He Yao, Yi-Yan Ding, Guang-Yin Xu
Autism spectrum disorder (ASD) is thought to result from susceptibility genotypes and environmental risk factors. The offspring of women who experience pregnancy infection have an increased risk for autism. Maternal immune activation (MIA) in pregnant animals produces offspring with autistic behaviors, making MIA a useful model for autism. However, how MIA causes autistic behaviors in offspring is not fully understood. Here, we show that NKCC1 is critical for mediating autistic behaviors in MIA offspring. We confirmed that MIA induced by poly(I:C) infection during pregnancy leads to autistic behaviors in offspring...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534675/impact-of-genital-infections-and-antibiotic-use-on-incidence-of-preterm-birth-a-retrospective-observational-study
#5
JOURNAL ARTICLE
Daniela Teodora Marti, Felix Bratosin, Ovidiu Rosca, Roxana Folescu, Cosmin Citu, Adrian Ratiu, Zoran Laurentiu Popa
This study investigates the complex interplay among genital infections, antibiotic usage, and preterm birth. This study aims to identify common genital pathogens associated with preterm births, assess the impact of various antibiotic treatments on pregnancy outcomes, and understand antibiotic resistance patterns among these pathogens. This study included 71 pregnant women who experienced preterm birth and 94 women with genital infections who delivered at term. Various maternal characteristics, medical history, signs and symptoms, gestational weight, gestational age, type of birth, vaginal pH, Nugent scores, and vaginal flora were analyzed...
March 5, 2024: Antibiotics
https://read.qxmd.com/read/38534008/-there-is-nothing-to-protect-us-from-dying-black-women-s-perceived-sense-of-safety-accessing-pregnancy-and-intrapartum-care
#6
JOURNAL ARTICLE
Priscilla N Boakye, Nadia Prendergast
Pregnancy and childbirth have become a dangerous journey for Black women as harrowing stories of death and near-death experiences resonate within Black communities. While the causes of pregnancy-related morbidity and mortality are well documented, little is known about how Black Canadian women feel protected from undesirable maternal health outcomes when accessing and receiving pregnancy and intrapartum care. This critical qualitative inquiry sheds light on Black women's perceived sense of safety in accessing pregnancy and intrapartum care...
March 27, 2024: Nursing Inquiry
https://read.qxmd.com/read/38533906/social-determinants-associated-with-substance-use-and-treatment-seeking-in-females-of-reproductive-age-in-the-united-states
#7
JOURNAL ARTICLE
Holly Horan, Alyssa Thompson, Kendall Willard, Emmily Mobley, Justin McDaniel, Ellen Robertson, Shanna McIntosh, David L Albright
Introduction: Females of reproductive age (FoRA; 15-49 years) are the demographic most likely to be diagnosed with a substance use disorder. Preventative treatment prior to or during pregnancy is critical. Stigma and social inequities can delay access to care. There is limited research examining social determinants of health (SDoH) and how they are related to substance use and treatment seeking in this demographic. Methods: We analyzed the 2016-2019 data from the United States National Survey on Drug Use and Health using multivariable logistic regression models...
March 27, 2024: Journal of Women's Health
https://read.qxmd.com/read/38533532/assisted-reproductive-technology-art-is-not-an-independent-risk-factor-for-breech-presentation-among-singleton-term-births-in-vienna-austria
#8
JOURNAL ARTICLE
L Bartsch, M Hämmerle, S Putschögl, B Hartmann, S Kirchengast
Assisted reproductive technologies (ARTs) such as in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) are still discussed critically, as there is no consensus on whether these treatments could be the cause of risk factors for obstetric problems such as breech presentation. The aim of this study was to test the association between ART and breech presentation among 11920 singleton term births taking place in Vienna from 2010 to 2020. In this single-centre medical record-based study, data concerning the conception mode (spontaneous versus IVF or ICSI), child presentation, birth mode, newborn sex and size as well as age, height, weight, and reproductive history of the mother were included...
March 27, 2024: Journal of Biosocial Science
https://read.qxmd.com/read/38531705/review-phenotypic-and-molecular-evidence-of-inter-and-trans-generational-effects-of-heat-stress-in-livestock-mammals-and-humans
#9
REVIEW
J Laporta, H Khatib, M Zachut
Internal and external factors can change an individual's phenotype. A significant external threat to humans and livestock is environmental heat load, a combination of high ambient temperatures and humidity. A heat stress response occurs when an endothermal animal is exposed to a heat load that challenges its' thermoregulation capacity. With the ongoing climate change trends, the incidence of chronically elevated temperatures causing heat stress is expected to rise, posing an even greater risk to the health and survival of all species...
February 29, 2024: Animal
https://read.qxmd.com/read/38531505/residential-greenness-during-pregnancy-and-early-life-and-development-of-asthma-up-to-27-years-of-age-the-espoo-cohort-study
#10
JOURNAL ARTICLE
Aino K Rantala, Inês Paciência, Harri Antikainen, Jan Hjort, Timo T Hugg, Maritta S Jaakkola, Jouni J K Jaakkola
Previous studies have suggested that living close to green spaces has protective health effects, but potential effects on asthma are contradictory. We investigated the association between the amount of greenness in the residential area during pregnancy and early life and development of asthma in the first 27 years of life. The study population included all 2568 members of the Espoo Cohort Study, Finland. We calculated individual-level exposure to green space measured as cumulative Normalized Difference Vegetation Index (cumNDVI in unit-months) within 300 m of the participant's residence during pregnancy and the first two years of life in both spring and summer seasons...
March 24, 2024: Environmental Research
https://read.qxmd.com/read/38530386/-position-paper-on-working-in-the-intensive-care-unit-during-pregnancy-divi-recommendations-for-improving-the-situation-of-pregnant-employees-in-the-icu
#11
REVIEW
Celina Cornelius, Teresa Deffner, Aileen Hill, Christina Rohlfes, Bernd Ellner, Silke Klarmann, Sabine Riedel, Sabrina Pelz, Sabrina Kopp, Laura Borgstedt, Diana Freund, Andreas Schöpfel, Patrick Meybohm, Felix Walcher, Thorsten Brenner, Stefanie Klenke
The Maternity Protection Act is intended to protect the mother and the child from hazards, excessive demands and damage to health in the workplace, and from financial disadvantages and loss of employment. However, the objectives defined by the Maternity Protection Act-the safety and health of the pregnant employee on the one hand and the prevention of disadvantages in working life on the other-are not yet adequately achieved in the intensive care unit (ICU). Implementation of the Maternity Protection Act to the benefit of all involved parties should also be promoted in the specialist areas represented by the DIVI, in particular the work of pregnant physicians and nursing staff and other working specialists (respiratory therapists, physiotherapists, speech therapists, psychotherapists, and social workers) in the ICU...
March 26, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38529692/prenatal-and-postnatal-exposure-to-antibiotics-and-risk-of-food-allergy-in-the-offspring-a-nationwide-birth-cohort-study-in-south-korea
#12
JOURNAL ARTICLE
Jiyeon Oh, Myeongcheol Lee, Jaeyu Park, Hyeon Jin Kim, Seung Won Lee, Masoud Rahmati, Ai Koyanagi, Lee Smith, Min Seo Kim, Guillermo F López Sánchez, Elena Dragioti, Chanyang Min, Nikolaos G Papadopoulos, Youn Ho Shin, Jae Il Shin, Dong Keon Yon
BACKGROUND: There are only preliminary studies examining the associations of postnatal antibiotic exposure with food allergy in childhood, and the effect of antibiotic exposure in utero has not been resolved. Thus, we aimed to investigate the effect of prenatal and postnatal antibiotic exposure on the risk of food allergy in childhood. METHODS: Using the nationwide birth cohort in South Korea, all 3,163,206 infants (pairing mother; n = 2,322,735) born in South Korea between 2010 and 2017 were included in the analysis...
March 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38529439/eosinophilic-granulomatosis-with-polyangiitis-gradually-worsening-with-consecutive-pregnancies-a-case-report
#13
Ryuichi Ohta, Taichi Fujimori, Chiaki Sano
This case report elucidates the diagnosis and management of eosinophilic granulomatosis with polyangiitis (EGPA), a form of systemic vasculitis, in a 32-year-old female presenting with progressive dermal, respiratory, and gastrointestinal symptoms following multiple pregnancies. The patient's history of allergic reactions and pregnancies suggested a gradual progression of EGPA, a condition rarely associated with pregnancy. Initial symptoms were misinterpreted as allergic reactions and acute gastroenteritis, delaying the correct diagnosis...
February 2024: Curēus
https://read.qxmd.com/read/38529432/unveiling-the-role-of-endometrial-cd-138-a-comprehensive-review-on-its-significance-in-infertility-and-early-pregnancy
#14
REVIEW
Prachi A Ughade, Deepti Shrivastava
This review comprehensively examines the role of endometrial CD-138 (syndecan-1) in the context of infertility and early pregnancy. The endometrium, a dynamic tissue responsive to hormonal cues, plays a central role in fertility, and understanding the molecular intricacies governing its function is crucial. CD-138, a cell surface proteoglycan, emerges as a critical player expressed by various endometrial cell types. Our exploration encompasses a brief overview of the endometrium, introducing CD-138 as a significant molecular entity...
February 2024: Curēus
https://read.qxmd.com/read/38528557/factors-associated-with-antenatal-depression-among-women-attending-antenatal-care-at-mubende-regional-referral-hospital-a-cross-sectional-study
#15
JOURNAL ARTICLE
Musa Kasujja, Samuel Omara, Nasifu Senkungu, Shamim Ndibuuza, Joseph Kirabira, Usman Ibe, Lyse Barankunda
INTRODUCTION: This study aimed to investigate the prevalence, severity, and factors associated with antenatal depression among women receiving antenatal care at Mubende Regional Referral Hospital (MRRH) in Uganda. Antenatal depression is a critical concern for maternal and child well-being, as it is associated with adverse outcomes such as preterm birth, abortion, low birth weight, and impaired maternal-infant bonding. Despite several international guidelines recommending routine screening for antenatal depression, local Ugandan guidelines often overlook this essential aspect of maternal care...
March 25, 2024: BMC Women's Health
https://read.qxmd.com/read/38527602/the-association-between-discordant-umbilical-arterial-resistance-in-growth-restricted-fetuses-and-adverse-outcomes
#16
JOURNAL ARTICLE
Misgav Rottenstreich, Swati Agrawal, Homero Flores Mendoza, Sarah D McDonald, Bryon DeFrance, Jon Fr Barrett, Eran Ashwal
BACKGROUND: Assessing the umbilical artery pulsatility index (UA PI) via Doppler measurements plays a critical role in evaluating fetal growth impairment. This study aims to investigate perinatal outcomes associated with discordant PIs of umbilical arteries (UAs) in growth-restricted fetuses. METHODS: In this retrospective cohort study, all singleton pregnancies were included if their estimated fetal weight (EFW) and/or abdominal circumference (AC) fell below the 10th percentile for gestational age (2017-2022)...
March 23, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38526804/diabetic-disease-of-the-eye-in-canada-consensus-statements-from-a-retina-specialist-working-group
#17
JOURNAL ARTICLE
Amer Omar, R Geoff Williams, James Whelan, Jason Noble, Michael H Brent, Michel Giunta, Sébastien Olivier, Mustapha Lhor
Despite advances in systemic care, diabetic disease of the eye (DDE) remains the leading cause of blindness worldwide. There is a critical gap of up-to-date, evidence-based guidance for ophthalmologists in Canada that includes evidence from recent randomized controlled trials. Previous guidance has not always given special consideration to applying treatments and managing DDE in the context of the healthcare system. This consensus statement aims to assist practitioners in the field by providing a spectrum of acceptable opinions on DDE treatment and management from recognized experts in the field...
March 23, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38525579/community-perceptions-of-community-health-worker-effectiveness-contributions-to-health-behaviour-change-in-an-urban-health-district-in-south-africa
#18
JOURNAL ARTICLE
L S Thomas, Y Pillay, E Buch
BACKGROUND: Community health worker (CHW) programmes contribute towards strengthening adherence support, improving maternal and child health outcomes and providing support for social services. They play a valuable role in health behaviour change in vulnerable communities. Large-scale, comprehensive CHW programmes at health district level are part of a South African (SA) strategy to re-engineer primary healthcare and take health directly into communities and households, contributing to universal health coverage...
February 13, 2024: South African Medical Journal
https://read.qxmd.com/read/38525053/maternal-near-miss-hospitalizations-in-the-borana-zone-ethiopia-a-facility-based-longitudinal-cross-sectional-study
#19
JOURNAL ARTICLE
Boboh Kamangira, Gudeta Ayele, Polite Dube, Kaleb Melaku, Eubert Vushoma
BACKGROUND: Maternal near miss refers to a woman who nearly died but survived a complication that occurred during pregnancy, childbirth, or within 42 days of pregnancy termination. While there has been considerable progress in reducing maternal mortality rates, maternal near miss cases can provide valuable insights into the quality of maternal healthcare and help identify areas for improvement. However, there is limited evidence on the factors contributing to maternal near miss cases, including health system failures, delays in care, and provider-related factors...
January 2024: Journal of Public Health Research
https://read.qxmd.com/read/38523954/management-of-acute-saddle-pulmonary-embolism-in-pregnancy-following-fetal-surgery
#20
Patrick J Connell, Leonardo A Marquez Roa, Jorge Araujo-Duran, Monica Cheriyan, Sabry Ayad
A 33-year-old gravidity three parity three (G3P3) woman at 34 weeks of pregnancy underwent fetal surgery to repair an open lumbosacral myelomeningocele at 22 weeks gestation and experienced preterm premature rupture of membranes as a result. She developed a saddle pulmonary embolus with signs of right heart strain while on prolonged bed rest. She was treated emergently with aspiration thrombectomy and suprarenal inferior vena cava (IVC) filter placement, followed by an uncomplicated cesarean delivery thereafter...
February 2024: Curēus
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