keyword
https://read.qxmd.com/read/37830362/an-overview-of-metabolomic-and-proteomic-profiling-in-bipolar-disorder-and-its-clinical-value
#21
REVIEW
Henrique Caracho Ribeiro, Flávia da Silva Zandonadi, Alessandra Sussulini
INTRODUCTION: Bipolar disorder (BD) is a complex psychiatric disease characterized by alternating mood episodes. As for any other psychiatric illness, currently there is no biochemical test that is able to support diagnosis or therapeutic decisions for BD. In this context, the discovery and validation of biomarkers are interesting strategies that can be achieved through proteomics and metabolomics. AREAS COVERED: In this descriptive review, a literature search including original articles and systematic reviews published in the last decade was performed with the objective to discuss the results of BD proteomic and metabolomic profiling analyses and indicate proteins and metabolites (or metabolic pathways) with potential clinical value...
October 13, 2023: Expert Review of Proteomics
https://read.qxmd.com/read/37794663/identification-of-plasma-biomarkers-in-drug-na%C3%A3-ve-schizophrenia-using-targeted-metabolomics
#22
JOURNAL ARTICLE
Qiao Su, Fuyou Bi, Shu Yang, Huiming Yan, Xiaoxiao Sun, Jiayue Wang, Yuying Qiu, Meijuan Li, Shen Li, Jie Li
OBJECTIVE: Schizophrenia (SCZ) is a severe psychiatric disorder with unknown etiology and lacking specific biomarkers. Herein, we aimed to explore plasma biomarkers relevant to SCZ using targeted metabolomics. METHODS: Sixty drug-naïve SCZ patients and 36 healthy controls were recruited. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale. We analyzed the levels of 271 metabolites in plasma samples from all subjects using targeted metabolomics, and identified metabolites that differed significantly between the two groups...
September 2023: Psychiatry Investigation
https://read.qxmd.com/read/37790319/the-metabolome-wide-signature-of-major-depressive-disorder
#23
Rick Jansen, Yuri Milaneschi, Daniela Schranner, Gabi Kastenmüller, Matthias Arnold, Xianlin Han, Boadie Dunlop, A Rush, Rima Kaddurah-Daouk, Brenda Penninx
Major Depressive Disorder (MDD) is an often-chronic condition with substantial molecular alterations and pathway dysregulations involved. Single metabolite, pathway and targeted metabolomics platforms have indeed revealed several metabolic alterations in depression including energy metabolism, neurotransmission and lipid metabolism. More comprehensive coverage of the metabolome is needed to further specify metabolic dysregulation in depression and reveal previously untargeted mechanisms. Here we measured 820 metabolites using the metabolome-wide Metabolon platform in 2770 subjects from a large Dutch clinical cohort with extensive depression clinical phenotyping (1101 current MDD, 868 remitted MDD, 801 healthy controls) at baseline and 1805 subjects at 6-year follow up (327 current MDD, 1045 remitted MDD, 433 healthy controls)...
September 21, 2023: Research Square
https://read.qxmd.com/read/37755261/effects-of-exercise-on-functional-recovery-in-patients-with-bipolar-depression-a-study-protocol-for-a-randomized-controlled-trial
#24
JOURNAL ARTICLE
Fumito Hamada, Hikaru Hori, Hitoshi Iida, Hiroyuki Yokoyama, Hiroko Sugawara, Akito Hatanaka, Leo Gotoh, Muneaki Ogata, Hiroki Kumagai, Rika Yano, Yuko Tomiyama, Tetsuya Yoshida, Yoshimi Yamaguchi, Ryo Asada, Masato Masuda, Yuta Okamoto, Hiroaki Kawasaki
Treatment of bipolar disorder is prone to prolongation despite various treatments, including medication. The efficacy of exercise treatment (i.e., interventions involving physical exercise and sports intervention) for major depressive disorders has been reported for depressive symptoms, cognitive function, and sleep disturbances. However, its efficacy for bipolar disorder has yet to be established. We designed a randomized, controlled, double-blind clinical trial that includes 100 patients with bipolar disorder aged 20-65 years...
August 30, 2023: Metabolites
https://read.qxmd.com/read/37736060/search-for-serum-biomarkers-in-patients-with-bipolar-disorder-and-major-depressive-disorder-using-metabolome-analysis
#25
JOURNAL ARTICLE
Xiao-Li Sun, Li-Na Ma, Zhen-Zhu Chen, Yan-Bing Xiong, Jiao Jia, Yu Wang, Yan Ren
OBJECTIVE: Bipolar disorder (BD) and major depressive disorder (MDD) are two common psychiatric disorders. Due to the overlapping clinical symptoms and the lack of objective diagnostic biomarkers, bipolar disorder (BD) is easily misdiagnosed as major depressive disorder (MDD), which in turn affects treatment decisions and prognosis. This study aimed to investigate biomarkers that could be used to differentiate BD from MDD. METHODS: Nuclear magnetic resonance (NMR) spectroscopy was performed to assess serum metabolic profiles in depressed patients with BD ( n = 59), patients with MDD ( n = 14), and healthy controls ( n = 10)...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37730149/potential-csf-biomarkers-of-postpartum-depression-following-delivery-via-caesarian-section
#26
JOURNAL ARTICLE
Zhihao Sheng, Qidong Liu, Rong Lin, Yan Zhao, Weiqing Liu, Zhendong Xu, Zhiqiang Liu
BACKGROUND: Postpartum depression (PPD), the depressive episodes following delivery, is a serious and frequent psychiatric disorder. While numerous screening tools existed for depressive episodes, e.g., the Edinburgh Postnatal Depression Scale (EPDS), there are no objective biological measures for predicting PPD. Despite several studies done to identify biomarkers in PPD, there has been limited exploration into cerebrospinal fluid (CSF) which directly interfaces with the brain. Consequently, novel potential biomarkers of CSF are required to predict PPD, so as to target specific preventive interventions...
September 18, 2023: Journal of Affective Disorders
https://read.qxmd.com/read/37686207/metabolomics-perspectives-on-clinical-employment-in-autism-spectrum-disorder
#27
REVIEW
Martina Siracusano, Lucrezia Arturi, Assia Riccioni, Antonio Noto, Michele Mussap, Luigi Mazzone
Precision medicine is imminent, and metabolomics is one of the main actors on stage. We summarize and discuss the current literature on the clinical application of metabolomic techniques as a possible tool to improve early diagnosis of autism spectrum disorder (ASD), to define clinical phenotypes and to identify co-occurring medical conditions. A review of the current literature was carried out after PubMed, Medline and Google Scholar were consulted. A total of 37 articles published in the period 2010-2022 was included...
August 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37541332/overview-of-metabolomic-aspects-in-postpartum-depression
#28
JOURNAL ARTICLE
Marcela Konjevod, Martin Gredicak, Barbara Vuic, Lucija Tudor, Matea Nikolac Perkovic, Tina Milos, Dubravka Svob Strac, Nela Pivac, Gordana Nedic Erjavec
Along with the typical biochemical alterations that occur during pregnancy, certain metabolic changes might be associated with the development of several psychiatric disorders, including postpartum depression (PPD), which is the most common type of psychiatric disorder during pregnancy or first postpartum year, and it develops in about 15% of women. Metabolomics is a rapidly developing discipline that deals with the metabolites as the final products of all genetically controlled biochemical pathways, highly influenced by external and internal changes...
August 2, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/37530897/behavioral-metabolomics-how-behavioral-data-can-guide-metabolomics-research-on-neuropsychiatric-disorders
#29
JOURNAL ARTICLE
Ross van de Wetering, Jan A Vorster, Sophie Geyrhofer, Joanne E Harvey, Robert A Keyzers, Susan Schenk
INTRODUCTION: Metabolomics produces vast quantities of data but determining which metabolites are the most relevant to the disease or disorder of interest can be challenging. OBJECTIVES: This study sought to demonstrate how behavioral models of psychiatric disorders can be combined with metabolomics research to overcome this limitation. METHODS: We designed a preclinical, untargeted metabolomics procedure, that focuses on the determination of central metabolites relevant to substance use disorders that are (a) associated with changes in behavior produced by acute drug exposure and (b) impacted by repeated drug exposure...
August 2, 2023: Metabolomics: Official Journal of the Metabolomic Society
https://read.qxmd.com/read/37455357/succinic-semialdehyde-dehydrogenase-deficiency-in-mice-and-in-humans-an-untargeted-metabolomics-perspective
#30
REVIEW
Tessa M A Peters, Udo F H Engelke, Siebolt de Boer, Joris T G Reintjes, Jean-Baptiste Roullet, Sanne Broekman, Erik de Vrieze, Erwin van Wijk, Mirjam M C Wamelink, Rafael Artuch, Ivo Barić, Jona Merx, Thomas J Boltje, Jonathan Martens, Michèl A A P Willemsen, Marcel M Verbeek, Ron A Wevers, K Michael Gibson, Karlien L M Coene
Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a rare neurometabolic disorder caused by disruption of the gamma-aminobutyric acid (GABA) pathway. A more detailed understanding of its pathophysiology, beyond the accumulation of GABA and gamma-hydroxybutyric acid (GHB), will increase our understanding of the disease and may support novel therapy development. To this end, we compared biochemical body fluid profiles from SSADHD patients with controls using next-generation metabolic screening (NGMS)...
July 16, 2023: Journal of Inherited Metabolic Disease
https://read.qxmd.com/read/37451530/exploring-the-mechanisms-of-clozapine-induced-blood-brain-barrier-dysfunction-using-untargeted-metabolomics-and-cellular-metabolism-analysis
#31
JOURNAL ARTICLE
Surachai Ngamratanapaiboon, Napatarin Srikornvit, Patipol Hongthawonsiri, Krittaboon Pornchokchai, Siriphattarinya Wongpitoonmanachai, Petchlada Pholkla, Jiajun Mo, Pracha Yambangyang, Watcharaporn Devakul Na Ayutthaya
Brain microvascular endothelial cells (BMVECs) from the blood- brain barrier form a highly selective membrane that protects the brain from circulating blood and maintains a stable microenvironment for the central nervous system. BMVEC dysfunction has been implicated in a variety of neurological and psychiatric disorders. Clozapine, a widely used antipsychotics, has been demonstrated to alter the permeability of BMVECs, but the underlying mechanisms of this effect are not fully understood. In this study, we investigated the effects of clozapine in BMVECs using untargeted metabolomics analysis...
July 12, 2023: Environmental Toxicology and Pharmacology
https://read.qxmd.com/read/37409371/radiomics-a-potential-next-omics-in-psychiatric-disorders-an-introduction
#32
JOURNAL ARTICLE
Mohammadreza Alizadeh, Manoj Tanwar, Amir H Sarrami, Ramin Shahidi, Aparna Singhal, Houman Sotoudeh
Psychiatric disorders remain one of the most debilitating conditions; however, most patients are never diagnosed and do not seek treatment. Despite its massive burden on modern society and the health system, many hurdles prevent proper diagnosis and management of these disorders. The diagnosis is primarily based on clinical symptoms, and efforts to find appropriate biomarkers have not been practical. Through the past years, researchers have put a tremendous effort into finding biomarkers in "omics" fields: genomics, transcriptomics, proteomics, metabolomics, and epigenomics...
July 2023: Psychiatry Investigation
https://read.qxmd.com/read/37377643/fructus-gardeniae-ameliorates-anxiety-like-behaviors-induced-by-sleep-deprivation-via-regulating-hippocampal-metabolomics-and-gut-microbiota
#33
JOURNAL ARTICLE
Dong Liu, Qianfei Wang, Ying Li, Zhenshuang Yuan, Zhiliang Liu, Junli Guo, Xin Li, Weichao Zhang, Yulei Tao, Jianqiang Mei
Fructus gardeniae (FG) is a traditional Chinese medicine and health food for thousands of years of application throughout Chinese history and is still widely used in clinical Chinese medicine. FG has a beneficial impact on anxiety, depression, insomnia, and psychiatric disorders; however, its mechanism of action requires further investigation. This study aimed to investigate the effects and mechanisms of FG on sleep deprivation (SD)-induced anxiety-like behavior in rats. A model of SD-induced anxiety-like behavior in rats was established by intraperitoneal injection of p-chlorophenylalanine (PCPA)...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/37368949/the-impact-of-inflammatory-and-metabolic-markers-on-depression-anxiety-and-cognition-after-covid-19-a-narrative-review
#34
JOURNAL ARTICLE
Elton Jorge Bessa Diniz, Fulvio Alexandre Scorza, Fabrício Maués Santos Rodrigues, Claudia Berlim de Mello, Tatiana Carvalho de Souza Bonetti, Karina Ramalho Bortoluci, Jair de Jesus Mari
INTRODUCTION: There has been growing concern about the long-term effects of COVID-19 on mental health. The biological factors common to psychiatric conditions and COVID-19 are not yet fully understood. METHODOLOGY: We narratively reviewed prospective longitudinal studies that measured metabolic or inflammatory markers and assessed psychiatric sequalae and cognitive impairment in individuals with COVID-19 at least 3 months after the infection. A literature search identified three relevant cohort studies...
June 26, 2023: Trends in Psychiatry and Psychotherapy
https://read.qxmd.com/read/37308476/akt-and-mapk-signaling-pathways-in-hippocampus-reveals-the-pathogenesis-of-depression-in-four-stress-induced-models
#35
JOURNAL ARTICLE
Xuemei Li, Teng Teng, Wei Yan, Li Fan, Xueer Liu, Gerard Clarke, Dan Zhu, Yuanliang Jiang, Yajie Xiang, Ying Yu, Yuqing Zhang, Bangmin Yin, Lin Lu, Xinyu Zhou, Peng Xie
Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder. The pathogenesis of MDD remained unclear, and it may be associated with exposure to different stressors. Most previous studies have focused on molecular changes in a single stress-induced depression model, which limited the identification of the pathogenesis of MDD. The depressive-like behaviors were induced by four well-validated stress models in rats, including chronic unpredictable mild stress, learned helplessness stress, chronic restraint stress and social defeat stress...
June 12, 2023: Translational Psychiatry
https://read.qxmd.com/read/37239168/valproate-induced-metabolic-syndrome
#36
REVIEW
Natalia A Shnayder, Violetta V Grechkina, Vera V Trefilova, Ilya S Efremov, Evgenia A Dontceva, Ekaterina A Narodova, Marina M Petrova, Irina A Soloveva, Liia E Tepnadze, Polina A Reznichenko, Mustafa Al-Zamil, Gulnara I Altynbekova, Anna I Strelnik, Regina F Nasyrova
Valproic acid (VPA) and its salts (sodium calcium magnesium and orotic) are psychotropic drugs that are widely used in neurology and psychiatry. The long-term use of VPA increases the risk of developing adverse drug reactions (ADRs), among which metabolic syndrome (MetS) plays a special role. MetS belongs to a cluster of metabolic conditions such as abdominal obesity, high blood pressure, high blood glucose, high serum triglycerides, and low serum high-density lipoprotein. Valproate-induced MetS (VPA-MetS) is a common ADR that needs an updated multidisciplinary approach to its prevention and diagnosis...
May 22, 2023: Biomedicines
https://read.qxmd.com/read/37196634/molecular-signatures-of-post-traumatic-stress-disorder-in-war-zone-exposed-veteran-and-active-duty-soldiers
#37
JOURNAL ARTICLE
Seid Muhie, Aarti Gautam, Ruoting Yang, Burook Misganaw, Bernie J Daigle, Synthia H Mellon, Janine D Flory, Duna Abu-Amara, Inyoul Lee, Kai Wang, Ryan Rampersaud, Leroy Hood, Rachel Yehuda, Charles R Marmar, Owen M Wolkowitz, Kerry J Ressler, Francis J Doyle, Rasha Hammamieh, Marti Jett
Post-traumatic stress disorder (PTSD) is a multisystem syndrome. Integration of systems-level multi-modal datasets can provide a molecular understanding of PTSD. Proteomic, metabolomic, and epigenomic assays are conducted on blood samples of two cohorts of well-characterized PTSD cases and controls: 340 veterans and 180 active-duty soldiers. All participants had been deployed to Iraq and/or Afghanistan and exposed to military-service-related criterion A trauma. Molecular signatures are identified from a discovery cohort of 218 veterans (109/109 PTSD+/-)...
May 16, 2023: Cell reports medicine
https://read.qxmd.com/read/37166453/serine-metabolism-during-differentiation-of-human-ipsc-derived-astrocytes
#38
JOURNAL ARTICLE
Farida Tripodi, Zoraide Motta, Giulia Murtas, Valentina Rabattoni, Simona Nonnis, Francesca Grassi Scalvini, Anna Maria Rinaldi, Roberto Rizzi, Claudia Bearzi, Beatrice Badone, Silvia Sacchi, Gabriella Tedeschi, Elisa Maffioli, Paola Coccetti, Loredano Pollegioni
Astrocytes are essential players in development and functions, being particularly relevant as regulators of brain energy metabolism, ionic homeostasis, and synaptic transmission. They are also the major source of L-serine in the brain, which is synthesized from the glycolytic intermediate 3-phosphoglycerate through the phosphorylated pathway. L-serine is the precursor of the two main co-agonists of the N-methyl-D-aspartate receptor, glycine and D-serine. Strikingly, dysfunctions in both L- and D-serine metabolism are associated with neurological and psychiatric disorders...
May 11, 2023: FEBS Journal
https://read.qxmd.com/read/37152431/cfos-expression-in-the-prefrontal-cortex-correlates-with-altered-cerebral-metabolism-in-developing-germ-free-mice
#39
JOURNAL ARTICLE
Trinity Pate, Daniel C Anthony, Daniel E Radford-Smith
INTRODUCTION: The microbiota plays a critical role in modulating various aspects of host physiology, particularly through the microbiota-gut-brain (MGB) axis. However, the mechanisms that transduce and affect gut-to-brain communication are still not well understood. Recent studies have demonstrated that dysbiosis of the microbiome is associated with anxiety and depressive symptoms, which are common complications of metabolic syndrome. Germ-free (GF) animal models offer a valuable tool for studying the causal effects of microbiota on the host...
2023: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/37146496/plasma-metabolomics-and-network-pharmacology-identified-glutamate-glutamine-and-arginine-as-biomarkers-of-depression-under-shuganjieyu-capsule-treatment
#40
JOURNAL ARTICLE
Dan Wang, Yao Gao, Yaojun Li, Yu Zhao, Xinzhe Du, Xinrong Li, Yu Zhang, Sha Liu, Yong Xu
Depression is a psychiatric disorder and confers an enormous burden on society. Mild to moderate forms of depression (MMD) are particularly common. Our previous studies showed that the Shuganjieyu (SGJY) capsule might improve depressive and cognitive symptoms in patients with MMD. However, biomarkers evaluating the efficacy of SGJY and the underlying mechanism remains unclear. The aim of the present study was to discover efficacy biomarkers and explore the underlying mechanisms of SGJY as antidepression treatment...
April 25, 2023: Journal of Pharmaceutical and Biomedical Analysis
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