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Metabolomics psychiatric disorders

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https://www.readbyqxmd.com/read/27919695/metabolomics-identifies-perturbations-in-amino-acid-metabolism-in-the-prefrontal-cortex-of-the-learned-helplessness-rat-model-of-depression
#1
Xinyu Zhou, Lanxiang Liu, Yuqing Zhang, Juncai Pu, Lining Yang, Chanjuan Zhou, Shuai Yuan, Hanping Zhang, Peng Xie
Major depressive disorder is a serious psychiatric condition associated with high rates of suicide and is a leading cause of health burden worldwide. However, the underlying molecular mechanisms of major depression are still essentially unclear. In our study, a non-targeted gas chromatography-mass spectrometry-based metabolomics approach was used to investigate metabolic changes in the prefrontal cortex of the learned helplessness rat model of depression. Body-weight measurements and behavioral tests including the active escape test, sucrose preference test, forced swimming test, elevated plus-maze and open field test were used to assess changes in the behavioral spectrum after inescapable footshock stress...
December 2, 2016: Neuroscience
https://www.readbyqxmd.com/read/27731396/purine-and-pyrimidine-metabolism-convergent-evidence-on-chronic-antidepressant-treatment-response-in-mice-and-humans
#2
Dong Ik Park, Carine Dournes, Inge Sillaber, Manfred Uhr, John M Asara, Nils C Gassen, Theo Rein, Marcus Ising, Christian Webhofer, Michaela D Filiou, Marianne B Müller, Christoph W Turck
Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly used drugs for the treatment of psychiatric diseases including major depressive disorder (MDD). For unknown reasons a substantial number of patients do not show any improvement during or after SSRI treatment. We treated DBA/2J mice for 28 days with paroxetine and assessed their behavioral response with the forced swim test (FST). Paroxetine-treated long-time floating (PLF) and paroxetine-treated short-time floating (PSF) groups were stratified as proxies for drug non-responder and responder mice, respectively...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27606320/fluoxetine-treatment-rescues-energy-metabolism-pathway-alterations-in-a-posttraumatic-stress-disorder-mouse-model
#3
Chi-Ya Kao, Zhisong He, Kathrin Henes, John M Asara, Christian Webhofer, Michaela D Filiou, Philipp Khaitovich, Carsten T Wotjak, Christoph W Turck
Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder. Several studies have attempted to characterize molecular alterations associated with PTSD, but most findings were limited to the investigation of specific cellular markers in the periphery or defined brain regions. In the current study, we aimed to unravel affected molecular pathways/mechanisms in the fear circuitry associated with PTSD. We interrogated a foot shock-induced PTSD mouse model by integrating proteomics and metabolomics profiling data...
May 2016: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/27599184/targeted-metabolomic-pathway-analysis-and-validation-revealed-glutamatergic-disorder-in-the-prefrontal-cortex-among-the-chronic-social-defeat-stress-mice-model-of-depression
#4
Wei Wang, Hua Guo, Shu-Xiao Zhang, Juan Li, Ke Cheng, Shun-Jie Bai, De-Yu Yang, Hai-Yang Wang, Zi-Hong Liang, Li Liao, Lin Sun, Peng Xie
Major depressive disorder (MDD) is a severe psychiatric disease that has critically affected life quality for millions of people. Chronic stress is gradually recognized as a primary pathogenesis risk factor of MDD. Despite the remarkable progress in mechanism research, the pathogenesis mechanism of MDD is still not well understood. Therefore, we conducted a liquid chromatography-tandem mass spectrometry (LC-MS/MS) detection of 25 major metabolites of tryptophanic, GABAergic, and catecholaminergic pathways in the prefontal cortex (PFC) of mice in chronic social defeat stress (CSDS)...
October 7, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27412728/mitochondrial-oxidative-phosphorylation-system-oxphos-deficits-in-schizophrenia-possible-interactions-with-cellular-processes
#5
Oded Bergman, Dorit Ben-Shachar
Mitochondria are key players in the generation and regulation of cellular bioenergetics, producing the majority of adenosine triphosphate molecules by the oxidative phosphorylation system (OXPHOS). Linked to numerous signaling pathways and cellular functions, mitochondria, and OXPHOS in particular, are involved in neuronal development, connectivity, plasticity, and differentiation. Impairments in a variety of mitochondrial functions have been described in different general and psychiatric disorders, including schizophrenia (SCZ), a severe, chronic, debilitating illness that heavily affects the lives of patients and their families...
August 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/27114925/blood-metabolomics-analysis-identifies-abnormalities-in-the-citric-acid-cycle-urea-cycle-and-amino-acid-metabolism-in-bipolar-disorder
#6
Noriko Yoshimi, Takashi Futamura, Keiji Kakumoto, Alireza M Salehi, Carl M Sellgren, Jessica Holmén-Larsson, Joel Jakobsson, Erik Pålsson, Mikael Landén, Kenji Hashimoto
BACKGROUND: Bipolar disorder (BD) is a severe and debilitating psychiatric disorder. However, the precise biological basis remains unknown, hampering the search for novel biomarkers. We performed a metabolomics analysis to discover novel peripheral biomarkers for BD. METHODS: We quantified serum levels of 116 metabolites in mood-stabilized male BD patients (n = 54) and age-matched male healthy controls (n = 39). RESULTS: After multivariate logistic regression, serum levels of pyruvate, N-acetylglutamic acid, α-ketoglutarate, and arginine were significantly higher in BD patients than in healthy controls...
June 2016: BBA Clinical
https://www.readbyqxmd.com/read/26947756/the-identification-of-metabolic-disturbances-in-the-prefrontal-cortex-of-the-chronic-restraint-stress-rat-model-of-depression
#7
Lanxiang Liu, Xinyu Zhou, Yuqing Zhang, Yiyun Liu, Lining Yang, Juncai Pu, Dan Zhu, Chanjuan Zhou, Peng Xie
Major depressive disorder, with serious impairment in cognitive and social functioning, is a complex psychiatric disorder characterized by pervasive and persistent low mood and a loss of interest or pleasure. However, the underlying molecular mechanisms of depression remain largely unknown. In this study, we used a non-targeted metabolomics approach based on gas chromatography-mass spectrometry of the prefrontal cortex in chronic restraint stress (CRS)-treated rats. CRS was induced in the stress group by restraining rats in a plastic restrainer for 6h every day...
May 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26913573/discovery-of-biochemical-biomarkers-for-aggression-a-role-for-metabolomics-in-psychiatry
#8
REVIEW
Fiona A Hagenbeek, Cornelis Kluft, Thomas Hankemeier, Meike Bartels, Harmen H M Draisma, Christel M Middeldorp, Ruud Berger, Antonio Noto, Milena Lussu, René Pool, Vassilios Fanos, Dorret I Boomsma
Human aggression encompasses a wide range of behaviors and is related to many psychiatric disorders. We introduce the different classification systems of aggression and related disorders as a basis for discussing biochemical biomarkers and then present an overview of studies in humans (published between 1990 and 2015) that reported statistically significant associations of biochemical biomarkers with aggression, DSM-IV disorders involving aggression, and their subtypes. The markers are of different types, including inflammation markers, neurotransmitters, lipoproteins, and hormones from various classes...
July 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/26874244/metabolite-signature-for-diagnosing-major-depressive-disorder-in-peripheral-blood-mononuclear-cells
#9
Peng Zheng, Zheng Fang, Xue-Jiao Xu, Mei-Ling Liu, Xiangyu Du, Xiaotong Zhang, Haiyang Wang, Jingjing Zhou, Peng Xie
BACKGROUND: Major depressive disorder (MDD) is a serious debilitating psychiatric disorder. However, the molecular mechanisms of MDD remain largely unknown, and no objective laboratory-based tests are available to diagnose this disorder. METHODS: A gas chromatography-mass spectrometry (GC-MS) based metabolomic approach was used to compare peripheral blood mononuclear cells (PBMC) metabolic profiling of 50 first onset drug-naïve MDD subjects and 50 healthy controls (training samples), to identify potential metabolite biomarkers for MDD...
May 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26727422/a-dysbiotic-subpopulation-of-alcohol-dependent-subjects
#10
Philippe de Timary, Sophie Leclercq, Peter Stärkel, Nathalie Delzenne
The vast majority of studies that assessed the importance of biological factors for the development of psychiatric disorders focused on processes occurring at the brain level. Alcohol-dependence is a very frequent psychiatric disorder where psycho-pharmacological interventions are only of moderate efficacy. Our laboratory has recently described that a subpopulation of alcohol-dependent subjects, that accounted for approximately 40% of individuals tested, presented with an increased intestinal permeability, with a dysbiosis, with alterations in the metabolomic content of faeces--that could play a role in the increased permeability--and finally with a more severe profile of alcohol-dependence than the other non-dysbiotic subpopulation...
2015: Gut Microbes
https://www.readbyqxmd.com/read/26721951/making-sense-of-blood-based-proteomics-and-metabolomics-in-psychiatric-research
#11
Paul C Guest, Francesca L Guest, Daniel Martins-de Souza
This manuscript describes the basics of proteomic and metabolic profiling of blood serum and plasma from patients with psychiatric disorders. It will also explain the rationale behind the use of these bodily fluids, due to the need for user-friendly and rapid tests in clinics with simple sampling procedures. It has become evident over the last 15 years or so that psychiatric disorders are whole-body diseases and the bloodstream is a means of molecular transport that therefore provides a conduit for two-way communication with the brain...
December 30, 2015: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26648521/long-term-neural-and-physiological-phenotyping-of-a-single-human
#12
Russell A Poldrack, Timothy O Laumann, Oluwasanmi Koyejo, Brenda Gregory, Ashleigh Hover, Mei-Yen Chen, Krzysztof J Gorgolewski, Jeffrey Luci, Sung Jun Joo, Ryan L Boyd, Scott Hunicke-Smith, Zack Booth Simpson, Thomas Caven, Vanessa Sochat, James M Shine, Evan Gordon, Abraham Z Snyder, Babatunde Adeyemo, Steven E Petersen, David C Glahn, D Reese Mckay, Joanne E Curran, Harald H H Göring, Melanie A Carless, John Blangero, Robert Dougherty, Alexander Leemans, Daniel A Handwerker, Laurie Frick, Edward M Marcotte, Jeanette A Mumford
Psychiatric disorders are characterized by major fluctuations in psychological function over the course of weeks and months, but the dynamic characteristics of brain function over this timescale in healthy individuals are unknown. Here, as a proof of concept to address this question, we present the MyConnectome project. An intensive phenome-wide assessment of a single human was performed over a period of 18 months, including functional and structural brain connectivity using magnetic resonance imaging, psychological function and physical health, gene expression and metabolomics...
December 9, 2015: Nature Communications
https://www.readbyqxmd.com/read/26453695/omics-based-biomarkers-application-of-metabolomics-in-neuropsychiatric-disorders
#13
REVIEW
Sumit Sethi, Elisa Brietzke
One of the major concerns of modern society is to identify putative biomarkers that serve as a valuable early diagnostic tool to identify a subset of patients with increased risk to develop neuropsychiatric disorders. Biomarker identification in neuropsychiatric disorders is proposed to offer a number of important benefits to patient well-being, including prediction of forthcoming disease, diagnostic precision, and a level of disease description that would guide treatment choice. Nowadays, the metabolomics approach has unlocked new possibilities in diagnostics of devastating disorders like neuropsychiatric disorders...
October 9, 2015: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26082563/biomarkers-in-mood-disorders-research-developing-new-and-improved-therapeutics
#14
Mark J Niciu, Daniel C Mathews, Dawn F Ionescu, Erica M Richards, Maura L Furey, Peixiong Yuan, Allison C Nugent, Ioline D Henter, Rodrigo Machado-Vieira, Carlos A Zarate
BACKGROUND: Recently, surrogate neurobiological biomarkers that correlate with target engagement and therapeutic response have been developed and tested in early phase studies of mood disorders. OBJECTIVE: The identification of biomarkers could help develop personalized psychiatric treatments that may impact public health. METHODS: These biomarkers, which are associated with clinical response post-treatment, can be directly validated using multimodal approaches including genetic tools, proteomics/metabolomics, peripheral measures, neuroimaging, biostatistical predictors, and clinical predictors...
2014: Revista de Psiquiatria Clínica
https://www.readbyqxmd.com/read/25826115/behavioural-and-molecular-endophenotypes-in-psychotic-disorders-reveal-heritable-abnormalities-in-glutamatergic-neurotransmission
#15
L Scoriels, R M Salek, E Goodby, D Grainger, A M Dean, J A West, J L Griffin, J Suckling, P J Nathan, B R Lennox, G K Murray, E T Bullmore, P B Jones
Psychotic disorders such as schizophrenia are biologically complex and carry huge population morbidity due to their prevalence, persistence and associated disability. Defined by features such as delusions and hallucinations, they involve cognitive dysfunction and neurotransmitter dysregulations that appear mostly to involve the dopaminergic and glutamatergic systems. A number of genetic and environmental factors are associated with these disorders but it has been difficult to identify the biological pathways underlying the principal symptoms...
March 31, 2015: Translational Psychiatry
https://www.readbyqxmd.com/read/25629821/acute-and-chronic-plasma-metabolomic-and-liver-transcriptomic-stress-effects-in-a-mouse-model-with-features-of-post-traumatic-stress-disorder
#16
Aarti Gautam, Peter D'Arpa, Duncan E Donohue, Seid Muhie, Nabarun Chakraborty, Brian T Luke, Dmitry Grapov, Erica E Carroll, James L Meyerhoff, Rasha Hammamieh, Marti Jett
Acute responses to intense stressors can give rise to post-traumatic stress disorder (PTSD). PTSD diagnostic criteria include trauma exposure history and self-reported symptoms. Individuals who meet PTSD diagnostic criteria often meet criteria for additional psychiatric diagnoses. Biomarkers promise to contribute to reliable phenotypes of PTSD and comorbidities by linking biological system alterations to behavioral symptoms. Here we have analyzed unbiased plasma metabolomics and other stress effects in a mouse model with behavioral features of PTSD...
2015: PloS One
https://www.readbyqxmd.com/read/25448502/dynamic-analysis-of-the-endogenous-metabolites-in-depressed-patients-treated-with-tcm-formula-xiaoyaosan-using-urinary-1-h-nmr-based-metabolomics
#17
Jun-sheng Tian, Guo-jiang Peng, Xiao-xia Gao, Yu-zhi Zhou, Jie Xing, Xue-mei Qin, Guan-hua Du
ETHNOPHAMACOLOGICAL RELEVANCE: Xiaoyaosan (XYS), one of the best-known traditional Chinese medicine prescriptions with a long history of use, is composed of Bupleurum chinense DC., Paeonia lactiflora Pall., Poria cocos (Schw.) Wolf, Angelica sinensis (Oliv.) Diels, Zingiber officinale Rosc., Atractylodes macrocephala Koidz., Glycyrrhiza uralensis Fisch., and Mentha haplocalyx Briq. For centuries, XYS has been widely used in China for the treatment of mental disorders such as depression...
December 2, 2014: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25288760/intestinal-permeability-gut-bacterial-dysbiosis-and-behavioral-markers-of-alcohol-dependence-severity
#18
Sophie Leclercq, Sébastien Matamoros, Patrice D Cani, Audrey M Neyrinck, François Jamar, Peter Stärkel, Karen Windey, Valentina Tremaroli, Fredrik Bäckhed, Kristin Verbeke, Philippe de Timary, Nathalie M Delzenne
Alcohol dependence has traditionally been considered a brain disorder. Alteration in the composition of the gut microbiota has recently been shown to be present in psychiatric disorders, which suggests the possibility of gut-to-brain interactions in the development of alcohol dependence. The aim of the present study was to explore whether changes in gut permeability are linked to gut-microbiota composition and activity in alcohol-dependent subjects. We also investigated whether gut dysfunction is associated with the psychological symptoms of alcohol dependence...
October 21, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/24953860/dietary-intake-and-plasma-metabolomic-analysis-of-polyunsaturated-fatty-acids-in-bipolar-subjects-reveal-dysregulation-of-linoleic-acid-metabolism
#19
Simon J Evans, Rachel N Ringrose, Gloria J Harrington, Peter Mancuso, Charles F Burant, Melvin G McInnis
Polyunsaturated fatty acids (PUFA) profiles associate with risk for mood disorders. This poses the hypothesis of metabolic differences between patients and unaffected healthy controls that relate to the primary illness or are secondary to medication use or dietary intake. However, dietary manipulation or supplementation studies show equivocal results improving mental health outcomes. This study investigates dietary patterns and metabolic profiles relevant to PUFA metabolism, in bipolar I individuals compared to non-psychiatric controls...
October 2014: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/24355550/selection-and-dynamic-metabolic-response-of-rat-biomarkers-by-metabonomics-and-multivariate-statistical-analysis-combined-with-gc-ms
#20
Xiaoxia Gao, Bingrong Guo, Lan Yang, Jiali Liu, Xiaoqin Zhang, Xuemei Qin, Guanhua Du
Depression is a common complex psychiatric disorder but its pathophysiological mechanism is not yet fully understood. Metabonomics by GC-MS and multivariate statistical analysis were used to select potential biomarkers associated with CUMS (chronic unpredictable mild stress) depression. The dynamic metabolic changes in rat serum were investigated to find potential disease biomarkers and to investigate the pathology of depression induced by the CUMS depression model. The changes in behavior and serum metabolic profiles were investigated during a three-week CUMS exposure...
February 2014: Pharmacology, Biochemistry, and Behavior
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