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Inflammatory mechanisms depression

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https://www.readbyqxmd.com/read/28633757/the-relationship-between-circulating-mitochondrial-dna-and-inflammatory-cytokines-in-patients-with-major-depression
#1
Yuki Kageyama, Takaoki Kasahara, Masaki Kato, Shiho Sakai, Yasuhiko Deguchi, Munehide Tani, Kenji Kuroda, Kotaro Hattori, Sumiko Yoshida, Yuichi Goto, Toshihiko Kinoshita, Koki Inoue, Tadafumi Kato
BACKGROUND: Although inflammatory cytokines are established biomarkers of mood disorders, their molecular mechanism is not known. We hypothesized that circulating mitochondrial DNA (mtDNA) contributes to inflammation and could be used as biomarkers. We investigated if circulating mtDNA level is associated with inflammatory cytokines and can be used as a biomarker of mood disorders. METHODS: Plasma mtDNA concentration was measured with real-time quantitative PCR targeting two regions of the mtDNA and plasma levels of four cytokines (GM-CSF, IL-2, IL-4, and IL-6) were measured with a multiplex immunoassay method in 109 patients with major depressive disorder (MDD)...
June 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28632121/anti-inflammatory-treatment-and-risk-for-depression-after-first-time-stroke-in-a-cohort-of-147-487-danish-patients
#2
Ida Kim Wium-Andersen, Marie Kim Wium-Andersen, Martin Balslev Jørgensen, Merete Osler
BACKGROUND: Depression is a common complication after stroke, and inflammation may be a pathophysiological mechanism. This study examines whether anti-inflammatory treatment with acetylsalicylic acid (ASA), nonsteroid anti-inflammatory drugs (NSAID) or statins influence the risk of depression after stroke. METHODS: A register-based cohort including all patients admitted to hospital with a first-time stroke from Jan. 1, 2001, through Dec. 31, 2011, and a nonstroke population with a similar age and sex distribution was followed for depression until Dec...
June 20, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28631232/activation-of-brain-indoleamine-2-3-dioxygenase-contributes-to-depressive-like-behavior-induced-by-an-intracerebroventricular-injection-of-streptozotocin-in-mice
#3
Leandro Cattelan Souza, Cristiano R Jesse, Marcelo Gomes de Gomes, Lucian Del Fabbro, André Tiago Rossito Goes, Franciele Donato, Silvana Peterini Boeira
There is a lack of information concerning the molecular events underlying the depressive-like effect of an intracerebroventricular injection of streptozotocin (ICV-STZ) in mice. The elevated activity of the tryptophan-degrading enzyme indoleamine-2,3-dioxygenase (IDO) has been proposed to mediate depression in inflammatory disorders. In the present study, we reported that ICV-STZ activates IDO in the hippocampus of mice and culminates in depressive-like behaviors, as measured by the increased duration of immobility in the tail suspension test and decreased sucrose intake in the sucrose preference test...
June 19, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28620379/neuroimmune-interactions-in-schizophrenia-focus-on-vagus-nerve-stimulation-and-activation-of-the-alpha-7-nicotinic-acetylcholine-receptor
#4
REVIEW
Fabiana Maria das Graças Corsi-Zuelli, Fernanda Brognara, Gustavo Fernando da Silva Quirino, Carlos Hiroji Hiroki, Rafael Sobrano Fais, Cristina Marta Del-Ben, Luis Ulloa, Helio Cesar Salgado, Alexandre Kanashiro, Camila Marcelino Loureiro
Schizophrenia is one of the most debilitating mental disorders and is aggravated by the lack of efficacious treatment. Although its etiology is unclear, epidemiological studies indicate that infection and inflammation during development induces behavioral, morphological, neurochemical, and cognitive impairments, increasing the risk of developing schizophrenia. The inflammatory hypothesis of schizophrenia is also supported by clinical studies demonstrating systemic inflammation and microglia activation in schizophrenic patients...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28608235/ferulic-acid-supplementation-for-management-of-depression-in-epilepsy
#5
Tanveer Singh, Taranjot Kaur, Rajesh Kumar Goel
Neuroinflammation driven altered neurochemical milieu have been reported to play a significant role in pathogenesis of comorbid depression in epilepsy. Most of the antiepileptic drugs (AEDs) such as levetiracetam, taigabine, topiramate have not been reported any significant effect in alleviating neuroinflammation, which may explain their ineffectiveness in ameliorating depression associated with epilepsy. The supplementation of antidepressants (ADs) attracts various pharmacokinetic and pharmacodynamic interactions with AEDs and was considered unsafe in epilepsy...
June 12, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28604559/wellbeing-and-arthritis-incidence-the-role-of-inflammatory-mechanisms-findings-from-the-english-longitudinal-study-of-ageing
#6
Judith A Okely, Alexander Weiss, Catharine R Gale
OBJECTIVE: Higher wellbeing is associated with lower levels of inflammatory markers in healthy populations; however, it is unclear whether this association translates into a reduced risk of disease. In the current study, we tested whether the association between wellbeing and inflammation results in a lower risk of arthritis. METHODS: The sample consisted of 5,622 participants aged ≥ 50 from the English Longitudinal Study of Ageing and included 6 waves of data collection...
June 10, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28595081/pioglitazone-attenuates-lipopolysaccharide-induced-depression-like-behaviors-modulates-nf-%C3%AE%C2%BAb-il-6-stat3-creb-bdnf-pathways-and-central-serotonergic-neurotransmission-in-mice
#7
L Liao, X D Zhang, J Li, Z W Zhang, C C Yang, C L Rao, C J Zhou, L Zeng, L B Zhao, L Fang, D Y Yang, P Xie
Immune activation and inflammation are closely associated with the development of depression. Pioglitazone (PIO), a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, has exhibited antidepressant-like effects in a couple of studies. However, the underlying mechanisms are far from being fully elucidated. The study aimed to investigate the effects of PIO on depression-like behaviors induced by lipopolysaccharide (LPS) and to explore the possible underlying mechanisms. The results showed that PIO pretreatment attenuated the depression-like behaviors in mice challenged with intracerebroventricular (i...
June 5, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28575809/lutein-mitigates-cyclophosphamide-induced-lung-and-liver-injury-via-nf-%C3%AE%C2%BAb-mapk-dependent-mechanism
#8
Amal A El-Kholy, Mohamed A Elkablawy, Dina S El-Agamy
This study targeted to test the potential protective role of lutein against lung and liver damage associated with cyclophosphamide (CP) administration. Lutein was given orally for 5days at two different doses both before and after CP injection. Results have shown that CP administration caused marked pulmonary and hepatic injurious effects in mice. Lung damage was evident through increased lung wet/dry ratio, elevated inflammatory cells infiltration into the pulmonary tissues, increased total protein content and lactate dehydrogenase (LDH) activity in the broncho-alveolar lavage fluid...
May 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28560656/social-well-being-is-associated-with-less-pro-inflammatory-and-pro-metastatic-leukocyte-gene-expression-in-women-after-surgery-for-breast-cancer
#9
Devika R Jutagir, Bonnie B Blomberg, Charles S Carver, Suzanne C Lechner, Kiara R Timpano, Laura C Bouchard, Lisa M Gudenkauf, Jamie M Jacobs, Alain Diaz, Susan K Lutgendorf, Steve W Cole, Aaron S Heller, Michael H Antoni
PURPOSE: Satisfaction with social resources, or "social well-being," relates to better adaptation and longer survival after breast cancer diagnosis. Biobehavioral mechanisms linking social well-being (SWB) to mental and physical health may involve inflammatory signaling. We tested whether reports of greater SWB were associated with lower levels of pro-inflammatory and pro-metastatic leukocyte gene expression after surgery for non-metastatic breast cancer. METHODS: Women (N = 50) diagnosed with non-metastatic (0-III) breast cancer were enrolled 2-8 weeks after surgery...
May 30, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28552058/potential-of-sulphur-containing-amino-acids-in-the-prevention-of-catecholamine-induced-arrhythmias
#10
Adriana Adameova, Paramjit S Tappia, Robert Hatala, Naranjan S Dhalla
BACKGROUND: Various physiological and pathological stimuli can hypersensitize the sympathetic nervous system resulting in a substantial release of catecholamines (CA) and consequent alterations in excitation-contraction coupling and excitation-transcription coupling. OBSERVATIONS: It has been shown that oxidation products of CA, rather than CA themselves, are responsible for such adaptation to a new equilibrium. While chronic, sustained accumulation of CA and their toxic products are associated with the depression in cardiac contractile force and remodeling, acute excessive release of CA can result in brief oxidative bursts and serious damage leading in lethal arrhythmias...
May 26, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28542024/omega-6-omega-3-pufa-ratio-pain-functioning-and-distress-in-adults-with-knee-pain
#11
Kimberly T Sibille, Christopher King, Timothy J Garrett, Toni L Glover, Hang Zhang, Huaihou Chen, Divya Reddy, Burel R Goodin, Adriana Sotolongo, Megan E Petrov, Yenisel Cruz-Almeida, Matthew Herbert, Emily J Bartley, Jeffrey C Edberg, Roland Staud, David T Redden, Laurence A Bradley, Roger B Fillingim
OBJECTIVES: Osteoarthritis (OA) is associated with inflammation, chronic pain, functional limitations, and psychosocial distress. High Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are associated with lower levels of inflammatory mediators, anti-nociception, and adaptive cognitive/emotional functioning. High Omega-6 (n-6) PUFAs are associated with inflammation, nociception, and psychological distress. While findings related to n-3 supplementation in knee OA are mixed, consideration of the n-6:n-3 ratio and additional outcome measures may provide improved understanding of the potential relevance of these fatty acids in OA...
May 24, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28539244/manganese-exposure-induces-neuroinflammation-by-impairing-mitochondrial-dynamics-in-astrocytes
#12
Souvarish Sarkar, Emir Malovic, Dilshan S Harischandra, Hilary A Ngwa, Anamitra Ghosh, Colleen Hogan, Dharmin Rokad, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Anumantha G Kanthasamy, Arthi Kanthasamy
Chronic manganese (Mn) exposure induces neurotoxicity, which is characterized by Parkinsonian symptoms resulting from impairment in the extrapyramidal motor system of the basal ganglia. Mitochondrial dysfunction and oxidative stress are considered key pathophysiological features of Mn neurotoxicity. Recent evidence suggests astrocytes as a major target of Mn neurotoxicity since Mn accumulates predominantly in astrocytes. However, the primary mechanisms underlying Mn-induced astroglial dysfunction and its role in metal neurotoxicity are not completely understood...
May 21, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28536068/polyunsaturated-fatty-acids-and-inflammatory-markers-in-major-depressive-episodes-during-pregnancy
#13
Jane Pei-Chen Chang, Chih-Ying Lin, Pan-Yen Lin, Yin-Hua Shih, Tsan-Hung Chiu, Ming Ho, Hui-Ting Yang, Shih-Yih Huang, Piotr Gałecki, Kuan-Pin Su
INTRODUCTION: Prenatal depression (PND) is a common psychiatric disorder in pregnant women and leads to psychosocial dysfunction, high suicidal rate, and adverse childcare. Patients with PND have omega-3 polyunsaturated fatty acid (omega-3 or n-3 PUFAs) deficits, which might link to chronic low-grade inflammatory process and the pathophysiological mechanisms of depression. In this case-control study, we examined the levels of PUFAs and inflammatory cytokines in PND. METHOD: Blood samples were obtained and analyzed from 16 healthy controls and 17 depressed cases (PND group) diagnosed with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)...
May 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28530434/associations-between-observed-parenting-behavior-and-adolescent-inflammation-two-and-a-half-years-later-in-a-community-sample
#14
Michelle L Byrne, Sally Horne, Neil M O'Brien-Simpson, Katrina A Walsh, Eric C Reynolds, Orli S Schwartz, Sarah Whittle, Julian G Simmons, Lisa Sheeber, Nicholas B Allen
OBJECTIVE: Family environments have an effect on physical health during adolescence, and a possible underlying mechanism is inflammation. However, little is known about the association between observed parenting behaviors and immune system functioning. The current study examined whether positive and negative emotional parental behaviors observed during family interactions were associated with inflammation in adolescents. METHOD: Sixty-one parent-adolescent dyads (37 male adolescents, 60...
May 22, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28529072/rescue-of-il-1%C3%AE-induced-reduction-of-human-neurogenesis-by-omega-3-fatty-acids-and-antidepressants
#15
Alessandra Borsini, Silvia Alboni, Mark A Horowitz, Luis M Tojo, Giuseppe Cannazza, Kuan-Pin Su, Carmine M Pariante, Patricia A Zunszain
Both increased inflammation and reduced neurogenesis have been associated with the pathophysiology of major depression. We have previously described how interleukin-1 (IL-1) β, a pro-inflammatory cytokine increased in depressed patients, decreases neurogenesis in human hippocampal progenitor cells. Here, using the same human in vitro model, we show how omega-3 (ω-3) polyunsaturated fatty acids and conventional antidepressants reverse this reduction in neurogenesis, while differentially affecting the kynurenine pathway...
May 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28495610/-allergic-mood-depressive-and-anxiety-symptoms-in-patients-with-seasonal-allergic-rhinitis-sar-and-their-association-to-inflammatory-endocrine-and-allergic-markers
#16
Katharina Trikojat, Hella Luksch, Angela Rösen-Wolff, Franziska Plessow, Jochen Schmitt, Angelika Buske-Kirschbaum
A growing number of studies show an association between seasonal allergic rhinitis (SAR) with depression and anxiety. The underlying mechanisms of a link between SAR and affect, however, are still unclear. The objective of the present study was to investigate depressive symptoms and anxiety in SAR patients and their association to inflammatory and endocrine parameters. SAR patients (n=41) and non-allergic, healthy controls (n=42) were assessed during (pollen season) and out of symptomatic periods (non-pollen season)...
May 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28493226/-etiology-and-pathophysiology-of-fibromyalgia-syndrome-updated-guidelines-2017-overview-of-systematic-review-articles-and-overview-of-studies-on-small-fiber-neuropathy-in-fms-subgroups
#17
N Üçeyler, M Burgmer, E Friedel, W Greiner, F Petzke, M Sarholz, M Schiltenwolf, A Winkelmann, C Sommer, W Häuser
BACKGROUND: The regular update of the guidelines on fibromyalgia syndrome, AWMF number 145/004, was planned for April 2017. METHODS: The guidelines were developed by 13 scientific societies and 2 patient self-help organizations coordinated by the German Pain Society. Working groups (n =8) with a total of 42 members were formed balanced with respect to gender, medical expertise, position in the medical or scientific hierarchy and potential conflicts of interest...
May 10, 2017: Der Schmerz
https://www.readbyqxmd.com/read/28479211/why-are-depressed-patients-inflamed-a-reflection-on-20-years-of-research-on-depression-glucocorticoid-resistance-and-inflammation
#18
REVIEW
Carmine M Pariante
Studies over the last 20 years have demonstrated that increased inflammation and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis are two of the most consistent biological findings in major depression and are often associated: but the molecular and clinical mechanisms underlying these abnormalities are still unclear. These findings are particularly enigmatic, especially considering the accepted notion that high levels of cortisol have an anti-inflammatory action, and therefore the coexistence of inflammation and hypercortisolemia in the same diagnostic group appears counter-intuitive...
May 4, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28474231/fluoxetine-reverses-behavior-changes-in-socially-isolated-rats-role-of-the-hippocampal-gsh-dependent-defense-system-and-proinflammatory-cytokines
#19
Ivana Perić, Andrijana Stanisavljević, Peter Gass, Dragana Filipović
Exposure of an organism to chronic social isolation (CSIS) has been shown to have an important role in depression. Fluoxetine (Flx) is a first-line treatment for depression; however, its downstream mechanisms of action beyond serotonergic signaling remain ill-defined. We investigated the effect of 3 weeks of Flx (15 mg/kg/day) treatment on behavioral changes and protein expression/activity of the GSH-dependent defense system, including reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GLR), and glutathione S-transferase (GST), as well as catalase (CAT), in the hippocampus of rats exposed to 6 weeks of CSIS...
May 4, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28468634/kososan-a-kampo-medicine-prevents-a-social-avoidance-behavior-and-attenuates-neuroinflammation-in-socially-defeated-mice
#20
Naoki Ito, Eiji Hirose, Tatsuya Ishida, Atsushi Hori, Takayuki Nagai, Yoshinori Kobayashi, Hiroaki Kiyohara, Tetsuro Oikawa, Toshihiko Hanawa, Hiroshi Odaguchi
BACKGROUND: Kososan, a Kampo (traditional Japanese herbal) medicine, has been used for the therapy of depressive mood in humans. However, evidence for the antidepressant efficacy of kososan and potential mechanisms are lacking. Recently, it has been recognized that stress triggers neuroinflammation and suppresses adult neurogenesis, leading to depression and anxiety. Here, we examined whether kososan extract affected social behavior in mice exposed to chronic social defeat stress (CSDS), an animal model of prolonged psychosocial stress, and neuroinflammation induced by CSDS...
May 3, 2017: Journal of Neuroinflammation
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