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Inflammatory mechanisms depression

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https://www.readbyqxmd.com/read/29656032/bioenergetics-and-synaptic-plasticity-as-potential-targets-for-individualizing-treatment-for-depression
#1
REVIEW
J Blair Price, Carrie Bronars, Sophie Erhardt, Kathyrn R Cullen, Lilly Schwieler, Michael Berk, Ken Walder, Sean L McGee, Mark A Frye, Susannah J Tye
Disruptions of bioenergetic signaling and neurogenesis are hallmarks of depression physiology and are often the product of dysregulation of the inflammatory, stress-response, and metabolic systems. These systems are extensively interrelated at the physiological level, yet the bulk of the literature to date addresses pathophysiological mechanisms in isolation. A more integrated understanding of the etiology, progression, and treatment response profiles of depression is possible through wider consideration of relevant preclinical and clinical studies that examine the result of disruptions in these systems...
April 12, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29653194/chronic-agomelatine-treatment-prevents-comorbid-depression-in-the-post-status-epilepticus-model-of-acquired-epilepsy-through-suppression-of-inflammatory-signaling
#2
Jana Tchekalarova, Dimitrinka Atanasova, Lidia Kortenska, Milena Atanasova, Nikolai Lazarov
Inflammatory signal molecules are suggested to be involved in the mechanism underlying comorbid depression in epilepsy. In the present study, we tested the hypothesis that the novel antidepressant agomelatine, a potent melatonin MT1 and MT2 receptor agonist and serotonin 5HT2C receptor antagonist, can prevent depressive symptoms developed during the chronic epileptic phase by suppressing an inflammatory response. Chronic treatment with agomelatine (40 mg/kg, i.p.) was initiated an hour after the kainate acid (KA)-induced status epilepticus (SE) and maintained for a period of 10 weeks in Wistar rats...
April 10, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29649568/honokiol-alleviates-the-degeneration-of-intervertebral-disc-via-suppressing-the-activation-of-txnip-nlrp3-inflammasome-signal-pathway
#3
Pan Tang, Jia-Ming Gu, Zi-Ang Xie, Yu Gu, Zhi-Wei Jie, Kang-Mao Huang, Ji-Ying Wang, Shun-Wu Fan, Xue-Sheng Jiang, Zhi-Jun Hu
Intervertebral disc degeneration (IVDD) is a multifactorial disease and responsible for many spine related disorders, causes disability in the workforce and heavy social costs all over the world. Honokiol, a low molecular weight natural product, could penetrate into and distribute in IVDs to achieve therapeutic effect in a rat tail model. Therefore, the present study was undertaken to examine the antiinflammatory, antioxidation and chondroprotective effect of honokiol using nucleus pulposus cells and investigate its mechanisms to provide a new basis for future clinical treatment of IVDD...
April 9, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29644391/analysis-on-sarcoglycans-expression-as-markers-of-septic-cardiomyopathy-in-sepsis-related-death
#4
Elvira Ventura Spagnolo, Cristina Mondello, Debora Di Mauro, Giovanna Vermiglio, Alessio Asmundo, Elena Filippini, Angela Alibrandi, Giuseppina Rizzo
The post-mortem assessment of sepsis-related death can be carry out by many methods recently suggested as microbiological and biochemical investigations. In these cases, the cause of death is a multiple organ dysfunction due to a dysregulated inflammatory response occurring after the failure of infection control process. It was highlighted also that the heart can be a target organ in sepsis which determines the so-called septic cardiomyopathy characterized by myocardial depression. Several mechanisms to explain the pathophysiology of septic cardiomyopathy were suggested, but very few studies about the structural alterations of cardiac cells responsible for myocardial depression were carried out...
April 11, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29628283/weathering-the-storm-a-review-of-pre-pregnancy-stress-and-risk-of-spontaneous-abortion
#5
REVIEW
Tyralynn Frazier, Carol J Rowland Hogue, Elizabeth A Bonney, Kathryn M Yount, Brad D Pearce
The Weathering Effect is a theory that links stress exposure, over the life-course, with racial disparities in reproductive outcomes, through the effects of social adversity on a woman's body. The concept of maternal "weathering" captures cumulative somatic and psychological adversities that can exacerbate the effects of aging. Much of the evidence for weathering comes from observational studies linking self-report measures with reproductive outcomes. The purpose of this review is to explore biological mechanisms that underlie these observations...
March 1, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29627531/crp-genetic-variants-are-associated-with-mortality-and-depressive-symptoms-in-chronic-heart-failure-patients
#6
S Kittel-Schneider, M Kaspar, D Berliner, H Weber, J Deckert, G Ertl, S Störk, C Angermann, A Reif
OBJECTIVE: Heart failure (HF) is a complex medical condition with a multitude of genetic and other factors being involved in the pathogenesis. Emerging evidence points to an involvement of inflammatory mechanisms at least in subgroups of patients. The same is true for depression and depressive symptoms, which have a high prevalence in HF patients and are risk factors for the development and outcomes of cardiovascular disease. METHODS: In 936 patients of the Interdisciplinary Network Heart Failure (INH) program, CRP and IL-6 protein blood levels were measured and genetic variants (single nucleotide polymorphisms) of the CRP and IL6 gene analyzed regarding their influence on mortality...
April 5, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29626654/geniposide-improves-repeated-restraint-stress-induced-depression-like-behavior-in-mice-by-ameliorating-neuronal-apoptosis-via-regulating-glp-1r-akt-signaling-pathway
#7
Yinghua Zhao, Hongyan Li, Fang Fang, Tingting Qin, Wei Xiao, Zhenzhong Wang, Shiping Ma
Geniposide (GP), a bioactive iridoid glycoside isolated from Gardenia jasminoides Ellis, as well as an agonist of Glucagon-like peptide-1 receptor (GLP-1R), has been reported to exhibit antidepressant-like effects in several rodent models. However, the underlying mechanisms remain obscure. In this study, we mainly investigated the antidepressant-like effects of GP and explored the possible mechanisms associated with GLP-1R signaling by using the repeated restraint stress (RRS)-induced depression model of mice...
April 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29626340/neuroimmune-biomarkers-in-mental-illness
#8
James W Herron, Louis Nerurkar, Jonathan Cavanagh
Exploration of neuroimmune mechanisms is vital to the understanding of the pathogenesis and pathophysiology of mental disorders. Inflammatory and immune mechanisms are increasingly understood to underpin a number of neuropsychiatric disorders, with an ever-expanding evidence base drawn from basic science to large-scale epidemiological data. Unravelling of these mechanisms should lead to biomarker discovery and potential new avenues for therapeutics that modulate immunological mechanisms. Identification of neuroimmune biomarkers is vital to improving diagnosis, stratification and treatment of mental disorders...
April 7, 2018: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/29623033/aggression-social-stress-and-the-immune-system-in-humans-and-animal-models
#9
REVIEW
Aki Takahashi, Meghan E Flanigan, Bruce S McEwen, Scott J Russo
Social stress can lead to the development of psychological problems ranging from exaggerated anxiety and depression to antisocial and violence-related behaviors. Increasing evidence suggests that the immune system is involved in responses to social stress in adulthood. For example, human studies show that individuals with high aggression traits display heightened inflammatory cytokine levels and dysregulated immune responses such as slower wound healing. Similar findings have been observed in patients with depression, and comorbidity of depression and aggression was correlated with stronger immune dysregulation...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29618972/an-inflammation-centric-view-of-neurological-disease-beyond-the-neuron
#10
REVIEW
Stephen D Skaper, Laura Facci, Morena Zusso, Pietro Giusti
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often results from an inappropriate immune response. Inflammation in the nervous system ("neuroinflammation"), especially when prolonged, can be particularly injurious. While inflammation per se may not cause disease, it contributes importantly to disease pathogenesis across both the peripheral (neuropathic pain, fibromyalgia) and central [e...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29615850/interplay-between-the-gut-brain-axis-obesity-and-cognitive-function
#11
REVIEW
Ana Agustí, Maria P García-Pardo, Inmaculada López-Almela, Isabel Campillo, Michael Maes, Marina Romaní-Pérez, Yolanda Sanz
Obesity continues to be one of the major public health problems due to its high prevalence and co-morbidities. Common co-morbidities not only include cardiometabolic disorders but also mood and cognitive disorders. Obese subjects often show deficits in memory, learning and executive functions compared to normal weight subjects. Epidemiological studies also indicate that obesity is associated with a higher risk of developing depression and anxiety, and vice versa . These associations between pathologies that presumably have different etiologies suggest shared pathological mechanisms...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29614774/the-brain-intestinal-mucosa-appendix-microbiome-brain-loop
#12
Luis Vitetta, Gemma Vitetta, Sean Hall
The brain and the gut are connected from early fetal life. The mother's exposure to microbial molecules is thought to exert in utero developmental effects on the fetus. These effects could importantly underpin the groundwork for subsequent pathophysiological mechanisms for achieving immunological tolerance and metabolic equilibrium post birth, events that continue through to 3-4 years of age. Furthermore, it is understood that the microbiome promotes cues that instruct the neonate's mucosal tissues and skin in the language of molecular and cellular biology...
April 1, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29601943/lung-injury-depresses-glutamatergic-synaptic-transmission-in-the-nucleus-tractus-solitarii-via-discrete-age-dependent-mechanisms-in-neonatal-rats
#13
David G Litvin, Thomas E Dick, Corey B Smith, Frank J Jacono
Transition periods (TPs) are brief stages in CNS development where neural circuits can exhibit heightened vulnerability to pathologic conditions such as injury or infection. This susceptibility is due in part to specialized mechanisms of synaptic plasticity, which may become activated by inflammatory mediators released under pathologic conditions. Thus, we hypothesized that the immune response to lung injury (LI) mediated synaptic changes through plasticity-like mechanisms that depended on whether LI occurred just before or after a TP...
March 27, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29599709/caffeine-and-modafinil-ameliorate-the-neuroinflammation-and-anxious-behavior-in-rats-during-sleep-deprivation-by-inhibiting-the-microglia-activation
#14
Meetu Wadhwa, Garima Chauhan, Koustav Roy, Surajit Sahu, Satyanarayan Deep, Vishal Jain, Krishna Kishore, Koushik Ray, Lalan Thakur, Usha Panjwani
Background : Sleep deprivation (SD) plagues modern society due to the professional demands. It prevails in patients with mood and neuroinflammatory disorders. Although growing evidence suggests the improvement in the cognitive performance by psychostimulants during sleep-deprived conditions, the impending involved mechanism is rarely studied. Thus, we hypothesized that mood and inflammatory changes might be due to the glial cells activation induced modulation of the inflammatory cytokines during SD, which could be improved by administering psychostimulants...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29593576/vagus-nerve-as-modulator-of-the-brain-gut-axis-in-psychiatric-and-inflammatory-disorders
#15
REVIEW
Sigrid Breit, Aleksandra Kupferberg, Gerhard Rogler, Gregor Hasler
The vagus nerve represents the main component of the parasympathetic nervous system, which oversees a vast array of crucial bodily functions, including control of mood, immune response, digestion, and heart rate. It establishes one of the connections between the brain and the gastrointestinal tract and sends information about the state of the inner organs to the brain via afferent fibers. In this review article, we discuss various functions of the vagus nerve which make it an attractive target in treating psychiatric and gastrointestinal disorders...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29577194/cytokine-production-by-splenic-cells-in-c57bl-6j-mice-with-depression-like-behavior-depends-on-the-duration-of-social-stress
#16
G V Idova, E V Markova, M M Gevorgyan, E L Al'perina, S Ya Zhanaeva
We studied the influence of depression-like behavior developed in C57BL/6J mice under conditions of social stress of different duration on cytokine production by splenic cells. Imbalance of the pro- and anti-inflammatory cytokines was detected at the early stage of depression-like behavior (10-day experience of defeats): increased production of proinflammatory IL-2 and IL-6 cytokines along with a decrease in anti-inflammatory IL-10 level; the levels of IL-1β, TNFα, IFNγ, and IL-4 remained unaffected. At later terms (20 days of confrontations), we revealed more pronounced changes in spontaneous production of proinflammatory cytokines that were not detected after shorter social stress...
March 26, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29575635/biomarkers-as-common-data-elements-for-symptom-and-self-management-science
#17
Gayle G Page, Elizabeth J Corwin, Susan G Dorsey, Nancy S Redeker, Donna Jo McCloskey, Joan K Austin, Barbara J Guthrie, Shirley M Moore, Debra Barton, Miyong T Kim, Sharron L Docherty, Drenna Waldrop-Valverde, Donald E Bailey, Rachel F Schiffman, Angela Starkweather, Teresa M Ward, Suzanne Bakken, Kathleen T Hickey, Cynthia L Renn, Patricia Grady
PURPOSE: Biomarkers as common data elements (CDEs) are important for the characterization of biobehavioral symptoms given that once a biologic moderator or mediator is identified, biologically based strategies can be investigated for treatment efforts. Just as a symptom inventory reflects a symptom experience, a biomarker is an indicator of the symptom, though not the symptom per se. The purposes of this position paper are to (a) identify a "minimum set" of biomarkers for consideration as CDEs in symptom and self-management science, specifically biochemical biomarkers; (b) evaluate the benefits and limitations of such a limited array of biomarkers with implications for symptom science; (c) propose a strategy for the collection of the endorsed minimum set of biologic samples to be employed as CDEs for symptom science; and (d) conceptualize this minimum set of biomarkers consistent with National Institute of Nursing Research (NINR) symptoms of fatigue, depression, cognition, pain, and sleep disturbance...
March 25, 2018: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/29575259/crocin-improves-renal-function-by-declining-nox-4-il-18-and-p53-expression-levels-in-an-experimental-model-of-diabetic-nephropathy
#18
Habib Yaribeygi, Mohammad T Mohammadi, Ramin Rezaee, Amirhossein Sahebkar
Oxidative damage, inflammation and apoptosis play significant roles in diabetic nephropathy. Previous studies demonstrated anti-inflammatory and anti-oxidative effects of crocin, but there is no evidence about its effects on IL-18, NOX-4, and p53 expression in diabetic kidneys. The aim of this study was to evaluate possible effects of crocin on improving main mechanisms underlying diabetic nephropathy. Male Wistar rats were randomly divided into four separate groups as normal (C), normal treated (CC), diabetic (D), and diabetic treated (DC) (n = 6)...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29564590/proteomic-analysis-of-the-antidepressant-effects-of-shen-zhi-ling-in-depressed-patients-identification-of-proteins-associated-with-platelet-activation-and-lipid-metabolism
#19
Chao Chen, Yuan Hu, Xian-Zhe Dong, Xiao-Jiang Zhou, Li-Hua Mu, Ping Liu
Shen-Zhi-Ling (SZL) is a Chinese medicine formulated from a Kai-Xin-San decoction that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. However, the underlying mechanisms remain unclear. We investigated biological changes in depression patients (DPs) exhibiting antidepressant responses to SZL treatment using proteomic techniques. We performed label-free quantitative proteomic analysis and liquid chromatography-tandem mass spectrometry to discover and examine altered proteins involved in depression and antidepressant treatment...
March 21, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29561292/behavioral-effects-of-toll-like-receptor-4-antagonist-eritoran-in-an-experimental-model-of-depression-role-of-prefrontal-and-hippocampal-neurogenesis-and-%C3%AE-aminobutyric-acid-glutamate-balance
#20
Sawsan Aboul-Fotouh, Mohamed Habib, Tarek Asaad, Samar K Kassim, Mohamed H Ghanem
Depression is the disease of the modern era. The lack of response to the available antidepressants, which were developed on the basis of the monoaminergic deficit hypothesis of depression, has encouraged scientists to think about new mechanisms explaining the pathogenesis of depression. In this context, the inflammatory theory has emerged to clarify many aspects of depression that the previous theories have failed to explain. Toll-like receptor-4 (TLR-4) has a regulatory role in the brain's immune response to stress, and its activation is suggested to play a pivotal role in the pathophysiology of depression...
March 20, 2018: Behavioural Pharmacology
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