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JOURNAL ARTICLE
Laura D P R van Maldegem, Johanna A van der Zande, Lucy A van Werkhoven, Patricia C Ewing-Graham, Bernadette A M Heemskerk-Gerritsen, Helena C van Doorn
INTRODUCTION: Recurrent postmenopausal bleeding (PMB) occurs in 6%-25% of postmenopausal women who have experienced a previous episode of PMB. The question of whether recurrent PMB leads to a higher risk of endometrial cancer (EC) in comparison to a single episode of PMB is, however, controversial. Furthermore, little is known about predictive factors for recurrent PMB. MATERIAL AND METHODS: A multicenter prospective cohort study was conducted over a 5-year period in four hospitals in the Netherlands...
May 2, 2024: Acta Obstetricia et Gynecologica Scandinavica
#22
Zhensheng Liu, Jian Bian, Yong Yang, Decheng Wei, Shiqin Qi
Ewing's Sarcoma (ES) is an rare, small round-cell sarcoma that predominantly occurs in children and young adults, with both skeletal and extraskeletal manifestations. However, pancreatic ES, due to its rarity, is infrequently featured in scholarly literature, with only a scant 43 reported instances. Our study describes a case of pancreatic ES in an 8-year-old boy who was found to have an abdominal mass. Following an exhaustive examination, the boy was diagnosed with a neoplasm in the pancreatic head and underwent a complex surgical procedure encompassing pancreatoduodenectomy and partial transverse colectomy...
2024: Frontiers in Oncology
#23
REVIEW
Ken-Ichi Yoshida, Akihiko Yoshida
Primary sarcoma of the lung and mediastinum is rare. The diagnosis requires careful exclusion of sarcomatoid carcinoma, sarcomatoid mesothelioma, and metastases from extra-thoracic sites. This review summarizes the key morphologic, immunohistochemical, and molecular characteristics of sarcomas that are encountered in the lung and mediastinum. The tumor types discussed are synovial sarcoma, well-differentiated/dedifferentiated liposarcoma, myxoid pleomorphic liposarcoma, intimal sarcoma of the pulmonary artery, inflammatory myofibroblastic tumor, epithelioid hemangioendothelioma, primary pulmonary myxoid sarcoma, malignant peripheral nerve sheath tumor, Ewing sarcoma, and CIC-rearranged sarcoma...
June 2024: Surgical Pathology Clinics
#24
JOURNAL ARTICLE
Mayra Trujillo, Anne Conan, Ana Cláudia Calchi, Katja Mertens-Scholz, Anna Becker, Christa Gallagher, Alex Mau, Silvia Marchi, Marcus Machado, Marcos Rogério André, Aspinas Chapwanya, Ananda Müller
This study aimed to evaluate the bacterial burden and perform molecular characterization of Coxiella burnetii during shedding in pregnant (vaginal, mucus and feces) and postpartum (vaginal mucus, feces and milk) ewes from Saint Kitts. Positive IS1111 DNA (n=250) for C. burnetii samples from pregnant (n=87) and postpartum (n=74) Barbados Blackbelly ewes in a previous investigation were used for this study. Vaginal mucus (n=118), feces (n=100), and milk (n=32) positive IS1111 C. burnetii-DNA were analysed by real time qPCR (icd gene)...
April 26, 2024: Comparative Immunology, Microbiology and Infectious Diseases
#25
JOURNAL ARTICLE
Marian Schini, Tatiane Vilaca, Li-Yung Lui, Susan K Ewing, Austin Thompson, Eric Vittinghoff, Douglas C Bauer, Mary L Bouxsein, Dennis M Black, Richard Eastell
Some osteoporosis drug trials have suggested that treatment is more effective in those with low bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). This study used data from a large set of randomised controlled trials (RCTs) to determine whether the anti-fracture efficacy of treatments differs according to baseline BMD. We used individual patient data from 25 RCTs (103 086 subjects) of osteoporosis medications collected as part of the FNIH-ASBMR SABRE project. Participants were stratified into femoral neck (FN) BMD T-score subgroups (≤ -2...
May 1, 2024: Journal of Bone and Mineral Research
#26
REVIEW
Lorenzo Andreani, Edoardo Ipponi, Alfio Damiano Ruinato, Tommaso Lupi, Federico Di Sacco, Duccio Volterrani, Luca Coccoli, Rodolfo Capanna
Osteosarcoma (OS) and Ewing sarcoma (ES) represent the pediatric population's most common malignant bone tumors. 18-Fluorodeoxyglucose positron emission tomography has been shown to be effective in both the diagnostic and staging phases of cancer treatment. In recent years, some studies have also explored the possibility that FDG-PET could have a prognostic role.
April 30, 2024: Folia Medica
#27
REVIEW
Yu Liu, Tony El Jabbour, Jonathan Somma, Yukihiro Nakanishi, Saverio Ligato, Hwajeong Lee, Zhi-Yan Fu
Blastomas, characterized by a mixture of mesenchymal, epithelial, and undifferentiated blastematous components, are rare malignant neoplasms originating from precursor blast cells. This review focuses on digestive system blastomas in adult patients, including gastroblastoma, hepatoblastoma, and pancreatoblastoma. Gastroblastoma is a biphasic, epitheliomesenchymal tumor, with only sixteen cases reported to date. In addition to the characteristic histology, metastasis-associated lung adenocarcinoma transcript 1 - glioma-associated oncogene homolog 1 gene fusion is typical, although recently novel ewing sarcoma breakpoint region 1 - c-terminal binding protein 1 and patched 1 - glioma-associated oncogene homolog 2 fusions have been described...
April 27, 2024: World Journal of Gastrointestinal Surgery
#28
REVIEW
Jiawei Yin, Peng Ren
Bone sarcomas encompass a group of spontaneous mesenchymal malignancies, among which osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma are the most common subtypes. Chondrosarcoma, a relatively prevalent malignant bone tumor that originates from chondrocytes, is characterized by endogenous cartilage ossification within the tumor tissue. Despite the use of aggressive treatment approaches involving extensive surgical resection, chemotherapy, and radiotherapy for patients with osteosarcoma, chondrosarcoma, and chordoma, limited improvements in patient outcomes have been observed...
April 1, 2024: Journal of Cancer Research and Therapeutics
#29
JOURNAL ARTICLE
Andra E Nica, Emilia Rusu, Carmen G Dobjanschi, Florin Rusu, Oana A Parliteanu, Claudia Sivu, Gabriela Radulian
INTRODUCTION: Cardiac autonomic neuropathy (CAN) is a disorder affecting the autonomic nerves that regulate the cardiovascular system, leading to irregular heart rate and blood pressure control. It is commonly associated with diabetes mellitus but can also result from other conditions such as autoimmune disorders, chronic kidney disease, alcohol abuse, and certain medications. Screening for CAN is essential, particularly in individuals with poor glycemic control, cardiovascular risk factors, or complications...
March 2024: Curēus
#30
JOURNAL ARTICLE
Bassam Ali Abed Wahab, Mohammed H M Merah, Ahmed Dhahir Latif, Hasanain A J Gharban
BACKGROUND: Over the past decades, Capparis spinosa has been considered a traditional therapy for relieving different illnesses. Mastitis causes a decrease in milk production and is usually treated with injectable and intra-mammary antibiotics. AIM: Investigating the therapeutic effects of C. spinosa root extract on subclinically mastitic ewes. METHODS: Totally, 164 lactating ewes were selected randomly from the flocks that existed in some areas belonging to Al-Najaf City (Najaf, Iraq) from September to December (2022)...
March 2024: Open Veterinary Journal
#31
JOURNAL ARTICLE
Shivang Shukla, Abhijeet Ashok Salunke, Maharshi Trivedi, Keval Patel, Shivam Pandya, Ritesh Suthar, Tarun Reddy, Kanika Kapoor, Poojitha Yala, Geetha Krishna, Nandlal Bharwani, Shashank Pandya
BACKGROUND: Ewing's sarcoma is highly aggressive bone tumor having predilection for younger age groups with t (11,22) translocation, recombines the FLI-1 and EWS genes on chromosome 22. This disease requires multi-disciplinary treatment withneo-adjuvant chemotherapy followed by surgery or radiotherapy and adjuvant chemotherapy. This study was aimed to assess the demographic distribution, clinical behaviour and oncological outcome of Ewings Sarcoma involving upper extremity. METHODS: From 2015 to 2022, 45 patients of upper extremity Ewing's sarcoma underwent treatment at a territory cancer centre...
March 2024: Journal of Orthopaedics
#32
Wajdi Chermiti, Mohamed Khiareddine, Amir Mhiri, Mourad Mtaoumi, Mahmoud Ben Maitigue, Karim Bouattour
INTRODUCTION: Ewing's sarcoma is the second most common primary malignant bone tumor in children and adolescents, after osteosarcoma. It is a rare tumor, with the axial skeleton being the preferred site of development, followed by the long bones. Diagnosis is evoked by imaging and confirmed by histology. Treatment is based on intensive chemotherapy with local surgical treatment in operable forms, and in some cases, radiotherapy. There are only a few sporadic cases in the literature describing distal fibular localization...
April 2024: Journal of Orthopaedic Case Reports
#33
Vikas Deep Goyal, Shubhanshu Gupta, Akhilesh Pahade, Gaurav Misra, Neeraj Prajapati
Ewing's sarcoma of the kidney is a rare tumor. Although renal carcinomas are known to involve the inferior cava, extension of the tumor up to the right atrium is not common. In the majority of cases when the tumor extends into the infrahepatic part of the inferior vena cava, it can be removed from the abdominal approach. Few patients require the use of cardiopulmonary bypass for removal of the tumor in the inferior vena cava and right atrium. The management of patients requiring resection of kidney tumors and right atrial mass is more complicated and requires a team approach consisting of oncosurgeons, cardiac surgeons, and cardiac anesthetists...
May 2024: Indian Journal of Thoracic and Cardiovascular Surgery
#34
Bryan M Greenfield, Madeleine A Wilson, Kyle J Schulte, Stephen Silverstein
While Ewing sarcoma is traditionally a malignant tumor of bone, it may uncommonly present extra-skeletally, leading to an array of puzzling presentations depending on the tissue involved. Here, we describe the case of a 66-year-old man who presented to the primary care office for evaluation of intermittent melena. He ultimately underwent capsule endoscopy and developed a secondary small bowel obstruction, unveiling his neoplasm. The tumor was then resected and managed with surveillance only, and the patient remains without evidence of disease after four years of follow-up...
March 2024: Curēus
#35
JOURNAL ARTICLE
Faris S Imran, Tahreer M Al-Thuwaini
The detection of polymorphisms in genes that control livestock reproduction could be highly beneficial for identifying and enhancing economic traits. One of these genes is pentraxin 3 ( PTX3 ), which affects the reproduction of sheep. Therefore, this study investigated whether the variability of the PTX3 gene was related to the litter size of Awassi and Hamdani ewes. A total of 200 ewes (130 Awassi and 70 Hamdani) were used for genomic DNA extraction. Polymerase chain reaction was used to amplify the sequence fragments of exons 1, 2, 3, and 4 from the PTX3 gene (Oar_v4...
2024: Bioinformatics and Biology Insights
#36
JOURNAL ARTICLE
Audra J Reiter, Lynn Huang, Brian T Craig, Andrew M Davidoff, Lindsay J Talbot, Jordan Coggins, Jasmine Smith, Jennifer H Aldrink, Katherine C Bergus, Taleen A MacArthur, Stephanie F Polites, Chloe Boehmer, Joseph Brungardt, Marcus M Malek, Hannah N Rinehardt, Zachary J Kastenberg, Cameron M Arkin, Antoine Gourmel, Nelson Piche, Marshall Wallace, Jiancong Liang, Harold N Lovvorn, Robin T Petroze, Gwendolyn Gillies, John P Marquart, Kerri Becktell, Hau D Le, Juan Favela, Barrie S Rich, Richard D Glick, Natashia M Seemann, Jacob Davidson, Claire A Wilson, Jonathan Roach, Erin G Brown, Kathleen E Doyle, Brian A Coakley, Pamela Emengo, Pamela Merola, Christa N Grant, Anuritha Tirumani, Elisabeth T Tracy, Mary E Moya-Mendez, Roshni Dasgupta, Timothy B Lautz
PURPOSE: Our objectives were to compare overall survival (OS) and pulmonary relapse between patients with metastatic Ewing sarcoma (EWS) at diagnosis who achieve rapid complete response (RCR) and those with residual pulmonary nodules after induction chemotherapy (non-RCR). PATIENTS AND METHODS: This retrospective cohort study included children under 20 years with metastatic EWS treated from 2007 to 2020 at 19 institutions in the Pediatric Surgical Oncology Research Collaborative...
April 28, 2024: Pediatric Blood & Cancer
#37
JOURNAL ARTICLE
L Li, M Zhang, T T Zhang, Y Ding
Objective: To investigate the clinical application of EWSR1 gene rearrangement by fluorescence in situ hybridization (FISH) in bone and soft tissue tumors and to analyze the cases with atypical signal pattern. Methods: The cases detected for EWSR1 gene rearrangement by FISH in Beijing Jishuitan Hospital, Capital Medical University from 2014 to 2021 were collected, and the value of detecting EWSR1 gene rearrangement for diagnosing bone and soft tissue tumors was analyzed. The cases with atypical positive signals were further analyzed by next generation sequencing (NGS)...
May 8, 2024: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
#38
JOURNAL ARTICLE
Aphrodite I Kalogianni, Ilias Bouzalas, Sofia Marka, Maria-Eleftheria Zografaki, Sofia Mavrikou, Athanasios I Gelasakis
The high genetic heterogeneity of small ruminant lentiviruses (SRLV) renders the genetic characterization of the circulating strains crucial for the epidemiological investigation and the designation of effective diagnostic tools. In Greece, research data regarding the genetic diversity of the circulating SRLV strains is scarce, hindering the implementation of efficient surveillance and control programs. The objective of the study was to genetically characterize SRLV strains isolated from intensive dairy sheep farms in Greece and evaluate the variability of the immunodominant regions of the capsid protein...
March 31, 2024: Viruses
#39
JOURNAL ARTICLE
Danielle Hildegard Bass, Pardis Ghamasaee, Gregory E Bigford, Mandeville Wakefield, Lunthita M Duthely, Daniel Samano
(1) Background: Climate change is increasing the already frequent diverse extreme weather events (EWE) across geographic locations, directly and indirectly impacting human health. However, current ongoing research fails to address the magnitude of these indirect impacts, including healthcare access. Vulnerable populations such as persons with spinal cord injury (pSCI) face added physiologic burden such as thermoregulation or mobility challenges like closure of public transportation. Our exploratory research assessed commute and transport to healthcare facilities as well as the knowledge, attitudes and behaviors (KAB) of pSCI regarding EWE and climate change when compared to pSCI caregivers (CG) and the general public (GP)...
March 22, 2024: International Journal of Environmental Research and Public Health
#40
JOURNAL ARTICLE
Maria Kruglova, Nikolai Nikitin, Ekaterina Evtushenko, Irina Matveeva, Aleksandr Mazurov, Igor Pavlenko, Vera Popova, Olesya Bogomolova, Stepan Vasilyev, Evgeniya Markova, Yuri Fedorov
Chlamydia abortus is the etiological agent of abortion and fetal loss in sheep, goats and bovine cattle in many countries. Even though commercially available vaccines can reduce the incidence in sheep, the development of new, safe, and effective vaccines remains high on the agenda. In this study, an evaluation was made of the efficacy of a vaccine candidate, an inactivated antigen based on the extract of outer membrane proteins of a C. abortus strain known as Chlamydia VNITIBP-21 , in combination with recombinant flagellin as an adjuvant...
March 24, 2024: Pathogens
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