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https://www.readbyqxmd.com/read/28793231/association-of-mitochondrial-dna-10398-a-g-polymorphism-with-attention-deficit-and-hyperactivity-disorder-in-korean-children
#1
In Wook Hwang, Jun Ho Hong, Bit Na Kwon, Hyung Jun Kim, Nu Ri Lee, Myung Ho Lim, Ho Jang Kwon, Han Jun Jin
Mitochondria are subcellular organelles that contribute to aerobic ATP generation by oxidative phosphorylation (OXPHOS). Previous studies reported that mitochondrial dysfunction and deficiency caused by mitochondrial DNA polymorphisms is associated with various diseases. Especially, mitochondrial DNA 10398 A/G polymorphism is known to affect the regulation of mitochondrial calcium levels related to energy production, and its association with psychiatric disorders such as schizophrenia and bipolar disorder has been reported...
August 6, 2017: Gene
https://www.readbyqxmd.com/read/28770037/adhd-related-symptoms-and-attention-profiles-in-the-unaffected-siblings-of-probands-with-autism-spectrum-disorder-focus-on-the-subtypes-of-autism-and-asperger-s-disorder
#2
Yi-Ling Chien, Miao-Chun Chou, Yen-Nan Chiu, Wen-Jiun Chou, Yu-Yu Wu, Wen-Che Tsai, Susan Shur-Fen Gau
BACKGROUND: The presence of attention-deficit/hyperactive disorder (ADHD) symptoms and impaired attention performance are commonly noted in individuals with autism spectrum disorder (ASD). However, little is known about attention performance in their unaffected siblings. This study aimed to investigate the ADHD-related traits and attention performance in unaffected siblings of probands with autism and Asperger syndrome (AS), as well as the clinical correlates of ADHD-related traits. METHODS: We assessed the intention, hyperactivity-impulsivity, and oppositional symptoms, and attention profiles of 199 probands with a diagnosis of ASD (122 autism, 77 AS), their unaffected siblings, and 196 typically developing controls (TD) by their parents' reports on the ADHD-related symptoms and the Connors' Continuous Performance Test (CCPT), respectively...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28763378/facial-emotion-recognition-deficits-in-children-with-and-without-attention-deficit-hyperactivity-disorder-a-behavioral-and-neurophysiological-approach
#3
Laura Rinke, Gian Candrian, Sarah Loher, Andrea Blunck, Andreas Mueller, Lutz Jäncke
The current study examined the facial emotion recognition ability with a simultaneous assessment of behavioral and neurophysiological data in children with and without attention deficit hyperactivity disorder (ADHD) aged 7-7 years using a facial emotion matching task and event-related potential measurements (event-related potential components N170 and N250 at T5 and T6) in an emotional continuous performance task. Group differences and interaction effects of children's performance (both behavioral and neurophysiological) were evaluated between children with ADHD and children without ADHD as well as between younger and older children...
July 31, 2017: Neuroreport
https://www.readbyqxmd.com/read/28761201/the-impact-of-methylphenidate-on-motor-performance-in-children-with-both-attention-deficit-hyperactivity-disorder-and-developmental-coordination-disorder-a-randomized-double-blind-crossover-clinical-trial
#4
Robabeh Soleimani, Maryam Kousha, Homa Zarrabi, Seyede Mahnaz Tavafzadeh-Haghi, Mir Mohammad Jalali
BACKGROUND: Children with attention deficit hyperactivity disorder/developmental coordination disorder (ADHD/DCD) suffer from problems associated with gross and fine motor skills. There is no effective pharmacological therapy for such patients. We aimed to assess the impact of methylphenidate (MPH) on motor performance of children with ADHD/DCD. METHODS: In this double-blind placebo-controlled, 17 children (12 boys) with ADHD/DCD with a mean age of 7 years 6 months were recruited in Shafa Hospital, Rasht, Iran...
July 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28760090/the-impact-of-emotional-lability-symptoms-during-childhood-in-adults-with-adhd
#5
Laura Gisbert, Vanesa Richarte, Montserrat Corrales, Pol Ibáñez, Rosa Bosch, Miquel Casas, Josep Antoni Ramos-Quiroga
OBJECTIVE: To determine whether emotional lability (EL) in adult ADHD patients can already be identified during their childhood and the extent to which this childhood symptomatology can predict EL in adulthood. METHOD: Seven hundred eighteen adults with ADHD were examined. EL in adulthood was assessed using the Conners' Adult ADHD Rating Scales (CAARS). According to Conners' definition of EL, seven items from the Wender Utah Rating Scale (WURS) were used to determine this symptomatology in childhood...
July 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28750278/neuropsychological-deficits-in-adults-age-60-and-above-with-attention-deficit-hyperactivity-disorder
#6
L B Thorell, Y Holst, H Chistiansen, J J S Kooij, D Bijlenga, D Sjöwall
OBJECTIVE: Neuropsychological deficits are of major importance in ADHD, yet no previous studies have assessed clinically referred samples of older adults. The authors compared older adults with ADHD (60-75years) with both younger adults with ADHD (18-45years) and older healthy controls with regard to various neuropsychological deficits. METHODS: Well-established tests were used to investigate working memory, inhibition, switching, planning, fluency, and speed of processing...
June 27, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28710695/serum-brain-derived-neurotrophic-factor-levels-in-treatment-na%C3%A3-ve-boys-with-attention-deficit-hyperactivity-disorder-treated-with-methylphenidate-an-8-week-observational-pretest-posttest-study
#7
Aynur Pekcanlar Akay, Halil Resmi, Sevay Alsen Güney, Handan Özek Erkuran, Gonca Özyurt, Enis Sargin, Ahmet Topuzoglu, Ali Evren Tufan
Brain-derived neurotrophic factor (BDNF) is an important neurotrophin in the brain that modulates dopaminergic neurons. In this study, we aimed to investigate the changes in serum BDNF levels of children with attention-deficit/hyperactivity disorder (ADHD) in response to OROS methylphenidate treatment. We also aimed to determine whether there were any pre-post-differences between ADHD subtypes and comorbid psychiatric disorders in serum BDNF levels. Fifty male children with ADHD and 50 male healthy controls within the age range of 6-12 years were recruited to the study...
July 14, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28705637/-do-children-with-attention-deficit-and-hyperactivity-disorder-adhd-have-a-diferent-gait-pattern-relationship-between-idiopathic-toe-walking-and-adhd
#8
Víctor Soto Insuga, Beatriz Moreno Vinués, Rebeca Losada Del Pozo, María Rodrigo Moreno, Marta Martínez González, Raquel Cutillas Ruiz, Carmen Mateos Carmen
INTRODUCTION: Idiopathic toe-walking (ITW) is described as a gait pattern with no contact between the heels and the ground in children older than 3years. The diagnosis is clinical, making it necessary to rule out other neurological and orthopaedic conditions. A relationship between ITW and vestibular dysfunction and/or proprioceptive sensibility has been proposed. Children with neurodevelopmental disorders (autism, language and cognitive disorders) often have ITW. OBJECTIVES: To determine the frequency of ITW in children with attention deficit disorder and hyperactivity (ADHD)...
July 10, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28701934/neuronal-intra-individual-variability-masks-response-selection-differences-between-adhd-subtypes-a-need-to-change-perspectives
#9
Annet Bluschke, Witold X Chmielewski, Moritz Mückschel, Veit Roessner, Christian Beste
Due to the high intra-individual variability in attention deficit/hyperactivity disorder (ADHD), there may be considerable bias in knowledge about altered neurophysiological processes underlying executive dysfunctions in patients with different ADHD subtypes. When aiming to establish dimensional cognitive-neurophysiological constructs representing symptoms of ADHD as suggested by the initiative for Research Domain Criteria, it is crucial to consider such processes independent of variability. We examined patients with the predominantly inattentive subtype (attention deficit disorder, ADD) and the combined subtype of ADHD (ADHD-C) in a flanker task measuring conflict control...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28699075/differential-brain-activations-in-adult-attention-deficit-hyperactivity-disorder-subtypes-a-counting-stroop-functional-mri-study
#10
Chi-Yung Shang, Chia Sheng, Li-Kuang Yang, Tai-Li Chou, Susan Shur-Fen Gau
Although previous functional neuroimaging studies have found abnormal brain activations in individuals with attention deficit hyperactivity disorder (ADHD), little was known about distinct brain dysfunctions across different ADHD subtypes. The objective of the present study was to investigate the abnormal brain activations associated with two ADHD subtypes, predominantly inattentive (ADHD-PI) and combined (ADHD-C) subtypes. Twenty-five adults with ADHD-PI, 25 with ADHD-C, and 30 healthy controls (HC) participated in this study...
July 11, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28670953/the-probable-role-of-adrenomedullin-and-nitric-oxide-in-childhood-attention-deficit-hyperactivity-disorder
#11
Börte Gürbüz Özgür, Hatice Aksu, Mustafa Yılmaz, Sevcan Karakoç Demirkaya
BACKGROUND: The role of adrenomedullin hormone, which has been shown to be associated with many psychiatric disorders, in the etiology of ADHD and its relation to disease is not yet known. AIM: In this study, it was aimed to compare plasma adrenomedullin and nitric oxide (NO) levels of newly diagnosed, treatment-naive patients with ADHD with healthy children. METHODS: A total of 45 children with ADHD and 45 healthy children were included. The Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS), a semi-structured interview, was applied to all cases by child and adolescent psychiatrist...
July 2, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28651666/genetic-and-phenotypic-overlap-of-specific-obsessive-compulsive-and-attention-deficit-hyperactive-subtypes-with-tourette-syndrome
#12
M E Hirschtritt, S M Darrow, C Illmann, L Osiecki, M Grados, P Sandor, Y Dion, R A King, D Pauls, C L Budman, D C Cath, E Greenberg, G J Lyon, D Yu, L M McGrath, W M McMahon, P C Lee, K L Delucchi, J M Scharf, C A Mathews
BACKGROUND: The unique phenotypic and genetic aspects of obsessive-compulsive (OCD) and attention-deficit/hyperactivity disorder (ADHD) among individuals with Tourette syndrome (TS) are not well characterized. Here, we examine symptom patterns and heritability of OCD and ADHD in TS families. METHOD: OCD and ADHD symptom patterns were examined in TS patients and their family members (N = 3494) using exploratory factor analyses (EFA) for OCD and ADHD symptoms separately, followed by latent class analyses (LCA) of the resulting OCD and ADHD factor sum scores jointly; heritability and clinical relevance of the resulting factors and classes were assessed...
June 27, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28622159/weeding-out-the-justification-for-marijuana-treatment-in-patients-with-developmental-and-behavioral-conditions
#13
Theodora Nelson, Yi Hui Liu, Kara S Bagot, Martin T Stein
Alex is a 13-year-old adolescent with high-functioning autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD)-combined type, anxiety, and depression. He has been resistant to engaging in therapy and treatment with various medications has been unsuccessful. Alex's parents are concerned about his anxiety, isolation, oppositional behaviors, academic underachievement, truancy, and substance use. A recent altercation with his stepfather led to a police intervention and a brief removal of Alex from the home...
July 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28614965/the-co-occurrence-of-autism-spectrum-disorder-in-children-with-adhd
#14
Benjamin Zablotsky, Matthew D Bramlett, Stephen J Blumberg
OBJECTIVE: Children with ADHD frequently present with autism spectrum disorder (ASD) symptomatology, yet there is a notable gap in the treatment needs of this subpopulation, including whether the presence of ASD may be associated with more severe ADHD symptoms. METHOD: Data from the 2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome ( n = 2,464) were used to compare children diagnosed with ADHD and ASD with children with ADHD, but not ASD...
June 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28593598/brief-report-macrocephaly-phenotype-and-psychiatric-comorbidity-in-a-clinical-sample-of-mexican-children-and-adolescents-with-autism-spectrum-disorders
#15
Lilia Albores-Gallo, Laura Fritsche-García, Arturo Pabel Miranda-Aguirre, Montserrat Avila-Acosta
Autism spectrum disorders (ASD) may present with macrocephaly. Few studies have analyzed the association with psychiatric comorbidity. Participants were 94 children with any ASD with an age range from 2 to 16 years (Mdn 6 years), 82% were boys. It was found that 20% of the sample had macrocephaly and 1% microcephaly. There was no association between the presence of macrocephaly and subtype of ASD. The most associated comorbidity was attention-deficit/hyperactivity disorder (ADHD) 54.2%, followed by specific phobia 34%, dysthimia 29...
June 7, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28587507/adhd-is-comorbid-to-migraine-in-childhood-a-population-based-study
#16
Marco Antônio Arruda, Renato Arruda, Vincenzo Guidetti, Marcelo Eduardo Bigal
OBJECTIVE: Recurrent headaches and ADHD are prevalent in the pediatric population. Herein, we assess if ADHD is comorbid to headaches overall, to headache subtypes (e.g., migraine), and to headache frequency. METHOD: Informed consent and analyzable data were obtained for 5,671 children aged 5 to 12 years (65.9% of the target sample). Parents and teachers were interviewed using validated questionnaires based on the Diagnostic and Statistical Manual of Mental Disorders (5th ed...
June 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28580295/regional-brain-network-organization-distinguishes-the-combined-and-inattentive-subtypes-of-attention-deficit-hyperactivity-disorder
#17
Jacqueline F Saad, Kristi R Griffiths, Michael R Kohn, Simon Clarke, Leanne M Williams, Mayuresh S Korgaonkar
Attention Deficit Hyperactivity Disorder (ADHD) is characterized clinically by hyperactive/impulsive and/or inattentive symptoms which determine diagnostic subtypes as Predominantly Hyperactive-Impulsive (ADHD-HI), Predominantly Inattentive (ADHD-I), and Combined (ADHD-C). Neuroanatomically though we do not yet know if these clinical subtypes reflect distinct aberrations in underlying brain organization. We imaged 34 ADHD participants defined using DSM-IV criteria as ADHD-I (n = 16) or as ADHD-C (n = 18) and 28 matched typically developing controls, aged 8-17 years, using high-resolution T1 MRI...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28562425/rotational-and-collic-vestibular-evoked-myogenic-potential-testing-in-normal-developing-children-and-children-with-combined-attention-deficit-hyperactivity-disorder
#18
Younes Lotfi, Nima Rezazadeh, Abdollah Moossavi, Hojjat Allah Haghgoo, Reza Rostami, Enayatollah Bakhshi, Faride Badfar, Sedigheh Farokhi Moghadam, Vahid Sadeghi-Firoozabadi, Yousef Khodabandelou
OBJECTIVES: Vestibular dysfunction in childhood can have a major effect on a child's developmental process. Balance function has been reported to be poorer in children with attention deficit and hyperactivity disorder (ADHD) than in their typically developing peers. Due to contradictory available evidence and the paucity of research on vestibular function specifically in children with combined ADHD (cADHD), we designed this aged-matched study to assess vestibular function in children with cADHD...
May 26, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28547881/prevalence-and-clinical-correlates-of-insomnia-in-adults-with-attention-deficit-hyperactivity-disorder
#19
E J Brevik, A J Lundervold, A Halmøy, M-B Posserud, J T Instanes, B Bjorvatn, J Haavik
OBJECTIVE: To investigate the prevalence of insomnia in adults with Attention-deficit hyperactivity disorder (ADHD) and its association with clinical subtypes, current ADHD symptoms, and stimulant treatment. METHOD: We obtained diagnostic information, symptom rating scales and treatment history from clinically ascertained adult ADHD patients diagnosed according to DSM-IV criteria (n = 268, mean age 38.1 years) and randomly selected population controls (n = 202, mean age 36...
May 26, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28538047/auditory-processing-disorder-what-does-it-mean-and-what-can-be-done
#20
Krista Bartlett, Elissa Kelley, Julie Purdy, Martin T Stein
Julian, an 11-year-old boy in the sixth grade with a compliant disposition and a positive attitude, has had a significant decline in his academic performance over the last 2 years. He spends much of his time in the nurse's office with headaches and fatigue. He reports that he cannot concentrate or follow along in class. Vision and hearing screenings were normal.Julian's teachers report that although he has no behavior problem, he is inattentive and does not put forth the effort she feels he is capable of giving...
June 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
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