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https://www.readbyqxmd.com/read/29038401/-surgical-resection-of-t4-category-lung-cancer
#1
Tetsuhiko Go, Kazuhito Nii, Hiroyasu Yokomise
Surgery still remains the main stream in the multimodality treatment for locally advanced lung cancer. On the other hand, more than 50% of non-small cell lung cancer are excluded for surgical indications, especially T4 category of lung cancer. In this study, we showed 5 year overall survival rate of both 50 clinical T4 cases and 30 pathological T4 cases are 35.6% and 41.9% respectively. Those could be compared with the non-surgical treatment results in the literature. Through this study and analysis of other reports, we might consider surgical indications for T4 category lung cancer are as follows;invasion to mediastinum, spine, trachea, carina and additional nodules in ipsilateral different lobes with N0-1 status(esophagus is not included in this study)...
October 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29038399/-surgical-resection-for-locally-advanced-lung-cancer
#2
Makoto Endoh, Satoshi Shiono, Katsuyuki Suzuki, Kei Yarimizu, Kazuki Hayasaka, Naoki Yanagawa
Lung cancer invading neighboring anatomical structures is categorized as T3 or T4 and is regarded as locally advanced lung cancer. The 8th Edition Lung Cancer Stage Classification reclassified tumors 5~7 cm in size as T3 and tumors >7 cm or invading the diaphragm as T4. The purpose of this study was to evaluate the treatment results for resectable cT3-4N0-1M0 non-small cell lung cancer. From 1985 to 2016, 138 patients were surgically treated in our hospital, and their median follow-up was 78 months. Overall, the 5-year survival was 50%...
October 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28922454/surgery-for-t4-lung-cancer-invading-the-thoracic-aorta-do-we-push-the-limits
#3
Giuseppe Marulli, Erino A Rendina, Walter Klepetko, Reinhold Perkmann, Davide Zampieri, Giulio Maurizi, Thomas Klikovits, Francesco Zaraca, Federico Venuta, Egle Perissinotto, Federico Rea
BACKGROUND: Few investigators have described en bloc resection of non-small cell lung cancer (NSCLC) invading the aorta. AIM OF STUDY: Analysis of outcome and prognostic factors for en bloc resections of NSCLC invading the aorta. METHODS: Thirty-five patients (27 males, 8 females; mean age 63 ± 8.6 years) were operated between 1994 and 2015 in four European Centers. HISTOLOGY: 12 (34.3%) squamous cell carcinoma, and 6 (17...
September 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28890815/the-role-of-neoadjuvant-radiotherapy-for-locally-advanced-rectal-cancer-with-resectable-synchronous-metastasis
#4
Croix C Fossum, Jasim Y Alabbad, Lindsay B Romak, Christopher L Hallemeier, Michael G Haddock, Marianne Huebner, Eric J Dozois, David W Larson
BACKGROUND: Although neoadjuvant radiotherapy is typically administered for locally-advanced rectal cancer to reduce local recurrence (LR), its role for patients who present with synchronous resectable liver and/or lung metastasis is not well defined. The aim of this study was to evaluate the role of neoadjuvant radiotherapy for patients with stage IV rectal cancer undergoing curative-intent surgery. METHODS: This study is a retrospective review of a prospectively maintained surgical registry of all consecutive adult patients who underwent curative-intent resection at Mayo Clinic in Rochester, MN, from January 1990 until December 2014 with a median follow-up time of 43 (IQR 16-67) months...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28882769/adjuvant-hepatic-artery-infusion-chemotherapy-after-hemihepatectomy-for-gastric-cancer-liver-metastases
#5
Yasuyuki Fukami, Yuji Kaneoka, Atsuyuki Maeda, Yuichi Takayama, Takamasa Takahashi, Masahito Uji, Takashi Kumada
BACKGROUND: The most frequent pattern of recurrence is remnant liver after hepatectomy for gastric cancer liver metastases (GLM). The evidence of adjuvant hepatic artery infusion chemotherapy (HAIC) after hepatectomy for GLM is lacking. The aim of this study was to evaluate the efficacy of adjuvant HAIC after hemihepatectomy for GLM. METHODS: Between 2001 and 2012, 14 patients who underwent hemihepatectomy for GLM were included in this study. Adjuvant HAIC to the remnant hemiliver was the FEM regimen (333 mg/m(2) 5-fluorouracil each week, 30 mg/m(2) epirubicin once every 4 weeks, and 2...
October 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28782727/adequacy-of-intraoperative-nodal-staging-during-surgical-resection-of-nsclc-influencing-factors-and-its-relationship-to-survival
#6
Tim Edwards, Haval Balata, Mohamed Elshafi, Philip Foden, Paul Bishop, Eustace Fontaine, Mark Jones, Piotr Krysiak, Kandadai Rammohan, Rajesh Shah, Philip Crosbie, Richard Booton, Matthew Evison
INTRODUCTION: Adequate intraoperative lymph node sampling is a fundamental part of lung cancer surgery, but adherence to standards is not well known. This study sought to measure the adequacy of intraoperative lymph node sampling at a regional Thoracic Surgery Centre and a tertiary lung cancer center in the United Kingdom. METHODS: This retrospective study analyzed the pathological reports from NSCLC resections over the 4-year period 2011-2014. Adequacy of sampling was assessed against International Association for the Study of Lung Cancer recommendations of at least three mediastinal lymph node stations: station 7 in all patients, station 5 or 6 in left upper lobe tumors, and station 9 in lower lobe tumors...
August 4, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28770339/evaluating-vertebral-artery-dominancy-before-t4-lung-cancer-surgery-requiring-subclavian-artery-reconstruction
#7
Yasuo Sekine, Yukio Saitoh, Mitsuru Yoshino, Eitetsu Koh, Atsushi Hata, Terunaga Inage, Hidemi Suzuki, Ichiro Yoshino
PURPOSES: To evaluate vertebral artery (VA) dominancy and the risk of brain infarction in T4 lung cancer patients with tumor invasion into the subclavian artery. METHODS: We reconstructed the subclavian artery in 10 patients with T4 non-small cell lung cancer. The histological stages were IIIA in eight patients and IIIB in two patients. We evaluated the VA dominancy by performing a four-vessel study preoperatively and investigated the relationship between the methods of VA treatment and postoperative brain complications, retrospectively...
August 2, 2017: Surgery Today
https://www.readbyqxmd.com/read/28577955/surgery-versus-chemotherapy-and-radiotherapy-for-early-and-locally-advanced-small-cell-lung-cancer-a-propensity-matched-analysis-of-survival
#8
E Wakeam, S A Acuna, N B Leighl, M E Giuliani, S R G Finlayson, T K Varghese, G E Darling
BACKGROUND: The role of surgery in small cell lung cancer (SCLC) is controversial. Survival outcomes for resection of stage I-IIIA SCLC compared to chemotherapy-based non-surgical treatment (NST) were examined using propensity matching. METHODS: 29,994 clinical stage I-IIIA SCLC patients, including 2,619 undergoing surgery, were identified in the National Cancer Database. Stage-specific propensity scores for receipt of surgery were created. Resected patients were matched 1:1 to those undergoing NST...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28349384/extended-surgery-for-t4-lung-cancer-a-30-years-experience
#9
REVIEW
P G Dartevelle, D Mitilian, E Fadel
T4 non-small cell lung carcinomas (NSCLC) were deemed unresectable. Advances in surgery have challenged this dogma. We describe technical aspects and result on superior vena cava (SVC), carinal, thoracic inlet tumor surgeries, and resection under cardiopulmonary bypass (CPB). SVC reconstruction requires hemodynamic control to reverse SVC clamping cerebral effects and excellent cephalic venous bed patency. Among 50 SVC resections, including 25 carinal pneumonectomies, post-operative mortality rate was 8%. In the N0-N1 group, 5- and 10-year survival rates were 46...
June 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28329213/postoperative-pulmonary-complications-and-rehabilitation-requirements-following-lobectomy-a-propensity-score-matched-study-of-patients-undergoing-video-assisted-thoracoscopic-surgery-versus-thoracotomy%C3%A2
#10
Paula Agostini, Sebastian T Lugg, Kerry Adams, Nelia Vartsaba, Maninder S Kalkat, Pala B Rajesh, Richard S Steyn, Babu Naidu, Alison Rushton, Ehab Bishay
OBJECTIVES: : Video-assisted thoracoscopic surgical (VATS) lobectomy is increasingly used for curative intent lung cancer surgery compared to open thoracotomy due to its minimally invasive approach and associated benefits. However, the effects of the VATS approach on postoperative pulmonary complications (PPC), rehabilitation and physiotherapy requirements are unclear; our study aimed to use propensity score matching to investigate this. METHODS: Between January 2012 and January 2016 all consecutive patients undergoing lobectomy via thoracotomy or VATS were prospectively observed...
June 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27811857/phase-ii-study-of-chemoselection-with-docetaxel-plus-cisplatin-and-5-fluorouracil-induction-chemotherapy-and-subsequent-conversion-surgery-for-locally-advanced-unresectable-oesophageal-cancer
#11
MULTICENTER STUDY
Tomoya Yokota, Ken Kato, Yasuo Hamamoto, Yasuhiro Tsubosa, Hirofumi Ogawa, Yoshinori Ito, Hiroki Hara, Takashi Ura, Takashi Kojima, Keisho Chin, Shuichi Hironaka, Takayuki Kii, Yasushi Kojima, Yasunori Akutsu, Hisayuki Matsushita, Kentaro Kawakami, Keita Mori, Yushi Nagai, Chika Asami, Yuko Kitagawa
BACKGROUND: The standard treatment for locally advanced unresectable squamous cell carcinoma (SCC) of the oesophagus is chemoradiation with cisplatin and 5-fluorouracil (CF-RT). This multicentre phase II trial assessed the safety and efficacy of chemoselection with docetaxel plus cisplatin and 5-fluorouracil (DCF) induction chemotherapy (ICT) and subsequent conversion surgery (CS) for initially unresectable locally advanced SCC of the oesophagus. METHODS: Patients with clinical T4 and/or unresectable supraclavicular lymph node metastasis were eligible...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27630311/feasibility-of-concomitant-chemoradiotherapy-in-daily-practice-for-patients-with-nsclc-stage-iii
#12
Femke S VAN DER Meer, Franz M N H Schramel, Marco VAN Vulpen, Sherif Y El Sharouni
BACKGROUND: In patients with non-small cell lung cancer (NSCLC), approximately 25% have locally advanced disease. For patients with irresectable (N2-3 or T4) or inoperable disease, treatment consists of chemoradiotherapy. Concomitant chemoradiotherapy improves survival compared to sequential chemoradiotherapy in these patients. PATIENTS AND METHODS: Treatment plans and completion of treatment was evaluated for all patients treated at the St. Antonius Hospital from 2008-2011 for NSCLC stage IIIA/B not eligible for surgery...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27373480/-survival-analysis-of-surgically-treated-renal-cell-carcinoma-an-analysis-of-10-year-data-from-single-center
#13
Y S Zhang, H Y Yu, F Dong, H Z Li
OBJECTIVE: To explore how clinical features of renal cell carcinoma (RCC) relate to cancer patients' prognosis and survival. METHODS: A total of 1 497 renal cell carcinoma patients received surgical treatments in Department of Urology, Peking Union Medical College were admitted between January 2002 and December 2012. Telephone interviews and complimentary medical records review were carried out to acquire follow-up data, including post-surgery adjuvant therapy, disease progression and survival...
July 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27345879/-the-clinical-characteristics-and-treatment-outcomes-of-386-patients-with-hypopharyngeal-cancer
#14
Y T Cao, L Zhou, H T Wu, X M Li, W T Huang, X L Chen, C Li, L Tao
OBJECTIVE: To investigate the clinical characteristics, surgical treatment outcomes and prognostic factors of hypopharyngeal carcinoma. METHODS: A retrospective review of the Eye & ENT Hospital of Fudan University patients' database between January 2003 and June 2013 was conducted and a total of 386 patients were enrolled in the study. Patients' clinical and oncological information was collected and survival rates were analyzed using Kaplan-Meier curves. Prognostic factors were evaluated with multivariate Cox model survival analysis...
June 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/26834478/video-assisted-thoracic-surgery-reduces-early-postoperative-stress-a-single-institutional-prospective-randomized-study
#15
Christos Asteriou, Achilleas Lazopoulos, Thomas Rallis, Apostolos S Gogakos, Dimitrios Paliouras, Kosmas Tsakiridis, Athanasios Zissimopoulos, Drosos Tsavlis, Konstantinos Porpodis, Wolfgang Hohenforst-Schmidt, Ioannis Kioumis, John Organtzis, Konstantinos Zarogoulidis, Paul Zarogoulidis, Nikolaos Barbetakis
BACKGROUND: Video-assisted thoracic surgery (VATS) has been shown to effectively reduce postoperative pain, enhance mobilization of the patients, shorten in-hospital length of stay, and minimize postoperative morbidity rates. The aim of this prospective study is to evaluate neuroendocrine and respiratory parameters as stress markers in cancer patients who underwent lung wedge resections, using both mini muscle-sparing thoracotomy and VATS approach. METHODS: The patients were randomly allocated into two groups: Group A (n=30) involved patients who were operated on using the VATS approach, while in group B (n=30), the mini muscle-sparing thoracotomy approach was used...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/26773741/population-based-patterns-of-surgical-care-for-stage-iiia-nsclc-in-the-netherlands-between-2010-and-2013
#16
Chris Dickhoff, Max Dahele, A Joop de Langen, Marinus A Paul, Egbert F Smit, Suresh Senan, Koen J Hartemink, Ronald A Damhuis
INTRODUCTION: Current guidelines include both induction therapy plus an operation and chemoradiotherapy (CRT) as options for clinical stage IIIA (cIIIA) non-small cell lung cancer (NSCLC) after multidisciplinary evaluation. We explored the use of operations for cIIIA NSCLC in the Netherlands. METHODS: Data about the primary treatment of patients with cIIIA NSCLC (according to the seventh edition of the Tumour, Node, and Metastasis Classification of Malignant Tumours) between 2010 and 2013 were extracted from the Netherlands Cancer Registry...
April 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/26342550/circulating-il-33-level-is-associated-with-the-progression-of-lung-cancer
#17
Myung Shin Kim, Eunsom Kim, Jeong-Seok Heo, Da-Jeong Bae, Jong-Uk Wook Lee, Tae-Hyeong Lee, Hyeon Ju Lee, Hun Soo Chang, Jong Sook Park, An Soo Jang, Eun Suk Koh, Hun Gyu Hwang, Guneil Lim, Soohyun Kim, Choon-Sik Park
OBJECTIVES: Interleukin (IL)-33 protects against infection and inflammation; however, few studies have explored the relevance of IL-33 in lung cancer patients. We evaluated relation of plasma IL-33 levels with development and progression of lung cancer. MATERIALS AND METHODS: A total of 160 patients with lung cancer and 160 controls with normal lungs were enrolled. Plasma IL-33 levels were measured using a specific sandwich ELISA; these levels were followed-up in 18 patients who underwent surgery and in 14 patients treated with chemotherapy...
November 2015: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/26134221/the-iaslc-lung-cancer-staging-project-proposals-for-the-revisions-of-the-t-descriptors-in-the-forthcoming-eighth-edition-of-the-tnm-classification-for-lung-cancer
#18
Ramón Rami-Porta, Vanessa Bolejack, John Crowley, David Ball, Jhingook Kim, Gustavo Lyons, Thomas Rice, Kenji Suzuki, Charles F Thomas, William D Travis, Yi-Long Wu
INTRODUCTION: An international database was collected to inform the 8 edition of the anatomic classification of lung cancer. The present analyses concern its primary tumor (T) component. METHODS: From 1999 to 2010, 77,156 evaluable patients, 70,967 with non-small-cell lung cancer, were collected; and 33,115 had either a clinical or a pathological classification, known tumor size, sufficient T information, and no metastases. Survival was measured from date of diagnosis or surgery for clinically and pathologically staged tumors...
July 2015: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/26110373/point-is-n2-disease-a-contraindication-for-surgical-resection-for-superior-sulcus-tumors-yes
#19
EDITORIAL
Nichole T Tanner, Gerard A Silvestri
No abstract text is available yet for this article.
December 2015: Chest
https://www.readbyqxmd.com/read/26059591/mdt-lung-cancer-care-input-from-the-surgical-oncologist
#20
REVIEW
Biniam Kidane, Shinichi Toyooka, Kazuhiro Yasufuku
Although there have been many advancements in the multidisciplinary management of non-small cell lung cancer (NSCLC), surgery remains the primary modality of choice for resectable lung cancer when the patient is able to tolerate lung resection physiologically. There have been recent advances in surgical diagnosis and treatment of lung cancer. Increasing use of low-dose computed tomography (CT) screening for lung cancer has resulted in increased detection of small peripheral nodules or semi-solid ground glass opacities...
October 2015: Respirology: Official Journal of the Asian Pacific Society of Respirology
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