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t4 lung cancer surgery

E Wakeam, S A Acuna, N B Leighl, M E Giuliani, S R G Finlayson, T K Varghese, G E Darling
BACKGROUND: The role of surgery in small cell lung cancer (SCLC) is controversial. Survival outcomes for resection of stage I-IIIA SCLC compared to chemotherapy-based non-surgical treatment (NST) were examined using propensity matching. METHODS: 29,994 clinical stage I-IIIA SCLC patients, including 2,619 undergoing surgery, were identified in the National Cancer Database. Stage-specific propensity scores for receipt of surgery were created. Resected patients were matched 1:1 to those undergoing NST...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
P G Dartevelle, D Mitilian, E Fadel
T4 non-small cell lung carcinomas (NSCLC) were deemed unresectable. Advances in surgery have challenged this dogma. We describe technical aspects and result on superior vena cava (SVC), carinal, thoracic inlet tumor surgeries, and resection under cardiopulmonary bypass (CPB). SVC reconstruction requires hemodynamic control to reverse SVC clamping cerebral effects and excellent cephalic venous bed patency. Among 50 SVC resections, including 25 carinal pneumonectomies, post-operative mortality rate was 8%. In the N0-N1 group, 5- and 10-year survival rates were 46...
March 27, 2017: General Thoracic and Cardiovascular Surgery
Paula Agostini, Sebastian T Lugg, Kerry Adams, Nelia Vartsaba, Maninder S Kalkat, Pala B Rajesh, Richard S Steyn, Babu Naidu, Alison Rushton, Ehab Bishay
OBJECTIVES: : Video-assisted thoracoscopic surgical (VATS) lobectomy is increasingly used for curative intent lung cancer surgery compared to open thoracotomy due to its minimally invasive approach and associated benefits. However, the effects of the VATS approach on postoperative pulmonary complications (PPC), rehabilitation and physiotherapy requirements are unclear; our study aimed to use propensity score matching to investigate this. METHODS: Between January 2012 and January 2016 all consecutive patients undergoing lobectomy via thoracotomy or VATS were prospectively observed...
June 1, 2017: Interactive Cardiovascular and Thoracic Surgery
Tomoya Yokota, Ken Kato, Yasuo Hamamoto, Yasuhiro Tsubosa, Hirofumi Ogawa, Yoshinori Ito, Hiroki Hara, Takashi Ura, Takashi Kojima, Keisho Chin, Shuichi Hironaka, Takayuki Kii, Yasushi Kojima, Yasunori Akutsu, Hisayuki Matsushita, Kentaro Kawakami, Keita Mori, Yushi Nagai, Chika Asami, Yuko Kitagawa
BACKGROUND: The standard treatment for locally advanced unresectable squamous cell carcinoma (SCC) of the oesophagus is chemoradiation with cisplatin and 5-fluorouracil (CF-RT). This multicentre phase II trial assessed the safety and efficacy of chemoselection with docetaxel plus cisplatin and 5-fluorouracil (DCF) induction chemotherapy (ICT) and subsequent conversion surgery (CS) for initially unresectable locally advanced SCC of the oesophagus. METHODS: Patients with clinical T4 and/or unresectable supraclavicular lymph node metastasis were eligible...
November 22, 2016: British Journal of Cancer
Femke S VAN DER Meer, Franz M N H Schramel, Marco VAN Vulpen, Sherif Y El Sharouni
BACKGROUND: In patients with non-small cell lung cancer (NSCLC), approximately 25% have locally advanced disease. For patients with irresectable (N2-3 or T4) or inoperable disease, treatment consists of chemoradiotherapy. Concomitant chemoradiotherapy improves survival compared to sequential chemoradiotherapy in these patients. PATIENTS AND METHODS: Treatment plans and completion of treatment was evaluated for all patients treated at the St. Antonius Hospital from 2008-2011 for NSCLC stage IIIA/B not eligible for surgery...
2016: Anticancer Research
Y S Zhang, H Y Yu, F Dong, H Z Li
OBJECTIVE: To explore how clinical features of renal cell carcinoma (RCC) relate to cancer patients' prognosis and survival. METHODS: A total of 1 497 renal cell carcinoma patients received surgical treatments in Department of Urology, Peking Union Medical College were admitted between January 2002 and December 2012. Telephone interviews and complimentary medical records review were carried out to acquire follow-up data, including post-surgery adjuvant therapy, disease progression and survival...
July 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Y T Cao, L Zhou, H T Wu, X M Li, W T Huang, X L Chen, C Li, L Tao
OBJECTIVE: To investigate the clinical characteristics, surgical treatment outcomes and prognostic factors of hypopharyngeal carcinoma. METHODS: A retrospective review of the Eye & ENT Hospital of Fudan University patients' database between January 2003 and June 2013 was conducted and a total of 386 patients were enrolled in the study. Patients' clinical and oncological information was collected and survival rates were analyzed using Kaplan-Meier curves. Prognostic factors were evaluated with multivariate Cox model survival analysis...
June 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Christos Asteriou, Achilleas Lazopoulos, Thomas Rallis, Apostolos S Gogakos, Dimitrios Paliouras, Kosmas Tsakiridis, Athanasios Zissimopoulos, Drosos Tsavlis, Konstantinos Porpodis, Wolfgang Hohenforst-Schmidt, Ioannis Kioumis, John Organtzis, Konstantinos Zarogoulidis, Paul Zarogoulidis, Nikolaos Barbetakis
BACKGROUND: Video-assisted thoracic surgery (VATS) has been shown to effectively reduce postoperative pain, enhance mobilization of the patients, shorten in-hospital length of stay, and minimize postoperative morbidity rates. The aim of this prospective study is to evaluate neuroendocrine and respiratory parameters as stress markers in cancer patients who underwent lung wedge resections, using both mini muscle-sparing thoracotomy and VATS approach. METHODS: The patients were randomly allocated into two groups: Group A (n=30) involved patients who were operated on using the VATS approach, while in group B (n=30), the mini muscle-sparing thoracotomy approach was used...
2016: Therapeutics and Clinical Risk Management
Chris Dickhoff, Max Dahele, A Joop de Langen, Marinus A Paul, Egbert F Smit, Suresh Senan, Koen J Hartemink, Ronald A Damhuis
INTRODUCTION: Current guidelines include both induction therapy plus an operation and chemoradiotherapy (CRT) as options for clinical stage IIIA (cIIIA) non-small cell lung cancer (NSCLC) after multidisciplinary evaluation. We explored the use of operations for cIIIA NSCLC in the Netherlands. METHODS: Data about the primary treatment of patients with cIIIA NSCLC (according to the seventh edition of the Tumour, Node, and Metastasis Classification of Malignant Tumours) between 2010 and 2013 were extracted from the Netherlands Cancer Registry...
April 2016: Journal of Thoracic Oncology
Myung Shin Kim, Eunsom Kim, Jeong-Seok Heo, Da-Jeong Bae, Jong-Uk Wook Lee, Tae-Hyeong Lee, Hyeon Ju Lee, Hun Soo Chang, Jong Sook Park, An Soo Jang, Eun Suk Koh, Hun Gyu Hwang, Guneil Lim, Soohyun Kim, Choon-Sik Park
OBJECTIVES: Interleukin (IL)-33 protects against infection and inflammation; however, few studies have explored the relevance of IL-33 in lung cancer patients. We evaluated relation of plasma IL-33 levels with development and progression of lung cancer. MATERIALS AND METHODS: A total of 160 patients with lung cancer and 160 controls with normal lungs were enrolled. Plasma IL-33 levels were measured using a specific sandwich ELISA; these levels were followed-up in 18 patients who underwent surgery and in 14 patients treated with chemotherapy...
November 2015: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Ramón Rami-Porta, Vanessa Bolejack, John Crowley, David Ball, Jhingook Kim, Gustavo Lyons, Thomas Rice, Kenji Suzuki, Charles F Thomas, William D Travis, Yi-Long Wu
INTRODUCTION: An international database was collected to inform the 8 edition of the anatomic classification of lung cancer. The present analyses concern its primary tumor (T) component. METHODS: From 1999 to 2010, 77,156 evaluable patients, 70,967 with non-small-cell lung cancer, were collected; and 33,115 had either a clinical or a pathological classification, known tumor size, sufficient T information, and no metastases. Survival was measured from date of diagnosis or surgery for clinically and pathologically staged tumors...
July 2015: Journal of Thoracic Oncology
Nichole T Tanner, Gerard A Silvestri
No abstract text is available yet for this article.
December 2015: Chest
Biniam Kidane, Shinichi Toyooka, Kazuhiro Yasufuku
Although there have been many advancements in the multidisciplinary management of non-small cell lung cancer (NSCLC), surgery remains the primary modality of choice for resectable lung cancer when the patient is able to tolerate lung resection physiologically. There have been recent advances in surgical diagnosis and treatment of lung cancer. Increasing use of low-dose computed tomography (CT) screening for lung cancer has resulted in increased detection of small peripheral nodules or semi-solid ground glass opacities...
October 2015: Respirology: Official Journal of the Asian Pacific Society of Respirology
Young Il Won, Chi Heon Kim, Chun Kee Chung, Tae Jin Yun
Occasionally, unexpected neurological deficits occur after lumbar spinal surgery. We report a case of monoparesis after lumbar decompressive surgery. A 63-year-old man, who had undergone decompression of L4-5 for spinal stenosis 4 days previously in the other hospital, visted the emergency department with progressive weakness in the left leg and hypoesthesia below sensory level T7 on the right side. He had been cured of lung cancer with chemotherapy and radiation therapy 10 years previously, but detailed information of radiotherapy was not available...
March 2015: Journal of Korean Neurosurgical Society
Safina Ali, Robert Bryant, Frank L Palmer, Monica DiLorenzo, Jatin P Shah, Snehal G Patel, Ian Ganly
BACKGROUND: This study aimed to show the incidence of distant metastases (DM) in salivary gland cancer as well as the types of histology most commonly associated with it and to identify factors predictive of DM. METHODS: The study identified 301 patients who underwent surgery for cancer of the major salivary glands at Memorial Sloan-Kettering Cancer center between 1985 and 2009. Clinical, tumor, and treatment characteristics were recorded. Tumors were categorized as low-, intermediate-, and high-risk pathology based on histologic subtype and grade...
November 2015: Annals of Surgical Oncology
Silvia da Silva Correia, Carlos Pinto, João Bernardo
INTRODUCTION: Carcinoid tumors of the lung are rare neoplasms of neuroendocrine origin. According to the World Health Organization, they can be classified into typical carcinoids and atypical carcinoids. The outcome, when compared to other lung neoplasms is usually favorable. OBJECTIVES: To characterize the population of patients with a diagnosis of carcinoid tumor, treated in a single institution and analyze the prognostic factors. MATERIAL AND METHODS: Retrospective analysis including all the patients with histological diagnosis of lung carcinoid tumor during an 11 year period, in a single institution...
November 2014: Acta Médica Portuguesa
J-R Guo, W Guo, X-J Jin, J Yu, B-W Jin, F Xu, Y Liu
OBJECTIVE: The aim of this study was to observe the effects of stellate ganglion block (SGB) on hemodynamic changes and intrapulmonary shunt during one-lung ventilation (OLV). PATIENTS AND METHODS: Thirty ASA class I-II patients undergoing elective esophageal surgery were randomly divided into two groups: general anesthesia group (group N, n=15) and general anesthesia combined SGB group (group S, n=15), patients in group S were received left SGB before induction...
2014: European Review for Medical and Pharmacological Sciences
M Smoragiewicz, J Laskin, D Wilson, K Ramsden, J Yee, S Lam, T Shaipanich, Y Zhai, C Ho
BACKGROUND: Combined positron-emission tomography and computed tomography (pet-ct) reduces futile thoracotomy (ft) rates in patients with non-small-cell lung cancer (nsclc). We sought to identify preoperative risk factors for ft in patients staged with pet-ct. METHODS: We retrospectively reviewed all patients referred to the BC Cancer Agency during 2009-2010 who underwent pet-ct and thoracotomy for nsclc. Patients with clinical N2 disease were excluded. An ft was defined as any of a benign lesion; an exploratory thoracotomy; pathologic N2 or N3, stage iiib or iv, or inoperable T3 or T4 disease; and recurrence or death within 1 year of surgery...
December 2014: Current Oncology
Ciprian Pricopi, Pierre Mordant, Caroline Rivera, Alex Arame, Christophe Foucault, Antoine Dujon, Françoise Le Pimpec Barthes, Marc Riquet
OBJECTIVES: We examined whether the changes in clinical practice with time correlated with the changes in the 90-day mortality following pneumonectomy. METHODS: The clinical records of consecutive patients undergoing pneumonectomy in two French centres from 1980 to 2009 were prospectively collected. The 90-day postoperative course was retrospectively studied according to clinical characteristics, underlying diseases, type of surgery and time-period (1980-1989; 1990-1999 or 2000-2009)...
March 2015: Interactive Cardiovascular and Thoracic Surgery
Emily S Reardon, David S Schrump
T4 tumors that invade the heart, great vessels, or esophagus comprise a heterogenous group of locally invasive lung cancers. Prognosis depends on nodal status; this relationship has been consistently demonstrated in many of the small series of extended resection. Current National Comprehensive Cancer Network guidelines do not recommend surgery for T4 extension with N2-3 disease (stage IIIB). However, biopsy-proven T4 N0-1 (stage IIIA) may be operable. Localized tumors with invasion of the aorta, pulmonary artery, left atrium, or esophagus represent a small subset of T4 disease...
November 2014: Thoracic Surgery Clinics
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