keyword
https://read.qxmd.com/read/38547409/long-term-rate-of-ventricular-arrhythmia-in-autoimmune-disease
#1
JOURNAL ARTICLE
Guoli Sun, Emil L Fosbøl, Morten Schou, Mikkel Faurschou, Adelina Yafasova, Jeppe K Petersen, Ketil J Haugan, Ulrik Madvig Mogensen, Jesper H Svendsen, Lars Køber, Jawad H Butt
AIMS: Although selected autoimmune diseases (AIDs) have been linked to an increased risk of ventricular arrhythmias (VAs), data on the long-term rate of VAs across the spectrum of AIDs are lacking. The aim of our study was to investigate the long-term rate of VAs (a composite of ventricular tachycardia, ventricular fibrillation, ventricular flutter, or cardiac arrest) in individuals with a history of 28 different AIDs. METHODS: Individuals diagnosed with an AID (2005-2018) were identified through Danish nationwide registries...
March 28, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38547042/high-reliability-pediatric-heart-centers-always-working-toward-getting-better
#2
JOURNAL ARTICLE
Andrea Torzone, Alexandra Birely
PURPOSE OF REVIEW: The purpose of this review is to examine high reliability through the lens of a contemporary pediatric heart center, noting that continuous improvement, rather than perfection, should be embraced. Aiming to elevate topics with lesser attention, this review elaborates on key concepts and proposed considerations for maintaining a high reliability heart center. RECENT FINDINGS: As provision of care reaches a new complexity, programs are called upon to evaluate how they can bring their teams into the future of pediatric cardiac care...
March 27, 2024: Current Opinion in Cardiology
https://read.qxmd.com/read/38546963/pentraxin-3-in-myocarditis-proof-of-principle-assessment-as-a-diagnostic-and-prognostic-biomarker
#3
JOURNAL ARTICLE
Andrea Villatore, Antonella Monno, Clara Sciorati, Patrizia Rovere-Querini, Simone Sala, Davide Carino, Michele De Bonis, Domenico Cianflone, Angelo A Manfredi, Giovanni Peretto
Pentraxin 3 (PTX3) is an acute phase protein produced in various tissues in response to microbial and sterile stimuli, which regulates the inflammation outcomes. PTX3 has not been investigated in myocarditis. Our aim was to assess circulating and cardiac tissue expression of PTX3 in 55 patients with myocarditis proven by magnetic resonance and/or endomyocardial biopsy. A major proportion of patients with myocarditis displayed significantly increased plasma PTX3 levels as compared with controls (26/30 vs. 0/10), with higher diagnostic yield than conventional biomarkers in the study group...
March 28, 2024: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/38546846/unveiling-cardiac-involvement-in-juvenile-dermatomyositis-through-speckle-tracking-echocardiography
#4
JOURNAL ARTICLE
Reyhan Dedeoglu, Nujin Ulug Murt, Aybüke Gunalp, Yusuf İskender Cosgun, Funda Oztunc, Savas Dedeoglu, Amra Adrovic, Sezgin Sahin, Mehmet Yıldız, Kenan Barut, Esma Aslan, Elif Kılıc Konte, Ümit Gul, Ozgur Kasapcopur
Early detection of cardiac involvement in Juvenile Dermatomyositis (JDM) is difficult due to the absence of clinical signs and symptoms, with systolic dysfunction often emerging in late stages and associated with a poor prognosis. This study aimed to employ two-dimensional speckle-tracking echocardiography (STE) for subclinical assessment of left ventricular (LV) systolic failure in JDM and explore potential associations between impaired LV systolic function (LV-GLS) and disease activity. A prospective study enrolled 20 healthy volunteers and 26 JDM patients (< 18 years old) without cardiac symptoms...
March 28, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38545554/effectiveness-and-safety-of-danshen-injections-in-treatment-of-cardiac-failure-a-network-meta-analysis
#5
REVIEW
Yuchen Song, Nan Song, Lianqun Jia, Yupeng Pei
Objective: The purpose of this network meta-analysis (NMA) was to compare the therapeutic effects of various Danshen ( Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma]) injections on heart failure to determine the optimal Danshen injection combined with conventional treatment. Methods: 8 databases were searched from the inception of these databases to May 2023 to collect randomized controlled trials (RCTs) on the effectiveness and safety of Danshen injections in the treatment of heart failure...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38545364/anomalous-origin-of-left-coronary-artery-from-the-pulmonary-artery-our-30-years-of-surgical-experience-and-outcomes
#6
JOURNAL ARTICLE
Chaganti Yogi Sundara Rao, A Aravind, Desai Nelam
Background: The aim of this study was to evaluate our 30 years of surgical experience and outcomes in management of anomalous origin of left coronary artery from the pulmonary artery with various age groups. Methods: Between March 1992 and August 2022, a total of 21 patients (10 males, 11 females; mean age: 16.3±15.9 years; range, 1 to 64 years) diagnosed with anomalous origin of left coronary artery from the pulmonary artery who underwent successful surgical repair were retrospectively analyzed. An initial diagnosis was made with two-dimensional echocardiography...
January 2024: Türk Göğüs Kalp Damar Cerrahisi Dergisi
https://read.qxmd.com/read/38544797/evaluation-of-all-cause-mortality-and-cardiovascular-safety-in-patients-receiving-chimeric-antigen-receptor-t-cell-therapy-a%C3%A2-prospective-cohort-study
#7
JOURNAL ARTICLE
Felix Korell, Lukas Entenmann, Sebastian Romann, Evangelos Giannitsis, Anita Schmitt, Carsten Müller-Tidow, Norbert Frey, Peter Dreger, Michael Schmitt, Lorenz H Lehmann
BACKGROUND: Assessment of cardiovascular risk is critical for patients with cancer. Previous retrospective studies suggest potential cardiotoxicity of CAR T cell therapies. We aimed to prospectively assess cardiotoxicity and the predictive value of cardiac biomarkers and classical risk factors (age, cardiac function, diabetes, arterial hypertension, smoking) for cardiac events and all-cause mortality (ACM). METHODS: In this prospective cohort study, all patients treated with CAR T cell constructs (axi-cel, tisa-cel, brexu-cel, ide-cel, or the 3rd generation CAR HD-CAR-1) from Oct 1, 2018, to Sept 30, 2022 at the University Hospital Heidelberg were included...
March 2024: EClinicalMedicine
https://read.qxmd.com/read/38544553/effect-of-plasma-exchange-with-albumin-replacement-on-albumin-functionality-and-organ-dysfunction-in-acute-on-chronic-liver-failure
#8
JOURNAL ARTICLE
Javier Fernández, Miquel Lozano, Mireia Torres, Raquel Horrillo, Natalia Afonso, Laura Núñez, Anna Mestre, Alba Pérez, Joan Cid, Montserrat Costa, Vicente Arroyo, Antonio Páez
BACKGROUND & AIMS: Effective treatments for acute-on-chronic liver failure (ACLF) are a major unmet need. This proof-of-concept pilot study was aimed at evaluating the effects of plasma exchange (PE) with albumin 5% (PE-A5%) on albumin functional capacity and organ dysfunction in patients with ACLF. METHODS: Ten adult patients were enrolled in a single-center phase II, prospective, open-label, non-controlled study. Six PE-A5% sessions were performed in 10 days followed by a 1-month follow-up visit...
April 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38544497/the-prognostic-value-of-collateral-circulation-in-coronary-chronic-total-occlusion-underwent-percutaneous-coronary-intervention
#9
JOURNAL ARTICLE
Xiao-Ying Hu, Wei-Xian Yang, Chang-Dong Guan, Li-Hua Xie, Ke-Fei Dou, Yong-Jian Wu, Jin-Qing Yuan, Jie Qian, Yue-Jin Yang, Shu-Bin Qiao, Lei Song
BACKGROUND: The prognostic value of coronary collateral circulation (CC) in patients undergoing chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is underdetermined. The purpose of the study was to assess the prognostic value of current two CC grading systems and their association with long-term outcomes in patients with CTO underwent PCI. METHODS: We consecutively enrolled patients with single-vessel CTO underwent PCI between January 2010 and December 2013...
February 28, 2024: Journal of Geriatric Cardiology: JGC
https://read.qxmd.com/read/38543180/real-world-safety-data-of-the-orphan-drug-onasemnogene-abeparvovec-zolgensma-%C3%A2-for-the-sma-rare-disease-a-pharmacovigilance-study-based-on-the-ema-adverse-event-reporting-system
#10
JOURNAL ARTICLE
Rosanna Ruggiero, Nunzia Balzano, Maria Maddalena Nicoletti, Gabriella di Mauro, Federica Fraenza, Maria Rosaria Campitiello, Francesco Rossi, Annalisa Capuano
The recent introduction of the innovative therapy, onasemnogene abeparvovec (Zolgensma® ), has revolutionized the spinal muscular atrophy (SMA) therapeutic landscape. Although Zolgensma® therapy has proven to lead to functional improvements in SMA children, some gaps in its safety profile still need to be investigated. To better characterize the Zolgensma® safety profile, we conducted a retrospective observational study, analyzing all the Individual Case Safety Reports (ICSRs) referred to it and collected in the European pharmacovigilance database between 1 January 2019 and 22 September 2023...
March 19, 2024: Pharmaceuticals
https://read.qxmd.com/read/38543053/hitting-the-target-challenges-and-opportunities-for-tgf-%C3%AE-inhibition-for-the-treatment-of-cardiac-fibrosis
#11
REVIEW
Maria Vistnes
Developing effective anti-fibrotic therapies for heart diseases holds the potential to address unmet needs in several cardiac conditions, including heart failure with preserved ejection fraction, hypertrophic cardiomyopathy, and cardiotoxicity induced by cancer therapy. The inhibition of the primary fibrotic regulator, transforming growth factor (TGF) β, represents an efficient strategy for mitigating fibrosis in preclinical models. However, translating these findings into clinical benefits faces challenges due to potential adverse effects stemming from TGF-β's physiological actions in inflammation and tissue homeostasis...
February 20, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542836/the-roles-of-exosome-derived-micrornas-in-cardiac-fibrosis
#12
REVIEW
Xinyuan Tang, Mingyang Leng, Wenyue Tang, Zhenlu Cai, Lin Yang, Liang Wang, Yue Zhang, Jiao Guo
Cardiovascular disease (CVD) stands as the foremost cause of patient mortality, and the lack of early diagnosis and defined treatment targets significantly contributes to the suboptimal prevention and management of CVD. Myocardial fibrosis (MF) is not only a complex pathogenic process with no effective treatment currently available but also exerts detrimental effects on the progression of various cardiovascular diseases, thereby escalating their mortality rates. Exosomes are nanoscale biocommunication vehicles that facilitate intercellular communication by transporting bioactive substances, such as nucleic acids and proteins, from specific cell types...
March 7, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542290/nbutgt-reinforces-the-beneficial-effects-of-epinephrine-on-cardiac-mitochondrial-respiration-lactatemia-and-cardiac-output-in-experimental-anaphylactic-shock
#13
JOURNAL ARTICLE
Walid Oulehri, Antoine Persello, Angelique Blangy-Letheule, Charles Tacquard, Bertrand Rozec, Anne-Laure Charles, Bernard Geny, Benjamin Lauzier, Paul Michel Mertes, Olivier Collange
Anaphylactic shock (AS) is the most severe form of acute systemic hypersensitivity reaction. Although epinephrine can restore patients' hemodynamics, it might also be harmful, supporting the need for adjuvant treatment. We therefore investigated whether NButGT, enhancing O-GlcNAcylation and showing beneficial effects in acute heart failure might improve AS therapy. Ovalbumin-sensitized rats were randomly allocated to six groups: control (CON), shock (AS), shock treated with NButGT alone before (AS+pre-Nbut) or after (AS+post-Nbut) AS onset, shock treated with epinephrine alone (AS+EPI) and shock group treated with combination of epinephrine and NButGT (AS+EPI+preNBut)...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542257/connexin43-a-promising-target-to-reduce-cardiac-arrhythmia-burden-in-pulmonary-arterial-hypertension
#14
REVIEW
Matus Sykora, Barbara Szeiffova Bacova, Katarina Andelova, Tamara Egan Benova, Adriana Martiskova, Lin-Hai Kurahara, Katsuya Hirano, Narcis Tribulova
While essential hypertension (HTN) is very prevalent, pulmonary arterial hypertension (PAH) is very rare in the general population. However, due to progressive heart failure, prognoses and survival rates are much worse in PAH. Patients with PAH are at a higher risk of developing supraventricular arrhythmias and malignant ventricular arrhythmias. The latter underlie sudden cardiac death regardless of the mechanical cardiac dysfunction. Systemic chronic inflammation and oxidative stress are causal factors that increase the risk of the occurrence of cardiac arrhythmias in hypertension...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542242/microcurrent-mediated-modulation-of-myofibroblasts-for-cardiac-repair-and-regeneration
#15
JOURNAL ARTICLE
Dipthi Bachamanda Somesh, Karsten Jürchott, Thomas Giesel, Thomas Töllner, Alexander Prehn, Jan-Peter Richters, Dragana Kosevic, Jesus Eduardo Rame, Peter Göttel, Johannes Müller
Cardiovascular diseases are a significant cause of illness and death worldwide, often resulting in myofibroblast differentiation, pathological remodeling, and fibrosis, characterized by excessive extracellular matrix protein deposition. Treatment options for cardiac fibrosis that can effectively target myofibroblast activation and ECM deposition are limited, necessitating an unmet need for new therapeutic approaches. In recent years, microcurrent therapy has demonstrated promising therapeutic effects, showcasing its translational potential in cardiac care...
March 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541967/evaluation-of-serum-myostatin-concentration-in-chronic-heart-failure-with-preserved-and-impaired-left-ventricular-ejection-fraction
#16
JOURNAL ARTICLE
Jan Bączek, Mirosław Charkiewicz, Agnieszka Kasiukiewicz, Anna Maria Witkowska, Łukasz Magnuszewski, Marta Bączek, Zyta Beata Wojszel
Background: Chronic heart failure (CHF) is a complex clinical syndrome associated with muscle wasting, which can progress to cardiac cachexia. Myostatin, a negative regulator of muscle growth, has been implicated in the pathophysiology of muscle wasting in CHF patients and suggested as a potential biomarker. The objective of this study was to investigate serum myostatin concentration in patients with CHF with preserved and reduced ejection fraction. Methods: The authors conducted a single-centre study comparing serum myostatin levels, functional and echocardiographic parameters, muscle mass, strength and function in patients with CHF to a control group without CHF...
March 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541902/clinical-characteristics-and-incidence-of-hemorrhagic-complications-in-patients-taking-factor-xa-inhibitors-in-spain-a-long-term-observational-study
#17
JOURNAL ARTICLE
Carlos Escobar, Beatriz Palacios, Miriam Villarreal, Martín Gutiérrez, Margarita Capel, Ignacio Hernández, María García, Laura Lledó, Juan F Arenillas
Objective. To analyze the clinical characteristics of patients taking Factor Xa inhibitors (FXai), either direct FXai or enoxaparin (only in active cancer patients), and to estimate the incidence of and risk factors for major bleeding during FXai use. Methods. A retrospective cohort study, which included secondary data from computerized health records of primary care centers and hospitals in seven Spanish Autonomous Communities. Results. 9374 patients were analyzed, with 8972 taking direct FXai and 402 enoxaparin...
March 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541896/systemic-vascular-resistance-and-myocardial-work-analysis-in-hypertrophic-cardiomyopathy-and-transthyretin-cardiac-amyloidosis-with-preserved-left-ventricular-ejection-fraction
#18
JOURNAL ARTICLE
Cesare de Gregorio, Giancarlo Trimarchi, Denise Cristiana Faro, Cristina Poleggi, Lucio Teresi, Fabrizio De Gaetano, Concetta Zito, Francesca Lofrumento, Ioanna Koniari, Roberto Licordari, Nicholas G Kounis, Ines Paola Monte, Gianluca Di Bella
Background : The pathophysiological impact of systemic vascular resistance (SVR) and pressure-strain loop-derived global myocardial work index (GWI) in hypertrophic cardiomyopathy (HCM) and transthyretin cardiac amyloidosis (ATTR) has been randomly investigated. Methods : Both SVR and GWI were assessed in outpatients consecutively referred at two Italian cardiology departments for heart failure with preserved left ventricular ejection fraction (LVEF), affected by either nonobstructive HCM or wild-type ATTR...
March 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541846/echocardiography-and-cardiac-magnetic-resonance-in-the-assessment-of-left-ventricle-remodeling-differences-implying-clinical-decision
#19
JOURNAL ARTICLE
Maciej Haberka, Monika Starzak, Grzegorz Smolka, Wojciech Wojakowski, Zbigniew Gąsior
Introduction : Transthoracic echocardiography (TTE) and cardiovascular magnetic resonance (CMR) are the most important modalities used in clinical practice to assess cardiac chambers. However, different imaging techniques may affect their results and conclusions. The aim of our study was to compare left-ventricle (LV) remodeling assessed using TTE and CMR in the context of various cardiovascular diseases. Methods : A total of 202 consecutive patients sent for an elective cardiovascular diagnosis were scheduled for a 2D TTE and CMR, performed within 2 weeks...
March 12, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541799/unlocking-diagnostic-precision-fate-protocol-integration-with-blue-and-efast-protocols-for-enhanced-pre-hospital-differential-diagnosis-of-pleural-effusion-manifested-as-dyspnea-in-adults-a-pilot-study
#20
JOURNAL ARTICLE
Damian Kowalczyk, Miłosz Turkowiak, Wojciech Jerzy Piotrowski, Oskar Rosiak, Adam Jerzy Białas
Background : Dyspnea commonly stems from combined myocardial and pulmonary dysfunction, posing challenges for accurate pre-hospital diagnosis. Limited diagnostic capabilities hinder the differentiation of cardiac and pulmonary issues. This study assesses the efficacy of combined cardiac and pulmonary ultrasound using the BLUE, eFAST, and FATE protocols. Methods : Participants were consecutively enrolled from dyspnea-related emergency calls in Warsaw, Poland, from 4 April 2022, to 15 June 2023. Patients with pleural effusion were identified through pre-hospital and in-hospital radiological assessments...
March 9, 2024: Journal of Clinical Medicine
keyword
keyword
76178
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.