Sungjin Min, Suran Kim, Woo-Sup Sim, Yi Sun Choi, Hyebin Joo, Jae-Hyun Park, Su-Jin Lee, Hyeok Kim, Mi Jeong Lee, Inhea Jeong, Baofang Cui, Sung-Hyun Jo, Jin-Ju Kim, Seok Beom Hong, Yeon-Jik Choi, Kiwon Ban, Yun-Gon Kim, Jang-Ung Park, Hyang-Ae Lee, Hun-Jun Park, Seung-Woo Cho
Engineered human cardiac tissues have been utilized for various biomedical applications, including drug testing, disease modeling, and regenerative medicine. However, the applications of cardiac tissues derived from human pluripotent stem cells are often limited due to their immaturity and lack of functionality. Therefore, in this study, we establish a perfusable culture system based on in vivo-like heart microenvironments to improve human cardiac tissue fabrication. The integrated culture platform of a microfluidic chip and a three-dimensional heart extracellular matrix enhances human cardiac tissue development and their structural and functional maturation...
March 22, 2024: Nature Communications