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Manuela Casula, Lorenza Scotti, Elena Tragni, Luca Merlino, Giovanni Corrao, Alberico L Catapano
BACKGROUND AND AIMS: We aimed at describing the therapeutic approach in young adult patients diagnosed with heterozygous familial hypercholesterolemia (HeFH) and their adherence and persistence to treatment. METHODS: From regional administrative databases, individuals aged ≤40 years, who received exemption for HeFH between January 1, 2003 and December 31, 2011, and concomitantly started statin treatment, were identified. Within the first year of treatment, we evaluated therapeutic changes, adherence as MPR (medication possession ratio), persistence as continuous drug coverage without gaps ≥60 days, and influencing factors using log binomial models...
October 12, 2016: Atherosclerosis
Deborah Sylvester, Rishi Srivastava, Archie Lamplugh, Victoria Allgar, Chris Snowden, Sunil Bhandari, James England
Hyperparathyroidism attributed to chronic renal failure contributes significantly to morbidity and mortality. In our 103 parathyroidectomy patients matched to 1404 non-surgical patients, long-term mortality was reduced. This difference could not be attributed to differences in age, sex, time on renal replacement therapy or co-morbidities between the groups. This article is protected by copyright. All rights reserved.
October 11, 2016: Clinical Otolaryngology
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Chest
Ali Afshar-Oromieh, John W Babich, Clemens Kratochwil, Frederik L Giesel, Michael Eisenhut, Klaus Kopka, Uwe Haberkorn
The prostate-specific membrane antigen (PSMA) has received increased consideration during the past few years as an excellent target for both imaging and therapy of prostate cancer. After many years of outstanding preclinical research, the first significant step forward in clinical use was achieved in 2008 with the first human experience with the small-molecule PSMA inhibitors (123)I-MIP-1972 and (123)I-MIP-1095. A clinical breakthrough followed in 2011 with (68)Ga-PSMA-11 for PET imaging and (131)I-MIP-1095 for endoradiotherapy of metastatic prostate cancer...
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
M Daniel, N Rudenko, M Golovchenko, V Danielová, A Fialová, B Kříž, M Malý
STUDY OBJECTIVE: Three years long research study (2011-2013) on population density of Ixodes ricinus and the infection rate of the pathogens that they transmit was conducted in four topographically distant areas in the Czech Republic. In the previous decade (2001-2010) thirteen loci with increased incidence of tick borne encephalitis cases were defined, suggesting the permanent interaction of human population with ticks and indicating the landmarks for study of the presence of other tick borne pathogens...
2016: Epidemiologie, Mikrobiologie, Imunologie
Su-Li Ren, Yi-Han Li, Ya-Ting Zhou, Wei-Ming Xu, Andrew G S Cuthbertson, Yan-Jun Guo, Bao-Li Qiu
AIMS: The Asian citrus psyllid (ACP), Diaphorina citri Kuwayama transmits the bacterium 'Candidatus Liberibacter asiaticus' (Las), which causes citrus huanglongbing (HLB) disease. Although many studies have been conducted on the biology of ACP on different host plant, few have taken the plant, Las bacteria and the vector insect within one context to evaluate the effects of Las on the fitness of ACP under field conditions. Understanding the relationship between Las and ACP is critical for both ACP and HLB disease management...
September 26, 2016: Journal of Applied Microbiology
Marian A Nkansah, Francis Opoku, James H Ephraim, David D Wemegah, Luke P M Tetteh
Due to the increase in students' population over the years, the Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana, and its surrounding communities have seen an increase in the number of beauty salons. The assessment of the quality of salon wastewater has received little attention, as a potential source of environmental and public health hazard, due to the lack of literature on this issue. The main aim of this study is to assess wastewater effluent characteristics in KNUST and its surrounding areas, in relation to its physicochemical and microbial parameters...
2016: Environmental Health Insights
Ram N Singh, Sonam Gaba, Ajar N Yadav, Prakhar Gaur, Sneha Gulati, Rajeev Kaushik, Anil K Saxena
Arthrobacter agilis strain L77, is a plant growth promoting and cold active hydrolytic enzymes producing psychrotrophic bacterium, isolated from Pangong Lake, a subglacial lake in north western Himalayas, India. Genome analysis revealed metabolic versatility with genes involved in metabolism and cold shock adaptation, utilization and biosynthesis of diverse structural and storage polysaccharides such as plant based carbon polymers. The genome of Arthrobacter agilis strain L77 consists of 3,608,439 bp (3.60 Mb) of a circular chromosome...
2016: Standards in Genomic Sciences
Sahar Dehdari, Homa Hajimehdipoor
BACKGROUND: Leucorrhea or vaginal discharge is a conventional complaint. It is generally whitish, yellowish, or greenish vaginal discharge in females that might be normal or a symptom of infection. It is almost mucus discharge, which exhibit exfoliation of vaginal epithelial cells due to estrogen influence on the vaginal mucosa. It is important to identify the differences between physiologic and pathologic discharges. Leucorrhea is a well-known disease in Iranian traditional medicine (ITM)...
May 2016: Iranian Journal of Medical Sciences
J W Cui, J A Hu, L Zhu
OBJECTIVE: To know the incidence and survival rate of patients with pneumoconiosis in Yueyang and investigate the related factors of death hazard ratio. METHODS: A total; of 1404 patients with pneumoconiosis were diagnosed and reported from 1963.1-2014.12. Log Rank method and Cox regression model were used to make the survival analysis. RESULTS: The case fatality rate of pneumoconiosis was 24.57%,and rose with the increase of pneumoconiosis stage, the average course of disease was (14...
May 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Andrei L Lomize, Mikhail A Lomize, Shean R Krolicki, Irina D Pogozheva
The Membranome database was developed to assist analysis and computational modeling of single-pass (bitopic) transmembrane (TM) proteins and their complexes by providing structural information about these proteins on a genomic scale. The database currently collects data on >6000 bitopic proteins from Homo sapiens, Arabidopsis thaliana, Dictyostelium discoideum, Saccharomyces cerevisiae, Escherichia coli and Methanocaldococcus jannaschii It presents the following data: (i) hierarchical classification of bitopic proteins into 15 functional classes, 689 structural superfamilies and 1404 families; (ii) 446 complexes of bitopic proteins with known three-dimensional (3D) structures classified into 129 families; (iii) computationally generated three-dimensional models of TM α-helices positioned in membranes; (iv) amino acid sequences, domain architecture, functional annotation and available experimental structures of bitopic proteins; (v) TM topology and intracellular localization, (vi) physical interactions between proteins from the database along with links to other resources...
August 10, 2016: Nucleic Acids Research
Kara Bickham, Alan J Kivitz, Anish Mehta, Nancy Frontera, Sandhya Shah, Paul Stryszak, Zoran Popmihajlov, Paul M Peloso
BACKGROUND: Treatment with non-steroidal anti-inflammatory drugs (NSAID) is a common component of treatment regimens for rheumatoid arthritis (RA). Etoricoxib is a COX-2 selective NSAID that has demonstrated efficacy in the treatment of RA at a dose of 90 mg. The current study further evaluated the efficacy of etoricoxib 60 mg and 90 mg in RA patients with active disease. METHODS: This was a 2-part, double-blind, placebo-controlled study in RA (NCT01208181). Patients were required to have a diagnosis of RA (according to ARA 1987 revised classification criteria) and were to demonstrate symptom flare upon discontinuation of previous NSAID treatment prior to randomization...
2016: BMC Musculoskeletal Disorders
Anouar Teriaky, Abdullah AlNasser, Carolyn McLean, James Gregor, Brian Yan
Background and Aims. Upper endoscopy is a valuable tool in the workup of gastrointestinal (GI) complaints. The purpose of this study is to determine cost and yield of taking biopsies in a normal upper GI tract. Methods. This is a retrospective study where all upper GI biopsies were identified between May 2012 and April 2013, at a tertiary care center. Clinical, procedural, and pathology reports were reviewed to identify patient demographics, procedure information, and pathology diagnosis. Results. Biopsies of the upper GI tract were taken in 1297 patients with normal upper endoscopies...
2016: Canadian Journal of Gastroenterology & Hepatology
Caroline Schmidt Laugesen, Christoffer Ostri, Troels Brynskov, Henrik Lund-Andersen, Michael Larsen, Henrik Vorum, Torben L Sørensen
PURPOSE: There is little information about the efficacy of intravitreal vascular endothelial growth factor (VEGF) inhibition in vitrectomized eyes. This study aimed to evaluate the efficacy of anti-VEGF (ranibizumab) on diabetic macular oedema in previously vitrectomized eyes. METHODS: A nationwide retrospective review of medical records from 2010 to 2013. RESULTS: We identified 33 previously vitrectomized eyes in 28 patients treated with ranibizumab injections for diabetic macular oedema...
July 30, 2016: Acta Ophthalmologica
Billie K Alba, Anna E Stanhewicz, W Larry Kenney, Lacy M Alexander
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Timothy Jeffery, Rodney Petersen, Julie Quinlivan
BACKGROUND: Controversy surrounds the role of fetal cardiotocography (CTG) in the antenatal management of pregnancy complicated with gestational diabetes mellitus (GDM). AIM: The aim was to investigate whether antenatal CTG aids management in pregnancy complicated by GDM. MATERIALS AND METHODS: A prospective audit of 1404 consecutive antenatal CTG in women diagnosed with GDM. Outcomes for all CTG were audited to determine whether CTG altered pregnancy management...
August 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
Rajat Buragohain
AIM: The study was for assessment of growth performance, nutrient utilization, and feed efficiency in broilers fed rations with varying levels of Tithonia diversifolia leaf meal (TDLM) as a substitute of conventional feed ingredients in Mizoram. MATERIALS AND METHODS: A total of 180, 1-day-old broiler chicks were randomly divided into six homogeneous groups and fed rations incorporated with TDLM (TDLM at 0% [TDLM-0], 2% [TDLM-2], 4% [TDLM-4], 6% [TDLM-6], 8% [TDLM-8], and 10% [TDLM-10] level as substitute of conventional feed ingredients) for 6 weeks...
May 2016: Veterinary World
Affan Umer, David S Shapiro, Chris Hughes, Cynthia Ross-Richardson, Scott Ellner
BACKGROUND: Catheter-associated urinary tract infections (CAUTI) have been associated with increases in morbidity and mortality as well as increased costs of hospitalization. At our institution, we implemented a protocol for indwelling catheter use, maintenance, and removal based on Center for Medicare and Medicaid Services (CMS) guidelines, in efforts to reduce CAUTI rates. METHODS: A hospital committee of quality stewards focused on several measures which included staff education, modification of existing systems to ensure compliance, and auditing of patient care areas for catheter utilization before implementation of the protocol...
April 2016: Connecticut Medicine
Laura L Blaisdell, Jennifer A Zellner, Alison A King, Elaine Faustman, Mari Wilhelm, Mark L Hudak, Robert D Annett
OBJECTIVES: Ten National Children's Study (NCS) study locations with diverse demographic characteristics used an enhanced household-based recruitment (EHBR) approach to enroll preconceptional and pregnant women. Study centers used different types and dosages of community outreach and engagement (COE) activities and supplemental strategies. The goal of the study was to determine whether variability in enumeration and recruitment outcomes correlated with study location characteristics or types and dosages of COE activities (number of COE events, number of advance household mailings, total media expenditures, and total COE expenditures)...
June 2016: Pediatrics
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