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https://www.readbyqxmd.com/read/29916921/assessment-of-treatment-response-by-99mtc-mip-1404-spect-ct-a-pilot-study-in-patients-with-metastatic-prostate-cancer
#1
Christian Schmidkonz, Michael Cordes, Michael Beck, Theresa Ida Goetz, Daniela Schmidt, Olaf Prante, Tobias Bäuerle, Alexander Cavallaro, Michael Uder, Bernd Wullich, Peter Goebell, Torsten Kuwert, Philipp Ritt
BACKGROUND: We investigated the role of Tc-MIP-1404 (Progenics Pharmaceuticals, Inc, New York, NY) SPECT/CT of PSMA expression in the assessment of treatment response in patients with metastatic prostate cancer. METHODS: We retrospectively analyzed Tc-MIP-1404 SPECT/CT scans from 28 patients with metastatic prostate cancer examined before initiation and after completion of therapy. Eight of these patients had been treated with androgen deprivation therapy, 10 with docetaxel, and another 10 with external beam radiotherapy...
June 19, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29910824/development-of-species-specific-scar-markers-based-on-a-scot-analysis-to-authenticate-physalis-solanaceae-species
#2
Shangguo Feng, Yujia Zhu, Chenliang Yu, Kaili Jiao, Mengying Jiang, Jiangjie Lu, Chenjia Shen, Qicai Ying, Huizhong Wang
Physalis is an important genus in the Solanaceae family. It includes many species of significant medicinal value, edible value, and ornamental value. However, many Physalis species are easily confused because of their similar morphological traits, which hinder the utilization and protection of Physalis resources. Therefore, it is necessary to create fast, sensitive, and reliable methods for the Physalis species authentication. Intended for that, in this study, species-specific sequence-characterized amplified region (SCAR) markers were developed for accurate identification of the closely related Physalis species P...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29864216/continuous-intravenous-perioperative-lidocaine-infusion-for-postoperative-pain-and-recovery-in-adults
#3
REVIEW
Stephanie Weibel, Yvonne Jelting, Nathan L Pace, Antonia Helf, Leopold Hj Eberhart, Klaus Hahnenkamp, Markus W Hollmann, Daniel M Poepping, Alexander Schnabel, Peter Kranke
BACKGROUND: The management of postoperative pain and recovery is still unsatisfactory in a number of cases in clinical practice. Opioids used for postoperative analgesia are frequently associated with adverse effects, including nausea and constipation, preventing smooth postoperative recovery. Not all patients are suitable for, and benefit from, epidural analgesia that is used to improve postoperative recovery. The non-opioid, lidocaine, was investigated in several studies for its use in multimodal management strategies to reduce postoperative pain and enhance recovery...
June 4, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29802586/type-2-diabetes-detection-based-on-serum-sample-raman-spectroscopy
#4
J L González-Solís, J R Villafan-Bernal, B E Martínez-Zérega, S Sánchez-Enríquez
In this work, we propose to the Raman spectroscopy as a new technique for the detection of the type 2 diabetes using blood serum samples. The serum samples were obtained from 15 patients who were clinically diagnosed with type 2 diabetes mellitus and 20 healthy volunteers. The average spectra showed equally intense peaks as, 695 cm-1 , the doublet of tyrosine at 828 and 853 cm-1 , phenylalanine at 1002 and 1028 cm-1 , the phospholipid shoulder at 1300-1345 cm-1 , and proteins (amide I) at 1654 cm-1 . The major differences were found at 661 and 1404 cm-1 (glutathione), 714 (polysaccharides), 605 (Phe), 545 cm-1 (tryptophan), and the shoulder of amide III at 1230-1282 cm-1 , where seem to disappear in the diabetes spectrum...
May 25, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29776836/analysis-of-incidence-of-traumatic-brain-injury-in-blunt-trauma-patients-with-glasgow-coma-scale-of-12-or-less
#5
Alexander Becker, Kobi Peleg, Oded Olsha, Adi Givon, Boris Kessel
PURPOSE: Early diagnosis of traumatic brain injury (TBI) is important for improving survival and neurologic outcome in trauma victims. The purpose of this study was to assess whether Glasgow Coma Scale (GCS) of 12 or less can predict the presence of TBI and the severity of associated injuries in blunt trauma patients. METHODS: A retrospective cohort study including 303,435 blunt trauma patients who were transferred from the scene to hospital from 1998 to 2013. The data was obtained from the records of the National Trauma Registry maintained by Israel's National Center for Trauma and Emergency Medicine Research, in the Gertner Institute for Epidemiology and Health Policy Research...
April 16, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29769605/sex-difference-in-bone-architecture-and-bone-fragility-in-vietnamese
#6
Lan T Ho-Pham, Thao P Ho-Le, Linh D Mai, Tam M Do, Minh C Doan, Tuan V Nguyen
This study sought to define the sex-difference in trabecular and cortical bone parameters in Vietnamese individuals. The study involved 1404 women and 864 men aged between 20 and 86 years who were recruited from Ho Chi Minh City, Vietnam. Trabecular and cortical volumetric BMD were measured at the proximal tibia and proximal radius at 4%, 38%, and 66% points, using a peripheral quantitative computed tomography XCT2000 (Stratec, Germany). Polar strength strain index was estimated from cortical bone parameters...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29730637/comparative-effectiveness-of-tocilizumab-versus-tnf-inhibitors-as-monotherapy-or-in-combination-with-conventional-synthetic-disease-modifying-antirheumatic-drugs-in-patients-with-rheumatoid-arthritis-after-the-use-of-at-least-one-biologic-disease-modifying
#7
Kim Lauper, Dan C Nordström, Karel Pavelka, Maria Victoria Hernández, Tore K Kvien, Eirik Klami Kristianslund, Maria Jose Santos, Žiga Rotar, Florenzo Iannone, Catalin Codreanu, Galina Lukina, Sara L Gale, Khaled Sarsour, Yves Luder, Delphine Sophie Courvoisier, Cem Gabay
OBJECTIVE: To compare the effectiveness of tocilizumab (TCZ) and tumour necrosis factor (TNF) inhibitors (TNFi) as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) after the use of at least one biologic DMARD (bDMARD). METHODS: We included patients with RA having used at least one bDMARD from 10 European registries. We compared drug retention using Kaplan-Meier and Cox models and Clinical Disease Activity Index (CDAI) change over time with mixed-effects models for longitudinal data...
May 5, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29722857/procedural-and-long-term-outcome-after-catheter-ablation-of-idiopathic-outflow-tract-ventricular-arrhythmias-comparing-manual-contact-force-and-magnetic-navigated-ablation
#8
Lennart J de Vries, Astrid A Hendriks, Sing C Yap, Dominic A M J Theuns, Ron T van Domburg, Tamas Szili-Torok
Aims: Currently, comparative data on procedural and long-term clinical outcome of outflow tract (OT) idiopathic ventricular arrhythmia (IVA) ablation with manual (MAN), contact force (CF), and magnetic navigation system (MNS) ablation are lacking. The aim of this study was to compare the procedural and long-term clinical outcome of MAN, CF, and MNS ablation of OT IVAs. Methods and results: Seventy-three patients (31 MAN, 17 CF, and 25 MNS patients; consecutive per group) with OT IVA, who underwent catheter ablation in our centre were analysed...
May 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29594154/a-systems-approach-to-evaluate-one-health-initiatives
#9
Simon R Rüegg, Liza Rosenbaum Nielsen, Sandra C Buttigieg, Mijalche Santa, Maurizio Aragrande, Massimo Canali, Timothy Ehlinger, Ilias Chantziaras, Elena Boriani, Miroslav Radeski, Mieghan Bruce, Kevin Queenan, Barbara Häsler
Challenges calling for integrated approaches to health, such as the One Health (OH) approach, typically arise from the intertwined spheres of humans, animals, and ecosystems constituting their environment. Initiatives addressing such wicked problems commonly consist of complex structures and dynamics. As a result of the EU COST Action (TD 1404) "Network for Evaluation of One Health" (NEOH), we propose an evaluation framework anchored in systems theory to address the intrinsic complexity of OH initiatives and regard them as subsystems of the context within which they operate...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29555910/analysis-of-microrna-and-gene-expression-profiles-in-alzheimer-s-disease-a-meta-analysis-approach
#10
Shirin Moradifard, Moslem Hoseinbeyki, Shahla Mohammad Ganji, Zarrin Minuchehr
Understanding the molecular mechanisms underlying Alzheimer's disease (AD) is necessary for the diagnosis and treatment of this neurodegenerative disorder. It is therefore important to detect the most important genes and miRNAs, which are associated with molecular events, and studying their interactions for recognition of AD mechanisms. Here we focus on the genes and miRNAs expression profile, which we have detected the miRNA target genes involved in AD. These are the most quintessential to find the most important miRNA, to target genes and their important pathways...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29546639/beetroot-supplementation-improves-the-physiological-responses-to-incline-walking
#11
Mark Waldron, Luke Waldron, Craig Lawlor, Adrian Gray, Jamie Highton
PURPOSE: We investigated the effects of an acute 24-h nitrate-rich beetroot juice supplement (BR) on the energy cost, exercise efficiency and blood pressure responses to intermittent walking at different gradients. METHODS: In a double-blind, cross-over design, eight participants were provided with a total of 350 ml of nitrate-rich (~ 20.5 mmol nitrate) BR or placebo (PLA) across 24 h before completing intermittent walking at 3 km/h on treadmill at gradients of 1, 5, 10, 15 and 20%...
March 15, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29518269/viral-etiologies-of-influenza-like-illness-and-severe-acute-respiratory-infections-in-thailand
#12
Malinee Chittaganpitch, Sunthareeya Waicharoen, Thitipong Yingyong, Prabda Praphasiri, Somchai Sangkitporn, Sonja J Olsen, Kim A Lindblade
BACKGROUND: Information on the burden, characteristics and seasonality of non-influenza respiratory viruses is limited in tropical countries. OBJECTIVES: Describe the epidemiology of selected non-influenza respiratory viruses in Thailand between June 2010 and May 2014 using a sentinel surveillance platform established for influenza. METHODS: Patients with influenza-like illness (ILI; history of fever or documented temperature ≥38°C, cough, not requiring hospitalization) or severe acute respiratory infection (SARI; history of fever or documented temperature ≥38°C, cough, onset <10 days, requiring hospitalization) were enrolled from 10 sites...
March 8, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29513054/influence-of-inter-observer-delineation-variability-on-radiomics-stability-in-different-tumor-sites
#13
Matea Pavic, Marta Bogowicz, Xaver Würms, Stefan Glatz, Tobias Finazzi, Oliver Riesterer, Johannes Roesch, Leonie Rudofsky, Martina Friess, Patrick Veit-Haibach, Martin Huellner, Isabelle Opitz, Walter Weder, Thomas Frauenfelder, Matthias Guckenberger, Stephanie Tanadini-Lang
BACKGROUND: Radiomics is a promising methodology for quantitative analysis and description of radiological images using advanced mathematics and statistics. Tumor delineation, which is still often done manually, is an essential step in radiomics, however, inter-observer variability is a well-known uncertainty in radiation oncology. This study investigated the impact of inter-observer variability (IOV) in manual tumor delineation on the reliability of radiomic features (RF). METHODS: Three different tumor types (head and neck squamous cell carcinoma (HNSCC), malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC)) were included...
March 7, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29510502/toxicity-of-beauveria-bassiana-28-mycelial-extracts-on-larvae-of-culex-quinquefasciatus-mosquito-diptera-culicidae
#14
Perumal Vivekanandhan, Thangaraj Kavitha, Sengodan Karthi, Sengottayan Senthil-Nathan, Muthugoundar Subramanian Shivakumar
Microbial-based pest control is an attractive alternative to chemical insecticides. The present study sought to evaluate the toxicity of the entomopathogenic fungus Beauveria bassiana -28 ethyl acetate extracts on different larval stages and pupae of Culex quinquefasciatus mosquitoes. B. bassiana -28 ethyl acetate mycelial extracts produced mosquitocidal activity against larvae and pupae which was comparable to that of the commercial insecticide B. bassiana -22 extract. The LC50 (lethal concentration that kills 50% of the exposed larvae) values of B...
March 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29507109/epitope-binding-characteristics-for-risk-versus-protective-drb1-alleles-for-visceral-leishmaniasis
#15
Toolika Singh, Michaela Fakiola, Joyce Oommen, Akhil Pratap Singh, Abhishek K Singh, Noel Smith, Jaya Chakravarty, Shyam Sundar, Jenefer M Blackwell
HLA-DRB1 is the major genetic risk factor for visceral leishmaniasis (VL). We used SNP2HLA to impute HLA-DRB1 alleles and SNPTEST to carry out association analyses in 889 human cases and 977 controls from India. NetMHCIIpan 2.1 was used to map epitopes and binding affinities across 49 Leishmania vaccine candidates, as well as across peptide epitopes captured from dendritic cells treated with crude Leishmania Ag and identified using mass spectrometry and alignment to amino acid sequences of a reference Leishmania genome...
April 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29447812/total-serum-bilirubin-levels-and-sensorineural-hearing-loss-in-the-us-adolescents-nhanes-2007-2010
#16
Guoli Zhou, Wenjiang Fu
OBJECTIVE: We aimed to investigate whether current levels of total serum bilirubin are associated with different subtypes of sensorineural hearing loss (SNHL) in adolescents. METHODS: A set of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) (2007-2010) was used. A subset of 1404 adolescents was sampled for measurements of total serum bilirubin, tympanometry, and average pure tone threshold at low-frequencies (LPTA: 500, 1000, 2000 Hz) or high-frequencies (HPTA: 3000, 4000, 6000, and 8000 Hz)...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29405058/suspect-screening-analysis-of-chemicals-in-consumer-products
#17
Katherine A Phillips, Alice Yau, Kristin A Favela, Kristin K Isaacs, Andrew McEachran, Christopher Grulke, Ann M Richard, Antony J Williams, Jon R Sobus, Russell S Thomas, John F Wambaugh
A two-dimensional gas chromatography-time-of-flight/mass spectrometry (GC×GC-TOF/MS) suspect screening analysis method was used to rapidly characterize chemicals in 100 consumer products-which included formulations (e.g., shampoos, paints), articles (e.g., upholsteries, shower curtains), and foods (cereals)-and therefore supports broader efforts to prioritize chemicals based on potential human health risks. Analyses yielded 4270 unique chemical signatures across the products, with 1602 signatures tentatively identified using the National Institute of Standards and Technology 2008 spectral database...
March 6, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29401151/spect-ct-with-the-psma-ligand-99mtc-mip-1404-for-whole-body-primary-staging-of-patients-with-prostate-cancer
#18
Christian Schmidkonz, Michael Cordes, Michael Beck, Theresa Ida Goetz, Daniela Schmidt, Olaf Prante, Tobias Bäuerle, Michael Uder, Bernd Wullich, Peter Goebell, Torsten Kuwert, Philipp Ritt
BACKGROUND: Tc-MIP-1404 (Progenics Pharmaceuticals, Inc, New York, NY) is a novel ligand binding to prostate-specific membrane antigen suitable for SPECT. There are, as yet, no data concerning its use in whole-body primary staging and its interobserver variability in patients with prostate cancer (PC) prior to therapy. METHODS: A search of our clinical database from April 2013 to May 2017 yielded 93 patients with histologically confirmed cancer in whom Tc-MIP-1404 SPECT/CT had been performed for primary whole-body staging before therapy...
April 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29363255/health-related-life-satisfaction-and-its-influencing-factors-a-cross-sectional-study-in-china
#19
Shou-Qi Wang, Jie Ying, Mei-Ling Zhang, Ying Shi, Yuan Li, Zhuang-Jie Xing, Huan-Huan Li, Jiao Sun
AIM: With the rapid development of science and technology, the pace of life has accelerated. Health and life satisfaction issues of persons are gaining more attention. China, Japan, Malaysia, and Taiwan conducted international cooperative research on health of four regional populations. This research was a part of the study in mainland China, which aimed to explore health-related life satisfaction and its influencing factors on large samples in mainland China. METHODS: A random group of 1404 persons from universities, factories, companies, and elderly centers in Changchun completed a structured questionnaire...
January 24, 2018: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/29298160/myeloablative-autologous-stem-cell-transplantation-for-severe-scleroderma
#20
RANDOMIZED CONTROLLED TRIAL
Keith M Sullivan, Ellen A Goldmuntz, Lynette Keyes-Elstein, Peter A McSweeney, Ashley Pinckney, Beverly Welch, Maureen D Mayes, Richard A Nash, Leslie J Crofford, Barry Eggleston, Sharon Castina, Linda M Griffith, Julia S Goldstein, Dennis Wallace, Oana Craciunescu, Dinesh Khanna, Rodney J Folz, Jonathan Goldin, E William St Clair, James R Seibold, Kristine Phillips, Shin Mineishi, Robert W Simms, Karen Ballen, Mark H Wener, George E Georges, Shelly Heimfeld, Chitra Hosing, Stephen Forman, Suzanne Kafaja, Richard M Silver, Leroy Griffing, Jan Storek, Sharon LeClercq, Richard Brasington, Mary E Csuka, Christopher Bredeson, Carolyn Keever-Taylor, Robyn T Domsic, M Bashar Kahaleh, Thomas Medsger, Daniel E Furst
BACKGROUND: Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma) often has a devastating outcome. We compared myeloablative CD34+ selected autologous hematopoietic stem-cell transplantation with immunosuppression by means of 12 monthly infusions of cyclophosphamide in patients with scleroderma. METHODS: We randomly assigned adults (18 to 69 years of age) with severe scleroderma to undergo myeloablative autologous stem-cell transplantation (36 participants) or to receive cyclophosphamide (39 participants)...
January 4, 2018: New England Journal of Medicine
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