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https://www.readbyqxmd.com/read/28327445/nine-differentially-expressed-genes-from-a-post-mortem-study-and-their-association-with-suicidal-status-in-a-sample-of-suicide-completers-attempters-and-controls
#1
Martina Balestri, Concetta Crisafulli, Luigi Donato, Ina Giegling, Raffaella Calati, Niki Antypa, Barbara Schneider, Dragan Marusic, Maria Eugenia Tarozzi, Dorjan Marusic, Metka Paragi, Annette M Hartmann, Bettina Konte, Agnese Marsano, Alessandro Serretti, Dan Rujescu
Several lines of evidence indicate that suicidal behaviour is partly heritable, with multiple genes implicated in its aetiology. We focused on nine genes (S100A13, EFEMP1, PCDHB5, PDGFRB, CDCA7L, SCN2B, PTPRR, MLC1 and ZFP36) which we previously detected as differentially expressed in the cortex of suicide victims compared to controls. We investigated 84 variants within these genes in 495 suicidal subjects (299 completers and 196 attempters) and 1513 controls (109 post-mortem and 1404 healthy). We evaluated associations with: 1) suicidal phenotype; 2) possible endophenotypes for suicidal behaviour...
March 10, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28302763/phase-2-study-of-99m-tc-trofolastat-spect-ct-to-identify-and-localize-prostate-cancer-in-intermediate-and-high-risk-patients-undergoing-radical-prostatectomy-and-extended-pelvic-lymph-node-dissection
#2
Karolien E Goffin, Steven Joniau, Peter Tenke, Kevin Slawin, Eric A Klein, Nancy Stambler, Thomas Strack, John Babich, Thomas Armor, Vivien Wong
Rationale:(99m)Tc-trofolastat ((99m)Tc-MIP-1404), a small-molecule inhibitor of prostate-specific membrane antigen (PSMA), shows high potential to detect prostate cancer (PCa) non-invasively using single-photon-emission-computed-tomography (SPECT). We therefore wanted to assess the performance of (99m)Tc-trofolastat SPECT/CT in a phase 2 multi-center, multi-reader prospective study in patients with intermediate- and high-grade PCa, prior to radical prostatectomy and extended pelvic lymph node dissection, with histopathology as gold standard...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28270338/satisfaction-with-sex-life-among-patients-with-schizophrenia
#3
Neelam Laxhman, Lauren Greenberg, Stefan Priebe
BACKGROUND: Whilst subjective quality of life has been extensively studied in patients with schizophrenia, little is known specifically about their satisfaction with their sex lives. Aim To assess the level of satisfaction with sex lives of patients with schizophrenia and explore patient characteristics associated with lower satisfaction. METHOD: Data of five independent samples of patients with schizophrenia or related disorders (ICD-10 F20-29) were analysed. Quality of life including satisfaction with sex life was assessed on the Manchester Short Assessment of Quality of Life...
March 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28228505/postdiagnostic-mediterranean-and-healthy-nordic-dietary-patterns-are-inversely-associated-with-all-cause-mortality-in-long-term-colorectal-cancer-survivors
#4
Ilka Ratjen, Clemens Schafmayer, Romina di Giuseppe, Sabina Waniek, Sandra Plachta-Danielzik, Manja Koch, Ute Nöthlings, Jochen Hampe, Sabrina Schlesinger, Wolfgang Lieb
Background: Dietary factors are known to affect the risk of new-onset colorectal cancer (CRC), but information on the extent to which postdiagnostic diet affects mortality in long-term CRC survivors is scarce.Objective: We investigated the association of 2 a priori-defined postdiagnostic dietary patterns [Modified Mediterranean Diet Score (MMDS) and healthy Nordic Food Index (HNFI)] with all-cause mortality in long-term CRC survivors.Methods: Diet was assessed at a median time of 6 y after cancer diagnosis in 1404 CRC survivors (median age: 69 y; 56% men) in a prospective cohort study in Northern Germany by using a semiquantitative food-frequency questionnaire...
February 22, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28095557/the-photodynamic-therapy-experience-of-a-high-volume-laser-and-dermatologic-surgery-center
#5
David E Orbuch, Lauren Penn, Bradley S Bloom, Jeremy A Brauer, Daniel B Shin, Joshua Greenbaum, Leonard J Bernstein, Elliot T Weiss, Robert T Anolik, Roy G Geronemus
BACKGROUND: Photodynamic therapy (PDT) is an FDA approved treatment for actinic keratoses (AK's) although multiple off-label indi- cations are reported. Despite frequent use for AK's, no clear consensus exists regarding protocols for overall treatment parameters. METHODS: Retrospective chart review of 1,491 subjects who underwent PDT between 2007 and 2011 at a high volume laser surgery center. Demographic information, clinical history, treatment data, and subsequent diagnosis of skin cancers were recorded...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28088341/evaluation-of-an-in-house-indirect-elisa-for-detection-of-antibody-against-haemorrhagic-septicemia-in-asian-elephants
#6
Pallop Tankaew, Thawatchai Singh-La, Chatchote Titaram, Veerasak Punyapornwittaya, Preeyanat Vongchan, Takuo Sawada, Nattawooti Sthitmatee
Pasteurella multocida causes haemorrhagic septicemia in livestock and wild animals, including elephants. The disease has been reported in Asian elephants in India and Sri Lanka, but to date there have been no reported cases in Thailand. ELISA or indirect hemagglutination assays (IHA) have been demonstrated to be able to detect the antibody against the disease in cattle, but no data are available for elephants. The present study reports a novel in-house indirect ELISA for antibody detection of haemorrhagic septicemia in Asian elephants, and evaluates the sensitivity and specificity of the method using a Bayesian approach...
January 12, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28052186/axillary-treatment-for-operable-primary-breast-cancer
#7
REVIEW
Nathan Bromham, Mia Schmidt-Hansen, Margaret Astin, Elise Hasler, Malcolm W Reed
BACKGROUND: Axillary surgery is an established part of the management of primary breast cancer. It provides staging information to guide adjuvant therapy and potentially local control of axillary disease. Several alternative approaches to axillary surgery are available, most of which aim to spare a proportion of women the morbidity of complete axillary dissection. OBJECTIVES: To assess the benefits and harms of alternative approaches to axillary surgery (including omitting such surgery altogether) in terms of overall survival; local, regional and distant recurrences; and adverse events...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28031538/variants-in-microrna-genes-in-familial-papillary-thyroid-carcinoma
#8
Jerneja Tomsic, Rebecca Fultz, Sandya Liyanarachchi, Luke K Genutis, Yanqiang Wang, Wei Li, Stefano Volinia, Krystian Jazdzewski, Huiling He, Paul E Wakely, Leigha Senter, Albert de la Chapelle
Papillary Thyroid Carcinoma (PTC) displays one of the highest familiality scores of all cancers as measured by case-control studies, yet only a handful of genes have been implicated until now. Variants in microRNAs have been associated with the risk of several cancers including PTC but the magnitude of this involvement is unclear. This study was designed to test to what extent genomic variants in microRNAs contribute to PTC risk. We used SOLiD technology to sequence 321 genomic regions encoding 427 miRNAs in one affected individual from each of 80 PTC families...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28005558/residual-thromboxane-activity-and-oxidative-stress-influence-on-mortality-in-patients-with-stable-coronary-artery-disease
#9
Anupama Vasudevan, Teodoro Bottiglieri, Kristen M Tecson, Mohanakrishnan Sathyamoorthy, Jeffrey M Schussler, Carlos E Velasco, Luis R Lopez, Caren Swift, Margarita Peterson, Jeanna Bennett-Firmin, Raphael Schiffmann, Peter A McCullough
BACKGROUND: Aspirin use is effective in the prevention of cardiovascular disease; however, not all patients are equally responsive to aspirin. Oxidative stress reflected by F2-isoprostane [8-iso-prostaglandin-F2α (8-IsoPGF2α)] is a potential mechanism of failure of aspirin to adequately inhibit cyclooxygenase-1. The objective was to examine the relation between all-cause mortality and the concentrations of urinary 11-dehydro thromboxane B2 (11dhTxB2) and 8-IsoPGF2α in patients with stable coronary artery disease (CAD)...
December 21, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/28000444/diagnosis-and-classification-of-17-diseases-from-1404-subjects-via-pattern-analysis-of-exhaled-molecules
#10
Morad K Nakhleh, Haitham Amal, Raneen Jeries, Yoav Y Broza, Manal Aboud, Alaa Gharra, Hodaya Ivgi, Salam Khatib, Shifaa Badarneh, Lior Har-Shai, Lea Glass-Marmor, Izabella Lejbkowicz, Ariel Miller, Samih Badarny, Raz Winer, John Finberg, Sylvia Cohen-Kaminsky, Frédéric Perros, David Montani, Barbara Girerd, Gilles Garcia, Gérald Simonneau, Farid Nakhoul, Shira Baram, Raed Salim, Marwan Hakim, Maayan Gruber, Ohad Ronen, Tal Marshak, Ilana Doweck, Ofer Nativ, Zaher Bahouth, Da-You Shi, Wei Zhang, Qing-Ling Hua, Yue-Yin Pan, Li Tao, Hu Liu, Amir Karban, Eduard Koifman, Tova Rainis, Roberts Skapars, Armands Sivins, Guntis Ancans, Inta Liepniece-Karele, Ilze Kikuste, Ieva Lasina, Ivars Tolmanis, Douglas Johnson, Stuart Z Millstone, Jennifer Fulton, John W Wells, Larry H Wilf, Marc Humbert, Marcis Leja, Nir Peled, Hossam Haick
We report on an artificially intelligent nanoarray based on molecularly modified gold nanoparticles and a random network of single-walled carbon nanotubes for noninvasive diagnosis and classification of a number of diseases from exhaled breath. The performance of this artificially intelligent nanoarray was clinically assessed on breath samples collected from 1404 subjects having one of 17 different disease conditions included in the study or having no evidence of any disease (healthy controls). Blind experiments showed that 86% accuracy could be achieved with the artificially intelligent nanoarray, allowing both detection and discrimination between the different disease conditions examined...
January 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/27982068/the-management-and-prognostic-prediction-of-adenocarcinoma-of-appendix
#11
Xin Xie, Zhangjian Zhou, Yongchun Song, Wenhan Li, Dongmei Diao, Chengxue Dang, Hao Zhang
Malignant tumours of the appendix are quite rare, especially appendiceal adenocarcinomas, which may be difficult to detect preoperatively or intraoperatively. We collected data for 1404 patients with adenocarcinoma of the appendix from the Surveillance, Epidemiology, and End Results Program (SEER) database to explore the potential associations between clinicopathological factors and overall survival. Furthermore, a novel nomogram for predicting prognosis was developed based on our analysis of the SEER data...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27941764/gvhd-after-umbilical-cord-blood-transplantation-for-acute-leukemia-an-analysis-of-risk-factors-and-effect-on-outcomes
#12
Y-B Chen, T Wang, M T Hemmer, C Brady, D R Couriel, A Alousi, J Pidala, A Urbano-Ispizua, S W Choi, T Nishihori, T Teshima, Y Inamoto, B Wirk, D I Marks, H Abdel-Azim, L Lehmann, L Yu, M Bitan, M S Cairo, M Qayed, R Salit, R P Gale, R Martino, S Jaglowski, A Bajel, B Savani, H Frangoul, I D Lewis, J Storek, M Askar, M A Kharfan-Dabaja, M Aljurf, O Ringden, R Reshef, R F Olsson, S Hashmi, S Seo, T R Spitzer, M L MacMillan, A Lazaryan, S R Spellman, M Arora, C S Cutler
Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, we analyzed 1404 umbilical cord blood transplantation (UCBT) patients (single (<18 years)=810, double (⩾18 years)=594) with acute leukemia to define the incidence of acute GvHD (aGvHD) and chronic GvHD (cGvHD), analyze clinical risk factors and investigate outcomes. After single UCBT, 100-day incidence of grade II-IV aGvHD was 39% (95% confidence interval (CI), 36-43%), grade III-IV aGvHD was 18% (95% CI, 15-20%) and 1-year cGvHD was 27% (95% CI, 24-30%)...
March 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27939121/the-anastomoses-of-the-recurrent-laryngeal-nerve-in-the-larynx-a-meta-analysis-and-systematic-review
#13
REVIEW
Brandon Michael Henry, Przemysław A Pękala, Beatrice Sanna, Jens Vikse, Silvia Sanna, Karolina Saganiak, Iwona M Tomaszewska, R Shane Tubbs, Krzysztof A Tomaszewski
OBJECTIVES: The recurrent laryngeal nerve and its branches form a great variety of anastomoses. These nerve communications can alter the innervation patterns of the laryngeal muscles and can affect both the diagnosis and treatment of paralyzed vocal cords. The aim of this study was to assess the prevalence and anatomical characteristics of the laryngeal nerve connections, and to review their function and clinical significance. STUDY DESIGN: Meta-analysis and systematic review...
December 6, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27931045/breast-cancer-in-neurofibromatosis-type-1-overrepresentation-of-unfavourable-prognostic-factors
#14
Elina Uusitalo, Roope A Kallionpää, Samu Kurki, Matti Rantanen, Janne Pitkäniemi, Pauliina Kronqvist, Pirkko Härkönen, Riikka Huovinen, Olli Carpen, Minna Pöyhönen, Sirkku Peltonen, Juha Peltonen
BACKGROUND: An increased breast cancer incidence and poor survival have been reported for women with neurofibromatosis 1 (NF1). To explain the poor survival, we aimed to link the histopathology and clinical characteristics of NF1-associated breast cancers. METHODS: The Finnish Cancer Registry and the Finnish NF Registry were cross-referenced to identify the NF1 patients with breast cancer. Archival NF1 breast cancer specimens were retrieved for histopathological typing and compared with matched controls...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27930440/association-of-night-time-home-blood-pressure-with-night-time-ambulatory-blood-pressure-and-target-organ-damage-a-systematic-review-and-meta-analysis
#15
Anastasios Kollias, Angeliki Ntineri, George S Stergiou
OBJECTIVE: Night-time ambulatory blood pressure (nABP) is the most important aspect of the blood pressure profile in terms of prognosis. Novel low-cost home monitors allow automated night-time blood pressure monitoring (nHBP). This study reviewed the evidence on the association of nHBP with nABP and preclinical organ damage. METHODS: Systematic review and meta-analysis. RESULTS: Analysis of six studies (n = 1404) showed pooled difference between nHBP and nABP (SBP/DBP) at 1...
March 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27851040/1404-incidence-timing-and-outcomes-of-icu-transfer-in-patients-admitted-for-infection
#16
Alan Heffner, Colleen Karvetski
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27792642/cardiac-vulnerability-to-cerebrogenic-stress-as-a-possible-cause-of-troponin-elevation-in-stroke
#17
Sung-Ho Ahn, Young-Hak Kim, Chol-Ho Shin, Ji-Sung Lee, Bum-Joon Kim, Yeon-Jung Kim, Sang-Mi Noh, Seung-Min Kim, Hyun-Goo Kang, Dong-Wha Kang, Jong S Kim, Sun U Kwon
BACKGROUND: Troponin elevation with electrocardiography changes is not uncommon in patients with acute ischemic stroke; however, it is still unclear whether the mechanism of these changes is due to cardiac problems or neurally mediated myocytic damage. Thus, we investigated cardiac and neurological predictors of troponin elevation in those patients. METHODS AND RESULTS: We retrospectively analyzed medical data of the prospectively registered ischemic stroke patients on stroke registry who were admitted and underwent a serum cardiac troponin I and 12-lead electrocardiography within 24 hours of symptom onset...
October 6, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27786143/age-related-variability-in-the-presentation-of-symptoms-of-major-depressive-disorder
#18
R Schaakxs, H C Comijs, F Lamers, A T F Beekman, B W J H Penninx
BACKGROUND: The heterogeneous aetiology of major depressive disorder (MDD) might affect the presentation of depressive symptoms across the lifespan. We examined to what extent a range of mood, cognitive, and somatic/vegetative depressive symptoms were differentially present depending on patient's age. METHOD: Data came from 1404 participants with current MDD (aged 18-88 years) from two cohort studies: the Netherlands Study of Depression and Anxiety (NESDA) and the Netherlands Study of Depression in Older Persons (NESDO)...
October 27, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27785901/annual-report-of-the-women-s-health-care-committee-japan-society-of-obstetrics-and-gynecology-2016
#19
Kiyoshi Takamatsu, Jo Kitawaki
In order to improve women's quality of life, over the year leading up to June 2016, the Women's Health Care Committee of the Japan Society of Obstetrics and Gynecology focused upon: (i) breast management; (ii) influence of a therapy for gynecologic disease on physical condition; (iii) nonsurgical management of pelvic organ prolapse; (iv) survey of infectious diseases in Obstetrics and Gynecology in Japan; (v) health care for female athletes; (vi) a training program for women's health-care advisers; and (vii) revising the Japanese guideline on hormone-replacement therapy...
November 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27775936/first-experience-with-spect-ct-using-a-99mtc-labeled-inhibitor-for-prostate-specific-membrane-antigen-in-patients-with-biochemical-recurrence-of-prostate-cancer
#20
Julia Reinfelder, Torsten Kuwert, Michael Beck, James C Sanders, Philipp Ritt, Christian Schmidkonz, Peter Hennig, Olaf Prante, Michael Uder, Bernd Wullich, Peter Goebell
AIM: Prostate-specific membrane antigen (PSMA) is overexpressed in most prostate cancers (PCs). Here, we report our first experience using the Tc-labeled PSMA inhibitor MIP-1404 (Progenics Pharmaceuticals, Inc, Tarrytown, NY) in 60 patients with biochemically recurrent PC. METHODS: Whole-body planar scintigraphy and SPECT/CT of the lower abdominal pelvic region of 60 patients with biochemical relapse of PC were analyzed retrospectively. In these subjects, an average dose of 733...
January 2017: Clinical Nuclear Medicine
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