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https://www.readbyqxmd.com/read/29594154/a-systems-approach-to-evaluate-one-health-initiatives
#1
Simon R Rüegg, Liza Rosenbaum Nielsen, Sandra C Buttigieg, Mijalche Santa, Maurizio Aragrande, Massimo Canali, Timothy Ehlinger, Ilias Chantziaras, Elena Boriani, Miroslav Radeski, Mieghan Bruce, Kevin Queenan, Barbara Häsler
Challenges calling for integrated approaches to health, such as the One Health (OH) approach, typically arise from the intertwined spheres of humans, animals, and ecosystems constituting their environment. Initiatives addressing such wicked problems commonly consist of complex structures and dynamics. As a result of the EU COST Action (TD 1404) "Network for Evaluation of One Health" (NEOH), we propose an evaluation framework anchored in systems theory to address the intrinsic complexity of OH initiatives and regard them as subsystems of the context within which they operate...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29555910/analysis-of-microrna-and-gene-expression-profiles-in-alzheimer-s-disease-a-meta-analysis-approach
#2
Shirin Moradifard, Moslem Hoseinbeyki, Shahla Mohammad Ganji, Zarrin Minuchehr
Understanding the molecular mechanisms underlying Alzheimer's disease (AD) is necessary for the diagnosis and treatment of this neurodegenerative disorder. It is therefore important to detect the most important genes and miRNAs, which are associated with molecular events, and studying their interactions for recognition of AD mechanisms. Here we focus on the genes and miRNAs expression profile, which we have detected the miRNA target genes involved in AD. These are the most quintessential to find the most important miRNA, to target genes and their important pathways...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29546639/beetroot-supplementation-improves-the-physiological-responses-to-incline-walking
#3
Mark Waldron, Luke Waldron, Craig Lawlor, Adrian Gray, Jamie Highton
PURPOSE: We investigated the effects of an acute 24-h nitrate-rich beetroot juice supplement (BR) on the energy cost, exercise efficiency and blood pressure responses to intermittent walking at different gradients. METHODS: In a double-blind, cross-over design, eight participants were provided with a total of 350 ml of nitrate-rich (~ 20.5 mmol nitrate) BR or placebo (PLA) across 24 h before completing intermittent walking at 3 km/h on treadmill at gradients of 1, 5, 10, 15 and 20%...
March 15, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29518269/viral-etiologies-of-influenza-like-illness-and-severe-acute-respiratory-infections-in-thailand
#4
Malinee Chittaganpitch, Sunthareeya Waicharoen, Thitipong Yingyong, Prabda Praphasiri, Somchai Sangkitporn, Sonja J Olsen, Kim A Lindblade
BACKGROUND: Information on the burden, characteristics and seasonality of non-influenza respiratory viruses is limited in tropical countries. OBJECTIVES: Describe the epidemiology of selected non-influenza respiratory viruses in Thailand between June 2010 and May 2014 using a sentinel surveillance platform established for influenza. METHODS: Patients with influenza-like illness (ILI; history of fever or documented temperature >38°C, cough, not requiring hospitalization) or severe acute respiratory infection (SARI; history of fever or documented temperature >38°C, cough, onset <10 days, requiring hospitalization) were enrolled from 10 sites...
March 8, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29513054/influence-of-inter-observer-delineation-variability-on-radiomics-stability-in-different-tumor-sites
#5
Matea Pavic, Marta Bogowicz, Xaver Würms, Stefan Glatz, Tobias Finazzi, Oliver Riesterer, Johannes Roesch, Leonie Rudofsky, Martina Friess, Patrick Veit-Haibach, Martin Huellner, Isabelle Opitz, Walter Weder, Thomas Frauenfelder, Matthias Guckenberger, Stephanie Tanadini-Lang
BACKGROUND: Radiomics is a promising methodology for quantitative analysis and description of radiological images using advanced mathematics and statistics. Tumor delineation, which is still often done manually, is an essential step in radiomics, however, inter-observer variability is a well-known uncertainty in radiation oncology. This study investigated the impact of inter-observer variability (IOV) in manual tumor delineation on the reliability of radiomic features (RF). METHODS: Three different tumor types (head and neck squamous cell carcinoma (HNSCC), malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC)) were included...
March 7, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29510502/toxicity-of-beauveria-bassiana-28-mycelial-extracts-on-larvae-of-culex-quinquefasciatus-mosquito-diptera-culicidae
#6
Perumal Vivekanandhan, Thangaraj Kavitha, Sengodan Karthi, Sengottayan Senthil-Nathan, Muthugoundar Subramanian Shivakumar
Microbial-based pest control is an attractive alternative to chemical insecticides. The present study sought to evaluate the toxicity of the entomopathogenic fungus Beauveria bassiana -28 ethyl acetate extracts on different larval stages and pupae of Culex quinquefasciatus mosquitoes. B. bassiana -28 ethyl acetate mycelial extracts produced mosquitocidal activity against larvae and pupae which was comparable to that of the commercial insecticide B. bassiana -22 extract. The LC50 (lethal concentration that kills 50% of the exposed larvae) values of B...
March 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29507109/epitope-binding-characteristics-for-risk-versus-protective-drb1-alleles-for-visceral-leishmaniasis
#7
Toolika Singh, Michaela Fakiola, Joyce Oommen, Akhil Pratap Singh, Abhishek K Singh, Noel Smith, Jaya Chakravarty, Shyam Sundar, Jenefer M Blackwell
HLA-DRB1 is the major genetic risk factor for visceral leishmaniasis (VL). We used SNP2HLA to impute HLA-DRB1 alleles and SNPTEST to carry out association analyses in 889 human cases and 977 controls from India. NetMHCIIpan 2.1 was used to map epitopes and binding affinities across 49 Leishmania vaccine candidates, as well as across peptide epitopes captured from dendritic cells treated with crude Leishmania Ag and identified using mass spectrometry and alignment to amino acid sequences of a reference Leishmania genome...
March 5, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29447812/total-serum-bilirubin-levels-and-sensorineural-hearing-loss-in-the-us-adolescents-nhanes-2007-2010
#8
Guoli Zhou, Wenjiang Fu
OBJECTIVE: We aimed to investigate whether current levels of total serum bilirubin are associated with different subtypes of sensorineural hearing loss (SNHL) in adolescents. METHODS: A set of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) (2007-2010) was used. A subset of 1404 adolescents was sampled for measurements of total serum bilirubin, tympanometry, and average pure tone threshold at low-frequencies (LPTA: 500, 1000, 2000 Hz) or high-frequencies (HPTA: 3000, 4000, 6000, and 8000 Hz)...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29405058/suspect-screening-analysis-of-chemicals-in-consumer-products
#9
Katherine Phillips, Alice Y Yau, Kristin Ann Favela, Kristin K Isaacs, Andrew McEachran, Christopher M Grulke, Ann M Richard, Antony Williams, Jon Russell Sobus, Russell S Thomas, John F Wambaugh
A two-dimensional gas chromatography-time of flight/mass spectrometry (GC×GC-TOF/MS) suspect screening analysis method was used to rapidly characterize chemicals in 100 consumer products - which included formulations (e.g., shampoos, paints), articles (e.g., upholsteries, shower curtains), and foods (cereals) - and therefore supports broader efforts to prioritize chemicals based on potential human health risks. Analyses yielded 4270 unique chemical signatures across the products, with 1602 signatures tentatively identified using the National Institute of Standards and Technology 2008 spectral database...
February 6, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29401151/spect-ct-with-the-psma-ligand-99mtc-mip-1404-for-whole-body-primary-staging-of-patients-with-prostate-cancer
#10
Christian Schmidkonz, Michael Cordes, Michael Beck, Theresa Ida Goetz, Daniela Schmidt, Olaf Prante, Tobias Bäuerle, Michael Uder, Bernd Wullich, Peter Goebell, Torsten Kuwert, Philipp Ritt
BACKGROUND: Tc-MIP-1404 (Progenics Pharmaceuticals, Inc, New York, NY) is a novel ligand binding to prostate-specific membrane antigen suitable for SPECT. There are, as yet, no data concerning its use in whole-body primary staging and its interobserver variability in patients with prostate cancer (PC) prior to therapy. METHODS: A search of our clinical database from April 2013 to May 2017 yielded 93 patients with histologically confirmed cancer in whom Tc-MIP-1404 SPECT/CT had been performed for primary whole-body staging before therapy...
April 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29363255/health-related-life-satisfaction-and-its-influencing-factors-a-cross-sectional-study-in-china
#11
Shou-Qi Wang, Jie Ying, Mei-Ling Zhang, Ying Shi, Yuan Li, Zhuang-Jie Xing, Huan-Huan Li, Jiao Sun
AIM: With the rapid development of science and technology, the pace of life has accelerated. Health and life satisfaction issues of persons are gaining more attention. China, Japan, Malaysia, and Taiwan conducted international cooperative research on health of four regional populations. This research was a part of the study in mainland China, which aimed to explore health-related life satisfaction and its influencing factors on large samples in mainland China. METHODS: A random group of 1404 persons from universities, factories, companies, and elderly centers in Changchun completed a structured questionnaire...
January 24, 2018: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/29298160/myeloablative-autologous-stem-cell-transplantation-for-severe-scleroderma
#12
RANDOMIZED CONTROLLED TRIAL
Keith M Sullivan, Ellen A Goldmuntz, Lynette Keyes-Elstein, Peter A McSweeney, Ashley Pinckney, Beverly Welch, Maureen D Mayes, Richard A Nash, Leslie J Crofford, Barry Eggleston, Sharon Castina, Linda M Griffith, Julia S Goldstein, Dennis Wallace, Oana Craciunescu, Dinesh Khanna, Rodney J Folz, Jonathan Goldin, E William St Clair, James R Seibold, Kristine Phillips, Shin Mineishi, Robert W Simms, Karen Ballen, Mark H Wener, George E Georges, Shelly Heimfeld, Chitra Hosing, Stephen Forman, Suzanne Kafaja, Richard M Silver, Leroy Griffing, Jan Storek, Sharon LeClercq, Richard Brasington, Mary E Csuka, Christopher Bredeson, Carolyn Keever-Taylor, Robyn T Domsic, M Bashar Kahaleh, Thomas Medsger, Daniel E Furst
BACKGROUND: Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma) often has a devastating outcome. We compared myeloablative CD34+ selected autologous hematopoietic stem-cell transplantation with immunosuppression by means of 12 monthly infusions of cyclophosphamide in patients with scleroderma. METHODS: We randomly assigned adults (18 to 69 years of age) with severe scleroderma to undergo myeloablative autologous stem-cell transplantation (36 participants) or to receive cyclophosphamide (39 participants)...
January 4, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29290249/a-phase-i-trial-of-afatinib-and-bevacizumab-in-chemo-na%C3%A3-ve-patients-with-advanced-non-small-cell-lung-cancer-harboring-egfr-mutations-okayama-lung-cancer-study-group-trial-1404
#13
Takashi Ninomiya, Naoyuki Nogami, Toshiyuki Kozuki, Daijiro Harada, Toshio Kubo, Kadoaki Ohashi, Shoichi Kuyama, Kenichiro Kudo, Akihiro Bessho, Nobuaki Fukamatsu, Nobukazu Fujimoto, Keisuke Aoe, Takuo Shibayama, Keisuke Sugimoto, Nagio Takigawa, Katsuyuki Hotta, Katsuyuki Kiura
OBJECTIVE: In advanced epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC), treatment with afatinib, a second-generation EGFR-tyrosine kinase inhibitor (TKI), confers a significant survival benefit over platinum-based chemotherapy. The first-generation EGFR-TKIs gefitinib and erlotinib in combination with bevacizumab have improved progression-free survival. We hypothesized that the combination of afatinib with bevacizumab would further improve efficacy, and conducted a phase I trial to test this hypothesis...
January 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29260894/the-use-of-the-patient-reported-outcomes-measurement-information-system-and-the-rand-vsq9-to-measure-the-quality-of-life-and-visit-specific-satisfaction-of-pregnant-patients-under-chiropractic-care-utilizing-the-webster-technique
#14
Joel Alcantara, Andrea Lamont Nazarenko, Jeanne Ohm, Junjoe Alcantara
OBJECTIVE: To quantify the quality of life (QoL) and visit-specific satisfaction of pregnant women. DESIGN: A prospective cohort within a practice-based research network (PBRN). Setting/Locations: Individual chiropractic offices. SUBJECTS: Pregnant women (age ≥18 years) attending chiropractic care. INTERVENTION(S): Chiropractic care (i.e., The Webster Technique, spinal adjustments, and adjunctive therapies). MAIN OUTCOME MEASURES: The RAND VSQ9 to measure visit-specific satisfaction and the Patient Reported Outcomes Measurement Information System (PROMIS® )-29 to measure QoL...
January 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29246780/comparison-of-two-indirect-elisa-coating-antigens-for-the-detection-of-dairy-cow-antibodies-against-pasteurella-multocida
#15
Pallop Tankaew, Wanwisa Srisawat, Tawatchai Singhla, Khajornsak Tragoolpua, Yasushi Kataoka, Takuo Sawada, Nattawooti Sthitmatee
The ELISA is recognized as an efficient diagnostic tool for antibody detection, but there is no standard ELISA assay for detection of antibodies against hemorrhagic septicemia (HS) in cattle. The present study reports on an indirect ELISA assay for antibody detection of HS in dairy cows, and evaluates the sensitivity (Se) and specificity (Sp) of the method using a Bayesian approach. An indirect ELISA was developed with two types of heat extract antigens, Pasteurella multocida strains P-1256 and M-1404, as coating antigens...
February 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29208775/cns-endothelial-cell-activation-emerges-as-a-driver-of-car-t-cell-associated-neurotoxicity
#16
COMMENT
Crystal L Mackall, David B Miklos
<b/> Central nervous system (CNS) toxicity associated with chimeric antigen receptor-based therapeutics has emerged as a significant cause of morbidity and mortality, and insights into the pathophysiology of this syndrome have been lacking. A new study provides evidence that cytokine-induced CNS endothelial cell activation leading to disruption of the blood-brain barrier plays an early and critical role in this phenomenon. These insights provide new opportunities for targeted therapeutic interventions to modulate endothelial cell activation...
December 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29208319/defining-the-incidence-and-clinical-significance-of-lymph-node-metastasis-in-soft-tissue-sarcoma
#17
Emily Z Keung, Yi-Ju Chiang, Rachel K Voss, Janice N Cormier, Keila E Torres, Kelly K Hunt, Barry W Feig, Christina L Roland
INTRODUCTION: The incidence and clinical significance of lymph node metastasis (LNM, N1) in soft tissue sarcoma (STS) is unclear. Recent studies have focused on extremity/trunk STS (ETSTS). We sought to define the subgroup of patients with LNM at sarcoma diagnosis across all disease sites and histologies. METHODS: We identified and categorized 89,870 STS patients from the National Cancer Data Base (1998-2012) by nodal stage. Pathologically confirmed LNM (pN1) were identified in 1404 patients; 1750 had clinically suspicious but not pathologically confirmed LNM (cN1)...
January 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29109353/intranasal-immunization-with-a-recombinant-outer-membrane-protein-h-based-haemorrhagic-septicemia-vaccine-in-dairy-calves
#18
Korkiat Muangthai, Pallop Tankaew, Thanya Varinrak, Ratchanee Uthi, Suvichai Rojanasthien, Takuo Sawada, Nattawooti Sthitmatee
Haemorrhagic septicemia (HS) is a contagious disease in cattle with high morbidity and mortality rates. HS vaccine in Thailand is an oil-adjuvant formulation, and is difficult to administer. The present study aimed to formulate and evaluate the protection in dairy calves conferred by immunization with an in-house intranasal HS vaccine. The intranasal vaccine was formulated in a total volume of 500 µl containing either 50 or 100 µg of the recombinant outer membrane protein H (rOmpH) of Pasteurella multocida strain M-1404 (serovar B:2), and 10 µg of Cytosine-phosphate-guanosine oligodeoxynucleotides (CpG-ODN) as a mucosal adjuvant...
November 6, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29105797/-99m-tc-mip-1404-spect-ct-for-the-detection-of-psma-positive-lesions-in-225-patients-with-biochemical-recurrence-of-prostate-cancer
#19
Christian Schmidkonz, Claudia Hollweg, Michael Beck, Julia Reinfelder, Theresa I Goetz, James C Sanders, Daniela Schmidt, Olaf Prante, Tobias Bäuerle, Alexander Cavallaro, Michael Uder, Bernd Wullich, Peter Goebell, Torsten Kuwert, Philipp Ritt
BACKGROUND: 99m Tc-MIP-1404 (Progenics Pharmaceuticals, Inc., New York, NY) is a novel, SPECT-compatible99m Tc-labeled PSMA inhibitor for the detection of prostate cancer. We present results of its clinical use in a cohort of 225 men with histologically confirmed prostate cancer referred for workup of biochemical relapse. METHODS: From April 2013 to April 2017,99m Tc-MIP1404-scintigraphy was performed in 225 patients for workup of PSA biochemical relapse of prostate cancer...
January 2018: Prostate
https://www.readbyqxmd.com/read/29079120/evaluation-of-delivery-costs-for-external-beam-radiation-therapy-and-brachytherapy-for-locally-advanced-cervical-cancer-using-time-driven-activity-based-costing
#20
Kristine Bauer-Nilsen, Colin Hill, Daniel M Trifiletti, Bruce Libby, Donna H Lash, Melody Lain, Deborah Christodoulou, Constance Hodge, Timothy N Showalter
PURPOSE: To evaluate the delivery costs, using time-driven activity-based costing, and reimbursement for definitive radiation therapy for locally advanced cervical cancer. METHODS AND MATERIALS: Process maps were created to represent each step of the radiation treatment process and included personnel, equipment, and consumable supplies used to deliver care. Personnel were interviewed to estimate time involved to deliver care. Salary data, equipment purchasing information, and facilities costs were also obtained...
January 1, 2018: International Journal of Radiation Oncology, Biology, Physics
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