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https://www.readbyqxmd.com/read/28522645/real-life-gh-dosing-patterns-in-children-with-ghd-ts-or-born-sga-a-report-from-the-nordinet%C3%A2-international-outcome-study
#1
Oliver Blankenstein, Marta Snajderova, Joanne C Blair, Effie Pournara, Birgitte Tønnes Pedersen, Isabelle Oliver Petit
OBJECTIVE: To describe real-life dosing patterns in children with growth hormone deficiency (GHD), born small for gestational age (SGA) or with Turner syndrome (TS) receiving growth hormone (GH) and enrolled in the NordiNet® International Outcome Study (IOS; NCT00960128) between 2006 and 2016. DESIGN: This non-interventional, multicentre study included paediatric patients diagnosed with GHD (isolated [IGHD] or multiple pituitary hormone deficiency [MPHD]), born SGA or with TS and treated according to everyday clinical practice from the Czech Republic (IGHD/MPHD/SGA/TS: n=425/61/316/119), France (n=1404/188/970/206), Germany (n=2603/351/1387/411) and the UK (n=259/60/87/35)...
May 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28518220/postdonation-iron-replacement-for-maintaining-iron-stores-in-female-whole-blood-donors-in-routine-donor-practice-results-of-two-feasibility-studies-in-australia
#2
Sant-Rayn Pasricha, Denese C Marks, Hannah Salvin, Tania Brama, Anthony J Keller, Joanne Pink, Joanna Speedy
BACKGROUND: Iron deficiency represents a risk to donor health and the blood supply. Efficacy trials indicate that postdonation iron replacement improves iron stores but they do not account for complexities of implementation in the routine collection context. We therefore conducted two prospective feasibility studies in Australian donor centers. STUDY DESIGN AND METHODS: In both studies we recruited female donors between 18 and 45 years who had made at least one donation in the previous 12 months...
May 18, 2017: Transfusion
https://www.readbyqxmd.com/read/28498220/patient-presentations-and-medical-logistics-at-full-and-half-ironman-distance-triathlons
#3
Sheila A Turris, Adam Lund, Ron R Bowles, Michael Camporese, Tom Green
We describe logistical challenges, illness/injury rates, as well as medical and ambulance transfer rates (ATR) at an annual large-scale half/full triathlon in a remote location. Prospective observational study; registry data. Data on patient presentation rates, percentage of patients transferred by ambulance, transfer to hospital rates (TTHR), ATR, and medical usage rates were collected and analyzed. In total, 1923 athletes participated in the 2016 triathlon (1404 in the full-length race and 519 in the half) and 181 patient encounters were documented...
May 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28455178/the-patient-experience-an-analysis-of-orthopedic-surgeon-quality-on-physician-rating-sites
#4
REVIEW
Prem N Ramkumar, Sergio M Navarro, Morad Chughtai, Ton La, Evan Fisch, Michael A Mont
BACKGROUND: With the advent of the Consensus Core of Orthopedic Measures, arthroplasty surgeons are increasingly subjected to public performance reviews on physician-rating sites. Therefore, we evaluated (1) web site details of physician-rating sites, (2) differences between sites and the Consensus Core, (3) published patient experiences, (4) search rank among sites, and (5) differences between academic vs nonacademic and arthroplasty vs nonarthroplasty surgeons. METHODS: The 5 busiest physician-rating sites were analyzed...
April 4, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28428159/development-of-a-culturally-tailored-text-message-maternal-health-program-textmatch
#5
Rosie Dobson, Robyn Whittaker, Hannah Bartley, Augusta Connor, Ruyan Chen, Mairead Ross, Judith McCool
BACKGROUND: Mobile phones are increasingly being used to deliver health information and health services globally. Mobile health (mHealth) interventions may be well-suited for minority groups with greater barriers to accessing traditional health services. However, little has been written about the process of culturally adapting interventions for multiple ethnic and cultural minorities within a population. OBJECTIVE: This study describes the process of developing a culturally tailored text message-based maternal health program (TextMATCH: Text for MATernal and Child Health) for Māori, Pacific, Asian, and South Asian families living in New Zealand...
April 20, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28408709/heritability-of-the-severity-of-the-metabolic-syndrome-in-whites-and-blacks-in-3-large-cohorts
#6
Solomon K Musani, Lisa J Martin, Jessica G Woo, Michael Olivier, Matthew J Gurka, Mark D DeBoer
BACKGROUND: Although dichotomous criteria for the metabolic syndrome (MetS) appear heritable, it is not known whether MetS severity as assessed by a continuous MetS score is heritable and whether this varies by race. METHODS AND RESULTS: We used SOLAR (Sequential Oligogenic Linkage Analysis Routines) to evaluate heritability of Adult Treatment Panel-III MetS and a sex- and race-specific MetS severity Z score among 3 large familial cohorts: the JHS (Jackson Heart Study, 1404 black participants), TOPS (Take Off Pounds Sensibly, 1947 white participants), and PLRS (Princeton Lipid Research Study, 229 black and 527 white participants)...
April 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28394707/sociodemographic-and-clinical-risk-factors-associated-with-tuberculosis-mortality-in-the-united-states-2009-2013
#7
Haylea A Hannah, Roque Miramontes, Neel R Gandhi
OBJECTIVES: The objectives of our study were (1) to determine risk factors associated with tuberculosis (TB)-specific and non-TB-specific mortality among patients with TB and (2) to examine whether risk factors for TB-specific mortality differed from those for non-TB-specific mortality. METHODS: We obtained data from the National Tuberculosis Surveillance System and included all patients who had TB between 2009 and 2013 in the United States and its territories. We used multinomial logistic regression analysis to determine the adjusted odds ratio (aOR) of each risk factor for TB-specific and non-TB-specific mortality...
May 2017: Public Health Reports
https://www.readbyqxmd.com/read/28340855/no-mediating-effects-of-glycemic-control-and-inflammation-on-the-association-between-vitamin-d-and-lung-function-in-the-general-population
#8
Anne Kaul, Sven Gläser, Anke Hannemann, Beate Stubbe, Stefan B Felix, Matthias Nauck, Ralf Ewert, Nele Friedrich
BACKGROUND: Vitamin D deficiency is discussed to be associated with lung health. While former studies focused on subjects suffering from pulmonary diseases, we aimed to investigate the association of 25-hydroxy vitamin D [25(OH)D] with lung function in the general population and examined whether mediating effects of inflammation, glycemic control or renal function exist. METHODS: 1404 participants from the Study of Health in Pomerania with pulmonary function testing assessed by expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity and Krogh index were used...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28327445/nine-differentially-expressed-genes-from-a-post-mortem-study-and-their-association-with-suicidal-status-in-a-sample-of-suicide-completers-attempters-and-controls
#9
Martina Balestri, Concetta Crisafulli, Luigi Donato, Ina Giegling, Raffaella Calati, Niki Antypa, Barbara Schneider, Dragan Marusic, Maria Eugenia Tarozzi, Dorjan Marusic, Metka Paragi, Annette M Hartmann, Bettina Konte, Agnese Marsano, Alessandro Serretti, Dan Rujescu
Several lines of evidence indicate that suicidal behaviour is partly heritable, with multiple genes implicated in its aetiology. We focused on nine genes (S100A13, EFEMP1, PCDHB5, PDGFRB, CDCA7L, SCN2B, PTPRR, MLC1 and ZFP36) which we previously detected as differentially expressed in the cortex of suicide victims compared to controls. We investigated 84 variants within these genes in 495 suicidal subjects (299 completers and 196 attempters) and 1513 controls (109 post-mortem and 1404 healthy). We evaluated associations with: 1) suicidal phenotype; 2) possible endophenotypes for suicidal behaviour...
March 10, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28302763/phase-2-study-of-99m-tc-trofolastat-spect-ct-to-identify-and-localize-prostate-cancer-in-intermediate-and-high-risk-patients-undergoing-radical-prostatectomy-and-extended-pelvic-lymph-node-dissection
#10
Karolien E Goffin, Steven Joniau, Peter Tenke, Kevin Slawin, Eric A Klein, Nancy Stambler, Thomas Strack, John Babich, Thomas Armor, Vivien Wong
Rationale:(99m)Tc-trofolastat ((99m)Tc-MIP-1404), a small-molecule inhibitor of prostate-specific membrane antigen (PSMA), shows high potential to detect prostate cancer (PCa) non-invasively using single-photon-emission-computed-tomography (SPECT). We therefore wanted to assess the performance of (99m)Tc-trofolastat SPECT/CT in a phase 2 multi-center, multi-reader prospective study in patients with intermediate- and high-grade PCa, prior to radical prostatectomy and extended pelvic lymph node dissection, with histopathology as gold standard...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28270338/satisfaction-with-sex-life-among-patients-with-schizophrenia
#11
Neelam Laxhman, Lauren Greenberg, Stefan Priebe
BACKGROUND: Whilst subjective quality of life has been extensively studied in patients with schizophrenia, little is known specifically about their satisfaction with their sex lives. Aim To assess the level of satisfaction with sex lives of patients with schizophrenia and explore patient characteristics associated with lower satisfaction. METHOD: Data of five independent samples of patients with schizophrenia or related disorders (ICD-10 F20-29) were analysed. Quality of life including satisfaction with sex life was assessed on the Manchester Short Assessment of Quality of Life...
March 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28228505/postdiagnostic-mediterranean-and-healthy-nordic-dietary-patterns-are-inversely-associated-with-all-cause-mortality-in-long-term-colorectal-cancer-survivors
#12
Ilka Ratjen, Clemens Schafmayer, Romina di Giuseppe, Sabina Waniek, Sandra Plachta-Danielzik, Manja Koch, Ute Nöthlings, Jochen Hampe, Sabrina Schlesinger, Wolfgang Lieb
Background: Dietary factors are known to affect the risk of new-onset colorectal cancer (CRC), but information on the extent to which postdiagnostic diet affects mortality in long-term CRC survivors is scarce.Objective: We investigated the association of 2 a priori-defined postdiagnostic dietary patterns [Modified Mediterranean Diet Score (MMDS) and healthy Nordic Food Index (HNFI)] with all-cause mortality in long-term CRC survivors.Methods: Diet was assessed at a median time of 6 y after cancer diagnosis in 1404 CRC survivors (median age: 69 y; 56% men) in a prospective cohort study in Northern Germany by using a semiquantitative food-frequency questionnaire...
February 22, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28095557/the-photodynamic-therapy-experience-of-a-high-volume-laser-and-dermatologic-surgery-center
#13
David E Orbuch, Lauren Penn, Bradley S Bloom, Jeremy A Brauer, Daniel B Shin, Joshua Greenbaum, Leonard J Bernstein, Elliot T Weiss, Robert T Anolik, Roy G Geronemus
BACKGROUND: Photodynamic therapy (PDT) is an FDA approved treatment for actinic keratoses (AK's) although multiple off-label indi- cations are reported. Despite frequent use for AK's, no clear consensus exists regarding protocols for overall treatment parameters. METHODS: Retrospective chart review of 1,491 subjects who underwent PDT between 2007 and 2011 at a high volume laser surgery center. Demographic information, clinical history, treatment data, and subsequent diagnosis of skin cancers were recorded...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28088341/evaluation-of-an-in-house-indirect-elisa-for-detection-of-antibody-against-haemorrhagic-septicemia-in-asian-elephants
#14
Pallop Tankaew, Thawatchai Singh-La, Chatchote Titaram, Veerasak Punyapornwittaya, Preeyanat Vongchan, Takuo Sawada, Nattawooti Sthitmatee
Pasteurella multocida causes haemorrhagic septicemia in livestock and wild animals, including elephants. The disease has been reported in Asian elephants in India and Sri Lanka, but to date there have been no reported cases in Thailand. ELISA or indirect hemagglutination assays (IHA) have been demonstrated to be able to detect the antibody against the disease in cattle, but no data are available for elephants. The present study reports a novel in-house indirect ELISA for antibody detection of haemorrhagic septicemia in Asian elephants, and evaluates the sensitivity and specificity of the method using a Bayesian approach...
January 12, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28052186/axillary-treatment-for-operable-primary-breast-cancer
#15
REVIEW
Nathan Bromham, Mia Schmidt-Hansen, Margaret Astin, Elise Hasler, Malcolm W Reed
BACKGROUND: Axillary surgery is an established part of the management of primary breast cancer. It provides staging information to guide adjuvant therapy and potentially local control of axillary disease. Several alternative approaches to axillary surgery are available, most of which aim to spare a proportion of women the morbidity of complete axillary dissection. OBJECTIVES: To assess the benefits and harms of alternative approaches to axillary surgery (including omitting such surgery altogether) in terms of overall survival; local, regional and distant recurrences; and adverse events...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28031538/variants-in-microrna-genes-in-familial-papillary-thyroid-carcinoma
#16
Jerneja Tomsic, Rebecca Fultz, Sandya Liyanarachchi, Luke K Genutis, Yanqiang Wang, Wei Li, Stefano Volinia, Krystian Jazdzewski, Huiling He, Paul E Wakely, Leigha Senter, Albert de la Chapelle
Papillary Thyroid Carcinoma (PTC) displays one of the highest familiality scores of all cancers as measured by case-control studies, yet only a handful of genes have been implicated until now. Variants in microRNAs have been associated with the risk of several cancers including PTC but the magnitude of this involvement is unclear. This study was designed to test to what extent genomic variants in microRNAs contribute to PTC risk. We used SOLiD technology to sequence 321 genomic regions encoding 427 miRNAs in one affected individual from each of 80 PTC families...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28005558/residual-thromboxane-activity-and-oxidative-stress-influence-on-mortality-in-patients-with-stable-coronary-artery-disease
#17
Anupama Vasudevan, Teodoro Bottiglieri, Kristen M Tecson, Mohanakrishnan Sathyamoorthy, Jeffrey M Schussler, Carlos E Velasco, Luis R Lopez, Caren Swift, Margarita Peterson, Jeanna Bennett-Firmin, Raphael Schiffmann, Peter A McCullough
BACKGROUND: Aspirin use is effective in the prevention of cardiovascular disease; however, not all patients are equally responsive to aspirin. Oxidative stress reflected by F2-isoprostane [8-iso-prostaglandin-F2α (8-IsoPGF2α)] is a potential mechanism of failure of aspirin to adequately inhibit cyclooxygenase-1. The objective was to examine the relation between all-cause mortality and the concentrations of urinary 11-dehydro thromboxane B2 (11dhTxB2) and 8-IsoPGF2α in patients with stable coronary artery disease (CAD)...
June 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28000444/diagnosis-and-classification-of-17-diseases-from-1404-subjects-via-pattern-analysis-of-exhaled-molecules
#18
Morad K Nakhleh, Haitham Amal, Raneen Jeries, Yoav Y Broza, Manal Aboud, Alaa Gharra, Hodaya Ivgi, Salam Khatib, Shifaa Badarneh, Lior Har-Shai, Lea Glass-Marmor, Izabella Lejbkowicz, Ariel Miller, Samih Badarny, Raz Winer, John Finberg, Sylvia Cohen-Kaminsky, Frédéric Perros, David Montani, Barbara Girerd, Gilles Garcia, Gérald Simonneau, Farid Nakhoul, Shira Baram, Raed Salim, Marwan Hakim, Maayan Gruber, Ohad Ronen, Tal Marshak, Ilana Doweck, Ofer Nativ, Zaher Bahouth, Da-You Shi, Wei Zhang, Qing-Ling Hua, Yue-Yin Pan, Li Tao, Hu Liu, Amir Karban, Eduard Koifman, Tova Rainis, Roberts Skapars, Armands Sivins, Guntis Ancans, Inta Liepniece-Karele, Ilze Kikuste, Ieva Lasina, Ivars Tolmanis, Douglas Johnson, Stuart Z Millstone, Jennifer Fulton, John W Wells, Larry H Wilf, Marc Humbert, Marcis Leja, Nir Peled, Hossam Haick
We report on an artificially intelligent nanoarray based on molecularly modified gold nanoparticles and a random network of single-walled carbon nanotubes for noninvasive diagnosis and classification of a number of diseases from exhaled breath. The performance of this artificially intelligent nanoarray was clinically assessed on breath samples collected from 1404 subjects having one of 17 different disease conditions included in the study or having no evidence of any disease (healthy controls). Blind experiments showed that 86% accuracy could be achieved with the artificially intelligent nanoarray, allowing both detection and discrimination between the different disease conditions examined...
January 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/27982068/the-management-and-prognostic-prediction-of-adenocarcinoma-of-appendix
#19
Xin Xie, Zhangjian Zhou, Yongchun Song, Wenhan Li, Dongmei Diao, Chengxue Dang, Hao Zhang
Malignant tumours of the appendix are quite rare, especially appendiceal adenocarcinomas, which may be difficult to detect preoperatively or intraoperatively. We collected data for 1404 patients with adenocarcinoma of the appendix from the Surveillance, Epidemiology, and End Results Program (SEER) database to explore the potential associations between clinicopathological factors and overall survival. Furthermore, a novel nomogram for predicting prognosis was developed based on our analysis of the SEER data...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27941764/gvhd-after-umbilical-cord-blood-transplantation-for-acute-leukemia-an-analysis-of-risk-factors-and-effect-on-outcomes
#20
Y-B Chen, T Wang, M T Hemmer, C Brady, D R Couriel, A Alousi, J Pidala, A Urbano-Ispizua, S W Choi, T Nishihori, T Teshima, Y Inamoto, B Wirk, D I Marks, H Abdel-Azim, L Lehmann, L Yu, M Bitan, M S Cairo, M Qayed, R Salit, R P Gale, R Martino, S Jaglowski, A Bajel, B Savani, H Frangoul, I D Lewis, J Storek, M Askar, M A Kharfan-Dabaja, M Aljurf, O Ringden, R Reshef, R F Olsson, S Hashmi, S Seo, T R Spitzer, M L MacMillan, A Lazaryan, S R Spellman, M Arora, C S Cutler
Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, we analyzed 1404 umbilical cord blood transplantation (UCBT) patients (single (<18 years)=810, double (⩾18 years)=594) with acute leukemia to define the incidence of acute GvHD (aGvHD) and chronic GvHD (cGvHD), analyze clinical risk factors and investigate outcomes. After single UCBT, 100-day incidence of grade II-IV aGvHD was 39% (95% confidence interval (CI), 36-43%), grade III-IV aGvHD was 18% (95% CI, 15-20%) and 1-year cGvHD was 27% (95% CI, 24-30%)...
March 2017: Bone Marrow Transplantation
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