Deng Wang, Genyu Du, Xinyu Chen, Jinming Wang, Kaiyuan Liu, Huifang Zhao, Chaping Cheng, Yuman He, Na Jing, Penghui Xu, Wei Bao, Xialian Xi, Yingchao Zhang, Nan Wang, Yiyun Liu, Yujiao Sun, Kai Zhang, Pengcheng Zhang, Wei-Qiang Gao, Helen He Zhu
Cell plasticity has been found to play a critical role in tumor progression and therapy resistance. However, our understanding of the characteristics and markers of plastic cellular states during cancer cell lineage transition remains limited. In this study, multi-omics analyses show that prostate cancer cells undergo an intermediate state marked by Zeb1 expression with epithelial-mesenchymal transition (EMT), stemness, and neuroendocrine features during the development of neuroendocrine prostate cancer (NEPC)...
April 23, 2024: Cell Death and Differentiation