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https://www.readbyqxmd.com/read/28231498/bone-specific-poly-ethylene-sodium-phosphate-bearing-biodegradable-nanoparticles
#1
Yuya Hirano, Yasuhiko Iwasaki
Chemotherapy is the most reliable treatment for osteoporosis and osseous metastases. To facilitate better drug delivery for bone treatments, a novel preparation of polymeric nanoparticles with high affinity to bone has been prepared. Two-step synthesis of cholesteryl-functionalized poly(ethylene sodium phosphate) (Ch-PEPn·Na) was performed via ring-opening polymerization of cyclic phosphoesters and the demethylation. The molecular weight of Ch-PEPn·Na could be well controlled by changing the ratio of cholesterol and cyclic phosphoesters...
February 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28229216/enhanced-biotransformation-of-triclocarban-by-ochrobactrum-sp-tcc-1-under-anoxic-nitrate-respiration-conditions
#2
Hui Yun, Bin Liang, Deyong Kong, Zhiling Li, Guoshu Qi, Aijie Wang
Antimicrobial triclocarban (3,4,4'-trichlorocarbanilide, TCC) is frequently detected in soils and sediments for the widely reclaim of sewage sludge or biosolid in recent decades. This resulted from a weak removal of TCC during wastewater treatment, and most of it adsorbed onto sewage sludge. As the toxicity and persistence of TCC in the environment, the elimination of TCC from the source of output is of great importance, particularly in anoxic process. In this study, the biotransformation of TCC by a newly isolated TCC-degrading strain Ochrobactrum sp...
February 22, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28229138/eawag-soil-in-envipath-a-new-resource-for-exploring-regulatory-pesticide-soil-biodegradation-pathways-and-half-life-data
#3
Diogo A R S Latino, Jörg Wicker, Martin Gütlein, Emanuel Schmid, Stefan Kramer, Kathrin Fenner
Developing models for the prediction of microbial biotransformation pathways and half-lives of trace organic contaminants in different environments requires as training data easily accessible and sufficiently large collections of respective biotransformation data that are annotated with metadata on study conditions. Here, we present the Eawag-Soil package, a public database that has been developed to contain all freely accessible regulatory data on pesticide degradation in laboratory soil simulation studies for pesticides registered in the EU (282 degradation pathways, 1535 reactions, 1619 compounds and 4716 biotransformation half-life values with corresponding metadata on study conditions)...
February 23, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28228932/a-clinically-relevant-in-vivo-model-for-the-assessment-of-scaffold-efficacy-in-abdominal-wall-reconstruction
#4
Jeffrey Cy Chan, Krishna Burugapalli, Yi-Shiang Huang, John L Kelly, Abhay Pandit
An animal model that allows for assessment of the degree of stretching or contraction of the implant area and the in vivo degradation properties of biological meshes is required to evaluate their performance in vivo. Adult New Zealand rabbits underwent full thickness subtotal unilateral rectus abdominis muscle excision and were reconstructed with the non-biodegradable Peri-Guard(®), Prolene(®) or biodegradable Surgisis(®) meshes. Following 8 weeks of recovery, the anterior abdominal wall tissue samples were collected for measurement of the implant dimensions...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28228001/fabrication-of-progesterone-loaded-nanofibers-for-the-drug-delivery-applications-in-bovine
#5
Chitra Karuppannan, Mehnath Sivaraj, J Ganesh Kumar, Rangasamy Seerangan, S Balasubramanian, Dhinakar Raj Gopal
Progesterone is a potent drug for synchronization of the estrus and ovulation cycles in bovine. At present, the estrus cycle of bovine is controlled by the insertion of progesterone-embedded silicone bands. The disadvantage of nondegradable polymer inserts is to require for disposal of these bands after their use. The study currently focuses on preparation of biodegradable progesterone-incorporated nanofiber for estrus synchronization. Three different concentrations (1.2, 1.9, and 2.5 g) of progesterone-impregnated nanofibers were fabricated using electrospinning...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28226376/hyaluronic-acid-fillers-in-soft-tissue-regeneration
#6
Arianna Fallacara, Stefano Manfredini, Elisa Durini, Silvia Vertuani
Over the last years, hyaluronic acid (HA) injectable dermal fillers (DFs) have become the most popular agents for soft tissue contouring and volumizing. HA fillers are characterized by most of the properties that an ideal DF should have, due to HA unique chemical-physical properties, biocompatibility, biodegradability, and versatility. Therefore, HA DFs have revolutionized the filler market with a high number of products, which differ in terms of HA source, cross-linkage (agent and degree), HA concentration, hardness, cohesivity, consistency, inclusion or lack of anesthetic, indication, and longevity of correction...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28226244/molecularly-organic-inorganic-hybrid-hollow-mesoporous-organosilica-nanocapsules-with-tumor-specific-biodegradability-and-enhanced-chemotherapeutic-functionality
#7
Ping Huang, Yu Chen, Han Lin, Luodan Yu, Linlin Zhang, Liying Wang, Yufang Zhu, Jianlin Shi
Based on the intrinsic features of high stability and unique multifunctionality, inorganic nanoparticles have shown remarkable potentials in combating cancer, but their biodegradability and biocompatibility are still under debate. As a paradigm, this work successfully demonstrates that framework organic-inorganic hybridization can endow the inorganic mesoporous silica nanocarriers with unique tumor-sensitive biodegradability and high biocompatibility. Based on a "chemical homology" mechanism, molecularly organic-inorganic hybridized hollow mesoporous organosilica nanocapsules (HMONs) with high dispersity and sub-50 nm particle dimension were constructed in mass production...
February 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28225273/fabric-softener-cellulose-nanocrystal-interaction-a-model-for-assessing-surfactant-deposition-on-cotton
#8
Evdokia K Oikonomou, Fanny Mousseau, Nikolay Christov, Galder Cristobal, Annie Vacher, Marc Airiau, Claudie Bourgaux, Laurent Heux, Jean-François Berret
There is currently a renewed interest for improving household and personal care formulations to provide more environment friendly products. Fabric conditioners used as softeners have to fulfill a number of stability and biodegradability requirements. They should also display significant adsorption on cotton in the conditions of use. The quantification of surfactant adsorption remains however difficult because the fabric woven structure is complex and deposited amounts are generally small. Here we propose a method to evaluate cellulose/surfactant interactions with increased detection sensitivity...
February 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28224884/water-soluble-co-polyelectrolytes-by-selective-modification-of-cellulose-esters
#9
Shu Liu, Kevin J Edgar
Cellulose-based materials are well-suited for biomedical uses, because of their abundance, renewable nature, biodegradability, and relatively low cost. However, the set of commercially available cellulose esters and ethers is limited in number and diversity, and contains no cationically charged cellulose esters. Herein we report a simple, efficient strategy for synthesizing cationic, water-soluble co-polyelectrolytes from commercial, hydrophobic, renewable-based cellulose esters. Cellulose acetate (degree of substitution (DS) 1...
April 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28224390/plga-nanoparticles-as-subconjunctival-injection-for-management-of-glaucoma
#10
Hamed A Salama, Mahmoud Ghorab, Azza A Mahmoud, Mayssa Abdel Hady
Nanoparticles fabricated from the biodegradable and biocompatible polymer, polylactic-co-glycolic acid (PLGA), could be a promising system for targeting ocular drug delivery. The objective of this work was to investigate the possibility of encapsulating brinzolamide in PLGA nanoparticles in order to be applied as a subconjunctival injection that could represent a starting point for developing new therapeutic strategies against increase in ocular pressure. The brinzolamide-loaded PLGA nanoparticles were fabricated using emulsion-diffusion-evaporation method with varying concentrations of Tween 80 or poloxamer 188 (Plx) in aqueous and organic phases...
February 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28223801/phytobioactive-compound-based-nanodelivery-systems-for-the-treatment-of-type-2-diabetes-mellitus-current-status
#11
REVIEW
Palanivel Ganesan, Palanisamy Arulselvan, Dong-Kug Choi
Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28223798/transferrin-receptor-targeted-ph-sensitive-micellar-system-for-diminution-of-drug-resistance-and-targetable-delivery-in-multidrug-resistant-breast-cancer
#12
Wei Gao, Guihua Ye, Xiaochuan Duan, Xiaoying Yang, Victor C Yang
The emergence of drug resistance is partially associated with overproduction of transferrin receptor (TfR). To overcome multidrug resistance (MDR) and achieve tumor target delivery, we designed a novel biodegradable pH-sensitive micellar system modified with HAIYPRH, a TfR ligand (7pep). First, the polymers poly(l-histidine)-coupled polyethylene glycol-2000 (PHIS-PEG2000) and 7pep-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (7pep-DSPE-PEG2000) were synthesized, and the mixed micelles were prepared by blending of PHIS-PEG2000 and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (DSPE-PEG2000) or 7pep-DSPE-PEG2000 (7-pep HD micelles)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28223209/langmuir-schaefer-film-deposition-onto-honeycomb-porous-films-for-retinal-tissue-engineering
#13
Maria Teresa Calejo, Tanja Ilmarinen, Elina Vuorimaa-Laukkanen, Elina Talvitie, Hanna M Hakola, Heli Skottman, Minna Kellomäki
: Age-related macular degeneration (AMD) is the leading cause of vision loss in senior citizens in the developed world. The disease is characterised by the degeneration of a specific cell layer at the back of the eye - the retinal pigment epithelium (RPE), which is essential in retinal function. The most promising therapeutic option to restore the lost vision is considered to be RPE cell transplantation. This work focuses on the development of biodegradable biomaterials with similar properties to the native Bruch's membrane as carriers for RPE cells...
February 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28223133/bio-based-materials-with-novel-characteristics-for-tissue-engineering-applications-a-review
#14
REVIEW
Luis Bedian, Angel M Villalba-Rodríguez, Gustavo Hernández-Vargas, Roberto Parra-Saldivar, Hafiz M N Iqbal
Recently, a wider spectrum of bio-based materials and materials-based novel constructs and systems has been engineered with high interests. The key objective is to help for an enhanced/better quality of life in a secure way by avoiding/limiting various adverse effects of some in practice traditional therapies. In this context, different methodological approaches including in vitro, in vivo, and ex vivo techniques have been exploited, so far. Among them, bio-based therapeutic constructs are of supreme interests for an enhanced and efficient delivery in the current biomedical sector of the modern world...
February 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28220461/new-generation-coronary-stents-current-data-and-future-directions
#15
REVIEW
Ankur Kalra, Hasan Rehman, Sahil Khera, Braghadheeswar Thyagarajan, Deepak L Bhatt, Neal S Kleiman, Robert W Yeh
PURPOSE OF REVIEW: Drug-eluting stents are the mainstay in the treatment of coronary artery disease using percutaneous coronary intervention. Innovations developed to overcome the limitations of prior generations of stents include biodegradable polymer stents, drug-eluting stents without a polymer, and bioabsorbable scaffolds. Our review briefly discusses the clinical profiles of first- and second-generation coronary stents, and provides an up-to-date overview of design, technology, and clinical safety and efficacy profiles of newer generation coronary stents discussing the relevant clinical trials in this rapidly evolving area of interventional cardiology...
March 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28220167/dynamical-descriptors-of-bioactivity-a-correlation-between-chemical-durability-and-ion-migration-in-biodegradable-glasses
#16
Antonio Tilocca
Ion migration in two fluorinated bioactive glasses of significantly different durability was modeled through molecular dynamics simulations. Whereas the very different biodegradation of these glasses cannot be explained on the basis of their structural features alone, the analysis of the diffusive data highlights a strong connection between the glass durability determined experimentally and the activation barriers for ion diffusion extracted by the simulations, clarifying the source of the different solubility and suggesting that "dynamical" descriptors of bioactivity could represent a key tool to predict the macroscopic behavior of a biomaterial, in some cases more effectively than with the current structural descriptors...
February 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28220138/de-novo-transcriptome-assembly-of-phomopsis-liquidambari-provides-insights-into-genes-associated-with-different-lifestyles-in-rice-oryza-sativa-l
#17
Jun Zhou, Xin Li, Yan Chen, Chuan-Chao Dai
The mechanisms that trigger the switch from endophytic fungi to saprophytic fungi are largely unexplored. Broad host range Phomopsis liquidambari is established in endophytic and saprophytic systems with rice (Oryza sativa L.). Endophytic P. liquidambari promotes rice growth, increasing rice yield and improving the efficiency of nitrogen fertilizer. This species's saprophytic counterpart can decompose rice litterfall, promoting litter organic matter cycling and the release of nutrients and improving the soil microbial environment...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28219808/photoluminescent-and-biodegradable-polycitrate-polyethylene-glycol-polyethyleneimine-polymers-as-highly-biocompatible-and-efficient-vectors-for-bioimaging-guided-sirna-and-mirna-delivery
#18
Min Wang, Yi Guo, Meng Yu, Peter X Ma, Cong Mao, Bo Lei
: Development of biodegradable and biocompatible non-viral vectors with intrinsical multifunctional properties such as bioimaging ability for highly efficient nucleic acids delivery still remains a challenge. Here, a biodegradable poly (1, 8-octanedio-citric acid)-co-polyethylene glycol grafted with polyethyleneimine (PEI) (POCG-PEI) polymers with the photoluminescent capacity were synthesized for nucleic acids delivery (siRNA and miRNA). POCG-PEI polymers can efficiently bind various nucleic acids, protect them against enzymatic degradation and release the genes in the presence of polyanionic heparin...
February 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28216654/performance-kinetic-and-biodegradation-pathway-evaluation-of-anaerobic-fixed-film-fixed-bed-reactor-in-removing-phthalic-acid-esters-from-wastewater
#19
Ehsan Ahmadi, Samira Yousefzadeh, Mohsen Ansari, Hamid Reza Ghaffari, Ali Azari, Mohammad Miri, Alireza Mesdaghinia, Ramin Nabizadeh, Babak Kakavandi, Peyman Ahmadi, Mojtaba Yegane Badi, Mitra Gholami, Kiomars Sharafi, Mostafa Karimaei, Mahboobeh Ghoochani, Masoud Binesh Brahmand, Seyed Mohsen Mohseni, Maryam Sarkhosh, Soheila Rezaei, Hosseinali Asgharnia, Emad Dehghanifard, Behdad Jafari, Alireza Mortezapour, Vahid Kazemi Moghaddam, Mohammad Molla Mahmoudi, Nader Taghipour
Emerging and hazardous environmental pollutants like phthalic acid esters (PAEs) are one of the recent concerns worldwide. PAEs are considered to have diverse endocrine disrupting effects on human health. Industrial wastewater has been reported as an important environment with high concentrations of PAEs. In the present study, four short-chain PAEs including diallyl phthalate (DAP), diethyl phthalate (DEP), dimethyl phthalate (DMP), and phthalic acid (PA) were selected as a substrate for anaerobic fixed film fixed bed reactor (AnFFFBR)...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216559/aloe-vera-for-tissue-engineering-applications
#20
REVIEW
Shekh Rahman, Princeton Carter, Narayan Bhattarai
Aloe vera, also referred as Aloe barbadensis Miller, is a succulent plant widely used for biomedical, pharmaceutical and cosmetic applications. Aloe vera has been used for thousands of years. However, recent significant advances have been made in the development of aloe vera for tissue engineering applications. Aloe vera has received considerable attention in tissue engineering due to its biodegradability, biocompatibility, and low toxicity properties. Aloe vera has been reported to have many biologically active components...
February 14, 2017: Journal of Functional Biomaterials
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