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Bioabsorbable scaffolds

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https://www.readbyqxmd.com/read/27807948/procedural-resources-utilization-and-clinical-outcomes-with-bioresorbable-everolimus-eluting-scaffolds-and-pt-cr-everolimus-eluting-stent-with-resorbable-abluminal-polymer-in-clinical-practice-a-randomized-trial
#1
Jose M de la Torre Hernandez, Tamara Garcia Camarero, Dae-Hyun Lee, Fermin Sainz Laso, Gabriela Veiga Fernandez, Tania Pino, Silvia Rubio, Pablo Legarra, Jorge R Valdivia, Javier Zueco Gil
OBJECTIVES: We sought to compare the procedural implications of using bioresorbable everolimus-eluting scaffolds (BVS) and Pt-Cr everolimus-eluting stent with abluminal bioabsorbable polymer (Synergy). BACKGROUND: There are important differences in the respective platforms, which could impact on procedural performance, complications and outcomes. METHODS: A prospective, randomized single center study including consecutive patients in stable clinical condition and with lesions amenable to be treated with BVS according to predefined criteria...
November 3, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27692818/the-nidus-for-possible-thrombus%C3%A2-formation-insight-from-the-microenvironment-of-bioresorbable-vascular-scaffold
#2
Erhan Tenekecioglu, Eric K W Poon, Carlos Collet, Vikas Thondapu, Ryo Torii, Christos V Bourantas, Yaping Zeng, Yoshinobu Onuma, Andrew S H Ooi, Patrick W Serruys, Peter Barlis
No abstract text is available yet for this article.
October 24, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27629596/development-of-bioresorbable-hydrophilic-hydrophobic-electrospun-scaffolds-for-neural-tissue-engineering
#3
Luanda Chaves Lins, Florence Wianny, Sébastien Livi, Idalba Andreina Hidalgo, Colette Dehay, Jannick Duchet-Rumeau, Jean-François Gérard
In this study, electrospun fiber scaffolds based on biodegradable and bioabsorbable polymers and showing a similar structure to that of the extracellular matrix (ECM) present in the neural tissues were prepared. The effects of electrospun-based scaffolds processed from poly(lactic acid) (PLA)/poly(lactide-b-ethylene glycol-b-lactide) block copolymer (PELA) and PLA/polyethylene glycol (PEG) (50:50 by wt) blends on the morphology, wettability, and mechanical properties, as well as on neural stem cell (NSC) behavior, were investigated...
October 10, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27531492/optical-coherence-tomography-imaging-after-successful-percutaneous-coronary-intervention-treatment-of-coronary-perforation-following-bioabsorbable-vascular-scaffold-implantation-consecutive-ping-pong-and-child-in-mother-techniques
#4
Carlos Cortés, Ignacio J Amat-Santos, Milosz Jaguszewski, Paol Rojas, L Renier Gonçalves, Juan Luis Gutiérrez-Chico, J Alberto San Román
No abstract text is available yet for this article.
2016: Cardiology Journal
https://www.readbyqxmd.com/read/27410952/saphenous-vein-graft-lesions-are-second-generation-drug-eluting-stents-better
#5
EDITORIAL
Dhaval Kolte, J Dawn Abbott
Long-term outcomes were similar in patients treated with first- or second-generation drug-eluting stents (DES) for saphenous vein graft (SVG) lesions. Patients presenting with acute myocardial infarction as a result of occluded SVG may derive some benefit from the use of second- versus first-generation DES Randomized clinical trials are needed to determine whether newer DES types including those with bioabsorbable polymer or scaffolds offer a distinct advantage in the treatment of SVG lesions.
January 1, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27324079/the-use-of-platelet-rich-fibrin-combined-with-periodontal-ligament-and-jaw-bone-mesenchymal-stem-cell-sheets-for-periodontal-tissue-engineering
#6
Zhong-Shan Wang, Zhi-Hong Feng, Guo-Feng Wu, Shi-Zhu Bai, Yan Dong, Fa-Ming Chen, Yi-Min Zhao
Periodontal regeneration involves the restoration of at least three unique tissues: cementum, periodontal ligament tissue (PDL) and alveolar bone tissue. Here, we first isolated human PDL stem cells (PDLSCs) and jaw bone mesenchymal stem cells (JBMSCs). These cells were then induced to form cell sheets using an ascorbic acid-rich approach, and the cell sheet properties, including morphology, thickness and gene expression profile, were compared. Platelet-rich fibrin (PRF) derived from human venous blood was then fabricated into bioabsorbable fibrin scaffolds containing various growth factors...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27301200/12-month-coronary-angiography-intravascular-ultrasound-and-histology-evaluation-of-a-novel-fully-bioabsorbable-poly-l-lactic-acid-amorphous-calcium-phosphate-scaffolds-in-porcine-coronary-arteries
#7
Gaoke Feng, Jianmin Xiao, Yuying Bi, Zhiyuan Lan, Xiaoxin Zheng, Zhao Lu, Jun Li, Kan Wu, Edward Kislauskis, Stephen McCarthy, Qiang Hu, Xuejun Jiang, Tim Wu, Roger Laham
Our previous studies have confirmed the superior biocompatibility of the poly-L-lactic acid/amorphous calcium phosphate (PLLA/ACP) scaffolds (PowerScaffold) compared to PLLA scaffolds and their similar 6-month radial strength compared with TAXUS stents. In order to conduct further dynamic observations on the performance of the PowerScaffold after 12-month implantation compared with the TAXUS stents. Twenty PowerScaffold and 20 TAXUS were implanted in porcine coronary arteries. At 12-month follow-up, Quantitative Coronary Angiography showed that the stent reference vessel diameter (3...
April 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/27293872/bioresorbable-vascular-scaffolds-time-to-vanish
#8
Diego Arroyo, Stéphane Cook, Serban Puricel
The fully bioabsorbable vascular scaffold (BVS) has been developed to reduce late adverse events after coronary stenting such as device thrombosis. The device consists of polylactic acid, which is gradually absorbed within the first few years after its implantation. The initial experience with the device in low-risk patients presenting with simple lesions was satisfying and generated optimism among interventional cardiologists by promising better patient outcomes. However, the unrestricted use of the device in patients presenting with a higher baseline risk and more complex lesions came at the cost of alarmingly high rates of early device thrombosis...
June 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27257022/platelet-reactivity-over-time-in-coronary-artery-disease-patients-treated-with-a-bioabsorbable-everolimus-eluting-scaffold
#9
Antonio Tello-Montoliu, José Rivera, Diana Hernández-Romero, Ana Silvente, Eva Jover, Miriam Quintana, Esteban Orenes-Piñero, José Hurtado, José Luis Ferreiro, Francisco Marín, Mariano Valdés
Everolimus-eluting bioabsorbable scaffolds (BVSs) have exhibited similar long-term clinical outcomes compared to its everolimus-eluting metallic counterparts. However, reports from earlier studies have shown a signal for an increased rate of stent thrombosis. The aim of the current investigation is to describe the platelet reactivity profiles over time in patients treated with everolimus-eluting BVS in comparison to everolimus-eluting metallic stents. This is a pilot study in which patients on aspirin and clopidogrel with at least 1 everolimus-eluting BVS were included (n = 24)...
June 2, 2016: Platelets
https://www.readbyqxmd.com/read/27252652/bioabsorbable-bypass-grafts-biofunctionalised-with-rgd-have-enhanced-biophysical-properties-and-endothelialisation-tested-in-vivo
#10
Larisa V Antonova, Alexander M Seifalian, Anton G Kutikhin, Victoria V Sevostyanova, Evgeniya O Krivkina, Andrey V Mironov, Andrey Y Burago, Elena A Velikanova, Vera G Matveeva, Tatiana V Glushkova, Evgeniya A Sergeeva, Georgiy Y Vasyukov, Yuliya A Kudryavtseva, Olga L Barbarash, Leonid S Barbarash
Small diameter arterial bypass grafts are considered as unmet clinical need since the current grafts have poor patency of 25% within 5 years. We have developed a 3D scaffold manufactured from natural and synthetic biodegradable polymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27249788/radiation-exposure-during-implantation-of-bioabsorbable-vascular-scaffolds-versus-drug-eluting-stents-in-non-complex-coronary-lesions-a-matched-cohort-study
#11
Benedikt Schrage, Moritz Seiffert, Kai MüLLERLEILE, Elvin Zengin, Edith Lubos, Christoph Sinning, Ulrich Schaefer, Karsten Sydow, Stefan Blankenberg, Dirk Westermann
BACKGROUND: Bioabsorbable vascular scaffolds (BVS) are a novel option for the treatment of coronary lesions in patients with stable coronary artery disease or acute coronary syndromes. We aimed to identify the influence of BVS implantation on radiation exposure and procedural outcomes compared to drug eluting stents (DES) in daily clinical practice. METHODS: A retrospective single-centre study was performed in patients undergoing percutaneous coronary intervention with BVS from 2013 to 2014...
June 1, 2016: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/27248371/bioabsorbable-zinc-ion-induced-biphasic-cellular-responses-in-vascular-smooth-muscle-cells
#12
Jun Ma, Nan Zhao, Donghui Zhu
Bioabsorbable metal zinc (Zn) is a promising new generation of implantable scaffold for cardiovascular and orthopedic applications. In cardiovascular stent applications, zinc ion (Zn(2+)) will be gradually released into the surrounding vascular tissues from such Zn-containing scaffolds after implantation. However, the interactions between vascular cells and Zn(2+) are still largely unknown. We explored the short-term effects of extracellular Zn(2+) on human smooth muscle cells (SMCs) up to 24 h, and an interesting biphasic effect of Zn(2+) was observed...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27106472/successful-treatment-of-a-recurrent-wide%C3%A2-tracheoesophageal-fistula-with-a%C3%A2-bioabsorbable-patch
#13
Lucia Battistella, Giuseppe Marulli, Giovanni Maria Comacchio, Marco Mammana, Guido Di Gregorio, Federico Rea
Acquired nonmalignant tracheoesophageal fistula (TEF) is a rare condition that requires proper treatment. We present the case of a 55-year-old woman with a 4.5-cm recurrent TEF, which had developed after an attempted surgical repair. After closure of the esophageal defect in two layers, a tracheoplasty technique was used to repair the tracheal membranous wall with a synthetic bioabsorbable patch (Gore Bio-A tissue reinforcement) covered with an intercostal muscle flap. The use of Gore Bio-A tissue reinforcement is an innovative and effective method to close a wide tracheal defect while achieving a scaffold for epithelial colonization...
May 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27094868/biodegradable-metals-for-cardiovascular-stents-from-clinical-concerns-to-recent-zn-alloys
#14
Patrick K Bowen, Emily R Shearier, Shan Zhao, Roger J Guillory, Feng Zhao, Jeremy Goldman, Jaroslaw W Drelich
Metallic stents are used to promote revascularization and maintain patency of plaqued or damaged arteries following balloon angioplasty. To mitigate the long-term side effects associated with corrosion-resistant stents (i.e., chronic inflammation and late stage thrombosis), a new generation of so-called "bioabsorbable" stents is currently being developed. The bioabsorbable coronary stents will corrode and be absorbed by the artery after completing their task as vascular scaffolding. Research spanning the last two decades has focused on biodegradable polymeric, iron-based, and magnesium-based stent materials...
May 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27045877/outcomes-with-bioabsorbable-vascular-scaffolds-versus-everolimus-eluting-stents-insights-from-randomized-trials
#15
Sripal Bangalore, Bora Toklu, Deepak L Bhatt
BACKGROUND: Bioresorbable vascular scaffolds (BVS) have been shown to be non-inferior to second generation drug eluting stents in recent clinical trials. However, the trials were not powered for individual endpoints and there is concern for increased device thrombosis with BVS. METHODS: We performed a systematic search for randomized clinical trials of BVS versus EES. Efficacy outcomes were target lesion revascularization (TLR) and target vessel revascularization (TVR)...
June 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27029883/-late-structural-discontinuity-and-migration-of-a-bioabsorbable-scaffold-in-a-saphenous-vein-graft
#16
Paolo Sganzerla, Emanuela Tavasci
The use of bioresorbable vascular scaffolds (BVS) has many important and potentially useful features, on both pathophysiological and clinical grounds, for the treatment of native coronary artery stenosis. These advantages are less well established when BVS are employed in saphenous vein graft disease. We here describe a peculiar behavior of a previously (6 months) implanted BVS in a degenerated saphenous vein graft during treatment of an in-stent restenosis in a patient suffering from unstable angina. This BVS particular performance seems to suggest that different pathophysiological and anatomical conditions may play a relevant role in affecting the results of transluminal vascular therapy...
March 2016: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/26905052/outcome-of-everolimus-eluting-bioabsorbable-vascular-scaffold-bvs-compared-to-non-bvs-drug-eluting-stent-in-the-management-of-st-segment-elevation-myocardial-infarction-stemi-a-comparative-study
#17
Rabin Chakraborty, Soumya Patra, Suvro Banerjee, Arindam Pande, Aftab Khan, Prakash Chandra Mandol, Debashish Ghosh, Swapan Kumar De, Sankha Subhro Das, Raja Nag
BACKGROUND: The safety and efficacy of everolimus eluting bioabsorbable vascular scaffold (BVS) in the management of "ST" segment elevation myocardial infarction (STEMI) are yet to be established. AIMS: To evaluate immediate and short term safety and efficacy of the everolimus-eluting ABSORB BVS compared with non BVS drug eluting stent (DES) in patients with STEMI. METHODS: From December 2013 to December 2014, 220 patients with STEMI were included in this study...
April 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/26793967/coronary-artery-aneurysm-after-everolimus-eluting-bioabsorbable-vascular-scaffold-implantation
#18
Swaroop Varghese, Bernward Lauer, Marc-Alexander Ohlow
No abstract text is available yet for this article.
January 25, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/26558339/what-is-the-most-possible-cause-of-the-side-branch-occlusion-after-bioabsorbable-everolimus-eluting-stent-implantation-thickness-of-the-scaffolds-or-large-plaque-burden
#19
LETTER
Tamer Kırat, Nuri Köse, İbrahim Altun, Fatih Akın, Gökhan Ergün, Mustafa Özcan Soylu
No abstract text is available yet for this article.
April 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26538358/slow-chlorine-releasing-compounds-a-viable-sterilisation-method-for-bioabsorbable-nanocomposite-biomaterials
#20
Naghmeh Naderi, Michelle Griffin, Edward Malins, Remzi Becer, Afshin Mosahebi, Iain S Whitaker, Alexander M Seifalian
OBJECTIVE: Selection of the appropriate sterilisation method for biodegradable materials has been a challenging task. Many conventional sterilisation methods are not suitable for the next generation of biomaterials, mainly due to their complex composition, based on nanomaterials, often incorporating bioactive moieties. In this study, we investigate sterilisation efficacy of slow chlorine releasing compound sodium dichloroisocyanurate dihydrate (SDIC) for polyhedral oligomeric silsesquioxane (POSS)-poly(caprolactone urea-urethane) (PCL) scaffolds in comparison with conventional sterilisation methods...
February 2016: Journal of Biomaterials Applications
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