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Bioabsorbable scaffolds

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https://www.readbyqxmd.com/read/29627909/technological-advances-in-stent-therapies-a-year-in-review
#1
REVIEW
Jad Raffoul, Ammar Nasir, Andrew J P Klein
Stent technology has rapidly evolved since the first stainless steel bare metal stents with substantial developments in scaffolding, polymer, drug choice, drug delivery, and elution mechanisms. Most recently, there has been the evolution of bioabsorbable vascular scaffolds, potentially eliminating the need for long-term foreign object retention. These rapid developments have led to an ever-expanding selection of new stents, making the choice of which to use in which patient challenging. Operators must balance potential short- and long-term clinical ramifications, namely stent thrombosis, in-stent restenosis, target lesion revascularization, and target lesion failure...
April 7, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29578542/a-tailorable-in-situ-light-activated-biodegradable-vascular-scaffold
#2
Mazen S Albaghdadi, Jian Yang, Jessica H Brown, Neel A Mansukhani, Guillermo A Ameer, Melina R Kibbe
Biodegradable vascular scaffolds (BVS) are novel treatments for obstructive atherosclerotic cardiovascular disease that have been developed to overcome the limitations of traditional metallic drug-eluting stents (DES). The mechanical properties of bioabsorbable polymers used for the production of novel BVS are a key consideration for the clinical translation of this emerging technology. Herein, we describe the engineering of an in situ light-activated vascular scaffold (ILVS) comprised of a biodegradable citric acid-based elastomeric polymer, referred to as methacrylated poly-diol citrate (mPDC), and a diazeniumdiolate chitosan nitric oxide donor (chitoNO)...
April 2017: Advanced materials technologies
https://www.readbyqxmd.com/read/29530821/zinc-based-alloys-for-degradable-vascular-stent-applications
#3
REVIEW
Ehsan Mostaed, Malgorzata Sikora-Jasinska, Jaroslaw W Drelich, Maurizio Vedani
The search for biodegradable metals with mechanical properties equal or higher to those of currently used permanent biomaterials, such as stainless steels, cobalt chromium and titanium alloys, desirable in vivo degradation rate and uniform corrosion is still an open challenge. Magnesium (Mg), iron (Fe) and zinc (Zn)-based alloys have been proposed as biodegradable metals for medical applications. Over the last two decades, extensive research has been done on Mg and Fe. Fe-based alloys show appropriate mechanical properties, but their degradation rate is an order of magnitude below the benchmark value...
March 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29469029/preclinical-evaluation-of-degradation-kinetics-and-elemental-mapping-of-first-and-second-generation-bioresorbable-magnesium-scaffolds
#4
Michael Joner, Philipp Ruppelt, Philine Zumstein, Capucine Lapointe-Corriveau, Guy Leclerc, Anna Bulin, Maria Isabel Castellanos, Eric Wittchow, Michael Haude, Ron Waksman
AIMS: Because vascular restoration therapy using bioresorbable vascular scaffolds (BRS) remains an appealing concept to restore vasoreactivity, understanding of biodegradation remains paramount during preclinical testing. METHODS AND RESULTS: Qualitative characterization of biodegradation was performed in 41 DREAMS 1G up to 3 years, while degradation kinetics were acquired in 54 DREAMS 2G implanted into porcine coronary arteries for 28, 90 and 180 days, 1 and 2 years...
February 20, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29410803/development-of-bioabsorbable-polylactide-membrane-with-controllable-hydrophilicity-for-adjustment-of-cell-behaviours
#5
Yang Yang, Xiaofeng Qiu, Yi Sun, Yifeng Wang, Jine Wang, Yulin Li, Changsheng Liu
Cell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(d,l-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the hydrophobicity of the membrane (a limiting factor for its biomedical application), an amphiphilic monomethoxyl poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) was selected to improve its surface hydrophilicity through a simple self-assembly approach...
January 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29409057/endothelial-shear-stress-5-years-after-implantation-of-a-coronary-bioresorbable-scaffold
#6
Vikas Thondapu, Erhan Tenekecioglu, Eric K W Poon, Carlos Collet, Ryo Torii, Christos V Bourantas, Cheng Chin, Yohei Sotomi, Hans Jonker, Jouke Dijkstra, Eve Revalor, Frank Gijsen, Yoshinobu Onuma, Andrew Ooi, Peter Barlis, Patrick W Serruys
Aims: As a sine qua non for arterial wall physiology, local hemodynamic forces such as endothelial shear stress (ESS) may influence long-term vessel changes as bioabsorbable scaffolds dissolve. The aim of this study was to perform serial computational fluid dynamic (CFD) simulations to examine immediate and long-term haemodynamic and vascular changes following bioresorbable scaffold placement. Methods and results: Coronary arterial models with long-term serial assessment (baseline and 5 years) were reconstructed through fusion of intravascular optical coherence tomography and angiography...
February 2, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29344373/multianalysis-with-optical-coherence-tomography-and-vasomotion-in-everolimus-eluting-stents-and-everolimus-eluting-biovascular-scaffolds-the-moves-trial
#7
Diego A Arroyo, Sara Schukraft, Zacharenia Kallinikou, Jean-Christophe Stauffer, Gérard Baeriswyl, Jean-Jacques Goy, Mario Togni, Stéphane Cook, Serban Puricel
Aims: To compare endothelium-dependent vasomotor function and vascular healing 15 months after implantation of two new-generation drug-eluting stents and biovascular scaffolds (BVS). Methods and results: A total of 28 patients previously treated with a SYNERGY stent (bioabsorbable polymer everolimus-eluting stents (BP-EES)), a PROMUS stent (persistent polymer everolimus-eluting stents (PP-EES)) or an ABSORB (BVS) underwent control coronary angiography, 15 months after implantation, coupled with optical coherence tomography imaging and supine bicycle exercise...
2018: Open Heart
https://www.readbyqxmd.com/read/29279677/on-the-synthesis-and-characterization-of-%C3%AE-tricalcium-phosphate-scaffolds-coated-with-collagen-or-poly-d-l-lactic-acid-for-alveolar-bone-augmentation
#8
Isadora S Deschamps, Gabriel L Magrin, Ricardo S Magini, Márcio C Fredel, Cesar A M Benfatti, Júlio C M Souza
Objectives: After tooth loss, dimensional alterations on the alveolar bone ridge can occur that can negatively affect the placement of dental implants. The purpose of this study was to evaluate the synthesis, and mechanical properties of β-tricalcium phosphate (β-TCP) scaffolds coated with bioabsorbable polymers, namely, collagen and poly (D, L-lactic acid) (PDLLA). Materials and Methods: β-TCP powder was obtained by reactive milling and then characterized by X-ray diffraction and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDS)...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29278215/percutaneous-coronary-intervention-in-the-elderly-are-drug-coated-balloons-the-future
#9
Ioannis Merinopoulos, Tharusha Gunawardena, Upul Wickramarachchi, Alisdair Ryding, Simon Eccleshall, Vassilios S Vassiliou
BACKGROUND: Balloon angioplasty revolutionised percutaneous treatment for coronary artery disease four decades ago, but vessel-threatening dissections, elastic recoil and restenosis were major drawbacks to an otherwise successful long-lasting intervention. Subsequent advances with bare metal stents and then drug eluting stents followed, aiming to mitigate the risks of acute vessel closure and restenosis. However, stent implantation often necessitates dual antiplatelet therapy for a prolonged period of time, which in itself can lead to adverse outcomes, especially in the frail elderly population at higher risk of bleeding...
March 14, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29157898/radiologic-and-clinical-evaluation-of-a-bioabsorbable-collagen-implant-to-treat-partial-thickness-tears-a-prospective-multicenter-study
#10
Theodore F Schlegel, Jeffrey S Abrams, Brandon D Bushnell, J Logan Brock, Charles P Ho
BACKGROUND: Treatment of partial-thickness cuff tears remains controversial. Although conservative therapy may treat symptoms, these defects do not spontaneously heal and conversion to a full-thickness lesion with subsequent repair may alter the tendon footprint. The ability to induce new tissue formation and limit tear progression in intermediate- and high-grade partial-thickness tears without surgical repair may represent a significant advancement in the treatment paradigm for these lesions...
February 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28975848/bioabsorbable-poly-l-d-lactide-96-4-scaffold-arthroplasty-regjoint%C3%A2-for-trapeziometacarpal-osteoarthritis-a-3-year-follow-up-study
#11
Simo Mattila, Mari Ainola, Eero Waris
The poly-L/D-lactide joint scaffold (RegJoint™) has recently been associated with adverse tissue reactions and osteolysis after partial trapeziectomy for trapeziometacarpal osteoarthritis. Twenty-two of 23 patients previously operated on with this scaffold were re-examined at a mean follow-up of 3.3 years (range 36-53 months). Overall, the results showed an unacceptably high rate of adverse tissue reactions related to the degradation process of the implant, resulting in a revision procedure in three patients...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28970994/arthroscopic-revision-of-medial-rotator-cuff-failure-augmented-with-a-bioabsorbable-patch
#12
Eduard Buess, Michael Hackl, Peter Buxbaumer
When revising failed double-row and suture-bridge rotator cuff repairs medial failures represent a potential feature. In the presence of a compromised healing environment, patch augmentation becomes a logical adjunct from a mechanical and biological point of view. A reproducible step-by-step revision technique is described that reinforces the weak central cuff area with an absorbable synthetic scaffold.
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28945635/comparison-of-stromal-vascular-fraction-with-or-without-a-novel-bioscaffold-to-fibrin-glue-in-a-porcine-model-of-mechanically-induced-anorectal-fistula
#13
Gerald W Dryden, Eugene Boland, Vijay Yajnik, Stuart Williams
BACKGROUND: Anorectal fistulas (ARFs) are a common, devastating, event in the life of a patient with Crohn's disease. ARFs occur in up to 50% of patients with Crohn's disease. Treatment begins with surgical drainage of the initial abscess, followed by antibiotic therapy, then anti-inflammatory medications. If medical therapy fails to close the fistula tract, surgical intervention is often pursued. Surgery incurs risk of incontinence because of sphincter injury. Increasingly, the role of cell-based therapy is being investigated in ARFs...
November 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28945013/pro-regenerative-hydrogel-restores-scarless-skin-during-cutaneous-wound-healing
#14
Guoming Sun
The transformation of fibrotic healing process to regenerative one has great potential to fully restore wounded skin. The M2 macrophage phenotype promotes constructive tissue remodeling and instructs tissue repair in a regenerative manner. It is hypothesized that hydrogels that can establish robustness of endogenous cells to regulate M2 phenotype will promote constructive dermal remodeling. Toward this end, a series of dextran-based bioabsorbable hydrogels are developed and self-crosslinkable dextran-isocyanatoethyl methacrylate-ethylamine (DexIEME) is identified as the potential scaffold...
December 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28918876/evaluation-of-potential-substrates-for-restenosis-and-thrombosis-in-overlapped-versus-edge-to-edge-juxtaposed-bioabsorbable-scaffolds-insights-from-a-computed-fluid-dynamic-study
#15
Gianluca Rigatelli, Marco Zuin, Fabio Dell'Avvocata, Paolo Cardaioli, Dobrin Vassiliev, Miroslaw Ferenc, Nguyen Tuan Nghia, Thach Nguyen, Nicholas Foin
BACKGROUND/PURPOSE: Multiple BRSs and specifically the Absorb scaffold (BVS) (Abbott Vascular, Santa Clara, CA USA) have been often used to treat long diffuse coronary artery lesions. We evaluate by a computational fluid dynamic(CFD) study the impact on the intravascular fluid rheology on multiple bioabsorbable scaffolds (BRS) by standard overlapping versus edge-to-edge technique. METHODS/MATERIALS: We simulated the treatment of a real long significant coronary lesion (>70% luminal narrowing) involving the left anterior descending artery (LAD) treated with a standard or edge-to-edge technique, respectively...
August 17, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28893770/serial-5-year-evaluation-of-side-branches-jailed-by-bioresorbable-vascular-scaffolds-using-3-dimensional-optical-coherence-tomography-insights-from-the-absorb-cohort-b-trial-a-clinical-evaluation-of-the-bioabsorbable-everolimus-eluting-coronary-stent-system
#16
Yoshinobu Onuma, Maik J Grundeken, Shimpei Nakatani, Taku Asano, Yohei Sotomi, Nicolas Foin, Jaryl Ng, Takayuki Okamura, Joanna J Wykrzykowska, Robbert J de Winter, Robert-Jan van Geuns, Jacques Koolen, Evald Christiansen, Robert Whitbourn, Dougal McClean, Pieter Smits, Stephan Windecker, John A Ormiston, Patrick W Serruys
BACKGROUND: The long-term fate of Absorb bioresorbable vascular scaffold (Abbott Vascular, Santa Clara, CA) struts jailing side branch ostia has not been clarified. We therefore evaluate serially (post-procedure and at 6 months, 1, 2, 3, and 5 years) the appearance and fate of jailed Absorb bioresorbable vascular scaffold struts. METHODS AND RESULTS: We performed 3-dimensional optical coherence tomographic analysis of the ABSORB Cohort B trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) up to 5 years using a novel, validated cut-plane analysis method...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28801538/comparison-of-acute-thrombogenicity-for-metallic-and-polymeric-bioabsorbable-scaffolds-magmaris-versus-absorb-in-a-porcine-arteriovenous-shunt-model
#17
Ron Waksman, Michael J Lipinski, Eduardo Acampado, Qi Cheng, Lila Adams, Sho Torii, Jiaxiang Gai, Rebecca Torguson, David M Hellinga, Peter C Westman, Michael Joner, Philine Zumstein, Frank D Kolodgie, Renu Virmani
BACKGROUND: A comparison in acute thrombogenicity between the Magmaris sirolimus-eluting bioabsorbable magnesium scaffold and the Absorb bioresorbable vascular scaffold has not been performed. This study assessed acute thrombogenicity of Magmaris compared with Absorb and the Orsiro hybrid drug-eluting stent in a porcine arteriovenous shunt model. METHODS AND RESULTS: An ex vivo porcine carotid jugular arteriovenous shunt was established and connected to SYLGARD tubing containing the Magmaris, Absorb, and Orsiro scaffolds/stents and allowed to run in the shunt for a maximum of 1 hour...
August 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28773109/thermomechanical-properties-of-polylactic-acid-graphene-composites-a-state-of-the-art-review-for-biomedical-applications
#18
REVIEW
Ilker S Bayer
Due to its biodegradable and bioabsorbable characteristics polylactic acid (PLA) has attracted considerable attention for numerous biomedical applications. Moreover, a number of tissue engineering problems for function restoration of impaired tissues have been addressed by using PLA and its copolymers due to their biocompatibility and distinctive mechanical properties. Recent studies on various stereocomplex formation between enantiomeric PLA, poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA) indicated that stereocomplexation enhances the mechanical properties as well as the thermal- and hydrolysis-resistance of PLA polymers...
July 4, 2017: Materials
https://www.readbyqxmd.com/read/28707322/development-and-validation-of-a-risk-model-for-long-term-mortality-after-percutaneous-coronary-intervention-the-idea-bio-study
#19
Nick van Boven, Ron T van Domburg, Isabella Kardys, Victor A Umans, K Martijn Akkerhuis, Mattie J Lenzen, Marco Valgimigli, Joost Daemen, Felix Zijlstra, Eric Boersma, Robert-Jan van Geuns
OBJECTIVES: We aimed to develop a model to predict long-term mortality after percutaneous coronary intervention (PCI), to aid in selecting patients with sufficient life expectancy to benefit from bioabsorbable scaffolds. BACKGROUND: Clinical trials are currently designed to demonstrate superiority of bioabsorbable scaffolds over metal devices up to 5 years after implantation. METHODS: From 2000 to 2011, 19.532 consecutive patients underwent PCI in a tertiary referral hospital...
July 14, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28644215/treatment-of-coronary-stent-restenosis-with-drug-eluting-bioabsorbable-magnesium-scaffolds
#20
Fernando Alfonso, Javier Cuesta, Marcos García-Guimaraes, Teresa Bastante, Ramón Maruri, Fernando Rivero
No abstract text is available yet for this article.
November 2017: Coronary Artery Disease
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