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Bioabsorbable scaffolds

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https://www.readbyqxmd.com/read/28707322/development-and-validation-of-a-risk-model-for-long-term-mortality-after-percutaneous-coronary-intervention-the-idea-bio-study
#1
Nick van Boven, Ron T van Domburg, Isabella Kardys, Victor A Umans, K Martijn Akkerhuis, Mattie J Lenzen, Marco Valgimigli, Joost Daemen, Felix Zijlstra, Eric Boersma, Robert-Jan van Geuns
OBJECTIVES: We aimed to develop a model to predict long-term mortality after percutaneous coronary intervention (PCI), to aid in selecting patients with sufficient life expectancy to benefit from bioabsorbable scaffolds. BACKGROUND: Clinical trials are currently designed to demonstrate superiority of bioabsorbable scaffolds over metal devices up to 5 years after implantation. METHODS: From 2000 to 2011, 19.532 consecutive patients underwent PCI in a tertiary referral hospital...
July 14, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28644215/treatment-of-coronary-stent-restenosis-with-drug-eluting-bioabsorbable-magnesium-scaffolds
#2
Fernando Alfonso, Javier Cuesta, Marcos García-Guimaraes, Teresa Bastante, Ramón Maruri, Fernando Rivero
No abstract text is available yet for this article.
June 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28601882/bioabsorbable-scaffolds-can-the-problems-of-dissolution-be-overcome
#3
Mary C Shields, Sheldon Goldberg
No abstract text is available yet for this article.
June 10, 2017: Cardiology
https://www.readbyqxmd.com/read/28576627/comparison-of-everolimus-and-biolimus-eluting-coronary-stents-with-everolimus-eluting-bioresorbable-vascular-scaffolds-two-year-clinical-outcomes-of-the-everbio-ii-trial
#4
Diego Arroyo, Gregoire Gendre, Sara Schukraft, Zacharenia Kallinikou, Olivier Müller, Gérard Baeriswyl, Jean-Christophe Stauffer, Jean-Jacques Goy, Mario Togni, Stéphane Cook, Serban Puricel
BACKGROUND: Data from randomized controlled trials have shown that the ABSORB BVS is non-inferior to Cobalt Chromium everolimus-eluting stents at 2years. METHODS & RESULTS: The EVERBIO II trial (Comparison of Everolimus- and Biolimus-Eluting Coronary Stents with Everolimus-Eluting Bioresorbable Vascular Scaffold) is a single-center, assessor-blind, randomized controlled trial enrolling 240 patients with an allocation ration of 1:1:1 conducted at University and Hospital Fribourg, Switzerland...
May 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28548695/development-of-a-novel-bioabsorbable-implant-that-is-substituted-by-adipose-tissue-in-vivo
#5
Shuichi Ogino, Naoki Morimoto, Michiharu Sakamoto, Chizuru Jinno, Katsuhiro Yoshikawa, Tatsuki Enoshiri, Yuki Sakamoto, Tsuguyoshi Taira, Shigehiko Suzuki
Recently, adipose tissue has been regenerated by combining scaffolds, growth factors, and/or adipose tissue-derived stromal cells (ASCs). However, the safety of growth factors and ASCs has not been confirmed in cancer patients. We reported the regeneration of adipose tissue in the internal space of a polypropylene mesh containing a collagen sponge (CS), without using any growth factors or cells. We herein explored the formation of adipose tissue, using the bioabsorbable implant containing CS, in rats. We prepared the implants without and with CS, using threads of either poly l-lactide-co-ε-caprolactone [P(LA/CL)] or poly-l-lactic acid (PLLA), and measured their strengths...
May 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28546035/hybrid-metal-scaffold-jacket-versus-full-metal-jackets-in-left-anterior-descending-coronary-artery-diffuse-disease-differences-in-radiation-exposure-and-fluoroscopic-procedural-times
#6
Gianluca Rigatelli, Marco Zuin, Jacopo Frigato, Fabio Dell'Avvocata, Federico Ronco, Alberto Mazza, Laura Oliva, Dario Adami, Emiliano Bedendo, Panin Stefano
BACKGROUND/PURPOSE: Bioabsorbable vascular scaffolds (BVS) are made from a radiolucent material. Their multiple implantations on a single long diffused segment requires a specific technique with imaging magnification, which could cause an increase in dose delivered during percutaneous coronary intervention (PCI) procedure. We aimed to identify differences in radiation dose, fluoroscopy and procedural times in Hybrid DES+ multiple BVS (Absorb, Abbott Inc., USA) implantation (hybrid metal/scaffold jacket) versus multiple III generation Drug-eluting stents (DES) (full-metal jacket) in patients with long and diffuse coronary artery disease of the left anterior descending (LAD) coronary artery...
May 18, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28523173/thrombotic-responses-to-coronary-stents-bioresorbable-scaffolds-and-the-kounis-hypersensitivity-associated-acute-thrombotic-syndrome
#7
REVIEW
Nicholas G Kounis, Ioanna Koniari, Anastasios Roumeliotis, Grigorios Tsigas, George Soufras, Nicholas Grapsas, Periklis Davlouros, George Hahalis
Percutaneous transluminal coronary angioplasty with coronary stent implantation is a life-saving medical procedure that has become, nowadays, the most frequent performed therapeutic procedure in medicine. Plain balloon angioplasty, bare metal stents, first and second generation drug-eluting stents, bioresorbable and bioabsorbable scaffolds have offered diachronically a great advance against coronary artery disease and have enriched our medical armamentarium. Stented areas constitute vulnerable sites for endothelial damage, endothelial dysfunction, flow turbulence, hemorheologic changes, platelet dysfunction, coagulation changes and fibrinolytic disturbances...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28504228/italy-coronary-and-structural-heart-interventions-from-2010-to-2015
#8
Sergio Berti, Ferdinando Varbella, Alfredo Marchese, Luigi Emilio Pastormerlo, Giuseppe Musumeci
The aim of this report is to analyse trends in Italian cathlab activity between 2010 and 2015. Data were obtained from the national database of the Italian Society of Interventional Cardiology (GISE), which includes 97% of Italian cardiac catheterisation laboratories. The number of percutaneous coronary interventions (PCI) has remained relatively stable in the past five years. We have observed a significant increase in the number of primary PCI (pPCI) from 471.5 to 557.5 per million inhabitants with a consequent reduction of rescue primary PCI/fibrinolysis...
May 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28504224/denmark-coronary-and-structural-heart-interventions-from-2010-to-2015
#9
Hans-Henrik Tilsted, Ole Ahlehoff, Christian J Terkelsen, Frants Pedersen, Cengiz Özcan, Troels H Jørgensen, Jens E Nielsen-Kudsk, Jan Ravkilde, Henrik Nissen, Sune A Pedersen, Ole Havndrup, Jens F Lassen
Interventional cardiology in Denmark has been carried out since the mid 1980s. Interventional cardiology is only performed at a few high-volume centres. Healthcare coverage is universal and is essentially free of charge. Hospitals are mostly publicly owned and financed by fixed budgets and, in part, an activity-based funding system. Approximately 30,000 coronary angiographies (CAG), 10,000 percutaneous coronary interventions (PCIs) of which approximately 25% are primary PCIs, and 500 transcatheter aortic valve implantations (TAVIs) are carried out each year...
May 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28471065/novel-ultrahigh-molecular-weight-amorphous-plla-bioresorbable-coronary-scaffold-upsized-up-to-0-8-mm-beyond-nominal-diameter-an-oct-and-histopathology-study-in-porcine-coronary-artery-model
#10
Pawel Gasior, Yanping Cheng, Edward A Estrada, Jenn McGregor, Kamal Ramzipoor, Chang Lee, Gerard B Conditt, Serge D Rousselle, Juan F Granada, Grzegorz L Kaluza
OBJECTIVES: The aim of the study was to evaluate the biomechanical properties and healing pattern of novel sirolimus-eluting, ultrahigh molecular weight amorphous poly-L-lactic acid bioresorbable scaffolds (S-BRS) that have been postdilated by 0.55 and 0.8 mm beyond the nominal diameters within the pressure-diameter compliance chart range. BACKGROUND: Due to the inherent limitations of bioabsorbable polymeric materials, overexpansion/upsizing may be very limited for some BRS such as the benchmark Absorb BVS...
May 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28275942/bioresorbable-polymers-and-stent-devices
#11
REVIEW
Payam Dehghani
Percutaneous coronary interventions will never become obsolete, as evolution is inherent to interventional cardiology. Current drug-eluting platforms have appreciably improved their safety and efficacy profiles in different clinical settings compared to first-generation devices such that it is difficult to consider other alternatives. However, there is definite biological plausibility to consider devices with bioabsorbable polymers and/or scaffolds. It is also an undeniable fact that many patients, based on variety of belief systems, would prefer not to have a permanently implanted device...
February 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28220461/new-generation-coronary-stents-current-data-and-future-directions
#12
REVIEW
Ankur Kalra, Hasan Rehman, Sahil Khera, Braghadheeswar Thyagarajan, Deepak L Bhatt, Neal S Kleiman, Robert W Yeh
PURPOSE OF REVIEW: Drug-eluting stents are the mainstay in the treatment of coronary artery disease using percutaneous coronary intervention. Innovations developed to overcome the limitations of prior generations of stents include biodegradable polymer stents, drug-eluting stents without a polymer, and bioabsorbable scaffolds. Our review briefly discusses the clinical profiles of first- and second-generation coronary stents, and provides an up-to-date overview of design, technology, and clinical safety and efficacy profiles of newer generation coronary stents discussing the relevant clinical trials in this rapidly evolving area of interventional cardiology...
March 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28183636/improved-tympanic-membrane-regeneration-after-myringoplastic-surgery-using-an-artificial-biograft
#13
A P S Immich, P C Pennacchi, A F Naves, S L Felisbino, R L Boemo, S S Maria-Engler, L H Catalani
Tympanic membrane perforations are due to common otologic problems. The current treatments to heal tympanic membrane perforation, such as myringoplasty, have some disadvantages, including the need for autologous grafting, which is rapidly absorbed by the organism before perforation recovery is complete. To improve the structural and functional tympanic membrane healing after surgery, we propose a new branch of artificial grafts. In this study, we report the development of artificial grafts using electrospun bioabsorbable polymers...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28160103/stents-biomechanics-biomaterials-and-insights-from-computational-modeling
#14
REVIEW
Georgia S Karanasiou, Michail I Papafaklis, Claire Conway, Lampros K Michalis, Rami Tzafriri, Elazer R Edelman, Dimitrios I Fotiadis
Coronary stents have revolutionized the treatment of coronary artery disease. Improvement in clinical outcomes requires detailed evaluation of the performance of stent biomechanics and the effectiveness as well as safety of biomaterials aiming at optimization of endovascular devices. Stents need to harmonize the hemodynamic environment and promote beneficial vessel healing processes with decreased thrombogenicity. Stent design variables and expansion properties are critical for vessel scaffolding. Drug-elution from stents, can help inhibit in-stent restenosis, but adds further complexity as drug release kinetics and coating formulations can dominate tissue responses...
February 3, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28017123/current-state-of-bioabsorbable-polymer-coated-drug-eluting-stents
#15
Akinapelli Absdhilash, Jack P Chen, Kristine Roy, Joseph Donnelly, Keith Dawkins, Barbara Huibregtse, Dongming Hou
Drug-eluting stents (DES) have been shown to significantly reduce clinical and angiographic restenosis compared to bare metal stents (BMS). The polymer coatings on DES elute antiproliferative drugs to inhibit intimal proliferation and prevent restenosis after stent implantation. Permanent polymers which do not degrade in vivo may increase the likelihood of stent-related delayed arterial healing or polymer hypersensitivity. In turn, these limitations may contribute to an increased risk of late clinical events...
December 22, 2016: Current Cardiology Reviews
https://www.readbyqxmd.com/read/27969760/tct-410-different-vascular-healing-process-between-bioabsorbable-polymer-coated-everolimus-eluting-stents-versus-bioresorbable-vascular-scaffolds-via-optical-coherence-tomography-and-coronary-angioscopy-early-results-from-endothelial-healing-assessment-with
#16
Wan Azman Wan Ahmad, Takaharu Nakayoshi, Ahmad Syadi Mahmood Zuhdi, Muhammad Dzafir Ismail, Yoshihiro Fukumoto, Takafumi Ueno
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27807948/procedural-resources-utilization-and-clinical-outcomes-with-bioresorbable-everolimus-eluting-scaffolds-and-pt-cr-everolimus-eluting-stent-with-resorbable-abluminal-polymer-in-clinical-practice-a-randomized-trial
#17
Jose M de la Torre Hernandez, Tamara Garcia Camarero, Dae-Hyun Lee, Fermin Sainz Laso, Gabriela Veiga Fernandez, Tania Pino, Silvia Rubio, Pablo Legarra, Jorge R Valdivia, Javier Zueco Gil
OBJECTIVES: We sought to compare the procedural implications of using bioresorbable everolimus-eluting scaffolds (BVS) and Pt-Cr everolimus-eluting stent with abluminal bioabsorbable polymer (Synergy). BACKGROUND: There are important differences in the respective platforms, which could impact on procedural performance, complications and outcomes. METHODS: A prospective, randomized single center study including consecutive patients in stable clinical condition and with lesions amenable to be treated with BVS according to predefined criteria...
November 3, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27692818/the-nidus-for-possible-thrombus%C3%A2-formation-insight-from-the-microenvironment-of-bioresorbable-vascular-scaffold
#18
Erhan Tenekecioglu, Eric K W Poon, Carlos Collet, Vikas Thondapu, Ryo Torii, Christos V Bourantas, Yaping Zeng, Yoshinobu Onuma, Andrew S H Ooi, Patrick W Serruys, Peter Barlis
No abstract text is available yet for this article.
October 24, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27629596/development-of-bioresorbable-hydrophilic-hydrophobic-electrospun-scaffolds-for-neural-tissue-engineering
#19
Luanda Chaves Lins, Florence Wianny, Sébastien Livi, Idalba Andreina Hidalgo, Colette Dehay, Jannick Duchet-Rumeau, Jean-François Gérard
In this study, electrospun fiber scaffolds based on biodegradable and bioabsorbable polymers and showing a similar structure to that of the extracellular matrix (ECM) present in the neural tissues were prepared. The effects of electrospun-based scaffolds processed from poly(lactic acid) (PLA)/poly(lactide-b-ethylene glycol-b-lactide) block copolymer (PELA) and PLA/polyethylene glycol (PEG) (50:50 by wt) blends on the morphology, wettability, and mechanical properties, as well as on neural stem cell (NSC) behavior, were investigated...
October 10, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27531492/optical-coherence-tomography-imaging-after-successful-percutaneous-coronary-intervention-treatment-of-coronary-perforation-following-bioabsorbable-vascular-scaffold-implantation-consecutive-ping-pong-and-child-in-mother-techniques
#20
LETTER
Carlos Cortés, Ignacio J Amat-Santos, Milosz Jaguszewski, Paol Rojas, L Renier Gonçalves, Juan Luis Gutiérrez-Chico, J Alberto San Román
No abstract text is available yet for this article.
2016: Cardiology Journal
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