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Alcohol ingestion

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https://www.readbyqxmd.com/read/28632197/toxic-age-tage-theory-for-the-pathophysiology-of-the-onset-progression-of-nafld-and-ald
#1
REVIEW
Masayoshi Takeuchi, Jun-Ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi
Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are among the most common causes of chronic liver diseases in the westernized world. NAFLD and ALD are frequently accompanied by extrahepatic complications, including hepatocellular carcinoma and cardiovascular diseases, which have a negative impact on patient survival. The chronic ingestion of an excessive daily diet containing sugar/high-fructose corn syrup increases the level of the fructose/glucose metabolite, glyceraldehyde (GA), while the chronic consumption of an excessive number of alcoholic beverages increases the level of the alcohol metabolite, acetaldehyde (AA) in the liver...
June 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28632074/isopropyl-alcohol-swabs-as-a-preferred-substance-of-abuse
#2
Aditi Sharma, Jonathan D Morrow
The authors describe the treatment of a 36-year-old woman who presented with excessive consumption of antiseptic alcohol swabs. Her behavior was diagnosed as a severe substance use disorder with isopropyl alcohol as the primary drug of choice. Diagnostic and treatment challenges involved in the case are discussed in detail, with particular focus on the differential diagnosis for this unusual presentation, including obsessive compulsive disorder, pica, and intentional self-injurious behavior. A brief review of the literature on non-ethanol ingestion for the purposes of intoxication is included, as well as clinical information about the potential dangers posed by isopropyl alcohol consumption...
February 26, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28617958/alcohol-consumption-decreases-oxytocin-neurons-in-the-anterior-paraventricular-nucleus-of-the-hypothalamus-in-prairie-voles
#3
J R Stevenson, K A Young, A E Bohidar, L M Francomacaro, T R Fasold, J M Buirkle, J R Ndem, S C Christian
BACKGROUND: Alcohol use disorders are associated with dysfunctional social relationships and stress responses. The neuropeptides oxytocin (OT) and vasopressin (AVP) are known to orchestrate or mediate many aspects of social behavior, stress responses, and ingestive behaviors. Because of the overlap between the effects of alcohol and the roles of oxytocin and vasopressin, we sought to determine if alcohol consumption altered expression of OT and AVP in the paraventricular nucleus of the hypothalamus (PVN), one of the key sites for OT and AVP synthesis...
June 15, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28598064/emphysematous-gastritis-with-air-in-portal-venous-system
#4
Omesh Goyal, Ajesh Bansal, Prerna Goyal
Emphysematous gastritis is a rare but severe form of phlegmonous gastritis caused by gastric mucosal disruption and infection of stomach wall by gas-forming bacteria. Ingestion of corrosive substances is the most common predisposing factor, followed by alcohol abuse, abdominal surgery, diabetes and immunosuppression. Patients usually present with abdominal pain, vomiting, diarrhea, constipation and/or gastro-intestinal hemorrhage. Characteristic radiological findings include presence of gas in the gastric wall...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28594397/establishment-of-a-quick-and-highly-accurate-breath-test-for-aldh2-genotyping
#5
Ikuo Aoyama, Shinya Ohashi, Yusuke Amanuma, Kenshiro Hirohashi, Ayaka Mizumoto, Makiko Funakoshi, Mihoko Tsurumaki, Yukie Nakai, Katsuyuki Tanaka, Mariko Hanada, Aki Uesaka, Tsutomu Chiba, Manabu Muto
OBJECTIVES: Acetaldehyde, the first metabolite of ethanol, is a definite carcinogen for the esophagus, head, and neck; and aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that catalyzes the metabolism of acetaldehyde. The ALDH2 genotype exists as ALDH2*1/*1 (active ALDH2), ALDH2*1/*2 (heterozygous inactive ALDH2), and ALDH2*2/*2 (homozygous inactive ALDH2). Many epidemiological studies have reported that ALDH2*2 carriers are at high risk for esophageal or head and neck squamous cell carcinomas by habitual drinking...
June 8, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28591763/non-linear-formation-of-etg-and-faees-after-controlled-administration-of-low-to-moderate-doses-of-ethanol
#6
Clara Pérez-Mañá, Magí Farré, Antoni Pastor, Francina Fonseca, Marta Torrens, Esther Menoyo, Mitona Pujadas, Silvia Frias, Klaus Langohr, Rafael de la Torre
Aims: Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) are non-oxidative metabolites of alcohol that can be detected in conventional and non-conventional biological matrices for longer periods than alcohol. The aim was to describe the time courses of both biomarkers after ingestion of acute low-moderate doses of ethanol. Methods: The study design was double-blind, randomized, crossover and controlled with placebo. Participants were distributed in three different cohorts: (a) Cohort-1: two doses of 18 and 30 g of ethanol and placebo were administered to 12 subjects; (b) Cohort-2: two doses of 6 and 12 g of ethanol and placebo were administered to six subjects and (c) Cohort-3: two doses of 24 and 42 g of ethanol and placebo were administered to six subjects...
June 7, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28585211/non-alcoholic-fatty-liver-disease
#7
Atilla Engin
Non-alcoholic fatty liver disease (NAFLD) is in parallel with the obesity epidemic and it is the most common cause of liver diseases. The development of hepatic steatosis in majority of patients is linked to dietary fat ingestion. NAFLD is characterized by excess accumulation of triglyceride in the hepatocyte due to both increased inflow of free fatty acids and de novo hepatic lipogenesis. Insulin resistance with the deficiency of insulin receptor substrate-2 (IRS-2)-associated phosphatidylinositol 3-kinase (PI3K) activity causes an increase in intracellular fatty acid-derived metabolites such as diacylglycerol, fatty acyl CoA or ceramides...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551931/-acute-alcohol-intoxication-in-an-eight-weeks-old-infant
#8
Tal Frenkel Rutenberg, Michael Benacun
Alcohol intoxication in infants is a life-threatening condition which requires early diagnosis and treatment. It may lead to multi-system injury, including mental deterioration, respiratory depression, cardiac arrhythmia, metabolic disorders and hypothermia. We present the case of an eight weeks old female infant who was admitted to the pediatric emergency department after ingesting 40 ml of vodka with her baby formula. She was initially apathetic, with blood alcohol levels of 149 mg/dl, yet fully recovered after a short period of time...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551601/sequential-episodes-of-ethylene-glycol-poisoning-in-the-same-person
#9
Jaya Prakash Sugunaraj, Lokendra Kumar Thakur, Kunal Kishor Jha, Ion Dan Bucaloiu
Ethylene glycol is a common alcohol found in many household products such as household hard surface cleaner, paints, varnish, auto glass cleaner and antifreeze. While extremely toxic and often fatal on ingestion, few cases with early presentation by the patient have resulted in death; thus, rapid diagnosis is paramount to effectively treating ethylene glycol poisoning. In this study, we compare two sequential cases of ethylene glycol poisoning in a single individual, which resulted in strikingly different outcomes...
May 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28543549/review-article-recent-insights-into-clinical-decision-making-in-severe-alcoholic-hepatitis
#10
REVIEW
P D J Dunne, E H Forrest
BACKGROUND: Alcoholic hepatitis is a severe acute manifestation of alcoholic liver disease with a high mortality. Management of patients with this condition has been a matter of controversy for many years; however, recent clinical studies have sought to improve the clinical approach to these patients. AIM: To use these recent studies in order to guide clinical management. METHODS: A MeSH search of Medline was performed to specifically identify recent studies which influenced clinical diagnosis, assessment and management of alcoholic hepatitis...
May 21, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28543099/evidence-of-altered-mitochondrial-protein-expression-after-chronic-ethanol-consumption-in-the-aged-estrogen-deficient-female-rat-heart
#11
Alexandra M Garvin, J L Miller-Lee, D R Sharda, G M Kanski, J C Hunter, Donna H Korzick
BACKGROUND: Estrogen loss has been implicated to increase the risk of alcoholic cardiomyopathy in post-menopausal women. The purpose of this study was to identify novel mitochondrial protein targets for the treatment of alcoholic cardiomyopathy in aged women using a state-of-the-art proteomics approach. We hypothesized that chronic ethanol (EtOH) ingestion exacerbates maladaptive mitochondrial protein expression in the aged female heart METHODS: Adult (3 mo) and aged (18 mo) F344 ovary-intact or ovariectomized (OVX) rats were randomly assigned an EtOH or control Lieber-DeCarli 'all liquid' diet for 20 wks...
May 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28522597/alcohol-aging-and-innate-immunity
#12
REVIEW
Lisbeth A Boule, Elizabeth J Kovacs
The global population is aging: in 2010, 8% of the population was older than 65 y, and that is expected to double to 16% by 2050. With advanced age comes a heightened prevalence of chronic diseases. Moreover, elderly humans fair worse after acute diseases, namely infection, leading to higher rates of infection-mediated mortality. Advanced age alters many aspects of both the innate and adaptive immune systems, leading to impaired responses to primary infection and poor development of immunologic memory. An often overlooked, yet increasingly common, behavior in older individuals is alcohol consumption...
May 18, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28492119/paraquat-poisoning-acute-lung-injury-a-missed-diagnosis
#13
Sipho D Ntshalintshali, Thandekile C Manzini
Paraquat is a herbicide of great toxicological importance because it is associated with high mortality rates, mainly due to respiratory failure. We report the case of a 28-year-old man admitted to the casualty department at Ngwelezana Hospital, Empangeni, KwaZulu-Natal, South Africa, with a history of vomiting and abdominal pain after ingestion of ~100 mL of an unknown substance, later identified as paraquat, together with an unknown amount of alcohol, in a suicide attempt. He developed respiratory distress associated with lung parenchymal infiltrates that required ventilatory support and later a spontaneous pneumothorax, and died in the intensive care unit...
April 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28489307/non-alcoholic-fatty-liver-nafl-and-advanced-fibrosis-in-the-elderly-results-from-a-community-based-polish-survey
#14
Marek Hartleb, Kamil Barański, Jan Zejda, Jerzy Chudek, Andrzej Więcek
INTRODUCTION & AIM: Development of non-alcoholic fatty liver (NAFL) is dependent on metabolic factors occurring at an increased frequency with advancing age. Until now, few studies have explored the prevalence of NAFL in aged populations. Our study aimed to determine the prevalence of NAFL and advanced fibrosis in the elderly population participating in a national survey of a community-based elderly cohort. METHODS: A total of 3003 participants (mean age 79.6 years, 46...
May 10, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28482932/do-pre-hospital-poisoning-deaths-differ-from-in-hospital-deaths-a-retrospective-analysis
#15
Lauri Koskela, Lasse Raatiniemi, Håkon Kvåle Bakke, Tero Ala-Kokko, Janne Liisanantti
BACKGROUND: Most fatal poisonings occur outside the hospital and the victims found dead. The purpose of this study was to determine the general pattern and patient demographics of fatal poisonings in Northern Finland. In particular, we wanted to analyze differences between pre-hospital and in-hospital deaths. METHODS: All fatal poisonings that occurred in Northern Finland in 2007-2011 were retrieved from the Cause of Death Registry provided by Statistics Finland...
May 8, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28467924/fgf21-is-a-sugar-induced-hormone-associated-with-sweet-intake-and-preference-in-humans
#16
Susanna Søberg, Camilla H Sandholt, Naja Z Jespersen, Ulla Toft, Anja L Madsen, Stephanie von Holstein-Rathlou, Trisha J Grevengoed, Karl B Christensen, Wender L P Bredie, Matthew J Potthoff, Thomas P J Solomon, Camilla Scheele, Allan Linneberg, Torben Jørgensen, Oluf Pedersen, Torben Hansen, Matthew P Gillum, Niels Grarup
The liking and selective ingestion of palatable foods-including sweets-is biologically controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and disease. The hepatokine fibroblast growth factor 21 (FGF21) reduces sweet consumption in rodents and primates, whereas knockout of Fgf21 increases sugar consumption in mice. To investigate the relevance of these findings in humans, we genotyped variants in the FGF21 locus in participants from the Danish Inter99 cohort (n = 6,514) and examined their relationship with a detailed range of food and ingestive behaviors...
May 2, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28462386/association-of-variants-of-arginine-vasopressin-and-arginine%C3%A2-vasopressin-receptor-1a-with-severe-acetaminophen%C3%A2-liver-injury
#17
Matthew Randesi, Orna Levran, Joel Correa da Rosa, Julia Hankins, Jody Rule, Mary Jeanne Kreek, William M Lee
BACKGROUND & AIMS: Acetaminophen-related acute liver injury and liver failure (ALF) result from ingestion of supratherapeutic quantities of this analgesic, frequently in association with other forms of substance abuse including alcohol, opioids, and cocaine. Thus, overdosing represents a unique high-risk behavior associated with other forms of drug use disorder. METHODS: We examined a series of 21 single nucleotide polymorphisms (SNPs) in 9 genes related to impulsivity and/or stress responsivity that may modify response to stress...
May 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28462133/effects-of-the-herb-mixture-dts20-on-oxidative-stress-and-plasma-alcoholic-metabolites-after-alcohol-consumption-in-healthy-young-men
#18
Yang Hee Hong
BACKGROUND: This study was designed to investigate the effect of a herbal mixture extract (DTS20) on the attenuation of oxidative stress and hangover after alcohol consumption in healthy volunteers. METHODS: DTS20 consists of Viscum album L. (40%), Lycium chinense L. (30%), Inonotus obliquus (20%), and Acanthopanax senticosus H. (10%). We recruited healthy, nonsmoking, adult men volunteers aged between 21 years and 30 years to participate in a crossover trial. Twenty participants received either one package of placebo with 200 mL water or DTS20 with 200 mL water...
December 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28459061/patients-admitted-to-three-spanish-intensive-care-units-for-poisoning-type-of-poisoning-mortality-and-functioning-of-prognostic-scores-commonly-used
#19
María Esther Banderas-Bravo, Maria Dolores Arias-Verdú, Ines Macías-Guarasa, Eduardo Aguilar-Alonso, Encarnación Castillo-Lorente, Lucia Pérez-Costillas, Raquel Gutierrez-Rodriguez, Guillermo Quesada-García, Ricardo Rivera-Fernández
Objectives. To evaluate the gravity and mortality of those patients admitted to the intensive care unit for poisoning. Also, the applicability and predicted capacity of prognostic scales most frequently used in ICU must be evaluated. Methods. Multicentre study between 2008 and 2013 on all patients admitted for poisoning. Results. The results are from 119 patients. The causes of poisoning were medication, 92 patients (77.3%), caustics, 11 (9.2%), and alcohol, 20 (16,8%). 78.3% attempted suicides. Mean age was 44...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28444711/are-we-justified-in-suggesting-change-to-caffeine-alcohol-and-carbonated-drink-intake-in-lower-urinary-tract-disease-report-from-the-ici-rs-2015
#20
REVIEW
Dudley Robinson, Ann Hanna-Mitchell, Angie Rantell, Gans Thiagamoorthy, Linda Cardozo
AIMS: There is increasing evidence that diet may have a significant role in the development of lower urinary tract symptoms. While fluid intake is known to affect lower urinary tract function the effects of alcohol, caffeine, carbonated drinks, and artificial sweeteners are less well understood and evidence from epidemiological studies is mixed and sometimes contradictory. The aim of this paper is to appraise the available evidence on the effect of caffeine, alcohol, and carbonated drinks on lower urinary tract function and dysfunction in addition to suggesting proposals for further research...
April 2017: Neurourology and Urodynamics
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