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https://www.readbyqxmd.com/read/27919738/long-term-ethanol-self-administration-induces-%C3%AE-fosb-in-male-and-female-adolescent-but-not-in-adult-wistar-rats
#1
Aranza Wille-Bille, Soledad de Olmos, Leonardo Marengo, Florencia Chiner, Ricardo Marcos Pautassi
Early-onset ethanol consumption predicts later development of alcohol use disorders. Age-related differences in reactivity to ethanol's effects may underlie this effect. Adolescent rats are more sensitive and less sensitive than adults to the appetitive and aversive behavioral effects of ethanol, respectively, and more sensitive to the neurotoxic effects of experimenter-administered binge doses of ethanol. However, less is known about age-related differences in the neural consequences of self-administered ethanol...
December 2, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27878202/presence-of-orally-administered-rice-bran-oil-%C3%AE-oryzanol-in-its-intact-form-in-mouse-plasma
#2
Eri Kobayashi, Junya Ito, Shunji Kato, Kazue Sawada, Midori Matsuki, Hiroyuki Hashimoto, Teruo Miyazawa, Kiyotaka Nakagawa
Although the beneficial effects (e.g., lipid-lowering activity) of γ-oryzanol (OZ), a mixture of ferulic acid esters of plant sterols and triterpene alcohols, have been extensively investigated, few studies have evaluated the absorption and metabolism of OZ. Moreover, it is unclear whether OZ, once ingested, is directly absorbed by the intestine into the bloodstream at a sufficient level to exhibit activity. Here, we prepared OZ concentrate from purified rice bran oil (Rice Oil OZ), determined the concentration of OZ in the preparation (cycloartenyl ferulate equivalent concentration; 52...
November 23, 2016: Food & Function
https://www.readbyqxmd.com/read/27876672/is-there-a-human-health-risk-associated-with-indirect-exposure-to-perfluorinated-carboxylates-pfcas
#3
Amy A Rand, Scott A Mabury
The production and widespread use of poly- and perfluorinated alkyl substances (PFAS) has led to their presence in environment, wildlife, and humans. Particularly, the perfluorinated carboxylates (PFCAs) are pervasive throughout the world and have been found at ng/mL concentrations in human blood. PFCAs, especially those having longer carbon chain lengths (≥C6), are associated with developmental and hormonal effects, immunotoxicity, and promote tumor growth in rodents through their role as PPARα agonists...
November 19, 2016: Toxicology
https://www.readbyqxmd.com/read/27872968/new-functions-and-potential-applications-of-amino-acids
#4
Hisayuki Uneyama, Hisamine Kobayashi, Naoto Tonouchi
Currently, several types of amino acids are being produced and used worldwide. Nevertheless, several new functions of amino acids have been recently discovered that could result in other applications. For example, oral stimulation by glutamate triggers the cephalic phase response to prepare for food digestion. Further, the stomach and intestines have specific glutamate-recognizing systems in their epithelial mucosa. Regarding clinical applications, addition of monosodium glutamate to the medicinal diet has been shown to markedly enhance gastric secretion in a vagus-dependent manner...
November 22, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27861506/chronic-alcohol-ingestion-delays-t-cell-activation-and-effector-function-in-sepsis
#5
Lindsay M Margoles, Rohit Mittal, Nathan J Klingensmith, John D Lyons, Zhe Liang, Mara A Serbanescu, Maylene E Wagener, Craig M Coopersmith, Mandy L Ford
Sepsis is the leading cause of death in intensive care units in the US, and it is known that chronic alcohol use is associated with higher incidence of sepsis, longer ICU stays, and higher mortality from sepsis. Both sepsis and chronic alcohol use are associated with immune deficits such as decreased lymphocyte numbers, impaired innate immunity, delayed-type hypersensitivity reactions, and susceptibility to infections; however, understanding of specific pathways of interaction or synergy between these two states of immune dysregulation is lacking...
2016: PloS One
https://www.readbyqxmd.com/read/27852275/social-inequalities-in-health-behaviors-among-brazilian-adults-national-health-survey-2013
#6
Marilisa Berti de Azevedo Barros, Margareth Guimarães Lima, Lhais de Paula Barbosa Medina, Celia Landman Szwarcwald, Deborah Carvalho Malta
BACKGROUND: Considering the high socioeconomic inequalities prevailing in Brazil and lifestyle as a strong determinant of morbidity and premature mortality, our purpose was to evaluate the degree of socioeconomic disparities in the prevalence of health behaviors among Brazilian adult population using data from the 2013 Brazilian National Health Survey. METHOD: Based on a sample of 49,025 individuals aged 20 to 59 years, we estimated the prevalence of several health behaviors and a score of unhealthy behaviors according to gender, education, race/color and possession of private health insurance...
November 17, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27827799/amitraz-poisoning-an-unusual-cause-of-respiratory-and-peripheral-circulatory-failure
#7
Ishwar Agrawal, Sohaib Ahmad, Manoj Kumar, Mohamad Akram
We report a case of respiratory failure with unconsciousness in an adult occurring within 1 h of ingestion of a pesticide, amitraz, along with alcohol with a suicidal intent. Although commonly available and potentially fatal, this compound is not usually used as a suicidal agent.
November 8, 2016: Tropical Doctor
https://www.readbyqxmd.com/read/27827004/initial-experience-with-hand-assisted-laparoscopic-donor-nephrectomy-a-single-centre-experience-over-5-years
#8
Majken Højrup Wiborg, Anja Toft, Henrik Jahn, Lars Ulrich Hansen, Lars Lund
OBJECTIVE: The objective of this study was to evaluate outcome after hand-assisted live donor nephrectomy with a retroperitoneal approach during a 5 year period. MATERIALS AND METHODS: All donor nephrectomies at Odense University Hospital, Denmark, from January 2008 to December 2012 were identified retrospectively, and the medical records were examined. RESULTS: In total, 108 patients were enrolled: 68 females, with a median age of 50 years (range 24-68 years), and 40 males, with a median age of 51 years (32-70 years)...
November 9, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27817895/estimation-of-human-exposure-to-halogenated-flame-retardants-through-dermal-adsorption-by-skin-wipe
#9
Xiaotu Liu, Gang Yu, Zhiguo Cao, Bin Wang, Jun Huang, Shubo Deng, Yujue Wang, Hongbo Shen, Xue Peng
This study was undertaken to determine levels of halogenated flame retardants (HFRs) on skin surface to provide preliminary exposure estimates from dermal absorption. Skin wipes of palms, back-of-hands, and forearms were collected from 30 participants by using gauze pads soaked in isopropyl alcohol. Eight polybrominated diphenyl ethers (PBDEs), two novel brominated FRs, and two Dechlorane Plus (DPs) isomers were determined. BDE209, Decabromodiphenylethane (DBDPE), and 1, 2-Bis (2, 4, 6-tribromophenoxy) ethane (BTBPE) were most frequently detected...
November 3, 2016: Chemosphere
https://www.readbyqxmd.com/read/27807447/endoscopic-management-of-foreign-bodies-in-the-gastrointestinal-tract-a-review-of-the-literature
#10
REVIEW
Mikhael Bekkerman, Amit H Sachdev, Javier Andrade, Yitzhak Twersky, Shahzad Iqbal
Foreign body ingestion is a common diagnosis that presents in emergency departments throughout the world. Distinct foreign bodies predispose to particular locations of impaction in the gastrointestinal tract, commonly meat boluses in the esophagus above a preexisting esophageal stricture or ring in adults and coins in children. Several other groups are at high risk of foreign body impaction, mentally handicapped individuals or those with psychiatric illness, abusers of drugs or alcohol, and the geriatric population...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27799068/recurrent-purpura-due-to-alcohol-related-schamberg-s-disease-and-its-association-with-serum-immunoglobulins-a-longitudinal-observation-of-a-heavy-drinker
#11
Udo Bonnet, Claudia Selle, Katrin Isbruch, Katrin Isbruch
BACKGROUND: It is unusual for purpura to emerge as a result of drinking alcohol. Such a peculiarity was observed in a 55-year-old man with a 30-year history of heavy alcohol use. CASE PRESENTATION: The Caucasian patient was studied for 11 years during several detoxification treatments. During the last 2 years of that period, purpuric rashes were newly observed. The asymptomatic purpura was limited to both lower limbs, self-limiting with abstinence, and reoccurring swiftly with alcohol relapse...
October 31, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27795829/binge-eating-sociodemographic-and-lifestyle-factors-in-participants-of-the-elsa-brazil
#12
Thamyres Souza da Silva, Maria Del Carmen Bisi Molina, Maria Angélica Antunes Nunes, Carolina Perim de Faria, Nagela Valadão Cade
BACKGROUND: This study investigates the relationship between recurrent binge eating episodes and nutritional and food profiles and lifestyle in the Brazilian Longitudinal Study of Adult Health (Estudo Longitudinal da Saúde do Adulto - ELSA-Brazil) cohort. RESULTS: Recurrent binge eating episodes were associated with obesity (OR 5.188; confidence interval [CI] 4.051-6.645), overweight (OR 2.534; CI 1.980-3.243), female sex (OR 1.918; CI 1.573-2.338), age between 34 and 54 years old (OR 1...
2016: Journal of Eating Disorders
https://www.readbyqxmd.com/read/27790525/prevalence-and-predictors-of-alcohol-consumption-during-pregnancy-in-south-eastern-nigeria
#13
Chidinma Ifechi Onwuka, Emmanuel Onyebuchi Ugwu, Cyril Chukwudi Dim, Ifeanyi Emmanuel Menuba, Emeka Ifeanyi Iloghalu, Chidozie Ifechi Onwuka
INTRODUCTION: Alcohol consumption during pregnancy is a major public health problem because of the enormous deleterious effects on a developing fetus. Sub-Saharan Africa (SSA) is among the highest per capita rates of alcohol consumption in the world, thus suggesting a high burden of Fetal Alcohol Syndrome Disorder (FASD) in the sub-region. Despite this, there is limited data on alcohol exposed pregnancies for most SSA countries including Nigeria. AIM: To determine the prevalence and predictors of alcohol consumption during pregnancy in Enugu, South-Eastern Nigeria...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27788778/alcohol-and-lung-injury-and-immunity
#14
REVIEW
Samantha M Yeligar, Michael M Chen, Elizabeth J Kovacs, Joseph H Sisson, Ellen L Burnham, Lou Ann S Brown
Annually, excessive alcohol use accounts for more than $220 billion in economic costs and 80,000 deaths, making excessive alcohol use the third leading lifestyle-related cause of death in the US. Patients with an alcohol-use disorder (AUD) also have an increased susceptibility to respiratory pathogens and lung injury, including a 2-4-fold increased risk of acute respiratory distress syndrome (ARDS). This review investigates some of the potential mechanisms by which alcohol causes lung injury and impairs lung immunity...
September 2016: Alcohol
https://www.readbyqxmd.com/read/27788366/estimation-of-human-exposure-to-halogenated-flame-retardants-through-dermal-adsorption-by-skin-wipe
#15
Xiaotu Liu, Gang Yu, Zhiguo Cao, Bin Wang, Jun Huang, Shubo Deng, Yujue Wang, Hongbo Shen, Xue Peng
This study was undertaken to determine levels of halogenated flame retardants (HFRs) on skin surface to provide preliminary exposure estimates from dermal absorption. Skin wipes of palms, back-of-hands, and forearms were collected from 30 participants by using gauze pads soaked in isopropyl alcohol. Eight polybrominated diphenyl ethers (PBDEs), two novel brominated FRs, and two Dechlorane Plus (DPs) isomers were determined. BDE209, Decabromodiphenylethane (DBDPE), and 1, 2-Bis (2, 4, 6-tribromophenoxy) ethane (BTBPE) were most frequently detected...
October 24, 2016: Chemosphere
https://www.readbyqxmd.com/read/27784874/the-effect-of-consuming-small-volumes-of-beer-on-gastric-motility-and-the-involvement-of-gene-polymorphisms
#16
Tomoyuki Shibata, Hiromi Yamashita, Tomohiko Kawamura, Yasutaka Jodai, Takafumi Omori, Kazuya Sumi, Yuichiro Ichikawa, Masaaki Okubo, Takamitsu Ishizuka, Tomomitsu Tahara, Mitsuo Nagasaka, Yoshihito Nakagawa, Ichiro Hirata, Naoki Ohmiya, Makoto Nakao
The aim of this study was to investigate the effect of consuming small amounts of beer or a nonalcoholic beer taste beverage (non-beer) on gastric emptying and the polymorphisms in alcohol metabolism-related enzyme-encoding genes. Twenty male healthy volunteers were questioned regarding their alcohol consumption status, and body measurement was performed. The genetic polymorphisms in ADH1B (rs1229984, Arg47His) and ALDH2 (rs671 Glu487Lys) were analyzed. The subjects consumed 150 mL of beer or non-beer once per week, followed by the ingestion of 200 kcal of the test nutrient containing (13)C-acetate 15 min later, after which the subjects' exhalations were collected up to 120 min...
2016: Biomedical Research
https://www.readbyqxmd.com/read/27782737/resveratrol-alleviates-ethanol-induced-hormonal-and-metabolic-disturbances-in-the-rat
#17
K Szkudelska, M Deniziak, P Roś, K Gwóźdź, T Szkudelski
Resveratrol is a polyphenol found in different plant species and having numerous health-promoting properties in animals and humans. However, its protective action against deleterious effects of ethanol is poorly elucidated. In the present study, the influence of resveratrol (10 mg/kg/day) on some hormones and metabolic parameters was determined in rats ingesting 10% ethanol solution for two weeks. Blood levels of insulin, glucagon and adiponectin were affected by ethanol, however, resveratrol partially ameliorated these changes...
October 26, 2016: Physiological Research
https://www.readbyqxmd.com/read/27782289/unobtrusive-and-continuous-monitoring-of-alcohol-impaired-gait-using-smart-shoes
#18
Eunjeong Park, Sunghoon I Lee, Hyo Suk Nam, Jordan H Garst, Alex Huang, Andrew Campion, Monica Arnell, Nima Ghalehsariand, Sangsoo Park, Hyuk-Jae Chang, Daniel C Lu, Majid Sarrafzadeh
BACKGROUND: Alcohol ingestion influences sensory-motor function and the overall well-being of individuals. Detecting alcohol-induced impairments in gait in daily life necessitates a continuous and unobtrusive gait monitoring system. OBJECTIVES: This paper introduces the development and use of a non-intrusive monitoring system to detect changes in gait induced by alcohol intoxication. METHODS: The proposed system employed a pair of sensorized smart shoes that are equipped with pressure sensors on the insole...
October 26, 2016: Methods of Information in Medicine
https://www.readbyqxmd.com/read/27752492/carrot-juice-administration-decreases-liver-stearoyl-coa-desaturase-1-and-improves-docosahexaenoic-acid-levels-but-not-steatosis-in-high-fructose-diet-fed-weanling-wistar-rats
#19
Malleswarapu Mahesh, Munugala Bharathi, Mooli Raja Gopal Reddy, Manchiryala Sravan Kumar, Uday Kumar Putcha, Ayyalasomayajula Vajreswari, Shanmugam M Jeyakumar
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases associated with an altered lifestyle, besides genetic factors. The control and management of NAFLD mostly depend on lifestyle modifications, due to the lack of a specific therapeutic approach. In this context, we assessed the effect of carrot juice on the development of high fructose-induced hepatic steatosis. For this purpose, male weanling Wistar rats were divided into 4 groups, fed either a control (Con) or high fructose (HFr) diet of AIN93G composition, with or without carrot juice (CJ) for 8 weeks...
September 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/27752032/starvation-ketoacidosis-as-a-cause-of-unexplained-metabolic-acidosis-in-the-perioperative-period
#20
Monique Mostert, Anthony Bonavia
BACKGROUND Besides providing anesthesia for surgery, the anesthesiologist's role is to optimize the patient for surgery and for post-surgical recovery. This involves timely identification and treatment of medical comorbidities and abnormal laboratory values that could complicate the patient's perioperative course. There are several potential causes of anion and non-anion gap metabolic acidosis in surgical patients, most of which could profoundly affect a patient's surgical outcome. Thus, the presence of an acute acid-base disturbance requires a thorough workup, the results of which will influence the patient's anesthetic management...
October 18, 2016: American Journal of Case Reports
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