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https://www.readbyqxmd.com/read/28086768/probiotic-mixture-improves-fatty-liver-disease-by-virtue-of-its-action-on-lipid-profiles-leptin-and-inflammatory-biomarkers
#1
Hessah Mohammed Al-Muzafar, Kamal Adel Amin
BACKGROUND: A high fat diet has an essential role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). This condition is characterized by hepatic fat accumulation (steatosis) and is associated with obesity, diabetes, and fibrosis or cirrhosis of the liver. Probiotics may be useful in the treatment of steatosis. This study examined the effects of an ingested probiotic formulation on the lipid profiles, liver functions, leptin levels, and inflammatory marker levels of rats with NAFLD that had been induced via high fat and sucrose diet (HFSD)...
January 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28057371/3-meo-pcp-intoxication-in-two-young-men-first-in-vivo-detection-in-italy
#2
Elisabetta Bertol, Jennifer Pascali, Diego Palumbo, Valeria Catalani, Maria Grazia Di Milia, Alessia Fioravanti, Francesco Mari, Fabio Vaiano
3-MeO-PCP or 3-methoxyphencyclidine is a derivative of phencyclidine. It acts as a dissociative anesthetic and it has allegedly hallucinogenic and sedative effects. There are almost no documented intoxication cases and references about its pharmacology and toxicity in literature. This study presents two concomitant intoxication cases due to consumption of 3-MeO-PCP and alcohol. A 19 (A) and a 21 years old (B) men were brought to Santa Maria Nuova Hospital in a comatose state (Glasgow score 3). They showed respiratory acidosis, right anisocoria with mydriatic pupils and hypothermia...
December 26, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28056552/soy-protein-isolate-inhibits-hepatic-tumor-promotion-in-mice-fed-a-high-fat-liquid-diet
#3
Kelly E Mercer, Casey F Pulliam, Kim B Pedersen, Leah Hennings, Martin Jj Ronis
Alcoholic and nonalcoholic fatty liver diseases are risk factors for development of hepatocellular carcinoma, but the underlying mechanisms are poorly understood. On the other hand, ingestion of soy-containing diets may oppose the development of certain cancers. We previously reported that replacing casein with a soy protein isolate reduced tumor promotion in the livers of mice with alcoholic liver disease after feeding a high fat ethanol liquid diet following initiation with diethylnitrosamine. Feeding soy protein isolate inhibited processes that may contribute to tumor promotion including inflammation, sphingolipid signaling, and Wnt/β-catenin signaling...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28042657/the-influence-of-mixers-containing-artificial-sweetener-or-different-doses-of-carbohydrate-on-breath-alcohol-responses-in-females
#4
Cassie Smith, Peter John Herzig, Andrew Davey, Ben Desbrow, Christopher Irwin
BACKGROUND: Breath alcohol responses may be affected by the presence of carbohydrate (CHO) in a beverage. This study investigated the impact of consuming alcohol with mixers containing various doses of CHO or an artificial sweetener on breath alcohol concentration (BrAC), ratings of intoxication and impairment, and cognitive performance in females. METHODS: Twenty-six females (age 25.1 ± 0.7 years, mean ± standard deviation) completed a crossover study involving 4 trials...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28034722/specific-regions-of-the-brain-are-capable-of-fructose-metabolism
#5
Sarah A Oppelt, Wanming Zhang, Dean R Tolan
High fructose consumption in the Western diet correlates with disease states such as obesity and metabolic syndrome complications, including type II diabetes, chronic kidney disease, and non-alcoholic fatty acid liver disease. Liver and kidneys are responsible for metabolism of 40-60% of ingested fructose, while the physiological fate of the remaining fructose remains poorly understood. The primary metabolic pathway for fructose includes the fructose-transporting solute-like carrier transport proteins 2a (SLC2a or GLUT), including GLUT5 and GLUT9, ketohexokinase (KHK), and aldolase...
December 26, 2016: Brain Research
https://www.readbyqxmd.com/read/28034556/who-falls-in-an-adult-emergency-department-and-why-a-retrospective-review
#6
Deanne R McErlean, James A Hughes
INTRODUCTION: Falls are a significant source of healthcare related morbidity and mortality of patients in hospitals and residential healthcare settings. Commonly falls are thought of as an affliction of the elderly and the frail. The emergency department (ED) is a unique healthcare setting that sees patients in the acute and hyper acute stages of physical and mental illness and intoxication. Falls occur in this setting, however there is little knowledge about the factors that influence falls in the emergency department...
December 26, 2016: Australasian Emergency Nursing Journal: AENJ
https://www.readbyqxmd.com/read/28029386/occurrence-of-organophosphorus-flame-retardants-on-skin-wipes-insight-into-human-exposure-from-dermal-absorption
#7
Xiaotu Liu, Gang Yu, Zhiguo Cao, Bin Wang, Jun Huang, Shubo Deng, Yujue Wang
This study surveyed occurrences and influencing factors of organophosphorus flame retardants (PFRs) on skin surface. Skin wipe samples from palms, back-of-hands and forearms of 30 adults were collected by using gauze pads soaked in isopropyl alcohol in Beijing, China. Tris(chloropropyl) phosphate isomers (∑TCPP), tris(2-chloroethyl) phosphate (TCEP) and triphenyl phosphate (TPHP) were the most abundant compounds with detection frequencies higher than 97%. ∑TCPP showed the highest mean level (4.6μg/m(2)), followed by TPHP (2...
October 28, 2016: Environment International
https://www.readbyqxmd.com/read/27995280/dietary-fructose-as-a-risk-factor-for-non-alcoholic-fatty-liver-disease-nafld
#8
REVIEW
Salamah Mohammad Alwahsh, Rolf Gebhardt
Glucose is a major energy source for the entire body, while fructose metabolism occurs mainly in the liver. Fructose consumption has increased over the last decade globally and is suspected to contribute to the increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is a manifestation of metabolic syndrome affecting about one-third of the population worldwide and has progressive pathological potential for liver cirrhosis and cancer through non-alcoholic steatohepatitis (NASH). Here we have reviewed the possible contribution of fructose to the pathophysiology of NAFLD...
December 19, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27979481/postoperative-delirium-is-associated-with-increased-intensive-care-unit-and-hospital-length-of-stays-after-liver-transplantation
#9
Bishwajit Bhattacharya, Adrian Maung, Kimberly Barre, Linda Maerz, Manuel I Rodriguez-Davalos, Michael Schilsky, David C Mulligan, Kimberly A Davis
BACKGROUND: Delirium is increasingly recognized as a common and important postoperative complication that significantly hinders surgical recovery. However, there is a paucity of data examining the incidence and impact of delirium after liver transplantation. METHODS: Retrospective case series in a tertiary care center examining all (n = 144) adult patients who underwent liver transplantation during a 6-y period. RESULTS: Delirium occurred in 25% of the patients with an average duration of 4...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27978861/a-prospective-analysis-of-patients-presenting-for-medical-attention-at-a-large-electronic-dance-music-festival
#10
Matt S Friedman, Alex Plocki, Antonios Likourezos, Illya Pushkar, Andrew N Bazos, Christian Fromm, Benjamin W Friedman
Mass-Gathering Medicine studies have identified variables that predict greater patient presentation rates (PPRs) and transport to hospital rates (TTHRs). This is a descriptive report of patients who presented for medical attention at an annual electronic dance music festival (EDMF). At this large, single EDMF in New York City (NYC; New York, USA), the frequency of patient presentation, the range of presentations, and interventions performed were identified. This descriptive report examined consecutive patients who presented to the medical tent of a summertime EDMF held at an outdoor venue with an active, mobile, bounded crowd...
December 16, 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/27957462/a-stochastic-model-for-the-ethanol-pharmacokinetics
#11
Mazyar Ghadirinejad, Emine Atasoylu, Gökhan Izbirak, Matina Gha-Semi
BACKGROUND: The aim of this study was to propose a new stochastic model to study the time course of ethanol elimination in human bodies. METHODS: The times and amount of alcohol ingested are assumed to be random in controllable intervals. Constant elimination rate follows zero order kinetics and is replaced by first order kinetics when the effects of alcohol increase due to alcohol ingestion. Simulation studies of three different models were made to compare the statistical characteristics of the ethanol effects obtained using analytical expressions...
September 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27939548/using-plant-wax-markers-to-estimate-the-diet-composition-of-grazing-holstein-dairy-cows
#12
C Heublein, K-H Südekum, F L Gill, F Dohme-Meier, F Schori
The objective of this study was to test whether diet selection of dairy cows under grazing conditions could be estimated using plant wax markers. Furthermore, differences between 2 cow strains and the effect of concentrate supplementation on plant species selection were investigated. The experiment was a study with a crossover design performed on an organic farm with 12 Swiss Holstein cows and 12 New Zealand Holstein cows. Both experimental periods consisted of a 21-d adaptation and a 7-d measurement period...
December 8, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27919738/long-term-ethanol-self-administration-induces-%C3%AE-fosb-in-male-and-female-adolescent-but-not-in-adult-wistar-rats
#13
Aranza Wille-Bille, Soledad de Olmos, Leonardo Marengo, Florencia Chiner, Ricardo Marcos Pautassi
Early-onset ethanol consumption predicts later development of alcohol use disorders. Age-related differences in reactivity to ethanol's effects may underlie this effect. Adolescent rats are more sensitive and less sensitive than adults to the appetitive and aversive behavioral effects of ethanol, respectively, and more sensitive to the neurotoxic effects of experimenter-administered binge doses of ethanol. However, less is known about age-related differences in the neural consequences of self-administered ethanol...
March 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27878202/presence-of-orally-administered-rice-bran-oil-%C3%AE-oryzanol-in-its-intact-form-in-mouse-plasma
#14
Eri Kobayashi, Junya Ito, Shunji Kato, Kazue Sawada, Midori Matsuki, Hiroyuki Hashimoto, Teruo Miyazawa, Kiyotaka Nakagawa
Although the beneficial effects (e.g., lipid-lowering activity) of γ-oryzanol (OZ), a mixture of ferulic acid esters of plant sterols and triterpene alcohols, have been extensively investigated, few studies have evaluated the absorption and metabolism of OZ. Moreover, it is unclear whether OZ, once ingested, is directly absorbed by the intestine into the bloodstream at a sufficient level to exhibit activity. Here, we prepared OZ concentrate from purified rice bran oil (Rice Oil OZ), determined the concentration of OZ in the preparation (cycloartenyl ferulate equivalent concentration; 52...
December 7, 2016: Food & Function
https://www.readbyqxmd.com/read/27876672/is-there-a-human-health-risk-associated-with-indirect-exposure-to-perfluoroalkyl-carboxylates-pfcas
#15
Amy A Rand, Scott A Mabury
The production and widespread use of poly- and perfluoroalkyl substances (PFAS) has led to their presence in the environment, wildlife, and humans. Particularly, the perfluoroalkyl carboxylates (PFCAs) are pervasive throughout the world and have been found at ng/mL concentrations in human blood. PFCAs, especially those having longer carbon chain lengths (≥C6), are associated with developmental and hormonal effects, immunotoxicity, and promote tumor growth in rodents through their role as PPARα agonists. Humans are directly exposed to PFCAs primarily through contaminated food, drinking water, and house dust...
January 15, 2017: Toxicology
https://www.readbyqxmd.com/read/27872968/new-functions-and-potential-applications-of-amino-acids
#16
Hisayuki Uneyama, Hisamine Kobayashi, Naoto Tonouchi
Currently, several types of amino acids are being produced and used worldwide. Nevertheless, several new functions of amino acids have been recently discovered that could result in other applications. For example, oral stimulation by glutamate triggers the cephalic phase response to prepare for food digestion. Further, the stomach and intestines have specific glutamate-recognizing systems in their epithelial mucosa. Regarding clinical applications, addition of monosodium glutamate to the medicinal diet has been shown to markedly enhance gastric secretion in a vagus-dependent manner...
November 22, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27861506/chronic-alcohol-ingestion-delays-t-cell-activation-and-effector-function-in-sepsis
#17
Lindsay M Margoles, Rohit Mittal, Nathan J Klingensmith, John D Lyons, Zhe Liang, Mara A Serbanescu, Maylene E Wagener, Craig M Coopersmith, Mandy L Ford
Sepsis is the leading cause of death in intensive care units in the US, and it is known that chronic alcohol use is associated with higher incidence of sepsis, longer ICU stays, and higher mortality from sepsis. Both sepsis and chronic alcohol use are associated with immune deficits such as decreased lymphocyte numbers, impaired innate immunity, delayed-type hypersensitivity reactions, and susceptibility to infections; however, understanding of specific pathways of interaction or synergy between these two states of immune dysregulation is lacking...
2016: PloS One
https://www.readbyqxmd.com/read/27852275/social-inequalities-in-health-behaviors-among-brazilian-adults-national-health-survey-2013
#18
Marilisa Berti de Azevedo Barros, Margareth Guimarães Lima, Lhais de Paula Barbosa Medina, Celia Landman Szwarcwald, Deborah Carvalho Malta
BACKGROUND: Considering the high socioeconomic inequalities prevailing in Brazil and lifestyle as a strong determinant of morbidity and premature mortality, our purpose was to evaluate the degree of socioeconomic disparities in the prevalence of health behaviors among Brazilian adult population using data from the 2013 Brazilian National Health Survey. METHOD: Based on a sample of 49,025 individuals aged 20 to 59 years, we estimated the prevalence of several health behaviors and a score of unhealthy behaviors according to gender, education, race/color and possession of private health insurance...
November 17, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27827799/amitraz-poisoning-an-unusual-cause-of-respiratory-and-peripheral-circulatory-failure
#19
Ishwar Agrawal, Sohaib Ahmad, Manoj Kumar, Mohamad Akram
We report a case of respiratory failure with unconsciousness in an adult occurring within 1 h of ingestion of a pesticide, amitraz, along with alcohol with a suicidal intent. Although commonly available and potentially fatal, this compound is not usually used as a suicidal agent.
November 8, 2016: Tropical Doctor
https://www.readbyqxmd.com/read/27827004/initial-experience-with-hand-assisted-laparoscopic-donor-nephrectomy-a-single-centre-experience-over-5-years
#20
Majken Højrup Wiborg, Anja Toft, Henrik Jahn, Lars Ulrich Hansen, Lars Lund
OBJECTIVE: The objective of this study was to evaluate outcome after hand-assisted live donor nephrectomy with a retroperitoneal approach during a 5 year period. MATERIALS AND METHODS: All donor nephrectomies at Odense University Hospital, Denmark, from January 2008 to December 2012 were identified retrospectively, and the medical records were examined. RESULTS: In total, 108 patients were enrolled: 68 females, with a median age of 50 years (range 24-68 years), and 40 males, with a median age of 51 years (32-70 years)...
November 9, 2016: Scandinavian Journal of Urology
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