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Alcohol ingestion

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https://www.readbyqxmd.com/read/29673827/menopause-ageing-and-alcohol-use-disorders-in-women
#1
REVIEW
Jelena Milic, Marija Glisic, Trudy Voortman, Laura Pletsch Borba, Eralda Asllanaj, Lyda Z Rojas, Jenna Troup, Jessica C Kiefte-de Jong, Ed van Beeck, Taulant Muka, Oscar H Franco
Alcohol intake affects the female body differently than it affects the male body. This is caused by females' lower levels of dehydrogenase enzymes, the enzyme that breaks down alcohol, coupled with the higher fat/water ratio of the female body. Both these factors cause alcohol levels to rise more quickly after ingestion in women than in men. This makes females more vulnerable to alcohol's harmful effects, and consequently women tend to develop alcohol-related diseases earlier in life than do men. As women age and go through menopause, they experience changes in body composition and life changes like retirement or loss of a loved one...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29664837/chronic-alcohol-ingestion-worsens-survival-and-alters-gut-epithelial-apoptosis-and-cd8-t-cell-function-after-pseudomonas-aeruginosa-pneumonia-induced-sepsis
#2
Nathan J Klingensmith, Katherine T Fay, John D Lyons, Ching-Wen Chen, Shunsuke Otani, Zhe Liang, Deena B Chihade, Eileen M Burd, Mandy L Ford, Craig M Coopersmith
Mortality is higher in septic patients with a history of alcohol use disorder than in septic patients without a history of chronic alcohol usage. We have previously described a model of chronic alcohol ingestion followed by sepsis from cecal ligation and puncture in which alcohol-fed septic mice have higher mortality than water-fed septic mice, associated with altered gut integrity and increased production of TNF and IFNγ by splenic CD4 T cells without alterations in CD8 T cell function. The purpose of this study was to determine whether this represents a common host response to the combination of alcohol and sepsis by creating a new model in which mice with chronic alcohol ingestion were subjected to a different model of sepsis...
April 16, 2018: Shock
https://www.readbyqxmd.com/read/29627377/fgf21-a-liver-hormone-that-inhibits-alcohol-intake-in-mice-increases-in-human-circulation-after-acute-alcohol-ingestion-and-sustained-binge-drinking-at-oktoberfest
#3
Susanna Søberg, Emilie S Andersen, Niels B Dalgaard, Ida Jarlhelt, Nina L Hansen, Nina Hoffmann, Tina Vilsbøll, Anne Chenchar, Michal Jensen, Trisha J Grevengoed, Sam A J Trammell, Filip K Knop, Matthew P Gillum
OBJECTIVE: Excessive alcohol consumption is a leading cause of global morbidity and mortality. However, knowledge of the biological factors that influence ad libitum alcohol intake may be incomplete. Two large studies recently linked variants in the KLB locus with levels of alcohol intake in humans. KLB encodes β-klotho, co-receptor for the liver-derived hormone fibroblast growth factor 21 (FGF21). In mice, FGF21 reduces alcohol intake, and human Fgf21 variants are enriched among heavy drinkers...
March 27, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29626769/chemical-profiling-of-pm-10-from-urban-road-dust
#4
C A Alves, M Evtyugina, A M P Vicente, E D Vicente, T V Nunes, P M A Silva, M A C Duarte, C A Pio, F Amato, X Querol
Road dust resuspension is one of the main sources of particulate matter with impacts on air quality, health and climate. With the aim of characterising the thoracic fraction, a portable resuspension chamber was used to collect road dust from five main roads in Oporto and an urban tunnel in Braga, north of Portugal. The PM10 samples were analysed for: i) carbonates by acidification and quantification of the evolved CO2 , ii) carbonaceous content (OC and EC) by a thermo-optical technique, iii) elemental composition by ICP-MS and ICP-AES after acid digestion, and iv) organic speciation by GC-MS...
April 4, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29626671/bioactivities-of-decoctions-from-plectranthus-species-related-to-their-traditional-use-on-the-treatment-of-digestive-problems-and-alcohol-intoxication
#5
Elsa Brito, Emma Gomes, Pedro L Falé, Carlos Borges, Rita Pacheco, Vitor Teixeira, Miguel Machuqueiro, Lia Ascensão, Maria Luisa M Serralheiro
ETHNOPHARMACOLOGICAL RELEVANCE: Decoctions of Plectranthus species are traditionally ingested after large meals for treatment of food digestion and alcohol abuse. AIM OF THE STUDY: This study aims at associating the digestion-related ethno-uses of Plectranthus species decoctions to molecular mechanism that might explain them: easing digestion (AChE inhibition) and treating hangover (ADH inhibition) MATERIAL AND METHODS: Decoctions from Plectranthus species were analysed for their alcohol dehydrogenase (ADH) inhibition and acetylcholinesterase (AChE) inhibition, related with alcohol metabolism and intestinal motility, respectively...
April 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29623043/developmental-ethanol-exposure-causes-reduced-feeding-and-reveals-a-critical-role-for-neuropeptide-f-in-survival
#6
Amanda Guevara, Hillary Gates, Brianna Urbina, Rachael French
Food intake is necessary for survival, and natural reward circuitry has evolved to help ensure that animals ingest sufficient food to maintain development, growth, and survival. Drugs of abuse, including alcohol, co-opt the natural reward circuitry in the brain, and this is a major factor in the reinforcement of drug behaviors leading to addiction. At the junction of these two aspects of reward are alterations in feeding behavior due to alcohol consumption. In particular, developmental alcohol exposure (DAE) results in a collection of physical and neurobehavioral disorders collectively referred to as Fetal Alcohol Spectrum Disorder (FASD)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29618077/n-ethyl-pentylone-ephylone-intoxications-quantitative-confirmation-and-metabolite-identification-in-authentic-human-biological-specimens
#7
Alex J Krotulski, Donna M Papsun, Bruno S De Martinis, Amanda L A Mohr, Barry K Logan
N-ethyl pentylone (ephylone) has been identified as the most recent novel stimulant to emerge into the arena of evolving novel psychoactive substances (NPS). Due to its novelty, information regarding case reports with associated quantitative confirmations, biotransformation pathways, and identified unique metabolites will assist the scientific community in understanding the implications of the emergence and risks associated with N-ethyl pentylone use. Authentic blood specimens (n = 26) submitted as part of toxicological death investigations or drugged driving casework tested positive for N-ethyl pentylone, and were quantitatively analyzed by liquid chromatography tandem mass spectrometry (LC-MS-MS)...
March 31, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29609113/prevention-of-alcohol-induced-dna-damage-by-a-proprietary-glycyrrhizin-d-mannitol-product-a-randomized-placebo-controlled-cross-over-human-study
#8
Harsha Chigurupati, Biswajit Auddy, Manish Biyani, Shrabana Chakrabarti, Sidney J Stohs
OBJECTIVES: The purpose of the present study was to evaluate the ability of a proprietary combination of glycyrrhizin and D-mannitol to protect against oxidative damage to DNA associated with acute alcohol consumption by human subjects in a randomized, placebo-controlled cross-over designed study. Excessive alcohol consumption is associated with numerous diseases. Alcohol has been shown to generate reactive oxygen species that can result in DNA damage, leading to genetic and epigenetic changes...
November 6, 2017: Alcohol
https://www.readbyqxmd.com/read/29605069/acetaminophen-apap-or-n-acetyl-p-aminophenol-and-acute-liver-failure
#9
REVIEW
Chalermrat Bunchorntavakul, K Rajender Reddy
Acetaminophen (APAP) is the leading cause of acute liver failure (ALF), although the worldwide frequency is variable. APAP hepatotoxicity develops either following intentional overdose or unintentional ingestion (therapeutic misadventure) in the background of several factors, such as concomitant use of alcohol and certain medications that facilitate the formation of reactive and toxic metabolites. Spontaneous survival is more common in APAP-induced ALF compared with non-APAP etiologies. N-acetylcysteine is recommended for all patients with APAP-induced ALF and it reduces mortality...
May 2018: Clinics in Liver Disease
https://www.readbyqxmd.com/read/29597305/effects-of-consuming-a-low-dose-of-alcohol-with-mixers-containing-carbohydrate-or-artificial-sweetener-on-simulated-driving-performance
#10
Bryce Brickley, Ben Desbrow, Danielle McCartney, Christopher Irwin
The Australian National Drug and Alcohol Research Centre (NDARC) devised gender-based drinking recommendations to ensure blood or equivalized breath alcohol concentrations (BrAC) remain <0.050%. However, these may be inappropriate for individuals consuming alcohol without carbohydrate (CHO), which results in higher BrACs. This study investigated the effects of ingesting alcohol with and without CHO on BrACs and simulated driving performance. Thirty-two participants (16 males; age: 23 ± 6 years) completed two randomized single-blinded trials...
March 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29590379/increased-plasma-proneurotensin-levels-identify-nafld-in-adults-with-and-without-type-2-diabetes
#11
Ilaria Barchetta, Flavia Agata Cimini, Frida Leonetti, Danila Capoccia, Claudio Di Cristofano, Gianfranco Silecchia, Marju Orho-Melander, Olle Melander, Maria Gisella Cavallo
Context: Neurotensin (NT) is an intestinal peptide released by fat ingestion and promoting lipids absorption; higher circulating NT levels associate with type 2 diabetes (T2D), obesity and cardiovascular disease. Whether NT is related to non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) has not been fully investigated. Objective: To study the relationship between plasma proneurotensin1-117 (pro-NT), a stable fragment of the NT precursor hormone, and the presence/severity of NAFLD/NASH and to unravel correlates of increased pro-NT levels...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29590149/increased-ethanol-consumption-after-interruption-of-fat-bingeing
#12
M Carmen Blanco-Gandía, José Miñarro, Maria Asuncion Aguilar, Marta Rodríguez-Arias
There is a marked comorbidity between alcohol abuse and eating disorders, especially in the young population. We have previously reported that bingeing on fat during adolescence increases the rewarding effects of ethanol (EtOH). The aim of the present work was to study if vulnerability to EtOH persists after cessation of binge eating. OF1 mice binged on fat (HFB: high-fat binge) during adolescence (PND 25-43) and were tested for 15 days after the last access to HFB (on PND 59) using the self-administration paradigm, the conditioned place preference (CPP) and locomotor sensitization to ethanol...
2018: PloS One
https://www.readbyqxmd.com/read/29581918/steroids-and-thyrotoxicosis-precipitate-periodic-paralysis
#13
Rizwan Ahamed, Sarah McCalley, Anupam A Sule
Thyrotoxic Periodic Paralysis (TPP) belongs to a group of muscle diseases called channelopathies, which present with painless generalized muscle weakness without exertion. TPP can be precipitated by a large carbohydrate meal, stress, strenuous exercise, alcohol, a high-salt diet, menstruation, and cold temperatures. Rarely, steroids such as dexamethasone can also precipitate a TPP attack. A 29-year-old Hispanic male, with a history of hyperthyroidism, presented to the emergency department with progressive weakness, predominantly in the lower extremities since morning...
January 23, 2018: Curēus
https://www.readbyqxmd.com/read/29569090/author-correction-toxic-alcohol-diagnosis-and-management-an-emergency-medicine-review
#14
Patrick Chow Ng, Brit J Long, William Tyler Davis, Daniel J Sessions, Alex Koyfman
Toxic alcohols are a group of substances containing a hydroxyl group not meant to be ingested. They are the cause of a significant number of accidental and non-accidental exposures. Toxic alcohol poisoning can be associated with a significant degree of morbidity and mortality if not promptly recognized and treated. This review describes the clinical presentation and an approach to the recognition and management for toxic alcohol poisoning. Toxic alcohols classically refer to a group of alcohols not meant for ingestion...
March 22, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29566195/lifestyle-metabolite-and-genetic-determinants-of-formate-concentrations-in-a-cross-sectional-study-in-young-healthy-adults
#15
John T Brosnan, James L Mills, Per M Ueland, Barry Shane, Ruzong Fan, Chi-Yang Chiu, Faith Pangilinan, Lawrence C Brody, Margaret E Brosnan, Theerawat Pongnopparat, Anne M Molloy
Background: Formate is an important metabolite that serves as a donor of one-carbon groups to the intracellular tetrahydrofolate pool. However, little is known of its circulating concentrations or of their determinants. Objective: This study aimed to define formate concentrations and their determinants in a healthy young population. Design: Serum formate was measured in 1701 participants from the Trinity Student Study. The participants were men and women, aged 18 to 28 y, enrolled at Trinity College, Dublin...
March 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29559422/representations-of-codeine-misuse-on-instagram-content-analysis
#16
Roy Cherian, Marisa Westbrook, Danielle Ramo, Urmimala Sarkar
BACKGROUND: Prescription opioid misuse has doubled over the past 10 years and is now a public health epidemic. Analysis of social media data may provide additional insights into opioid misuse to supplement the traditional approaches of data collection (eg, self-report on surveys). OBJECTIVE: The aim of this study was to characterize representations of codeine misuse through analysis of public posts on Instagram to understand text phrases related to misuse. METHODS: We identified hashtags and searchable text phrases associated with codeine misuse by analyzing 1156 sequential Instagram posts over the course of 2 weeks from May 2016 to July 2016...
March 20, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29550583/yawning-elicited-by-intravenous-ethanol-in-rhesus-monkeys-with-experience-self-administering-cocaine-and-ethanol-involvement-of-dopamine-d-3-receptors
#17
Paul W Czoty, William S John, Amy Hauck Newman, Michael A Nader
Characterization of the effects of long-term alcohol consumption on the brain would be aided by the development of behavioral assays that are relatively easy to implement in animal models of alcohol use disorders. Assessing unconditioned behaviors, such as drug-elicited yawning in models that permit long-term alcohol ingestion, may be a valuable complement to more invasive and costly procedures. The present studies investigated previous unexpected findings of ethanol-induced yawning in nonhuman primates. Subjects were adult male rhesus monkeys (n = 8), all of which had experience self-administering intravenous cocaine for several years...
October 17, 2017: Alcohol
https://www.readbyqxmd.com/read/29542842/beer-effects-on-postprandial-digestive-symptoms-and-gastroesophagic-physiology
#18
B Serrano Falcón, M Megía Sánchez, A Ruiz de León, E Rey
BACKGROUND: Beer has been related to gastroesophageal reflux (GER) and dyspepsia, based on its alcohol and gas content. The aim of this study is to evaluate the association between moderate consumption of traditional and alcohol-free beer and upper digestive symptoms, gastric accommodation and GER. METHODS: Healthy adults without frequent gastrointestinal symptoms and GER disease were included. The intervention involved administration of traditional beer to 10 subjects (substudy 1) and alcohol-free beer to 20 (substudy 2); control intervention entailed administration of water...
March 15, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29514131/potential-of-resveratrol-in-mitigating-metabolic-disturbances-induced-by-ethanol
#19
REVIEW
Tomasz Szkudelski, Katarzyna Szkudelska
Alcohol abuse is associated with numerous health problems, including metabolic disturbances and liver damage. Therefore, different compounds are continuously being tested to evaluate their potential effectiveness in reducing these harmful changes. Animal studies clearly show that resveratrol is capable of ameliorating some consequences of ethanol ingestion. Resveratrol is a naturally occurring diphenolic compound having pleiotropic, health-promoting properties. Its beneficial action have been also demonstrated in animal models with ethanol-induced metabolic disturbances and liver injury...
March 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29513625/leveraging-user-perspectives-for-insight-into-cannabis-concentrates
#20
Patricia A Cavazos-Rehg, Melissa J Krauss, Shaina J Sowles, Glennon M Floyd, Elizabeth S Cahn, Veronica L Chaitan, Marisel Ponton
BACKGROUND: The US has seen an increase in the popularity of highly concentrated forms of cannabis (hereafter concentrates) and too little is known about the potential risks associated with their use. OBJECTIVES: The present study aims to better understand the patterns and outcomes of concentrates use through the perspectives of young adult users. METHODS: Participants (N = 234, 27.9% female) aged 18-35 years were recruited using SurveyMonkey Audience® and had ingested concentrates at least once in the past 6 months...
March 7, 2018: American Journal of Drug and Alcohol Abuse
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