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https://www.readbyqxmd.com/read/28317048/acth-producing-neuroendocrine-tumor-of-the-pancreas-a-case-report-and-literature-review
#1
Justin Byun, Sung Hyun Kim, Hyang Sook Jeong, Yumie Rhee, Woo Jung Lee, Chang Moo Kang
Tumors that arise from the endocrine pancreas, or the islets of pancreas, are called pancreatic neuroendocrine tumors (NETs). Pancreatic NET have an incidence of <0.1 per one million persons, and can lead to secretion of ectopic adrenocorticotropic hormone (ACTH). Herein, we presented a case of patient with Cushing's syndrome as a result of ACTH-producing pancreatic NET, who underwent successful laparoscopic distal pancreatosplenectomy. A 40-year-old Korean female patient with ophthalmologic discomfort, osteoporosis, and unexplained hypokalemia was admitted to our hospital...
February 2017: Ann Hepatobiliary Pancreat Surg
https://www.readbyqxmd.com/read/28285638/ectopic-fat-accumulation-in-the-pancreas-and-its-clinical-relevance-a-systematic-review-meta-analysis-and-meta-regression
#2
REVIEW
Ruma G Singh, Harry D Yoon, Landy M Wu, Jun Lu, Lindsay D Plank, Maxim S Petrov
OBJECTIVE: Growing evidence suggests that individuals with excessive fat in the pancreas are at an increased risk of chronic metabolic disorders. The aim was to systematically review studies on non-alcoholic fatty pancreas disease (NAFPD) with a view to determine its prevalence, associations with metabolic co-morbidities, and to suggest normal pancreatic fat percentage threshold. METHODS: Three electronic databases (MEDLINE, Scopus, and Embase) were queried. Studies in humans were eligible for inclusion if they provided data on NAFPD and/or pancreatic fat percentage...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28276827/direct-endoscopic-biopsy-for-subepithelial-tumor-larger-than-20%C3%A2-mm-after-removal-of-overlying-mucosa
#3
Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Su Jin Kim, Sun Hwi Hwang, Si Hak Lee
OBJECTIVE: An accurate diagnosis of a subepithelial tumor (SET) using endoscopic ultrasound (EUS) without tissue acquisition is difficult. Treatment plan for a SET may be influenced by endoscopic tissue diagnosis. We aimed to clarify the clinical outcomes of direct endoscopic biopsy for SET after removal of the overlying mucosa. METHODS: We evaluated the medical records of 15 patients. All patients underwent direct endoscopic biopsy for a SET larger than 20 mm (involving proper muscle layer) after removal of the overlying mucosa...
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28220958/contrast-enhanced-harmonic-endoscopic-ultrasonography-for-differential-diagnosis-of-submucosal-tumors-of-the-upper-gastrointestinal-tract
#4
Ken Kamata, Mamoru Takenaka, Masayuki Kitano, Shunsuke Omoto, Takeshi Miyata, Kosuke Minaga, Kentaro Yamao, Hajime Imai, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Takaaki Chikugo, Yasutaka Chiba, Haruhiko Imamoto, Takushi Yasuda, Andrea Lisotti, Pietro Fusaroli, Masatoshi Kudo
BACKGROUND AND AIMS: To evaluate contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) for the differential diagnosis of submucosal tumors (SMT) of the upper gastrointestinal tract. METHODS: Between June 2008 and May 2015, 157 consecutive patients with submucosal lesions of the upper gastrointestinal tract were evaluated by CH-EUS. This was a single-center retrospective analysis of prospectively collected data in a registry. The data from 73 patients who later underwent surgical resection were analyzed in this study...
February 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28187871/hyperamylasaemia-and-gastrointestinal-bleeding-as-the-first-manifestation-of-jejunal-ectopic-pancreas
#5
Iago Rodríguez-Lago, María Navajas, Margarita Durán, Amaia Martínez, Soraya Torres, Marta Aduna, Leire Etxegarai, José Luis Cabriada
No abstract text is available yet for this article.
February 7, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28162956/exercise-and-ectopic-fat-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#6
REVIEW
A Sabag, K L Way, S E Keating, R N Sultana, H T O'Connor, M K Baker, V H Chuter, J George, N A Johnson
Ectopic adipose tissue surrounding the intra-abdominal organs (visceral fat) and located in the liver, heart, pancreas and muscle, is linked to cardio-metabolic complications commonly experienced in type 2 diabetes. A systematic review and meta-analysis was performed to determine the effect of exercise on ectopic fat in adults with type 2 diabetes. Relevant databases were searched to February 2016. Included were randomised controlled studies, which implemented≥4 weeks of aerobic and/or resistance exercise and quantified ectopic fat via magnetic resonance imaging, computed tomography, proton magnetic resonance spectroscopy or muscle biopsy before and after intervention...
February 2, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28151472/calcb-splice-region-pathogenic-variants-leading-to-plasma-cell-neurotropic-enrichment-in-type-1-autoimmune-pancreatitis
#7
Qi-Cai Liu, Falin Chen, Chao-Yang Wu, Feng Gao, Ze-Hao Zhuang, Jin-Tong Chen, Bin Cai, Tianming Zhang, Ling Guo, Li-Qing Lin, Cheng-Fei Zhao, Xin-Hua Lin
Recently, we have demonstrated that PRSS1 mutations cause ectopic trypsinogen activation and thereby result in type 1 autoimmune pancreatitis (AIP). However, the molecules involved in inducing obliterative vasculitis and perineural inflammation in the pancreas are not well-described. The present study applied whole-exome sequencing (WES) to determine the underlying etiology and revealed novel missense splice region variants, CALCB c.88T>C (p.Ser30Pro) and IR [1]-mutants, in 2 of the 3 families and 2 of 26 unrelated patients with type 1 AIP...
February 2, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28131064/gastric-duplication-cyst-gdc-associated-with-ectopic-pancreas-case-report-and-review-of-the-literature
#8
I D Passos, G Chatzoulis, K Milias, E Tzoi, C Christoforakis, P Spyridopoulos
INTRODUCTION: Duplication of the alimentary tract is a relatively rare congenital anomaly. It can affect any part of the gastrointestinal tract, with ileum being the most common site. These malformations are believed to be congenital, formed before the differentiation of epithelial lining, and therefore named for the organ with which they are associated. Duplication cysts of the stomach represent four percent of all alimentary tract duplications. CASE REPORT: Here, we report a rare case of symptomatic duplication cyst of stomach associated with ectopic pancreas presenting in adult...
January 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28122316/bowel-obstruction-secondary-to-an-ectopic-pancreas-in-the-small-bowels-about-2-cases
#9
Haydar A Nasser, Youssef A Sleiman, Ziad A Hassoun, Mohamad Elzaatari, Tarek Berjawi, Wajdi Hamdan, Mustafa Allouch
INTRODUCTION: Ectopic pancreas is most commonly found in the jejunum and stomach. Most patients remain asymptomatic, and the diagnosis is usually made at autopsy or incidentally. We report here 2 cases of intestinal occlusion, secondary to an ectopic pancreatic tissue. Both cases were managed successfully by laparoscopy and laparotomy with subsequent segmental intestinal resection. CASE PRESENTATIONS: Case 1 - An elderly patient presented to the ER because of intestinal occlusion...
January 11, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28121494/minimally-invasive-management-of-ectopic-pancreas
#10
Gerardo A Vitiello, Michael J Cavnar, Cristina Hajdu, Inessa Khaykis, Elliot Newman, Marcovalerio Melis, H Leon Pachter, Steven M Cohen
BACKGROUND: The management of ectopic pancreas is not well defined. This study aims to determine the prevalence of symptomatic ectopic pancreas and identify those who may benefit from treatment, with a particular focus on robotically assisted surgical management. METHODS: Our institutional pathology database was queried to identify a cohort of ectopic pancreas specimens. Additional clinical data regarding clinical symptomatology, diagnostic studies, and treatment were obtained through chart review...
March 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28102481/perforation-of-jejunal-diverticulum-with-ectopic-pancreas
#11
Hiroshi Shiratori, Takeshi Nishikawa, Yukako Shintani, Koji Murono, Kazuhito Sasaki, Koji Yasuda, Kensuke Otani, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa, Soichiro Ishihara, Masashi Fukayama, Toshiaki Watanabe
Perforation of jejunal diverticulum is a rare complication. Here, we report a case of jejunal diverticulum penetration with surrounding ectopic pancreas. An 83-year-old female patient was admitted to our department with acute onset of severe abdominal pain lasting for half a day. Abdominal computed tomography showed outpouching of the small intestine that contained air/fluid, with multiple surrounding air bubbles in the mesentery of the small intestine. She was diagnosed with penetration of the small intestine, and an emergency laparotomy was indicated...
April 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28018109/clinical-implications-of-doubling-time-of-gastrointestinal-submucosal-tumors
#12
Shuko Koizumi, Mitsuhiro Kida, Hiroshi Yamauchi, Kosuke Okuwaki, Tomohisa Iwai, Shiro Miyazawa, Miyoko Takezawa, Hiroshi Imaizumi, Wasaburo Koizumi
AIM: To evaluate the efficacy of doubling time (DT) of gastrointestinal submucosal tumors (GIST). METHODS: From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GISTs on surgical resection or endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in Kitasato University East Hospital or Kitasato University Hospital. We studied 53 of these patients (34 with resected tumors and 19 with unresected tumors) whose tumors could be measured on EUS on at least two successive occasions...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28012279/pancreas-volume-and-fat-deposition-in-diabetes-and-normal-physiology-consideration-of-the-interplay-between-endocrine-and-exocrine-pancreas
#13
Yoshifumi Saisho
The pancreas is comprised of exocrine and endocrine components. Despite the fact that they are derived from a common origin in utero, these two compartments are often studied individually because of the different roles and functions of the exocrine and endocrine pancreas. Recent studies have shown that not only type 1 diabetes (T1D), but also type 2 diabetes (T2D), is characterized by a deficit in beta-cell mass, suggesting that pathological changes in the pancreas are critical events in the natural history of diabetes...
July 2016: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/27941051/vascular-risk-in-obesity-facts-misconceptions-and-the-unknown
#14
REVIEW
Rhodri J King, Ramzi A Ajjan
Obesity is a major burden on healthcare systems worldwide due to the association with numerous complications, arguably the most important of which are the development of type 2 diabetes and cardiovascular disease. Both are thought to develop from similar origins and occur at variable rates in obese individuals, including those with similar body mass indices. This phenomenon is likely a result of an increased susceptibility for the storage of excess fat in the wrong place, namely, ectopic fat surrounding the liver, pancreas and muscles...
January 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/27897432/low-skeletal-muscle-radiation-attenuation-and-visceral-adiposity-are-associated-with-overall-survival-and-surgical-site-infections-in-patients-with-pancreatic-cancer
#15
David P J van Dijk, Maikel J A M Bakens, Mariëlle M E Coolsen, Sander S Rensen, Ronald M van Dam, Martijn J L Bours, Matty P Weijenberg, Cornelis H C Dejong, Steven W M Olde Damink
BACKGROUND: Cancer cachexia and skeletal muscle wasting are related to poor survival. In this study, quantitative body composition measurements using computed tomography (CT) were investigated in relation to survival, post-operative complications, and surgical site infections in surgical patients with cancer of the head of the pancreas. METHODS: A prospective cohort of 199 patients with cancer of the head of the pancreas was analysed by CT imaging at the L3 level to determine (i) muscle radiation attenuation (average Hounsfield units of total L3 skeletal muscle); (ii) visceral adipose tissue area; (iii) subcutaneous adipose tissue area; (iv) intermuscular adipose tissue area; and (v) skeletal muscle area...
October 26, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27864307/pancreatic-%C3%AE-cells-express-the-fetal-islet-hormone-gastrin-in-rodent-and-human-diabetes
#16
Tehila Dahan, Oren Ziv, Elad Horwitz, Hai Zemmour, Judith Lavi, Avital Swisa, Gil Leibowitz, Frances M Ashcroft, Peter In't Veld, Benjamin Glaser, Yuval Dor
β-Cell failure in type 2 diabetes (T2D) was recently proposed to involve dedifferentiation of β-cells and ectopic expression of other islet hormones, including somatostatin and glucagon. Here we show that gastrin, a stomach hormone typically expressed in the pancreas only during embryogenesis, is expressed in islets of diabetic rodents and humans with T2D. Although gastrin in mice is expressed in insulin(+) cells, gastrin expression in humans with T2D occurs in both insulin(+) and somatostatin(+) cells. Genetic lineage tracing in mice indicates that gastrin expression is turned on in a subset of differentiated β-cells after exposure to severe hyperglycemia...
February 2017: Diabetes
https://www.readbyqxmd.com/read/27858880/endoscopic-ultrasound-without-tissue-acquisition-has-poor-accuracy-for-diagnosing-gastric-subepithelial-tumors
#17
Tae Won Lim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Su Jin Kim
Incidental gastric subepithelial tumor (SET) is frequently found during endoscopy. Although endoscopic ultrasonography (EUS) can provide useful information, its diagnostic accuracy varies. Most of the potentially malignant tumors observed on EUS are hypoechoic lesions. Therefore, we aimed to investigate the diagnostic accuracy of EUS for hypoechoic lesions located in the submucosa or proper muscle layer. We also evaluated various characteristics for potential associations with diagnostic accuracy.A retrospective review was conducted of the medical records of 99 patients who were diagnosed with gastric SET and who underwent EUS with pathologic confirmation between March 2008 and April 2015...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27847215/grape-seed-and-skin-extract-reduces-pancreas-lipotoxicity-oxidative-stress-and-inflammation-in-high-fat-diet-fed-rats
#18
Faten Aloui, Kamel Charradi, Aziz Hichami, Selvakumar Subramaniam, Naim Akhtar Khan, Ferid Limam, Ezzedine Aouani
Obesity is related to an elevated risk of diabetes and the mechanisms whereby fat adversely affects the pancreas are poorly understood. We studied the effect of a high fat diet (HFD) on pancreas steatosis, oxidative stress and inflammation as well as the putative protection afforded by grape seed and skin extract (GSSE). HFD induced body weight gain, without affecting insulinemia, nor glycemia and dropped adiponectemia. HFD also provoked the ectopic deposition of cholesterol and triglyceride, and an oxidative stress characterized by increased lipoperoxidation and carbonylation, inhibition of antioxidant enzyme activities such as CAT, GPx and SOD, depletion of zinc and a concomitant increase in calcium and H2O2...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27803770/update-on-endoscopic-management-of-gastric-outlet-obstruction-in-children
#19
REVIEW
Hsun-Chin Chao
Endoscopic balloon dilatation (EBD) and surgical intervention are two most common and effective treatments for gastric outlet obstruction. Correction of gastric outlet obstruction without the need for surgery is an issue that has been tried to be resolved in these decades; this management has developed with EBD, advanced treatments like local steroid injection, electrocauterization, and stent have been added recently. The most common causes of pediatric gastric outlet obstruction are idiopathic hypertrophic pyloric stenosis, peptic ulcer disease followed by the ingestion of caustic substances, stenosis secondary to surgical anastomosis; antral web, duplication cyst, ectopic pancreas, and other rare conditions...
October 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27736991/loss-of-pancreas-upon-activated-wnt-signaling-is-concomitant-with-emergence-of-gastrointestinal-identity
#20
Jose Luis Muñoz-Bravo, Alvaro Flores-Martínez, Griselda Herrero-Martin, Sapna Puri, Makoto Mark Taketo, Anabel Rojas, Matthias Hebrok, David A Cano
Organ formation is achieved through the complex interplay between signaling pathways and transcriptional cascades. The canonical Wnt signaling pathway plays multiple roles during embryonic development including patterning, proliferation and differentiation in distinct tissues. Previous studies have established the importance of this pathway at multiple stages of pancreas formation as well as in postnatal organ function and homeostasis. In mice, gain-of-function experiments have demonstrated that activation of the canonical Wnt pathway results in pancreatic hypoplasia, a phenomenon whose underlying mechanisms remains to be elucidated...
2016: PloS One
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