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https://www.readbyqxmd.com/read/28633420/pancreas-fat-and-beta-cell-mass-in-humans-with-and-without-diabetes-an-analysis-in-the-japanese-population
#1
Rie Murakami, Yoshifumi Saisho, Yuusuke Watanabe, Jun Inaishi, Tami Tsuchiya, Kinsei Kou, Seiji Sato, Minoru Kitago, Yuko Kitagawa, Taketo Yamada, Hiroshi Itoh
Context: The mechanisms by which beta cell mass is reduced in patients with type 2 diabetes (T2DM) remain unclear. It has been postulated that ectopic fat deposits in the pancreas induce beta cell apoptosis, leading to the development of diabetes. Objective: The aim of this study was to clarify the effects of intra-pancreatic fat on beta and alpha cell mass in humans with and without diabetes. Design, Subjects and Methods: Using our tissue database, pancreas sections of 72 Japanese non-diabetic (NDM) autopsy cases and 50 diabetic (DM) and 49 age- and BMI-matched NDM patients who underwent pancreatic surgery were analyzed...
June 14, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28632450/combinations-of-activin-a-or-nicotinamide-with-the-pancreatic-transcription-factor-pdx1-support-differentiation-of-human-amnion-epithelial-cells-toward-a-pancreatic-lineage
#2
Shruti Balaji, Yu Zhou, Emmanuel C Opara, Shay Soker
The differentiation of multipotent stem cells toward a pancreatic lineage provides us with an alternative cell-based therapeutic approach to type 1 diabetes and enables us to study pancreas development. The current study aims to study the effect of growth factors such as activin A or nicotinamide, alone and in combinations with the transcription factor, PDX1 (pancreatic and duodenal homeobox-1), on human amnion epithelial cells (hAECs) toward a pancreatic lineage. Ectopic expression of Pdx1 followed by treatment of hAECs with nicotinamide for 4 days resulted in strong induction of pancreatic endoderm and pancreatic progenitor genes, including NKX6...
June 20, 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28626110/-one-case-of-gastric-duplication-cyst-with%C3%A2-ectopic-pancreas-in-adults
#3
Qi Wang, Ziqing Deng, Xiaofeng Yang, Jiaqing Cao
Gastric duplication cyst is a very rare gastrointestinal tract malformation that accounts for 2%-4% of alimentary tract duplications. It is a diagnostic dilemma for doctors because its clinical and radiological manifest is usually nonspecific. At the present stage, it can only rely on surgery. We should pay attention to ectopic pancreas resection and ligation of pancreatic duct during operation. There was one case of gastric duplication cyst with ectopic pancreas in adults from the Second Affiliated Hospital of Nanchang University...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28617892/intestinal-heterotopic-pancreas-involved-by-simultaneous-panin-2-lesion-and-endocrine-microadenoma-a-unique-case
#4
Remus Cornea, Sorina Taban, Cristian Suciu, Codruta Lazureanu, Alis Dema
We hereby present the case of a 58-year-old male who underwent a total gastrectomy for gastric neoplasm. During the surgery, a tumor mass in the jejunum was identified, considered as metastasis, and resected. The histopathological examination of the jejunal lesion showed ectopic pancreas. In this area, two pathological distinct lesions were identified, one histologically compatible with pancreatic intraepithelial neoplasia (PanIN) type 2 lesion and the other with morphologic criteria for endocrine microadenoma...
June 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28614428/intrapancreatic-accessory-spleen
#5
Marcelo Protásio Dos Santos, Aline Pacheco de Rezende, Paulo Vicente Dos Santos, José Eduardo Gonçalves, Fernando Bray Beraldo, Adriano Pereira Sampaio
An asymptomatic 79-year-old woman, with incidental finding on abdominal ultrasound of a solid nodule in the tail of the pancreas. Magnetic resonance imaging showed a 12mm solid tumor. The suggested diagnosis was pancreatic neuroendocrine tumor. The pathological examination showed an intrapancreatic splenic tissue. This is a rare ectopic location of spleen tissue and it should be considered in the differential diagnosis of pancreatic solid tumors. RESUMO Mulher de 79 anos, com achado incidental em ultrassonografia de abdome de lesão sólida em cauda de pâncreas...
June 12, 2017: Einstein
https://www.readbyqxmd.com/read/28612831/abdominal-obesity-and-type-2-diabetes-in-asian-indians-dietary-strategies-including-edible-oils-cooking-practices-and-sugar-intake
#6
REVIEW
S Gulati, A Misra
Obesity and type 2 diabetes are increasing in rural and urban regions of South Asia including India. Pattern of fat deposition in abdomen, ectopic fat deposition (liver, pancreas) and also low lean mass are contributory to early-onset insulin resistance, dysmetabolic state and diabetes in Asian Indians. These metabolic perturbations are further exacerbated by changing lifestyle, diet urbanization, and mechanization. Important dietary imbalances include increasing use of oils containing high amount of trans fatty acids and saturated fats (partially hydrogenated vegetable oil, palmolein oil) use of deep frying method and reheating of oils for cooking, high intake of saturated fats, sugar and refined carbohydrates, low intake of protein, fiber and increasing intake of processed foods...
June 14, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28587772/gastric-inflammatory-myofibroblastic-tumor-identified-as-ectopic-pancreas-and-treated-by-endoscopic-submucosal-dissection
#7
Xiaoyan Ning, Biao Liang, Qinyi Liu, Xiaowu Chen, Ming Xu
No abstract text is available yet for this article.
June 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28489290/obesity-a-chronic-relapsing-progressive-disease-process-a-position-statement-of-the-world-obesity-federation
#8
EDITORIAL
G A Bray, K K Kim, J P H Wilding
This paper considers the argument for obesity as a chronic relapsing disease process. Obesity is viewed from an epidemiological model, with an agent affecting the host and producing disease. Food is the primary agent, particularly foods that are high in energy density such as fat, or in sugar-sweetened beverages. An abundance of food, low physical activity and several other environmental factors interact with the genetic susceptibility of the host to produce positive energy balance. The majority of this excess energy is stored as fat in enlarged, and often more numerous fat cells, but some lipid may infiltrate other organs such as the liver (ectopic fat)...
July 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28482873/clinical-impact-of-duodenal-pancreatic-heterotopia-is-there-a-need-for-surgical-treatment
#9
Alexander Betzler, Soeren T Mees, Josefine Pump, Sebastian Schölch, Carolin Zimmermann, Daniela E Aust, Jürgen Weitz, Thilo Welsch, Marius Distler
BACKGROUND: Pancreatic heterotopia (PH) is defined as ectopic pancreatic tissue outside the normal pancreas and its vasculature and duct system. Most frequently, PH is detected incidentally by histopathological examination. The aim of the present study was to analyze a large single-center series of duodenal PH with respect to the clinical presentation. METHODS: A prospective pancreatic database was retrospectively analyzed for cases of PH of the duodenum. All pancreatic and duodenal resections performed between January 2000 and October 2015 were included and screened for histopathologically proven duodenal PH...
May 8, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28465633/unusual-gastric-tumors-and-tumor-like-lesions-radiological-with-pathological-correlation-and-literature-review
#10
REVIEW
Yuan-Mao Lin, Nai-Chi Chiu, Anna Fen-Yao Li, Chien-An Liu, Yi-Hong Chou, Yi-You Chiou
Although gastric tumors have overlapping radiologic appearances, some unusual tumors may present specific imaging features. Using multidetector computed tomography (MDCT), with water as a negative oral contrast agent and intravenous contrast medium, can provide critical information for the diagnosis of gastric diseases. In addition, MDCT can evaluate the involvement of the gastric wall and extragastric extent of the disease, as compared with gastroenteroscopy and double-contrast upper gastrointestinal study...
April 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28458856/solid-pseudopapillary-tumor-in-an-ectopic-pancreas-an-unusual-presentation
#11
Sudeep Khaniya, Vikal Chandra Shakya, Rabin Koirala
Pancreatic solid pseudopapillary tumor is a rare neoplasm. Very rarely, it may arise from an ectopic site. Solid pseudopapillary tumor occurring in the root of mesentery has not been described in the literature. This report summarizes a case of an adult male having the tumor arising from the mesenteric root. He underwent complete resection of the tumor followed by six cycles of adjuvant chemotherapy and remains asymptomatic till date.
March 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28442507/protein-kinase-stk25-aggravates-the-severity-of-non-alcoholic-fatty-pancreas-disease-in-mice
#12
Esther Nunez Duran, Belen Chanclon, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt-Asterholm, Emelie Cansby, Margit Mahlapuu
Characterising the molecular networks that negatively regulate pancreatic β-cell function is essential for understanding the underlying pathogenesis and developing new treatment strategies for type 2 diabetes. We recently identified serine/threonine protein kinase 25 (STK25) as a critical regulator of ectopic fat storage, meta-inflammation, and fibrosis in liver and skeletal muscle. Here, we assessed the role of STK25 in control of progression of non-alcoholic fatty pancreas disease in the context of chronic exposure to dietary lipids in mice...
April 25, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28371475/impact-of-non-alcoholic-fatty-pancreas-disease-on-glucose-metabolism
#13
REVIEW
Tse-Ya Yu, Chih-Yuan Wang
With the increasing global epidemic of obesity, the clinical importance of non-alcoholic fatty pancreas disease (NAFPD) has grown. Even though the pancreas might be more susceptible to ectopic fat deposition compared with the liver, NAFPD is rarely discussed because of the limitation of detection techniques. In the past, NAFPD was considered as an innocent condition or just part of clinical manifestations during the course of obesity. Recently, a growing body of research suggests that NAFPD might be associated with β-cell dysfunction, insulin resistance and inflammation, which possibly lead to the development of diabetes and metabolic syndrome...
March 31, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28317048/acth-producing-neuroendocrine-tumor-of-the-pancreas-a-case-report-and-literature-review
#14
Justin Byun, Sung Hyun Kim, Hyang Sook Jeong, Yumie Rhee, Woo Jung Lee, Chang Moo Kang
Tumors that arise from the endocrine pancreas, or the islets of pancreas, are called pancreatic neuroendocrine tumors (NETs). Pancreatic NET have an incidence of <0.1 per one million persons, and can lead to secretion of ectopic adrenocorticotropic hormone (ACTH). Herein, we presented a case of patient with Cushing's syndrome as a result of ACTH-producing pancreatic NET, who underwent successful laparoscopic distal pancreatosplenectomy. A 40-year-old Korean female patient with ophthalmologic discomfort, osteoporosis, and unexplained hypokalemia was admitted to our hospital...
February 2017: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/28285638/ectopic-fat-accumulation-in-the-pancreas-and-its-clinical-relevance-a-systematic-review-meta-analysis-and-meta-regression
#15
REVIEW
Ruma G Singh, Harry D Yoon, Landy M Wu, Jun Lu, Lindsay D Plank, Maxim S Petrov
OBJECTIVE: Growing evidence suggests that individuals with excessive fat in the pancreas are at an increased risk of chronic metabolic disorders. The aim was to systematically review studies on non-alcoholic fatty pancreas disease (NAFPD) with a view to determine its prevalence, associations with metabolic co-morbidities, and to suggest normal pancreatic fat percentage threshold. METHODS: Three electronic databases (MEDLINE, Scopus, and Embase) were queried. Studies in humans were eligible for inclusion if they provided data on NAFPD and/or pancreatic fat percentage...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28276827/direct-endoscopic-biopsy-for-subepithelial-tumor-larger-than-20%C3%A2-mm-after-removal-of-overlying-mucosa
#16
Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Su Jin Kim, Sun Hwi Hwang, Si Hak Lee
OBJECTIVE: An accurate diagnosis of a subepithelial tumor (SET) using endoscopic ultrasound (EUS) without tissue acquisition is difficult. Treatment plan for a SET may be influenced by endoscopic tissue diagnosis. We aimed to clarify the clinical outcomes of direct endoscopic biopsy for SET after removal of the overlying mucosa. METHODS: We evaluated the medical records of 15 patients. All patients underwent direct endoscopic biopsy for a SET larger than 20 mm (involving proper muscle layer) after removal of the overlying mucosa...
June 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28220958/contrast-enhanced-harmonic-endoscopic-ultrasonography-for-differential-diagnosis-of-submucosal-tumors-of-the-upper-gastrointestinal-tract
#17
Ken Kamata, Mamoru Takenaka, Masayuki Kitano, Shunsuke Omoto, Takeshi Miyata, Kosuke Minaga, Kentaro Yamao, Hajime Imai, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Takaaki Chikugo, Yasutaka Chiba, Haruhiko Imamoto, Takushi Yasuda, Andrea Lisotti, Pietro Fusaroli, Masatoshi Kudo
BACKGROUND AND AIMS: To evaluate contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) for the differential diagnosis of submucosal tumors (SMT) of the upper gastrointestinal tract. METHODS: Between June 2008 and May 2015, 157 consecutive patients with submucosal lesions of the upper gastrointestinal tract were evaluated by CH-EUS. This was a single-center retrospective analysis of prospectively collected data in a registry. The data from 73 patients who later underwent surgical resection were analyzed in this study...
February 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28187871/hyperamylasaemia-and-gastrointestinal-bleeding-as-the-first-manifestation-of-jejunal-ectopic-pancreas
#18
Iago Rodríguez-Lago, María Navajas, Margarita Durán, Amaia Martínez, Soraya Torres, Marta Aduna, Leire Etxegarai, José Luis Cabriada
No abstract text is available yet for this article.
February 7, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28162956/exercise-and-ectopic-fat-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#19
REVIEW
A Sabag, K L Way, S E Keating, R N Sultana, H T O'Connor, M K Baker, V H Chuter, J George, N A Johnson
Ectopic adipose tissue surrounding the intra-abdominal organs (visceral fat) and located in the liver, heart, pancreas and muscle, is linked to cardio-metabolic complications commonly experienced in type 2 diabetes. A systematic review and meta-analysis was performed to determine the effect of exercise on ectopic fat in adults with type 2 diabetes. Relevant databases were searched to February 2016. Included were randomised controlled studies, which implemented≥4 weeks of aerobic and/or resistance exercise and quantified ectopic fat via magnetic resonance imaging, computed tomography, proton magnetic resonance spectroscopy or muscle biopsy before and after intervention...
February 2, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28151472/calcb-splice-region-pathogenic-variants-leading-to-plasma-cell-neurotropic-enrichment-in-type-1-autoimmune-pancreatitis
#20
Qi-Cai Liu, Falin Chen, Chao-Yang Wu, Feng Gao, Ze-Hao Zhuang, Jin-Tong Chen, Bin Cai, Tianming Zhang, Ling Guo, Li-Qing Lin, Cheng-Fei Zhao, Xin-Hua Lin
Recently, we have demonstrated that PRSS1 mutations cause ectopic trypsinogen activation and thereby result in type 1 autoimmune pancreatitis (AIP). However, the molecules involved in inducing obliterative vasculitis and perineural inflammation in the pancreas are not well-described. The present study applied whole-exome sequencing (WES) to determine the underlying etiology and revealed novel missense splice region variants, CALCB c.88T>C (p.Ser30Pro) and IR [1]-mutants, in 2 of the 3 families and 2 of 26 unrelated patients with type 1 AIP...
February 2, 2017: Cell Death & Disease
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