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Hüseyin Ozan Çirkinoğlu, Mustafa Mert Bayer, Ulaş Sabahattin Gökay, Ali Serpengüzel, Belén Sotillo, Vibhav Bharadwaj, Roberta Ramponi, Shane Michael Eaton
We report on the coupling of whispering gallery modes in a 500-μm-radius silicon microsphere to a femtosecond-laser-inscribed glass optical waveguide. The shallow glass waveguide with a large mode field diameter in the near-infrared is written at a depth of 25 μm below the glass surface, resulting in a high excitation impact parameter of 525 μm for the microsphere. The excited whispering gallery modes of the silicon microsphere have quality factors of approximately 105 in the 90° elastic scattering and 0° transmission...
May 10, 2018: Applied Optics
Mazlum Şahin, Cihan Yücel, Eyüp Murat Kanber, Fatma Tuba İlal Mert, Burcu Bıçakhan
BACKGROUND: To present the surgical experience at a tertiary academic center of treating patients with traumatic arteriovenous fistulas (AVFs) who in whom endovascular treatment was contraindicated or in whom unsuccessful endovascular treatment had been performed. METHODS: A total of 27 patients with traumatic AVFs who underwent surgery between September 2014 and May 2016 were included. The site of injury, timing of surgery, and the surgical methods utilized were analyzed retrospectively...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Mert Simsek, Mehmet Citirik, Serdar Ozates, Dilara Ozkoyuncu
Purpose: This study evaluated the effect of intravitreal dexamethasone implant (IDI; Ozurdex) injection for treating macular edema in patients with branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO). Methods: This prospective study included 40 eyes of 40 patients with nonischemic BRVO and 31 eyes of 31 patients with nonischemic CRVO who received IDI injection as the first-line treatment for macular edema. The best-corrected visual acuity (BCVA) value before and after the treatment; intraocular pressure; optic coherence tomography findings; and all ocular examination findings, including central foveal thickness (CFT) measurement and fluorescein angiography findings, were evaluated for each patient...
June 2018: Indian Journal of Ophthalmology
Muhammet Karakavuk, Mehmet Aykur, Ayşegül Ünver, Mert Döşkaya
Travel is important in the spread of diseases, and the number of travelers is increasing daily. Therefore, the importance of the diseases that occur during or after travel is increasing. In underdeveloped countries in particular, parasitic diseases are epidemic or endemic, and these diseases lead to high numbers of deaths. People traveling from developed to underdeveloped countries have a higher risk of transmission of parasitic diseases during travel. Fifteen percent of the world's population lives in Africa...
May 21, 2018: Türkiye Parazitolojii Dergisi
Lena Haeberle, Katja Steiger, Anna Melissa Schlitter, Sami Alexander Safi, Wolfram Trudo Knoefel, Mert Erkan, Irene Esposito
BACKGROUND/OBJECTIVES: An abundant stromal reaction is a hallmark of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). The cells mainly responsible for the stromal reaction are activated pancreatic stellate cells (PSCs). Despite their crucial role, PSCs are not well characterized. PSCs share characteristics with the better-known hepatic stellate cells (HSCs). The aim of this study was a detailed analysis of PSCs in PDAC and CP. METHODS: Whole-slide specimens of CP (n = 12) and PDAC (n = 10) were studied by histochemistry and immunohistochemistry...
May 12, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Mert Ilhan, Zulfiqar Ali, Ikhlas A Khan, Esra Küpeli Akkol
A new isoflavane derivative, melilofficinaside together with seven other metabolites including coumarin, uridine, methyl-α-d-fructofuranoside, and flavonoid glucosides were isolated from the aerial parts of Melilotus officinalis (L.) Pall.
May 18, 2018: Natural Product Research
Mehmet C Mert, Peter Filzmoser, Gottfried Endel, Ingrid Wilbacher
Compositional data analysis refers to analyzing relative information, based on ratios between the variables in a data set. Data from epidemiology are usually treated as absolute information in an analysis. We outline the differences in both approaches for univariate and multivariate statistical analyses, using illustrative data sets from Austrian districts. Not only the results of the analyses can differ, but in particular the interpretation differs. It is demonstrated that the compositional data analysis approach leads to new and interesting insights...
June 2018: Statistical Methods in Medical Research
Sila Ulus, Cem Turam, Deniz Mutlu, Ipek Inal Kaleli, Mert Kocak, Umit Aksoy Ozcan
OBJECTIVES: Diagnosis of ventriculomegaly (VM) and identification of choroid plexus (CP) can be challenging with fetal magnetic resonance imaging (MRI). Our aim is to create an adjunct method for supporting the diagnosis of VM by investigating the CP-ventricular wall separation distance in fetuses with and without VM (nV) with fetal MRI. METHODS: T2-weighted fetal MRIs of 154 fetuses were retrospectively evaluated. The CP separation was defined as the distance between the medial wall of the dependent ventricle and distal tip of the CP glomus...
May 5, 2018: Brain & Development
Ümit Ertaş, Mert Ataol
Cleft lip and palate (CLP) patients have various problems with nasal anatomy beyond just oronasal separation. The alar base, concha, and septum are over impressed in these individuals. Additionally, skeletal class III deformity is seen. These conditions may limit nasal function. In our study, 15 unilateral patients with CLP older than 15 years (10 females, 5 males; mean age: 19.13) who had received surgery were included as the study group, and 15 participants with noncleft skeletal class III deformities were included as the control group (10 females, 5 males; mean age: 19...
January 1, 2018: Cleft Palate-craniofacial Journal
Murat Gok, Harun Kundi, Emrullah Kiziltunc, Mert Evlice, Mustafa Cetin, Muhammed Suleymanoglu, Alparslan Kurtul, Ender Ornek
BACKGROUND: The aim of this study was to investigate the relationship between prodromal angina (PA) with neutrophil-to-lymphocyte ratio (NLR) in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: The study group included 145 patients with STEMI who underwent emergency coronary angiography (CA) within 24hours of symptom onset. Data were collected regarding whether patients had experienced PA before acute myocardial infarction. Seventy-three patients (50...
April 18, 2018: Heart, Lung & Circulation
Mert Tuzer, Abdulkadir Yazıcı, Rüştü Türkay, Michael Boyman, Burak Acar
PURPOSE: To develop a medical ultrasound (US) simulation method using T1-weighted magnetic resonance images (MRI) as the input that offers a compromise between low-cost ray-based and high-cost realistic wave-based simulations. METHODS: The proposed method uses a novel multi-ray image formation approach with a virtual phased array transducer probe. A domain model is built from input MR images. Multiple virtual acoustic rays are emerged from each element of the linear transducer array...
May 4, 2018: International Journal of Computer Assisted Radiology and Surgery
Bülent Özlek, Eda Özlek, Oğuzhan Çelik, Cem Çil, Volkan Doğan, Mehmet Tekinalp, Hicaz Zencirkıran Ağuş, Serkan Kahraman, Altuğ Ösken, İbrahim Rencüzoğulları, Veysel Ozan Tanık, Lütfü Bekar, Mustafa Ozan Çakır, Bedri Caner Kaya, Hakan Tibilli, Yunus Çelik, Özcan Başaran, Kadir Uğur Mert, Samet Sevinç, Erkan Demirci, Engin Dondurmacı, Murat Biteker
OBJECTIVE: Although almost half of chronic heart failure (HF) patients have mid-range (HFmrEF) and preserved left-ventricular ejection fraction (HFpEF), no studies have been carried out with these patients in our country. This study aims to determine the demographic characteristics and current status of the clinical background of HFmrEF and HFpEF patients in a multicenter trial. METHODS: A comPrehensive, ObservationaL registry of heart faiLure with mid range and preserved ejectiON fraction (APOLLON) trial will be an observational, multicenter, and noninterventional study conducted in Turkey...
May 2018: Anatolian Journal of Cardiology
Michael A Trembley, Pearl Quijada, Esperanza Agullo-Pascual, Kevin M Tylock, Mert Colpan, Ronald A Dirkx, Jason R Myers, Deanne M Mickelsen, Karen de Mesy Bentley, Eli Rothenberg, Christine S Moravec, Jeffrey D Alexis, Carol C Gregorio, Robert T Dirksen, Mario Delmar, Eric M Small
Background -Hypertrophic cardiomyocyte (CM) growth and dysfunction accompanies various forms of heart disease. The mechanisms responsible for transcriptional changes that impact cardiac physiology and the transition to heart failure (HF) are not well understood. The intercalated disc (ID) is a specialized intercellular junction coupling CM electrical activity and force transmission, and is gaining attention as a mechanosensitive signaling hub and hotspot for causative mutations in cardiomyopathy. Methods -Transmission electron microscopy, confocal microscopy, and single-molecule localization microscopy (SMLM) were used to examine changes in ID structure and protein localization in the murine and human heart...
May 1, 2018: Circulation
Mert Y Sengul, Clive A Randall, Adri C T van Duin
The intermolecular structure formation in liquid and supercritical acetic acid-water mixtures was investigated using ReaxFF-based molecular dynamics simulations. The microscopic structures of acetic acid-water mixtures with different acetic acid mole fractions (1.0 ≥ xHAc ≥ 0.2) at ambient and critical conditions were examined. The potential energy surface associated with the dissociation of acetic acid molecules was calculated using a metadynamics procedure to optimize the dissociation energy of ReaxFF potential...
April 28, 2018: Journal of Chemical Physics
Myriam Tobollik, Dietrich Plaß, Nadine Steckling, Hanna Mertes, Thomas Myck, Thomas Ziese, Dirk Wintermeyer, Claudia Hornberg
BACKGROUND: Environmental risk factors can have a substantial impact on population health. With the environmental burden of disease (EBD) approach, the health losses attributable to environmental risk factors can be quantified using disability-adjusted life years (DALY). OBJECTIVES: The aim of this article is to present and discuss available EBD estimates with a focus on Germany. MATERIALS: Using current EBD studies, the share of the burden of disease attributable to environmental risk factors globally and DALYs for Germany are presented...
April 26, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Yelda Buyru Özkurt, Sezen Akkaya, Sibel Aksoy, Mert Hakan Şimşek
PURPOSE: To compare the effects of intravitreal ranibizumab injection and yellow (577 nm) subthreshold micropulse laser treatment in patients with macular edema following non-ischemic branch retinal vein occlusion. METHODS: The medical records of 51 patients who underwent intravitreal ranibizumab (0.5 mg) injection or subthreshold micropulse laser for the treatment of macular edema due to branch retinal vein occlusion were retrospectively reviewed. Subthreshold micropulse laser was administered with a 10% duty cycle, 100 μm spot diameter, 200 ms exposure time...
April 1, 2018: European Journal of Ophthalmology
Bilge Debeleç-Bütüner, Mert Burak Öztürk, Özgür Tağ, İsmail Hakkı Akgün, Günay Yetik-Anacak, Erdal Bedir, Kemal Sami Korkmaz
Chronic inflammation is associated to 25% of cancer cases according to epidemiological data. Therefore, inhibition of inflammation-induced carcinogenesis can be an efficient therapeutic approach for cancer chemoprevention in drug development studies. It is also determined that anti-inflammatory drugs reduce cancer incidence. Cell culture-based in vitro screening methods are used as a fast and efficient method to investigate the biological activities of the biomolecules. In addition, saponins are molecules that are isolated from natural sources and are known to have potential for tumor inhibition...
April 17, 2018: Steroids
Rikuan Zheng, Shimei Wu, Ning Ma, Chaomin Sun
Mercury-mediated toxicity remains one of the greatest barriers against microbial survival, even though bacterial resistance to mercury compounds can occur. However, the genetic and physiological adaptations of bacteria to mercury stress still remains unclear. Here, we show that the marine bacterium Pseudomonas stutzeri 273 is resistant to 50 μM Hg2+ and removes up to 94% Hg2+ from culture. Using gene homologous recombination and complementation, we show that genes encoding Hg2+ -transport proteins MerT, MerP, the mercuric reductase MerA and the regulatory protein MerD are essential for bacterial mercuric resistance when challenged with Hg2+ ...
2018: Frontiers in Microbiology
Merdan Serin, Dincer Altinel, Cem Leblebici, Burcu Biltekin, Mert Celikten, Fatih Irmak, Sevgi Kurt Yazar
PURPOSE: To investigate the effect of subcutaneous sildenafil on random flap survival. METHODS: Fourteen Wistar rats, which were divided in to two groups, were used for this experimental study. Rats in the sildenafil group received subcutaneous sildenafil injections daily for seven days before flap elevation. At the end of the treatment period, 9x3 cm dorsal skin flaps were elevated and reinserted back into their place in all of the animals. Necrotic and whole flaps areas were recorded on graph papers...
March 2018: Acta Cirúrgica Brasileira
Muhammet Karakavuk, Duygu Aldemir, Aurélien Mercier, Esra Atalay Şahar, Hüseyin Can, Jean-Benjamin Murat, Ömer Döndüren, Şengül Can, Hüseyin Gökhan Özdemir, Aysu Değirmenci Döşkaya, Bayram Pektaş, Marie-Laure Dardé, Adnan Yüksel Gürüz, Mert Döşkaya
Toxoplasma gondii is a protozoon parasite that causes congenital toxoplasmosis, as well as other serious clinical presentations, in immune compromised humans. Analyses of the prevalence and genotyping of strains from the definitive host and intermediate hosts will help to understanding the circulation of the different strains and elucidating the role of the genotype(s) in human toxoplasmosis. Turkey has a specific geographic location bridging Africa, Europe, and Asia. We hypothesized that T. gondii strains may have been transferred to Turkey from these continents via migratory birds or vice versa...
2018: PloS One
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