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https://www.readbyqxmd.com/read/29137633/bi-directional-exosome-driven-intercommunication-between-the-hepatic-niche-and-cancer-cells
#1
Nikolina Dioufa, Amanda M Clark, Bo Ma, Colin H Beckwitt, Alan Wells
BACKGROUND: Our understanding of the multiple roles exosomes play during tumor progression is still very poor and the contribution of the normal tissue derived exosomes in distant seeding and tumor outgrowth has also not been widely appreciated. METHODS: Using our all-human liver microphysiological system (MPS) platform as a model to closely recapitulate the early metastatic events, we isolated exosomes from both tumor cells and liver microenvironment. RESULTS: We observed that while priming of the hepatic niche (HepN) with MDA-231 breast cancer derived exosomes facilitated seeding of the cancer cells in the liver, subsequent tumor outgrowth was diminished; this was consistent with increased entry into dormancy...
November 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29135685/olivocochlear-efferent-activity-is-associated-with-the-slope-of-the-psychometric-function-of-speech-recognition-in-noise
#2
Ian B Mertes, Erin C Wilbanks, Marjorie R Leek
OBJECTIVES: The medial olivocochlear (MOC) efferent system can modify cochlear function to improve sound detection in noise, but its role in speech perception in noise is unclear. The purpose of this study was to determine the association between MOC efferent activity and performance on two speech-in-noise tasks at two signal-to-noise ratios (SNRs). It was hypothesized that efferent activity would be more strongly correlated with performance at the more challenging SNR, relative to performance at the less challenging SNR...
November 9, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29134819/web-based-intervention-to-improve-implantable-cardioverter-defibrillator-patients-shock-related-anxiety-and-quality-of-life-a-randomized-controlled-trial
#3
Tuğba Yardımcı, Hatice Mert
In spite of its effectiveness, implantable cardioverter defibrillator (ICD) patients face psychological problems such as shock-related anxiety due to device shocks. The aim of this study was to evaluate whether a web-based intervention program for ICD patients would reduce shock-related anxiety and improve quality of life compared with usual care. This was a randomized controlled trial study including a total of 76 patients. Data were collected using Turkish versions of the Florida Shock Anxiety Scale and Short Form Health Survey (SF-36) at 0 (baseline), 3, and 6 months...
November 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/29134007/taxonomic-notes-on-two-sibling-species-of-metellina-from-asia-araneae-tetragnathidae
#4
Recep Sulhi Özkütük, Yuri M Marusik, Kadir Boğaç Kunt, Mert Elverici
Two sibling species, Metellina orientalis (Spassky, 1932) and M. kirgisica (Bakhvalov, 1974), occurring in the Middle East and Central Asia are redescribed and their distributions mapped. The previously unknown male of M. kirgisica is described for the first time. Stridulatory files on male chelicera of Metellina are also documented for the first time. The occurrence of M. kirgisica in Azerbaijan and Tajikistan and the presence of M. orientalis in Turkey are confirmed.
2017: ZooKeys
https://www.readbyqxmd.com/read/29132778/discourse-coalitions-in-swiss-waste-management-gridlock-or-winds-of-change
#5
Mert Duygan, Michael Stauffacher, Grégoire Meylan
As a complex socio-technical system, waste management is crucially important for the sustainable management of material and energy flows. Transition to better performing waste management systems requires not only determining what needs to be changed but also finding out how this change can be realized. Without understanding the political context, insights from decision support tools such as life cycle assessment (LCA) are likely to be lost in translation to decision and policy making. This study strives to provide a first insight into the political context and address the opportunities and barriers pertinent to initiating a change in Swiss waste management...
November 10, 2017: Waste Management
https://www.readbyqxmd.com/read/29131660/biomechanical-and-morphometric-properties-of-long-flexor-tendons-of-the-toes-a-cadaver-study
#6
Orhan Beger, Gamze Tumentemür, Coşar Uzun, Elif Nedret Keskinöz, Özlem Elvan, Deniz Uzmansel, Mert Keskinbora, Nurten Erdal, Bahar Taşdelen, Zeliha Kurtoğlu
METHODS: RESULTS: CONCLUSIONS.
November 13, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29129390/clinical-significance-of-enlarged-cardiophrenic-lymph-nodes-in-advanced-ovarian-cancer-implications-for-survival
#7
Ismail Mert, Amanika Kumar, Shannon P Sheedy, Amy L Weaver, Michaela E McGree, Bohyun Kim, William A Cliby
OBJECTIVE: Advanced ovarian cancer (OC) commonly spreads to cardiophrenic lymph nodes (CPLNs), and is often visible on preoperative imaging. We investigated the prognostic significance of abnormal CPLNs in OC detected by preoperative CT scans using three different definitions. METHODS: Patients undergoing primary debulking surgery for stage IIIC/IV with residual disease (RD) ≤1.0cm and a preoperative abdominopelvic CT scan available were included. Scans were reviewed by two blinded radiologists...
November 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29124343/anatomical-landmarks-of-mandibular-interforaminal-region-related-to-dental-implant-placement-with-3d-cbct-comparison-between-edentulous-and-dental-mandibles
#8
Elif Sener, Erinc Onem, Gulcan Coskun Akar, Figen Govsa, Mehmet Asim Ozer, Yelda Pinar, Ali Mert, B Guniz Baksi Sen
BACKGROUND: Anterior mandibular (interforaminal) region is important in implant applications as it serves a basis for neurovascular bedding and holds the prosthesis for patients. Treatment planning for dental implant patients is often complicated by the unknown extent of the anterior loop of the neurovascular bundle. Anatomical structures including mandibular incisive canal (MIC) and lingual foramen (LF) should also be examined as part of the detailed analysis for their neurovascular structures...
November 9, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29117609/-in-vitro-evaluation-of-the-optical-quality-of-segmental-refractive-multifocal-intraocular-lenses
#9
Timur Mert Yildirim, Gerd Uwe Auffarth, Tamer Tandogan, Stephanie Liebing, Grzegorz Labuz, Chul Young Choi, Ramin Khoramnia
Objectives In customised patient care, it is important to know the optical quality of different intraocular lenses (IOL). In this study, the optical quality of three segmental intraocular lenses were compared. Materials and Methods The LENTIS Comfort LS-313 MF15, LENTIS Mplus X LS-313 MF30 and LENTIS High Add IOL LS-313 MF80 (Oculentis, Berlin, Germany) with a far power of + 21 D were analysed at the optical bench OptiSpheric IOL PRO (Trioptics GmbH, Wedel, Germany). The lenses have almost the same optical design but differ in the power of the near segment...
November 8, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29117296/polygenic-risk-of-spasmodic-dysphonia-is-associated-with-vulnerable-sensorimotor-connectivity
#10
Gregory Garbès Putzel, Giovanni Battistella, Anna F Rumbach, Laurie J Ozelius, Mert R Sabuncu, Kristina Simonyan
Spasmodic dysphonia (SD), or laryngeal dystonia, is an isolated task-specific dystonia of unknown causes and pathophysiology that selectively affects speech production. Using next-generation whole-exome sequencing in SD patients, we computed polygenic risk score from 1804 genetic markers based on a genome-wide association study in another form of similar task-specific focal dystonia, musician's dystonia. We further examined the associations between the polygenic risk score, resting-state functional connectivity abnormalities within the sensorimotor network, and SD clinical characteristics...
November 19, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/29115935/microrna-expression-patterns-in-canine-mammary-cancer-show-significant-differences-between-metastatic-and-non-metastatic-tumours
#11
Malgorzata Bulkowska, Agata Rybicka, Kerem Mert Senses, Katarzyna Ulewicz, Katarzyna Witt, Joanna Szymanska, Bartlomiej Taciak, Robert Klopfleisch, Eva Hellmén, Izabella Dolka, Ali O Gure, Joanna Mucha, Mariusz Mikow, Slawomir Gizinski, Magdalena Krol
BACKGROUND: MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. Several common oncogenic microRNAs have been found for canine mammary cancer and human breast cancer. On account of this, large-scale profiling of microRNA expression in canine mammary cancer seems to be important for both dogs and humans. METHODS: Expression profiles of 317 microRNAs in 146 canine mammary tumours of different histological type, malignancy grade and clinical history (presence/absence of metastases) and in 25 control samples were evaluated...
November 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29114421/vocal-cord-paralysis-following-endotracheal-intubation
#12
Hamdi Taşlı, Umut Kara, Mert Cemal Gökgöz, Ümit Aydın
No abstract text is available yet for this article.
October 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29113641/a-simple-independent-prognostic-electrocardiography-parameter-in-first-acute-anterior-myocardial-infarction-precordial-total-q-wave-precordial-total-r-wave
#13
Mert İlker Hayıroğlu, Ahmet Okan Uzun, Muhammed Keskin, Edibe Betül Börklü, Ahmet İlker Tekkeşin, Ceyhan Türkkan, Ömer Kozan
BACKGROUND: We investigated the prognostic value of precordial total Q wave amplitude/precordial total R wave amplitude ratio (Q/R) in patients with first acute anterior MI treated with primary percutaneous coronary intervention (PPCI). METHODS: We evaluated the in-hospital prognostic impact of Q/R on 354 patients with first acute anterior MI. Patients were stratified by tertiles of admission Q/R, clinical outcomes were compared between those groups. RESULTS: In-hospital univariate analysis revealed notably higher rates of in-hospital death for patients in tertile 3, as compared to patients in tertile 1 (OR 9...
September 27, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29105726/complications-of-2-level-dynamic-stabilization
#14
Mert Ciplak, Tuncer Suzer, Salim Senturk, Onur Yaman, Mehdi Sasani, Tunc Oktenoglu, Atilla Yilmaz, Deniz Ufuk Erbulut, Ali Fahir Özer
AIM: A retrospective chart and a radiographic review. Evaluation of postoperative complications, clinical improvements and radiological parameters in patients who underwent surgery using a dynamic system for 2-level lumbar stabilization. We aimed to investigate the postoperative complications, such as screw loosening, screw breakage and ASD, in patients who underwent surgery with 2-level dynamic stabilization systems. MATERIALS AND METHODS: Dynamic lumbar systems enable the stabilization of unstable degenerative spines, while preventing fusion-related complications, such as adjacent segment disease(ASD) and pseudarthrosis...
September 25, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29103500/ratiometric-fluorescence-detection-of-an-anthrax-biomarker-with-eu-3-chelated-chitosan-biopolymers
#15
Mert Donmez, Huseyin Avni Oktem, M Deniz Yilmaz
A novel chitosan-based ratiometric fluorescent probe incorporating an EDTA-Eu(3+) complex as the sensing unit and fluorescein dye as the internal standard was designed to detect dipicolinic acid (DPA) as an anthrax biomarker with high sensitivity and selectivity. The fluorescence intensity of fluorescein dye attached to the chitosan backbone remains constant as an internal reference, while the Eu(3+) emission increased linearly upon the consecutive addition of DPA. The selectivity studies were performed by adding different competitive aromatic ligands to the sensing environment and no signifacant fluorescence response was observed...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29096583/comparison-of-svcam-1-and-sicam-1-levels-in-maternal-serum-and-vaginal-secretion-between-pregnant-women-with-preterm-prelabour-ruptures-of-membranes-and-healthy-pregnant-women
#16
Sibel Sak, Mert Barut, Adnan Incebiyik, Elif Ağaçayak, Adnan Kirmit, Ismail Koyuncu, Muhammet Sak
OBJECTIVE: The study aims to evaluate the maternal serum and the vaginal fluid levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecular (sICAM-1) in pregnant women complicated by preterm prelabour ruptures of membranes (PPROM). MATERIALS AND METHODS: The prospective case control study included 34 pregnant women with PPROM and 34 healthy pregnant women. Patients with additional diseases, a smoking habit and vaginal bleeding, as well as those using antibiotics, during the study period were not included in the study...
November 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29096564/management-of-peripartum-hysterectomies-performed-on-patients-with-placenta-percreta-in-a-tertiary-central-hospital
#17
Sibel Sak, Mert Barut, Adnan Incebiyik, Hacer Uyanikoglu, Nese Hilali, Muhammet Sak
OBJECTIVE: The main objective of this study is to analyse the circumstances and management of peripartum hysterectomies performed on patients with placenta percreta. METHODS: This study included 37 patients who were diagnosed with placenta percreta, a condition in which the placenta invades the uterine wall, and who therefore underwent a peripartum hysterectomy. Their demographic characteristics, history of past caesareans, uterine surgery and curettage, duration of hospitalization, admission to an intensive care unit, neonatal outcomes, skin and uterus incision type, hypogastric artery ligation (HAL), complications, quantities of transfused ES (erythrocyte suspensions), and FFP (fresh frozen plasma), maternal morbidity and mortality and postoperative pathology results were retrospectively reviewed...
November 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29080077/effects-of-single-and-double-layered-resorbable-membranes-and-platelet-rich-fibrin-on-bone-healing
#18
Mert Tayşi, Berkem Atalay, Burak Çankaya, Sami Yıldırım
OBJECTIVES: Research has been ongoing on achieving optimum bone healing in the reconstruction of bone loss. Clinically, soft tissue migration into the already existing bone defects is the leading cause of unfavourable bone healing. Platelet-rich fibrin, a recent material that is used to promote bone healing, was compared with single- and double-layered resorbable collagen membranes to determine whether a healing protocol which increases patient comfort is possible. MATERIALS AND METHODS: Sixty adult female Sprague-Dawley rats were used...
October 27, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29073985/cost-evaluation-of-inhaler-therapies-used-in-respiratory-diseases-1998-2015-period-in-turkey
#19
Banu Bayar, Nurcan Uman Kutkan, Esra Şafak Yılmaz, Çiğdem Tolun, Engin Doğan, Enver Kağan Atikeler, Elif Hilal Vural, Salih Babacan, Nurgül Karabekmez, Aslıhan Beyan, İsmail Mert Vural, İpek Kıvılcım Oğuzülgen, Güven Bektemür, Simten Malhan, Rabia Kahveci, Sedat Altın, Ali Alkan, Hakan Eroğlu, Hakkı Gürsöz
BACKGROUND: With the rise in life expectancy, the burden of chronic diseases, including obstructive pulmonary diseases, has increased throughout the world. OBJECTIVES: To evaluate the sales trends of inhaler pharmaceuticals. METHODS: The changes in box sales and sales amounts (in Turkish lira) of inhaler pharmaceuticals during the period 1998 to 2015 were examined and sales were projected for the next 3 years. Pharmaceuticals were classified according to form and pharmacological groups...
September 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29065344/quantitative-analysis-of-the-amygdala-thalamus-and-hippocampus-on-magnetic-resonance-images-in-paediatric-bipolar-disorders-and-compared-with-the-children-of-bipolar-parents-and-healthy-control
#20
Seher Akbaş, Mert Nahir, Mennan Ece Pirzirenli, Cihat Dündar, Meltem Ceyhan, Gökhan Sarısoy, Bünyamin Şahin
MR imaging studies in paediatric bipolar disorder have particularly focused on the amygdala and hippocampus, subcortical structures, and to a lesser extent on the thalamus. The purpose of this study was to perform structural analysis of the regions of interest (ROI) associated with mood regulation. In this study 18 children (between the ages of 12-18) were matched according to their age and sex and were divided into three groups. These were: a paediatric bipolar disorder group, risk group and a healthy control group...
December 30, 2017: Psychiatry Research
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