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Adnan Kaya, Mert İlker Hayıroğlu, Muhammed Keskin, Ahmet Öz, Berat Arıkan Aydın
Biventricular thrombi secondary to anterior myocardial infarction is very rare. We present a patient with giant biventricular thrombi subsequent to an old anterior wall myocardial infarction, and devastating consequences, including acute pulmonary artery and femoral artery embolism. We introduce a unique case report with demonstrative and illustrative images.
September 2016: Indian Heart Journal
Fabio Bozzi, Silvia Brich, Gian Paolo Dagrada, Tiziana Negri, Elena Conca, Barbara Cortelazzi, Antonino Belfiore, Federica Perrone, Ambra Vittoria Gualeni, Annunziata Gloghini, Antonello Cabras, Monica Brenca, Roberta Maestro, Nadia Zaffaroni, Paolo Casali, Rossella Bertulli, Marcello Deraco, Silvana Pilotti
The aim of this study was to reconsider the biological characteristics of epithelioid malignant peritoneal mesothelioma (E-MpM) in the light of new concepts about epithelial mesenchymal transition and mesenchymal epithelial reverse transition (EMT/MErT) and the role of epigenetic reprogramming in this context. To this end we profiled surgical specimens and derived cells cultures by a number of complementary approaches i.e. immunohistochemistry, immunofluorescence, in situ hybridization, biochemistry, pluripotent stem cell arrays, treatments with cytokines, growth factors and specific inhibitors...
September 26, 2016: Oncotarget
Xiuming Zhang, Elizabeth C Mormino, Nanbo Sun, Reisa A Sperling, Mert R Sabuncu, B T Thomas Yeo
We used a data-driven Bayesian model to automatically identify distinct latent factors of overlapping atrophy patterns from voxelwise structural MRIs of late-onset Alzheimer's disease (AD) dementia patients. Our approach estimated the extent to which multiple distinct atrophy patterns were expressed within each participant rather than assuming that each participant expressed a single atrophy factor. The model revealed a temporal atrophy factor (medial temporal cortex, hippocampus, and amygdala), a subcortical atrophy factor (striatum, thalamus, and cerebellum), and a cortical atrophy factor (frontal, parietal, lateral temporal, and lateral occipital cortices)...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
Burak Karadag, Onur Erol, Ozgur Ozdemir, Aysel Uysal, Ahmet Sukru Alparslan, Cemil Gurses, Mert Koroglu
Uterine arteriovenous malformation (AVM) is defined as abnormal and nonfunctional connections between the uterine arteries and veins. Although the patients typically present with vaginal bleeding, some patients may experience life-threatening massive bleeding in some circumstances. The treatment of choice depends on the symptoms, age, desire for future fertility, and localization and size of the lesion; however, embolization of the uterine artery is the first choice in symptomatic AVM in patients at reproductive age with expectations of future fertility...
2016: Case Reports in Obstetrics and Gynecology
Bulent Kantarcioglu, Huseyin Saffet Bekoz, Fatih Erkam Olgun, Beytullah Cakal, Burak Arkan, Halil Turkoglu, Ali Mert, Deniz Sargin
In chronic myeloid leukemia (CML), the occurrence of blastic transformation is rare. Treatment outcome is generally poor. Allogeneic stem cell transplantation (allo-SCT) is the only potentially curative treatment option for advanced-phase CML. Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates are associated with high morbidity and mortality rates, particularly in patients with haematological malignancies. Infection and colonization by these multiresistant bacteria may represent a challenge in SCT recipients for the management of post-transplantation complications, as well as for the eligibility to receive a transplant in patients who acquire the pathogen prior to the procedure...
October 2016: Molecular and Clinical Oncology
Dilek Soydemir, Seyda Seren Intepeler, Hatice Mert
The purpose of the study was to determine what barriers to error reporting exist for physicians and nurses. The study, of descriptive qualitative design, was conducted with physicians and nurses working at a training and research hospital. In-depth interviews were held with eight physicians and 15 nurses, a total of 23 participants. Physicians and nurses do not choose to report medical errors that they experience or witness. When barriers to error reporting were examined, it was seen that there were four main themes involved: fear, the attitude of administration, barriers related to the system, and the employees' perceptions of error...
September 30, 2016: Western Journal of Nursing Research
Edip Güvenç Çekiç, Özcan Başaran, Nesrin Filiz Başaran, Onur Elmas, Volkan Doğan, Gurbet Özge Mert, Kadir Uğur Mert, Ibrahim Altun, Fatih Akın, Murat Biteker
BACKGROUND AND AIM: Decreased vascular reactivity in atherosclerosis was previously shown. In our study, it was aimed to demonstrate the decreased vascular functions in both microvascular and macrovascular tissues and to estimate any correlation between them. METHODS: Twenty-five control outpatients with no coronary artery disease (CAD) history and 26 outpatients with CAD history were enrolled in the study. Local cutaneous post-occlusive reactive hyperemia (PORH) responses after three minutes of brachial occlusion with a pneumatic cuff were recorded noninvasively by a Perimed Periflux 5010 laser Doppler flow system...
September 28, 2016: Microvascular Research
Mehmet Karakuş, Yasemen Sarıkaya, Gizem Oğuz, Mert Doğan, Gökhan Ergan, Filiz Günay, Özge Erişöz Kasap, Yusuf Özbel, Bülent Alten
BACKGROUND: Leishmania is a group of parasitic flagellated protozoons, which are transmitted by female sand flies and produces health problems in humans and also in wild and domestic animals. So far, 25 Phlebotomus and 4 Sergentomyia species were recorded in Turkey including proven or possible vectors of Leishmania spp. As no single insecticide susceptibility test was conducted targeting the sand flies in Turkey, we aimed to determine the diagnostic dose against two commonly used synthetic pyrethroids (deltamethrin and permethrin) in a hyperendemic area for leishmaniasis...
September 29, 2016: Parasites & Vectors
Erguvan Tugba Ozel-Kizil, Ahmet Kokurcan, Umut Mert Aksoy, Bilgen Bicer Kanat, Direnc Sakarya, Gulbahar Bastug, Burcin Colak, Umut Altunoz, Sevinc Kirici, Hatice Demirbas, Bedriye Oncu
Patients with Attention Deficit Hyperactivity Disorder (ADHD) suffer not only from inability to focus but also from inability to shift attention for events that trigger their interests. This phenomenon is called "hyperfocusing". Previous literature about hyperfocusing is scarce and relies mainly on case reports. The study aimed to investigate and compare the severity of hyperfocusing in adult ADHD with and without psycho-stimulant use. ADHD (DSM-IV-TR) patients either psycho-stimulant naive (n=53) or on psycho-stimulants (n=79) from two ADHD clinics were recruited...
September 25, 2016: Research in Developmental Disabilities
Paul-Michel Mertes, Erik Florvaag
No abstract text is available yet for this article.
September 2016: La Presse Médicale
Irina Heid, Katja Steiger, Marija Trajkovic-Arsic, Marcus Settles, Manuela R Eßwein, Mert Erkan, Jorg Kleeff, Carsten Jäger, Helmut Friess, Bernhard Haller, Andreas Steingötter, Roland M Schmid, Markus Schwaiger, Ernst J Rummeny, Irene Esposito, Jens T Siveke, Rickmer Braren
PURPOSE: Tumor heterogeneity is a hallmark of pancreatic ductal adenocarcinoma (PDAC). It determines tumor biology including tumor cellularity (i.e. amount of neoplastic cells and arrangement into clusters), which is related to the proliferative capacity and differentiation and the degree of desmoplasia among others. Given the close relation of tumor differentiation with differences in progression and therapy response or e.g. the recently reported protective role of tumor stroma, we aimed at the non-invasive detection of PDAC groups, relevant for future personalized approaches...
September 23, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Mert Celikin, David Barba, Binod Bastola, Andreas Ruediger, Federico Rosei
The effect of annealing cycle on regeneration efficiency was investigated through isothermal treatments between 700 and 1000°C. We determined an inverse relationship between the recovery rate of the peak reflectivity and temperature. A regeneration efficiency of 85.2% and long-term stability at 1000°C for 500 hours were achieved via a slow regeneration process. Thermal sensors developed by isothermal regeneration were determined to be reliable up to 1000°C (±2 °C). Experimental findings suggest the involvement of both diffusion related phenomena and stress variation through densification of the fiber core in type-I FBG during the thermal regeneration process...
September 19, 2016: Optics Express
Gülçin Saltan, Ipek Süntar, Serkan Ozbilgin, Mert Ilhan, M Ayşe Demirel, Burçin Ergene Oz, Hikmet Keleş, Esra Küpeli Akkol
ETHNOPHARMACOLOGICAL RELEVANCE: Endometriosis is a gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. The fruits of Viburnum opulus L. have been used to treat gynecological disorders including primary and secondary dysmenorrhea and ovarian cysts. MATERIALS AND METHODS: Air-dried and powdered fruits of V. opulus were extracted sequentially with n-hexane, ethyl acetate (EtOAc), and methanol (MeOH), respectively for four days...
September 16, 2016: Journal of Ethnopharmacology
Nilay Boztas, Sermin Oztekin, Sevda Ozkardes, Mert Akan, Sule Ozbilgin, Ayse Baytok
OBJECTIVE: We compared the effects of three different doses of remifentanil infusion, which were performed for the induction of anesthesia in elder patients, on cardiovascular response. RESEARCH DESIGN AND METHODS: The present study was designed as a randomized, prospective and double-blind study. A total of 90 ASA I-II patients over the age of 65 years were enrolled. The patients were randomly (by lot) assigned to receive one of the three doses of remifentanil infusion (0...
October 17, 2016: Current Medical Research and Opinion
Bo Kong, Philipp Bruns, Nora A Behler, Ligong Chang, Anna Melissa Schlitter, Jing Cao, Andreas Gewies, Jürgen Ruland, Sina Fritzsche, Nataliya Valkovskaya, Ziying Jian, Ivonne Regel, Susanne Raulefs, Martin Irmler, Johannes Beckers, Helmut Friess, Mert Erkan, Nikola S Mueller, Susanne Roth, Thilo Hackert, Irene Esposito, Fabian J Theis, Jörg Kleeff, Christoph W Michalski
OBJECTIVE: The initial steps of pancreatic regeneration versus carcinogenesis are insufficiently understood. Although a combination of oncogenic Kras and inflammation has been shown to induce malignancy, molecular networks of early carcinogenesis remain poorly defined. DESIGN: We compared early events during inflammation, regeneration and carcinogenesis on histological and transcriptional levels with a high temporal resolution using a well-established mouse model of pancreatitis and of inflammation-accelerated Kras(G12D)-driven pancreatic ductal adenocarcinoma...
September 19, 2016: Gut
Ahmet Ilker Tekkesin, Göksel Çinier, Yasin Cakilli, Mert İlker Hayıroğlu, Ahmet Taha Alper
BACKGROUND: Interatrial block which is defined as P wave duration longer than 120 milliseconds is underappreciated but highly prevalent electrocardiographic abnormality and associated with atrial tachyarrhythmias and ischemic stroke. Impaired left atrial mechanics and atrial fibrillation are potential mechanisms contributing to the embolic events associated with interatrial block. Detection of atrial high rate episodes by cardiac implantable electronic devices provides clinicians to diagnose asymptomatic atrial fibrillation...
September 8, 2016: Journal of Electrocardiology
H Gouezec, I Lerenard, S Jan, E Bajeux, P Renaudier, P M Mertes
PURPOSE OF THE STUDY: The goal of this study is to assess the physician's management of patients who refuse blood transfusion. MATERIAL AND METHODS: A questionnaire to assess the experience, the acceptance or refusal and the operating methods in case of vital risk has been realized and circulated at a national scale. RESULTS: A total of 793 questionnaires were sent back and analysed according to 3 different categories: anesthesiologists, physicians and surgeons...
September 12, 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
Tarik Ozmen, Mert Aydogmus
The aim of the present study was to investigate effect of core strength training (CST) on core endurance, dynamic balance and agility in adolescent badminton players. Twenty adolescent (age = 10.8 ± 0.3 years; height = 140.6 ± 4.4 cm, weight = 33.9 ± 5.8 kg) badminton players were randomly divided into two groups as training group (TG) and control (CG) group. All subjects were evaluated with Star Excursion Balance Test (SEBT), Illinois Agility Test, and the core endurance tests. The TG completed CST twice a week, for 6 weeks...
July 2016: Journal of Bodywork and Movement Therapies
Thomas Regnath, Thomas Mertes, Ralf Ignatius
Increasing antimicrobial resistance of Neisseria gonorrhoeae, particularly to third-generation cephalosporins, has been reported in many countries. We examined the susceptibility (determined by Etest and evaluated using the breakpoints of the European Committee on Antimicrobial Susceptibility Testing) of 434 N. gonorrhoeae isolates collected from 107 female and 327 male patients in Stuttgart, south-west Germany, between 2004 and 2015. During the study period, high proportions of isolates were resistant to ciprofloxacin (70...
September 8, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Yasemin Cag, Derya Ozturk-Engin, Serap Gencer, Rodrigo Hasbun, Gonul Sengoz, Alexandru Crisan, Nurgul Ceran, Branislava Savic, Kadriye Yasar, Filiz Pehlivanoglu, Gamze Kilicoglu, Hulya Tireli, Ayse S Inal, Rok Civljak, Recep Tekin, Nazif Elaldi, Aysegul Ulu-Kilic, Muge Ozguler, Mustafa Namiduru, Mustafa Sunbul, Oguz R Sipahi, Olga Dulovic, Selma Alabay, Ayhan Akbulut, Alper Sener, Botond Lakatos, Katell Andre, Mucahit Yemisen, Serkan Oncu, Mihai Nechifor, Ozcan Deveci, Seniha Senbayrak, Asuman Inan, Gorana Dragovac, Hanefi C G L, Gurkan Mert, Oral Oncul, Bahar Kandemir, Serpil Erol, Canan Agalar, Hakan Erdem
AIMS: There is no report on the factors affecting the resolution of symptoms related to meningitis during treatment of tuberculous meningitis (TBM). Thus, we examined the factors associated with early therapeutic responses. MATERIALS AND METHODS: This multicenter study included 507 patients with microbiologically confirmed TBM. However, 94 patients eligible for the analysis were included in this study from 24 centers. Six out of 94 patients died and the statistical analysis was performed with 88 survivors...
September 2016: Neurology India
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