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https://www.readbyqxmd.com/read/29023763/cps49-induced-neurotoxicity-does-not-cause-limb-patterning-anomalies-in-developing-chicken-embryos
#1
Chris Mahony, Scott McMenemy, Alexandra J Rafipay, Shaunna-Leigh Beedie, Lucas Rosa Fraga, Michael Gütschow, William D Figg, Lynda Erskine, Neil Vargesson
Thalidomide notoriously caused severe birth defects, particularly to the limbs, in those exposed in utero following maternal use of the drug to treat morning sickness. How the drug caused these birth defects remains unclear. Many theories have been proposed including actions on the forming blood vessels. However, thalidomide survivors also have altered nerve patterns and the drug is known for its neurotoxic actions in adults following prolonged use. We have previously shown that CPS49, an anti-angiogenic analog of thalidomide, causes a range of limb malformations in a time-sensitive manner in chicken embryos...
October 10, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28975826/prevalence-and-severity-of-osteochondrosis-of-the-free-thoracic-vertebra-in-three-modern-broiler-strains-and-the-athens-canadian-random-bred-control-broiler
#2
Laura R Chen, M Mitsu Suyemoto, Albarra H Sarsour, H Alejandro Cordova, Edgar O Oviedo-Rondón, H John Barnes, Luke B Borst
Osteochondrosis (OCD) results from a disturbance of endochondral ossification in articular cartilage and is an important cause of lameness in several animal species including chickens. OCD lesions in the free thoracic vertebra (FTV) of chickens are essential to the pathogenesis of pathogenic Enterococcus cecorum. The goal of this study was to determine the prevalence of OCD in the FTV among three modern broiler chicken crosses (strains A/A, A/B, and C/C) and Athens Canadian Random Bred (ACRB) chickens, which served as a control group...
October 4, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28971570/chondroblastoma-of-extra-craniofacial-bones-clinicopathological-analyses-of-103-cases
#3
Eiichi Konishi, Yasuaki Nakashima, Masayuki Mano, Yasuhiko Tomita, Toshikazu Kubo, Nobuhito Araki, Eiichi Morii, Hideki Yoshikawa, Hironori Haga, Junya Toguchida, Takafumi Ueda, Masahiko Osawa, Manabu Hoshi, Takeshi Inoue, Masanari Aono, Akio Yanagisawa
We elucidated clinicopathological characteristics of chondroblastoma (CB) in Japan, and reliable clinicopathologic parameters predicting local recurrence and/or metastasis. Clinicopathological profiles of 103 CB (80 male, 23 female) in extra-craniofacial bones were retrieved. Numerical scoring of nine pathological and five radiological features was statistically analyzed to determine prognostic significance. Age ranged 8-61 years (average 19.6 years). Frequently involved sites were femur, tibia, calcaneus, patella and humerus...
October 2017: Pathology International
https://www.readbyqxmd.com/read/28957003/in-vitro-effect-of-apigenin-and-danshen-in-tibial-dyschondroplasia-through-inhibition-of-heat-shock-protein-90-and-vascular-endothelial-growth-factor-expressions-in-avian-growth-plate-cells
#4
Khalid Mehmood, Hui Zhang, Muhammad Kashif Iqbal, Mujeeb Ur Rehman, Muhammad Shahzad, Kun Li, Shucheng Huang, Fazul Nabi, Lihong Zhang, Jiakui Li
Tibial dyschondroplasia (TD) is one of the common skeletal abnormalities in fast-growing birds, and it is characterized by nonvascularized, unmineralized, and nonviable cartilage in the tibial growth plate that fails to form bone. The aim of this study was to check the in vitro effect of apigenin and danshen on heat-shock protein 90 (Hsp90) and vascular endothelial growth factor (VEGF) expressions in avian growth plate cells treated with sublethal concentration of thiram. Initially, chondrocytes from chicken growth plates were isolated on culturx ed medium with and without various concentration of thiram to determine the sublethal dose...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28929384/roles-of-dietary-glycine-proline-and-hydroxyproline-in-collagen-synthesis-and-animal-growth
#5
REVIEW
Peng Li, Guoyao Wu
Glycine, proline, and hydroxyproline (Hyp) contribute to 57% of total amino acids (AAs) in collagen, which accounts for one-third of proteins in animals. As the most abundant protein in the body, collagen is essential to maintain the normal structure and strength of connective tissue, such as bones, skin, cartilage, and blood vessels. Mammals, birds, and fish can synthesize: (1) glycine from threonine, serine, choline, and Hyp; (2) proline from arginine; and (3) Hyp from proline residues in collagen, in a cell- and tissue-specific manner...
September 20, 2017: Amino Acids
https://www.readbyqxmd.com/read/28888901/oral-administration-of-undenatured-native-chicken-type-ii-collagen-uc-ii-diminished-deterioration-of-articular-cartilage-in-a-rat-model-of-osteoarthritis-oa
#6
C M Bagi, E R Berryman, S Teo, N E Lane
OBJECTIVE: The aim of this study was to determine the ability of undenatured native chicken type II collagen (UC-II) to prevent excessive articular cartilage deterioration in a rat model of osteoarthritis (OA). METHODS: Twenty male rats were subjected to partial medial meniscectomy tear (PMMT) surgery to induce OA. Immediately after the surgery 10 rats received vehicle and another 10 rats oral daily dose of UC-II at 0.66 mg/kg for a period of 8 weeks. In addition 10 naïve rats were used as an intact control and another 10 rats received sham surgery...
September 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28831181/tibial-dyschondroplasia-is-highly-associated-with-suppression-of-tibial-angiogenesis-through-regulating-the-hif-1%C3%AE-vegf-vegfr-signaling-pathway-in-chickens
#7
Shu-Cheng Huang, Mujeeb Ur Rehman, Yan-Fang Lan, Gang Qiu, Hui Zhang, Muhammad Kashif Iqbal, Hou-Qiang Luo, Khalid Mehmood, Li-Hong Zhang, Jia-Kui Li
Tibial dyschondroplasia (TD) is an intractable poultry problem that is characterized by the appearance of non-vascularized and non-mineralized cartilage masses in tibial growth plates (TGPs). However, the role of angiogenesis inhibition in the occurrence of TD remains unknown. In this study, we found that, compared to low-altitude Arbor Acres chickens (AACs), high-altitude Tibetan chickens showed higher tibial vascular distributions that were accompanied by up-regulation of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor A (VEGFA) and VEGF receptors...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710591/effect-of-dietary-phytase-supplementation-on-bone-and-hyaline-cartilage-development-of-broilers-fed-with-organically-complexed-copper-in-a-cu-deficient-diet
#8
Siemowit Muszyński, Ewa Tomaszewska, Małgorzata Kwiecień, Piotr Dobrowolski, Agnieszka Tomczyk
Tibial mechanical, chemical, and histomorphometrical traits were investigated for growing male Ross 308 broiler chickens fed diets that had copper (Cu) from organic source at a lowered level of 25% of the daily requirement (4 mg kg(-1) of a premix) with or without phytase. Dietary treatments were control non-copper, non-phytase group (0 Suppl); 4 mg kg(-1) Cu non-phytase group (25%Cu); and 4 mg kg(-1) Cu + 500 FTU kg(-1) phytase group (25%Cu + phyt). The results show that birds fed with the addition of phytase exhibited improved weight gain and final body weight and had increased serum IGF-1 and osteocalcin concentrations...
July 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28618762/antiinflammatory-and-antioxidant-effects-of-gemcitabine-in-collagen-induced-arthritis-model
#9
Adile Ferda Dağli, Ahmet Karataş, Cemal Orhan, Mehmet Tuzcu, Metin Özgen, Kazım Şahin, Süleyman Serdar Koca
BACKGROUND/AIM: Gemcitabine (GEM) has antiproliferative effects on lymphocytes, which are potent pathogenic actors of rheumatoid arthritis (RA). The aim of the study was to investigate the therapeutic potential of GEM on collagen-induced arthritis (CIA). MATERIALS AND METHODS: Arthritis was induced by the intradermal injection of chicken type II collagen with incomplete Freund's adjuvant into albino Wistar rats. Doses of 5 and 20 mg/kg GEM were administered twice a week after the 14th day, which marked the onset the arthritis...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28536017/do-chondroitin-sulfates-with-different-structures-have-different-activities-on-chondrocytes-and-macrophages
#10
André L da Cunha, Jair A K Aguiar, Flavio S Correa da Silva, Yara M Michelacci
The aim of the present study was to investigate the activities of natural chondroitin sulfates (CS) with different structures on cultured chondrocytes and macrophages. CS were isolated from cartilages of bovine trachea (BT), porcine trachea (PT), chicken sternum (Ch) and skate (Sk). The preparations were 90-98% pure, with ∼1% proteins, nucleic acids and keratan sulfate contaminants. Structural analysis of these CS and of commercial chondroitin 4- and 6-sulfate (C4S, C6S) have shown that most of their disaccharides are monosulfated, with varying proportions of 4- and 6-sulfation, and 2-7% non-sulfated disaccharides...
October 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28472711/characterizing-viscoelasticity-of-unhydrolyzed-chicken-sternal-cartilage-extract-suspensions-towards-development-of-injectable-therapeutics-formulations
#11
Brian Hama, Gautam Mahajan, Chandrasekhar Kothapalli
Exogenous delivery of cartilage extract is being explored as a promising candidate for knee arthritis treatment as it biomimics native cartilage tissue characteristics. In this study, we report on the rheological characterization of aqueous suspensions constituted from a powdered form of unhydrolyzed chicken sternum extract. The effect of particle size (as-received vs. milled), suspension fluid (water vs. PBS), and temperature (37°C vs. 4°C), on the viscoelastic properties of the sternum extract based particulate suspensions were evaluated...
April 26, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28267633/sclerostin-stimulates-angiogenesis-in-human-endothelial-cells
#12
Angela Oranger, Giacomina Brunetti, Graziana Colaianni, Roberto Tamma, Claudia Carbone, Luciana Lippo, Giorgio Mori, Paolo Pignataro, Nunzio Cirulli, Roberta Zerlotin, Biagio Moretti, Angela Notarnicola, Domenico Ribatti, Maria Grano, Silvia Colucci
Sclerostin, negative regulator of bone formation, has been originally known as an osteocyte product. Recently, it has been also detected in hypertrophic chondrocytes, distinctive cells of avascular cartilage which is invaded by capillaries and then replaced by vascularized bone. Thus, we hypothesized that sclerostin, in addition to its role already known, may exert an angiogenic activity. We first proved that sclerostin increased the proliferation of human umbilical vein endothelial cells (HUVECs), and next, by using the chicken chorioallantoic membrane (CAM) in vivo assay, we demonstrated that it exerts an angiogenic activity similar to that of vascular endothelial growth factor (VEGF)...
March 4, 2017: Bone
https://www.readbyqxmd.com/read/28145573/static-osteogenesis-does-not-precede-dynamic-osteogenesis-in-periosteal-ossification-of-pleurodeles-caudata-amphibia-and-pogona-squamata-lepidosauria
#13
Jorge Cubo, Mylaine Hui, François Clarac, Alexandra Quilhac
Two successive mechanisms have been described in perichondral ossification: (1) in static osteogenesis, mesenchymal cells differentiate into stationary osteoblasts oriented randomly, which differentiate into osteocytes in the same site; (2) in dynamic osteogenesis, mesenchymal cells differentiate into osteoblasts that are all oriented in the same direction and move back as they secrete collagen fibers. This study is aimed at testing the hypothesis that the ontogenetic sequence static then dynamic osteogenesis observed in the chicken and in the rabbit is homologous and was acquired by the last common ancestor of amniotes or at a more inclusive node...
May 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28118357/endochondral-ossification-is-accelerated-in-cholinesterase-deficient-mice-and-in-avian-mesenchymal-micromass-cultures
#14
Janine Spieker, Thomas Mudersbach, Astrid Vogel-Höpker, Paul G Layer
Most components of the cholinergic system are detected in skeletogenic cell types in vitro, yet the function of this system in skeletogenesis remains unclear. Here, we analyzed endochondral ossification in mutant murine fetuses, in which genes of the rate-limiting cholinergic enzymes acetyl- (AChE), or butyrylcholinesterase (BChE), or both were deleted (called here A-B+, A+B-, A-B-, respectively). In all mutant embryos bone growth and cartilage remodeling into mineralizing bone were accelerated, as revealed by Alcian blue (A-blu) and Alizarin red (A-red) staining...
2017: PloS One
https://www.readbyqxmd.com/read/28076010/foreign-bodies-on-lateral-neck-radiographs-in-adults-imaging-findings-and-common-pitfalls
#15
REVIEW
Alba Castán Senar, Laura E Dinu, José M Artigas, Raquel Larrosa, Ylenia Navarro, Elena Angulo
Foreign-body (FB) ingestion is less common in adults than in children, but still occurs. Diagnostic management of patients with suspected FB ingestion in emergency departments depends on FB type and location, both of which are related to the patient profile. In adults, fish and chicken bones are the most common FB types, and the oropharynx and cricopharyngeal muscle are the most common locations. Once accidentally swallowed, an FB may become lodged in the oropharynx, and in such cases indirect or fiberoptic laryngoscopy is the first clinical management option...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28038739/physicochemical-antioxidant-and-biocompatible-properties-of-chondroitin-sulphate-isolated-from-chicken-keel-bone-for-potential-biomedical-applications
#16
Aruna Rani, Rwivoo Baruah, Arun Goyal
Chicken keel bone cartilage was explored for cheaper and sustainable source for isolation of chondroitin sulphate (CS) for its future use in tissue engineering and pharmaceutical industry. HPSEC analysis displayed two peaks of 100kDa for CS-keel polysaccharide and 1kDa for protein. DLS analysis of CS-keel displayed polydispersity. CS-keel yield was 15% and 53±5% uronic acid content. The quantified percentages of UA-GalNAc4S and UA-GalNAc6S disaccharide in CS-keel were 58% and 42%, respectively. FT-IR identified CS-keel to be chondroitin 4-sulphate...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27921302/the-role-of-embryo-movement-in-the-development-of-the-furcula
#17
A S Pollard, S Boyd, I M McGonnell, A A Pitsillides
The pectoral girdle is a complex structure which varies in its morphology between species. A major component in birds is the furcula, which can be considered equivalent to a fusion of the paired clavicles found in many mammals, and the single interclavicle found in many reptiles. These elements are a remnant of the dermal skeleton and the only intramembranous bones in the trunk. Postnatally, the furcula plays important mechanical roles by stabilising the shoulder joint and acting as a mechanical spring during flight...
March 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/27861854/lectins-selectively-label-cartilage-condensations-and-the-otic-neuroepithelium-within-the-embryonic-chicken-head
#18
Poulomi Ray, Ami J Hughes, Misha Sharif, Susan C Chapman
Cartilage morphogenesis during endochondral ossification follows a progression of conserved developmental events. Cells are specified towards a prechondrogenic fate and subsequently undergo condensation followed by overt differentiation. Currently available molecular markers of prechondrogenic and condensing mesenchyme rely on common regulators of the chondrogenic program that are not specific to the tissue type or location. Therefore tissue-specific condensations cannot be distinguished based on known molecular markers...
March 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/27855926/sulfated-glycosaminoglycan-derived-oligosaccharides-produced-from-chicken-connective-tissue-promote-iron-uptake-in-a-human-intestinal-caco-2-cell-line
#19
Henan Wang, Mirko Betti
Food grade sulfated glycosaminoglycan (GAG) polysaccharides were successfully extracted from chicken cartilage and skin. Their respective oligosaccharides were obtained by bovine testicular hyaluronidase digestion. The antioxidant capacity was analyzed to determine the possible mechanism explaining how GAGs promote iron uptake by the Caco-2 cells. The sulfated GAG oligosaccharides derived from cartilage possessed the greatest DPPH scavenging and ferric reducing activities (p<0.05), but limited ferrous chelating activities...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27729062/screening-for-peptides-targeted-to-il-7r%C3%AE-for-molecular-imaging-of-rheumatoid-arthritis-synovium
#20
Carmen Burtea, Sophie Laurent, Tuba Sanli, Deborah Fanfone, Aude Devalckeneer, Sébastien Sauvage, Marie-Claire Beckers, Sandrine Rorive, Isabelle Salmon, Luce Vander Elst, Bernard R Lauwerys, Robert N Muller
BACKGROUND: Interleukin-7 receptor alpha (IL-7Rα) represents a biomarker with potential applications in rheumatoid arthritis (RA) diagnosis and therapy. We have therefore searched by phage display potential IL-7Rα specific peptides with the primary goal being to develop in vivo molecular imaging tools. METHODS: IL-7Rα-targeted peptides were searched within a disulfide-constrained combinatorial phage displayed library of random linear heptapeptides. The apparent dissociation constant (Kd) and half maximal inhibition constant (IC50) were estimated for phage clones and synthesized peptides by ELISA...
October 12, 2016: Arthritis Research & Therapy
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