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https://www.readbyqxmd.com/read/29675357/radiological-signs-associated-with-pulmonary-multi-drug-resistant-tuberculosis-an-analysis-of-published-evidences
#1
Yì Xiáng J Wáng, Myung Jin Chung, Aliaksandr Skrahin, Alex Rosenthal, Andrei Gabrielian, Michael Tartakovsky
Background: Despite that confirmative diagnosis of pulmonary drug-sensitive tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) is determined by microbiological testing, early suspicions of MDR-TB by chest imaging are highly desirable in order to guide diagnostic process. We aim to perform an analysis of currently available literatures on radiological signs associated with pulmonary MDR-TB. Methods: A literature search was performed using PubMed on January 29, 2018...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29663951/active-case-finding-and-treatment-adherence-in-risk-groups-in-the-tuberculosis-pre-elimination-era
#2
R K Gupta, M Lipman, A Story, A Hayward, G de Vries, R van Hest, C Erkens, M X Rangaka, I Abubakar
Vulnerable populations, including homeless persons, high-risk drug and alcohol users, prison inmates and other marginalised populations, contribute a disproportionate burden of tuberculosis (TB) cases in low-incidence settings. Drivers of this disease burden include an increased risk of both TB transmission in congregate settings, and progression from infection to active disease. Late diagnosis and poor treatment completion further propagate the epidemic and fuel the acquisition of drug resistance. These groups are therefore a major priority for TB control programmes in low-incidence settings...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29659636/prognostic-score-to-predict-mortality-during-tb-treatment-in-tb-hiv-co-infected-patients
#3
Duc T Nguyen, Helen E Jenkins, Edward A Graviss
BACKGROUND: Estimating mortality risk during TB treatment in HIV co-infected patients is challenging for health professionals, especially in a low TB prevalence population, due to the lack of a standardized prognostic system. The current study aimed to develop and validate a simple mortality prognostic scoring system for TB/HIV co-infected patients. METHODS: Using data from the CDC's Tuberculosis Genotyping Information Management System of TB patients in Texas reported from 01/2010 through 12/2016, age ≥15 years, HIV(+), and outcome being "completed" or "died", we developed and internally validated a mortality prognostic score using multiple logistic regression...
2018: PloS One
https://www.readbyqxmd.com/read/29653033/organometallic-conjugates-of-the-drug-sulfadoxine-for-combatting-antimicrobial-resistance
#4
Peter J Sadler, Prinessa Chellan, Vicky Avery, Sandra Duffy, James Triccas, Gayathri Nagalingam, Christina Tam, Luisa Cheng, Jenny Liu, Kirkwood Land, Guy Clarkson, Isolda Romero
Fourteen novel arene RuII, and cyclopentadienyl (Cpx) RhIII and IrIII complexes containing an N,N'-chelated pyridylimino- or quinolylimino ligand functionalized with the antimalarial drug sulfadoxine have been synthesized and characterized, including three by x-ray crystallography. Rhodium and iridium complexes exhibited potent antiplasmodial activity with IC50 values of 0.10 - 2.0 µM in either all, or one of the three Plasmodium falciparum assays (3D7 chloroquine sensitive, Dd2 chloroquine resistant and NF54 sexual late stage gametocytes), but were only moderately active towards Trichomonas vaginalis...
April 13, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29650301/-pulmonary-intravascular-talcosis-a-case-report
#5
J Reverso-Meinietti, F Vandenbos, K Risso, J Coyne, S Leroy, B Padovani, F Burel-Vandenbos
INTRODUCTION: Pulmonary intravascular talcosis is a rare condition occurring in intravenous drug users injecting oral medications. Talc results in a foreign-body granulomatous reaction giving a radiological haematogenic miliary appearance mimicking miliary tuberculosis. Drug users represent a population at risk for both these conditions and their distinction may be challenging. CASE REPORT: We reported the case of a man, 33 year-old, intravenous drug addict, detected by the health services because he was the partner of a person who died of contagious and multi-resistant tuberculosis...
April 9, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29642880/prevalence-of-latent-tuberculosis-infection-among-coal-workers-pneumoconiosis-patients-in-china-a-cross-sectional-study
#6
Yan Jin, Huanqiang Wang, Jianfang Zhang, Chunguang Ding, Ke Wen, Jingguang Fan, Tao Li
BACKGROUND: Little is known about the prevalence of latent tuberculosis infection (LTBI) among coal workers' pneumoconiosis (CWP) patients. To estimate the prevalence of LTBI and identify its associated risk factors among CWP patients. METHODS: A cross-sectional study was conducted to assess the prevalence of LTBI. Participants were screened for active TB or a history of TB by X-ray and those that underwent QuantiFERON-TB Gold In-Tube (QFT) test. A standardized questionnaire was completed and risk factors were assessed for acquiring TB...
April 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29630082/pulmonary-hydatid-disease-with-aspergillosis-an-unusual-association-in-an-immunocompetent-host
#7
Rahul Chanderhas Goyal, Ruchita Tyagi, Bhavna Garg, Atul Mishra, Neena Sood
Echinococcosis is a common cause of pulmonary cavities. Aspergillus fumigatus, a saprophytic fungus, can colonise pulmonary cavities caused by tuberculosis, sarcoidosis, echinococcosis, bronchiectasis and neoplasms. Infection by Aspergillus is often seen in immunosuppressed cases. However, co-infection of Aspergillus with pulmonary echinococcosis is unexpected and very unusual, especially in an immunocompetent patient. We present the case of a 45-year-old immunocompetent male who came with non-resolving pneumonia and fever for 8 months and dyspnoea since 15 days accompanied by recurrent episodes of hemoptysis since 5 days...
April 9, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29625212/development-and-characterization-of-high-payload-combination-dry-powders-of-anti-tubercular-drugs-for-treating-pulmonary-tuberculosis
#8
Basanth Babu Eedara, Bhamini Rangnekar, Shubhra Sinha, Colin Doyle, Alex Cavallaro, Shyamal C Das
This study aimed to develop a high payload dry powder inhalation formulation containing a combination of the first line anti-TB drug, pyrazinamide, and the second line drug, moxifloxacin HCl. Individual powders of pyrazinamide (PSD ) and moxifloxacin (MSD ) and combination powders of the two drugs without (PM) and with 10% L-leucine (PML) and 10% DPPC (PMLD) were produced by spray drying. PSD contained >10 μm crystalline particles and showed poor aerosolization behaviour with a fine particle fraction (FPF) of 18...
April 3, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29624868/design-synthesis-and-in-vitro-anti-tubercular-activity-of-1-2-3-triazolyl-dihydroquinoline-derivatives
#9
Saleha Banu, Rajitha Bollu, Lingaiah Nagarapu, Jagadeesh Babu Nanubolu, Yogeswari Perumal, Dharmarajan Sriram, Shravan Kumar Gunda, Divyasphoorthi Vardhan
In the quest for new active molecules against Mycobacterium tuberculosis, a series of dihydroquinoline derivatives possessing triazolo substituents were efficiently synthesized using click chemistry. The structure of 6l was evidenced by X-ray crystallographic study. The newly synthesized compounds were evaluated for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC27294). The compounds 6a, 6g and 6j (MIC: 3.13 μg/mL) showed promising activity when compared to the first line drug such as ethambutol...
April 6, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29601187/characterization-of-tetrahydrolipstatin-and-stereo-derivatives-on-the-inhibition-of-essential-mycobacterium-tuberculosis-lipid-esterases
#10
Christopher M Goins, Thanuja D Sudasinghe, Xiaofan Liu, Yanping Wang, George A O'Doherty, Donald R Ronning
Tetrahydrolipstatin (THL) is a covalent inhibitor of many serine esterases. In mycobacteria, THL has been found to covalently react with 261 lipid esterases upon treatment of Mycobacterium bovis cell lysate. However, the covalent adduct is considered unstable in some cases due to the hydrolysis of the enzyme-linked THL adduct resulting in catalytic turnover. In this study, a library of THL stereo-derivatives was tested against three essential Mycobacterium tuberculosis lipid esterases of interest for drug development to assess how the stereochemistry of THL affects respective enzyme inhibition and allows for cross-enzyme inhibition...
March 30, 2018: Biochemistry
https://www.readbyqxmd.com/read/29584796/should-sputum-negative-presumptive-tb-patients-be-actively-followed-to-identify-missing-cases-in-india
#11
S Waikar, A Pathak, V Ghule, A Kapoor, K Sagili, E R Babu, S Chadha
Setting: Sputum smear microscopy, the primary diagnostic tool used for diagnosis of tuberculosis (TB) in India's Revised National TB Control Programme (RNTCP), has low sensitivity, resulting in a significant number of TB cases reported as sputum-negative. As the revised guidelines pose challenges in implementation, sputum-negative presumptive TB (SNPT) patients are subjected to 2 weeks of antibiotics, followed by chest X-ray (CXR), resulting in significant loss to care among these cases. Objective: To determine whether reducing delays in CXR would yield additional TB cases and reduce initial loss to follow-up for diagnosis among SNPT cases...
December 21, 2017: Public Health Action
https://www.readbyqxmd.com/read/29579426/prevalence-of-pulmonary-tuberculosis-among-adults-in-selected-slums-of-delhi-city
#12
Rohit Sarin, Vikram Vohra, U K Khalid, Prem Prakash Sharma, Vineet Chadha, M A Sharada
BACKGROUND: A survey was carried out to estimate the point prevalence of bacteriologically positive pulmonary tuberculosis (PTB) among persons ≥15 years of age residing in Jhuggi-Jhopri (JJ) colonies - urban slums in Delhi, India implementing Directly Observed Treatment strategy since 1998. METHODS: Among 12 JJ colonies selected by simple random sampling, persons having persistent cough for ≥2 weeks at the time of the survey or cough of any duration along with history of contact/currently on ant-TB treatment/known HIV positive were subjected to sputum examination - 2 specimens, by smear microscopy for Acid Fast Bacilli and culture for Mycobacterium tuberculosis...
April 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29564278/thrombocytopenia-in-hiv-patients-coinfected-with-tuberculosis
#13
A S Sandhya, Brijesh Prajapat
Thrombocytopenia is one of the most common hematological manifestations seen in HIV patients with approximately 40% of the patients developing thrombocytopenia during their course of illness. Opportunistic infection like tuberculosis is a rare but curative cause of thrombocytopenia in these patients. Clinically, it is a challenge to determine the exact cause and decide the treatment of thrombocytopenia in these patients as both infections can lead to significant thrombocytopenia by varied mechanisms. The treatment options are limited by drug antitubercular treatment highly active antiretroviral therapy (ATT and HAART)-induced thrombocytopenia...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29560021/evaluating-a-framework-for-tuberculosis-screening-among-healthcare-workers-in-clinical-settings-inner-mongolia-china
#14
Shiming Cheng, Deanna Tollefson, Guangxue He, Yuan Li, Hui Guo, Shua Chai, Fangfang Gao, Fei Gao, Guoxin Han, Liping Ren, Yulin Ren, Jianbo Li, Lixia Wang, Jay K Varma, Dongmei Hu, Haiying Fan, Fei Zhao, Emily Bloss, Yu Wang, Carol Y Rao
Background: Health care workers are at high risk for tuberculosis (TB). China, a high burden TB country, has no policy on medical surveillance for TB among healthcare workers. In this paper, we evaluate whether China's national TB diagnostic guidelines could be used as a framework to screen healthcare workers for pulmonary TB disease in a clinical setting in China. Methods: Between April-August 2010, healthcare workers from 28 facilities in Inner Mongolia Autonomous Region, China were eligible for TB screening, comprised of symptom check, chest X-ray and tuberculin skin testing...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29557089/tuberculosis-burden-among-household-pediatric-contacts-of-adult-tuberculosis-patients
#15
Rajeshwar Dayal, Dipti Agarwal, Rakesh Bhatia, C Bipin, Neeraj Kumar Yadav, Santosh Kumar, Shamrendra Narayan, Ankur Goyal
OBJECTIVES: To find out the prevalence of latent tuberculosis (TB) infection and TB disease among pediatric household contacts of adult drug resistant (MDR) and drug susceptible (DS) TB patients and to identify the risk factors for occurrence of TB infection in the contacts. METHODS: Pediatric household contacts (less than 15 y age) of adult TB patients (both MDR and DS) were included in the study. They were categorized as latent TB infection (LTBI), TB disease and TB exposed based on the results of tuberculin skin testing (TST), clinical examination and chest X-ray...
March 20, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29547284/a-fragment-based-approach-to-targeting-inosine-5%C3%A2-monophosphate-dehydrogenase-impdh-from-mycobacterium-tuberculosis
#16
Ana Trapero, Angela Pacitto, Vinayak Singh, Mohamad Sabbah, Anthony G Coyne, Valerie Mizrahi, Tom L Blundell, David B Ascher, Chris Abell
Tuberculosis (TB) remains a major cause of mortality worldwide, and improved treatments are needed to combat emergence of drug resistance. Inosine 5´-monophosphate dehydrogenase (IMPDH), a crucial enzyme required for de novo synthesis of guanine nucleotides, is an attractive TB drug target. Herein, we describe the identification of potent IMPDH inhibitors using fragment-based screening and structure-based design techniques. Screening of a fragment library for Mycobacterium thermoresistible (Mth) IMPDH(ΔCBS) inhibitors identified a low affinity phenylimidazole derivative...
March 16, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29537407/disseminated-tuberculosis-diagnostic-challenges-of-atrial-tuberculoma-masquerading-as-atrial-myxoma
#17
A Alaga, Y X Yew, M K Razul
A 47-year-old female, with multiple comorbidities, presented with a cough of two months, loss of weight and appetite. She was treated for pneumonia. A chest X-ray showed bilateral reticulonodular opacities. She was noted to have a vague central abdominal mass and a systolic murmur over the mitral region. Ultrasonography and computed tomography of the abdomen showed an omental mass and loculated ascites. Oesophagoduedenoscopy showed antral gastritis and during colonoscopy the surgical team was unable to advance the scope beyond 40 cm due to external compression...
December 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29534104/genotyping-and-spatial-analysis-of-pulmonary-tuberculosis-and-diabetes-cases-in-the-state-of-veracruz-mexico
#18
Francles Blanco-Guillot, M Lucía Castañeda-Cediel, Pablo Cruz-Hervert, Leticia Ferreyra-Reyes, Guadalupe Delgado-Sánchez, Elizabeth Ferreira-Guerrero, Rogelio Montero-Campos, Miriam Bobadilla-Del-Valle, Rosa Areli Martínez-Gamboa, Pedro Torres-González, Norma Téllez-Vazquez, Sergio Canizales-Quintero, Mercedes Yanes-Lane, Norma Mongua-Rodríguez, Alfredo Ponce-de-León, José Sifuentes-Osornio, Lourdes García-García
BACKGROUND: Genotyping and georeferencing in tuberculosis (TB) have been used to characterize the distribution of the disease and occurrence of transmission within specific groups and communities. OBJECTIVE: The objective of this study was to test the hypothesis that diabetes mellitus (DM) and pulmonary TB may occur in spatial and molecular aggregations. MATERIAL AND METHODS: Retrospective cohort study of patients with pulmonary TB. The study area included 12 municipalities in the Sanitary Jurisdiction of Orizaba, Veracruz, México...
2018: PloS One
https://www.readbyqxmd.com/read/29528048/using-biomarkers-to-predict-tb-treatment-duration-predict-tb-a-prospective-randomized-noninferiority-treatment-shortening-clinical-trial
#19
Ray Y Chen, Laura E Via, Lori E Dodd, Gerhard Walzl, Stephanus T Malherbe, André G Loxton, Rodney Dawson, Robert J Wilkinson, Friedrich Thienemann, Michele Tameris, Mark Hatherill, Andreas H Diacon, Xin Liu, Jin Xing, Xiaowei Jin, Zhenya Ma, Shouguo Pan, Guolong Zhang, Qian Gao, Qi Jiang, Hong Zhu, Lili Liang, Hongfei Duan, Taeksun Song, David Alland, Michael Tartakovsky, Alex Rosenthal, Christopher Whalen, Michael Duvenhage, Ying Cai, Lisa C Goldfeder, Kriti Arora, Bronwyn Smith, Jill Winter, Clifton E Barry Iii
Background : By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months, maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have failed, with 4-month arms consistently having relapse rates of 15-20%. One trial shortened treatment only among those without baseline cavity on chest x-ray and whose month 2 sputum culture converted to negative. The 4-month arm relapse rate decreased to 7% but was still significantly worse than the 6-month arm (1.6%, P<0.01).  We hypothesize that PET/CT characteristics at baseline, PET/CT changes at one month, and markers of residual bacterial load will identify patients with tuberculosis who can be cured with 4 months (16 weeks) of standard treatment...
November 6, 2017: Gates open research
https://www.readbyqxmd.com/read/29524618/the-influence-of-surface-active-l-leucine-and-1-2-dipalmitoyl-sn-glycero-3-phosphatidylcholine-dppc-in-the-improvement-of-aerosolization-of-pyrazinamide-and-moxifloxacin-co-spray-dried-powders
#20
Basanth Babu Eedara, Bhamini Rangnekar, Colin Doyle, Alex Cavallaro, Shyamal C Das
Pharmacotherapy of tuberculosis is potentially more efficient when delivered by the inhaled route than by the current oral and/or parenteral routes due to the higher concentration of drug reaching the primary region of infection in the lungs. This study investigated the influence of the amino acid L-leucine alone and in combination with the phospholipid, 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), on the aerosolization behaviour of the anti-TB drugs, pyrazinamide and moxifloxacin HCl. Spray dried powders of pyrazinamide (P), moxifloxacin (M) alone and in combination with 10% L-leucine (PL and ML) and 10% DPPC (PLD and MLD) were produced...
March 7, 2018: International Journal of Pharmaceutics
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