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https://www.readbyqxmd.com/read/28214275/detection-of-pneumocystis-jirovecii-by-nested-pcr-in-hiv-negative-patients-with-pulmonary-disease
#1
Cristina Rodrigues Santos, Ângela M de Assis, Edson A Luz, Luzia Lyra, Ivan F Toro, José Claudio C Seabra, Dira H Daldin, Tathiane U Marcalto, Marcos T Galasso, Ronaldo F Macedo, Angélica Z Schreiber, Francisco H Aoki
BACKGROUND: Nested PCR can be used to determine the status of Pneumocystis jirovecii infection in other lung diseases. AIMS: This study sought to detect a target DNA fragment (mitochondrial large subunit rRNA or mtL SUrRNA) of P. jirovecii in patients with lung disease who underwent bronchoscopy with collection of bronchoalveolar lavage (BAL). METHODS: The results from toluidine blue staining were compared with those obtained using molecular methods that included an "in house" DNA extraction procedure, PCR and nested PCR...
February 14, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28208927/tuberculosis-of-glans-penis-a-rare-presentation
#2
C Gangalakshmi, Sankaramahalingam
Tuberculosis (TB) of penis is a very rare entity, even in developing countries. It may present as primary or secondary to Pulmonary TB (PTB). Penile TB mimics carcinoma penis, granulomatous penile ulcer, genital herpes simplex, granuloma inguinale and HIV infection. We, hereby, present the case of a 57-year-old male patient who presented to us with ulcerative growth over glans penis and was clinically diagnosed as carcinoma penis, however biopsy of the lesion showed evidence of tuberculosis which was supported by chest X-ray...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28185620/pulmonary-tuberculosis
#3
Sarah M Lyon, Milton D Rossman
This review on pulmonary tuberculosis includes an introduction that describes how the lung is the portal of entry for the tuberculosis bacilli to enter the body and then spread to the rest of the body. The symptoms and signs of both primary and reactivation tuberculosis are described. Routine laboratory tests are rarely helpful for making the diagnosis of tuberculosis. The differences between the chest X ray in primary and reactivation tuberculosis is also described. The chest computed tomography appearance in primary and reactivation tuberculosis is also described...
January 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28170135/diagnostic-potential-of-interferon-gamma-release-assay-to-detect-latent-tuberculosis-infection-in-kidney-transplant-recipients
#4
Jameela Edathodu, Bright Varghese, Abdulrahman A Alrajhi, Mohammed Shoukri, Ahmad Nazmi, Hazem Elgamal, Hassan Aleid, Fahad Alrabiah, Aattia Ashraff, Ihab Mahmoud, Sahal Al-Hajoj
BACKGROUND: Latent tuberculosis (TB) infection (LTBI) is screened by using clinical assessment, tuberculin skin test (TST), chest radiography and recently by interferon-gamma release assays (IGRA). The objective of this study was to evaluate the diagnostic potential of QuantiFERON(®) -TB Gold In-Tube test (QFT) for diagnosing LTBI in patients planned for kidney transplantation. METHODS: All adult patients with end-stage renal disease, evaluated for kidney transplantation in a referral center from August 2008 till May 2013, were enrolled, after consenting in a prospective, observational, non-interventional study...
February 7, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28162798/-endobronchial-tuberculosis
#5
E Manal, Z Nahid, B Hanane, Y Najiba
BACKGROUND/AIM: The endobronchial tuberculosis (EBTB) is an uncommon type of tuberculosis. The respiratory symptoms in EBTB are usually nonspecific and misleading. The aim of the study is to determine the clinical features and diagnostic aspects of EBTB. PATIENTS AND METHODS: Twenty-eight cases of endobronchial tuberculosis collected from January 2009 to October 2015. RESULTS: EBTB was found in 16 females and 12 males. The mean age was 48 years...
February 2, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28157425/clinical-features-and-prognostic-factors-in-presumed-ocular-tuberculosis
#6
Cristhian A Urzua, Yrbani Lantigua, Sergio Abuauad, Paulina Liberman, Osvaldo Berger, Pablo Sabat, Victor Velasquez, Enzo Castiglione, Margarita Calonge
PURPOSE: To characterize the clinical features in patients with presumed ocular tuberculosis (TB) and determine prognostic factors of visual outcomes and complications in this disease. MATERIAL AND METHODS: Retrospective case series of 35 patients (29 females, 6 males) with presumed ocular TB from referral centers in Chile and Spain between 2002 and 2012. Medical records were reviewed, and data regarding clinical features, complications, best-corrected visual acuity (BCVA), duration of disease, extraocular manifestations, and therapy were retrieved...
February 3, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28157125/planarity-of-benzoylthiocarbazate-tuberculostatics-iii-diesters-of-3-2-hydroxybenzoyl-dithiocarbazic-acid
#7
Małgorzata Szczesio, Andrzej Olczak, Ida Mazerant, Katarzyna Gobis, Henryk Foks, Marek L Główka
Searches for new tuberculostatic agents are important considering the occurrence of drug-resistant strains of Mycobacterium tuberculosis. The structures of three new potentially tuberculostatic compounds, namely isopropyl methyl (2-hydroxybenzoyl)carbonohydrazonodithioate, C12H16N2O2S2, (Z)-benzyl methyl (2-hydroxybenzoyl)carbonohydrazonodithioate, C16H16N2O2S2, and dibenzyl (2-hydroxybenzoyl)carbonohydrazonodithioate propan-2-ol monosolvate, C22H20N2O2S2·C3H8O, were determined by X-ray diffraction. The mutual orientation of the three main fragments of the compounds, namely an aromatic ring, a dithioester group and a hydrazide group, can influence the biological activity of the compounds...
February 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28152082/bringing-state-of-the-art-diagnostics-to-vulnerable-populations-the-use-of-a-mobile-screening-unit-in-active-case-finding-for-tuberculosis-in-palawan-the-philippines
#8
Fukushi Morishita, Anna Marie Celina Gonzales Garfin, Woojin Lew, Kyung Hyun Oh, Rajendra-Prasad Yadav, Janeth Cuencaho Reston, Lenie Lucio Infante, Maria Rebethia Crueldad Acala, Dean Lim Palanca, Hee Jin Kim, Nobuyuki Nishikiori
BACKGROUND: Globally, case detection of tuberculosis (TB) has stabilized in recent years. Active case finding (ACF) has regained an increased attention as a complementary strategy to fill the case detection gap. In the Philippines, the DetecTB project implemented an innovative ACF strategy that offered a one-stop diagnostic service with a mobile unit equipped with enhanced diagnostic tools including chest X-ray (CXR) and Xpert®MTB/RIF (Xpert). The project targeted the rural poor, the urban poor, prison inmates, indigenous population and high school students...
2017: PloS One
https://www.readbyqxmd.com/read/28151863/miliary-tuberculosis-epidemiologicaland-clinical-analysis-of-large-case-series-from-moderate-to-low-tuberculosis-endemic-country
#9
Ali Mert, Ferhat Arslan, Tülin Kuyucu, Emine Nur Koç, Mesut Ylmaz, Demet Turan, Sedat Altn, Filiz Pehlivanoglu, Gonul Sengoz, Dilek Yldz, Ilyas Dokmetas, Suheyla Komur, Behice Kurtaran, Tuna Demirdal, Hüseyin A Erdem, Oguz Resat Sipahi, Ayse Batirel, Emine Parlak, Recep Tekin, Özlem Güzel Tunçcan, Ilker Inanc Balkan, Osman Hayran, Bahadr Ceylan
The aim of this study was to determine the clinical features, and outcome of the patients with miliary tuberculosis (TB).We retrospectively evaluated 263 patients (142 male, 121 female, mean age: 44 years, range: 16-89 years) with miliary TB. Criteria for the diagnosis of miliary TB were at least one of the followings in the presence of clinical presentation suggestive of miliary TB such as prolonged fever, night sweats, anorexia, weight loss: radiologic criterion and pathological criterion and/or microbiological criterion; pathological criterion and/or microbiological criterion...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28151657/evaluating-the-contribution-of-transition-state-destabilization-to-changes-in-the-residence-time-of-triazole-based-inha-inhibitors
#10
Lauren A Spagnuolo, Sandra Eltschkner, Weixuan Yu, Fereidoon Daryaee, Shabnam Davoodi, Susan E Knudson, Eleanor K H Allen, Jonathan Merino, Annica Pschibul, Ben Moree, Neil Thivalapill, James J Truglio, Joshua Salafsky, Richard A Slayden, Caroline Kisker, Peter J Tonge
A critical goal of lead compound selection and optimization is to maximize target engagement whilst minimizing off-target binding. Since target engagement is a function of both the thermodynamics and kinetics of drug-target interactions, it follows that the structures of both the ground states and transition states on the binding reaction coordinate are needed to rationally modulate the lifetime of the drug-target complex. Previously, we predicted the structure of the rate-limiting transition state that controlled the time-dependent inhibition of the enoyl-ACP reductase InhA...
February 2, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28101723/role-of-high-resolution-computerized-tomography-chest-in-identifying-tubercular-etiology-in-patients-diagnosed-as-eales-disease
#11
Ranju Kharel Sitaula, Vandana Iyer, Veena Noronha, Parthopratim Dutta Majumder, Jyotirmay Biswas
BACKGROUND: The high resolution computerized tomography of chest is an important diagnostic imaging tool to identify any pulmonary tubercular lesion. It's role in Eales' disease to identify any possible association with pulomonary tuberculosis has not been studied earlier. So, this study was conducted to assess the role of high resolution computerized tomography (HRCT) chest in identifying tuberculous etiology in Eales' disease. RESULTS: It was a retrospective study conducted at a tertiary care eye hospital in South India between January 2009 and October 2014 were included...
December 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/28075068/binding-and-processing-of-%C3%AE-lactam-antibiotics-by-the-transpeptidase-ldtmt2-from-mycobacterium-tuberculosis
#12
Eva Maria Steiner, Gunter Schneider, Robert Schnell
: β-lactam antibiotics represent a novel direction in the chemotherapy of tuberculosis that brings the peptidoglycan layer of the complex mycobacterial cell wall in focus as a therapeutic target. Peptidoglycan stability in Mycobacterium tuberculosis, especially during infection, relies on the nonconventional peptide cross-links formed by l,d-transpeptidases. These enzymes are known to be inhibited by β-lactams, primarily carbapenems, leading to a stable covalent modification at the enzyme active site...
January 11, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28074705/an-uncommon-cause-of-sciatic-pain-tuberculous-osteomyelitis-of-the-ischial-tuberosity
#13
Pieter De Mulder, Charlotte Harth, Louis Ide, Jurgen Vallaeys, Nick Baelde, Thomas De Bo
A 66-year-old Caucasian female presented with insidious sciatic pain leading to an uncommon diagnosis of tuberculous osteomyelitis with unknown portal entry. The patient did not report a history of a previous tuberculosis (TB) infection and her chest X-ray was negative for TB. Considering TB in the differential diagnosis of a 'bone abscess', it is of paramount importance to come to a correct diagnosis. Conventional radiographs still remain the first-line imaging modality for evaluation of skeletal symptomatology...
January 11, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28062417/pulmonary-tuberculosis-presenting-as-post-operative-fever-of-unknown-origin
#14
Patrick Bogue, Mhairi Bolland, Peter How, Harrison Benziger
Post-operative fever is common following emergency surgery. Investigation and management of post-operative fever can be challenging when a clear source of sepsis is not evident or the underlying source of infection is not recognised. We herein report a case of secondary pulmonary tuberculosis presenting as post-operative fever following emergency laparotomy for a perforated duodenal ulcer. This case of tuberculosis was diagnosed on day 41 post-operatively and prior inconclusive results meant that we relied mainly on re-visiting history and examination in order to identify 3 targeted investigations: plain chest X-ray, sputum sample and blood test...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28060846/prediction-of-under-detection-of-paediatric-tuberculosis-in-the-democratic-republic-of-congo-experience-of-six-years-in-the-south-kivu-province
#15
Emmanuel André, Yvette Lufungulo Bahati, Eric Mulume Musafiri, Olivier Bahati Rusumba, Dimitri Van der Linden, Francis Zech
INTRODUCTION: In the field of tuberculosis (TB), and particularly in regard to paediatric TB (PedTB), clinical skills of health professionals play an important role in determining quality of care. In an era where novel diagnostic technologies and efficient treatment regimens are being made available for the poorest, we must not divert our attention from the importance of clinical skills, as this deliverable remains the cornerstone of individualized patient care and ultimately the best assurance for optimal use of resources...
2017: PloS One
https://www.readbyqxmd.com/read/28060545/safety-and-immunogenicity-of-adenovirus-35-tb-vaccine-candidate-in-adults-with-active-or-previous-tb-a-randomized-trial
#16
Richard N van Zyl-Smit, Aliasgar Esmail, Mary E Bateman, Rodney Dawson, Jonathan Goldin, Eva van Rikxoort, Macaya Douoguih, Maria Grazia Pau, Jerald C Sadoff, J Bruce McClain, Margaret Ann Snowden, Jacqueline Benko, David A Hokey, Kathryn Tucker Rutkowski, Andrew Graves, Barbara Shepherd, Sadritdin Ishmukhamedov, Benjamin M N Kagina, Brian Abel, Willem A Hanekom, Thomas J Scriba, Eric D Bateman
RATIONALE: Administration of tuberculosis vaccines in participants with previous or current pulmonary tuberculosis may have the potential for causing harmful post-vaccination immunological (Koch-type) reactions. OBJECTIVES: To assess the safety and immunogenicity of three dose levels of the AERAS-402 live, replication-deficient adenovirus 35-vectored tuberculosis candidate vaccine, containing three mycobacterial antigens, in individuals with current or previous pulmonary tuberculosis...
January 6, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28053362/cost-effectiveness-of-screening-for-active-cases-of-tuberculosis-in-flanders-belgium
#17
G Suzanne A Smit, Ludwig Apers, Wouter Arrazola de Onate, Philippe Beutels, Pierre Dorny, An-Marie Forier, Kristien Janssens, Jean Macq, Ruud Mak, Sandrina Schol, Dirk Wildemeersch, Niko Speybroeck, Brecht Devleesschauwer
OBJECTIVE: To assess the cost-effectiveness of the tuberculosis screening activities currently funded by the Flemish government in Flanders, Belgium. METHODS: After estimating the expenses for 2013-2014 of each of nine screening components - which include high-risk groups, contacts and people who are seeking tuberculosis consultation at a centre for respiratory health care - and the associated costs per active case of tuberculosis identified between 2007 and 2014, we compared the cost-effectiveness of each component...
January 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28050691/yield-of-chest-x-ray-tuberculosis-screening-of-immigrants-during-the-european-refugee-crisis-of-2015-a-single-centre-experience
#18
Julius Matthias Weinrich, Roland Diel, Markus Sauer, Frank Oliver Henes, Karen Meywald-Walter, Gerhard Adam, Gerhard Schön, Peter Bannas
OBJECTIVE: Our aim was to determine the prevalence of tuberculosis (TB), the number needed to screen (NNS), and the diagnostic accuracy of chest X-ray (CXR) screening to detect active pulmonary TB during the 2015 European refugee crisis. MATERIALS AND METHODS: We evaluated data of all refugees who underwent CXR screening in a single-centre of one German metropolitan area in 2015. We determined the prevalence of TB, NNS, and accuracy of CXR to detect active pulmonary TB...
January 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28043641/association-of-slow-recovery-of-mycobacterium-africanum-infected-patients-posttreatment-with-high-content-of-persister-like-bacilli-in-pretreatment-sputum
#19
Leopold D Tientcheu, Andrew Bell, Oumie Secka, Abigail Ayorinde, Jacob Otu, Nathalie J Garton, Jayne S Sutherland, Martin O Ota, Martin Antonio, H M Dockrell, Beate Kampmann, Michael R Barer
OBJECTIVES/BACKGROUND: Mycobacterium africanum that causes 40% of tuberculosis (TB) in West Africa grows more slowly in culture and has similar transmission capacity compared with Mycobacterium tuberculosis, but M. africanum-exposed contacts progress more slowly to active disease. The presence of lipid body (LB) containing M. tuberculosis complex (MTBC) cells in sputum samples has been associated with mycobacterial transcriptomes indicating slow or no growth and persister-like antibiotic tolerance...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043589/tuberculosis-in-slaughtered-cattle-and-workers-in-some-abattoirs-of-baghdad-governorate
#20
A N Al-Thwani, M S Al-Mashhadani
OBJECTIVE/BACKGROUND: Tuberculosis (the white plague) is regarded as one of the most widespread infectious diseases and continues to be a leading cause of death and the most prominent public health problem worldwide. It is caused by Mycobacterium tuberculosis complex, which refers to a group of seven species; one of them known as Mycobacterium bovis-the cause of bovine-type tuberculosis-has an exceptionally wide host range. It infects cattle, humans, goats, cats, dogs, buffalo, and deer...
December 2016: International Journal of Mycobacteriology
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