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https://www.readbyqxmd.com/read/29169231/evaluating-imaging-pathology-concordance-and-discordance-after-ultrasound-guided-breast-biopsy
#1
Vivian Youngjean Park, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Min Jung Kim
Ultrasound (US)-guided breast biopsy has become the main method for diagnosing breast pathology, and it has a high diagnostic accuracy, approaching that of open surgical biopsy. However, methods for confirming adequate lesion retrieval after US-guided biopsy are relatively limited and false-negative results are unavoidable. Determining imaging-pathology concordance after US-guided biopsy is essential for validating the biopsy result and providing appropriate management. In this review article, we briefly present the results of US-guided breast biopsy; describe general aspects to consider when establishing imaging-pathology concordance; and review the various categories of imaging-pathology correlations and corresponding management strategies...
August 19, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29169229/novel-vertebral-indices-in-normal-and-spinal-disorder-dogs-using-computed-tomography
#2
Jongsu Lim, Youngmin Yoon, Taesung Hwang, Hee Chun Lee
This study was carried out to derive reference value of normal spine indices, and to evaluate the feasibility of the indices for computed tomography (CT). CT images and magnetic resonance imaging were acquired from clinically normal 12 beagle dogs for normal group and 50 dogs with 56 spinal disorders for patient group. Image acquisition regions were cervical spine (C2 to T1), thoracic spine (T1-T13) and lumbar spine (L1-L7). The measured indices are as follows; the ratio of width to height of spinal cord include dura matter (CR) and vertebral foramen (FR), and the ratio of cross sectional area of spinal cord to vertebral foramen (CFAR)...
November 23, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29169228/control-of-type-o-foot-and-mouth-disease-by-vaccination-in-south-korea-2014-2015
#3
Jong-Hyeon Park, Dongseob Tark, Kwang-Nyeong Lee, Ji-Eun Chun, Hyang-Sim Lee, Young-Joon Ko, Soo-Jeong Kye, Yong-Joo Kim, Jae-Ku Oem, Soyoon Ryoo, Sung-Bin Lim, Seo-Yong Lee, Joo-Hyung Choi, Mi-Kyeong Ko, Su-Hwa You, Myoung-Heon Lee, Byounghan Kim
On December 3, 2014, a type O foot-and-mouth disease (FMD) outbreak occurred in South Korea. Although vaccinations were administered, cases of FMD increased steadily for five months and reached 185 cases by April 2015. Most of the affected animals were pigs, which are vulnerable to vaccinations. The FMD virus belonged to the South-East Asia (SEA) topotype that had been observed three times in Korea from April 2010 to July 2014. However, the virus in December 2014 had a unique difference in a partial deletion of the 5' noncoding region, which had not been seen in the previous SEA topotype isolates that were identified in Korea...
November 23, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29169227/korean-red-ginseng-excitation-of-paraventricular-nucleus-neurons-via-non-nmda-glutamate-receptor-activation-in-mice
#4
Yiming Shen, Janardhan P Bhattarai, Soo Joung Park, Gyu Seung Lee, Pan Dong Ryu, Seong Kyu Han
It has been reported that Korean red ginseng (KRG) as a valuable and important traditional medicine has various effects on central nervous system suggesting its complicated actions. Paraventricular nucleus (PVN) neurons of hypothalamus play a critical role for stress responses and hormone secretions. Although many studies have reported the action mechanisms of KRG on various cell and systems, the direct membrane effects of KRG on the PVN neurons which are involved in stress response are still poorly understood...
November 23, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29169223/comparison-of-pfge-is6110-rflp-and-24-locus-miru-vntr-for-molecular-epidemiologic-typing-of-mycobacterium-tuberculosis-isolates-with-known-epidemic-connections
#5
Semi Jeon, Nara Lim, Sanghee Park, Misun Park, Seonghan Kim
Two molecular epidemiologic methods, IS6110 restriction fragment length polymorphism (IS6110-RFLP) and 24-locus mycobacterial interspersed repetitive unit-variable-number tandem repeat (MIRU-VNTR), are used worldwide in studies of Mycobacterium tuberculosis (MTB). Conversely, because of its poor resolution, pulsed-field gel electrophoresis (PFGE) is not widely used for MTB. In this study, we improved 24-locus MIRU-VNTR and PFGE protocols and compared the effectiveness of these approaches for the molecular typing of MTB using 75 clinical isolates obtained from a cohort investigation of high-risk populations infected with MTB...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29169222/metagenomic-approach-to-identifying-foodborne-pathogens-on-chinese-cabbage
#6
Daeho Kim, Sanghyun Hong, You-Tae Kim, Sangryeol Ryu, Hyeun Bum Kim, Ju-Hoon Lee
Foodborne illness represents a major threat to public health frequently attributed to pathogenic microorganisms on fresh produce. Recurrent outbreaks often come from vegetables that are grown close to or within the ground. Therefore, the first step to understanding the public health risk of microorganisms on fresh vegetables is to identify and describe microbial communities. We investigated phyllospheres on Chinese cabbage (Brassica rapa subsp. pekinensis, n=54). 16S rRNA gene amplicon sequencing targeting the V5-V6 region of 16S rRNA genes was conducted by employing the Illumina MiSeq system...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29169219/genome-analysis-of-the-naphthalene-degrading-pseudomonas-sp-as1-harboring-the-megaplasmid-pas1
#7
Jisun Kim, Woojun Park
Polycyclic aromatic hydrocarbons (PAHs), including naphthalene, are widely distributed in nature. Naphthalene has been regarded as a model PAH compound for investigating the mechanisms of bacterial PAH biodegradation. Pseudomonas sp. AS1 isolated from an arsenic-contaminated site is capable of growing on various aromatic compounds such as naphthalene, salicylate, and catechol, but not on gentisate. The genome of strain AS1 consists of a 6,126,864 bp circular chromosome and the 81,841 bp circular plasmid pAS1...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29169204/newborn-genetic-screening-for-spinal-muscular-atrophy-in-the-uk-the-views-of-the-general-population
#8
Felicity K Boardman, Chloe Sadler, Philip J Young
BACKGROUND: Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder and a leading genetic cause of infant death worldwide. However, there is no routine screening program for SMA in the UK. Lack of treatments and the inability of screening tests to accurately predict disease severity are among the key reasons implementation of screening has faltered in the UK. With the recent release of the first therapy for SMA (Nusinersen), calls are being made for a reconsideration of this stance; however, very little is known about the views of the general public...
November 23, 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29169200/-german-language-version-and-validation-of-the-risk-taking-behaviour-scale-rbs-k-for-high-risk-sports
#9
Anika Frühauf, Martin Niedermeier, Gerhard Ruedl, Matthew Barlow, Tim Woodman, Martin Kopp
Background High-risk sports, particularly climbing, kayaking and extreme skiing, have become increasingly popular. The most widely used psychological survey instrument with regard to risk behaviour in sports is the Sensation Seeking Model, mostly assessed by the Sensation Seeking Scale (SSS-V). Until recently, the literature discussed risk behaviour solely through this model. However, this scale does not measure risk-taking behaviours. In contrast, the Risk-Taking Behaviour Scale (RBS-K) is a three-item scale that measures risk behaviour in high-risk sports...
November 23, 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29169199/-internet-addiction-suicidality-and-non-suicidal-self-harming-behavior-a-systematic-review
#10
Toni Andreas Steinbüchel, Stephan Herpertz, Ina Külpmann, Aram Kehyayan, Jan Dieris-Hirche, Bert Theodor Te Wildt
Background Internet addiction (IA) is associated with a high rate of co-morbid mental disorders, especially depression, anxiety disorders, ADHD and personality disorders and a considerable level of psychological strain. In terms of risk assessment, the present work investigates the current research literature on suicidal behavior and non-suicidal self-injurious behavior (NSSI). Methods We performed a systematic literature search in 14 databases on title and abstract level for the most common keywords for IA, NSSI and suicidality...
November 23, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29169198/-changes-in-sense-of-coherence-mental-distress-and-satisfaction-with-life-and-studies-in-the-course-of-psychosocial-counselling
#11
Asimina Koutsoukou-Argyraki, Alina Bertolino, Volker Kreß, Frank-Hagen Hofmann, Michael Sperth, Rainer Matthias Holm-Hadulla
"Sense of coherence" (SOC) plays an essential role in the maintenance or recovery of health, according to the salutogenetic approach of Aaron Antonovsky. Empirical studies provide evidence of significant links between sense of coherence and different indicators of mental health. In the present study, the effectivity of an integrative counselling concept for the promotion of sense of coherence, reduction of mental distress and improvement of satisfaction with life was tested in a sample of 153 clients and patients...
November 23, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29169191/the-latest-developments-of-functional-molecular-imaging-in-the-diagnosis-of-primary-aldosteronism
#12
Mitsuhide Naruse, Hironobu Umakoshi, Mika Tsuiki, Maki Yokomoto, Tetsuya Tagami, Akiyo Tanabe, Akira Shimatsu
Differentiation of unilateral from bilateral aldosterone hypersecretion is the essential step in the clinical practice of primary aldosteronism (PA). Although adrenal venous sampling (AVS) has been established as the most standard test recommended by the guideline, its invasive and technically difficult nature has facilitated the approach to develop non-invasive functioning imaging as an alternative test. Compared to the conventional adrenocortical scintigraphy with cholesterol derivatives as tracer, the first-generation imaging, both of (11)C-MTO/PET and (123)I-IMTO/SPECT/CT, the second-generation imaging, bind with high specificity and affinity to CYP11B enzymes and have advantages in shortening the time for obtaining specific images, reducing the radiation exposure to the patient, and resolution of the images...
November 23, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29169187/biologically-active-orbitides-from-the-euphorbiaceae-family
#13
Suelem D Ramalho, Meri Emili F Pinto, Douglas Ferreira, Vanderlan S Bolzani
A comprehensive overview of natural orbitides isolated from Euphorbiaceae species and their most relevant biological activities are presented. Euphorbiaceae is a large and diverse family, which comprises about 300 genera, and is known as an important source of medicines and toxins. Several classes of secondary metabolites have been described for this taxon, however, orbitides have been broadly reported in Jatropha and Croton genera. Additionally, the latex is documented as the main source of orbitides in this family...
November 23, 2017: Planta Medica
https://www.readbyqxmd.com/read/29169183/myc-regulation-of-glutamine-proline-regulatory-axis-is-key-in-luminal-b-breast-cancer
#14
Madeleine L Craze, Hayley Cheung, Natasha Jewa, Nuno D M Coimbra, Daniele Soria, Rokaya El-Ansari, Mohammed A Aleskandarany, Kiu Wai Cheng, Maria Diez-Rodriguez, Christopher C Nolan, Ian O Ellis, Emad A Rakha, Andrew R Green
BACKGROUND: Altered cellular metabolism is a hallmark of cancer and some are reliant on glutamine for sustained proliferation and survival. We hypothesise that the glutamine-proline regulatory axis has a key role in breast cancer (BC) in the highly proliferative classes. METHODS: Glutaminase (GLS), pyrroline-5-carboxylate synthetase (ALDH18A1), and pyrroline-5-carboxylate reductase 1 (PYCR1) were assessed at DNA/mRNA/protein levels in large, well-characterised cohorts...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29169179/apolipoprotein-e-e4-allele-is-associated-with-subjective-cognitive-decline-a-meta-analysis
#15
Ting Zhang, Shuling Liu, Yajing Zhang, Yalin Guan, Xiaodan Wang, Lei Zhao, Zhihong Shi, Wei Yue, Ying Zhang, Shuai Liu, Yong Ji
BACKGROUND AND PURPOSE: Subjective cognitive decline (SCD) is a condition associated with increased risk of Alzheimer's disease. This study performs a meta-analysis to estimate the prevalence of the Apolipoprotein E e4 (APOE e4) allele in SCD and the association of APOE e4 with SCD. METHODS: The MEDLINE, EMBASE, and Cochrane Library databases were searched. Meta-analyses were conducted using STATA 12.0 software. When significant heterogeneity was present (I2 >50% and p < 0...
November 23, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29169174/melatonin-induced-changes-in-cytosolic-calcium-might-be-responsible-for-apoptosis-induction-in-tumour-cells
#16
Barbora Chovancova, Sona Hudecova, Lubomira Lencesova, Petr Babula, Ingeborg Rezuchova, Adela Penesova, Marian Grman, Roman Moravcik, Michal Zeman, Olga Krizanova
BACKGROUND/AIMS: Melatonin is a hormone transferring information about duration of darkness to the organism and is known to modulate several signaling pathways in the cells, e.g. generation of endoplasmic reticulum stress, oxidative status of the cells, etc. Melatonin has been shown to exert antiproliferative and cytotoxic effects on various human cancers. We proposed that this hormone can differently affect tumour cells and healthy cells. METHODS: We compared the effect of 24 h melatonin treatment on calcium transport (by fluorescent probes FLUO-3AM and Rhod-5N), ER stress (determined as changes in the expression of CHOP, XBP1 and fluorescently, using Thioflavin T), ROS formation (by CellROX® Green/Orange Reagent) and apoptosis induction (by Annexin-V-FLUOS/propidiumiodide) in two tumour cell lines - ovarian cancer cell line A2780 and stable cell line DLD1 derived from colorectal carcinoma, with non-tumour endothelial cell line EA...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169171/mirnas-are-unlikely-to-be-involved-in-retinoid-receptor-gene-regulation-in-pancreatic-cancer-cells
#17
Shuai Yin, Tim Bleul, Yifan Zhu, Orkhan Isayev, Jens Werner, Alexandr V Bazhin
BACKGROUND/AIMS: Retinoid receptors and retinoic acid were reported to be down-regulated in pancreatic duct adenocarcinoma (PDAC) compared to normal pancreas. Yet the mechanism of the down-regulation of retinoid receptors is not well defined. The aim of this study was to find out whether selected dysregulated miRNAs in PDAC are responsible for the decreased level of retinoid receptors. METHODS: Bioinformatics, real-time PCR, western blot analysis as well as molecular manipulation with miRNA in cells of PDAC were carried out...
November 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169170/mite-induced-asthma-and-ige-levels-to-shrimp-mite-tropomyosin-arginine-kinase-and-der-p-10-are-the-most-relevant-risk-factors-for-challenge-proven-shrimp-allergy
#18
Laura Farioli, Laura Michelina Losappio, Maria Gabriella Giuffrida, Valerio Pravettoni, Gianluigi Micarelli, Michele Nichelatti, Joseph Scibilia, Corrado Mirone, Laura Cavallarin, Cristina Lamberti, Luca Giuseppe Balossi, Elide Anna Pastorello
BACKGROUND: Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at issue is which in vivo and/or in vitro tests (food challenge, component-resolved diagnosis, house dust mite [HDM] sensitization) can help in distinguishing shrimp-allergic subjects from subjects that are sensitized but tolerant. METHODS: The aim of this study was to evaluate the role of IgE to the different shrimp and mite allergens in distinguishing shrimp challenge-positive from challenge-negative patients...
November 24, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29169169/effects-and-interactions-of-prenatal-ethanol-exposure-a-post-weaning-high-fat-diet-and-gender-on-adult-hypercholesterolemia-occurrence-in-offspring-rats
#19
Yongjian Qi, Hanwen Luo, Shuwei Hu, Yimeng Wu, Jacques Magdalou, Liaobin Chen, Hui Wang
BACKGROUND/AIMS: Prenatal ethanol exposure (PEE) could induce intrauterine programming of hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolism, resulting in intrauterine growth retardation and susceptibility to adult hypercholesterolemia in offspring. This study aimed to analyse the effects and interactions of PEE, a post-weaning high-fat diet (HFD) and gender on the occurrence of adult hypercholesterolemia in offspring rats. METHODS: Wistar female rats were treated with ethanol (4 g/kg...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169167/structural-pulmonary-abnormalities-still-evident-in-schoolchildren-with-new-bronchopulmonary-dysplasia
#20
Eveliina Ronkainen, Marja Perhomaa, Lauri Mattila, Mikko Hallman, Teija Dunder
BACKGROUND: A new pattern of bronchopulmonary dysplasia (BPD) has emerged with the improved survival of preterm children. OBJECTIVES: Our aim was to characterize structural abnormalities associated with new BPD and to evaluate whether the severity of high-resolution computed tomography (HRCT) changes is associated with lung function. METHODS: HRCT scans were performed on 21 schoolchildren with a history of new BPD (mild, n = 9; moderate, n = 4; and severe, n = 8) with a mean age of 12...
November 24, 2017: Neonatology
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