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https://www.readbyqxmd.com/read/29679599/mortality-in-pulmonary-arterial-hypertension-patients-treated-with-continuous-prostanoids
#1
S D Bartolome, N Sood, T S Shah, K Styrvoky, F T Torres, K M Chin
INTRODUCTION: Parenteral prostanoids are considered the treatment of choice for patients with severe pulmonary arterial hypertension (PAH). Prognostic studies for patients treated in the modern era are limited. METHODS: In this retrospective cohort study, patients initiating IV epoprostenol or IV or SC treprostinil therapy for PAH from 2007-2016 at UT Southwestern, Dallas, TX and Ohio State University, Columbus, OH were included. Transplant-free survival was assessed from the time of IV/SC initiation and from the time of first follow-up...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29626788/decrease-in-the-prevalence-of-extended-spectrum-cephalosporin-resistant-salmonella-following-cessation-of-ceftiofur-use-by-the-japanese-poultry-industry
#2
Hiroaki Shigemura, Mari Matsui, Tsuyoshi Sekizuka, Daisuke Onozuka, Tamie Noda, Akifumi Yamashita, Makoto Kuroda, Satowa Suzuki, Hirokazu Kimura, Shuji Fujimoto, Kazunori Oishi, Nobuyuki Sera, Yasuo Inoshima, Koichi Murakami
Extended-spectrum cephalosporin (ESC)-resistant Salmonella in chicken meat is a significant food safety concern. We previously reported that the prevalence of ESC-resistant Salmonella in chicken meat, giblets, and processed chicken (chicken meat products) increased in Japan between 2005 and 2010, with 27.9% (17/61) of Salmonella isolated from chicken meat products in 2010 showing resistance to ESC. The aims of the present study were to clarify trends in the prevalence of ESC-resistant Salmonella in chicken meat products in Japan between 2011 and 2015, and to determine the genetic profiles of bla-harboring plasmids, including replicon types, using next-generation sequencing...
March 17, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29562325/the-2018-european-heart-rhythm-association-practical-guide-on-the-use-of-non-vitamin-k-antagonist-oral-anticoagulants-in-patients-with-atrial-fibrillation
#3
Jan Steffel, Peter Verhamme, Tatjana S Potpara, Pierre Albaladejo, Matthias Antz, Lien Desteghe, Karl Georg Haeusler, Jonas Oldgren, Holger Reinecke, Vanessa Roldan-Schilling, Nigel Rowell, Peter Sinnaeve, Ronan Collins, A John Camm, Hein Heidbüchel
The current manuscript is the second update of the original Practical Guide, published in 2013 [Heidbuchel et al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation. Europace 2013;15:625-651; Heidbuchel et al. Updated European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist anticoagulants in patients with non-valvular atrial fibrillation. Europace 2015;17:1467-1507]. Non-vitamin K antagonist oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with atrial fibrillation (AF) and have emerged as the preferred choice, particularly in patients newly started on anticoagulation...
March 17, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29499359/statin-utilization-and-lipid-goal-attainment-in-high-or-very-high-cardiovascular-risk-patients-insights-from-italian-general-practice
#4
Marcello Arca, David Ansell, Maurizio Averna, Francesca Fanelli, Katherine Gorcyca, Şerban R Iorga, Aldo P Maggioni, Georges Paizis, Radovan Tomic, Alberico L Catapano
BACKGROUND AND AIMS: Statin utilization and lipid goal achievement were estimated in a large sample of Italian patients at high/very-high cardiovascular (CV) risk. METHODS: Patients aged ≥18 years with a valid low-density lipoprotein cholesterol (LDL-C) measurement in 2015 were selected from the IMS Health Real World Data database; non-high-density lipoprotein cholesterol (non-HDL-C) was assessed in those with available total cholesterol measurements. Index dates were defined as the last valid lipid measurement in 2015...
February 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29457358/crt-survey-ii-a-european-society-of-cardiology-survey-of-cardiac-resynchronisation-therapy-in-11-088-patients-who-is-doing-what-to-whom-and-how
#5
Kenneth Dickstein, Camilla Normand, Angelo Auricchio, Nigussie Bogale, John G Cleland, Anselm K Gitt, Christoph Stellbrink, Stefan D Anker, Gerasimos Filippatos, Maurizio Gasparini, Gerhard Hindricks, Carina Blomström Lundqvist, Piotr Ponikowski, Frank Ruschitzka, Giovanni Luca Botto, Alan Bulava, Gabor Duray, Carsten Israel, Christophe Leclercq, Peter Margitfalvi, Óscar Cano, Chris Plummer, Nedim Umutay Sarigul, Maciej Sterlinski, Cecilia Linde
BACKGROUND: Cardiac resynchronisation therapy (CRT) reduces morbidity and mortality in appropriately selected patients with heart failure and is strongly recommended for such patients by guidelines. A European Society of Cardiology (ESC) CRT survey conducted in 2008-2009 showed considerable variation in guideline adherence and large individual, national and regional differences in patient selection, implantation practice and follow-up. Accordingly, two ESC associations, the European Heart Rhythm Association and the Heart Failure Association, designed a second prospective survey to describe contemporary clinical practice regarding CRT...
February 19, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29407088/programmed-ventricular-stimulation-predicts-arrhythmic-events-and-survival-in-hypertrophic-cardiomyopathy
#6
Konstantinos A Gatzoulis, Stavros Georgopoulos, Christos-Konstantinos Antoniou, Aris Anastasakis, Polychronis Dilaveris, Petros Arsenos, Skevos Sideris, Dimitris Tsiachris, Stefanos Archontakis, Elias Sotiropoulos, Artemisia Theopistou, Ioannis Skiadas, Ioannis Kallikazaros, Christodoulos Stefanadis, Dimitrios Tousoulis
BACKGROUND: Sudden cardiac death (SCD) risk stratification in hypertrophic cardiomyopathy (HCM) in the context of primary prevention remains suboptimal. The purpose of this study was to examine the additional contribution of programmed ventricular stimulation (PVS) on established risk assessment. METHODS: Two-hundred-and-three consecutive patients with diagnosed HCM and ≥1 noninvasive risk factors were prospectively enrolled over 19years. Patients were risk stratified, submitted to PVS and received an implantable cardioverter-defibrillator (ICD) according to then-current American Heart Association (AHA) guidelines and inducibility...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29285144/icaritin-inhibits-decidualization-of-endometrial-stromal-cells
#7
Aiwen Le, Zhong Hai Wang, Xiao Yun Dai, Tian Hui Xiao, Rong Zhuo, Baozhen Zhang, Zhonglin Xiao, Xiujun Fan
The aim of the present study was to investigate the effects of Icaritin on the proliferation and decidualization of endometrial stromal cells (ESCs). A total of 20 specimens of endometrium were collected during hysterectomy at the Gynecology Department of Shenzhen Nanshan People's Hospital (Shenzhen, China) between August 2014 and December 2015. The endometrium was digested with high concentrations of collagenase and DNase and filtered with meshes, and then the glandular epithelial and stromal cells were separated by the adhesion purification method...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29230658/guidelines-in-review-comparison-of-the-2014-aha-acc-guideline-for-the-management-of-patients-with-non-st-elevation-acute-coronary-syndromes-and-the-2015-esc-guidelines-for-the-management-of-acute-coronary-syndromes-in-patients-presenting-without-persistent
#8
Shane P Prejean, Munaib Din, Eliana Reyes, Fadi G Hage
In this Guidelines in Review, we review side-by-side the recommendations provided by the 2014 AHA/ACC Guideline for the management of patients with non-ST-elevation acute coronary syndromes and the 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. We review the recommendations for imaging in the evaluation of patients with possible ACS followed by the diagnostic evaluation of patients with proven NSTE-ACS, based on their risk for adverse clinical events...
December 11, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29182745/unmet-need-for-primary-prevention-in-individuals-with-hypertriglyceridaemia-not-eligible-for-statin-therapy-according-to-european-society-of-cardiology-european-atherosclerosis-society-guidelines-a-contemporary-population-based-study
#9
Christian M Madsen, Anette Varbo, Børge G Nordestgaard
Aims: To identify individuals at high risk of atherosclerotic cardiovascular disease (ASCVD), who are not definite statin eligible according to the 2016 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines, based on high concentrations of plasma triglycerides. Methods and results: From the Copenhagen General Population Study (2003-2015) 58 547 individuals aged 40-65 and free of ASCVD, diabetes, and statin use at baseline were included...
February 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29182725/genomic-epidemiology-and-antimicrobial-resistance-of-neisseria-gonorrhoeae-in-new-zealand
#10
Robyn S Lee, Torsten Seemann, Helen Heffernan, Jason C Kwong, Anders Gonçalves da Silva, Glen P Carter, Rosemary Woodhouse, Kristin H Dyet, Dieter M Bulach, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson
Background: Antimicrobial-resistant Neisseria gonorrhoeae is a major threat to public health. No studies to date have examined the genomic epidemiology of gonorrhoea in the Western Pacific Region, where the incidence of gonorrhoea is particularly high. Methods: A population-level study of N. gonorrhoeae in New Zealand (October 2014 to May 2015). Comprehensive susceptibility testing and WGS data were obtained for 398 isolates. Relatedness was inferred using phylogenetic trees, and pairwise core SNPs...
February 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29129257/temporal-changes-in-infective-endocarditis-guidelines-during-the-last-12-years-high-level-evidence-needed
#11
Lauge Østergaard, Nana Valeur, Henning Bundgaard, Jawad H Butt, Nikolaj Ihlemann, Lars Køber, Emil L Fosbøl
BACKGROUND: Infective endocarditis (IE) is a complex disease necessitating extensive clinical guidelines. The guidelines from the American Heart Association (AHA) and the European Society of Cardiology (ESC) have been markedly extended during the last 12 years. We examined the evidence base for these changes. METHODS: IE guidelines published by AHA and ESC were reviewed. We categorized and combined guidelines into 3 time periods: (1) 2004 (AHA) and 2005 (ESC), (2) 2007 (AHA) and 2009 (ESC), and (3) 2015 (AHA) and 2015 (ESC)...
November 2017: American Heart Journal
https://www.readbyqxmd.com/read/29096615/control-of-cardiovascular-risk-factors-and-its-determinants-in-the-general-population-findings-from-the-staab-cohort-study
#12
Theresa Tiffe, Martin Wagner, Viktoria Rücker, Caroline Morbach, Götz Gelbrich, Stefan Störk, Peter U Heuschmann
BACKGROUND: While data from primary care suggest an insufficient control of vascular risk factors, little is known about vascular risk factor control in the general population. We therefore aimed to investigate the adoption of adequate risk factor control and its determinants in the general population free of cardiovascular disease (CVD). METHODS: Data from the Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression (STAAB) Cohort Study, a population-based study of inhabitants aged 30 to 79 years from the general population of Würzburg (Germany), were used...
November 2, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29066040/the-value-of-three-dimensional-photogrammetry-in-isolated-sagittal-synostosis-impact-of-age-and-surgical-technique-on-intracranial-volume-and-cephalic-index%C3%A2-a-retrospective-cohort-study
#13
Christian Mertens, Eline Wessel, Moritz Berger, Oliver Ristow, Jürgen Hoffmann, Katinka Kansy, Christian Freudlsperger, Heidrun Bächli, Michael Engel
PURPOSE: The aim of this study was to compare the outcome of intracranial volume (ICV) and cephalic index (CI) between two different techniques for surgical therapy of sagittal synostosis. MATERIAL AND METHODS: Between 2011 and 2015, all patients scheduled for surgical therapy of sagittal synostosis were consecutively enrolled. All patients younger than 6 months underwent early extended strip craniectomy (ESC group), and patients older than 6 months underwent late modified pi-procedure (MPP group)...
December 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29061222/international-multicentre-randomised-controlled-trial-of-improvisational-music-therapy-for-children-with-autism-spectrum-disorder-time-a-study
#14
Mike J Crawford, Christian Gold, Helen Odell-Miller, Lavanya Thana, Sarah Faber, Jörg Assmus, Łucja Bieleninik, Monika Geretsegger, Claire Grant, Anna Maratos, Stephan Sandford, Amy Claringbold, Helen McConachie, Morag Maskey, Karin Antonia Mössler, Paul Ramchandani, Angela Hassiotis
BACKGROUND: Preliminary studies have indicated that music therapy may benefit children with autism spectrum disorders (ASD). OBJECTIVES: To examine the effects of improvisational music therapy (IMT) on social affect and responsiveness of children with ASD. DESIGN: International, multicentre, three-arm, single-masked randomised controlled trial, including a National Institute for Health Research (NIHR)-funded centre that recruited in London and the east of England...
October 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28948472/farmers-breeding-practices-and-traits-of-economic-importance-for-indigenous-chicken-in-rwanda
#15
J Mahoro, T K Muasya, F Mbuza, J Mbuthia, A K Kahi
Data on breeding practices and traits of economic importance for the indigenous chicken (IC) were collected through personal interviews using structured questionnaires and direct observations of chicken management practices. The study was conducted from November 2015 to January 2016 in Rwamagana, Rulindo, Ruhango, Kicukiro and Muhanga districts of Rwanda. Data were collected and analysed through computation of indices, which represented a weighted average of all rankings of a specific trait. Spearman's non-parametric rank correlation was calculated for ranking of traits of economic importance to indicate the directional effects...
January 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28922233/endoscopic-versus-open-repair-for-craniosynostosis-in-infants-using-propensity-score-matching-to-compare-outcomes-a-multicenter-study-from-the-pediatric-craniofacial-collaborative-group
#16
Douglas R Thompson, David Zurakowski, Charles M Haberkern, Paul A Stricker, Petra M Meier, Carolyn Bannister, Hubert Benzon, Wendy Binstock, Adrian Bosenberg, Alyssa Brzenski, Stefan Budac, Veronica Busso, Samantha Capehart, Franklin Chiao, Franklyn Cladis, Michael Collins, Jordan Cusick, Rachel Dabek, Nicholas Dalesio, Ricardo Falcon, Allison Fernandez, Patrick Fernandez, John Fiadjoe, Meera Gangadharan, Katherine Gentry, Chris Glover, Susan Goobie, Heike Gries, Allison Griffin, Cornelius Botha Groenewald, John Hajduk, Rebecca Hall, Jennifer Hansen, Mali Hetmaniuk, Vincent Hsieh, Henry Huang, Pablo Ingelmo, Iskra Ivanova, Ranu Jain, Jeffrey Koh, Courtney Kowalczyk-Derderian, Jane Kugler, Kristen Labovsky, José Luis Martinez, Razaz Mujallid, Bridget Muldowney, Kim-Phuong Nguyen, Thanh Nguyen, Olutoyin Olutuye, Codruta Soneru, Timothy Petersen, Kim Poteet-Schwartz, Srijaya Reddy, Russell Reid, Karene Ricketts, Daniel Rubens, Rochelle Skitt, Lisa Sohn, Susan Staudt, Wai Sung, Tariq Syed, Peter Szmuk, Brad Taicher, Lisa Tetreault, Rheana Watts, Karen Wong, Vanessa Young, Lillian Zamora
BACKGROUND: The North American Pediatric Craniofacial Collaborative Group (PCCG) established the Pediatric Craniofacial Surgery Perioperative Registry to evaluate outcomes in infants and children undergoing craniosynostosis repair. The goal of this multicenter study was to utilize this registry to assess differences in blood utilization, intensive care unit (ICU) utilization, duration of hospitalization, and perioperative complications between endoscopic-assisted (ESC) and open repair in infants with craniosynostosis...
March 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28919197/imported-poultry-meat-as-a-source-of-extended-spectrum-cephalosporin-resistant-cmy-2-producing-salmonella-heidelberg-and-salmonella-minnesota-in-the-european-union-2014-2015
#17
Joana Campos, Joana Mourão, Leonor Silveira, Margarida Saraiva, Cristina Belo Correia, Ana Paula Maçãs, Luísa Peixe, Patrícia Antunes
Extended-spectrum cephalosporin (ESC)-resistant Salmonella have been described at a low level in the EU, nevertheless the increasing importation of poultry meat could be an important source of epidemic strains carrying ESC resistance genes. This study evaluated ESC resistance and its genetic platform among Salmonella isolates from poultry meat products imported into Portugal as well as clonal relatedness of the isolates. All Salmonella isolates recovered from samples of fresh meat destined for import into the EU in the scope of Portuguese official border control (2014-2015) were studied...
January 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28871622/-heartfailurematters-org-an-educational-website-for-patients-and-carers-from-the-heart-failure-association-of-the-european-society-of-cardiology-objectives-use-and-future-directions
#18
Kim P Wagenaar, Frans H Rutten, Leonie Klompstra, Yusuf Bhana, Floor Sieverink, Frank Ruschitzka, Petar M Seferovic, Mitja Lainscak, Massimo F Piepoli, Berna D L Broekhuizen, Anna Strömberg, Tiny Jaarsma, Arno W Hoes, Kenneth Dickstein
AIMS: In 2007, the Heart Failure Association of the European Society of Cardiology (ESC) launched the information website heartfailurematters.org (HFM site) with the aim of creating a practical tool through which to provide advice and guidelines for living with heart failure to patients, their carers, health care professionals and the general public worldwide. The website is managed by the ESC at the European Heart House and is currently available in nine languages. The aim of this study is to describe the background, objectives, use, lessons learned and future directions of the HFM site...
September 4, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28853530/-novelties-in-pericardial-diseases-a-focused-review-of-the-latest-european-guidelines
#19
Alexander Fardman, Yehuda Adler
More than a decade has elapsed since the first international guidelines on the diagnosis and management of pericardial diseases were issued by the European Society of Cardiology (ESC) in 2004. Since then, significant advances have been made in this field due to several randomized double blinded controlled trials and also retrospective, as well as prospective, cohort studies that were conducted during this time frame. However, despite the amount of knowledge that has been accumulated, only Spanish and Brazilian national societies of cardiology have so far published national guidelines on the management of pericardial diseases...
August 2017: Harefuah
https://www.readbyqxmd.com/read/28791832/prognostic-factors-in-pulmonary-arterial-hypertension-literature-review
#20
REVIEW
Emilia Stępnowska, Ewa Lewicka, Alicja Dąbrowska-Kugacka, Paweł Miękus, Grzegorz Raczak
Pulmonary arterial hypertension is a disease that has a bad influence on the patient's prognosis. Recently, the possibility of therapy has dramatically changed. Nowadays, the treatment of this disease is concerned mainly with the pathophysiological target. In clinical practice, it is important to start therapy at the appropriate time, when the patient is qualified because of an unsatisfactory examination result or improve therapy when the patient is getting worse. The understanding of prognosis factors in pulmonary arterial hypertension is necessary, because it is used to determine the length of patients' life expectancy...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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