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https://www.readbyqxmd.com/read/29166760/clinical-characteristics-and-treatment-propensity-in-elderly-patients-aged-over-80-years-with-colorectal-cancer
#1
Yun Hwa Jung, Jae Young Kim, Yu Na Jang, Sang Hoon Yoo, Gyo Hui Kim, Kang Min Lee, In Kyu Lee, Su Mi Chung, In Sook Woo
Background/Aims: Elderly patients (≥ 80 years) with colorectal cancer (CRC) tend to avoid active treatment at the time of diagnosis despite of recent advances in treatment. The aim of this study was to determine treatment propensity of elderly patients aged ≥ 80 years with CRC in clinical practice and the impact of anticancer treatment on overall survival (OS). Methods: Medical charts of 152 elderly patients (aged ≥ 80 years) diagnosed with CRC between 1998 and 2012 were retrospectively reviewed...
November 24, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29166759/magnetic-resonance-imaging-assessed-synovial-and-bone-changes-in-hand-and-wrist-joints-of-rheumatoid-arthritis-patients
#2
Kyung-Ann Lee, Sang-Ho Min, Tae-Hyung Kim, Sang-Heon Lee, Hae-Rim Kim
Background/Aims: Magnetic resonance imaging (MRI) is a sensitive and useful method for the detection of synovitis and joint destruction in rheumatoid arthritis (RA) patients. However, the patterns of MRI-detected bone erosion, bone marrow edema (BME), synovitis, and tenosynovitis have received insufficient attention. Therefore, this study evaluated the patterns of bone erosion, BME, synovitis, and tenosynovitis, and calculated the RA-MRI score (RAMRIS) of patients with RA at the carpal and metacarpophalangeal (MCP) joints using MRI...
November 24, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29166673/factors-related-to-acupuncture-response-in-patients-with-chronic-severe-functional-constipation-secondary-analysis-of-a-randomized-controlled-trial
#3
Xingyue Yang, Yan Liu, Bing Liu, Liyun He, Zhishun Liu, Yanshi Yan, Jia Liu, Baoyan Liu
BACKGROUND: Acupuncture has been demonstrated to be effective and safe for chronic severe functional constipation (CSFC). However, which patients with CSFC will have a better response to acupuncture remains unclear. OBJECTIVE: To explore factors related to acupuncture response in patients with CSFC. METHODS: We performed a secondary analysis of a previous multicenter randomized controlled trial consisting of a 2-week run-in period, 8-week treatment, and 12-week follow-up without treatment in which patients with CSFC were randomly allocated to an electroacupuncture group or a sham electroacupuncture group...
2017: PloS One
https://www.readbyqxmd.com/read/29166665/meditation-experts-try-virtual-reality-mindfulness-a-pilot-study-evaluation-of-the-feasibility-and-acceptability-of-virtual-reality-to-facilitate-mindfulness-practice-in-people-attending-a-mindfulness-conference
#4
María V Navarro-Haro, Yolanda López-Del-Hoyo, Daniel Campos, Marsha M Linehan, Hunter G Hoffman, Azucena García-Palacios, Marta Modrego-Alarcón, Luis Borao, Javier García-Campayo
Regular mindfulness practice benefits people both mentally and physically, but many populations who could benefit do not practice mindfulness. Virtual Reality (VR) is a new technology that helps capture participants' attention and gives users the illusion of "being there" in the 3D computer generated environment, facilitating sense of presence. By limiting distractions from the real world, increasing sense of presence and giving people an interesting place to go to practice mindfulness, Virtual Reality may facilitate mindfulness practice...
2017: PloS One
https://www.readbyqxmd.com/read/29166552/vortioxetine-versus-placebo-in-major-depressive-disorder-comorbid-with-social-anxiety-disorder
#5
Michael R Liebowitz, Jason Careri, Kyra Blatt, Ann Draine, Junko Morita, Melissa Moran, Rita Hanover
BACKGROUND: Major Depressive Disorder (MDD) and Social Anxiety Disorder (SAD) are highly comorbid, yet the combined condition has not been subject to any placebo-controlled treatment trials. This study reports a trial of vortioxetine, an antidepressant that has also shown benefit in Generalized Anxiety Disorder (GAD), in patients meeting DSM-5 criteria for both MDD and SAD. METHODS: The study was a 12-week double-blind, placebo-controlled comparison of vortioxetine 10-20 mg/day or placebo administered on a 1:1 ratio...
November 22, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29166536/clinical-investigation-of-left-ventricular-pacing-using-coronary-sinus-in-patients-with-mechanical-prosthetic-tricuspid-valve-replacement
#6
Kelan Zha, Kaijun Cui, Xingbin Liu, Yuan Fang
BACKGROUND: Although transvenous right ventricular (RV) endocardial lead placement is routine practice in clinical pacing, RV inaccessibility in certain clinical situations mandates the search for other sites. HYPOTHESIS: This study is aimed to verify whether left ventricular lead through coronary sinus is safe and efficient. METHODS: Based on a retrospective analysis of a single-center series of 4 patients with inaccessibility for RV pacing, we report on the feasibility and reliability of coronary sinus (CS) pacing via left ventricular (LV) lead, which usually is used in cardiac resynchronization therapy...
November 22, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29166505/anogenital-warts-in-pediatric-population
#7
Miguel Costa-Silva, Inês Fernandes, Acácio Gonçalves Rodrigues, Carmen Lisboa
The approach to children with anogenital warts in the context of sexual abuse is a challenge in clinical practice. This study aims to review the current knowledge of anogenital warts in children, the forms of transmission, and the association with sexual abuse and to propose a cross-sectional approach involving all medical specialties. A systematic review of the literature was conducted in Portuguese and English from January 2000 to June 2016 using the ISI Web of Knowledge and PubMed databases. Children aged 12 years or younger were included...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166480/-impact-of-moderate-intellectual-disability-on-the-dynamics-and-quality-of-family-life-a-qualitative-clinical-study
#8
Rodrigo Victor Viana Tomaz, Vanessa de Arruda Santos, Lucimar Retto da Silva de Avó, Carla Maria Ramos Germano, Débora Gusmão Melo
This qualitative clinical study investigated the impact of moderate intellectual disability on family dynamics and quality of life. The data were collected using individual interviews with 15 mothers of children with intellectual disabilities, as a convenience sample, and examined with categorical thematic content analysis. The results were discussed using a comprehensive and interpretative approach. Analysis of the interviews showed that care for children with intellectual disabilities is centered on the mother, contributing to the change in family relations...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29166477/regional-differences-in-infection-control-conditions-in-a-sample-of-primary-health-care-services-in-brazil
#9
Mauro Henrique Nogueira Guimarães de Abreu, Vera Lúcia Silva Resende, Kyu Ha Lee, Antônio Thomaz Gonzaga da Matta-Machado, Jacqueline Rose Starr
International guidelines have pointed out the importance of the physical environment of health care facilities in preventing and controlling infection. We aimed to describe the physical environment of dental care facilities in Brazil in 2014, focusing on characteristics designed to control infections. Exactly 16,202 dental offices in the Brazilian Unified National Health System (SUS) participated in this survey. Trained researchers extracted information about the infection control characteristics of health facilities by using a structured instrument...
November 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29166353/what-is-the-impact-of-the-underserved-pathway-program-on-graduates-entering-an-underserved-family-medicine-residency-five-year-findings-from-the-university-of-washington-school-of-medicine
#10
Amanda Kost, David Evans, Sharon Dobie, Elizabeth Sanders
PURPOSE: More primary care physicians are needed in underserved areas of the United States. Prior research indicates that medical student experiences in underserved settings increase the likelihood they will practice in underserved areas; few studies have controlled for selection bias. This study aimed to estimate the effect of the University of Washington School of Medicine's (UWSOM's) longitudinal extracurricular experience, the Underserved Pathway (UP), on graduates' choice in entering a family medicine residency with underserved training opportunities...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29166352/more-learners-finite-resources-and-the-changing-landscape-of-procedural-training-at-the-bedside
#11
Michael A Gisondi, Linda Regan, Jeremy Branzetti, Laura R Hopson
There is growing competition for non-operative, procedural training in teaching hospitals, due to an increased number of individuals seeking to learn procedures from a finite number of appropriate teaching cases. Procedural training is required by students, post-graduate learners, and practicing providers who must maintain their skills. These learner groups are growing in size as the number of medical schools increase and advance practice providers expand their skills to include complex procedures. These various learner needs occur against a background of advancing therapeutic techniques that improve patient care, but also act to reduce the overall numbers of procedures available to learners...
November 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29166260/the-development-and-content-validation-of-a-multidisciplinary-evidence-based-wound-infection-prevention-and-treatment-guideline
#12
Sammy A Zakhary, Chris Davey, Rebecca Bari, Jordan Bean, Tyler Reber, Kathy Gallagher, Kara Couch, Jennifer Hurlow, Karen Laforet, Corrine McIssac, Karen Napier, Diana Vilar-Compte, Emily Zakhary, Michel Hermans, Laura Bolton
Acute and chronic wound infections create clinical, economic, and patient-centered challenges best met by multidisciplinary wound care teams providing consistent, valid, clinically relevant, safe, evidence-based management across settings. To develop an evidence-based wound infection guideline, PubMed, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature databases were searched from inception through August 1, 2017 using the terms (or synonyms) wound infection and risk factor, significant, diagnosis, prevention, treatment, or surveillance...
November 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/29166151/biomarkers-and-imaging-of-breast-cancer
#13
Olena Weaver, Jessica W T Leung
OBJECTIVE: The goals of this review are to provide background information on the definitions and applications of the general term "biomarker" and to highlight the specific roles of breast imaging biomarkers in research and clinical breast cancer care. A search was conducted of the main electronic biomedical databases (PubMed, Cochrane, Embase, MEDLINE [Ovid], Scopus, and Web of Science). The search was focused on review literature in general radiology and biomedical sciences and on reviews and primary research articles on biomarkers in breast imaging over the 15 years ending in June 2017...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29166132/imaging-of-iatrogenic-esophageal-injuries-using-optimized-ct-esophageal-leak-protocol-pearls-and-pitfalls
#14
Rachna Madan, Olga Laur, Breland Crudup, Latia Peavy, Brett W Carter
Iatrogenic injury to the esophagus is a serious complication which is increasingly seen in clinical practice secondary to expansion and greater acceptability of surgical and endoscopic esophageal procedures. Morbidity and mortality following such injury is high. This is mostly due to an inflammatory response to gastric contents in the mediastinum, and the negative intra-thoracic pressures that may further draw out esophageal contents into the mediastinum leading to mediastinitis. Subsequently, pulmonary complications such as pneumonia or abscess may ensue leading to rapid clinical deterioration...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29165964/preventing-intradialytic-hypotension-translating-evidence-into-practice
#15
Wendi Bradshaw, Paul N Bennett, Cherene Ockerby, Alison M Hutchinson, Peter G Kerr
Intradialytic hypotension (IDH) remains the most frequent severe side effect of hemodialysis. This prospective, exploratory study aimed to measure the compliance of an IDH prevention pathway and to identify the effects of pathway use on hypotension incidence. Additionally, the study explored barriers and facilitators to pathway implementation in five hemodialysis centers. Instituting an ultrafiltration pause decreased the odds of hypotensive episodes by 44% (OR = 0.56, 95% CI = 0.20 to 1.56, χ2 1 = 1.25, p = 0...
March 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165940/-use-of-clinical-practice-guidelines-in-medicine-what-s-new
#16
Oriane Aebischer, Mathilde Rochat, Marie Méan
Clinicians are confronted to an abundance of clinical practice guidelines (CPG). It has been proven for several pathologies that the use of guidelines improves quality of care by reducing mortality, the number of hospitalisations and the length of stay. Despite these proven benefits, adherence to CPGs remains low, mainly due to lack of awareness and familiarity with the guidelines, as well as lack of applicability and flexibility for elderly and comorbid patients. Since adherence to CPGs are influenced by their accessibility and format, informatics will certainly play an important role in the development and implementation of CPGs in the future...
November 22, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29165888/molecular-pathology-and-thyroid-fna
#17
REVIEW
D N Poller, S Glaysher
This review summarises molecular pathological techniques applicable to thyroid FNA. The molecular pathology of thyroid tumours is now fairly well understood. Molecular methods may be used as a rule-in test for diagnosis of malignancy in thyroid nodules, eg BRAF V600E point mutation, use of a seven-gene mutational panel (BRAF V600E, RAS genes, RET/PTC or PAX8/PPARG rearrangement), or as a comprehensive multigene next-generation sequencing panel, eg ThyroSeq v2. Molecular methods can also be applied as rule-out tests for malignancy in thyroid nodules, eg Afirma or ThyroSeq v2 or as markers of prognosis, eg TERT promoter mutation or other gene mutations including BRAF V600E, TP53 and AKT1, and as tests for newly defined tumour entities such as non-invasive follicular thyroid neoplasm with papillary like nuclei, or as a molecular marker(s) for targeted therapies...
December 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29165831/external-validation-of-the-ita-li-ca-prognostic-system-for-patients-with-hepatocellular-carcinoma-a-multicenter-cohort-study-hep-17-0903
#18
Mauro Borzio, Elena Dionigi, Angelo Rossini, Massimo Marignani, Rodolfo Sacco, Ilario De Sio, Emanuela Bertolini, Giampiero Francica, Anna Giacomin, Giancarlo Parisi, Susanna Vicari, Anna Toldi, Andrea Salmi, Sergio Boccia, Mario Mitra, Fabio Fornari
Several staging systems for HCC have been developed. BCLC is considered the best in predicting survival, although limitations have emerged. Recently the Italian-Liver-Cancer (ITA.LI.CA) prognostic system, integrating the ITA.LI.CA tumor-staging (stages 0, A, B1-3; C) with Child-Pugh score, ECOG-PST, and AFP with a strong ability to predict survival was proposed. Aim of our study was to provide an external validation of the ITA.LI.CA system in an independent real-life occidental cohort of HCCs. METHODS: From September 2008 to April 2016, 1508 cirrhotics with incident HCC were consecutively enrolled in 27 Italian institutions (EpaHCC multi-institutional cohort)...
November 22, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29165800/generic-versions-of-narrow-therapeutic-index-drugs-a-national-survey-of-pharmacists-substitution-beliefs-and-practices
#19
Ameet Sarpatwari, Moa P Lee, Joshua J Gagne, Zhigang Lu, Sarah K Dutcher, Wenlei Jiang, Eric G Campbell, Aaron S Kesselheim
Small changes in bioavailability of narrow therapeutic index (NTI) drugs can alter clinical outcomes, raising concern over generic NTI substitution. We surveyed pharmacists to identify their perceptions of generic NTI drugs, their frequency of performing generic NTI substitution, and predictors of this behavior. Of 710 respondents (33% response rate), 87% perceived generic NTI drugs as effective as their brand-name versions and 94% as safe. Whereas 82% almost always performed generic NTI substitution for initial prescriptions, only 60% did for refills...
November 22, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29165784/interventions-for-managing-skeletal-muscle-spasticity-following-traumatic-brain-injury
#20
REVIEW
Anneliese Synnot, Marisa Chau, Veronica Pitt, Denise O'Connor, Russell L Gruen, Jason Wasiak, Ornella Clavisi, Loyal Pattuwage, Kate Phillips
BACKGROUND: Skeletal muscle spasticity is a major physical complication resulting from traumatic brain injury (TBI), which can lead to muscle contracture, joint stiffness, reduced range of movement, broken skin and pain. Treatments for spasticity include a range of pharmacological and non-pharmacological interventions, often used in combination. Management of spasticity following TBI varies from other clinical populations because of the added complexity of behavioural and cognitive issues associated with TBI...
November 22, 2017: Cochrane Database of Systematic Reviews
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