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https://www.readbyqxmd.com/read/29334908/self-reported-genital-warts-among-sexually-active-university-students-a-cross-sectional-study
#1
Silvia Cocchio, Chiara Bertoncello, Tatjana Baldovin, Alessandra Buja, Silvia Majori, Vincenzo Baldo
BACKGROUND: Genital warts are one of the most common forms of sexually-transmitted disease, but their epidemiology has yet to be thoroughly elucidated. The present study was designed to shed light on the prevalence of clinically-confirmed, self-reported genital warts (GWs) in a representative sample of the university population. METHODS: In 2015, a cross-sectional survey was conducted on 11,096 individuals approached at the Students Information Bureau where they came to enroll for a university degree course...
January 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29331245/outsmart-hpv-acceptability-and-short-term-effects-of-a-web-based-hpv-vaccination-intervention-for-young-adult-gay-and-bisexual-men
#2
Annie-Laurie McRee, Abigail Shoben, Jose A Bauermeister, Mira L Katz, Electra D Paskett, Paul L Reiter
BACKGROUND: Effective interventions to promote human papillomavirus (HPV) vaccination are needed, particularly among populations at increased risk of HPV-related disease. We developed and pilot tested a web-based intervention, Outsmart HPV, to promote HPV vaccination among young gay and bisexual men (YGBM). METHODS: In 2016, we recruited a national sample (n = 150) of YGBM ages 18-25 in the United States who had not received any doses of HPV vaccine. Participants were randomized to receive either standard HPV vaccination information (control) or population-targeted, individually-tailored content (Outsmart HPV intervention)...
January 10, 2018: Vaccine
https://www.readbyqxmd.com/read/29315288/the-promise-of-immunotherapy-in-anal-squamous-cell-carcinoma-a-novel-approach-for-an-orphan-disease
#3
Benny Johnson, Cathy Eng
An estimated 8200 men and women in the United States will receive a diagnosis of squamous cell carcinoma of the anal canal (SCCA) in 2017. Although SCCA is rare, accounting for 2.6% of gastrointestinal cancers, its incidence rate has been steadily increasing over the last few decades in the United States and around the world. More than 90% of cases of SCCA occur in the context of prior human papillomavirus (HPV) infection. To date, preventive vaccinations against HPV remain markedly underutilized. Most patients who have SCCA present with locoregional disease that is cured with chemoradiation...
December 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29310590/oral-human-papillomavirus-dna-detection-in-hiv-positive-men-prevalence-predictors-and-co-occurrence-at-anal-site
#4
Alessandra Vergori, Anna Rosa Garbuglia, Pierluca Piselli, Franca Del Nonno, Catia Sias, Federico Lupi, Daniele Lapa, Andrea Baiocchini, Claudia Cimaglia, Marco Gentile, Andrea Antinori, Maria Capobianchi, Adriana Ammassari
BACKGROUND: HIV-positive patients carry an increased risk of HPV infection and associated cancers. Therefore, prevalence and patterns of HPV infection at different anatomical sites, as well as theoretical protection of nonavalent vaccine should be investigated. Aim was to describe prevalence and predictors of oral HPV detection in HIV-positive men, with attention to nonavalent vaccine-targeted HPV types. Further, co-occurrence of HPV DNA at oral cavity and at anal site was assessed. METHODS: This cross-sectional, clinic-based study included 305 HIV-positive males (85...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29299683/hpv-genotypes-detected-by-linear-array-and-next-generation-sequencing-in-anal-samples-from-hiv-positive-men-who-have-sex-with-men-in-mexico
#5
Luz A González-Hernández, María G Flores-Miramontes, Adriana Aguilar-Lemarroy, Krissya S Quintanilla-Peña, Fabiola L Martin-Amaya-Barajas, Moisés Ramos-Solano, Luis F Enciso Gómez, Jaime F Andrade-Villanueva, Luis F Jave-Suárez
The incidence of anal cancer has been rising, especially in HIV+ patients and has been associated with HPV infection. HIV+ patients are more at risk of HPV coinfection and are seven times more likely to have persistent HPV infection; moreover, HIV+ men have an increased risk of developing anal cancer compared to HIV+ women. The development of screening strategies for the detection of HPV in HIV+ men is of major importance; however, there is not enough information about the HPV genotypes and variants that are colonizing the anal epithelia of HIV+ men in diverse geographical regions...
January 3, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29299360/prognostic-relevance-of-human-papillomavirus-infection-in-anal-squamous-cell-carcinoma-analysis-of-the-national-cancer-data-base
#6
Jaymin Jhaveri, Lael Rayfield, Yuan Liu, Mudit Chowdhary, Richard J Cassidy, Nicholas A Madden, Daniel G Tanenbaum, Theresa W Gillespie, Pretesh R Patel, Kirtesh R Patel, Jerome C Landry
Background: To examine the prognostic relevance of human papillomavirus (HPV) infection for anal squamous cell carcinoma (ASCC) patients treated with chemoradiation (CRT) in the National Cancer Data Base (NCDB). Methods: The 2014 NCDB was queried for non-metastatic, histologically confirmed, ASCC patients diagnosed between 2004 and 2013. Patients were required to have HPV status documented in order to be eligible. Patients were then stratified into two groups: HPV+ and HPV-...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29290288/differences-in-incidence-and-survival-of-oral-cavity-and-pharyngeal-cancers-between-germany-and-the-united-states-depend-on-the-hpv-association-of-the-cancer-site
#7
L Jansen, N Buttmann-Schweiger, S Listl, M Ressing, B Holleczek, A Katalinic, S Luttmann, K Kraywinkel, H Brenner
INTRODUCTION: The epidemiology of squamous cell oral cavity and pharyngeal cancers (OCPC) has changed rapidly during the last years, possibly due to an increase of human papilloma virus (HPV) positive tumors and successes in tobacco prevention. Here, we compare incidence and survival of OCPC by HPV-relation of the site in Germany and the United States (US). MATERIALS AND METHODS: Age-standardized and age-specific incidence and 5-year relative survival was estimated using data from population-based cancer registries in Germany and the US Surveillance Epidemiology and End Results (SEER) 13 database...
January 2018: Oral Oncology
https://www.readbyqxmd.com/read/29276162/hpv-unvaccinated-status-and-hpv-sexual-risk-behaviour-are-common-among-canadian-young-adult-women-and-men
#8
Melanie Zimmermann, Taylor Kohut, William A Fisher
OBJECTIVE: The current research focuses on sexual risk behaviour among young adult Canadians who have not been vaccinated against HPV. METHODS: Six hundred and forty-six Canadian university undergraduates completed a self-administered survey assessing HPV vaccination status and sexual risk behaviour. RESULTS: Five hundred and thirty-seven participants (154 men and 383 women aged 17-23) who met eligibility criteria were analyzed. 48.5% (n = 185) of female and 89...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29241719/nativity-disparities-in-human-papillomavirus-vaccination-among-u-s-adults
#9
Ashley E Pérez, Madina Agénor, Kristi E Gamarel, Don Operario
INTRODUCTION: Several studies have identified disparities in human papillomavirus (HPV)-related outcomes by nativity status (i.e., U.S.- versus foreign-born). However, few studies have explored whether vaccination differences exist by nativity status. Vaccination disparities have the potential to exacerbate HPV-related cancer disparities in the long term if left unaddressed. Therefore, the authors investigated whether there were significant differences in HPV vaccination initiation (one or more doses) and completion (three or more doses) between U...
December 11, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29216355/prevalence-of-and-risk-factors-for-anal-hpv-among-a-sample-of-predominantly-black-men-who-have-sex-with-men-in-houston-texas
#10
Alan G Nyitray, Kayo Fujimoto, Jing Zhao, Anna R Giuliano, John A Schneider, Lu-Yu Hwang
Introduction: Young men who have sex with men (MSM) are at increased risk for human papillomavirus (HPV)-associated disease as a result of HPV infection. Our objective was to characterize high-risk anal HPV prevalence, and factors associated with prevalence, among a group of young, primarily black, MSM in Houston, Texas. Background: Young MSM, aged 18-29 years, were recruited using a respondent-driven sampling method to study HIV/STD transmission and risk. The current analysis estimated HPV prevalence among 135 primarily young black MSM who engaged in peer recruitment chains and who self-collected anal exfoliated cells...
December 5, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29211874/prevalence-incidence-and-clearance-of-anal-high-risk-human-papillomavirus-hpv-infection-among-hiv-infected-men-in-the-sun-study
#11
Pragna Patel, Tim Bush, Erna Milunka Kojic, Lois Conley, Elizabeth R Unger, Teresa M Darragh, Keith Henry, John Hammer, Gerome Escota, Joel M Palefsky, John T Brooks
Background: The natural history of anal HPV infection among HIV-infected men is unknown. Methods: We collected anal swabs for cytology, HPV detection, and genotyping at annual visits from 2004-2012. We examined baseline prevalence, incidence and clearance of anal HPV infection at 48 months, and associated factors among HIV-infected men. Results: We examined 403 men who have sex with men (MSM) and 96 men who have sex with women (MSW) (median age 42 years for both, 87 vs...
December 4, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29211620/safety-profile-of-the-9-valent-human-papillomavirus-vaccine-assessment-in-prior-quadrivalent-hpv-vaccine-recipients-and-in-men-16-to-26%C3%A2-years-of-age
#12
E D Moreira, A R Giuliano, J de Hoon, O-E Iversen, E A Joura, J Restrepo, P Van Damme, C Vandermeulen, M C Ellison, A Krick, C Shields, B Heiles, A Luxembourg
A 9-valent HPV (9vHPV) vaccine has been developed to protect against HPV type 6/11/16/18/31/33/45/52/58-related infection and disease. Previous safety analyses from 7 clinical trials conducted in 9vHPV vaccine recipients 9-26 years of age, including comparisons of 9vHPV and quadrivalent HPV (qHPV) vaccines in girls and women 16-26 years of age, showed that the 9vHPV vaccine was generally well tolerated. Additional safety analyses were conducted to include the results of new clinical studies. The safety profile of the 9vHPV vaccine in prior qHPV vaccine recipients (n = 3756 from 1 randomized controlled trial and 2 open-label extension studies) and young men (n = 248 9vHPV and n = 248 qHPV vaccine recipients from 1 randomized controlled trial) was evaluated...
December 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29208707/recurring-infection-with-ecologically-distinct-hpv-types-can-explain-high-prevalence-and-diversity
#13
Sylvia L Ranjeva, Edward B Baskerville, Vanja Dukic, Luisa L Villa, Eduardo Lazcano-Ponce, Anna R Giuliano, Greg Dwyer, Sarah Cobey
The high prevalence of human papillomavirus (HPV), the most common sexually transmitted infection, arises from the coexistence of over 200 genetically distinct types. Accurately predicting the impact of vaccines that target multiple types requires understanding the factors that determine HPV diversity. The diversity of many pathogens is driven by type-specific or "homologous" immunity, which promotes the spread of variants to which hosts have little immunity. To test for homologous immunity and to identify mechanisms determining HPV transmission, we fitted nonlinear mechanistic models to longitudinal data on genital infections in unvaccinated men...
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29208455/high-prevalence-and-incidence-of-hpv-related-anal-cancer-precursor-lesions-in-hiv-positive-women-in-the-late-haart-era
#14
Carmen Hidalgo-Tenorio, Samantha E de Jesus, Javier Esquivias, Juan Pasquau
INTRODUCTION: Anal cancer is one of the most common non-AIDS defining malignancies, especially in men who have sex with men and women living with HIV (WLHIV). OBJECTIVES: To evaluate the prevalence and incidence of precursor lesions (high-grade squamous intraepithelial lesions [HSIL]) and anal cancer in our cohort of women and to compare them to cervical lesions; to calculate the percentage of patients that acquire and clear oncogenic genotypes (HR-HPV) in the anal canal; and to determine predictive factors for anal HPV infection...
December 2, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29205336/trends-in-incidence-mortality-and-survival-of-penile-squamous-cell-carcinoma-in-norway-1956-2015
#15
Bo T Hansen, Madleen Orumaa, A Kathrine Lie, Bjørn Brennhovd, Mari Nygård
We examine trends in incidence, mortality and survival of penile squamous cell carcinoma (SCC) in Norway over 60 years. Data on all cases of penile cancer diagnosed in Norway during 1956-2015 were obtained from the Cancer Registry of Norway. Trends in age-standardized rates of penile SCC incidence, mortality and 5-year relative survival were assessed by the annual percentage change statistic and joinpoint regression. A total of 1,596 penile cancer cases were diagnosed during 1956-2015, among which 1,474 (92...
December 4, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29204065/anal-cancer-and-anal-cancer-precursors-in-women-with-a-history-of-hpv-related-dysplasia-and-cancer
#16
Elizabeth A Stier, Elizabeth Y Chiao
The epidemiology of anal cancer in the U.S. has changed over the past 3 decades. During this period the incidence of anal cancer has increased among both men and women. Of note, women with a history of anogenital HPV infection are at higher risk than the general population for anal cancer. The increased risk ranged from increased incidence rate ratios ranging from 1.82 to 6.3 in women with a history of cervical cancer, to 4.2-16.4 in women with a history of prior cervical intraepithelial neoplasia 3 (CIN 3)...
June 2017: Seminars in Colon & Rectal Surgery
https://www.readbyqxmd.com/read/29186268/quality-of-life-in-men-diagnosed-with-anogenital-warts
#17
Caio Cavassan de Camargo, Maria Paula Barbieri D'Elia, Helio Amante Miot
Anogenital warts are a worldwide public health problem. They consist of epithelial proliferations caused by HPV, whose transmission occurs mainly through sexual intercourse. In this study, we evaluated their impact on the quality of life of adult males. We interviewed 88 men in an outpatient clinic for sexually transmitted diseases at a Brazilian public institution, using the DLQI-BRA questionnaire. Most patients (81%) presented mild or no impairment of quality of life. The main dimensions affected were sex life, symptoms, and embarrassment...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29184783/contemporary-role-of-radiotherapy-in-the-management-of-penile-cancer
#18
REVIEW
Martin Arthur Korzeniowski, Juanita Mary Crook
Penile cancer is a rare clinical entity that contributes to significant patient morbidity and mortality. Human papilloma virus (HPV) plays an important role in the carcinogenesis of penile squamous cell carcinoma (SCC), is associated with improved clinical outcomes, and is predictive for response to treatment with chemotherapy and radiotherapy. Historically, treatment consisted of radical surgery with partial or total penectomy. While effective for local control, surgical resection can impart significant physical, psychological and sexual dysfunction for afflicted men...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29184776/topical-therapy-for-non-invasive-penile-cancer-tis-updated-results-and-toxicity
#19
REVIEW
Aditya Manjunath, Thomas Brenton, Sarah Wylie, Catherine M Corbishley, Nick A Watkin
Penile cancer is a rare malignancy estimated to affect 26,000 men globally each year. The association with penile cancer, in particular non-invasive disease, and human papilloma virus (HPV) is well known. Ninety-five percent of cases of penile cancer are squamous cell carcinoma (SCC), which are staged using the TNM staging system. Terminology describing the histological appearance of non-invasive penile cancer has changed with all cases grouped under the umbrella term of penile intraepithelial neoplasia (PeIN); either undifferentiated or differentiated...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29184775/relationship-between-human-papillomavirus-and-penile-cancer-implications-for-prevention-and-treatment
#20
REVIEW
Laura C Kidd, Sharon Chaing, Juan Chipollini, Anna R Giuliano, Philippe E Spiess, Pranav Sharma
Penile cancer is a rare disease in the United States, but rates are increasing, causing concern. Several risk factors have been associated with the disease, including human papillomavirus (HPV) infection. Knowledge of HPV pathogenesis has led to the development of a vaccine, which has proven instrumental in reducing the incidence of female HPV-related cancers, but results in men have yet to be elucidated. Fortunately, rates of vaccination are up-trending in both males and females in the past several years. In addition, targeted therapies are the focus of several ongoing research efforts...
October 2017: Translational Andrology and Urology
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