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https://www.readbyqxmd.com/read/28328521/human-papillomavirus-first-and-second-generation-vaccines-current-status-and-future-directions
#1
Somayeh Pouyanfard, Martin Müller
It has been more than 10 years that the first prophylactic papillomavirus vaccine became available, although distribution has been mainly limited to the more affluent countries. The first two vaccines have been a great success, hundreds of millions of women and a much smaller number of men have been vaccinated ever since. In a few countries with high vaccination coverage, in particular Australia but also parts of Great Britain and others, clinical impact of vaccination programs is already visible and there are indications for herd immunity as well...
March 22, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28323757/the-performance-of-human-papillomavirus-biomarkers-in-predicting-anal-high-grade-squamous-intraepithelial-lesions-in-gay-and-bisexual-men
#2
Fengyi Jin, Jennifer M Roberts, Andrew E Grulich, I Mary Poynten, Dorothy A Machalek, Alyssa Cornall, Samuel Phillips, Deborah Ekman, Ross L Mcdonald, Richard J Hillman, David J Templeton, Annabelle Farnsworth, Suzanne M Garland, Christopher K Fairley, Sepehr N Tabrizi
BACKGROUND: We evaluate the performance of human papillomavirus (HPV) biomarkers in prediction of anal histological high-grade squamous intraepithelial lesions (HSIL) in gay and bisexual men (GBM) in Sydney, Australia. DESIGN: Baseline analysis of a three-year cohort study METHODS:: The Study of the Prevention of Anal Cancer (SPANC) is natural history study of anal HPV infection in GBM aged ≥35 years. All participants completed cytological and histological assessments...
March 18, 2017: AIDS
https://www.readbyqxmd.com/read/28323751/long-term-nitrite-inhalant-exposure-and-cancer-risk-in-men-who-have-sex-with-men-a-prospective-cohort-study
#3
Anupriya Dutta, Hajime Uno, Alex Holman, David R Lorenz, Steven M Wolinsky, Dana Gabuzda
OBJECTIVES: Nitrite inhalants (poppers) are commonly used recreational drugs among men who have sex with men (MSM) and were previously associated with elevated rates of high-risk sexual behavior, HIV and HHV-8 seroconversion, and transient immunosuppressive effects in experimental models. Whether long-term popper use is associated with cancer risk among MSM in the HAART era is unclear. DESIGN: Prospective cohort study of cancer risk in 3223 HIV-infected and -uninfected MSM in the Multicenter AIDS Cohort Study from 1996-2010...
March 18, 2017: AIDS
https://www.readbyqxmd.com/read/28316321/analyzing-esophageal-squamous-cell-papillomas-for-the-presence-of-human-papilloma-virus
#4
Arzu Tiftikçi, Eser Kutsal, Ender Altıok, Ümit İnce, Bahattin Çicek, Murat Saruç, Nurten Türkel, Özdal Ersoy, Güven Yenmiş, Nurdan Tözün
BACKGROUND/AIMS: Human Papilloma Virus (HPV) infection can be a predisposing condition for the development of squamous cell papilloma (SCP) of the esophagus, which can progress to dysplasia and to carcinoma as a result of chronic infection. The aim of the present study was to search for the presence of HPV in the esophageal SCP, and to genotype the detected HPV. MATERIALS AND METHODS: Data from patients with definite diagnosis of SCP of the esophagus were identified from pathology records for two years period at different Hospitals...
March 17, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28316071/chlamydia-trachomatis-and-hpv-co-infections-in-hiv-negative-men-from-a-multi-ethnic-area-of-northern-italy-at-high-prevalence-of-cervical-malignancies
#5
Manola Comar, Silva Seraceni, Claudia Colli, Viviana Luska, Sara Morassut, Libera Clemente, Marina Drabeni, Gianmichele Moise, Francesco Fontana, Lorenzo Monasta, Barbara Suligoi
Chlamydia trachomatis and HPV coinfections in the male population are often a disregarded issue. We performed a study to evaluate the prevalence of such infections in heterosexual HIV negative men from a Northern Italy multi-ethnic area at high prevalence for cervical malignancies. Urethral swabs (US) or first-voided urine were evaluated retrospectively from 1317 patients attending Sexually Transmitted Infections (STI) clinic and from 3388 outpatients attending private clinics. Informations about participants' demographic characteristics and attributes of Chlamydia trachomatis, including chronic infection, and HPV genotypes testing, were collected...
March 18, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28301790/human-papillomavirus-vaccination-and-genital-warts-in-young-indigenous-australians-national-sentinel-surveillance-data
#6
Hammad Ali, Hamish McManus, Catherine C O'Connor, Denton Callander, Marlene Kong, Simon Graham, Dina Saulo, Christopher K Fairley, David G Regan, Andrew Grulich, Nicola Low, Rebecca J Guy, Basil Donovan
OBJECTIVES: To examine the impact of the national human papillomavirus (HPV) vaccination program (available to girls and women [12-26 years] since 2007 and to boys [12-15 years] since 2013) on the number of diagnoses of genital warts in Australian Aboriginal and Torres Strait Islander (Indigenous) people. DESIGN, SETTING, PARTICIPANTS: Analysis of routinely collected data from patients attending 39 sexual health clinics (SHCs) in the Genital Warts Surveillance Network for the first time...
March 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28292201/performing-piety-in-sexual-health-research-gender-health-and-evangelical-christianities-in-a-mexican-human-papillomavirus-hpv-study
#7
Emily Wentzell
Recent research suggests that health surveillance experiences like clinical trial participation might have unanticipated social consequences. I investigate how evangelical Christians participating in longitudinal, observational sexual health research incorporate that long-term medical surveillance into their religious practice. This exploratory research focuses on Mexican Cristianos' participation in the Cuernavaca arm of the multinational 'Human Papillomavirus in Men' ('HIM') study, which tested men for the common and usually asymptomatic sexually transmitted infection human papillomavirus (HPV) over time...
March 15, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/28288596/needles-jabs-and-jags-a-qualitative-exploration-of-barriers-and-facilitators-to-child-and-adult-immunisation-uptake-among-gypsies-travellers-and-roma
#8
Cath Jackson, Helen Bedford, Francine M Cheater, Louise Condon, Carol Emslie, Lana Ireland, Philippa Kemsley, Susan Kerr, Helen J Lewis, Julie Mytton, Karen Overend, Sarah Redsell, Zoe Richardson, Christine Shepherd, Lesley Smith, Lisa Dyson
BACKGROUND: Gypsies, Travellers and Roma (referred to as Travellers) are less likely to access health services including immunisation. To improve immunisation rates, it is necessary to understand what helps and hinders individuals in these communities in taking up immunisations. This study had two aims. 1. Investigate the views of Travellers in the UK on the barriers and facilitators to acceptability and uptake of immunisations and explore their ideas for improving immunisation uptake; 2...
March 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28276945/using-community-engagement-to-develop-a-web-based-intervention-for-latinos-about-the-hpv-vaccine
#9
Julie A Maertens, Andrea M Jimenez-Zambrano, Karen Albright, Amanda F Dempsey
Human papillomavirus (HPV) infection is pervasive among sexually active women and men, and Hispanic women are at particularly high risk as they have higher rates of invasive cervical cancer compared to other racial or ethnic groups in the United States. There is a need for interventions to increase HPV vaccination among this high-risk population. This study investigated how to modify a previously developed web-based intervention that provided individually tailored information about HPV to improve its use among the Latino population...
February 22, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28261849/the-presence-of-human-papillomavirus-in-semen-does-not-affect-the-integrity-of-sperm-dna
#10
E I Cortés-Gutiérrez, M I Dávila-Rodríguez, J L Fernández, L O de la O-Pérez, M E Garza-Flores, R Eguren-Garza, J Gosálvez
It remains unknown whether human papillomaviruses (HPVs) in semen affect sperm DNA integrity. We investigated whether the presence of these viruses in semen was associated with an elevated sperm DNA fragmentation index. Semen samples of 22 normozoospermic patients undergoing infertility treatment, nine fertile donors and seven fertile men with a risk of HPV infection (genital warts or condylomas) were included in the study. The samples were examined by an INNO-LiPA test PCR-based reverse hybridisation array that identifies 28 types of HPVs as simple or multiple infections...
March 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28252530/risk-factors-of-high-grade-anal-intraepithelial-neoplasia-recurrence-in-hiv-infected-men-who-have-sex-with-men
#11
Joaquin Burgos, Adria Curran, Stefania Landolfi, Ana Guelar, Lucia Miguel, MCarmen Dinares, Judith Villar, Jordi Navarro, Javier Hernandez-Losa, Vicenç Falcó
OBJECTIVE: To assess risk factors of high-grade anal intraepithelial neoplasia (HGAIN) recurrence in a cohort of HIV-infected men who have sex with men (MSM). DESIGN AND METHODS: Consecutive HIV-infected 100 MSM with a history of successfully treated intra-anal HGAIN with electrocautery were followed with anal cytology, human papillomavirus (HPV) determination, and high-resolution anoscopy (HRA) at 3-6 month intervals. HGAIN recurrence was analyzed using Kaplan-Meier analysis...
March 1, 2017: AIDS
https://www.readbyqxmd.com/read/28249648/prevalence-of-human-papillomavirus-in-tonsil-brushings-and-gargles-in-cancer-free-patients-the-split-study
#12
Jean-Damien Combes, Véronique Dalstein, Tarik Gheit, Gary M Clifford, Massimo Tommasino, Christine Clavel, Jean Lacau St Guily, Silvia Franceschi
OBJECTIVE: To evaluate human papillomavirus (HPV) prevalence in the tonsil using extensive ex vivo brushing and gargling in a large age-stratified sample of cancer-free patients. MATERIALS AND METHODS: From 2012 to 2016, consecutive patients undergoing tonsillectomy for benign indications in 19 French University Hospitals were invited to participate in the SPLIT study. Immediately after resection, half-tonsils were extensively brushed at the pathology laboratories on the surface epithelium and in tonsil crypts to collect exfoliated cells...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28248020/-anogenital-warts-a-new-way-of-solving-the-common-problem-of-urology-results-of-long-term-follow-up
#13
A D Protasov, I S Lipatov, M P Kostinov, Yu V Tezikov, A D Shmitko, D V Pakhomov, D A Blagovidov, A V Zhestkov, A A Ryzhov, E V Vekhova
AIM: To evaluate the effectiveness of combined use of the imiquimod 5% cream and vaccination against human papillomavirus (HPV) using a quadrivalent recombinant vaccine to achieve long-term clinical remission of chronic HPV infection manifested by anogenital warts. MATERIAL AND METHODS: The study comprised 36 patients, including 22 men, aged 26.4+/-4.1 years, who had from 1 to 5 anogenital warts. Participants of the study were vaccinated by quadrivalent recombinant vaccine under a 3-dose scheme 0-2-6 months co-administered with imiquimod 5% cream three times per week up to 16 weeks...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28245234/hpv-vaccine-knowledge-and-acceptability-among-peruvian-men-who-have-sex-with-men-and-transgender-women-a-pilot-qualitative-study
#14
Jerome T Galea, Emmi Monsour, César R Nureña, Magaly M Blas, Brandon Brown
PURPOSE: Human papillomavirus (HPV) is the most common sexually transmitted infection globally and is responsible for a variety of cancers in men and women. An effective HPV vaccine licensed for use in girls and boys has been indicated for-but is not widely implemented in-men who have sex with men (MSM). Limited data are available for transgender women (TW). We explored the social and behavioral aspects related to HPV vaccine uptake and participation in HPV vaccine studies among Peruvian MSM and TW...
2017: PloS One
https://www.readbyqxmd.com/read/28241096/the-prognostic-role-of-sex-race-and-human-papillomavirus-in-oropharyngeal-and-nonoropharyngeal-head-and-neck-squamous-cell-cancer
#15
Carole Fakhry, William H Westra, Steven J Wang, Annemieke van Zante, Yuehan Zhang, Eleni Rettig, Linda X Yin, William R Ryan, Patrick K Ha, Alicia Wentz, Wayne Koch, Jeremy D Richmon, David W Eisele, Gypsyamber D'Souza
BACKGROUND: Human papillomavirus (HPV) is a well-established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and 2) patients with nonoropharyngeal (non-OP) head and neck squamous cell cancers (HNSCCs)...
February 27, 2017: Cancer
https://www.readbyqxmd.com/read/28239675/hpv16-e6-seropositivity-among-cancer-free-men-with-oral-anal-or-genital-hpv16-infection
#16
Daniel C Beachler, Tim Waterboer, Christine M Pierce Campbell, Donna J Ingles, Krystle A Lang Kuhs, Alan G Nyitray, Allan Hildesheim, Michael Pawlita, Aimée R Kreimer, Anna R Giuliano
Antibodies against the Human papillomavirus 16 (HPV16) E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. Serum samples from 173 cancer-free men from the Human Papillomavirus Infection in Men (HIM) Study were tested for HPV antibodies and DNA. HPV16 E6 seropositivity was low among men with oral HPV16-infection (1/28; 3.6%, 95%CI=0.0%-18.4%), anal HPV16-infection (1/61; 1.6%, 95%CI=0.0%-8.8%), and 24-month persistent genital HPV16-infection (1/84; 1...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/28229612/preliminary-results-of-a-screening-program-for-anal-cancer-and-its-precursors-for-hiv-infected-men-who-have-sex-with-men-in-vigo-spain
#17
Mauricio Iribarren Díaz, Antonio Ocampo Hermida, Joaquín González-Carreró Fojón, Rebeca Longueira Suárez, Alberto Rivera Gallego, Enrique Casal Núñez, Antón Ocampo Álvarez, Edward Cachay
BACKGROUND: Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (HPV) anal infection, and cytological and histological findings in a Spanish medium-size community (Vigo, Spain). METHOD: Prospective cohort analysis of 240 HIV-infected MSM...
February 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28220313/hiv-infected-young-men-demonstrate-appropriate-risk-perceptions-and-beliefs-about-safer-sexual-behaviors-after-human-papillomavirus-vaccination
#18
Jessica A Kahn, Jeannette Lee, Marvin Belzer, Joel M Palefsky
The aim of this study was to identify risk perceptions after human papillomavirus (HPV) vaccination among HIV-infected young men who have sex with men. On average, participants appropriately perceived themselves to be at lower than neutral risk for HPV (mean subscale score 4.2/10), at higher than neutral risk for other sexually transmitted infections (7.0/10), and that safer sexual behaviors were still important (8.5/10). Higher perceived risk of HPV was associated with African-American race (p = .03); higher perceived risk of other sexually transmitted infections with White race (p = ...
February 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28213874/disease-burden-of-human-papillomavirus-infection-in-the-netherlands-1989-2014-the-gap-between-females-and-males-is-diminishing
#19
Scott A McDonald, Venetia Qendri, Johannes Berkhof, Hester E de Melker, Johannes A Bogaards
PURPOSE: Besides cervical cancer, HPV infection is linked to a multitude of diseases in both males and females, suggesting that vaccination programmes should be re-evaluated, with a judicious assessment made of the disease burden stratified by sex, age, and genotype. Projections of burden into the near future are also needed to provide a benchmark for evaluating the impact of vaccination programmes, and to assess the need for scaling-up preventive measures. METHODS: Using the disability-adjusted life-years (DALY) measure, we estimated the total HPV-associated disease burden in the Netherlands...
March 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28210481/human-papillomavirus-hpv-virion-induced-cancer-and-subfertility-two-sides-of-the-same-coin
#20
REVIEW
T Depuydt, J Beert, E Bosmans, G Salembier
In the natural history of HPV infections, the HPV virions can induce two different pathways, namely the infec- tious virion producing pathway and the clonal transforming pathway. An overview is given of the burden that is associated with HPV infections that can both lead to cervical cancer and/or temporal subfertility. That HPV infections cause serious global health burden due to HPV-associated cancers is common knowledge, but that it is also responsible for a substantial part of idiopathic subfertility is greatly underestimated...
December 2016: Facts, Views & Vision in ObGyn
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