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https://www.readbyqxmd.com/read/28335557/ros-production-and-erk-activity-are-involved-in-the-effects-of-d-%C3%AE-hydroxybutyrate-and-metformin-in-a-glucose-deficient-condition
#1
Santosh Lamichhane, Tonking Bastola, Ramesh Pariyar, Eun-Sol Lee, Ho-Sub Lee, Dae Ho Lee, Jungwon Seo
Hypoglycemia, a complication of insulin or sulfonylurea therapy in diabetic patients, leads to brain damage. Furthermore, glucose replenishment following hypoglycemic coma induces neuronal cell death. In this study, we investigated the molecular mechanism underlying glucose deficiency-induced cytotoxicity and the protective effect of d-β-hydroxybutyrate (D-BHB) using SH-SY5Y cells. The cytotoxic mechanism of metformin under glucose deficiency was also examined. Cell viability under 1 mM glucose (glucose deficiency) was significantly decreased which was accompanied by increased production of reactive oxygen species (ROS) and decreased phosphorylation of extracellular signal-regulated kinase (ERK) and glycogen synthase 3 (GSK3β)...
March 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335291/multispectral-emissions-of-lanthanide-doped-gadolinium-oxide-nanophosphors-for-cathodoluminescence-and-near-infrared-upconversion-downconversion-imaging
#2
Doan Thi Kim Dung, Shoichiro Fukushima, Taichi Furukawa, Hirohiko Niioka, Takumi Sannomiya, Kaori Kobayashi, Hiroshi Yukawa, Yoshinobu Baba, Mamoru Hashimoto, Jun Miyake
Comprehensive imaging of a biological individual can be achieved by utilizing the variation in spatial resolution, the scale of cathodoluminescence (CL), and near-infrared (NIR), as favored by imaging probe Gd₂O₃ co-doped lanthanide nanophosphors (NPPs). A series of Gd₂O₃:Ln(3+)/Yb(3+) (Ln(3+): Tm(3+), Ho(3+), Er(3+)) NPPs with multispectral emission are prepared by the sol-gel method. The NPPs show a wide range of emissions spanning from the visible to the NIR region under 980 nm excitation. The dependence of the upconverting (UC)/downconverting (DC) emission intensity on the dopant ratio is investigated...
September 6, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335266/synthesis-of-p-co%C3%A2-o%C3%A2-n-tio%C3%A2-nanoparticles-for-overall-water-splitting-under-visible-light-irradiation
#3
Qiang Zhang, Zhenyin Hai, Aoqun Jian, Hongyan Xu, Chenyang Xue, Shengbo Sang
p-Co₃O₄/n-TiO₂ nanoparticles (~400 nm) for photocatalysis were prepared via carbon assisted method and sol-gel method in this work. The paper also studied the application of visible light illuminated p-Co₃O₄/n-TiO₂ nanocomposites cocatalyst to the overall pure water splitting into H₂ and O₂. In addition, the H₂ evolution rate of the p-Co₃O₄/n-TiO₂ nanocomposites is 25% higher than that of the pure Co₃O₄ nanoparticles. Besides, according to the results of the characterizations, the scheme of visible light photocatalytic water splitting is proposed, the Co₃O₄ of the nanocomposites is excited by visible light, and the photo-generated electrons and holes existing on the conduction band of Co₃O₄ and valence band of TiO₂ have endowed the photocatalytic evolution of H₂ and O₂ with higher efficiency...
July 27, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335232/the-influence-of-modified-silica-nanomaterials-on-adult-stem-cell-culture
#4
Luigi Tarpani, Francesco Morena, Marta Gambucci, Giulia Zampini, Giuseppina Massaro, Chiara Argentati, Carla Emiliani, Sabata Martino, Loredana Latterini
The preparation of tailored nanomaterials able to support cell growth and viability is mandatory for tissue engineering applications. In the present work, silica nanoparticles were prepared by a sol-gel procedure and were then functionalized by condensation of amino groups and by adsorption of silver nanoparticles. Transmission electron microscopy (TEM) imaging was used to establish the morphology and the average dimensions of about 130 nm, which were not affected by the functionalization. The three silica samples were deposited (1 mg/mL) on cover glasses, which were used as a substrate to culture adult human bone marrow-mesenchymal stem cells (hBM-MSCs) and human adipose-derived stem cells (hASCs)...
June 4, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334935/genome-wide-association-study-of-iron-traits-and-relation-to-diabetes-in-the-hispanic-community-health-study-study-of-latinos-hchs-sol-potential-genomic-intersection-of-iron-and-glucose-regulation
#5
Laura M Raffield, Tin Louie, Tamar Sofer, Deepti Jain, Eli Ipp, Kent D Taylor, George J Papanicolaou, Larissa Avilés-Santa, Leslie A Lange, Cathy C Laurie, Matthew P Conomos, Timothy A Thornton, Yii-Der Ida Chen, Qibin Qi, Scott Cotler, Bharat Thyagarajan, Neil Schneiderman, Jerome I Rotter, Alex P Reiner, Henry J Lin
Genetic variants contribute to normal variation of iron-related traits and may also cause clinical syndromes of iron deficiency or excess. Iron overload and deficiency can adversely affect human health. For example, elevated iron storage is associated with increased diabetes risk, although mechanisms are still being investigated. We conducted the first genome-wide association study (GWAS) of serum iron, total iron binding capacity (TIBC), transferrin saturation, and ferritin in a Hispanic/Latino cohort, the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; >12,000 participants) and also assessed the generalization of previously known loci to this population...
March 7, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28334101/refbool-a-reference-based-algorithm-for-discretizing-gene-expression-data
#6
Sascha Jung, Andras Hartmann, Antonio Del Sol
Motivation: The identification of genes or molecular regulatory mechanisms implicated in biological processes often requires the discretization, and in particular booleanization, of gene expression measurements. However, currently used methods mostly classify each measurement into an active or inactive state regardless of its statistical support possibly leading to downstream analysis conclusions based on spurious booleanization results. Results: In order to overcome the lack of certainty inherent in current methodologies and to improve the process of discretization, we introduce RefBool, a reference-based algorithm for discretizing gene expression data...
February 22, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28333065/preparation-of-mesoporous-tio2-with-enhanced-photocatalytic-activity-towards-tannery-wastewater-degradation
#7
Weiwei Zhao, Xiu He, Yu Peng, Hongfeng Zhang, Donglan Sun, Xiaocong Wang
Ordered mesoporous TiO2 materials are successfully synthesized via a sol-gel route using butyl titanate as a precursor and sodium dodecyl benzene sulfonate surfactants as soft templates. The as-prepared TiO2 samples possess a relatively high surface area of 40.03 m(2)/g and the center of pore diameter distribution of 13.04 nm. They exhibit excellent photocatalytic activity towards degradation of organic pollutants in tannery wastewater under UV-light and natural sunlight irradiation. The effect of the catalyst dosage, the pH value of the solution and the concentration of H2O2 are discussed in detail...
March 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28333055/enhanced-adsorption-removal-of-anionic-dyes-via-a-facile-preparation-of-amino-functionalized-magnetic-silica
#8
Xiao-Shui Li, Yu-Han Fan, Shou-Wen Zhang, Shi-Hua Qi
A novel amino-functionalized magnetic silica (Fe3O4@SiO2-NH2) was easily prepared via a one-step method integrating the immobilization of 3-aminopropyltriethoxysilane with a sol-gel process of tetraethyl orthosilicate into a single process. This showed significant improvement in the adsorption capacity of anionic dyes. The product (Fe3O4@SiO2-NH2) was characterized with scanning electron microscopy, Fourier transform infrared spectroscopy, energy dispersive X-ray spectrometry, zeta potential and vibrating sample magnetometry...
March 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28332482/development-of-novel-silk-fibroin-polyvinyl-alcohol-sol-gel-bioactive-glass-composite-matrix-by-modified-layer-by-layer-electrospinning-method-for-bone-tissue-construct-generation
#9
B N Singh, K Pramanik
The worldwide occurrence of bone tissue related defects as well as diseases and lack of successful perpetual cure has attracted attention and accelerated exploration of composite scaffolding material with superior bioactivity, osteoinductivity and osteoconductivity properties. Among such biomaterials, silk fibroin and bioglass composite attained special emphasis to develop tissue engineered construct with a hierarchical structure ranging from nano to microscale thereby mimicking bone tissue extracellular matrix...
March 23, 2017: Biofabrication
https://www.readbyqxmd.com/read/28331991/systematic-review-and-meta-analysis-of-adolescent-cognitive-behavioral-sleep-interventions
#10
REVIEW
Matthew J Blake, Lisa B Sheeber, George J Youssef, Monika B Raniti, Nicholas B Allen
This systematic review and meta-analysis examined the efficacy of adolescent cognitive-behavioral sleep interventions. Searches of PubMed, PsycINFO, CENTRAL, EMBASE, and MEDLINE were performed from inception to May 1, 2016, supplemented with manual screening. Nine trials were selected (n = 357, mean age = 14.97 years; female = 61.74%). Main outcomes were subjective (sleep diary/questionnaire) and objective (actigraphy) total sleep time (TST), sleep onset latency (SOL), sleep efficiency (SE), and wake after sleep onset (WASO)...
March 22, 2017: Clinical Child and Family Psychology Review
https://www.readbyqxmd.com/read/28329091/association-between-sleep-timing-obesity-diabetes-the-hispanic-community-health-study-study-of-latinos-hchs-sol-cohort-study-sleep-timing-obesity-and-diabetes
#11
Kristen L Knutson, Donghong Wu, Sanjay R Patel, Jose S Loredo, Susan Redline, Jianwen Cai, Linda C Gallo, Yasmin Mossavar-Rahmani, Alberto R Ramos, Yanping Teng, Martha L Daviglus, Phyllis C Zee
Study Objectives: Recent studies implicate inadequate sleep duration and quality in metabolic disease. Fewer studies have examined the timing of sleep, which may be important because of its potential impact on circadian rhythms of metabolic function. We examined the association between sleep timing and metabolic risk among Hispanic/Latino adults. Methods.: Cross-sectional data from community-based study of 13,429 participants aged 18-74 years. People taking diabetes medications were excluded...
January 28, 2017: Sleep
https://www.readbyqxmd.com/read/28327513/indoor-positioning-system-using-magnetic-field-map-navigation-and-an-encoder-system
#12
Han-Sol Kim, Woojin Seo, Kwang-Ryul Baek
In the indoor environment, variation of the magnetic field is caused by building structures, and magnetic field map navigation is based on this feature. In order to estimate position using this navigation, a three-axis magnetic field must be measured at every point to build a magnetic field map. After the magnetic field map is obtained, the position of the mobile robot can be estimated with a likelihood function whereby the measured magnetic field data and the magnetic field map are used. However, if only magnetic field map navigation is used, the estimated position can have large errors...
March 22, 2017: Sensors
https://www.readbyqxmd.com/read/28326726/-effects-of-different-surface-modifications-on-micro-structure-and-adhesion-of-zirconia-ceramic-an-in-vitro-study
#13
Li Siwen, Li Shishi, Wang Yanhong, Ma Hongmei
OBJECTIVE: This study evaluated the effect of different mechanical-chemical surface treatments on the characteristics, microstructure, and composition of zirconia ceramics and on the zirconia-dentin adhesion. METHODS: The sintered commercial zirconia blocks (IPS e.max ZirCAD) were sectioned into 126 beams (6 mm×6 mm×5 mm) and randomly assigned to seven experimental groups (n=18). The zirconia block specimens were further treated as follows: (A) untreated, as control; (B) sandblasted with 50 μm Al2O3; (C) sandblasted with 50 μm Al2O3+30 μm silica powder; (D) sandblasted with 50 μm Al2O3+30% silica-sol coating; (E) sandblasted with 110 μm Al2O3; (F) sandblasted with 110 μm Al2O3+30 μm silica powder; and (G) sandblasted with 110 μm Al2O3+30% silica-sol coating...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28326629/solvent-controlled-phase-transition-of-a-co-ii-organic-framework-from-achiral-to-chiral-and-two-to-three-dimen-sion
#14
Xing-Po Wang, Wen-Miao Chen, Xiao-Yu Li, Cyril Rajnák, Zhen-Yu Feng, Mohamedally Kurmoo, Roman Boča, Chunjiang Jia, Chen-Ho Tung, Di Sun
We report an unprecedented reversible dynamic transformation in a metal-organic framework involving bond formation that is accompanied by two important structural changes, achiral to chiral and two- to three-dimension. Using two bent organic lig-ands (diimpym = 4,6-di(1H-imidazol-1-yl)pyrimidine; H2npta = 5-nitroisophthalic acid) and CoII(NO3)2*6H2O the coordination pol-ymer Co(diimpym)(npta)*CH3OH, 1*CH3OH, was obtained sol-vothermally. Its structure consisting of knitted pairs of square layers (44-sql) of five-coordinated Co, disordered methanol and crystallizing in achiral Pbca space group at room temperature undergoes a single-crystal to single-crystal (SC-SC) transfor-mation to a 3D interpenetrated framework (pcu) of six-coordinated Co and ordered methanol in chiral P212121 space group below 220 K...
March 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28326238/fiber-optic-sensors-based-on-hybrid-phenyl-silica-xerogel-films-to-detect-n-hexane-determination-of-the-isosteric-enthalpy-of-adsorption
#15
Jesús C Echeverría, Ignacio Calleja, Paula Moriones, Julián J Garrido
We investigated the response of three fiber optic sensing elements prepared at pH 10 from phenyltriethoxysilane (PhTEOS) and tetraethylsilane (TEOS) mixtures with 30, 40, and 50% PhTEOS in the silicon precursor mixture. The sensing elements are referred to as Ph30, Ph40 and Ph50, respectively. The films were synthesized by the sol-gel method and affixed to the end of optical fibers by the dip-coating technique. Fourier transform infrared spectroscopy, N2 adsorption-desorption at 77 K and X-ray diffraction analysis were used to characterize the xerogels...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28325325/pei-cellulose-nanocrystal-hybrids-as-efficient-sirna-delivery-agents-synthesis-physicochemical-characterization-and-in-vitro-evaluation
#16
Gautier M A Ndong Ntoutoume, Vincent Grassot, Frédérique Brégier, Julien Chabanais, Jean-Michel Petit, Robert Granet, Vincent Sol
We describe the synthesis of cellulose nanocrystals (CNCs) complexed to siRNA. PEI (600Da) was first covalently attached to CNCs by reductive amination reaction, then CNCs-PEI were loaded with siRNA, resulting in the formation of CNCs-PEI-siRNA particles, strongly stabilized by ionic interactions. Efficient cellular uptake of these particles was monitored by ethidium bromide staining. Not only did CNCs-PEI show no cytotoxicity at the studied concentrations, but they also protected siRNA from degradation and favored its delivery into the cells...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28323563/isolation-of-an-h5n8-highly-pathogenic-avian-influenza-virus-strain-from-wild-birds-in-seoul-a-highly-urbanized-area-in-south-korea
#17
Jung-Hoon Kwon, Dong-Hun Lee, Jei-Hyun Jeong, Seong-Su Yuk, Tseren-Ochir Erdene-Ochir, Jin-Yong Noh, Woo-Tack Hong, Sol Jeong, Gyeong-Bin Gwon, Sang-Won Lee, In-Soo Choi, Chang-Seon Song
Asian-lineage H5 highly pathogenic avian influenza viruses (HPAIV) have caused recurrent outbreaks in poultry and wild birds. In January 2014, H5N8 HPAIV caused outbreaks in South Korea and subsequently spread to East Asia, Europe, and North America. We report the isolation of an H5N8 HPAIV strain from wild birds in Seoul, the most-developed city in South Korea. We analyzed the complete genome sequence of this isolate and estimated its origin using a phylogenetic analysis. The Seoul H5N8 isolate clustered phylogenetically with strains isolated from migratory wild birds but was distinct from Korean poultry isolates...
March 21, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28323456/stratosphere-conditions-inactivate-bacterial-endospores-from-a-mars-spacecraft-assembly-facility
#18
Christina L Khodadad, Gregory M Wong, Leandro M James, Prital J Thakrar, Michael A Lane, John A Catechis, David J Smith
Every spacecraft sent to Mars is allowed to land viable microbial bioburden, including hardy endospore-forming bacteria resistant to environmental extremes. Earth's stratosphere is severely cold, dry, irradiated, and oligotrophic; it can be used as a stand-in location for predicting how stowaway microbes might respond to the martian surface. We launched E-MIST, a high-altitude NASA balloon payload on 10 October 2015 carrying known quantities of viable Bacillus pumilus SAFR-032 (4.07 × 10(7) spores per sample), a radiation-tolerant strain collected from a spacecraft assembly facility...
March 21, 2017: Astrobiology
https://www.readbyqxmd.com/read/28323455/the-sleep-of-the-ring-comparison-of-the-%C3%A5-ura-sleep-tracker-against-polysomnography
#19
Massimiliano de Zambotti, Leonardo Rosas, Ian M Colrain, Fiona C Baker
OBJECTIVE/BACKGROUND: To evaluate the performance of a multisensor sleep-tracker (ŌURA ring) against polysomnography (PSG) in measuring sleep and sleep stages. PARTICIPANTS: Forty-one healthy adolescents and young adults (13 females; Age: 17.2 ± 2.4 years). METHODS: Sleep data were recorded using the ŌURA ring and standard PSG on a single laboratory overnight. Metrics were compared using Bland-Altman plots and epoch-by-epoch (EBE) analysis...
March 21, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28323381/dendrimer-reinforced-sol-gel-based-hollow-fiber-solid-phase-microextraction-for-citalopram-determination-using-response-surface-methodology
#20
Salameh Azimi, Zarrin Es'haghi, Ghasem Rezanejade Bardajee
The inclusion of a polyamidoamine dendrimer in a silica sol-gel yielded a solid nanosorbent that was used for the preconcentration, extraction and determination of citalopram in hospital waste water, hemodialysis solution and some drinking water. The method was developed by applying a novel nanosorbent for the solid-phase microextraction of citalopram, containing a silica sol-gel reinforced by polyamidoamine second-generation dendrimer, which was protected by a polypropylene hollow fiber. Plackett-Burman design and central composite design were utilized to evaluate the significance of several factors on the extraction efficiency...
March 21, 2017: Journal of Separation Science
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