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Zheng Wang, Dan Shao, Zhimin Chang, Mengmeng Lu, Yingshuai Wang, Juan Yue, Dian Yang, Mingqiang Li, Qiaobing Xu, Wenfei Dong
There is a pressing need to develop nanoplatforms that integrate multimodal therapeutics to improve treatment responses and prolong the survival of patients with unresectable hepatocellular carcinoma (HCC). Mesoporous silica-coated gold nanomaterials have emerged as a novel multifunctional platform combining tunable surface plasmon resonance and mesoporous properties that exhibit multimodality properties in cancer theranostics. However, their reduced radiation-absorption efficiency and limited surface area hinder their further radiochemotherapeutic applications...
November 15, 2017: ACS Nano
Shokufeh Aghabeygi, Mostafa Khademi-Shamami
ZnO/ZrO2 nanocomposites with different ZnO: ZrO2 molar ratios (2:1, 1:1, and 1:2)were prepared by sol gel approach under ultrasonic irradiation. For preparation of the nano-composites, the ZnO gel was directly incorporated into the ZrO2 gel at different molar ratios. The reaction mixture was stirred continuously for two days and then it was ultrasonoicated for 30min. The filtrated composite gel was washed, and then calcinated at 300°C in furnace for 3h. X-ray powder diffraction patterns exhibited well-formed crystal structures and pure crystalline phases in the synthesized nanoparticles (NPs)...
March 2018: Ultrasonics Sonochemistry
Shanxia Jin, Wei Zhang, Qin Yang, Lili Dai, Ping Zhou
In this work, inorganic boronate affinity monolith was prepared by in situ synthesis in 0.33mm i.d. stainless steel needle through sol-gel process using tetraethoxysilane and tetrabutyl orthotitanate as the co-precursors. The morphology, structure and composition of the monolith were characterized. In contrast to conventional boronate affinity materials, inorganic boric acid was used as affinity ligand. Different compounds were used for the evaluation of the boronate affinity of this inorganic monolithic material...
February 1, 2018: Talanta
Mohammad T Jafari, Mohammad R Rezayat, Mehdi Mossaddegh
An appropriate injection port was designed and constructed for direct analysis of stir-bar sorptive extractions using an ion mobility spectrometry (IMS). The novel design of the port offers great simplicity in use, high sensitivity, and high thermal and mechanical stability. The sol-gel technique was applied to prepare polydimethylsiloxane absorbent on a stir-bar. The parameters affecting extraction efficiency including stirring rate, extraction temperature, extraction time, salt addition and desorption temperature were optimized...
February 1, 2018: Talanta
Xinghui Liang, Xing Ou, Hong Dai, Fenghua Zheng, Qichang Pan, Peipei Liu, Xunhui Xiong, Meilin Liu, Chenghao Yang
Carbon-coated VPO4 nanoparticles embedded into a porous carbon matrix were synthesized via a facile sol-gel approach and investigated as a novel polyanion anode material for sodium-ion batteries. The VPO4@carbon anode demonstrates excellent rate capability and superior cyclic stability (245.3 mA h g(-1) at 1000 mA g(-1) after 200 cycles).
November 14, 2017: Chemical Communications: Chem Comm
Alfin Kurniawan, Chintya Effendi, Meng-Jiy Wang
The incorporation of inorganic materials into electrospun nanofibers has recently gained considerable attention for the development of ECM-like scaffolds with improved mechanical properties and enhanced biological functions for tissue engineering applications. In this study, polymer-inorganic composite fibers consisting of poly(2-ethyl-2-oxazoline) (PEOXA) and tetrabutyl titanate (TBT) as the titanium precursor were successfully fabricated through a combined sol-gel/electrospinning approach. PEOXA/Ti(OR)n composite fibers were obtained with varying amounts of polymer and titanium precursors...
November 14, 2017: Journal of Tissue Engineering and Regenerative Medicine
Diane M Sepa-Kishi, Yass Sotoudeh-Nia, Ayesha Iqbal, George Bikopoulos, Rolando B Ceddia
This study investigated fiber type-specific metabolic responses and the molecular mechanisms that regulate glucose and fat metabolism in oxidative and glycolytic muscles upon cold acclimation. Male Wistar rats were exposed to cold (4 °C) for 7 days, and then glycogen synthesis and content, glucose and palmitate oxidation, and the molecular mechanisms underlying these metabolic pathways were assessed in soleus (Sol), extensor digitorum longus (EDL), and epitrochlearis (Epit) muscles. Cold acclimation increased glycogen synthesis, glycogen content, glucose oxidation, and reduced glycogen synthase (GS) phosphorylation only in Sol muscles...
November 13, 2017: Scientific Reports
Tianyang Ren, Qian Wang, Ying Xu, Lin Cong, Jingxin Gou, Xiaoguang Tao, Yu Zhang, Haibing He, Tian Yin, Haotian Zhang, Yan Zhang, Xing Tang
Polymer-lipid hybrid nanoparticles, PMONPs, were developed to improve the oral absorption of cabazitaxel (CTX), a semi-synthetic taxane derivative, by overcoming multiple gastrointestinal barriers. The nano-carrier is comprised of a poly(ε-caprolactone) (PCL) and chain triglyceride (MCT) hybrid core for drug loading, and a positively charged surface while slightly concealed with a polyethylene oxide (PEO) shell by insertion of poloxamer 188, with the aim of improving the intestinal mucus permeation and epithelial cell uptake...
November 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
Soyoung Son, Vijayakameswara Rao, Hyewon Ko, Sol Shin, Jueun Jeon, Hwa Seung Han, Van Quy Nguyen, Thavasyappan Thambi, Yung Doug Suh, Jae Hyung Park
In an attempt to develop the hypoxia-responsive nanoparticles for cancer therapy, a polymer conjugate, consisting of carboxymethyl dextran (CMD) and black hole quencher 3 (BHQ3), was prepared. The polymer conjugate can self-assemble into nanoparticles (CMD-BHQ3 NPs) under aqueous conditions. The anticancer drug, doxorubicin (DOX), was loaded in CMD-BHQ3 NPs to prepare DOX@CMD-BHQ3 NPs. The CMD-BHQ3 NPs released DOX in a sustained manner under physiological conditions, whereas the release rate of DOX remarkably increased under hypoxic conditions throughout the cleavage of the azo bond in BHQ3...
November 10, 2017: International Journal of Biological Macromolecules
Michelle M Cerreta, Kevin J Johnson, Braden C Giordano
Typical trace vapor analysis involves sorbent trapping, followed by desorption and chromatographic separation. This communication describes a method for streamlining this process by combining sorbent sampling/preconcentration with partial separation achieved through temperature-programmed thermal desorption. A novel sorbent trap was formulated in which tubular glass liners for a programmable-temperature gas chromatograph inlet were coated with a sol-gel based polymer stationary phase synthesized from methyltrimethoxysilane precursor and installed into the inlet, which was directly connected to a mass-selective detector by a fused silica capillary transfer line...
November 4, 2017: Journal of Chromatography. A
Liping Zhang, Pramila Ghimire, Jenjira Phuriragpitikhon, Baojiang Jiang, Alexandre A S Gonçalves, Mietek Jaroniec
Bismuth/bismuth oxide heterojunction on porous carbon (Bi(0)/Bi2O3@C) was successfully prepared by a surfactant-assisted sol-gel method. This composite photocatalyst was fabricated by depositing Bi2O3 and metallic bismuth nanoparticles (NPs) on porous carbon sheets. Bi NPs were created by in-situ reduction of Bi2O3 with amorphous carbon. During the synthesis, bismuth and carbon precursors were mixed in different ratios, resulting in distinct amounts of metallic bismuth in the composites. The composites showed large specific surface area and pore volume as well as strong light absorption ability due to the existing carbon...
November 6, 2017: Journal of Colloid and Interface Science
M J López-Muňoz, A Daniele, M Zorzi, C Medana, P Calza
The photocatalytic transformation of acesulfame K - an artificial sweetener that has gained popularity over the last decades for being a calorie-free additive in food, beverages and several pharmaceutical products - was studied using three different photocatalysts, the benchmark TiO2-P25 and two other forms of synthetized titanium oxides named TiO2-SG1 and TiO2-SG2. The two latter materials were synthesized by a sol gel process in which the hydrolysis rate of titanium n-butoxide was controlled by the water formed in situ through an esterification reaction between ethanol and acetic acid...
November 4, 2017: Chemosphere
Wenjia Shen, Xiaobin Chen, Jiabin Luan, Danni Wang, Lin Yu, Jiandong Ding
The sustained release of both the hydrophilic drug and hydrophobic drug from one delivery system remains challenging in pharmaceutics and biomaterials science. The combination of hydrophilic cisplatin and hydrophobic paclitaxel (PTX) exhibits a clinical survival advantage compared with the individual drug therapy against various tumors such as ovarian cancer. In this study, a localized, long-term codelivery system of cisplatin and PTX was developed using an injectable and thermosensitive polymer-platinum(IV) conjugate hydrogel as the carrier...
November 13, 2017: ACS Applied Materials & Interfaces
Sung-Ho Shin, Seong-Young Choi, Min Hyung Lee, Junghyo Nah
We report high performance piezoelectric nanogenerators (PENGs) with nanoimprinted sol-gel BaTiO3 (BTO) nanopillar array polarized under high electric field and ultraviolet. The PENGs fabricated using this method demonstrate greatly enhanced output voltage of ~10 V and current density of ~1.2 μA cm-2, respectively, in comparison to that of flat PENG. Further, the PENG demonstrates uniform output characteristics over the entire device area thanks to uniform nanoimprint pillar array. The approach introduced here is simple, effective, reliable, and reproducible way to fabricate high performance sol-gel based PENGs and electronic devices...
November 13, 2017: ACS Applied Materials & Interfaces
Virginie Hugouvieux, Walter Kob
We use computer simulations to investigate how a catalytic reaction in a polymer sol can induce the formation of a polymer gel. To this aim we consider a solution of homopolymers in which freely-diffusing catalysts convert the originally repulsive A monomers into attractive B ones. We find that at low temperatures this reaction transforms the polymer solution into a physical gel that has a remarkably regular mesostructure in the form of a cluster phase, absent in the usual homopolymer gels obtained by a quench in temperature...
November 13, 2017: Soft Matter
Parichart Naruphontjirakul, Alexandra E Porter, Julian R Jones
Monodispersed strontium containing bioactive glass nanoparticles (Sr-BGNPs) with two compositions were synthesised, through a modified sol-gel Stöber process, wherein silica nanoparticles (SiO2-NPs) were formed prior to incorporation of calcium and strontium, with diameters of 90 ± 10 nm. The osteogenic response of a murine preosteoblast cell line, MC3T3-E1, was investigated in vitro for a nanoparticle concentration of 250 µg/mL with compositions of 87 mol% SiO2, 7 mol% CaO, 6 mol% SrO and 83 mol% SiO2, 3 mol% CaO, 14 mol% SrO...
November 9, 2017: Acta Biomaterialia
Ignasi Sols, Sarah DuBrow, Lila Davachi, Lluís Fuentemilla
Although everyday experiences unfold continuously over time, shifts in context, or event boundaries, can influence how those events come to be represented in memory [1-4]. Specifically, mnemonic binding across sequential representations is more challenging at context shifts, such that successful temporal associations are more likely to be formed within than across contexts [1, 2, 5-9]. However, in order to preserve a subjective sense of continuity, it is important that the memory system bridge temporally adjacent events, even if they occur in seemingly distinct contexts...
November 4, 2017: Current Biology: CB
Longqing Mi, Yongyi Feng, Lei Cao, Mingqiang Xue, Yanlin Huang, Lin Qin, Hyo Jin Seo
Silver-containing lanthanum metaniobate Ag0.5La0.5Nb2O6 nanoparticles were synthesized by sol-gel polymerized complex method. A typical defect-perovskite structure was confirmed by XRD Rietveld refinements. The surface characteristics of the sample were tested by SEM, TEM and EDS measurements. SEM and TEM show that the sample presents ball-like particles with the diameters of 100nm to 400nm. The sample shows both self-activated luminescence and photocatalytic activities. Ag0.5La0.5Nb2O6 has a direct transition with band energy of 2...
November 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Selim Demirci, Metin Yurddaskal, Tuncay Dikici, Cevat Sarıoğlu
In this work, iodine (I) doped hollow and mesoporous Fe2O3 photocatalyst particles were fabricated for the first time through sol-gel method. Phase structure, surface morphology, particle size, specific surface area and optical band gap of the synthesized Fe2O3 photocatalysts were analyzed by X-ray diffraction (XRD), field emission scanning electron microscope (FESEM), X-ray photoelectron spectroscopy (XPS), BET surface analysis, particle size analyzer and UV-vis diffuse reflectance spectrum (UV-vis DRS), respectively...
November 7, 2017: Journal of Hazardous Materials
Martin Zaback, Brian C Horslen, Taylor W Cleworth, Laurel Collins, Cécile Langlet, J Timothy Inglis, Mark G Carpenter
Previous research has shown that cutaneous reflexes are modulated when walking with a threat to stability. It is unclear if this reflex modulation is purely related to the context of the imposed threat or if emotional changes associated with the threat exert an independent influence on reflex excitability. This study investigated the influence of emotional stimuli on lower limb cutaneous reflexes during treadmill walking. Twenty-eight healthy young adults walked at a self-selected pace while viewing pictures that manipulated emotional arousal and valence (confirmed with electrodermal and self-report measures)...
November 8, 2017: Neuroscience Letters
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