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glucose and Dopamine

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https://www.readbyqxmd.com/read/28732957/sonochemical-synthesis-of-silver-nanoparticles-anchored-reduced-graphene-oxide-nanosheets-for-selective-and-sensitive-detection-of-glutathione
#1
Victor Vinoth, Jerry J Wu, Abdullah M Asiri, Sambandam Anandan
Developed here an eco-friendly, one-pot approach toward rapid synthesis of silver nanoparticles anchored reduced graphene oxide (AgNPs(TMSPED)-rGO) nanosheets via sonochemical irradiation method, using an aqueous solution mixture of GO and AgNO3 in the presence of N-[3(trimethoxysilyl)propyl] ethylenediamine (TMSPED) without any reducing agent. As synthesized decorated nanosheets was thoroughly characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) spectroscopy, Raman spectroscopy and X-ray photoelectron spectroscopy (XPS)...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28693727/one-step-synthesis-of-functional-pnr-rgo-composite-as-a-building-block-for-enhanced-ascorbic-acid-biosensing
#2
Ling Liu, Junfeng Zhai, Chengzhou Zhu, Lei Han, Wen Ren, Shaojun Dong
An electrochemical sensor for ascorbic acid (AA) was prepared via an one-step electrochemical approach by reducing graphene oxide (rGO) and co-polymerizing neutral red (NR) and rGO to form a pNR/rGO hybrid film on the glassy carbon electrode (pNR/rGO-GCE). Structures and properties of the obtained pNR/rGO film were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FT-IR) and UV-vis techniques. A significant decrease of charge-transfer resistance (Rct) from over 20,000 Ω for pNR-GCE to 130 Ω for pNR/rGO-GCE was validated by electrochemical impedance spectroscopy (EIS) measurement...
August 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28681931/assessments-of-plasma-ghrelin-levels-in-the-early-stages-of-parkinson-s-disease
#3
Ning Song, Weiwei Wang, Fengjv Jia, Xixun Du, Anmu Xie, Qing He, Xiaoli Shen, Jing Zhang, Jack T Rogers, Junxia Xie, Hong Jiang
BACKGROUND: Gastrointestinal symptoms are early events in Parkinson's disease (PD). The gastrointestinal hormone ghrelin was neuroprotective in the nigrostriatal dopamine system. The objective of this study was to assess ghrelin levels in the early stages of PD. METHODS: Plasma was collected in the fasting state in 291 PD patients in stages 1-3 and 303 age- and sex-matched healthy controls. Additional samples were taken in the glucose response test to assess nutrition-related ghrelin levels in 20 PD patients and 20 healthy controls...
July 6, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28666800/a-novel-glp-1-gip-dual-agonist-is-more-effective-than-liraglutide-in-reducing-inflammation-and-enhancing-gdnf-release-in-the-mptp-mouse-model-of-parkinson-s-disease
#4
Ziyue Yuan, Dongfang Li, Peng Feng, Guofang Xue, Chenhui Ji, Guanglai Li, Christian Hölscher
Type 2 diabetes mellitus (T2DM) is one of the risk factors for Parkinson's disease (PD). Insulin desensitisation has been observed in the brains of patients, which may promote neurodegeneration. Incretins are a family of growth factors that can re-sensitise insulin signalling. We have previously shown that mimetics of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have neuroprotective effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine (MPTP) mouse model of PD...
June 27, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28656770/mimicking-peroxidase-activities-with-prussian-blue-nanoparticles-and-their-cyanometalate-structural-analogues
#5
Margarita Vázquez-González, Rebeca M Torrente-Rodríguez, Anna Kozell, Wei-Ching Liao, Alessandro Cecconello, Susana Campuzano, José M Pingarrón, Itamar Willner
Nanoparticles composed of Prussian Blue, PB, and the cyanometalate structural analogues, CuFe, FeCoFe, and FeCo, are examined as inorganic clusters that mimic the functions of peroxidases. PB acts as a superior catalyst for the oxidation of dopamine to aminochrome by H2O2. The oxidation of dopamine by H2O2 in the presence of PB is 6-fold faster than in the presence of CuFe. The cluster FeCo does not catalyze the oxidation of dopamine to aminochrome. The most efficient catalyst for the generation of chemiluminescence by the oxidation of luminol by H2O2 is, however, FeCo, and PB lacks any catalytic activity toward the generation of chemiluminescence...
July 10, 2017: Nano Letters
https://www.readbyqxmd.com/read/28654068/fabrication-of-3d-carbon-microelectromechanical-systems-c-mems
#6
Bidhan Pramanick, Sergio O Martinez-Chapa, Marc Madou, Hyundoo Hwang
A wide range of carbon sources are available in nature, with a variety of micro-/nanostructure configurations. Here, a novel technique to fabricate long and hollow glassy carbon microfibers derived from human hairs is introduced. The long and hollow carbon structures were made by the pyrolysis of human hair at 900 °C in a N2 atmosphere. The morphology and chemical composition of natural and pyrolyzed human hairs were investigated using scanning electron microscopy (SEM) and electron-dispersive X-ray spectroscopy (EDX), respectively, to estimate the physical and chemical changes due to pyrolysis...
June 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28636436/signal-on-fluorescent-sensor-based-on-n-cqds-for-the-detection-of-glutathione-in-human-serum-and-pharmaceutic-preparation
#7
Chengfei Zhao, Kangying Wang, Qihong Cai, Haijian Tu, Linghong Pan, Liumin Yu
Nitrogen-doped carbon quantum dots (N-CQDs) with citric acid and ethylenediamine as raw materials were synthesized by an efficient one-step strategy. The N-CQDs showed a special property that the fluorescence was quenched by Fe(3+). The quenched fluorescence of N-CQDs could be recovered by glutathione (GSH). Therefore, a "signal-on" fluorescent sensor was developed to detect GSH. The fluorescent sensor could favorably avoid the interference of ascorbic acid, dopamine, glucose, oxidized glutathione and other amino acids in the detecting process of GSH...
June 21, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28621523/mussel-inspired-hyaluronic-acid-derivative-nanostructures-for-improved-tumor-targeting-and-penetration
#8
Song Yi Lee, Ju-Hwan Park, Seung-Hak Ko, Jae-Seong Shim, Dae-Duk Kim, Hyun-Jong Cho
An amphiphilic hyaluronic acid-ceramide-dopamine (HACE-d) conjugate was prepared, and HACE-d-based nanoparticles (NPs) including phloretin (as an inhibitor of glucose transporter (GLUT1)) were fabricated. Mussel-inspired property of d was introduced to HACE NPs, and it may improve tumor targetability and penetration in addition to passive (based on enhanced permeability and retention effect) and active (interaction between HA and CD44 receptor) tumor targeting effects. HACE-d/phloretin NPs with 279 nm mean diameter, ∼0...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28595536/neuroprotective-effects-of-drug-induced-therapeutic-hypothermia-in-central-nervous-system-diseases
#9
Junwei Ma, Yibin Wang, Zhong Wang, Haiying Li, Zhimin Wang, Gang Chen
Cerebrovascular diseases often cause neurological deficits. Experimental studies have shown that drug-induced hypothermia alleviates brain damage and plays a neuroprotective role, thereby reducing mortality and ameliorating neurological deficits. Therefore, drug-induced hypothermia has an important research value and is further considered in the clinical setting. However, drug-induced hypothermia is also associated with side effects, such as ventricular tachycardia, ventricular fibrillation, suppressed immune function, infection, electrolyte imbalance, glucose metabolism disorders, and skeletal muscle tremor...
June 6, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28588361/caffeine-and-cannabis-effects-on-vital-neurotransmitters-and-enzymes-in-the-brain-tissue-of-juvenile-experimental-rats
#10
J O Owolabi, S Y Olatunji, A J Olanrewaju
BACKGROUND: Caffeine and cannabis are globally consumed and abused psychoactive substances. While caffeine is legally used in various forms, including in tea and coffee as beverages, it is also consumed in soda and energy drinks as additives. Cannabis, on the other hand, is considered illegal in most countries; albeit, it is being consumed globally particularly by adolescents. PURPOSE: The adolescent stage marks a critical stage of brain development and maturation...
May 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28580946/dopamine-d2-receptor-signaling-in-the-nucleus-accumbens-comprises-a-metabolic-cognitive-brain-interface-regulating-metabolic-components-of-glucose-reinforcement
#11
Michael Michaelides, Michael L Miller, Jennifer A DiNieri, Juan L Gomez, Elizabeth Schwartz, Gabor Egervari, Gene Jack Wang, Charles V Mobbs, Nora D Volkow, Yasmin L Hurd
Appetitive drive is influenced by coordinated interactions between brain circuits that regulate reinforcement and homeostatic signals that control metabolism. Glucose modulates striatal dopamine (DA), and regulates appetitive drive and reinforcement learning. Striatal DA D2 receptors (D2R) also regulate reinforcement learning, and are implicated in glucose-related metabolic disorders. Nevertheless, interactions between striatal D2R and peripheral glucose have not been previously described. Here we show that manipulations involving striatal D2R signaling coincide with perseverative and impulsive-like responding for sucrose, a disaccharide consisting of fructose and glucose...
June 5, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28575963/highly-sensitive-and-selective-non-enzymatic-electrochemical-glucose-sensors-based-on-graphene-oxide-molecular-imprinted-polymer
#12
Sheeba Alexander, P Baraneedharan, Shriya Balasubrahmanyan, S Ramaprabhu
Graphene Oxide-Molecular Imprinted Polymer (GO-MIP) based electrochemical sensor was developed for the first time towards enzyme less determination of glucose. This GO-MIP was obtained from a series of fictionalization, polymerization and template molecule introduction/removal during the synthesizing process. The proposed GO-MIP based electrode showed excellent electrocatalytic activity towards glucose oxidation at optimized conditions and possessing detection limit of 0.1nM with a response time of ~2min. The current response of GO-MIP based glucose sensor was linearly related to the concentration of glucose...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28560263/dopamine-d2-receptors-and-the-circadian-clock-reciprocally-mediate-antipsychotic-drug-induced-metabolic-disturbances
#13
Zachary Freyberg, Michael J McCarthy
Antipsychotic drugs are widely prescribed medications, used for numerous psychiatric illnesses. However, antipsychotic drugs cause serious metabolic side effects that can lead to substantial weight gain and increased risk for type 2 diabetes. While individual drugs differ, all antipsychotic drugs may cause these important side effects to varying degrees. Given that the single unifying property shared by these medications is blockade of dopamine D2 and D3 receptors, these receptors likely play a role in antipsychotic drug-induced metabolic side effects...
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28539708/assessment-of-mexican-arnica-heterotheca-inuloides-cass-and-rosemary-rosmarinus-officinalis-extracts-on-dopamine-and-selected-biomarkers-of-oxidative-stress-in-stomach-and-brain-of-salmonella-typhimurium-infected-rats
#14
David Calderón Guzmàn, Maribel Ortiz Herrera, Norma Osnaya Brizuela, Gerardo Barragàn Mejía, Ernestina Hernàndez García, Hugo Juàrez Olguín, Armando Valenzuela Peraza, Norma Labra Ruíz, Daniel Santamaría Del Angel
BACKGROUND: The effects of some natural products on dopamine (DA) and 5-hydroxyindole acetic acid (5-HIAA) in brain of infected models are still unclear. OBJECTIVE: The purpose of this study was to measure the effect of Mexican arnica/rosemary (MAR) water extract and oseltamivir on both biogenic amines and some oxidative biomarkers in the brain and stomach of young rats under infection condition. METHODS: Female Wistar rats (weight 80 g) in the presence of MAR or absence (no-MAR) were treated as follows: group 1, buffer solution (controls); oseltamivir (100 mg/kg), group 2; culture of Salmonella typhimurium (S...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28516289/understanding-the-stability-of-dopamine-and-dobutamine-over-24%C3%A2-h-in-simulated-neonatal-ward-conditions
#15
Katherine Kirupakaran, Liam Mahoney, Heike Rabe, Bhavik A Patel
OBJECTIVES: Our objectives were to investigate the possible effects of temperature and light on the stability of dopamine and dobutamine continuous infusions over 24 h when prepared in a variety of dilution vehicles. METHODS: Syringe-driver infusion apparatuses were set up for dopamine and dobutamine diluted with either 0.9% sodium chloride (NaCl) or 5% glucose delivering 3 and 5 μg/kg/min, respectively, via 206-cm extension sets. All infusions were prepared for a neonate weight of 1 kg...
May 17, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28485313/clinical-characteristics-and-current-interventions-in-shock-patients-in-chinese-emergency-departments-a-multicenter-prospective-cohort-study
#16
Shu-Bin Guo, Yun-Xia Chen, Xue-Zhong Yu
BACKGROUND: Shock is a life-threatening condition in emergency departments (EDs) and is associated with a high mortality; however, its clinical characteristics and current interventions in China are seldom reported. This study investigated the clinical characteristics and current interventions of shock patients in Chinese EDs. METHODS: This multicenter prospective cohort study was conducted in the EDs of 33 academic hospitals in 16 Chinese provinces. Adult shock patients were enrolled from December 2013 to April 2014...
May 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28437058/psychotic-and-bipolar-disorders-antipsychotic-drugs
#17
REVIEW
Sarah D Holder, Alaina L Edmunds, Sherri Morgan
Antipsychotic drugs block dopamine receptors and are used to manage psychosis as well as other mental illnesses that may or may not have psychotic features, such as bipolar disorders and major depressive disorder. First-generation antipsychotic drugs are more likely to cause adverse effects such as extrapyramidal symptoms and tardive dyskinesia. Adverse effects of second-generation antipsychotic drugs typically are related to metabolic abnormalities such as weight gain, abnormal blood glucose levels, and elevated lipid levels...
April 2017: FP Essentials
https://www.readbyqxmd.com/read/28433974/hypoactive-hypoalert-behaviour-and-thalamic-hypometabolism-due-to-intracranial-hypotension
#18
Seamus Kearney, Peter Flynn, Simon Hughes, Wendy Spence, Mark Owen McCarron
A 47-year-old man presented with a 9-year history of a hypoalert hypoactive behaviour syndrome, caused by the deep brain swelling variant of spontaneous intracranial hypotension. Along with apathy with retained cognition, he had stable ataxia, impaired upgaze and episodes of central apnoea. MRI brain showed a sagging brainstem, pointed ventricles and reduced angle between the vein of Galen and the straight sinus, but no meningeal enhancement or subdural collections. A dopamine transporter scan showed preganglionic dopamine receptor deficiency; a fluorodeoxy glucose positron emission tomography scan showed bilateral hypothalamic hypometabolism...
August 2017: Practical Neurology
https://www.readbyqxmd.com/read/28433467/modeling-hypohedonia-following-repeated-social-defeat-individual-vulnerability-and-dopaminergic-involvement
#19
Samantha R Spierling, Maegan Mattock, Eric P Zorrilla
Social defeat in rodents putatively can model hypohedonia. The present studies examined models for assessing hypohedonia-like behavior and tested the hypotheses that 1) individual differences in baseline reward sensitivity predict vulnerability, and 2) defeat elicits changes in pharmacological measures of striatal dopaminergic function. Male Wistar rats (n=142) received repeated defeat (3 "triad" blocks of 3 defeats) or control handling. To determine whether defeat influenced consumption of SuperSac (glucose-saccharin) over an isocaloric, less preferred, glucose solution, a 2-choice paradigm was used...
August 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28420085/electrochemical-detection-of-dopamine-using-3d-porous-graphene-oxide-gold-nanoparticle-composites
#20
Sung-Sik Choo, Ee-Seul Kang, Inbeom Song, Donghyun Lee, Jeong-Woo Choi, Tae-Hyung Kim
The detection of dopamine in a highly sensitive and selective manner is crucial for the early diagnosis of a number of neurological diseases/disorders. Here, a report on a new platform for the electrochemical detection of dopamine with a considerable accuracy that comprises a 3D porous graphene oxide (pGO)/gold nanoparticle (GNP)/pGO composite-modified indium tin oxide (ITO) is presented. The pGO was first synthesized and purified by ultrasonication and centrifugation, and it was then further functionalized on the surface of a GNP-immobilized ITO electrode...
April 14, 2017: Sensors
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