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https://www.readbyqxmd.com/read/28214552/interocular-suppression-in-children-with-deprivation-amblyopia
#1
Lisa Hamm, Zidong Chen, Jinrong Li, Joanna Black, Shuan Dai, Junpeng Yuan, Minbin Yu, Benjamin Thompson
In patients with anisometropic or strabismic amblyopia, interocular suppression can be minimized by presenting high contrast stimulus elements to the amblyopic eye and lower contrast elements to the fellow eye. This suggests a structurally intact binocular visual system that is functionally suppressed. We investigated whether suppression can also be overcome by contrast balancing in children with deprivation amblyopia due to childhood cataracts. To quantify interocular contrast balance, contrast interference thresholds were measured using an established dichoptic global motion technique for 21 children with deprivation amblyopia, 14 with anisometropic or mixed strabismic/anisometropic amblyopia and 10 visually normal children (mean age mean = 9...
February 15, 2017: Vision Research
https://www.readbyqxmd.com/read/28188939/survey-of-nerve-fiber-layer-thickness-in-anisometropic-and-strabismic-amblyopia
#2
Reza Soltani Moghaddam, Abdolreza Medghalchi, Yousef Alizadeh
. To investigate the effect of anisometropic and strabismic amblyopia on the nerve fiber layer thickness. This cross-sectional study was done on 54 amblyopic subjects, equally in both strabismic and anisometropic groups. The thickness otonerve fiber layer measured in superior, inferior, nasal, temporal quadrants and as a whole in both eyes of both groups. The means of thickness were compared in amblyopic and sound eyes. In strabismus group, the average nerve fiber layer thickness of the sound eye , in superior, inferior, nasal and temporal quadrants and as a whole were 113...
January 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28166317/effects-of-reduced-acuity-and-stereo-acuity-on-saccades-and-reaching-movements-in-adults-with-amblyopia-and-strabismus
#3
Ewa Niechwiej-Szwedo, Herbert C Goltz, Linda Colpa, Manokaraananthan Chandrakumar, Agnes M F Wong
Purpose: Our previous work has shown that amblyopia disrupts the planning and execution of visually-guided saccadic and reaching movements. We investigated the association between the clinical features of amblyopia and aspects of visuomotor behavior that are disrupted by amblyopia. Methods: A total of 55 adults with amblyopia (22 anisometropic, 18 strabismic, 15 mixed mechanism), 14 adults with strabismus without amblyopia, and 22 visually-normal control participants completed a visuomotor task while their eye and hand movements were recorded...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28031397/electrical-stimulation-of-superior-colliculus-affects-strabismus-angle-in-monkey-models-for-strabismus
#4
Suraj Upadhyaya, Hui Meng, Vallabh E Das
Disruption of binocular vision during the critical period for development leads to eye misalignment in humans and in monkey models. We have previously suggested that disruption within a vergence circuit could be the neural basis for strabismus. Electrical stimulation in the rostral superior colliculus (rSC) leads to vergence eye movements in normal monkeys. Therefore the purpose of this study was to investigate the effect of SC stimulation on eye misalignment in strabismic monkeys. Electrical stimulation was delivered to 51 sites in the intermediate and deep layers of the SC (400Hz, 0...
December 28, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27982206/dysfunction-in-the-fellow-eyes-of-strabismic-and-anisometropic-amblyopic-children-assessed-by-visually-evoked-potentials
#5
Eric Pinheiro Andrade, Adriana Berezovsky, Paula Yuri Sacai, Josenilson Martins Pereira, Daniel Martins Rocha, Solange Rios Salomão
Purpose: To evaluate visual acuity and transient pattern reversal (PR) visual evoked potentials (VEPs) in the fellow eyes of children with strabismic and/or anisometropic amblyopia. Methods: Children diagnosed with strabismic and/or anisometropic amblyopia were recruited for electrophysiological assessment by VEPs. Monocular grating and optotype acuity were measured using sweep-VEPs and an Early Treatment Diabetic Retinopathy Study chart, respectively. During the same visit, transient PR-VEPs of each eye were recorded using stimuli subtending with a visual angle of 60', 15', and 7...
September 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27960584/the-prevalence-of-strabismus-and-associated-risk-factors-in-a-southeastern-region-of-brazil
#6
Luisa Fioravanti Schaal, Silvana Artioli Schellini, Leonardo Toledo Pesci, Alicia Galindo, Carlos Roberto Padovani, Jose Eduardo Corrente
PURPOSE: To determine the prevalence of strabismus and associated risk factors in southeastern Brazil. METHODS: A cross-sectional, population-based study using a systematic sample from nine municipalities in a southeastern region of Brazil composed of 1852 individuals aged ≥1 and ≤12 years old was done. Visual acuity (VA), ocular alignment, and refractive error (RE) were evaluated. Strabismic individuals (strabismus group) were compared to orthotropic individuals (orthotropic group) to analyze risk factors linked to heterotropias...
December 14, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27929726/treatment-of-amblyopia-using-personalized-dosing-strategies-statistical-modelling-and-clinical-implementation
#7
Michael P Wallace, Catherine E Stewart, Merrick J Moseley, David A Stephens, Alistair R Fielder
PURPOSE: To generate a statistical model for personalizing a patient's occlusion therapy regimen. METHODS: Statistical modelling was undertaken on a combined data set of the Monitored Occlusion Treatment of Amblyopia Study (MOTAS) and the Randomized Occlusion Treatment of Amblyopia Study (ROTAS). This exercise permits the calculation of future patients' total effective dose (TED)-that predicted to achieve their best attainable visual acuity. Daily patching regimens (hours/day) can be calculated from the TED...
December 2016: Strabismus
https://www.readbyqxmd.com/read/27895515/excellent-response-of-infantile-orbital-hemangioma-to-propranolol
#8
Fandresena A Sendrasoa, Irina M Ranaivo, Naina H Razanakoto, Malalaniaina Andrianarison, Lala S Ramarozatovo, F Rapelanoro Rabenja
Infantile hemangiomas are the most common vascular neoplasm that present in infancy, with more than half affecting the head and neck region. Periocularly, hemangiomas may be complicated by visual loss through induction of strabismal, deprivational, or anisometropic astigmatism. We report a case of a 5-year-old girl who presented with orbital hemangioma with potential risk of visual loss who had excellent response to propranolol.
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27859646/prevalence-of-non-strabismic-anomalies-of-binocular-vision-in-tamil-nadu-report-2-of-band-study
#9
Jameel Rizwana Hussaindeen, Archayeeta Rakshit, Neeraj Kumar Singh, Ronnie George, Meenakshi Swaminathan, Suman Kapur, Mitchell Scheiman, Krishna Kumar Ramani
BACKGROUND: Population-based studies on the prevalence of non-strabismic anomalies of binocular vision in ethnic Indians are more than two decades old. Based on indigenous normative data, the BAND (Binocular Vision Anomalies and Normative Data) study aims to report the prevalence of non-strabismic anomalies of binocular vision among school children in rural and urban Tamil Nadu. METHODS: This population-based, cross-sectional study was designed to estimate the prevalence of non-strabismic anomalies of binocular vision in the rural and urban population of Tamil Nadu...
November 18, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27820875/improvement-of-eye-alignment-in-adult-strabismic-monkeys-by-sustained-igf-1-treatment
#10
Linda K McLoon, Stephen P Christiansen, Geoffrey M Ghose, Vallabh E Das, Michael J Mustari
Purpose: The goal of this study was to determine if continuous application of insulin-like growth factor-1 (IGF-1) could improve eye alignment of adult strabismic nonhuman primates and to assess possible mechanisms of effect. Methods: A continuous release pellet of IGF-1 was placed on one medial rectus muscle in two adult nonhuman primates (M1, M2) rendered exotropic by the alternating monocular occlusion method during the first months of life. Eye alignment and eye movements were recorded for 3 months, after which M1 was euthanized, and the lateral and medial rectus muscles were removed for morphometric analysis of fiber size, nerve, and neuromuscular density...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27812703/effect-of-a-binocular-ipad-game-vs-part-time-patching-in-children-aged-5-to-12-years-with-amblyopia-a-randomized-clinical-trial
#11
Jonathan M Holmes, Vivian M Manh, Elizabeth L Lazar, Roy W Beck, Eileen E Birch, Raymond T Kraker, Eric R Crouch, S Ayse Erzurum, Nausheen Khuddus, Allison I Summers, David K Wallace
Importance: A binocular approach to treating anisometropic and strabismic amblyopia has recently been advocated. Initial studies have yielded promising results, suggesting that a larger randomized clinical trial is warranted. Objective: To compare visual acuity (VA) improvement in children with amblyopia treated with a binocular iPad game vs part-time patching. Design, Setting, and Participants: A multicenter, noninferiority randomized clinical trial was conducted in community and institutional practices from September 16, 2014, to August 28, 2015...
December 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27768799/altered-protein-composition-and-gene-expression-in-strabismic-human-extraocular-muscles-and-tendons
#12
Andrea B Agarwal, Cheng-Yuan Feng, Amy L Altick, David R Quilici, Dan Wen, L Alan Johnson, Christopher S von Bartheld
Purpose: To determine whether structural protein composition and expression of key regulatory genes are altered in strabismic human extraocular muscles. Methods: Samples from strabismic horizontal extraocular muscles were obtained during strabismus surgery and compared with normal muscles from organ donors. We used proteomics, standard and customized PCR arrays, and microarrays to identify changes in major structural proteins and changes in gene expression. We focused on muscle and connective tissue and its control by enzymes, growth factors, and cytokines...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27759855/choroidal-changes-in-anisometropic-and-strabismic-children-with-unilateral-amblyopia
#13
Christiane Al-Haddad, Maamoun Abdul Fattah, Karine Ismail, Ziad Bashshur
BACKGROUND AND OBJECTIVE: To detect changes in the choroidal layer at the macular area in amblyopic eyes. PATIENTS AND METHODS: A cross-sectional study of 50 amblyopic patients (20 strabismic and 30 anisometropic) and 50 controls was done. Cross-sectional images using enhanced depth optical coherence tomography (OCT) were taken. Thicknesses were measured subfoveally and at 1,500 µm nasally, temporally, inferiorly, and superiorly. Submacular corresponding choroidal areas were also computed...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27756405/binocular-treatment-of-amblyopia-using-videogames-bravo-study-protocol-for-a-randomised-controlled-trial
#14
Cindy X Guo, Raiju J Babu, Joanna M Black, William R Bobier, Carly S Y Lam, Shuan Dai, Tina Y Gao, Robert F Hess, Michelle Jenkins, Yannan Jiang, Lionel Kowal, Varsha Parag, Jayshree South, Sandra Elfride Staffieri, Natalie Walker, Angela Wadham, Benjamin Thompson
BACKGROUND: Amblyopia is a common neurodevelopmental disorder of vision that is characterised by visual impairment in one eye and compromised binocular visual function. Existing evidence-based treatments for children include patching the nonamblyopic eye to encourage use of the amblyopic eye. Currently there are no widely accepted treatments available for adults with amblyopia. The aim of this trial is to assess the efficacy of a new binocular, videogame-based treatment for amblyopia in older children and adults...
October 18, 2016: Trials
https://www.readbyqxmd.com/read/27737444/association-between-adherence-to-glasses-wearing-during-amblyopia-treatment-and-improvement-in-visual-acuity
#15
Gail D E Maconachie, Shegufta Farooq, Glen Bush, Julie Kempton, Frank A Proudlock, Irene Gottlob
Importance: Occlusion dose monitors have helped establish that better adherence to occlusion is associated with improved visual outcomes in patients undergoing amblyopia treatment. However, the role of adherence to glasses wearing is unknown. Objectives: To establish the feasibility and reliability of objectively monitoring adherence to glasses wearing using age-based norms, establish the association between adherence to glasses wearing and improvement in visual acuity (VA) after optical treatment and occlusion therapy, and analyze the effect of age, sex, refractive errors, type of amblyopia, and adherence to glasses wearing on improvement in VA...
December 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27699409/is-suppression-just-normal-dichoptic-masking-suprathreshold-considerations
#16
Alexandre Reynaud, Robert F Hess
Purpose: Amblyopic patients have a deficit in visual acuity and contrast sensitivity in their amblyopic eye as well as suppression of the amblyopic eye input under binocular viewing conditions. In this study we wanted to assess the origin of the amblyopic suppression by studying the contrast perception of the amblyopic eye at suprathreshold levels under binocular and monocular viewing. Methods: Using a suprathreshold contrast matching task in which the reference and target stimuli were presented to different eyes either simultaneously or successively, we measured interocular contrast matching in 10 controls and 11 amblyopes (mean age 35 ± 15; 5 strabismics; 3 anisometropes; 3 mixed)...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27621790/congenital-cataract-screening
#17
Zhale Rajavi, Hamideh Sabbaghi
Congenital cataract is a leading cause of visual deprivation which can damage the developing visual system of a child; therefore early diagnosis, management and long-term follow-up are essential. It is recommended that all neonates be screened by red reflex examination at birth and suspected cases be referred to ophthalmic centers. Early surgery (<6 weeks of age, based on general neonatal health) is important for achieving the best visual outcome particularly in unilateral cases. In bilateral cases, surgery is highly recommended before appearance of strabismus or nystagmus (<10 weeks of age) with no longer than a one-week interval between the fellow eyes...
July 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27607417/fine-motor-skills-of-children-with-amblyopia-improve-following-binocular-treatment
#18
Ann L Webber, Joanne M Wood, Benjamin Thompson
PURPOSE: The purpose of this study was to determine whether reduced fine motor skills in children with amblyopia improve after binocular treatment and whether improvements are sustained once treatment has ceased. METHODS: Fine motor skills (FMS [Bruininks-Oseretsky Test of Motor Proficiency]), visual acuity (VA [Early Treatment of Diabetic Retinopathy Study chart]) and level of binocular function (BF [Randot preschool stereoacuity and Worth 4 Dot]) were measured in children with amblyopia (n = 20; age: 8...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27605534/normal-correspondence-of-tectal-maps-for-saccadic-eye-movements-in-strabismus
#19
John R Economides, Daniel L Adams, Jonathan C Horton
The superior colliculus is a major brain stem structure for the production of saccadic eye movements. Electrical stimulation at any given point in the motor map generates saccades of defined amplitude and direction. It is unknown how this saccade map is affected by strabismus. Three macaques were raised with exotropia, an outwards ocular deviation, by detaching the medial rectus tendon in each eye at age 1 mo. The animals were able to make saccades to targets with either eye and appeared to alternate fixation freely...
December 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27580040/interocular-suppression-patterns-in-binocularly-abnormal-observers-using-luminance-and-contrast-modulated-noise-stimuli
#20
Akash S Chima, Monika A Formankiewicz, Sarah J Waugh
In binocular viewing, images presented to the amblyopic eye are suppressed in the cortex to prevent confusion or diplopia. The present study measures depth and extent of interocular suppression across the central circular 24° visual field in observers with strabismus and microstrabismus. Visual stimuli were concentric rings of alternating polarity, each divided into sectors. Rings were defined by luminance (L), luminance-modulated noise (LM), or contrast-modulated noise (CM). They were viewed binocularly except for the tested ring, which was viewed dichoptically, so that the modulation of one sector presented to the weaker or amblyopic eye was adjusted to perceptually match the surrounding ring presented to the preferred eye...
August 1, 2016: Journal of Vision
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