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https://www.readbyqxmd.com/read/28925604/epidemiology-and-prognosis-of-congenital-diaphragmatic-hernia-a-population-based-cohort-study-in-utah
#1
Hari Shanmugam, Luca Brunelli, Lorenzo D Botto, Sergey Krikov, Marcia L Feldkamp
BACKGROUND: Congenital diaphragmatic hernia (CDH) is a relatively frequent and severe malformation. Population-based data on clinical presentation and associated mortality are scarce. We examined a state-wide cohort of infants with a clinically validated diagnosis of CDH to assess their clinical profile, sociodemographic patterns, and infant mortality. METHODS: We identified CDH cases from Utah's statewide population-based surveillance program among the cohort of all pregnancy outcomes (live births, stillbirths, and pregnancy terminations) delivered from 1999 to 2011...
September 19, 2017: Birth defects research
https://www.readbyqxmd.com/read/28923508/generation-of-an-infectious-clone-of-amdv-and-identification-of-capsid-residues-essential-for-infectivity-in-cell-culture
#2
Ji Xi, Yanlong Zhang, Jigui Wang, Yongle Yu, Xiaomei Zhang, Zhaoda Li, Shangjin Cui, Weiquan Liu
Pathogenic strains of Aleutian mink disease virus (AMDV) such as Utah-1 do not replicate in cell culture (e.g., Crandell Rees feline kidney cells) while the in vitro-adapted AMDV strain ADV-Gorham (ADV-G) is not pathogenic. Here, we constructed a full-length infectious clone (pADV-G). Alignment of the VP2 gene of ADV-G with that of other AMDV strains revealed many amino acid (a.a.) residues conserved among pathogenic isolates that differed in ADV-G. Four virulence-associated, conserved residues of pADV-G VP2 were studied by site-directed mutagenesis (H92A, Q94S, Y115F, and I116L)...
September 15, 2017: Virus Research
https://www.readbyqxmd.com/read/28919319/a-population-based-description-of-familial-clustering-of-hirschsprung-s-disease
#3
Craig C Teerlink, Ryan Bernhisel, Lisa A Cannon-Albright, Michael D Rollins
BACKGROUND: Familial recurrence of Hirschsprung's disease (HSCR) is well documented, and risk estimates for relatives have been reported from various populations. We describe the familial clustering of HSCR cases using well-established unbiased familial aggregation techniques within the context of a population genealogy. METHODS: Patients included 264 HSCR cases identified using ICD-9 diagnosis coding from the two largest healthcare providers in Utah who also had linked genealogy data...
September 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28918154/hot-topic-geographical-distribution-and-strain-diversity-of-lactobacillus-wasatchensis-isolated-from-cheese-with-unwanted-gas-formation
#4
Michele Culumber, Donald J McMahon, Fatih Ortakci, Lauren Montierth, Beatriz Villalba, Jeffery R Broadbent, Craig J Oberg
Lactobacillus wasatchensis, an obligate heterofermentative nonstarter lactic acid bacteria (NSLAB) implicated in causing gas defects in aged cheeses, was originally isolated from an aged Cheddar produced in Logan, Utah. To determine the geographical distribution of this organism, we isolated slow-growing NSLAB from cheeses collected in different regions of the United States, Australia, New Zealand, and Ireland. Seven of the cheeses showed significant gas defects and 12 did not. Nonstarter lactic acid bacteria were isolated from these cheeses on de Man, Rogosa, and Sharpe medium supplemented with ribose, a preferred substrate for Lb...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917413/biocompatibility-of-intraocular-lens-power-adjustment-using-a-femtosecond-laser-in-a-rabbit-model
#5
Liliana Werner, Jason Ludlow, Jason Nguyen, Joah Aliancy, Larry Ha, Bryan Masino, Sean Enright, Ray K Alley, Ruth Sahler, Nick Mamalis
PURPOSE: To evaluate the biocompatibility (uveal and capsular) of intraocular lens (IOL) power adjustment by a femtosecond laser obtained through increased hydrophilicity of targeted areas within the optic, creating the ability to build a refractive-index shaping lens within an existing IOL. SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Six rabbits had phacoemulsification with bilateral implantation of a commercially available hydrophobic acrylic IOL...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28914273/patterns-and-appropriateness-of-thrombophilia-testing-in-an-academic-medical-center
#6
Nicholas Cox, Stacy A Johnson, Sara Vazquez, Ryan P Fleming, Matthew T Rondina, David Kaplan, Stephanie Chauv, Gabriel V Fontaine, Scott M Stevens, Scott Woller, Daniel M Witt
BACKGROUND: Clinical guidelines recommend against routine use of thrombophilia testing in patients with acute thromboembolism. Thrombophilia testing rarely changes acute management of a thrombotic event. OBJECTIVE: To determine appropriateness of thrombophilia testing in a teaching hospital. DESIGN: Retrospective cohort study. SETTING: One academic medical center in Utah. PARTICIPANTS: All patients who received thrombophilia testing between July 1, 2014, and December 31, 2014...
September 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28912114/understanding-the-natural-progression-of-spina-bifida-prospective-study
#7
Judy Thibadeau, Matthew R Reeder, Jennifer Andrews, Katherine Ong, Marcia L Feldkamp, Sydney Rice, Ann Alriksson-Schmidt
BACKGROUND: Spina bifida (SB) is monitored through birth defects surveillance across the United States and in most developed countries. Although much is known about the management of SB and its many comorbid conditions in affected individuals, there are few systematic, longitudinal studies on population-based cohorts of children or adults. The natural history of SB across the life course of persons with this condition is not well documented. Earlier identification of comorbidities and secondary conditions could allow for earlier intervention that might enhance the developmental trajectory for children with SB...
September 14, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28906138/in-vivo-effect-of-antibacterial-and-fluoride-releasing-adhesives-on-enamel-demineralization-around-brackets-a-micro-ct-study
#8
Aslihan Zeynep Oz, Abdullah Alper Oz, Sabahat Yazıcıoglu
OBJECTIVES: The aim of this in vivo study was to investigate the preventive effect of two different adhesives on enamel demineralization and compare these adhesives with a conventional one. MATERIALS AND METHODS: Fifteen patients requiring the extraction of their first four premolars for orthodontic treatment were included in the study. One premolar was randomly selected, and an antibacterial monomer-containing and fluoride-releasing adhesive (Clearfil Protect Bond, Kuraray Medical, Okayama, Japan) was used for orthodontic bracket bonding...
September 14, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28895829/in-utah-process-measures-are-winning-friends-influencing-outcomes
#9
Michael D Dalzell
Choosing the right blend of quality metrics for each DRG is one of the many intricacies of Value-Driven Outcomes (VDOs), Utah's answer to the challenge of how to "do" value-based care. An initiative five years in the making, VDO matches indicators of quality to DRGs with substantial variation in cost within Utah's own system.
July 2017: Managed Care
https://www.readbyqxmd.com/read/28882549/effect-of-knowledge-of-self-removability-of-intrauterine-contraceptives-on-uptake-continuation-and-satisfaction
#10
Sarah Raifman, Rana Barar, Diana Foster
OBJECTIVE: Preference for control over use is a consideration in choosing a contraceptive method. Counseling women on the possibility of intrauterine device (IUD) self-removal may increase interest in the method. This study tests whether counseling on self-removability as a stated feature of IUDs affects uptake, satisfaction, and continuation. STUDY DESIGN: We monitored clinic-level data on IUD uptake at clinics in Michigan, Missouri, New Jersey, and Utah over 6 months...
September 4, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28882255/improvement-of-the-performance-of-animal-crossing-warning-signs
#11
Majid Khalilikhah, Kevin Heaslip
INTRODUCTION: Animal-vehicle collisions (AVCs) can result in serious injury and death to drivers, animals' death, and significant economic costs. However, the cost effectiveness of the majority of AVC mitigation measures is a significant issue. METHOD: A mobile-based data collection effort was deployed to measure signs under the Utah Department of Transportation's (UDOT) jurisdiction. The crash data were obtained from the UDOT risk management database. ArcGIS was employed to link these two data sets and extract animal-related crashes and signs...
September 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28882227/left-atrial-fibrosis-and-risk-of-cerebrovascular-and-cardiovascular-events-in-patients-with%C3%A2-atrial-fibrillation
#12
MULTICENTER STUDY
Jordan B King, Peyman N Azadani, Promporn Suksaranjit, Adam P Bress, Daniel M Witt, Frederick T Han, Mihail G Chelu, Michelle A Silver, Joseph Biskupiak, Brent D Wilson, Alan K Morris, Eugene G Kholmovski, Nassir Marrouche
BACKGROUND: Severity of left atrial (LA) fibrosis is a strong predictor of atrial fibrillation (AF) ablation success and has been associated with a history of stroke, hypertension, and heart failure (HF). However, it is unclear whether more severe LA fibrosis independently increases the risk of major adverse cardiovascular and cerebrovascular events (MACCE) among those with AF. OBJECTIVES: The goal of this study was to evaluate the occurrence and frequency of MACCE by strata of LA fibrosis severity in patients with AF...
September 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28881586/identification-of-kansarl-as-the-first-cancer-predisposition-fusion-gene-specific-to-the-population-of-european-ancestry-origin
#13
Jeff Xiwu Zhou, Xiaoyan Yang, Shunbin Ning, Ling Wang, Kesheng Wang, Yanbin Zhang, Fenghua Yuan, Fengli Li, David D Zhuo, Liren Tang, Degen Zhuo
Gene fusion is one of the hallmarks of cancer. Recent advances in RNA-seq of cancer transcriptomes have facilitated the discovery of fusion transcripts. In this study, we report identification of a surprisingly large number of fusion transcripts, including six KANSARL (KANSL1-ARL17A) transcripts that resulted from the fusion between the KANSL1 and ARL17A genes using a RNA splicingcode model. Five of these six KANSARL fusion transcripts are novel. By systematic analysis of RNA-seq data of glioblastoma, prostate cancer, lung cancer, breast cancer, and lymphoma from different regions of the World, we have found that KANSARL fusion transcripts were rarely detected in the tumors of individuals from Asia or Africa...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880540/hydrocarbon-and-carbon-dioxide-fluxes-from-natural-gas-well-pad-soils-and-surrounding-soils-in-eastern-utah
#14
Seth N Lyman, Cody Watkins, Colleen Jones, Marc L Mansfield, Michael McKinley, Donna Kenney, Jordan Evans
We measured fluxes of methane, non-methane hydrocarbons, and carbon dioxide from natural gas well pad soils and from nearby undisturbed soils in eastern Utah. Methane fluxes varied from less than zero to more than 38 g m-2 h-1. Fluxes from well pad soils were almost always greater than from undisturbed soils. Fluxes were greater from locations with higher concentrations of total combustible gas in soil and were inversely correlated with distance from well heads. Several lines of evidence show that the majority of emission fluxes (about 70%) were primarily due to subsurface sources of raw gas that migrated to the atmosphere, with the remainder likely caused primarily by re-emission of spilled liquid hydrocarbons...
September 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28864935/program-and-abstracts-of-the-14th-transgenic-technology-meeting-tt2017-snowbird-resort-salt-lake-city-utah-usa-1-4-october-2017
#15
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Transgenic Research
https://www.readbyqxmd.com/read/28864404/toxicity-and-outcomes-in-patients-with-and-without-esophageal-stents-in-locally-advanced-esophageal-cancer
#16
Samual R Francis, Andrew Orton, Cameron Thorpe, Greg Stoddard, Shane Lloyd, Christopher J Anker
PURPOSE: Esophageal stenting is often considered to relieve dysphagia in patients with locoregionally advanced esophageal cancer. We sought to determine the effects of stenting on the incidence of acute toxicity and oncologic outcomes in patients undergoing chemoradiation therapy (CRT). METHODS AND MATERIALS: The data from patients treated with curative intent CRT for locoregionally advanced esophageal cancer at the University of Utah were retrospectively analyzed...
June 26, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28860045/the-effect-of-pulsing-on-transverse-ultrasound-efficiency-and-chatter
#17
Alex J Wright, Austin D Bohner, Ashlie A Bernhisel, Brian Zaugg, William R Barlow, Jeff H Pettey, Randall J Olson
PURPOSE: To evaluate the effects of micropulse, long pulse and continuous ultrasound on transverse ultrasound using Abbott Medical Optics' (AMO) WhiteStar Signature Pro with the Ellips FX handpiece. DESIGN: In vitro laboratory study METHODS: This study was conducted at the John A. Moran Eye Center Laboratory, University of Utah, Salt Lake City, UT, USA. Porcine lenses were hardened in formalin for 2 hours and equilibrated in BSS over a 24-hour period. The lenses were then cubed in 2...
August 28, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28854349/ranking-states-on-coverage-of-cancer-preventing-vaccines-among-adolescents-the-influence-of-imprecision
#18
Anne R Waldrop, Jennifer L Moss, Benmei Liu, Li Zhu
OBJECTIVES: Identifying the best and worst states for coverage of cancer-preventing vaccines (hepatitis B [HepB] and human papillomavirus [HPV]) may guide public health officials in developing programs, such as promotion campaigns. However, acknowledging the imprecision of coverage and ranks is important for avoiding overinterpretation. The objective of this study was to examine states' vaccination coverage and ranks, as well as the imprecision of these estimates, to inform public health decision making...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28851813/the-influential-role-of-bcl2-family-members-in-synovial-sarcomagenesis
#19
Jared J Barrott, Ju-Fen Zhu, Kyllie Smith-Fry, Asia M Susko, Dakota Nollner, Lance Burrell, Amir Pozner, Mario R Capecchi, Jeffrey T Yap, Lisa A Cannon-Albright, Xingming Deng, Kevin B Jones
Synovial sarcomas are deadly soft-tissue malignancies associated with t(X;18) balanced chromosomal translocations. Expression of the apoptotic regulator BCL2 is prominent in synovial sarcomas and has prompted the hypothesis that synovial sarcomagenesis may depend on it. Herein, it is demonstrated that Bcl2 overexpression enhances synovial sarcomagenesis in an animal model. Further, we determined increased familial clustering of human synovial sarcoma patients with victims of other BCL2-associated malignancies in the Utah Population Database...
August 29, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28842126/immediate-postpartum-levonorgestrel-intrauterine-device-insertion-and-breast-feeding-outcomes-a-noninferiority-randomized-controlled-trial
#20
David K Turok, Lawrence Leeman, Jessica N Sanders, Lauren Thaxton, Jennifer L Eggebroten, Nicole Yonke, Holly Bullock, Rameet Singh, Lori M Gawron, Eve Espey
BACKGROUND: Immediate postpartum levonorgestrel intrauterine device insertion is increasing in frequency in the United States, but few studies have investigated the effect of early placement on breast-feeding outcomes. OBJECTIVE: This study examined the effect of immediate vs delayed postpartum levonorgestrel intrauterine device insertion on breast-feeding outcomes. STUDY DESIGN: We conducted this noninferiority randomized controlled trial at the University of Utah and the University of New Mexico Health Sciences Centers from February 2014 through March 2016...
August 23, 2017: American Journal of Obstetrics and Gynecology
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