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https://www.readbyqxmd.com/read/28333301/preconception-maternal-lipoprotein-levels-in-relation-to-fecundability
#1
Sarah J Pugh, Enrique F Schisterman, Richard W Browne, Anne M Lynch, Sunni L Mumford, Neil J Perkins, Robert Silver, Lindsey Sjaarda, Joseph B Stanford, Jean Wactawski-Wende, Brian Wilcox, Katherine L Grantz
STUDY QUESTION: Are maternal preconception lipid levels associated with fecundability? SUMMARY ANSWER: Fecundability was reduced for all abnormal female lipid levels including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and total triglyceride levels. WHAT IS KNOWN ALREADY: Subfecundity affects 7-15% of the population and lipid disorders are hypothesized to play a role since cholesterol acts as a substrate for the synthesis of steroid hormones...
March 15, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28323483/taphonomy-of-microbial-biosignatures-in-spring-deposits-a-comparison-of-modern-quaternary-and-jurassic-examples
#2
Sally L Potter-McIntyre, Jason Williams, Charity Phillips-Lander, Laura O'Connell
On Earth, microorganisms commonly enhance mineral precipitation and mediate mineralogical and chemical compositions of resulting deposits, particularly at spring systems. However, preservation of any type of microbial fossil or chemical or textural biosignature depends on the degree of alteration during diagenesis and factors such as exposure to diagenetic fluids. Little is known about the transformation of biosignatures during diagenesis over geologic time. Ten Mile Graben, Utah, USA, hosts a cold spring system that is an exceptional site for evaluation of diagenetic alteration of biosignatures because of the presence of modern springs with actively precipitating microbial mats and a series of progressively older tufa terraces (<400 ka) preserved in the area from the same spring system...
March 2017: Astrobiology
https://www.readbyqxmd.com/read/28315031/feasibility-of-large-scale-identification-of-sessile-serrated-polyp-patients-using-electronic-records-a-utah-study
#3
Kajsa Affolter, Keith Gligorich, Niloy Jewel Samadder, Wade S Samowitz, Karen Curtin
BACKGROUND/AIMS: The serrated pathway accounts for 15-25% of sporadic colorectal cancer (CRC). In our study, we sought to accurately characterize sessile serrated polyps (SSP) in a population by electronically interrogating colonoscopy patients' endoscopy and pathology reports using a rules-based text search of pre-defined SSP-related terms. To this aim, we compared a sample of putative SSP and hyperplastic polyps (HP) using our algorithm to a determination of SSP or HP by pathologist and molecular examination to determine the feasibility of large-scale identification of SSP in electronic medical records...
March 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28290529/late-quaternary-faulting-in-the-sevier-desert-driven-by-magmatism
#4
T Stahl, N A Niemi
Seismic hazard in continental rifts varies as a function of strain accommodation by tectonic or magmatic processes. The nature of faulting in the Sevier Desert, located in eastern Basin and Range of central Utah, and how this faulting relates to the Sevier Desert Detachment low-angle normal fault, have been debated for nearly four decades. Here, we show that the geodetic signal of extension across the eastern Sevier Desert is best explained by magma-assisted rifting associated with Plio-Pleistocene volcanism...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275952/the-anticonvulsant-screening-program-of-the-national-institute-of-neurological-disorders-and-stroke-nih-history-and-contributions-to-clinical-care-in-the-twentieth-century-and-beyond
#5
Roger J Porter, Harvey J Kupferberg
The anticonvulsant screening program (ASP) of the national institute of neurological disorders and stroke (NINDS), National Institutes of Health has made substantial contributions to the drug armamentarium of the clinical neurologist. This program, originally a part of the overall Drug Development Program of the Epilepsy Branch, has been fortunate to have talented leadership, both at NINDS in Maryland and at the major contract site, the University of Utah-over a remarkable period of more than 40 years. Future discoveries by the ASP (now renamed the Epilepsy Therapy Screening) can be expected to make additional contributions to improving the health of persons with epilepsy...
March 9, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28269038/linear-methods-for-reducing-emg-contamination-in-peripheral-nerve-motor-decodes
#6
Zachary B Kagan, Suzanne Wendelken, David M Page, Tyler Davis, Douglas T Hutchinson, Gregory A Clark, David J Warren
Signals recorded from the peripheral nervous system (PNS) with high channel count penetrating microelectrode arrays, such as the Utah Slanted Electrode Array (USEA), often have electromyographic (EMG) signals contaminating the neural signal. This common-mode signal source may prevent single neural units from successfully being detected, thus hindering motor decode algorithms. Reducing this EMG contamination may lead to more accurate motor decode performance. A virtual reference (VR), created by a weighted linear combination of signals from a subset of all available channels, can be used to reduce this EMG contamination...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268963/big-data-challenges-in-decoding-cortical-activity-in-a-human-with-quadriplegia-to-inform-a-brain-computer-interface
#7
David A Friedenberg, Chad E Bouton, Nicholas V Annetta, Nicholas Skomrock, Mingming Zhang, Michael Schwemmer, Marcia A Bockbrader, W Jerry Mysiw, Ali R Rezai, Herbert S Bresler, Gaurav Sharma
Recent advances in Brain Computer Interfaces (BCIs) have created hope that one day paralyzed patients will be able to regain control of their paralyzed limbs. As part of an ongoing clinical study, we have implanted a 96-electrode Utah array in the motor cortex of a paralyzed human. The array generates almost 3 million data points from the brain every second. This presents several big data challenges towards developing algorithms that should not only process the data in real-time (for the BCI to be responsive) but are also robust to temporal variations and non-stationarities in the sensor data...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268671/on-comparing-in-vivo-intracranial-recordings-in-non-human-primates-to-predictions-of-optimized-transcranial-electrical-stimulation
#8
Abhishek Datta, Matthew R Krause, Praveen K Pilly, Jaehoon Choe, Theodoras P Zanos, Chris Thomas, Christopher C Pack
Transcranial electrical stimulation (tES) can be optimized to achieve maximal current flow at desired brain regions. The aim of this study was to characterize electric field magnitudes generated by tES optimization and to compare them to experimentally induced values as determined by data from intracranial electrodes. Local field potentials were recorded from two monkeys with implanted multi-site intracranial Utah arrays during transcranial direct current stimulation (tDCS), and the neural effect predictions obtained from optimized electrode placement were assessed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266244/psychopathological-temperamental-and-characteristic-factors-in-adults-with-remaining-childhood-attention-deficit-hyperactivity-symptoms
#9
Kyoung Min Kim, Sojeong Nam, Soo Yeon Kim, Soo Min Lee, Jae-Won Choi, Taewoong Kang, Jun Won Kim
OBJECTIVES: To investigate differences in psychopathological, temperamental and characteristic factors between young adults with and without persistent Attention-Deficit Hyperactivity disorder (ADHD) symptoms. METHODS: A total of 429 university students were divided into three groups: persistent adult ADHD (n = 53), only childhood ADHD (n = 56) and healthy controls (n = 320). The Korean Adult ADHD Scale, Korean Wender-Utah Rating Scale, Beck Depression Inventory-II, Beck Anxiety Inventory, Barratt Impulsiveness Scale, Korean Young Internet Addiction Scale, and Temperament Character Inventory-Revised (TCI-R; based on Cloninger's seven factor model of temperament and character) were used to evaluate psychopathological factors...
March 7, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28265235/safety-and-efficacy-of-doxorubicin-eluting-superabsorbent-polymer-microspheres-for-the-treatment-of-liver-metastases-from-neuroendocrine-tumours-preliminary-results
#10
Lawrence Bonne, Chris Verslype, Annouschka Laenen, Sandra Cornelissen, Christophe M Deroose, Hans Prenen, Vincent Vandecaveye, Eric Van Cutsem, Geert Maleux
BACKGROUND: The aim of the study was to retrospectively evaluate the symptom control, tumour response, and complication rate in patients with liver-predominant metastatic neuroendocrine tumours treated with transarterial chemoembolization using doxorubicin-eluting superabsorbent polymer (SAP) microspheres. PATIENTS AND METHODS: Patients with neuroendocrine liver metastases who underwent hepatic transarterial chemoembolization using doxorubicin-eluting SAP-microspheres (50-100 μm Hepasphere/Quadrasphere Microsphere® particles, Merit Medical, South Jordan, Utah, USA) were included in this study...
March 1, 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28251421/younger-age-and-health-beliefs-associated-with-being-overdue-for-pap-testing-among-utah-latinas-who-were-non-adherent-to-cancer-screening-guidelines
#11
Djin Lai, Julia Bodson, Echo L Warner, Shauna Ayres, Ryan Mooney, Deanna Kepka
Factors associated with being overdue for Papanicoloau (Pap) testing in a Latina community were examined. Female participants aged ≥ 21 years, who were overdue for one or more cancer screenings (N = 206), were purposively recruited. Descriptive statistics, Fisher's Exact Tests for count data, and multivariable logistic regressions were conducted. Participants overdue for cancer screening, aged 38-47 years demonstrated lower odds of being overdue for Pap testing compared with those 21-37 years old (OR = 0...
March 1, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28230564/attention-deficit-hyperactivity-disorder-aggression-and-illicit-stimulant-use-is-this-self-medication
#12
Annie P Odell, Grace L Reynolds, Dennis G Fisher, Loucine M Huckabay, William C Pedersen, Pamela Xandre, Milica Miočević
This study compares adults with and without attention deficit hyperactivity disorder (ADHD) on measures of direct and displaced aggression and illicit drug use. Three hundred ninety-six adults were administered the Wender Utah Rating Scale, the Risk Behavior Assessment, the Aggression Questionnaire (AQ), and the Displaced Aggression Questionnaire (DAQ). Those with ADHD were higher on all scales of the AQ and DAQ, were younger at first use of amphetamines, and were more likely to have ever used crack and amphetamines...
February 22, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28227252/linear-methods-for-reducing-emg-contamination-in-peripheral-nerve-motor-decodes
#13
Zachary B Kagan, Suzanne Wendelken, David M Page, Tyler Davis, Douglas T Hutchinson, Gregory A Clark, David J Warren, Zachary B Kagan, Suzanne Wendelken, David M Page, Tyler Davis, Douglas T Hutchinson, Gregory A Clark, David J Warren, Gregory A Clark, Zachary B Kagan, David J Warren, David M Page, Suzanne Wendelken, Tyler Davis, Douglas T Hutchinson
Signals recorded from the peripheral nervous system (PNS) with high channel count penetrating microelectrode arrays, such as the Utah Slanted Electrode Array (USEA), often have electromyographic (EMG) signals contaminating the neural signal. This common-mode signal source may prevent single neural units from successfully being detected, thus hindering motor decode algorithms. Reducing this EMG contamination may lead to more accurate motor decode performance. A virtual reference (VR), created by a weighted linear combination of signals from a subset of all available channels, can be used to reduce this EMG contamination...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227170/big-data-challenges-in-decoding-cortical-activity-in-a-human-with-quadriplegia-to-inform-a-brain-computer-interface
#14
David A Friedenberg, Chad E Bouton, Nicholas V Annetta, Nicholas Skomrock, Mingming Zhang, Michael Schwemmer, Marcia A Bockbrader, W Jerry Mysiw, Ali R Rezai, Herbert S Bresler, Gaurav Sharma, David A Friedenberg, Chad E Bouton, Nicholas V Annetta, Nicholas Skomrock, Mingming Zhang, Michael Schwemmer, Marcia A Bockbrader, W Jerry Mysiw, Ali R Rezai, Herbert S Bresler, Gaurav Sharma, Nicholas Skomrock, David A Friedenberg, Marcia A Bockbrader, Chad E Bouton, Ali R Rezai, Mingming Zhang, Herbert S Bresler, Gaurav Sharma, W Jerry Mysiw, Nicholas V Annetta, Michael Schwemmer
Recent advances in Brain Computer Interfaces (BCIs) have created hope that one day paralyzed patients will be able to regain control of their paralyzed limbs. As part of an ongoing clinical study, we have implanted a 96-electrode Utah array in the motor cortex of a paralyzed human. The array generates almost 3 million data points from the brain every second. This presents several big data challenges towards developing algorithms that should not only process the data in real-time (for the BCI to be responsive) but are also robust to temporal variations and non-stationarities in the sensor data...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226855/on-comparing-in-vivo-intracranial-recordings-in-non-human-primates-to-predictions-of-optimized-transcranial-electrical-stimulation
#15
Abhishek Datta, Matthew R Krause, Praveen K Pilly, Jaehoon Choe, Theodoras P Zanos, Chris Thomas, Christopher C Pack, Abhishek Datta, Matthew R Krause, Praveen K Pilly, Jaehoon Choe, Theodoras P Zanos, Chris Thomas, Christopher C Pack, Jaehoon Choe, Chris Thomas, Theodoros P Zanos, Abhishek Datta, Praveen K Pilly, Christopher C Pack, Matthew R Krause
Transcranial electrical stimulation (tES) can be optimized to achieve maximal current flow at desired brain regions. The aim of this study was to characterize electric field magnitudes generated by tES optimization and to compare them to experimentally induced values as determined by data from intracranial electrodes. Local field potentials were recorded from two monkeys with implanted multi-site intracranial Utah arrays during transcranial direct current stimulation (tDCS), and the neural effect predictions obtained from optimized electrode placement were assessed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28213544/isolation-and-characterization-of-a-unique-strain-of-rickettsia-parkeri-associated-with-the-hard-tick-dermacentor-parumapertus-neumann-in-the-western-united-states
#16
Christopher D Paddock, Michelle E J Allerdice, Sandor E Karpathy, William L Nicholson, Michael L Levin, Travis C Smith, Tom Becker, Robert J Delph, Robert N Knight, Jana M Ritter, Jeanine H Sanders, Jerome Goddard
In 1953, investigators at the Rocky Mountain Laboratories in Hamilton, Montana, described the isolation of a spotted fever group Rickettsia (SFGR) species from Dermacentor parumapertus collected from black-tailed jackrabbits (Lepus californicus) in northern Nevada. Several decades later, investigators characterized this SFGR by using mouse serotyping methods and determined that it represented a distinct rickettsial serotype, related closely to Rickettsia parkeri; nonetheless, the parumapertus agent was not further characterized or studied...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28211155/utah-obstetricians-opinions-of-planned-home-birth-and-conflicting-nice-acog-guidelines-a-qualitative-study
#17
Emily Rainey, Sara Simonsen, Joseph Stanford, Kimberley Shoaf, Jami Baayd
BACKGROUND: The United Kingdom's National Institute for Health and Care Excellence (NICE) recently published recommendations that support planned home birth for low-risk women. The American College of Obstetricians and Gynecologists (ACOG) remains wary of planned home birth, asserting that hospitals and birthing centers are the safest birth settings. Our objective was to examine opinions of obstetricians in Salt Lake City, Utah about home birth in the context of rising home birth rates and conflicting guidelines...
February 17, 2017: Birth
https://www.readbyqxmd.com/read/28192145/population-based-familial-aggregation-of-eosinophilic-esophagitis-suggests-a-genetic-contribution
#18
Kristina Allen-Brady, Rafael Firszt, John C Fang, Jathine Wong, Ken R Smith, Kathryn A Peterson
BACKGROUND: Prior familial clustering studies have observed an increased risk of eosinophilic esophagitis (EoE) mostly among first-degree relatives, suggesting a genetic contribution to EoE, and twin studies have suggested a powerful contribution from environmental factors. OBJECTIVE: This study sought to clarify the contribution of genetic factors to EoE through estimation of familial aggregation and risk of EoE in extended relatives. METHODS: The Utah Population Database, a population-based genealogy resource linked to electronic medical records for health care systems across the state of Utah, was used to identify EoE cases and age, sex, and birthplace-matched controls at a 5:1 ratio...
February 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28188772/two-year-continuation-of-intrauterine-devices-and%C3%A2-contraceptive-implants-in-a-mixed-payer-setting-%C3%A2-a%C3%A2-retrospective-review
#19
Jessica N Sanders, David K Turok, Lori M Gawron, Amy Law, Lonnie Wen, Richard Lynen
BACKGROUND: As the popularity of long-acting reversible contraception increases, so does the need for accurate data on method continuation in diverse clinical settings. We determined 2-year continuation rates for the levonorgestrel 52-mg intrauterine device, the copper T380A intrauterine device, and the 68-mg etonogestrel contraceptive implant in an academic healthcare system with mixed-payer reimbursement. OBJECTIVE: The purpose of this study was to examine the proportion and characteristics of women who continue intrauterine device and implant use to 2 years and to relate continuation to device type when controlling for patient characteristics...
February 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28183312/psychometric-properties-of-the-press-ganey%C3%A2-outpatient-medical-practice-survey
#20
Angela P Presson, Chong Zhang, Amir M Abtahi, Jacob Kean, Man Hung, Andrew R Tyser
BACKGROUND: The Press Ganey® Medical Practice Survey ("Press Ganey® survey") is a patient-reported questionnaire commonly used to measure patient satisfaction with outpatient health care in the United States. Our objective was to evaluate the reliability and validity of the Press Ganey® survey in a single institution setting. METHODS: We analyzed surveys from 34,503 unique respondents seen by 624 providers from 47 specialties and 94 clinics at the University of Utah in 2013...
February 10, 2017: Health and Quality of Life Outcomes
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