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https://www.readbyqxmd.com/read/27913413/new-arsenate-reductase-gene-arra-pcr-primers-for-diversity-assessment-and-quantification-in-environmental-samples
#1
Babur S Mirza, Darwin L Sorensen, R Ryan Dupont, Joan E McLean
: The extent of arsenic contamination in drinking water and its potential threat to human health have resulted in considerable research interest in the microbial species responsible for arsenic reduction. The arsenate reductase gene (arrA), an important component of the microbial arsenate reduction system, has been widely used as a biomarker to study arsenate reducing microorganisms. A new primer pair was designed and evaluated for qPCR and high-throughput sequencing of the arrA gene, because currently available PCR primers are not suitable for these applications...
December 2, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27905996/type-2-diabetes-detection-and-management-among-insured-adults
#2
Timothy M Dall, Weyna Yang, Pragna Halder, Jerry Franz, Erin Byrne, April P Semilla, Ritashree Chakrabarti, Bruce Stuart
BACKGROUND: The Centers for Disease Control and Prevention estimates that 28.9 million adults had diabetes in 2012 in the US, though many patients are undiagnosed or not managing their condition. This study provides US national and state estimates of insured adults with type 2 diabetes who are diagnosed, receiving exams and medication, managing glycemic levels, with diabetes complications, and their health expenditures. Such information can be used for benchmarking and to identify gaps in diabetes detection and management...
November 21, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905671/long-term-survivors-of-childhood-bone-and-soft-tissue-sarcomas-are-at-risk-of-hospitalization
#3
Cristian D Gonzalez, R Lor Randall, Jennifer Wright, Holly Spraker-Perlman, Jian Ying, Carol Sweeney, Ken R Smith, Anne C Kirchhoff
BACKGROUND: Childhood cancer survivors can have a high burden of chronic conditions related to cancer treatment, some of which are debilitating or potentially life-threatening. Much remains to be learned about late effects in bone and soft tissue sarcoma survivors. PROCEDURES: The Utah Cancer Registry was used to identify survivors of bone (N = 71) and soft tissue sarcomas (N = 98) who were diagnosed at ages 0-20 years between 1973 and 2007 and were alive at least 5 years after diagnosis...
December 1, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27903084/assessment-of-corticosteroid-related-quality-of-care-measures-for-uc-and-cd-in-the-united-states-a-claims-data-analysis
#4
David T Rubin, Haridarshan Patel, Sherry Shi, Reema Mody
OBJECTIVE: To evaluate corticosteroid (CS)-related quality of care indicators in patients with ulcerative colitis (UC) and Crohn's disease (CD) in the US. METHODS: Adults diagnosed with UC or CD and prescription fills for an oral CS were identified from a large commercial US claims database (2005- 2013). Quality indicators included prolonged CS use (≥60 days), use of CS-sparing therapy, and bone loss assessment. State-level variations in quality of care indicators were estimated using logistic regression models adjusting for age, gender, insurance plan type, and CD severity...
December 1, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27895533/type-2-diabetes-detection-and-management-among-insured-adults
#5
Timothy M Dall, Weyna Yang, Pragna Halder, Jerry Franz, Erin Byrne, April P Semilla, Ritashree Chakrabarti, Bruce Stuart
BACKGROUND: The Centers for Disease Control and Prevention estimates that 28.9 million adults had diabetes in 2012 in the US, though many patients are undiagnosed or not managing their condition. This study provides US national and state estimates of insured adults with type 2 diabetes who are diagnosed, receiving exams and medication, managing glycemic levels, with diabetes complications, and their health expenditures. Such information can be used for benchmarking and to identify gaps in diabetes detection and management...
2016: Population Health Metrics
https://www.readbyqxmd.com/read/27891786/a-quality-assessment-of-reporting-sources-for-microcephaly-in-utah-2003-to-2013
#6
Amy Steele, Jane Johnson, Amy Nance, Robert Satterfield, C J Alverson, Cara Mai
BACKGROUND: Obtaining accurate microcephaly prevalence is important given the recent association between microcephaly and Zika virus. Assessing the quality of data sources can guide surveillance programs as they focus their data collection efforts. The Utah Birth Defect Network (UBDN) has monitored microcephaly by data sources since 2003. The objective of this study was to examine the impact of reporting sources for microcephaly surveillance. METHODS: All reported cases of microcephaly among Utah mothers from 2003 to 2013 were clinically reviewed and confirmed...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27891635/potential-association-between-drug-shortages-and-high-cost-medications
#7
Erin R Fox, Linda S Tyler
Shortages and sudden price increases of certain drugs may both occur emergently, with little to no warning, and they can have a dramatic impact on patient care. Little data are available linking drug shortages and price increases. Many of the same characteristics that may make medications susceptible to shortages can also place them at risk for sudden price increases. These characteristics include unapproved drugs, off-patent sole-source medications, and infrequently used medications. We reviewed drug shortage data from the University of Utah Drug Information Service to demonstrate how frequently these characteristics occurred and resulted in higher drug prices...
November 5, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27882292/muscular-strength-and-endurance-and-cardio-metabolic-health-in-disadvantaged-hispanic-children-from-the-u-s
#8
Ryan D Burns, Timothy A Brusseau
The predictive relationship between muscular strength and endurance and cardio-metabolic health, independent from aerobic fitness, is not clear in disadvantaged Hispanic children. The purpose of this study was to examine the predictive relationship between muscular strength and endurance and clustered cardio-metabolic risk, controlling for aerobic fitness, in Hispanic children from low-income schools. Participants were 320 Hispanic children (Mean age = 10.1 ± 1.1 years; 164 girls, 156 boys) recruited during the 2014-2015 and 2015-2016 academic years from five low-income schools from the state of Utah in the U...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27811667/the-harvestman-genus-taracus-simon-1879-and-the-new-genus-oskoron%C3%A2-opiliones-ischyropsalidoidea-taracidae
#9
William A Shear, Joseph G Warfel
The ischyropsalidoid genus Taracus Simon 1879 is reviewed and all previously named species are redescribed. Taracus nigripes Goodnight & Goodnight, 1943 is synonymized with T. packardi Simon 1879, and T. malkini Goodnight & Goodnight 1945 with Oskoron spinosus (Banks) 1894; the type locality of T. gertschi Goodnight & Goodnight 1942 is corrected from "eastern Oregon" to Rose Lake, Idaho, based on original labelling. The following new species of Taracus are described: T. carmanah (Vancouver Island), T. marchingtoni (Oregon), T...
November 1, 2016: Zootaxa
https://www.readbyqxmd.com/read/27798986/chiari-related-hydrocephalus-assessment-of-clinical-risk-factors-in-a-cohort-of-297-consecutive-patients
#10
Jian Guan, Jay Riva-Cambrin, Douglas L Brockmeyer
OBJECTIVE Patients treated for Chiari I malformation (CM-I) with posterior fossa decompression (PFD) may occasionally and unpredictably develop postoperative hydrocephalus. The clinical risk factors predictive of this type of Chiari-related hydrocephalus (CRH) are unknown. The authors' objective was to evaluate their experience to identify risk factors that may predict which of these patients undergoing PFD will develop CRH after surgery. METHODS The authors performed a retrospective clinical chart review of all patients who underwent PFD surgery and duraplasty for CM-I at the Primary Children's Hospital in Utah from June 1, 2005, through May 31, 2015...
November 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27795338/clinical-microbiology-laboratories-adoption-of-culture-independent-diagnostic-tests-are-a-threat-to-food-borne-disease-surveillance-in-the-united-states
#11
Shari Shea, Kristy A Kubota, Hugh Maguire, Stephen Gladbach, Amy Woron, Robyn Atkinson-Dunn, Marc Roger Couturier, Melissa B Miller
In November, 2015, the Centers for Disease Control and Prevention (CDC) sent a letter to State and Territorial epidemiologists, State and Territorial public health laboratory directors, and State and Territorial health officials. In this letter, culture independent diagnostic tests (CIDTs) for detection for enteric pathogens were characterized as "a serious and current threat to public health surveillance, particularly for Shiga toxin-producing E. coli (STEC) and Salmonella." The document says CDC and its public health partners are approaching this issue, in part, by "reviewing regulatory authority in public health agencies to require culture isolates or specimen submission if CIDTs are used...
October 19, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27792857/sudden-infant-death-syndrome-insights-and-future-directions-from-a-utah-population-database-analysis
#12
Erik D Christensen, Justin Berger, Mouied M Alashari, Hilary Coon, Cynthia Robison, Hsu-Tso Ho, David R Adams, Willian A Gahl, Ken R Smith, John M Opitz, Dennis R Johnson
"Sudden Infant Death syndrome" (SIDS) represents the commonest category of infant death after the first month of life. As genome scale sequencing greatly facilitates the identification of new candidate disease variants, the challenges of ascribing causation to these variants persists. In order to determine the extent to which SIDS occurs in related individuals and their pedigree structure we undertook an analysis of SIDS using the Utah Population Database, recording, for example, evidence of enrichment for genetic causation following the back-to-sleep recommendations of 1992 and 1994...
October 28, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27783632/mountain-pine-beetle-dynamics-and-reproductive-success-in-post-fire-lodgepole-and-ponderosa-pine-forests-in-northeastern-utah
#13
Andrew P Lerch, Jesse A Pfammatter, Barbara J Bentz, Kenneth F Raffa
Fire injury can increase tree susceptibility to some bark beetles (Curculionidae, Scolytinae), but whether wildfires can trigger outbreaks of species such as mountain pine beetle (Dendroctonus ponderosae Hopkins) is not well understood. We monitored 1173 lodgepole (Pinus contorta var. latifolia Doug.) and 599 ponderosa (Pinus ponderosa Doug. ex Law) pines for three years post-wildfire in the Uinta Mountains of northeastern Utah in an area with locally endemic mountain pine beetle. We examined how the degree and type of fire injury influenced beetle attacks, brood production, and subsequent tree mortality, and related these to beetle population changes over time...
2016: PloS One
https://www.readbyqxmd.com/read/27779603/lumbar-fusion-in-utah-workers-compensation-patients-changing-outcomes-across-a-decade
#14
Jessica Gundy Cuneo, M Scott DeBerard, Anthony J Wheeler
STUDY DESIGN: This study was a retrospective-cohort design involving a review of patient medical and cost records and a 2-year post surgery follow-up outcome survey. OBJECTIVE: To evaluate the functional and cost outcomes associated with recent lumbar fusion surgeries in Utah workers and compare these outcomes with a comparable prior study cohort. SUMMARY OF BACKGROUND DATA: Lumbar fusion performed on injured workers has dramatically increased over the past two decades and this likely coincided with the increased use of more advanced surgical instrumentation...
October 24, 2016: Spine
https://www.readbyqxmd.com/read/27775761/state-level-cancer-mortality-attributable-to-cigarette-smoking-in-the-united-states
#15
Joannie Lortet-Tieulent, Ann Goding Sauer, Rebecca L Siegel, Kimberly D Miller, Farhad Islami, Stacey A Fedewa, Eric J Jacobs, Ahmedin Jemal
Importance: State-specific information about the health burden of smoking is valuable because state-level initiatives are at the forefront of tobacco control. Smoking-attributable cancer mortality estimates are currently available nationally and by cancer, but not by state. Objective: To calculate the proportion of cancer deaths among adults 35 years and older that were attributable to cigarette smoking in 2014 in each state and the District of Columbia. Design, Setting, and Participants: The population-attributable fraction (PAF) of cancer deaths due to cigarette smoking was computed using relative risks for 12 smoking-related cancers (acute myeloid leukemia and cancers of the oral cavity and pharynx; esophagus; stomach; colorectum; liver; pancreas; larynx; trachea, lung, and bronchus; cervix uteri; kidney and renal pelvis; and urinary bladder) from large US prospective studies and state-specific smoking prevalence data from the Behavioral Risk Factor Surveillance System...
October 24, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27774813/cognitive-distortions-and-adhd-in-pathological-gambling-a-national-longitudinal-case-control-cohort-study
#16
Lucia Romo, Cindy Legauffre, Alice Guilleux, Marc Valleur, David Magalon, Mélina Fatséas, Isabelle Chéreau-Boudet, Amandine Luquiens, Jean-Luc Vénisse, Marie Grall-Bronnec, Gaëlle Challet-Bouju
Introduction The primary outcome of our study was to assess the links between the level of cognitive distortions and the severity of gambling disorder. We also aimed at assessing the links between patient gambling trajectories and attention deficit and hyperactivity disorder (ADHD). Materials and methods The study population (n = 628) was comprised of problem and non-problem gamblers of both sexes between 18 and 65 years of age, who reported gambling on at least one occasion during the previous year. Data encompassed socio-demographic characteristics, gambling habits, the South Oaks Gambling Screen, the Gambling Attitudes and Beliefs Survey - 23, the Wender Utah Rating Scale - Child, and the Adult ADHD Self-report Scale...
October 24, 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/27768509/adolescent-and-young-adult-cancer-survivors-valuation-of-post-treatment-recommended-care
#17
Sapna Kaul, Rochelle R Smits-Seemann, Eduardo R Zamora, Holly Spraker-Perlman, Kevin J Boyle, Anne C Kirchhoff
PURPOSE: Examine whether survivors of adolescent and young adult (AYA) cancer value recommended post-treatment care using focus groups and a willingness to pay (WTP) survey. WTP, a measure of value, indicates the dollar amount individuals are willing to pay to use a service. METHODS: Participants were recruited through the Utah Cancer Registry. N = 28 survivors diagnosed with cancer at ages 15-39 and currently aged ≥18 participated in focus groups, and N = 4 in phone interviews (participation rate = 50%)...
October 21, 2016: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27764177/development-validation-and-field-testing-of-an-instrument-for-clinical-assessment-of-hiv-associated-neuropathy-and-neuropathic-pain-in-resource-restricted-and-large-population-study-settings
#18
Yohannes W Woldeamanuel, Peter R Kamerman, Demetri G A Veliotes, Tudor J Phillips, David Asboe, Marta Boffito, Andrew S C Rice
HIV-associated sensory peripheral neuropathy (HIV-SN) afflicts approximately 50% of patients on antiretroviral therapy, and is associated with significant neuropathic pain. Simple accurate diagnostic instruments are required for clinical research and daily practice in both high- and low-resource setting. A 4-item clinical tool (CHANT: Clinical HIV-associated Neuropathy Tool) assessing symptoms (pain and numbness) and signs (ankle reflexes and vibration sense) was developed by selecting and combining the most accurate measurands from a deep phenotyping study of HIV positive people (Pain In Neuropathy Study-HIV-PINS)...
2016: PloS One
https://www.readbyqxmd.com/read/27762237/clinical-applications-of-penetrating-neural-interfaces-and-utah-electrode-array-technologies
#19
Richard A Normann, Eduardo Fernandez
This paper briefly describes some of the recent progress in the development of penetrating microelectrode arrays and highlights the use of two of these devices, Utah electrode arrays and Utah slanted electrode arrays, in two therapeutic interventions: recording volitional skeletal motor commands from the central nervous system, and recording motor commands and evoking somatosensory percepts in the peripheral nervous system (PNS). The paper also briefly explores other potential sites for microelectrode array interventions that could be profitably pursued and that could have important consequences in enhancing the quality of life of patients that has been compromised by disorders of the central and PNSs...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27760738/the-framework-for-population-epigenetic-study
#20
Linna Zhao, Di Liu, Jing Xu, Zhaoyang Wang, Yang Chen, Changgui Lei, Ying Li, Guiyou Liu, Yongshuai Jiang
At present, understanding of DNA methylation at the population level is still limited. Here, we first extended the classical framework of population genetics, such as single nucleotide polymorphism allele frequency, linkage disequilibrium (LD), LD block and haplotype, to epigenetics. Then, as an example, we compared the DNA methylation disequilibrium (MD) maps between HapMap CEU (Caucasian residents of European ancestry from Utah) population and YRI (Yoruba people from Ibadan) population (lymphoblastoid cell lines)...
October 19, 2016: Briefings in Bioinformatics
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