keyword
MENU ▼
Read by QxMD icon Read
search

Swift prime

keyword
https://www.readbyqxmd.com/read/27781037/rescue-thrombectomy-in-large-vessel-occlusion-strokes-leads-to-better-outcomes-than-intravenous-thrombolysis-alone-a-real-world-applicability-of-the-recent-trials
#1
Raul G Nogueira, Osama O Zaidat, Alicia C Castonguay, Diogo C Haussen, Coleman O Martin, William E Holloway, Nils Mueller-Kronast, Joey English, Italo Linfante, Guilherme Dabus, Tim W Malisch, Franklin A Marden, Hormozd Bozorgchami, Andrew Xavier, Ansaar T Rai, Michael T Froehler, Aamir Badruddin, Thanh N Nguyen, M Asif Taqi, Michael G Abraham, Vallabh Janardhan, Albert J Yoo, Hashem Shaltoni, Alex Abou-Chebl, Peng R Chen, Gavin W Britz, Roberta Novakovic, Ashish Nanda, Ritesh Kaushal, Mohammad A Issa, Michael R Frankel, Rishi Gupta
BACKGROUND: The Interventional Management of Stroke III (IMS-III) trial demonstrated no benefit for intravenous recombinant tissue plasminogen activator (IV rt-PA) followed by endovascular therapy versus IV rt-PA alone. However, IMS-III mostly included earlier generation devices. The recent thrombectomy trials have incorporated the stent-retriever technology, but their generalizability remains unknown. METHODS: The North American Solitaire Acute Stroke (NASA) registry recruited patients treated with the Solitaire FR™ device between March 2012 and February 2013...
September 2016: Interventional Neurology
https://www.readbyqxmd.com/read/27758942/cost-effectiveness-of-endovascular-stroke-therapy-a-patient-subgroup-analysis-from-a-us-healthcare-perspective
#2
Wolfgang G Kunz, M G Myriam Hunink, Wieland H Sommer, Sebastian E Beyer, Felix G Meinel, Franziska Dorn, Stefan Wirth, Maximilian F Reiser, Birgit Ertl-Wagner, Kolja M Thierfelder
BACKGROUND AND PURPOSE: Endovascular therapy in addition to standard care (EVT+SC) has been demonstrated to be more effective than SC in acute ischemic large vessel occlusion stroke. Our aim was to determine the cost-effectiveness of EVT+SC depending on patients' initial National Institutes of Health Stroke Scale (NIHSS) score, time from symptom onset, Alberta Stroke Program Early CT Score (ASPECTS), and occlusion location. METHODS: A decision model based on Markov simulations estimated lifetime costs and quality-adjusted life years (QALYs) associated with both strategies applied in a US setting...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27664152/endovascular-treatment-of-thrombosis-and-embolism
#3
Ahmet Yigit Goktay, Cagin Senturk
Deep venous thrombosis (DVT) is a common disorder with a significant mortality rate. Successful endovascular treatment of acute DVT is most likely to be achieved in patients with recently formed thrombus, (<10-14 days) with acute iliofemoral DVT. Endovascular treatment options include: Catheter-directed thrombolysis (CDT), pharmacomechanical catheter-directed thrombolysis (PCDT), percutaneous aspiration thrombectomy (PAT), vena cava filter protection, venous balloon dilatation and venous stent implantation...
September 24, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27634952/association-of-clot-burden-score-with-radiographic-and-clinical-outcomes-following-solitaire-stent-retriever-thrombectomy-analysis-of-the-swift-prime-trial
#4
Maxim Mokin, Elad I Levy, Adnan H Siddiqui, Mayank Goyal, Raul G Nogueira, Dileep R Yavagal, Vitor M Pereira, Jeffrey L Saver
BACKGROUND: The clot burden score (CBS) was developed as a tool to evaluate the extent of intracranial thrombus burden in patients with anterior circulation acute ischemic stroke. CBS is based on the presence or absence of contrast opacification on CT angiography (CTA). Its value in predicting radiographic and clinical outcomes in patients given endovascular stroke therapy remains unknown. OBJECTIVE: To evaluate the relationship between CBS and outcomes after stent retriever thrombectomy in the interventional arm of the SWIFT PRIME trial...
September 15, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27610120/systematic-review-and-pooled-analyses-of-recent-neurointerventional-randomized-controlled-trials-setting-a-new-standard-of-care-for-acute-ischemic-stroke-treatment-after-20-years
#5
Mohammed Hussain, Mohammad Moussavi, Daniel Korya, Siddhart Mehta, Jaskiran Brar, Harina Chahal, Ihtesham Qureshi, Tapan Mehta, Javaad Ahmad, Osama O Zaidat, Jawad F Kirmani
BACKGROUND: Recent advances in the treatment of ischemic stroke have focused on revascularization and led to better clinical and functional outcomes. A systematic review and pooled analyses of 6 recent multicentered prospective randomized controlled trials (MPRCT) were performed to compare intravenous tissue plasminogen activator (IV tPA) and endovascular therapy (intervention) with IV tPA alone (control) for anterior circulation ischemic stroke (AIS) secondary to large vessel occlusion (LVO)...
June 2016: Interventional Neurology
https://www.readbyqxmd.com/read/27529062/prion-diseases-immunotargets-and-therapy
#6
REVIEW
Jennifer T Burchell, Peter K Panegyres
Transmissible spongiform encephathalopathies or prion diseases are a group of neurological disorders characterized by neuronal loss, spongiform degeneration, and activation of astrocytes or microglia. These diseases affect humans and animals with an extremely high prevalence in some species such as deer and elk in North America. Although rare in humans, they result in a devastatingly swift neurological progression with dementia and ataxia. Patients usually die within a year of diagnosis. Prion diseases are familial, sporadic, iatrogenic, or transmissible...
2016: ImmunoTargets and Therapy
https://www.readbyqxmd.com/read/27382268/methods-to-reduce-prescribing-errors-in-elderly-patients-with-multimorbidity
#7
REVIEW
Amanda H Lavan, Paul F Gallagher, Denis O'Mahony
The global population of multimorbid older people is growing steadily. Multimorbidity is the principal cause of complex polypharmacy, which in turn is the prime risk factor for inappropriate prescribing and adverse drug reactions and events. Those who prescribe for older frailer multimorbid people are particularly prone to committing prescribing errors of various kinds. The causes of prescribing errors in this patient population are multifaceted and complex, including prescribers' lack of knowledge of aging physiology, geriatric medicine, and geriatric pharmacotherapy, overprescribing that frequently leads to major polypharmacy, inappropriate prescribing, and inappropriate drug omission...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27366977/landmark-papers-in-cerebrovascular-neurosurgery-2015
#8
REVIEW
Justin M Moore, Christoph J Griessenauer, Raghav Gupta, Nimer Adeeb, Apar S Patel, Christopher S Ogilvy, Ajith J Thomas
The management of cerebrovascular disease has advanced considerably in 2015. Five randomized control trials have firmly established the role of endovascular thrombectomy for ischemic strokes due to large vessel occlusion. The randomized trial of intraarterial treatment for acute ischemic stroke (MR CLEAN) (Berkhemer et al. NEJM 2015;372:11-20) was the first of a series on the topic. There was a total of 5 randomized controlled trials published showing benefit in terms of functional outcomes at 90days for mechanical thrombectomy including the Endovascular Therapy for Ischemic stroke with perfusion-imaging selection (EXTEND IA) (Campbell et al...
September 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27325355/thrombectomy-for-ischemic-stroke-meta-analyses-of-recurrent-strokes-vasospasms-and-subarachnoid-hemorrhages
#9
Robert Emprechtinger, Brigitte Piso, Peter A Ringleb
Mechanical thrombectomy with stent retrievers is an effective treatment for patients with ischemic stroke. Results of recent meta-analyses report that the treatment is safe. However, the endpoints recurrent stroke, vasospasms, and subarachnoid hemorrhage have not been evaluated sufficiently. Hence, we extracted data on these outcomes from the five recent thrombectomy trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA published in 2015). Subsequently, we conducted meta-analyses for each outcome. We report the results of the fixed, as well as the random effects model...
June 20, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27276086/correction-estradiol-enhances-cd4-t-cell-anti-viral-immunity-by-priming-vaginal-dcs-to-induce-th17-responses-via-an-il-1-dependent-pathway
#10
Varun C Anipindi, Puja Bagri, Kristy Roth, Sara E Dizzell, Philip V Nguyen, Christopher R Shaler, Derek K Chu, Rodrigo Jiménez-Saiz, Hong Liang, Stephanie L Swift, Aisha Nazli, Jessica K Kafka, Jonathan Bramson, Zhou Xing, Manel Jordana, Yonghong Wan, Denis P Snider, Martin R Stampfli, Charu Kaushic
[This corrects the article DOI: 10.1371/journal.ppat.1005589.].
June 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27183620/privileged-antigen-presentation-in-splenic-b-cell-follicles-maximizes-t-cell-responses-in-prime-boost-vaccination
#11
Byram W Bridle, Andrew Nguyen, Omar Salem, Liang Zhang, Sandeep Koshy, Derek Clouthier, Lan Chen, Jonathan Pol, Stephanie L Swift, Dawn M E Bowdish, Brian D Lichty, Jonathan L Bramson, Yonghong Wan
Effector T cells (TEFF) are a barrier to booster vaccination because they can rapidly kill Ag-bearing APCs before memory T cells are engaged. We report in this study that i.v. delivery of rhabdoviral vectors leads to direct infection of follicular B cells in the spleen, where the earliest evidence of secondary T cell responses was observed. This allows booster immunizations to rapidly expand CD8(+) central memory T cells (TCM) during the acute phase of the primary response that is dominated by TEFF Interestingly, although the ablation of B cells before boosting with rhabdoviral vectors diminishes the expansion of memory T cells, B cells do not present Ags directly...
June 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27150103/no-space-left-for-intravenous-thrombolysis-in-acute-stroke-pros
#12
Kateryna Antonenko, Valeria Caso
Five recently published RCTs (MR CLEAN, EXTEND-IA, SWIFT PRIME, REVASCAT and ESCAPE) employing mechanical thrombectomy with modern stent retriever devices clearly demonstrated the superiority of endovascular treatment compared to thrombolysis alone, which is now considered standard first-line therapy for selected patients with acute severe ischemic stroke and large vessel in the anterior circulation. RCT results led to recommendations outlined in "Mechanical thrombectomy in acute ischemic stroke by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN"...
August 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27148737/estradiol-enhances-cd4-t-cell-anti-viral-immunity-by-priming-vaginal-dcs-to-induce-th17-responses-via-an-il-1-dependent-pathway
#13
Varun C Anipindi, Puja Bagri, Kristy Roth, Sara E Dizzell, Philip V Nguyen, Christopher R Shaler, Derek K Chu, Rodrigo Jiménez-Saiz, Hong Liang, Stephanie Swift, Aisha Nazli, Jessica K Kafka, Jonathan Bramson, Zhou Xing, Manel Jordana, Yonghong Wan, Denis P Snider, Martin R Stampfli, Charu Kaushic
Clinical and experimental studies have shown that estradiol (E2) confers protection against HIV and other sexually transmitted infections. Here, we investigated the underlying mechanism. Better protection in E2-treated mice, immunized against genital HSV-2, coincided with earlier recruitment and higher proportions of Th1 and Th17 effector cells in the vagina post-challenge, compared to placebo-treated controls. Vaginal APCs isolated from E2-treated mice induced 10-fold higher Th17 and Th1 responses, compared to APCs from progesterone-treated, placebo-treated, and estradiol-receptor knockout mice in APC-T cell co-cultures...
May 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27092472/analysis-of-workflow-and-time-to-treatment-and-the-effects-on-outcome-in-endovascular-treatment-of-acute-ischemic-stroke-results-from-the-swift-prime-randomized-controlled-trial
#14
Mayank Goyal, Ashutosh P Jadhav, Alain Bonafe, Hans Diener, Vitor Mendes Pereira, Elad Levy, Blaise Baxter, Tudor Jovin, Reza Jahan, Bijoy K Menon, Jeffrey L Saver
Purpose To study the relationship between functional independence and time to reperfusion in the Solitaire with the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) trial in patients with disabling acute ischemic stroke who underwent endovascular therapy plus intravenous tissue plasminogen activator (tPA) administration versus tPA administration alone and to investigate variables that affect time spent during discrete steps. Materials and Methods Data were analyzed from the SWIFT PRIME trial, a global, multicenter, prospective study in which outcomes were compared in patients treated with intravenous tPA alone or in combination with the Solitaire device (Covidien, Irvine, Calif)...
June 2016: Radiology
https://www.readbyqxmd.com/read/27046347/cost-effectiveness-of-stent-retriever-thrombectomy-in-combination-with-iv-t-pa-compared-with-iv-t-pa-alone-for-acute-ischemic-stroke-in-the-uk
#15
Kyriakos Lobotesis, Roland Veltkamp, Isobel H Carpenter, Lindsay M Claxton, Jeffrey L Saver, Robert Hodgson
OBJECTIVE: To evaluate the cost-effectiveness of neurothrombectomy with a stent retriever (Solitaire * Revascularization Device) in treating acute ischemic stroke patients from the UK healthcare provider perspective. METHODS: A Markov model was developed to simulate health outcomes and costs of two therapies over a lifetime time horizon: stent-retriever thrombectomy in combination with intravenous tissue-type plasminogen activator (IV t-PA), and IV t-PA alone. The model incorporated an acute phase (0-90 days) and a rest of life phase (90+ days)...
August 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/26898852/endovascular-thrombectomy-after-large-vessel-ischaemic-stroke-a-meta-analysis-of-individual-patient-data-from-five-randomised-trials
#16
Mayank Goyal, Bijoy K Menon, Wim H van Zwam, Diederik W J Dippel, Peter J Mitchell, Andrew M Demchuk, Antoni Dávalos, Charles B L M Majoie, Aad van der Lugt, Maria A de Miquel, Geoffrey A Donnan, Yvo B W E M Roos, Alain Bonafe, Reza Jahan, Hans-Christoph Diener, Lucie A van den Berg, Elad I Levy, Olvert A Berkhemer, Vitor M Pereira, Jeremy Rempel, Mònica Millán, Stephen M Davis, Daniel Roy, John Thornton, Luis San Román, Marc Ribó, Debbie Beumer, Bruce Stouch, Scott Brown, Bruce C V Campbell, Robert J van Oostenbrugge, Jeffrey L Saver, Michael D Hill, Tudor G Jovin
BACKGROUND: In 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. In this meta-analysis we, the trial investigators, aimed to pool individual patient data from these trials to address remaining questions about whether the therapy is efficacious across the diverse populations included. METHODS: We formed the HERMES collaboration to pool patient-level data from five trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA) done between December, 2010, and December, 2014...
April 23, 2016: Lancet
https://www.readbyqxmd.com/read/26888532/safety-and-efficacy-of-solitaire-stent-thrombectomy-individual-patient-data-meta-analysis-of-randomized-trials
#17
Bruce C V Campbell, Michael D Hill, Marta Rubiera, Bijoy K Menon, Andrew Demchuk, Geoffrey A Donnan, Daniel Roy, John Thornton, Laura Dorado, Alain Bonafe, Elad I Levy, Hans-Christoph Diener, María Hernández-Pérez, Vitor Mendes Pereira, Jordi Blasco, Helena Quesada, Jeremy Rempel, Reza Jahan, Stephen M Davis, Bruce C Stouch, Peter J Mitchell, Tudor G Jovin, Jeffrey L Saver, Mayank Goyal
BACKGROUND AND PURPOSE: Recent positive randomized trials of endovascular therapy for ischemic stroke used predominantly stent retrievers. We pooled data to investigate the efficacy and safety of stent thrombectomy using the Solitaire device in anterior circulation ischemic stroke. METHODS: Patient-level data were pooled from trials in which the Solitaire was the only or the predominant device used in a prespecified meta-analysis (SEER Collaboration): Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment (SWIFT PRIME), Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times (ESCAPE), Extending the Time for Thrombolysis in Emergency Neurological Deficits-Intra-Arterial (EXTEND-IA), and Randomized Trial of Revascularization With Solitaire FR Device Versus Best Medical Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting Within Eight Hours of Symptom Onset (REVASCAT)...
March 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/26873954/cost-effectiveness-of-endovascular-thrombectomy-in-patients-with-acute-ischemic-stroke
#18
RANDOMIZED CONTROLLED TRIAL
Mattias Aronsson, Josefine Persson, Christian Blomstrand, Per Wester, Lars-Åke Levin
OBJECTIVE: To evaluate the cost-effectiveness of adding endovascular thrombectomy to standard care in patients with acute ischemic stroke. METHODS: The cost-effectiveness analysis of endovascular thrombectomy in patients with acute ischemic stroke was based on a decision-analytic Markov model. Primary outcomes from ESCAPE, Extending the Time for Thrombolysis in Emergency Neurological Deficits-Intra-Arterial (EXTEND-IA), Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN), Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours (REVASCAT), and Solitaire with the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) along with data from published studies and registries were used in this analysis...
March 15, 2016: Neurology
https://www.readbyqxmd.com/read/26782336/randomized-trials-of-endovascular-therapy-for-stroke-impact-on-stroke-care
#19
REVIEW
Maxim Mokin, Haydy Rojas, Elad I Levy
Five trials that investigated the efficacy of modern endovascular therapies for stroke--MR CLEAN, ESCAPE, SWIFT PRIME, EXTEND IA and REVASCAT--have been published within the past year, changing the landscape of acute stroke management. The trials used a variety of imaging modalities and combinations of treatment approaches, including the mandatory use of intravenous thrombolysis before the initiation of endovascular therapy. All five trials provided strong evidence to support the use of thrombectomy that is initiated within 6 h of stroke onset, prompting worldwide changes in the guidelines for management of acute stroke by endovascular treatment...
February 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/26655871/stent-retriever-thrombectomy-for-acute-ischemic-stroke-indications-results-and-management-in-2015
#20
B Gory, R Riva, P E Labeyrie, F Turjman
The functional benefit of stent retriever thrombectomy in acute ischemic stroke has been clearly demonstrated in recent positive MR CLEAN, ESCAPE, EXTEND-IA, SWIFT PRIME, REVASCAT and THRACE trials. Thrombectomy, in association with intravenous thrombolysis, should now be offered to patients with documented occlusion of the distal internal carotid or proximal middle cerebral arteries, with a relatively normal unenhanced computed tomography (CT), and within 6hours after the onset of symptoms. Thrombectomy results in a mean absolute decrease in handicap of 22% (14 to 31%)...
February 2016: Diagnostic and Interventional Imaging
keyword
keyword
761
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"